RAB18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)4.67562363
2Golgi transport vesicle coating (GO:0048200)4.16897115
3COPI coating of Golgi vesicle (GO:0048205)4.16897115
4presynaptic membrane assembly (GO:0097105)4.16194752
5DNA double-strand break processing (GO:0000729)4.10710165
6long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.69690165
7platelet dense granule organization (GO:0060155)3.64931456
8protein localization to cilium (GO:0061512)3.61052472
9keratinocyte development (GO:0003334)3.56259266
10presynaptic membrane organization (GO:0097090)3.55461573
11fatty-acyl-CoA biosynthetic process (GO:0046949)3.51868750
12long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.46069344
13thioester biosynthetic process (GO:0035384)3.44268327
14acyl-CoA biosynthetic process (GO:0071616)3.44268327
15fatty-acyl-CoA metabolic process (GO:0035337)3.33321018
16positive regulation of mitochondrial fission (GO:0090141)3.28871342
17proteasome assembly (GO:0043248)3.25649795
18intraciliary transport (GO:0042073)3.25074252
19chaperone-mediated protein transport (GO:0072321)3.16321261
20nonmotile primary cilium assembly (GO:0035058)3.15980836
21L-phenylalanine catabolic process (GO:0006559)3.15376833
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.15376833
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.12062430
24signal peptide processing (GO:0006465)3.10963805
25glycosphingolipid biosynthetic process (GO:0006688)3.10820772
26neuron cell-cell adhesion (GO:0007158)3.04916401
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.02689168
28cilium morphogenesis (GO:0060271)2.96067840
29succinate metabolic process (GO:0006105)2.94640392
30positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.90700457
31peroxisome fission (GO:0016559)2.90007670
32protein retention in ER lumen (GO:0006621)2.89141296
33peptidyl-cysteine modification (GO:0018198)2.88349480
34cellular ketone body metabolic process (GO:0046950)2.87802824
35L-phenylalanine metabolic process (GO:0006558)2.86632384
36erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.86632384
37cullin deneddylation (GO:0010388)2.86331170
38maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.83021295
39water-soluble vitamin biosynthetic process (GO:0042364)2.81280414
40energy coupled proton transport, down electrochemical gradient (GO:0015985)2.80342239
41ATP synthesis coupled proton transport (GO:0015986)2.80342239
42regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.80323724
43negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.78441968
44establishment of melanosome localization (GO:0032401)2.77452104
45melanosome transport (GO:0032402)2.76100730
46axon ensheathment in central nervous system (GO:0032291)2.75322872
47central nervous system myelination (GO:0022010)2.75322872
48gamma-aminobutyric acid transport (GO:0015812)2.73513273
49very long-chain fatty acid metabolic process (GO:0000038)2.71971772
50regulation of cilium movement (GO:0003352)2.70107581
51regulation of hexokinase activity (GO:1903299)2.69197848
52regulation of glucokinase activity (GO:0033131)2.69197848
53protein neddylation (GO:0045116)2.68782982
54negative regulation of synaptic transmission, GABAergic (GO:0032229)2.66818591
55cholesterol biosynthetic process (GO:0006695)2.66800628
56inositol phosphate catabolic process (GO:0071545)2.65850705
57magnesium ion transport (GO:0015693)2.65126911
58cellular copper ion homeostasis (GO:0006878)2.64692336
59C4-dicarboxylate transport (GO:0015740)2.62432383
60heme transport (GO:0015886)2.61267149
61negative regulation of DNA recombination (GO:0045910)2.59796462
62synaptic vesicle exocytosis (GO:0016079)2.59424887
63respiratory electron transport chain (GO:0022904)2.59412325
64energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.59365443
65ATP hydrolysis coupled proton transport (GO:0015991)2.59365443
66thioester metabolic process (GO:0035383)2.58871002
67acyl-CoA metabolic process (GO:0006637)2.58871002
68tricarboxylic acid cycle (GO:0006099)2.58175633
69establishment of pigment granule localization (GO:0051905)2.57395395
70regulation of metalloenzyme activity (GO:0048552)2.56661568
71pyrimidine nucleobase catabolic process (GO:0006208)2.55932905
72protein targeting to Golgi (GO:0000042)2.55638856
73pigment granule transport (GO:0051904)2.55193779
74positive regulation of amino acid transport (GO:0051957)2.54822661
75electron transport chain (GO:0022900)2.54355299
76branched-chain amino acid catabolic process (GO:0009083)2.53608772
77limb bud formation (GO:0060174)2.53049720
78protein deneddylation (GO:0000338)2.52485108
79intra-Golgi vesicle-mediated transport (GO:0006891)2.52359721
80calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.51718928
81negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.50517098
82organelle disassembly (GO:1903008)2.50505379
83cofactor catabolic process (GO:0051187)2.49121726
84COPII vesicle coating (GO:0048208)2.48571715
85histone H2A acetylation (GO:0043968)2.48501986
86melanosome localization (GO:0032400)2.48480341
87vocalization behavior (GO:0071625)2.46887472
88pH reduction (GO:0045851)2.46520040
89respiratory chain complex IV assembly (GO:0008535)2.46368915
90mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.45929448
91pyrimidine-containing compound transmembrane transport (GO:0072531)2.45539707
92neural tube formation (GO:0001841)2.45089227
93ER overload response (GO:0006983)2.44873141
94L-serine transport (GO:0015825)2.44727965
95regulation of acyl-CoA biosynthetic process (GO:0050812)2.44264367
96regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.44011752
97peptidyl-histidine modification (GO:0018202)2.43994928
98toxin metabolic process (GO:0009404)2.43352734
99regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.43038173
