R3HCC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1formation of translation preinitiation complex (GO:0001731)4.87961016
2iron-sulfur cluster assembly (GO:0016226)4.75990940
3metallo-sulfur cluster assembly (GO:0031163)4.75990940
4maturation of SSU-rRNA (GO:0030490)4.54830637
5deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.27465713
6heterochromatin organization (GO:0070828)4.26229136
7positive regulation of mitochondrial fission (GO:0090141)4.20350965
8DNA deamination (GO:0045006)4.20224147
9base-excision repair, AP site formation (GO:0006285)4.10705252
10DNA unwinding involved in DNA replication (GO:0006268)4.09990153
11nucleobase biosynthetic process (GO:0046112)4.02942126
12ribosomal large subunit biogenesis (GO:0042273)4.02867222
13peptidyl-arginine omega-N-methylation (GO:0035247)4.02082909
14DNA strand elongation involved in DNA replication (GO:0006271)3.94792386
15viral transcription (GO:0019083)3.92730058
16translational initiation (GO:0006413)3.86653971
17protein targeting to mitochondrion (GO:0006626)3.86344281
18negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.85398729
19purine nucleobase biosynthetic process (GO:0009113)3.84975124
20translational termination (GO:0006415)3.84413089
21translational elongation (GO:0006414)3.72273517
22DNA strand elongation (GO:0022616)3.71700146
23establishment of protein localization to mitochondrion (GO:0072655)3.66639553
24ribosomal small subunit assembly (GO:0000028)3.65527309
25ribosome biogenesis (GO:0042254)3.63899715
26spliceosomal snRNP assembly (GO:0000387)3.62893460
27positive regulation of protein sumoylation (GO:0033235)3.61362506
28pyrimidine nucleobase catabolic process (GO:0006208)3.60285677
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.57524877
30ribosome assembly (GO:0042255)3.55787787
31regulation of mitochondrial translation (GO:0070129)3.54716204
32histone arginine methylation (GO:0034969)3.53469123
33pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.52965661
34ribonucleoprotein complex biogenesis (GO:0022613)3.50010531
35protein localization to mitochondrion (GO:0070585)3.49889274
36protein localization to kinetochore (GO:0034501)3.47227677
37protein-cofactor linkage (GO:0018065)3.44725841
38peptidyl-arginine N-methylation (GO:0035246)3.44590165
39peptidyl-arginine methylation (GO:0018216)3.44590165
40protein insertion into membrane (GO:0051205)3.44403456
41mitochondrial fusion (GO:0008053)3.41210524
42mitotic nuclear envelope disassembly (GO:0007077)3.40972933
43DNA replication initiation (GO:0006270)3.40658070
44protein maturation by protein folding (GO:0022417)3.39389646
45respiratory chain complex IV assembly (GO:0008535)3.38654824
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.36548909
47termination of RNA polymerase III transcription (GO:0006386)3.36548909
48nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.36069676
49protein complex biogenesis (GO:0070271)3.35182099
50oxidative phosphorylation (GO:0006119)3.35029098
51negative regulation of RNA splicing (GO:0033119)3.34664218
52DNA replication-dependent nucleosome organization (GO:0034723)3.34557808
53DNA replication-dependent nucleosome assembly (GO:0006335)3.34557808
54DNA damage response, detection of DNA damage (GO:0042769)3.32619416
55negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32262922
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.32107413
57mitochondrial respiratory chain complex I assembly (GO:0032981)3.32107413
58NADH dehydrogenase complex assembly (GO:0010257)3.32107413
59de novo posttranslational protein folding (GO:0051084)3.30696401
60energy coupled proton transport, down electrochemical gradient (GO:0015985)3.27454566
61ATP synthesis coupled proton transport (GO:0015986)3.27454566
62pyrimidine nucleotide catabolic process (GO:0006244)3.27123336
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.25800966
64telomere maintenance via semi-conservative replication (GO:0032201)3.25686737
65mitochondrial respiratory chain complex assembly (GO:0033108)3.25387223
66GMP metabolic process (GO:0046037)3.23062228
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.21970709
68nuclear envelope disassembly (GO:0051081)3.20358674
69membrane disassembly (GO:0030397)3.20358674
70positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.19884986
71de novo protein folding (GO:0006458)3.19708852
72rRNA processing (GO:0006364)3.17431039
73establishment of protein localization to mitochondrial membrane (GO:0090151)3.17073059
74DNA replication checkpoint (GO:0000076)3.16592854
75regulation of cellular amino acid metabolic process (GO:0006521)3.16137252
76cullin deneddylation (GO:0010388)3.16060241
77mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.16006146
78SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.15439652
79negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.13749241
80negative regulation of ligase activity (GO:0051352)3.13749241
81ubiquinone biosynthetic process (GO:0006744)3.13243599
82guanosine-containing compound biosynthetic process (GO:1901070)3.11723902
83cellular protein complex disassembly (GO:0043624)3.11421276
