RAB1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)9.26813122
2Golgi transport vesicle coating (GO:0048200)9.26813122
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.94699129
4protein retention in ER lumen (GO:0006621)6.43288188
5COPII vesicle coating (GO:0048208)5.98914211
6retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.31487868
7vesicle coating (GO:0006901)5.06402989
8activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.89474567
9positive regulation of nuclease activity (GO:0032075)4.63495015
10endoplasmic reticulum unfolded protein response (GO:0030968)4.22233508
11protein maturation by protein folding (GO:0022417)4.21572929
12exocrine pancreas development (GO:0031017)4.19505473
13regulation of nuclease activity (GO:0032069)4.17002275
14cellular response to unfolded protein (GO:0034620)4.04693727
15ER-nucleus signaling pathway (GO:0006984)3.96768986
16L-serine transport (GO:0015825)3.90321271
17positive regulation of mitochondrial fission (GO:0090141)3.89628341
18cellular response to topologically incorrect protein (GO:0035967)3.86441374
19peptide hormone processing (GO:0016486)3.73397168
20membrane budding (GO:0006900)3.64530095
21response to endoplasmic reticulum stress (GO:0034976)3.55641542
22regulation of type B pancreatic cell apoptotic process (GO:2000674)3.53636069
23cellular response to vitamin D (GO:0071305)3.46404829
24UDP-N-acetylglucosamine metabolic process (GO:0006047)3.45975768
25L-alpha-amino acid transmembrane transport (GO:1902475)3.45152017
26intestinal epithelial cell development (GO:0060576)3.40333461
27pyrimidine nucleobase catabolic process (GO:0006208)3.39966679
28toxin metabolic process (GO:0009404)3.36523421
29ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.36133853
30serine transport (GO:0032329)3.29416448
31regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.29121893
32cullin deneddylation (GO:0010388)3.28503824
33peptidyl-cysteine modification (GO:0018198)3.28469985
34endocrine pancreas development (GO:0031018)3.24797774
35signal peptide processing (GO:0006465)3.22503500
36sequestering of metal ion (GO:0051238)3.19503489
37response to unfolded protein (GO:0006986)3.18763363
38cholesterol biosynthetic process (GO:0006695)3.17943548
39ribonucleoprotein complex disassembly (GO:0032988)3.17387446
40protein N-linked glycosylation via asparagine (GO:0018279)3.14697424
41peptidyl-asparagine modification (GO:0018196)3.13707602
42regulation of early endosome to late endosome transport (GO:2000641)3.13545573
43proteasome assembly (GO:0043248)3.12264426
444-hydroxyproline metabolic process (GO:0019471)3.11611647
45cellular response to vitamin (GO:0071295)3.09625417
46response to topologically incorrect protein (GO:0035966)3.07120911
47nucleobase catabolic process (GO:0046113)3.06239806
48protein deneddylation (GO:0000338)3.00770887
49ER overload response (GO:0006983)3.00670044
50sterol biosynthetic process (GO:0016126)2.99792452
51* ER to Golgi vesicle-mediated transport (GO:0006888)2.98517774
52membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.97079884
53protein localization to cilium (GO:0061512)2.92460908
54nucleotide-sugar biosynthetic process (GO:0009226)2.86723324
55protein N-linked glycosylation (GO:0006487)2.85166694
56ATP hydrolysis coupled proton transport (GO:0015991)2.83534615
57energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.83534615
58macroautophagy (GO:0016236)2.83401191
59peptidyl-proline hydroxylation (GO:0019511)2.79848778
60regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.78236765
61positive regulation of hormone biosynthetic process (GO:0046886)2.72750230
62regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.72656822
63positive regulation of glycolytic process (GO:0045821)2.71282318
64insulin secretion (GO:0030073)2.70923092
65fatty acid elongation (GO:0030497)2.70211916
66intestinal absorption (GO:0050892)2.69360799
67glandular epithelial cell differentiation (GO:0002067)2.67768744
68regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.67683060
69calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.66802220
70platelet dense granule organization (GO:0060155)2.66677845
71keratinocyte development (GO:0003334)2.66411615
72transferrin transport (GO:0033572)2.66365748
73* establishment of melanosome localization (GO:0032401)2.64301225
74apoptotic cell clearance (GO:0043277)2.64172728
75negative regulation of protein localization to plasma membrane (GO:1903077)2.62616910
76protein hydroxylation (GO:0018126)2.61913845
77positive regulation of actin filament depolymerization (GO:0030836)2.61515702
78tricarboxylic acid metabolic process (GO:0072350)2.60154383
79cellular response to nutrient (GO:0031670)2.58015332
80mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.57906401
81positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.57906401
82membrane repolarization during action potential (GO:0086011)2.57766660
83positive regulation of nitric-oxide synthase activity (GO:0051000)2.57105430
84polarized epithelial cell differentiation (GO:0030859)2.56648013
85negative regulation of fatty acid transport (GO:2000192)2.56404402
86lipid particle organization (GO:0034389)2.56222188
87* melanosome transport (GO:0032402)2.55923329
88positive regulation of insulin secretion (GO:0032024)2.55561757
89organelle disassembly (GO:1903008)2.55003967
90* Golgi organization (GO:0007030)2.54630764
91* establishment of pigment granule localization (GO:0051905)2.52868282
92intestinal cholesterol absorption (GO:0030299)2.52208954
93cellular zinc ion homeostasis (GO:0006882)2.50718772
94regulation of cofactor metabolic process (GO:0051193)2.50301902
95regulation of coenzyme metabolic process (GO:0051196)2.50301902
96regulation of cholesterol homeostasis (GO:2000188)2.50220876
97negative regulation of synaptic transmission, GABAergic (GO:0032229)2.50177923
98columnar/cuboidal epithelial cell development (GO:0002066)2.47360650
99type B pancreatic cell proliferation (GO:0044342)2.47143926
100ganglion development (GO:0061548)2.46310052
101endoplasmic reticulum organization (GO:0007029)2.46039697
102cell adhesion mediated by integrin (GO:0033627)2.45815592
103nitric oxide mediated signal transduction (GO:0007263)2.44974457