100regulation of mitotic spindle checkpoint (GO:1903504)2.43038173
101copper ion homeostasis (GO:0055070)2.42544003
102sterol biosynthetic process (GO:0016126)2.42433220
103establishment of protein localization to Golgi (GO:0072600)2.41603428
104negative regulation of membrane potential (GO:0045837)2.41302664
105anterograde synaptic vesicle transport (GO:0048490)2.40790158
106substantia nigra development (GO:0021762)2.40671005
107positive regulation of protein autophosphorylation (GO:0031954)2.39793164
108nucleobase catabolic process (GO:0046113)2.38549110
109GPI anchor metabolic process (GO:0006505)2.38301014
110vascular smooth muscle contraction (GO:0014829)2.37826679
111protein localization to Golgi apparatus (GO:0034067)2.37785600
112cilium assembly (GO:0042384)2.37301278
113type B pancreatic cell proliferation (GO:0044342)2.36931257
114cilium organization (GO:0044782)2.36425655
115isoprenoid biosynthetic process (GO:0008299)2.35950905
116ketone body metabolic process (GO:1902224)2.35406991
117inositol phosphate dephosphorylation (GO:0046855)2.34808647
118phosphorylated carbohydrate dephosphorylation (GO:0046838)2.34808647
119aspartate family amino acid catabolic process (GO:0009068)2.34677365
120startle response (GO:0001964)2.34652018
121ER to Golgi vesicle-mediated transport (GO:0006888)2.32863068
122ribonucleoprotein complex disassembly (GO:0032988)2.32499505
123NADH metabolic process (GO:0006734)2.32432428
124membrane budding (GO:0006900)2.31989993
125pigment granule localization (GO:0051875)2.31187039
126alpha-linolenic acid metabolic process (GO:0036109)2.30639662
127peroxisome organization (GO:0007031)2.30288275
128coenzyme catabolic process (GO:0009109)2.29897642
129peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.29019180
130glycolipid biosynthetic process (GO:0009247)2.28968472
131transferrin transport (GO:0033572)2.28958984
132retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.28940768
133negative regulation of neurological system process (GO:0031645)2.27785897
134intracellular pH reduction (GO:0051452)2.26935854
135glial cell proliferation (GO:0014009)2.26541708
136DNA damage response, detection of DNA damage (GO:0042769)2.26423672
137trivalent inorganic cation transport (GO:0072512)2.25275345
138ferric iron transport (GO:0015682)2.25275345
139C-terminal protein lipidation (GO:0006501)2.24912655
140regulation of cofactor metabolic process (GO:0051193)2.24401557
141regulation of coenzyme metabolic process (GO:0051196)2.24401557
142proline transport (GO:0015824)2.23769682
143dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.23739882
144response to pheromone (GO:0019236)2.23060094
145vesicle coating (GO:0006901)2.22437413
146protein K11-linked ubiquitination (GO:0070979)2.22326300
147mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.21789053
148positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.21789053
149regulation of synaptic vesicle exocytosis (GO:2000300)2.21381770
150L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.20625368
151protein maturation by protein folding (GO:0022417)2.20615947
152C-terminal protein amino acid modification (GO:0018410)2.19711699
153nucleotide transmembrane transport (GO:1901679)2.19533351
154oxaloacetate metabolic process (GO:0006107)2.18931006
155postsynaptic membrane organization (GO:0001941)2.18928034
156branched-chain amino acid metabolic process (GO:0009081)2.18764806
157regulation of feeding behavior (GO:0060259)2.18048435
158zinc ion transport (GO:0006829)2.17295266
159preassembly of GPI anchor in ER membrane (GO:0016254)2.16190015
160glutathione biosynthetic process (GO:0006750)2.15893800
161L-methionine salvage (GO:0071267)2.13432439
162L-methionine biosynthetic process (GO:0071265)2.13432439
163amino acid salvage (GO:0043102)2.13432439
164lysine catabolic process (GO:0006554)2.12786462
165lysine metabolic process (GO:0006553)2.12786462
166iron coordination entity transport (GO:1901678)2.11541374
167neuronal action potential propagation (GO:0019227)2.06446993
168glycerol ether metabolic process (GO:0006662)2.05720754
169negative regulation of cation channel activity (GO:2001258)2.05139236
170positive regulation of actin filament depolymerization (GO:0030836)2.03165191
171dicarboxylic acid catabolic process (GO:0043649)2.03016079
172transcytosis (GO:0045056)2.02224907
173negative regulation of fibrinolysis (GO:0051918)2.01170760
174regulation of sulfur metabolic process (GO:0042762)2.00406820
175apical protein localization (GO:0045176)1.99883362
176nonribosomal peptide biosynthetic process (GO:0019184)1.99507831
177aldehyde catabolic process (GO:0046185)1.98981868

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.54610167
2RBPJ_22232070_ChIP-Seq_NCS_Mouse2.54878955
3IGF1R_20145208_ChIP-Seq_DFB_Human2.47729635
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.46468597
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.41590223
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26638525
7TAF15_26573619_Chip-Seq_HEK293_Human2.20635213
8EWS_26573619_Chip-Seq_HEK293_Human2.19920495
9CLOCK_20551151_ChIP-Seq_293T_Human2.12074747
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.08863690
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.06463085
12NRF2_20460467_ChIP-Seq_MEFs_Mouse2.01484955
13NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.01484955
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.01339057
15WT1_19549856_ChIP-ChIP_CCG9911_Human1.96962128
16GBX2_23144817_ChIP-Seq_PC3_Human1.96329325
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.96307585
18ELK1_19687146_ChIP-ChIP_HELA_Human1.96135525
19* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89476867
20GATA1_22025678_ChIP-Seq_K562_Human1.84511695