84proteasome assembly (GO:0043248)3.09820172
85histone H2A acetylation (GO:0043968)3.09677928
86maturation of 5.8S rRNA (GO:0000460)3.09337506
87deoxyribonucleotide catabolic process (GO:0009264)3.08329404
88folic acid-containing compound biosynthetic process (GO:0009396)3.07004080
89rRNA metabolic process (GO:0016072)3.06499190
90protein deneddylation (GO:0000338)3.06179049
91protein targeting to ER (GO:0045047)3.04091273
92folic acid metabolic process (GO:0046655)3.03596077
93protein localization to chromosome, centromeric region (GO:0071459)3.03217851
94ribosomal small subunit biogenesis (GO:0042274)3.02809526
95cotranslational protein targeting to membrane (GO:0006613)3.02641714
96negative regulation of mRNA processing (GO:0050686)3.02441458
97protein complex disassembly (GO:0043241)3.01861844
98negative regulation of chromosome segregation (GO:0051985)3.01713426
99viral life cycle (GO:0019058)3.00923373
100regulation of mitochondrial fission (GO:0090140)2.99822889
101peptidyl-histidine modification (GO:0018202)2.99638524
102mitotic metaphase plate congression (GO:0007080)2.97948020
103regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.97692345
104mRNA splicing, via spliceosome (GO:0000398)2.97211987
105RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.97211987
106respiratory electron transport chain (GO:0022904)2.97208231
107energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.97199870
108ATP hydrolysis coupled proton transport (GO:0015991)2.97199870
109negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96608258
110negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96608258
111negative regulation of sister chromatid segregation (GO:0033046)2.96608258
112negative regulation of mitotic sister chromatid separation (GO:2000816)2.96608258
113viral protein processing (GO:0019082)2.95804941
114translation (GO:0006412)2.95764068
115positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.95667443
116alternative mRNA splicing, via spliceosome (GO:0000380)2.95366824
117mitotic spindle assembly checkpoint (GO:0007094)2.95318426
118RNA splicing, via transesterification reactions (GO:0000375)2.94978737
119mitochondrial RNA metabolic process (GO:0000959)2.94557999
120spliceosomal complex assembly (GO:0000245)2.94340699
121NADH metabolic process (GO:0006734)2.93768789
122purine deoxyribonucleotide catabolic process (GO:0009155)2.91418328
123regulation of translational termination (GO:0006449)2.91398330
124chaperone-mediated protein transport (GO:0072321)2.90849327
125pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.90829619
126chaperone-mediated protein complex assembly (GO:0051131)2.90722393
127protein localization to endoplasmic reticulum (GO:0070972)2.90636244
128regulation of protein sumoylation (GO:0033233)2.90390564
129electron transport chain (GO:0022900)2.90081083
130nuclear pore organization (GO:0006999)2.89314394
131deoxyribose phosphate catabolic process (GO:0046386)2.89224481
132ubiquinone metabolic process (GO:0006743)2.88472067
133establishment of protein localization to endoplasmic reticulum (GO:0072599)2.88417890
134spindle assembly checkpoint (GO:0071173)2.88273245
135ncRNA 3-end processing (GO:0043628)2.87419551
136mitochondrial DNA metabolic process (GO:0032042)2.87400564
137macromolecular complex disassembly (GO:0032984)2.87225281
138cytochrome complex assembly (GO:0017004)2.86493422
139negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.85352378
140negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.84777794
141establishment of mitochondrion localization (GO:0051654)2.84680152
142regulation of spindle organization (GO:0090224)2.84514992
143IMP biosynthetic process (GO:0006188)2.83263989
144paraxial mesoderm development (GO:0048339)2.82317841
1457-methylguanosine mRNA capping (GO:0006370)2.81776676
146cellular component biogenesis (GO:0044085)2.80198277
147DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.80095902
148gluconeogenesis (GO:0006094)2.79996879
149regulation of ubiquitin-protein transferase activity (GO:0051438)2.79703458
150amino acid activation (GO:0043038)2.78442228
151tRNA aminoacylation (GO:0043039)2.78442228
152tRNA aminoacylation for protein translation (GO:0006418)2.77966194
153pseudouridine synthesis (GO:0001522)2.76888081
154nuclear envelope organization (GO:0006998)2.75638325
155positive regulation of ligase activity (GO:0051351)2.74862592
156UV protection (GO:0009650)2.73637203
157L-serine metabolic process (GO:0006563)2.73536488
158mitotic spindle checkpoint (GO:0071174)2.73203321
159spliceosomal tri-snRNP complex assembly (GO:0000244)2.72970282
160tricarboxylic acid cycle (GO:0006099)2.72572228
161RNA capping (GO:0036260)2.72156175
1627-methylguanosine RNA capping (GO:0009452)2.72156175
163signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.71393658
164intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.71393658
165negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.70885070
166regulation of translational fidelity (GO:0006450)2.70462998
167telomere maintenance via recombination (GO:0000722)2.69231543
168establishment of viral latency (GO:0019043)2.68916995