104* pigment granule transport (GO:0051904)2.44344907
105zinc ion transport (GO:0006829)2.43725056
106ferric iron transport (GO:0015682)2.43118050
107trivalent inorganic cation transport (GO:0072512)2.43118050
108cellular response to glucose starvation (GO:0042149)2.42863582
109glycosphingolipid biosynthetic process (GO:0006688)2.42382179
110* Golgi vesicle transport (GO:0048193)2.41773474
111isoprenoid biosynthetic process (GO:0008299)2.40217818
112hormone catabolic process (GO:0042447)2.39773209
113nitric oxide biosynthetic process (GO:0006809)2.39438040
114hippo signaling (GO:0035329)2.37218796
115peptide catabolic process (GO:0043171)2.37058405
116regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.36635422
117regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.36090424
118magnesium ion transport (GO:0015693)2.35753001
119positive regulation of glycogen biosynthetic process (GO:0045725)2.35503116
120desmosome organization (GO:0002934)2.35426750
121regulation of clathrin-mediated endocytosis (GO:2000369)2.34151952
122regulation of insulin secretion (GO:0050796)2.34141207
123positive regulation of vesicle fusion (GO:0031340)2.33458602
124* localization within membrane (GO:0051668)2.33195769
125cerebellar Purkinje cell layer development (GO:0021680)2.32107414
126de novo protein folding (GO:0006458)2.31848521
127* melanosome localization (GO:0032400)2.31400040
128de novo posttranslational protein folding (GO:0051084)2.31381619
129type B pancreatic cell development (GO:0003323)2.31270234
130positive regulation of p38MAPK cascade (GO:1900745)2.29573012
131keratan sulfate catabolic process (GO:0042340)2.29569355
132regulation of integrin-mediated signaling pathway (GO:2001044)2.29508175
133ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.29164508
134fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.27951108
135regulation of metalloenzyme activity (GO:0048552)2.26477382
136peroxisome fission (GO:0016559)2.26430383
137intra-Golgi vesicle-mediated transport (GO:0006891)2.26250607
138vesicle organization (GO:0016050)2.25555468
139glutamate secretion (GO:0014047)2.24529148
140phenol-containing compound catabolic process (GO:0019336)2.24341390
141positive regulation of protein targeting to membrane (GO:0090314)2.23853674
142decidualization (GO:0046697)2.23789819
143short-term memory (GO:0007614)2.23593653
144regulation of sulfur metabolic process (GO:0042762)2.23434683
145regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.22919668
146synaptic vesicle maturation (GO:0016188)2.22732127
147* pigment granule localization (GO:0051875)2.22290725
148L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.20569112
149chondrocyte development (GO:0002063)2.19545176
150glandular epithelial cell development (GO:0002068)2.18885143
151anterograde synaptic vesicle transport (GO:0048490)2.18600112
152regulation of cell fate specification (GO:0042659)2.17635727
153* peptide secretion (GO:0002790)2.16961561
154muscle organ morphogenesis (GO:0048644)2.16872754
155cellular response to leptin stimulus (GO:0044320)2.16732627
156regulation of acyl-CoA biosynthetic process (GO:0050812)2.16262788
157regulation of SMAD protein import into nucleus (GO:0060390)2.16237731
158intraciliary transport (GO:0042073)2.15669576
159cellular copper ion homeostasis (GO:0006878)2.14901936
160response to dietary excess (GO:0002021)2.14510617
161regulation of mitochondrial fission (GO:0090140)2.14428465
162protein neddylation (GO:0045116)2.12846906
163neurofilament cytoskeleton organization (GO:0060052)2.10563152
164gamma-aminobutyric acid transport (GO:0015812)2.10189326
165regulation of cellular amino acid metabolic process (GO:0006521)2.09512057
166negative regulation of receptor-mediated endocytosis (GO:0048261)2.09354427
167regulation of cilium movement (GO:0003352)2.09338810
168vocalization behavior (GO:0071625)2.05674971
169negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.05286083
170positive regulation of protein depolymerization (GO:1901881)2.05123598
171* establishment of vesicle localization (GO:0051650)2.04016111
172synapse assembly (GO:0007416)2.03542803
173synaptic vesicle exocytosis (GO:0016079)2.02682828
174* vesicle localization (GO:0051648)2.01059988
175regulation of Golgi to plasma membrane protein transport (GO:0042996)2.00170196
176regulation of hexokinase activity (GO:1903299)1.98693247
177regulation of glucokinase activity (GO:0033131)1.98693247
178positive regulation of protein complex disassembly (GO:0043243)1.98631125
179protein K48-linked ubiquitination (GO:0070936)1.98034447
180positive regulation of TOR signaling (GO:0032008)1.97567008
181tricarboxylic acid cycle (GO:0006099)1.97517995

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.97429072
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.39021702
3CLOCK_20551151_ChIP-Seq_293T_Human4.08217003
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.46705484
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.11819116
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.95409665
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.73529326
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.72862781
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.56521270
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.56023067
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.51337489
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.43525199
13ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.40775746
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35609286
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.31877273
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.29206219
17SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.28985093
18SOX2_20726797_ChIP-Seq_SW620_Human2.20486261
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14591825
20WT1_19549856_ChIP-ChIP_CCG9911_Human2.12964680
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.10356097
22RXR_22158963_ChIP-Seq_LIVER_Mouse2.09539317
23SALL4_18804426_ChIP-ChIP_XEN_Mouse2.09465640
24TAF15_26573619_Chip-Seq_HEK293_Human2.08664748
25SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.08335671
26IGF1R_20145208_ChIP-Seq_DFB_Human2.07616310