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.82439746
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77770744
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.75615964
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75496336
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70225241
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67777754
27MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.67056844
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67003859
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66498143
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65736030
31* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63495406
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.63344757
33VDR_22108803_ChIP-Seq_LS180_Human1.63180449
34* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62487007
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.61923809
36SOX2_20726797_ChIP-Seq_SW620_Human1.58760822
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58147701
38* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57433982
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56960890
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.56543665
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.54892238
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.52102322
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50863575
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50512424
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.50495936
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.50218067
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.49038000
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46026325
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45421866
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45290025
51ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.44210191
52AR_21572438_ChIP-Seq_LNCaP_Human1.42647275
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41825036
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41205090
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40118581
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38737496
57P300_19829295_ChIP-Seq_ESCs_Human1.38343478
58EST1_17652178_ChIP-ChIP_JURKAT_Human1.37105889
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36793428
60RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36793428
61MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36182483
62FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35363523
63HTT_18923047_ChIP-ChIP_STHdh_Human1.34407339
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33782292
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.33406259
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33019524
67SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.32297529
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31523808
69* STAT3_23295773_ChIP-Seq_U87_Human1.30156328
70CJUN_26792858_Chip-Seq_BT549_Human1.30036537
71ZNF274_21170338_ChIP-Seq_K562_Hela1.29618150
72EZH2_27304074_Chip-Seq_ESCs_Mouse1.29604653
73P53_22387025_ChIP-Seq_ESCs_Mouse1.28127134
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.26795239
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24567389
76TCF4_22108803_ChIP-Seq_LS180_Human1.24484253
77JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22903154
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22609990
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.22160797
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21527478
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21001303
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20128256
83FUS_26573619_Chip-Seq_HEK293_Human1.19146723
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17669305
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.16931462
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16848514
87RUNX2_22187159_ChIP-Seq_PCA_Human1.16518373
88CDX2_22108803_ChIP-Seq_LS180_Human1.16501888
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16306381
90NANOG_19829295_ChIP-Seq_ESCs_Human1.15598891
91SOX2_19829295_ChIP-Seq_ESCs_Human1.15598891
92ESR2_21235772_ChIP-Seq_MCF-7_Human1.15513243
93SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15466307
94TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14029318
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13949888
96LXR_22158963_ChIP-Seq_LIVER_Mouse1.13949497
97E2F1_18555785_Chip-Seq_ESCs_Mouse1.13915192
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13470400
99ESR1_20079471_ChIP-ChIP_T-47D_Human1.12627053
100TP53_18474530_ChIP-ChIP_U2OS_Human1.12550602
101FLI1_21867929_ChIP-Seq_TH2_Mouse1.12313540
102NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11465153
103P300_18555785_Chip-Seq_ESCs_Mouse1.11303906
104FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10689439
105CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10580873
106* EOMES_21245162_ChIP-Seq_HESCs_Human1.10353858
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.09983850
108TCF4_23295773_ChIP-Seq_U87_Human1.09883781
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.09062985
110ER_23166858_ChIP-Seq_MCF-7_Human1.08375848
111ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08274811
112TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08254098
113* REST_19997604_ChIP-ChIP_NEURONS_Mouse1.07672548
114CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07618627
115SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07198724
116STAT3_18555785_Chip-Seq_ESCs_Mouse1.07101759
117KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06456810
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05699279