169establishment of integrated proviral latency (GO:0075713)2.67944501
170inner mitochondrial membrane organization (GO:0007007)2.67127625
171signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.67100905
172signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.67100905
173signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.67100905
1742-deoxyribonucleotide metabolic process (GO:0009394)2.66996195
175negative regulation of mRNA metabolic process (GO:1903312)2.66591541
176negative regulation of translational initiation (GO:0045947)2.66479583
177nuclear-transcribed mRNA catabolic process (GO:0000956)2.66265569

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.44054380
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.24491133
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.10959247
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.12026836
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.02763123
6ETS1_20019798_ChIP-Seq_JURKAT_Human2.98816373
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.91086778
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.88070158
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.87866491
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77913300
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.70327958
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.64710150
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.63672189
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55917701
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.54371270
16XRN2_22483619_ChIP-Seq_HELA_Human2.52853209
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.49543598
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.49255791
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48694194
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28308989
21GABP_19822575_ChIP-Seq_HepG2_Human2.03325054
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.03002748
23MYC_22102868_ChIP-Seq_BL_Human1.99773046
24E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99497137
25CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.90459379
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90231902
27TTF2_22483619_ChIP-Seq_HELA_Human1.87124363
28VDR_23849224_ChIP-Seq_CD4+_Human1.85632777
29CIITA_25753668_ChIP-Seq_RAJI_Human1.85096250
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82302210
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81968811
32DCP1A_22483619_ChIP-Seq_HELA_Human1.81564688
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80861373
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79038106
35ZFX_18555785_ChIP-Seq_MESCs_Mouse1.77924221
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76603284
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.75935208
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74226080
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74090280
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.73955764
41FOXP3_21729870_ChIP-Seq_TREG_Human1.71904382
42AR_21909140_ChIP-Seq_LNCAP_Human1.70173047
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64292580
44CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.62063680
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61847182
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59955379
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57976236
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55054148
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52899128
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52849762
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.52673960
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52334802
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52197144
54KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.47478257
55KDM5A_27292631_Chip-Seq_BREAST_Human1.46286128
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45241946
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43810676
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41037614
59ZNF263_19887448_ChIP-Seq_K562_Human1.40263815
60CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40221522
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.39605630
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37340347
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.36358291
64KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.36177240
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35751997
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35730869
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32076937
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.31004278
69EGR1_19374776_ChIP-ChIP_THP-1_Human1.28969653
70CTCF_18555785_ChIP-Seq_MESCs_Mouse1.28326227
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23045525
72CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22324116
73ELF1_20517297_ChIP-Seq_JURKAT_Human1.22128058
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22024721
75TFEB_21752829_ChIP-Seq_HELA_Human1.20333654
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20276531