27SOX2_27498859_Chip-Seq_STOMACH_Mouse2.06269364
28GBX2_23144817_ChIP-Seq_PC3_Human2.05698381
29ESR2_21235772_ChIP-Seq_MCF-7_Human2.05448562
30ZNF263_19887448_ChIP-Seq_K562_Human1.98132815
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.94219194
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.92913662
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91343626
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.85818190
35PPARA_22158963_ChIP-Seq_LIVER_Mouse1.79716472
36* P300_19829295_ChIP-Seq_ESCs_Human1.78381834
37FUS_26573619_Chip-Seq_HEK293_Human1.77853876
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.77781200
39* ELK1_19687146_ChIP-ChIP_HELA_Human1.77296016
40LXR_22158963_ChIP-Seq_LIVER_Mouse1.75824400
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74637099
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.70448588
43NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.70207806
44NRF2_20460467_ChIP-Seq_MEFs_Mouse1.70207806
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66310750
46ATF3_27146783_Chip-Seq_COLON_Human1.66018717
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.65691889
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63952594
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63297195
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.62337422
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60790658
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.60693475
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60665995
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.60394058
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57454840
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.56264150
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51952597
58ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.51858333
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51600429
60FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.51544277
61EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.50250880
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.49736329
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48856172
64TP53_18474530_ChIP-ChIP_U2OS_Human1.48682453
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.48196699
66CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47877657
67CJUN_26792858_Chip-Seq_BT549_Human1.45957515
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43663296
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42600054
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.38979552
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37827749
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37683090
73SMAD4_21799915_ChIP-Seq_A2780_Human1.37539290
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37448716
75HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34496593
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34413489
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34413489
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.34145790
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.33946949
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33235215
81TCF3_18692474_ChIP-Seq_MEFs_Mouse1.31422595
82CHD1_26751641_Chip-Seq_LNCaP_Human1.31104119
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30254071
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29708556
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29650545
86EWS_26573619_Chip-Seq_HEK293_Human1.29547091
87GATA6_25053715_ChIP-Seq_YYC3_Human1.28879810
88GATA4_25053715_ChIP-Seq_YYC3_Human1.28569146
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28566913
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27714661
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.26507232
92ZNF274_21170338_ChIP-Seq_K562_Hela1.26499163
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26012607
94GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.25820178
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25546600
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.25390974
97P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24802388
98PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24658142
99* BRD4_25478319_ChIP-Seq_HGPS_Human1.24411856
100GATA3_24758297_ChIP-Seq_MCF-7_Human1.23763459
101FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23430680
102EZH2_27294783_Chip-Seq_NPCs_Mouse1.22658423
103PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20535733
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19920286
105AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.19730150
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17640763
107CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16623315
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16293584
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16223166
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15505842
111GATA1_22025678_ChIP-Seq_K562_Human1.15462089
112REST_19997604_ChIP-ChIP_NEURONS_Mouse1.15282999
113FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15234937
114TFEB_21752829_ChIP-Seq_HELA_Human1.15005985
115ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14889174
116CBP_20019798_ChIP-Seq_JUKART_Human1.14817188
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14817188
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14762945
119FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.14580621
120KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14522817
121NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13732521
122AR_25329375_ChIP-Seq_VCAP_Human1.12508221
123CMYC_18555785_Chip-Seq_ESCs_Mouse1.12193719
124RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11320361
125P53_22387025_ChIP-Seq_ESCs_Mouse1.10584034
126TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10014557
127TAL1_26923725_Chip-Seq_HPCs_Mouse1.09290593
128SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08763228
129RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08682650
130FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08530124
131PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08266883
132ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.07762305
133CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06424104
134EOMES_21245162_ChIP-Seq_HESCs_Human1.05826248
135RXR_22108803_ChIP-Seq_LS180_Human1.05575447
136ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04673964
137UBF1/2_26484160_Chip-Seq_HMECs_Human1.04485339
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04237182
139PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04208712
140VDR_22108803_ChIP-Seq_LS180_Human1.04185554
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04081453
142* JUN_21703547_ChIP-Seq_K562_Human1.03433600
143RACK7_27058665_Chip-Seq_MCF-7_Human1.02656957
144Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02644530
145E2F1_18555785_Chip-Seq_ESCs_Mouse1.02556116
146PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02283007
147NFE2_27457419_Chip-Seq_LIVER_Mouse1.01733132
148CDX2_20551321_ChIP-Seq_CACO-2_Human1.01010865
149JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99813288
150DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99667286
151ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99105985
152PIAS1_25552417_ChIP-Seq_VCAP_Human0.98996159
153SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.98930764
154DCP1A_22483619_ChIP-Seq_HELA_Human0.98895852
155STAT3_18555785_Chip-Seq_ESCs_Mouse0.97948610
156SOX2_18555785_Chip-Seq_ESCs_Mouse0.97535568
157* CDX2_22108803_ChIP-Seq_LS180_Human0.96764618
158CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96352113
159ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95893752
160TCF4_18268006_ChIP-ChIP_LS174T_Human0.95497109
161P300_18555785_Chip-Seq_ESCs_Mouse0.95324237
162MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94553326
163* TCF4_22108803_ChIP-Seq_LS180_Human0.94306833
164CRX_20693478_ChIP-Seq_RETINA_Mouse0.93920257
165* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93753910
166RUNX2_22187159_ChIP-Seq_PCA_Human0.93514408
167CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93079506
168TP63_23658742_ChIP-Seq_EP156T_Human0.92759234
169FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91692755
170PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91393456
171CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.91331291
172CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91229458
173ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90163516
174BCAT_22108803_ChIP-Seq_LS180_Human0.89366510
175PKCTHETA_26484144_Chip-Seq_BREAST_Human0.88893119
176RUNX1_27514584_Chip-Seq_MCF-7_Human0.88509219

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.05189419
2MP0002877_abnormal_melanocyte_morpholog3.44058411
3MP0003705_abnormal_hypodermis_morpholog3.17265851
4MP0009780_abnormal_chondrocyte_physiolo3.04738447
5MP0003283_abnormal_digestive_organ2.85064088
6MP0000013_abnormal_adipose_tissue2.84132350
7MP0002909_abnormal_adrenal_gland2.79100061
8MP0003195_calcinosis2.72948962
9MP0004270_analgesia2.62839736
10MP0006054_spinal_hemorrhage2.46240701
11MP0001529_abnormal_vocalization2.33491303
12MP0004043_abnormal_pH_regulation2.32909724
13MP0001984_abnormal_olfaction2.25062211
14MP0004264_abnormal_extraembryonic_tissu2.22117841
15MP0002896_abnormal_bone_mineralization2.21857841
16MP0008438_abnormal_cutaneous_collagen2.18842703
17MP0005220_abnormal_exocrine_pancreas2.18100208
18MP0005394_taste/olfaction_phenotype2.17503229
19MP0005499_abnormal_olfactory_system2.17503229
20MP0010352_gastrointestinal_tract_polyps2.14597902
21MP0003941_abnormal_skin_development2.12883237
22MP0003221_abnormal_cardiomyocyte_apopto2.03754836
23MP0010386_abnormal_urinary_bladder2.03157598
24MP0001944_abnormal_pancreas_morphology2.01531561
25MP0005275_abnormal_skin_tensile2.00397259
26MP0002102_abnormal_ear_morphology1.96496991
27MP0008789_abnormal_olfactory_epithelium1.96163451
28MP0003183_abnormal_peptide_metabolism1.94289910
29MP0003300_gastrointestinal_ulcer1.92128346
30MP0004272_abnormal_basement_membrane1.92085213
31MP0002693_abnormal_pancreas_physiology1.91524180
32MP0003566_abnormal_cell_adhesion1.87352364
33MP0003880_abnormal_central_pattern1.87008231
34MP0000647_abnormal_sebaceous_gland1.69684608
35MP0005076_abnormal_cell_differentiation1.69548410
36MP0002139_abnormal_hepatobiliary_system1.65374176
37MP0009046_muscle_twitch1.62259887
38MP0005084_abnormal_gallbladder_morpholo1.60146425
39MP0005058_abnormal_lysosome_morphology1.56626595
40MP0002822_catalepsy1.54439446
41MP0003121_genomic_imprinting1.48661409
42MP0003252_abnormal_bile_duct1.46735857
43MP0000516_abnormal_urinary_system1.46582963
44MP0005367_renal/urinary_system_phenotyp1.46582963
45MP0000003_abnormal_adipose_tissue1.45795296
46MP0003186_abnormal_redox_activity1.44226011
47MP0001188_hyperpigmentation1.42225208
48MP0005248_abnormal_Harderian_gland1.42220652
49MP0000372_irregular_coat_pigmentation1.41764681
50MP0003122_maternal_imprinting1.41717111
51MP0004859_abnormal_synaptic_plasticity1.40842047
52MP0001666_abnormal_nutrient_absorption1.38529023
53MP0005503_abnormal_tendon_morphology1.37660112
54MP0001756_abnormal_urination1.37188185
55MP0009643_abnormal_urine_homeostasis1.34574361
56MP0001299_abnormal_eye_distance/1.31926577
57MP0005187_abnormal_penis_morphology1.31586009
58MP0002078_abnormal_glucose_homeostasis1.30784871
59MP0005365_abnormal_bile_salt1.29440522
60MP0009384_cardiac_valve_regurgitation1.28327454
61MP0004782_abnormal_surfactant_physiolog1.27424110
62MP0006276_abnormal_autonomic_nervous1.24824790
63MP0002233_abnormal_nose_morphology1.23980082
64MP0004233_abnormal_muscle_weight1.20766620
65MP0005257_abnormal_intraocular_pressure1.17821503
66MP0009053_abnormal_anal_canal1.17406353
67MP0000537_abnormal_urethra_morphology1.15334155
68MP0005083_abnormal_biliary_tract1.14315563
69MP0002138_abnormal_hepatobiliary_system1.12542223
70MP0001727_abnormal_embryo_implantation1.10106824
71MP0003385_abnormal_body_wall1.09164727
72MP0005085_abnormal_gallbladder_physiolo1.09078723
73MP0002734_abnormal_mechanical_nocicepti1.06932899
74MP0004215_abnormal_myocardial_fiber1.04306358
75MP0005360_urolithiasis1.02857607
76MP0008961_abnormal_basal_metabolism1.02539351
77MP0004133_heterotaxia1.02434853
78MP0000538_abnormal_urinary_bladder1.02157735
79MP0000778_abnormal_nervous_system1.02012069
80MP0000462_abnormal_digestive_system1.01341063