119RNF2_27304074_Chip-Seq_NSC_Mouse1.05291578
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04589536
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04040483
122* VDR_23849224_ChIP-Seq_CD4+_Human1.03705784
123* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03696335
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03520339
125EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03113999
126* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02275867
127SOX2_18555785_Chip-Seq_ESCs_Mouse1.01402022
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00839812
129OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00516934
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00281402
131SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99784438
132SMAD3_21741376_ChIP-Seq_EPCs_Human0.99754532
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99494434
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99450479
135NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98158457
136ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97826812
137GABP_17652178_ChIP-ChIP_JURKAT_Human0.96891388
138MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96396395
139SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94408877
140EZH2_27294783_Chip-Seq_ESCs_Mouse0.90727886
141AR_25329375_ChIP-Seq_VCAP_Human0.90420167
142CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89790979
143SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.89250264
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87882282
145BCAT_22108803_ChIP-Seq_LS180_Human0.85563560
146HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85065313
147* SMAD4_21799915_ChIP-Seq_A2780_Human0.84638398
148JUN_21703547_ChIP-Seq_K562_Human0.84170789
149PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83189747
150KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83102556
151IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82379514
152CBP_20019798_ChIP-Seq_JUKART_Human0.82379514
153SOX17_20123909_ChIP-Seq_XEN_Mouse0.81707977

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.20232744
2MP0001984_abnormal_olfaction2.98763804
3MP0002102_abnormal_ear_morphology2.96037838
4MP0008438_abnormal_cutaneous_collagen2.70080218
5MP0003880_abnormal_central_pattern2.63257799
6MP0009780_abnormal_chondrocyte_physiolo2.42525839
7MP0005275_abnormal_skin_tensile2.38766735
8MP0000013_abnormal_adipose_tissue2.33544532
9MP0003806_abnormal_nucleotide_metabolis2.31828660
10MP0006072_abnormal_retinal_apoptosis2.23956594
11MP0005360_urolithiasis2.22043928
12MP0008789_abnormal_olfactory_epithelium2.07871272
13MP0005503_abnormal_tendon_morphology2.02504053
14MP0002139_abnormal_hepatobiliary_system1.95486292
15MP0005085_abnormal_gallbladder_physiolo1.93034602
16MP0005253_abnormal_eye_physiology1.92439187
17MP0000516_abnormal_urinary_system1.92315964
18MP0005367_renal/urinary_system_phenotyp1.92315964
19MP0004272_abnormal_basement_membrane1.92309063
20MP0003011_delayed_dark_adaptation1.90945419
21MP0005083_abnormal_biliary_tract1.89537232
22MP0003329_amyloid_beta_deposits1.88168801
23MP0005499_abnormal_olfactory_system1.86746548
24MP0005394_taste/olfaction_phenotype1.86746548
25MP0004270_analgesia1.85454310
26MP0005248_abnormal_Harderian_gland1.84670691
27MP0003890_abnormal_embryonic-extraembry1.84602461
28MP0001881_abnormal_mammary_gland1.81665022
29MP0004147_increased_porphyrin_level1.80507289
30MP0001188_hyperpigmentation1.79048020
31MP0008875_abnormal_xenobiotic_pharmacok1.69840741
32MP0009046_muscle_twitch1.69362300
33MP0006054_spinal_hemorrhage1.69116858
34MP0005187_abnormal_penis_morphology1.67747170
35MP0005084_abnormal_gallbladder_morpholo1.67664450
36MP0001529_abnormal_vocalization1.64941863
37MP0001542_abnormal_bone_strength1.62044467
38MP0002751_abnormal_autonomic_nervous1.59590831
39MP0008877_abnormal_DNA_methylation1.58594242
40MP0000647_abnormal_sebaceous_gland1.57584891
41MP0009384_cardiac_valve_regurgitation1.54610742
42MP0002254_reproductive_system_inflammat1.54543722
43MP0001486_abnormal_startle_reflex1.52948632
44MP0010234_abnormal_vibrissa_follicle1.51173920
45MP0005379_endocrine/exocrine_gland_phen1.50142780
46MP0006276_abnormal_autonomic_nervous1.49659114
47MP0004043_abnormal_pH_regulation1.49184118
48MP0002163_abnormal_gland_morphology1.46142032
49MP0009745_abnormal_behavioral_response1.45894813
50MP0002090_abnormal_vision1.43756056
51MP0001905_abnormal_dopamine_level1.40852444
52MP0002233_abnormal_nose_morphology1.38510793
53MP0000427_abnormal_hair_cycle1.38020317
54MP0003656_abnormal_erythrocyte_physiolo1.36900521
55MP0005551_abnormal_eye_electrophysiolog1.36797462
56MP0002638_abnormal_pupillary_reflex1.36697376
57MP0005365_abnormal_bile_salt1.34762923
58MP0003941_abnormal_skin_development1.30319055
59MP0004133_heterotaxia1.28437743
60MP0003121_genomic_imprinting1.28320849
61MP0001177_atelectasis1.26919744
62MP0005332_abnormal_amino_acid1.26047275
63MP0000372_irregular_coat_pigmentation1.24642417
64MP0003122_maternal_imprinting1.23963493
65MP0003183_abnormal_peptide_metabolism1.23729034
66MP0002877_abnormal_melanocyte_morpholog1.22900233
67MP0002909_abnormal_adrenal_gland1.20558671
68MP0003787_abnormal_imprinting1.20412967
69MP0005408_hypopigmentation1.20387064
70MP0002234_abnormal_pharynx_morphology1.18910579
71MP0002295_abnormal_pulmonary_circulatio1.15608018
72MP0002734_abnormal_mechanical_nocicepti1.15057027
73MP0002837_dystrophic_cardiac_calcinosis1.13826804
74MP0003937_abnormal_limbs/digits/tail_de1.13262667
75MP0003119_abnormal_digestive_system1.13062116
76MP0008058_abnormal_DNA_repair1.12345037
77MP0002557_abnormal_social/conspecific_i1.11038591
78MP0000751_myopathy1.10839427
79MP0004036_abnormal_muscle_relaxation1.09866928
80MP0004859_abnormal_synaptic_plasticity1.08996816