81MP0003119_abnormal_digestive_system0.98115320
82MP0009840_abnormal_foam_cell0.98081919
83MP0004858_abnormal_nervous_system0.96864563
84MP0003011_delayed_dark_adaptation0.96225771
85MP0005332_abnormal_amino_acid0.95450217
86MP0003868_abnormal_feces_composition0.95009945
87MP0003191_abnormal_cellular_cholesterol0.94822620
88MP0002837_dystrophic_cardiac_calcinosis0.94732450
89MP0002751_abnormal_autonomic_nervous0.94434389
90MP0003567_abnormal_fetal_cardiomyocyte0.93418527
91MP0001765_abnormal_ion_homeostasis0.93272802
92MP0005408_hypopigmentation0.92208060
93MP0010678_abnormal_skin_adnexa0.91996526
94MP0001881_abnormal_mammary_gland0.90606940
95MP0001849_ear_inflammation0.90590535
96MP0005253_abnormal_eye_physiology0.90459862
97MP0003890_abnormal_embryonic-extraembry0.89595492
98MP0003123_paternal_imprinting0.89086396
99MP0005379_endocrine/exocrine_gland_phen0.88487186
100MP0003755_abnormal_palate_morphology0.88124468
101MP0004130_abnormal_muscle_cell0.87862892
102MP0000613_abnormal_salivary_gland0.87548434
103MP0002796_impaired_skin_barrier0.87225414
104MP0004484_altered_response_of0.87101947
105MP0003172_abnormal_lysosome_physiology0.86758512
106MP0004185_abnormal_adipocyte_glucose0.86459000
107MP0002295_abnormal_pulmonary_circulatio0.86214071
108MP0000427_abnormal_hair_cycle0.85952497
109MP0005501_abnormal_skin_physiology0.85053779
110MP0000163_abnormal_cartilage_morphology0.85005189
111MP0005386_behavior/neurological_phenoty0.84842873
112MP0004924_abnormal_behavior0.84842873
113MP0004019_abnormal_vitamin_homeostasis0.84741579
114MP0003091_abnormal_cell_migration0.84430193
115MP0000639_abnormal_adrenal_gland0.84348060
116MP0003950_abnormal_plasma_membrane0.83898527
117MP0003787_abnormal_imprinting0.82932558
118MP0004811_abnormal_neuron_physiology0.81914247
119MP0005375_adipose_tissue_phenotype0.81732701
120MP0005023_abnormal_wound_healing0.81103732
121MP0008004_abnormal_stomach_pH0.80165382
122MP0000678_abnormal_parathyroid_gland0.79851538
123MP0000604_amyloidosis0.79575065
124MP0003953_abnormal_hormone_level0.79563142
125MP0000358_abnormal_cell_content/0.78923548
126MP0002332_abnormal_exercise_endurance0.78021345
127MP0002928_abnormal_bile_duct0.77198387
128MP0003959_abnormal_lean_body0.77062044
129MP0005645_abnormal_hypothalamus_physiol0.77021120
130MP0002557_abnormal_social/conspecific_i0.76679032
131MP0002736_abnormal_nociception_after0.75874544
132MP0005423_abnormal_somatic_nervous0.75678833
133MP0004147_increased_porphyrin_level0.75649756
134MP0003718_maternal_effect0.75640547
135MP0008260_abnormal_autophagy0.75100063
136MP0003795_abnormal_bone_structure0.74966836
137MP0003279_aneurysm0.74719159
138MP0002090_abnormal_vision0.74511300
139MP0000049_abnormal_middle_ear0.73928482
140MP0002572_abnormal_emotion/affect_behav0.72763304
141MP0002115_abnormal_skeleton_extremities0.71860487
142MP0005623_abnormal_meninges_morphology0.71098501
143MP0001986_abnormal_taste_sensitivity0.70846953
144MP0005508_abnormal_skeleton_morphology0.70379906
145MP0001177_atelectasis0.70172958
146MP0002272_abnormal_nervous_system0.70114302
147MP0002177_abnormal_outer_ear0.69963959
148MP0001324_abnormal_eye_pigmentation0.69797139
149MP0002184_abnormal_innervation0.69767424
150MP0001542_abnormal_bone_strength0.69629229
151MP0000534_abnormal_ureter_morphology0.69167956
152MP0010329_abnormal_lipoprotein_level0.69003114
153MP0001958_emphysema0.67724718
154MP0008995_early_reproductive_senescence0.66666050
155MP0002069_abnormal_eating/drinking_beha0.66305086
156MP0005448_abnormal_energy_balance0.66072098
157MP0002060_abnormal_skin_morphology0.65949433
158MP0002254_reproductive_system_inflammat0.65528192
159MP0000230_abnormal_systemic_arterial0.65476685
160MP0002098_abnormal_vibrissa_morphology0.65026452
161MP0010368_abnormal_lymphatic_system0.64991650
162MP0008875_abnormal_xenobiotic_pharmacok0.64928841
163MP0002168_other_aberrant_phenotype0.64826207
164MP0005167_abnormal_blood-brain_barrier0.62788337
165MP0003806_abnormal_nucleotide_metabolis0.62615951

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.52794083
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.46072780
3Hypoglycemic seizures (HP:0002173)4.45034544
4Hyperinsulinemic hypoglycemia (HP:0000825)4.40674598
5Symptomatic seizures (HP:0011145)3.82371417
6Cortical dysplasia (HP:0002539)3.56413273
7Hyperglycemia (HP:0003074)3.42434601
8Increased serum pyruvate (HP:0003542)3.38803178
9Urinary glycosaminoglycan excretion (HP:0003541)3.27797066
10Mucopolysacchariduria (HP:0008155)3.27797066
11Abnormality of glycolysis (HP:0004366)3.21293349
12Dysostosis multiplex (HP:0000943)3.20920470
13Ketoacidosis (HP:0001993)3.15310364
14Polyphagia (HP:0002591)3.05528350
15Abnormality of mucopolysaccharide metabolism (HP:0011020)2.94105434
16Abnormality of polysaccharide metabolism (HP:0011012)2.94105434
17Abnormality of glycosaminoglycan metabolism (HP:0004371)2.94105434
18Protrusio acetabuli (HP:0003179)2.93681823
19Tetraparesis (HP:0002273)2.88362200
20Gout (HP:0001997)2.85779938
21Agitation (HP:0000713)2.83244706
22Insulin-resistant diabetes mellitus (HP:0000831)2.72856760
23Gait imbalance (HP:0002141)2.70022714
24Abnormality of calcium-phosphate metabolism (HP:0100530)2.69690215
25Abnormal pancreas size (HP:0012094)2.68752478
26Hand muscle atrophy (HP:0009130)2.66789489
27Hydroxyprolinuria (HP:0003080)2.60988921
28Abnormality of proline metabolism (HP:0010907)2.60988921
29Congenital primary aphakia (HP:0007707)2.59573169
30Nephrogenic diabetes insipidus (HP:0009806)2.58778829
31Late onset (HP:0003584)2.56730774
32Mutism (HP:0002300)2.56238698
33Cervical subluxation (HP:0003308)2.51542243
34Papillary thyroid carcinoma (HP:0002895)2.48248436
35Insidious onset (HP:0003587)2.45965711
36Termporal pattern (HP:0011008)2.45965711
37Hyperparathyroidism (HP:0000843)2.40473473
38Autoamputation (HP:0001218)2.39400553
39Intrahepatic cholestasis (HP:0001406)2.38836522
40Limb dystonia (HP:0002451)2.36339344
41Medial flaring of the eyebrow (HP:0010747)2.34800606
42Increased cerebral lipofuscin (HP:0011813)2.30424472
43Abnormality of the musculature of the pelvis (HP:0001469)2.29442243
44Abnormality of the hip-girdle musculature (HP:0001445)2.29442243
45Thoracolumbar scoliosis (HP:0002944)2.28555570
46Poor suck (HP:0002033)2.27708449
47Right ventricular cardiomyopathy (HP:0011663)2.26774804
48Protuberant abdomen (HP:0001538)2.26121931
49Atrophy/Degeneration involving motor neurons (HP:0007373)2.24935810
50Abnormality of the intrinsic pathway (HP:0010989)2.24525627
51Delayed gross motor development (HP:0002194)2.23120634
52Abdominal distention (HP:0003270)2.22523734
53Upper limb muscle weakness (HP:0003484)2.20607317
54Hypercortisolism (HP:0001578)2.19866788
55Adrenal hypoplasia (HP:0000835)2.18656929
56Genital tract atresia (HP:0001827)2.17660416
57Sensorimotor neuropathy (HP:0007141)2.16101737
58Hepatoblastoma (HP:0002884)2.15954237
59Premature rupture of membranes (HP:0001788)2.14039702
60Vaginal atresia (HP:0000148)2.13912161
61Cerebral aneurysm (HP:0004944)2.13294655
62Drooling (HP:0002307)2.11648603
63Thyroid carcinoma (HP:0002890)2.11290554
64Back pain (HP:0003418)2.10555731
65Abnormality of the pancreatic islet cells (HP:0006476)2.09951636
66Abnormality of endocrine pancreas physiology (HP:0012093)2.09951636
67Hypokalemia (HP:0002900)2.09413901
68Epidermoid cyst (HP:0200040)2.08846959
69Atrophic scars (HP:0001075)2.04580625
70Generalized aminoaciduria (HP:0002909)2.02120094
71Abnormality of glutamine family amino acid metabolism (HP:0010902)2.02072410
72Increased neuronal autofluorescent lipopigment (HP:0002074)2.00425100
73Aortic aneurysm (HP:0004942)1.99858846
74Restlessness (HP:0000711)1.99654720
75Thin bony cortex (HP:0002753)1.98670955
76Abnormality of purine metabolism (HP:0004352)1.98481620
77Pheochromocytoma (HP:0002666)1.98388782
78Abnormality of the distal phalanges of the toes (HP:0010182)1.97819746
79Retinal atrophy (HP:0001105)1.97640303
80Papilledema (HP:0001085)1.97506349
81Shoulder girdle muscle weakness (HP:0003547)1.96386838
82Vacuolated lymphocytes (HP:0001922)1.95916822
83Spastic tetraplegia (HP:0002510)1.94519228
84Labial hypoplasia (HP:0000066)1.93624134
85Broad alveolar ridges (HP:0000187)1.93561126
86Muscular hypotonia of the trunk (HP:0008936)1.93311237
87Hyperactive renin-angiotensin system (HP:0000841)1.92085912
88Proximal tubulopathy (HP:0000114)1.92079941
89Failure to thrive in infancy (HP:0001531)1.91497930
90Decreased muscle mass (HP:0003199)1.90656862
91Upper limb amyotrophy (HP:0009129)1.90367150
92Distal upper limb amyotrophy (HP:0007149)1.90367150
93Amyotrophic lateral sclerosis (HP:0007354)1.89880379
94Vertebral compression fractures (HP:0002953)1.89521647
95Beaking of vertebral bodies (HP:0004568)1.89467734
96Skin nodule (HP:0200036)1.88788275
97Aneurysm (HP:0002617)1.88592025
98Follicular hyperkeratosis (HP:0007502)1.87938874
99Abnormality of alanine metabolism (HP:0010916)1.87751357
100Hyperalaninemia (HP:0003348)1.87751357
101Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87751357
102Striae distensae (HP:0001065)1.87378336
103Epiphyseal dysplasia (HP:0002656)1.87075169
104Neoplasm of the adrenal gland (HP:0100631)1.86403344
105Insulin resistance (HP:0000855)1.86123840
106Patchy hypopigmentation of hair (HP:0011365)1.85397495
107Hypsarrhythmia (HP:0002521)1.84791479
108Intestinal atresia (HP:0011100)1.84442219
109Decreased activity of mitochondrial respiratory chain (HP:0008972)1.82839662
110Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.82839662
111Ketosis (HP:0001946)1.81708725
112Hypothermia (HP:0002045)1.81655537
113Vascular tortuosity (HP:0004948)1.80682004
114EEG with generalized epileptiform discharges (HP:0011198)1.80478145
115Absent eyebrow (HP:0002223)1.80147499
116Acute necrotizing encephalopathy (HP:0006965)1.79655909
117Excessive salivation (HP:0003781)1.79066693
118Macroorchidism (HP:0000053)1.78339290
119Overgrowth (HP:0001548)1.78236204
120Abnormality of aromatic amino acid family metabolism (HP:0004338)1.77736186
121Osteopenia (HP:0000938)1.77225917
122Split foot (HP:0001839)1.77110600
123Cupped ribs (HP:0000887)1.76855349
124Abnormality of the common coagulation pathway (HP:0010990)1.76717723
125Exostoses (HP:0100777)1.76349804
126Exocrine pancreatic insufficiency (HP:0001738)1.76002911
127Methylmalonic acidemia (HP:0002912)1.75805967
128Congenital glaucoma (HP:0001087)1.75221072
129Urinary urgency (HP:0000012)1.75149050
130Acute encephalopathy (HP:0006846)1.74321401
131Long toe (HP:0010511)1.73393017
132Dilatation of the ascending aorta (HP:0005111)1.73194304
133Arterial tortuosity (HP:0005116)1.73107721
134Pancreatic islet-cell hyperplasia (HP:0004510)1.72845304
135Enlarged penis (HP:0000040)1.72065870
136Postnatal microcephaly (HP:0005484)1.71240783
137Hypotension (HP:0002615)1.71134028
138Vertebral hypoplasia (HP:0008417)1.70557110
139Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.70557110
140Disinhibition (HP:0000734)1.69984328
141Xanthomatosis (HP:0000991)1.69071900
142Metaphyseal cupping (HP:0003021)1.68671696
143Short tibia (HP:0005736)1.68222692
144Hypoplastic female external genitalia (HP:0012815)1.68119457
145Severe short stature (HP:0003510)1.67954877
146Epileptiform EEG discharges (HP:0011182)1.67856688
147Hyperglycinemia (HP:0002154)1.66999098
148Spinal cord compression (HP:0002176)1.66695043
149Decreased circulating renin level (HP:0003351)1.65697727
150Abnormality of glycolipid metabolism (HP:0010969)1.65565015
151Abnormality of liposaccharide metabolism (HP:0010968)1.65565015
152Abnormality of glycosphingolipid metabolism (HP:0004343)1.65565015
153Degeneration of anterior horn cells (HP:0002398)1.65252719
154Abnormality of the anterior horn cell (HP:0006802)1.65252719
155Platyspondyly (HP:0000926)1.64269868
156Hypophosphatemia (HP:0002148)1.64111304
157Bifid tongue (HP:0010297)1.64012870
158Abnormal mitochondria in muscle tissue (HP:0008316)1.63905365
159Specific learning disability (HP:0001328)1.63798113
160Ulnar claw (HP:0001178)1.63356151
161Growth hormone excess (HP:0000845)1.63010288
162Progressive macrocephaly (HP:0004481)1.61462194
163Hypoplasia of the odontoid process (HP:0003311)1.60948873
164Abnormality of chloride homeostasis (HP:0011422)1.60639745
165Broad foot (HP:0001769)1.60232508
166Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.60144208
167Limb-girdle muscle atrophy (HP:0003797)1.59772788
168Decreased testicular size (HP:0008734)1.59288450
169Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.59216670