81MP0003137_abnormal_impulse_conducting1.08592937
82MP0002796_impaired_skin_barrier1.07887121
83MP0010678_abnormal_skin_adnexa1.07045008
84MP0000920_abnormal_myelination1.06779912
85MP0009697_abnormal_copulation1.06268649
86MP0003718_maternal_effect1.04806257
87MP0002184_abnormal_innervation1.04741800
88MP0003136_yellow_coat_color1.04449956
89MP0004924_abnormal_behavior1.03425186
90MP0005386_behavior/neurological_phenoty1.03425186
91MP0005165_increased_susceptibility_to1.02940463
92MP0000230_abnormal_systemic_arterial1.02148614
93MP0002064_seizures1.01863107
94MP0001666_abnormal_nutrient_absorption1.01815010
95MP0005646_abnormal_pituitary_gland1.01797053
96MP0005508_abnormal_skeleton_morphology1.01795926
97MP0001958_emphysema1.01703367
98MP0002272_abnormal_nervous_system1.01696054
99MP0001299_abnormal_eye_distance/1.01520279
100MP0003635_abnormal_synaptic_transmissio1.00818328
101MP0005623_abnormal_meninges_morphology0.99946033
102MP0004085_abnormal_heartbeat0.99447683
103MP0006036_abnormal_mitochondrial_physio0.99106383
104MP0009379_abnormal_foot_pigmentation0.98202613
105MP0003950_abnormal_plasma_membrane0.98038414
106MP0002896_abnormal_bone_mineralization0.96736742
107MP0005595_abnormal_vascular_smooth0.95617977
108MP0005164_abnormal_response_to0.94500606
109MP0010386_abnormal_urinary_bladder0.94134531
110MP0002282_abnormal_trachea_morphology0.93744283
111MP0004130_abnormal_muscle_cell0.93517656
112MP0004885_abnormal_endolymph0.93408620
113MP0002332_abnormal_exercise_endurance0.92100389
114MP0003755_abnormal_palate_morphology0.91686411
115MP0004484_altered_response_of0.91665685
116MP0005391_vision/eye_phenotype0.91124550
117MP0003191_abnormal_cellular_cholesterol0.91055082
118MP0001764_abnormal_homeostasis0.90301780
119MP0005423_abnormal_somatic_nervous0.90113010
120MP0005171_absent_coat_pigmentation0.89761719
121MP0000631_abnormal_neuroendocrine_gland0.89712581
122MP0008260_abnormal_autophagy0.88986932
123MP0001501_abnormal_sleep_pattern0.88948652
124MP0005636_abnormal_mineral_homeostasis0.88424827
125MP0003634_abnormal_glial_cell0.86929955
126MP0004215_abnormal_myocardial_fiber0.86119464
127MP0000747_muscle_weakness0.85797562
128MP0000049_abnormal_middle_ear0.84673289
129MP0003705_abnormal_hypodermis_morpholog0.84561391
130MP0002118_abnormal_lipid_homeostasis0.83931588
131MP0003690_abnormal_glial_cell0.83820436
132MP0002822_catalepsy0.83508863
133MP0002067_abnormal_sensory_capabilities0.82856635
134MP0002063_abnormal_learning/memory/cond0.81921749
135MP0003567_abnormal_fetal_cardiomyocyte0.81763713
136MP0000604_amyloidosis0.81747903
137MP0003186_abnormal_redox_activity0.80348087
138MP0002736_abnormal_nociception_after0.78983916
139MP0002572_abnormal_emotion/affect_behav0.78416771
140MP0002735_abnormal_chemical_nociception0.78120619
141MP0001440_abnormal_grooming_behavior0.77935697
142MP0003221_abnormal_cardiomyocyte_apopto0.77909583
143MP0001968_abnormal_touch/_nociception0.77903526
144MP0000569_abnormal_digit_pigmentation0.77290631
145MP0004811_abnormal_neuron_physiology0.76402543
146MP0004142_abnormal_muscle_tone0.76224002
147MP0000778_abnormal_nervous_system0.75561261
148MP0009250_abnormal_appendicular_skeleto0.75077018
149MP0005535_abnormal_body_temperature0.74269377
150MP0001664_abnormal_digestion0.74224516
151MP0000681_abnormal_thyroid_gland0.73629915
152MP0000163_abnormal_cartilage_morphology0.73156947
153MP0002752_abnormal_somatic_nervous0.73071827
154MP0003385_abnormal_body_wall0.72963893
155MP0004145_abnormal_muscle_electrophysio0.72961260
156MP0002108_abnormal_muscle_morphology0.72508631
157MP0001970_abnormal_pain_threshold0.72338271
158MP0000639_abnormal_adrenal_gland0.72023927
159MP0002876_abnormal_thyroid_physiology0.71475184
160MP0001879_abnormal_lymphatic_vessel0.71352055
161MP0002069_abnormal_eating/drinking_beha0.69476461
162MP0003633_abnormal_nervous_system0.69391529
163MP0005195_abnormal_posterior_eye0.68991943
164MP0002882_abnormal_neuron_morphology0.67108112

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolysis (HP:0004366)4.10510924
2Increased serum pyruvate (HP:0003542)4.10510924
3Medial flaring of the eyebrow (HP:0010747)3.58011747
4Gait imbalance (HP:0002141)3.57439201
5Acute necrotizing encephalopathy (HP:0006965)3.54230594
6Pheochromocytoma (HP:0002666)3.54124456
7Congenital primary aphakia (HP:0007707)3.49858347
8Abnormal mitochondria in muscle tissue (HP:0008316)3.39977883
9Neuroendocrine neoplasm (HP:0100634)3.39062514
10Nephrogenic diabetes insipidus (HP:0009806)3.24103367
11Acute encephalopathy (HP:0006846)3.21228274
12Genital tract atresia (HP:0001827)3.04140153
13Abnormality of aromatic amino acid family metabolism (HP:0004338)3.00802503
14Vaginal atresia (HP:0000148)2.94287350
15Progressive macrocephaly (HP:0004481)2.93472518
16Progressive inability to walk (HP:0002505)2.75211319
17Renal cortical cysts (HP:0000803)2.68547858
18Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.68276151
19Autoamputation (HP:0001218)2.57435404
20Neurofibrillary tangles (HP:0002185)2.55961087
21True hermaphroditism (HP:0010459)2.53190324
22Hepatic necrosis (HP:0002605)2.52728859
23Hyperglycinemia (HP:0002154)2.45689022
24Gout (HP:0001997)2.42490480
25Mitochondrial inheritance (HP:0001427)2.41948848
26Hepatocellular necrosis (HP:0001404)2.41712989
27Pancreatic cysts (HP:0001737)2.41281022
28Hypothermia (HP:0002045)2.38708325
29Cerebral edema (HP:0002181)2.33401828
30Pancreatic fibrosis (HP:0100732)2.31680755
31Parakeratosis (HP:0001036)2.31340168
32Cerebral hemorrhage (HP:0001342)2.29652087
33Absent speech (HP:0001344)2.23265079
34Intestinal atresia (HP:0011100)2.21097318
35Protuberant abdomen (HP:0001538)2.18864086
36Inability to walk (HP:0002540)2.18504149
37Increased CSF lactate (HP:0002490)2.17614462
38Premature rupture of membranes (HP:0001788)2.15761659
39Drooling (HP:0002307)2.15199761
40Poor coordination (HP:0002370)2.12763837
41Abnormality of midbrain morphology (HP:0002418)2.11813019
42Molar tooth sign on MRI (HP:0002419)2.11813019
43Ketoacidosis (HP:0001993)2.11544258
44Atonic seizures (HP:0010819)2.11512094
45Polyphagia (HP:0002591)2.11462647
46Protrusio acetabuli (HP:0003179)2.11267753
47Specific learning disability (HP:0001328)2.11154293
48Abnormality of vitamin B metabolism (HP:0004340)2.10459095
49Cortical dysplasia (HP:0002539)2.05737290
50Vascular tortuosity (HP:0004948)2.03871143
51Hypoglycemic coma (HP:0001325)2.03563708
52Short tibia (HP:0005736)2.03539395
53Agitation (HP:0000713)2.03303631
54Postaxial hand polydactyly (HP:0001162)2.03279204
55Nephronophthisis (HP:0000090)2.03219941
56Hypoglycemic seizures (HP:0002173)2.02772277
57Abnormality of the intrinsic pathway (HP:0010989)2.02648685
58Thyroid carcinoma (HP:0002890)2.01797493
59Hemiparesis (HP:0001269)2.01165413
60Tubulointerstitial nephritis (HP:0001970)2.00419851
61Hypsarrhythmia (HP:0002521)2.00225886
62Split foot (HP:0001839)2.00093316
63Leukodystrophy (HP:0002415)1.99825381
64Papillary thyroid carcinoma (HP:0002895)1.99714730
65Congenital ichthyosiform erythroderma (HP:0007431)1.99576997
66EEG with generalized epileptiform discharges (HP:0011198)1.99244989
67X-linked dominant inheritance (HP:0001423)1.99188452
68Aplasia/Hypoplasia of the tibia (HP:0005772)1.98232459
69Broad foot (HP:0001769)1.97633582
70Conjunctival hamartoma (HP:0100780)1.96068552
71Hyperinsulinemic hypoglycemia (HP:0000825)1.94728535
72Metaphyseal dysplasia (HP:0100255)1.94658171
73Epileptiform EEG discharges (HP:0011182)1.94111324
74Abnormality of the vitamin B12 metabolism (HP:0004341)1.93561083
75Beaking of vertebral bodies (HP:0004568)1.93089692
76Abnormal protein glycosylation (HP:0012346)1.91856729
77Abnormal glycosylation (HP:0012345)1.91856729
78Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91856729
79Abnormal protein N-linked glycosylation (HP:0012347)1.91856729
80Abnormality of the musculature of the pelvis (HP:0001469)1.88320463
81Abnormality of the hip-girdle musculature (HP:0001445)1.88320463
82Abnormality of macular pigmentation (HP:0008002)1.87586877
83Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.87377627
84Excessive salivation (HP:0003781)1.86704612
85Abolished electroretinogram (ERG) (HP:0000550)1.86569605
86Aplasia/Hypoplasia of the lens (HP:0008063)1.86535270
87Bifid tongue (HP:0010297)1.86151766
88Atrophy/Degeneration involving motor neurons (HP:0007373)1.86033765
89Cerebral inclusion bodies (HP:0100314)1.85671251
90Amyotrophic lateral sclerosis (HP:0007354)1.85633675
91Hyperventilation (HP:0002883)1.85035485
92Lissencephaly (HP:0001339)1.84400374
933-Methylglutaconic aciduria (HP:0003535)1.84022996
94Neoplasm of the adrenal gland (HP:0100631)1.83976050
95Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.83547020
96Glioma (HP:0009733)1.82669261
97Abnormality of serum amino acid levels (HP:0003112)1.82452125
98Generalized aminoaciduria (HP:0002909)1.82347252
99Aplasia/Hypoplasia of the tongue (HP:0010295)1.81772850
100Disproportionate short-trunk short stature (HP:0003521)1.80668371
101Xanthomatosis (HP:0000991)1.80328556
102Abnormal gallbladder morphology (HP:0012437)1.80254710
103Arterial tortuosity (HP:0005116)1.80086382
104Adrenal hypoplasia (HP:0000835)1.79837463
105Abnormality of the metopic suture (HP:0005556)1.79813212
106Hypoplastic pelvis (HP:0008839)1.79415077
107Abnormality of the astrocytes (HP:0100707)1.79232749
108Astrocytoma (HP:0009592)1.79232749
109Abnormality of the labia minora (HP:0012880)1.79128772
110Delayed gross motor development (HP:0002194)1.78511320
111Epiphyseal stippling (HP:0010655)1.78416075
112Lethargy (HP:0001254)1.77959458
113Exercise-induced muscle cramps (HP:0003710)1.76697955
114Humeroradial synostosis (HP:0003041)1.76321698
115Synostosis involving the elbow (HP:0003938)1.76321698
116Abnormality of the renal cortex (HP:0011035)1.76280998
117* Muscular hypotonia of the trunk (HP:0008936)1.75672252
118Lactic acidosis (HP:0003128)1.75631989
119Methylmalonic aciduria (HP:0012120)1.74976286
120Action tremor (HP:0002345)1.74549381
121Mitral stenosis (HP:0001718)1.73950583
122Abnormality of fatty-acid metabolism (HP:0004359)1.73334384
123Torticollis (HP:0000473)1.73156701
124Myokymia (HP:0002411)1.72981072
125Sensory axonal neuropathy (HP:0003390)1.72385573
126Abnormal epiphyseal ossification (HP:0010656)1.71809800
127Poor suck (HP:0002033)1.71387838
128Febrile seizures (HP:0002373)1.71151256
129Increased hepatocellular lipid droplets (HP:0006565)1.70391032
130Increased neuronal autofluorescent lipopigment (HP:0002074)1.70043320
131Craniofacial dystonia (HP:0012179)1.69601238
132Visual hallucinations (HP:0002367)1.69465815
133Mutism (HP:0002300)1.69448929
134Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.69366287
135Degeneration of the lateral corticospinal tracts (HP:0002314)1.69366287
136Pancreatic islet-cell hyperplasia (HP:0004510)1.69221330
137Methylmalonic acidemia (HP:0002912)1.68568973
138Focal motor seizures (HP:0011153)1.67952399
139Type I transferrin isoform profile (HP:0003642)1.67769883
140Medulloblastoma (HP:0002885)1.67703771
141Respiratory failure (HP:0002878)1.67676617
142Skin nodule (HP:0200036)1.64763397
143Deep venous thrombosis (HP:0002625)1.64441250
144Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.64368348
145Abnormality of alanine metabolism (HP:0010916)1.64368348
146Hyperalaninemia (HP:0003348)1.64368348
147Epiphyseal dysplasia (HP:0002656)1.63057062
148Neoplasm of the peripheral nervous system (HP:0100007)1.62960138
149Nemaline bodies (HP:0003798)1.62443017
150Intrahepatic cholestasis (HP:0001406)1.62203939