170Abnormal protein N-linked glycosylation (HP:0012347)1.59216670
171Abnormal protein glycosylation (HP:0012346)1.59216670
172Abnormal glycosylation (HP:0012345)1.59216670
173Hyperextensible skin (HP:0000974)1.59043484
174Flat acetabular roof (HP:0003180)1.58691654
175Adrenal overactivity (HP:0002717)1.58592052
176Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.58025145
177Ovoid vertebral bodies (HP:0003300)1.57596758
178Lymphangioma (HP:0100764)1.56802406
179Spastic diplegia (HP:0001264)1.55926190
180Action tremor (HP:0002345)1.55020724
181Hydroureter (HP:0000072)1.54570047
182Abnormality of the labia (HP:0000058)1.54447568
183Abnormality of the corticospinal tract (HP:0002492)1.53602708
184Apathy (HP:0000741)1.52481514
185Curly hair (HP:0002212)1.52479089
186Double outlet right ventricle (HP:0001719)1.50794014
187Congenital malformation of the right heart (HP:0011723)1.50794014

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.27727409
2ERN13.68172636
3FRK3.51180545
4SCYL23.14161238
5MAP3K22.95788629
6INSRR2.77630185
7CASK2.70010830
8TRIB32.52793943
9MAP3K42.36224291
10MAP2K72.31774369
11MAP4K22.31285016
12NTRK12.21907283
13SIK32.21902670
14FER2.15034693
15PTK22.10189442
16MAPK152.09482867
17LATS12.04029855
18TESK12.03445923
19PASK2.00364190
20CSNK1G22.00249675
21CSNK1G31.99873759
22EPHA21.98250521
23CSNK1A1L1.91068178
24PDGFRA1.87753032
25FLT31.80311796
26WNK31.79345623
27SRPK11.78912964
28MET1.77561780
29RIPK11.74286627
30NEK11.70864305
31PKN21.69737836
32CSNK1G11.69700547
33KSR21.68444149
34MAP3K91.68003213
35ERBB31.67525755
36PAK31.59884983
37LATS21.57857005
38PIM21.55579399
39PTK61.54990849
40DDR21.52858472
41WNK41.52786381
42AKT31.47145765
43LIMK11.46949340
44PRKD31.44303224
45PBK1.42607929
46CAMKK21.39662463
47EPHA31.37935818
48MAP3K31.32687084
49MAP3K11.19474723
50MAPKAPK31.18695163
51NEK91.16691291
52MAP2K11.14692401
53RET1.14685374
54MAP3K61.13362955
55MINK11.09412346
56BCKDK1.07001936
57MST1R1.05941002
58MYLK1.01430565
59BRSK21.00093480
60DYRK1B0.99487995
61EIF2AK10.97959485
62DYRK30.97005532
63SIK10.96551783
64STK240.95021280
65HIPK20.94191767
66KSR10.93223186
67TNIK0.93073834
68PRKCG0.92666912
69PRKG20.91238293
70GRK70.89725705
71ACVR1B0.89090384
72BMPR1B0.87679324
73PAK40.87506616
74EPHB20.86999033
75DYRK20.86247282
76MAPK130.84099721
77PDK20.83130672
78PIK3CG0.81540320
79ARAF0.81221901
80MAP2K20.80920554
81PINK10.80717186
82MAP3K50.79461512
83RPS6KA40.78465496
84STK38L0.75538868
85PLK20.73114457
86FGFR10.71682549
87LMTK20.71281303
88TIE10.70866971
89CDK180.70420248
90CDK60.69259765
91MARK10.66124945
92CAMK2A0.63991432
93GSK3A0.62511080
94TSSK60.62302480
95ERBB40.61298660
96CAMKK10.60450129
97CAMK2D0.59661423
98MKNK10.59114728
99MKNK20.56466930
100BCR0.56423474
101CAMK2B0.55163105
102PIK3CA0.54671032
103EPHA40.54338904
104GRK10.54049442
105MTOR0.53544865
106IRAK10.52967779
107MAP2K40.52720061
108TAOK30.52588427
109TGFBR20.52313521
110CDK150.51659859
111PAK20.50150731
112STK390.50135014
113FGFR30.49935739
114CDK140.49726676
115CAMK2G0.49201377
116LRRK20.48918577
117PAK60.48130366
118BUB10.47677989
119OXSR10.47504137
120PDGFRB0.46371709
121NTRK30.46178182
122CDK190.46047530
123CDK50.46007917
124TAOK10.46002838
125ADRBK20.45493070
126PRKCE0.45160655
127CDK11A0.44698148
128STK30.43956543
129ALK0.43394165
130MST40.41395287
131TGFBR10.41248338
132DMPK0.41222875
133DYRK1A0.40476230
134EGFR0.40421609
135STK160.39689954
136PRKCI0.38818144
137CSNK1A10.38601324
138EIF2AK30.38556836
139IGF1R0.34021788
140FGFR40.33426667
141PDPK10.31969403
142ERBB20.31887364
143SGK30.30943183
144PLK30.30142555
145JAK20.29382853
146PRKCH0.28494104
147UHMK10.28424566
148PRKACG0.27625730
149ABL20.25450043
150MAP3K120.25123934

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.85565445
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.87113931
3Nitrogen metabolism_Homo sapiens_hsa009102.85721993
4Steroid biosynthesis_Homo sapiens_hsa001002.74412817
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.59488543
6Protein export_Homo sapiens_hsa030602.55361213
7Sulfur metabolism_Homo sapiens_hsa009202.54910292
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.50731986
9Vibrio cholerae infection_Homo sapiens_hsa051102.34164443
10Fatty acid elongation_Homo sapiens_hsa000622.17061658
11Proteasome_Homo sapiens_hsa030502.14316862
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89898343
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.88186622
14Lysosome_Homo sapiens_hsa041421.80196462
15Oxidative phosphorylation_Homo sapiens_hsa001901.79328984
16Insulin secretion_Homo sapiens_hsa049111.75728055
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.65433033
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64344869
19Propanoate metabolism_Homo sapiens_hsa006401.59622785
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49956482
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42688016
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41478831
23Synaptic vesicle cycle_Homo sapiens_hsa047211.38179396
24Type II diabetes mellitus_Homo sapiens_hsa049301.36012769
25Nicotine addiction_Homo sapiens_hsa050331.34751486
26Protein digestion and absorption_Homo sapiens_hsa049741.33642905
27Parkinsons disease_Homo sapiens_hsa050121.32854987
28N-Glycan biosynthesis_Homo sapiens_hsa005101.27063484
29Prion diseases_Homo sapiens_hsa050201.24140656
30Adherens junction_Homo sapiens_hsa045201.23827821
31Selenocompound metabolism_Homo sapiens_hsa004501.21205366
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19939650
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.19159480
34Fat digestion and absorption_Homo sapiens_hsa049751.18407928
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.15802225
36Pyruvate metabolism_Homo sapiens_hsa006201.14892731
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.14764648
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14233084
39Bladder cancer_Homo sapiens_hsa052191.12933894
40Pancreatic secretion_Homo sapiens_hsa049721.12690755
41Peroxisome_Homo sapiens_hsa041461.12482094
42Thyroid hormone synthesis_Homo sapiens_hsa049181.11190374
43GABAergic synapse_Homo sapiens_hsa047271.10537095
44Glutathione metabolism_Homo sapiens_hsa004801.09372330
45Collecting duct acid secretion_Homo sapiens_hsa049661.07475971
46Carbon metabolism_Homo sapiens_hsa012001.04205380
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01285724
48Thyroid cancer_Homo sapiens_hsa052160.99865896
49Galactose metabolism_Homo sapiens_hsa000520.99688415
50Butanoate metabolism_Homo sapiens_hsa006500.99602714
51Folate biosynthesis_Homo sapiens_hsa007900.98279318
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96389219
53Renin-angiotensin system_Homo sapiens_hsa046140.96031619
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95782437
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95653722
56Insulin resistance_Homo sapiens_hsa049310.95000288
57Cocaine addiction_Homo sapiens_hsa050300.92844795
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90845972
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90640075
60Tryptophan metabolism_Homo sapiens_hsa003800.88847839
61Mineral absorption_Homo sapiens_hsa049780.87898500
62Starch and sucrose metabolism_Homo sapiens_hsa005000.87605224
63Fatty acid metabolism_Homo sapiens_hsa012120.87389411
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84316974
65Huntingtons disease_Homo sapiens_hsa050160.84242436
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83521405
67Arginine and proline metabolism_Homo sapiens_hsa003300.82816429
68Estrogen signaling pathway_Homo sapiens_hsa049150.81606718
69Biosynthesis of amino acids_Homo sapiens_hsa012300.81457146
70Phagosome_Homo sapiens_hsa041450.80232020
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80222614
72Alzheimers disease_Homo sapiens_hsa050100.79892255
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79420040
74Glucagon signaling pathway_Homo sapiens_hsa049220.79356885
75Focal adhesion_Homo sapiens_hsa045100.79208402
76Proteoglycans in cancer_Homo sapiens_hsa052050.78380502
77Hippo signaling pathway_Homo sapiens_hsa043900.78357259
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78239685
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77629849
80Endometrial cancer_Homo sapiens_hsa052130.77387263
81beta-Alanine metabolism_Homo sapiens_hsa004100.77137462
82Arginine biosynthesis_Homo sapiens_hsa002200.76523097
83Insulin signaling pathway_Homo sapiens_hsa049100.76507385
84Fatty acid degradation_Homo sapiens_hsa000710.74680011
85Dopaminergic synapse_Homo sapiens_hsa047280.74635373
86Basal transcription factors_Homo sapiens_hsa030220.73967413
87mTOR signaling pathway_Homo sapiens_hsa041500.73786058
88Renal cell carcinoma_Homo sapiens_hsa052110.72136961
89Amphetamine addiction_Homo sapiens_hsa050310.71687942
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70785210
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69597952
92Prolactin signaling pathway_Homo sapiens_hsa049170.67281309
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.67180393
94Bile secretion_Homo sapiens_hsa049760.65294228
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.64574912
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64532958
97Vitamin B6 metabolism_Homo sapiens_hsa007500.64466298
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64080784
99Phenylalanine metabolism_Homo sapiens_hsa003600.63964631
100Amoebiasis_Homo sapiens_hsa051460.63123385
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.62219907
102Tight junction_Homo sapiens_hsa045300.62157373
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61876357
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61058843
105Complement and coagulation cascades_Homo sapiens_hsa046100.60987777
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59967365
107Metabolic pathways_Homo sapiens_hsa011000.59886161
108Salmonella infection_Homo sapiens_hsa051320.59542812
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58900985
110ECM-receptor interaction_Homo sapiens_hsa045120.58640241
111PPAR signaling pathway_Homo sapiens_hsa033200.57873125
112Oocyte meiosis_Homo sapiens_hsa041140.57591723
113Other glycan degradation_Homo sapiens_hsa005110.57258019
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57136968
115Caffeine metabolism_Homo sapiens_hsa002320.56114941
116Long-term potentiation_Homo sapiens_hsa047200.56014020
117Type I diabetes mellitus_Homo sapiens_hsa049400.55891976
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55550120
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55367790
120Glioma_Homo sapiens_hsa052140.55254517
121Circadian rhythm_Homo sapiens_hsa047100.53199953
122Shigellosis_Homo sapiens_hsa051310.51902018
123Endocytosis_Homo sapiens_hsa041440.51399979
124AMPK signaling pathway_Homo sapiens_hsa041520.51288473
125Regulation of autophagy_Homo sapiens_hsa041400.51142242
126Chemical carcinogenesis_Homo sapiens_hsa052040.49754802
127Ether lipid metabolism_Homo sapiens_hsa005650.49221691
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48621432
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48119350
130Gap junction_Homo sapiens_hsa045400.45578873
131Prostate cancer_Homo sapiens_hsa052150.45481681
132Histidine metabolism_Homo sapiens_hsa003400.45275509
133Axon guidance_Homo sapiens_hsa043600.45054314
134Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43341537
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.42159284
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41784313
137Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41512358
138Colorectal cancer_Homo sapiens_hsa052100.40705624
139AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39781802
140TGF-beta signaling pathway_Homo sapiens_hsa043500.39394439
141Pancreatic cancer_Homo sapiens_hsa052120.39095379
142Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38796686
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38081384
144Melanogenesis_Homo sapiens_hsa049160.37380765
145Dorso-ventral axis formation_Homo sapiens_hsa043200.37148938
146Fructose and mannose metabolism_Homo sapiens_hsa000510.37044985
147Sphingolipid metabolism_Homo sapiens_hsa006000.36150209
148Chronic myeloid leukemia_Homo sapiens_hsa052200.35054567
149Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34707989
150FoxO signaling pathway_Homo sapiens_hsa040680.33627852

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