151Vertebral compression fractures (HP:0002953)1.60997764
152Stridor (HP:0010307)1.60513744
153Cholecystitis (HP:0001082)1.60393880
154Abnormal gallbladder physiology (HP:0012438)1.60393880
155Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.60356729
156Limb dystonia (HP:0002451)1.59594743
157Hyperlipoproteinemia (HP:0010980)1.59563000
158Ketosis (HP:0001946)1.59497719
159Irregular epiphyses (HP:0010582)1.59039198
160Conjugated hyperbilirubinemia (HP:0002908)1.57738769
161Irritability (HP:0000737)1.57606096
162Delayed epiphyseal ossification (HP:0002663)1.56571938
163Focal dystonia (HP:0004373)1.56431384
164Soft skin (HP:0000977)1.55848196
165Cholelithiasis (HP:0001081)1.54918295
166Abnormal pupillary function (HP:0007686)1.54863431
167Opisthotonus (HP:0002179)1.54183967
168Curly hair (HP:0002212)1.53486960
169CNS demyelination (HP:0007305)1.53230553
170Abnormality of dentin (HP:0010299)1.52925632
171Hypoplasia of the odontoid process (HP:0003311)1.52407284
172Anxiety (HP:0000739)1.52312106
173Epileptic encephalopathy (HP:0200134)1.52052139
174Round ear (HP:0100830)1.51743013
175Restlessness (HP:0000711)1.50480242
176Hoarse voice (HP:0001609)1.50394576
177Delusions (HP:0000746)1.48755492
178Abnormality of purine metabolism (HP:0004352)1.47543133

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.30538529
2LIMK13.30253771
3MAP3K123.23669911
4MAPKAPK53.16253125
5CASK3.11065480
6MAP4K22.48878047
7STK392.38879335
8BCR2.11525441
9OXSR12.08642964
10EIF2AK31.96599257
11WNK41.94518265
12CDK191.86298498
13FER1.84485518
14PINK11.77708383
15BCKDK1.76773477
16NTRK11.75578859
17MST41.65343643
18TNIK1.64190426
19MKNK21.63992976
20PBK1.63685995
21ARAF1.58067246
22MARK11.56563460
23ERBB31.56315603
24MKNK11.56294067
25PLK21.54956694
26MAP2K71.53895689
27PAK31.48536109
28NUAK11.48532613
29MAP2K41.47466603
30TESK11.44586210
31SIK31.42181940
32MYLK1.41255067
33MINK11.39690300
34MAPKAPK31.37915908
35LATS21.35361828
36SRPK11.32552478
37PLK31.31360270
38STK38L1.29030361
39DYRK21.28258867
40DDR21.27322432
41GRK51.19193246
42GRK11.18945550
43MAP3K41.17837416
44BMPR1B1.14293386
45ERBB41.09827663
46CDK141.09198636
47WNK31.07330183
48AKT31.05220759
49MET1.01926818
50STK161.00657524
51CAMKK20.99634071
52GRK70.98640798
53NME10.98252800
54WEE10.97368293
55ERN10.94761806
56PIM20.92313358
57PDK30.92300428
58PDK40.92300428
59MUSK0.91887747
60PRKCE0.90985372
61BRSK20.90019541
62MAP2K10.89346993
63ADRBK20.89214046
64CSNK1G30.89005118
65PDK20.88666532
66CAMK2A0.85259003
67MAPK130.83658336
68MOS0.81573874
69CSNK1G20.79526099
70CAMK2D0.79178198
71EPHA30.78422555
72STK240.78174635
73PRKCG0.77659230
74EPHA40.77373303
75PNCK0.77294038
76DAPK20.75833885
77FRK0.75039727
78MAP3K20.74182241
79KDR0.73975953
80PIK3CG0.73895468
81CAMK2G0.73632878
82CAMK2B0.73607037
83SGK4940.73214572
84SGK2230.73214572
85CDK180.71640693
86EPHB10.71532313
87YES10.71050392
88RPS6KA40.68934141
89TSSK60.68267633
90TGFBR20.68220655
91NTRK30.67213954
92CDK150.66482392
93PIK3CA0.63601885
94DYRK30.63482023
95FGFR20.61151840
96ZAK0.60944519
97KSR10.60605759
98CDK50.60433100
99CCNB10.60193516
100ABL20.59791571
101ADRBK10.59538091
102TGFBR10.58892827
103INSRR0.58769432
104PHKG10.57411584
105PHKG20.57411584
106KSR20.56961122
107PDGFRA0.56664442
108TIE10.55905374
109CDK11A0.55686893
110BUB10.54929889
111UHMK10.54565717
112MAPK150.54230654
113ROCK20.53743079
114NEK60.52545945
115SCYL20.52358996
116CSNK1G10.52150226
117MST1R0.50423428
118NEK10.50375914
119PLK40.48374941
120MAP3K50.47907631
121PAK60.47482618
122CDK80.47231184
123EIF2AK10.46670394
124VRK10.46622940
125PTK20.46575905
126MAP3K110.45004764
127MAP3K30.44978820
128ACVR1B0.44599595
129OBSCN0.44261636
130CSNK1A1L0.44027521
131EIF2AK20.43566280
132ROCK10.42854630
133PLK10.42234120
134CSNK1A10.38708147
135FGFR10.36655838
136NTRK20.33479804
137LATS10.32697237
138STK30.32668700
139PKN10.32249954
140PRKACB0.31528949
141EGFR0.31417129
142PRKG10.30580879

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.03397309
2Protein export_Homo sapiens_hsa030602.77266142
3Fatty acid elongation_Homo sapiens_hsa000622.67810630
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.65069133
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.56087894
6Oxidative phosphorylation_Homo sapiens_hsa001902.51634575
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.33213395
8Vibrio cholerae infection_Homo sapiens_hsa051102.05809593
9Sulfur metabolism_Homo sapiens_hsa009202.01966310
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98106897
11Steroid biosynthesis_Homo sapiens_hsa001001.97705257
12Parkinsons disease_Homo sapiens_hsa050121.96649144
13Collecting duct acid secretion_Homo sapiens_hsa049661.96347448
14Butanoate metabolism_Homo sapiens_hsa006501.95601069
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.95433767
16Propanoate metabolism_Homo sapiens_hsa006401.95410817
17Pyruvate metabolism_Homo sapiens_hsa006201.92787832
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.92486757
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87968975
20Caffeine metabolism_Homo sapiens_hsa002321.87255917
21Proteasome_Homo sapiens_hsa030501.68825326
22Synaptic vesicle cycle_Homo sapiens_hsa047211.66165764
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.63081302
24Fatty acid metabolism_Homo sapiens_hsa012121.60126783
25Basal transcription factors_Homo sapiens_hsa030221.52777265
26Alzheimers disease_Homo sapiens_hsa050101.46628533
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46218426
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.44783982
29Fatty acid degradation_Homo sapiens_hsa000711.39942340
30Phototransduction_Homo sapiens_hsa047441.37468145
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36909211
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36372336
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30640335
34Peroxisome_Homo sapiens_hsa041461.29338397
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28462229
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26603525
37Folate biosynthesis_Homo sapiens_hsa007901.24016104
38Circadian rhythm_Homo sapiens_hsa047101.22688155
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.20680433
40Histidine metabolism_Homo sapiens_hsa003401.20499932
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.17028484
42Regulation of autophagy_Homo sapiens_hsa041401.14310087
43Tryptophan metabolism_Homo sapiens_hsa003801.14022226
44Selenocompound metabolism_Homo sapiens_hsa004501.12682038
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12231170
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10753317
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07633639
48Nitrogen metabolism_Homo sapiens_hsa009101.05445231
49RNA degradation_Homo sapiens_hsa030181.04780123
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01788300
51Fatty acid biosynthesis_Homo sapiens_hsa000611.01194160
52GABAergic synapse_Homo sapiens_hsa047270.98743935
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98605614
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95947668
55Oocyte meiosis_Homo sapiens_hsa041140.95891507
56Carbon metabolism_Homo sapiens_hsa012000.95514064
57Non-homologous end-joining_Homo sapiens_hsa034500.94903556
58Huntingtons disease_Homo sapiens_hsa050160.94061708
59Phagosome_Homo sapiens_hsa041450.93193927
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92933194
61Phenylalanine metabolism_Homo sapiens_hsa003600.92830981
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92796677
63Taste transduction_Homo sapiens_hsa047420.90952929
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88938368
65Glutamatergic synapse_Homo sapiens_hsa047240.84761526
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81801602
67Morphine addiction_Homo sapiens_hsa050320.81190877
68Arginine biosynthesis_Homo sapiens_hsa002200.80717792
69Arginine and proline metabolism_Homo sapiens_hsa003300.79007890
70Serotonergic synapse_Homo sapiens_hsa047260.77252995
71RNA polymerase_Homo sapiens_hsa030200.75923578
72Ether lipid metabolism_Homo sapiens_hsa005650.75372465
73Glutathione metabolism_Homo sapiens_hsa004800.73273305
74Chemical carcinogenesis_Homo sapiens_hsa052040.73236355
75Tyrosine metabolism_Homo sapiens_hsa003500.72776014
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72688787
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72614442
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72167560
79Sphingolipid metabolism_Homo sapiens_hsa006000.71140489
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70283665
81Fanconi anemia pathway_Homo sapiens_hsa034600.69917611
82beta-Alanine metabolism_Homo sapiens_hsa004100.68433830
83Amphetamine addiction_Homo sapiens_hsa050310.64666819
84Lysosome_Homo sapiens_hsa041420.64182157
85Cardiac muscle contraction_Homo sapiens_hsa042600.64130941
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.64039680
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63485498
88Galactose metabolism_Homo sapiens_hsa000520.61573476
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59507430
90Metabolic pathways_Homo sapiens_hsa011000.58871081
91Long-term depression_Homo sapiens_hsa047300.57492650
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57219247
93Rheumatoid arthritis_Homo sapiens_hsa053230.55818302
94PPAR signaling pathway_Homo sapiens_hsa033200.55493773
95Renin secretion_Homo sapiens_hsa049240.55182033
96RNA transport_Homo sapiens_hsa030130.54689461
97Linoleic acid metabolism_Homo sapiens_hsa005910.53507416
98ECM-receptor interaction_Homo sapiens_hsa045120.51829894
99Biosynthesis of amino acids_Homo sapiens_hsa012300.50866590
100Complement and coagulation cascades_Homo sapiens_hsa046100.50570912
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.50282999
102TGF-beta signaling pathway_Homo sapiens_hsa043500.49731322
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49614772
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49362162
105Dopaminergic synapse_Homo sapiens_hsa047280.49113922
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49040495
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48106934
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47533265
109Ovarian steroidogenesis_Homo sapiens_hsa049130.46977403
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46824742
111Olfactory transduction_Homo sapiens_hsa047400.44435552
112Vitamin B6 metabolism_Homo sapiens_hsa007500.42263229
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.41426453
114Arachidonic acid metabolism_Homo sapiens_hsa005900.41407883
115N-Glycan biosynthesis_Homo sapiens_hsa005100.40954278
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40908372
117Endocytosis_Homo sapiens_hsa041440.40199759
118Insulin secretion_Homo sapiens_hsa049110.39961971
119Hedgehog signaling pathway_Homo sapiens_hsa043400.39796713
120p53 signaling pathway_Homo sapiens_hsa041150.38121969
121Hippo signaling pathway_Homo sapiens_hsa043900.37746247
122Sulfur relay system_Homo sapiens_hsa041220.36500773
123Axon guidance_Homo sapiens_hsa043600.34973970
124Gap junction_Homo sapiens_hsa045400.32570769
125Retinol metabolism_Homo sapiens_hsa008300.32354737
126Nicotine addiction_Homo sapiens_hsa050330.31020786
127Circadian entrainment_Homo sapiens_hsa047130.30970143
128Bile secretion_Homo sapiens_hsa049760.30215839
129Cocaine addiction_Homo sapiens_hsa050300.30027229
130Prion diseases_Homo sapiens_hsa050200.27282779
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26020197

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