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19901536
78CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.18973869
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18700942
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17508725
81NANOG_21062744_ChIP-ChIP_HESCs_Human1.17448571
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17125145
83SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16852010
84VDR_21846776_ChIP-Seq_THP-1_Human1.14572467
85P68_20966046_ChIP-Seq_HELA_Human1.14187163
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13631632
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11483443
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10885913
89TBX5_21415370_ChIP-Seq_HL-1_Mouse1.10780640
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10626036
91* FOXP1_21924763_ChIP-Seq_HESCs_Human1.09214028
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09189906
93SRF_21415370_ChIP-Seq_HL-1_Mouse1.08559970
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08300708
95BCL6_27268052_Chip-Seq_Bcells_Human1.08173012
96MYC_18940864_ChIP-ChIP_HL60_Human1.07499107
97SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06727535
98YY1_22570637_ChIP-Seq_MALME-3M_Human1.05641108
99SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05442025
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04956608
101SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04796031
102OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03582364
103E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02230383
104PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01909293
105SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01507784
106CTCF_26484167_Chip-Seq_Bcells_Mouse1.00377849
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99013408
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96963690
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96231054
110ELK1_19687146_ChIP-ChIP_HELA_Human0.96117419
111* LXR_22292898_ChIP-Seq_THP-1_Human0.95869430
112ELK3_25401928_ChIP-Seq_HUVEC_Human0.95361746
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94554475
114IRF1_19129219_ChIP-ChIP_H3396_Human0.94380074
115TET1_21451524_ChIP-Seq_MESCs_Mouse0.94126820
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93732624
117FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93178945
118TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92791711
119ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92708044
120ELK1_22589737_ChIP-Seq_MCF10A_Human0.92373123
121ATF3_27146783_Chip-Seq_COLON_Human0.92184443
122NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92166828
123SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91706280
124TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91139107
125* PHF8_20622854_ChIP-Seq_HELA_Human0.89535900
126SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.87742168
127* RARB_24833708_ChIP-Seq_LIVER_Mouse0.86922057

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.47028633
2MP0004957_abnormal_blastocyst_morpholog3.66425834
3MP0003111_abnormal_nucleus_morphology3.62191528
4MP0010030_abnormal_orbit_morphology3.60250260
5MP0003077_abnormal_cell_cycle3.21868641
6MP0001529_abnormal_vocalization3.15554580
7MP0010094_abnormal_chromosome_stability3.06530376
8MP0008789_abnormal_olfactory_epithelium3.02772136
9MP0006292_abnormal_olfactory_placode2.87193187
10MP0003123_paternal_imprinting2.78581158
11MP0005394_taste/olfaction_phenotype2.75617657
12MP0005499_abnormal_olfactory_system2.75617657
13MP0000372_irregular_coat_pigmentation2.69451507
14MP0001730_embryonic_growth_arrest2.55882013
15MP0008260_abnormal_autophagy2.55633656
16MP0002822_catalepsy2.54909558
17MP0008932_abnormal_embryonic_tissue2.51361905
18MP0002102_abnormal_ear_morphology2.45297465
19MP0001984_abnormal_olfaction2.30580229
20MP0008007_abnormal_cellular_replicative2.27689183
21MP0003186_abnormal_redox_activity2.20982096
22MP0000537_abnormal_urethra_morphology2.17882718
23MP0002653_abnormal_ependyma_morphology2.17371909
24MP0003705_abnormal_hypodermis_morpholog2.11929882
25MP0006276_abnormal_autonomic_nervous2.09135366
26MP0004859_abnormal_synaptic_plasticity2.07043619
27MP0008058_abnormal_DNA_repair1.96118159
28MP0001697_abnormal_embryo_size1.93901062
29MP0000350_abnormal_cell_proliferation1.92537519
30MP0005380_embryogenesis_phenotype1.90465758
31MP0001672_abnormal_embryogenesis/_devel1.90465758
32MP0003806_abnormal_nucleotide_metabolis1.87550850
33MP0003984_embryonic_growth_retardation1.82989404
34MP0003315_abnormal_perineum_morphology1.80748207
35MP0002088_abnormal_embryonic_growth/wei1.79263791
36MP0002080_prenatal_lethality1.76132703
37MP0002085_abnormal_embryonic_tissue1.74723643
38MP0010352_gastrointestinal_tract_polyps1.73312339
39MP0000750_abnormal_muscle_regeneration1.71995120
40MP0002084_abnormal_developmental_patter1.67947867
41MP0003567_abnormal_fetal_cardiomyocyte1.67802977
42MP0008995_early_reproductive_senescence1.66163313
43MP0004084_abnormal_cardiac_muscle1.64864895
44MP0009053_abnormal_anal_canal1.62886507
45MP0003119_abnormal_digestive_system1.59530800
46MP0002396_abnormal_hematopoietic_system1.58910612
47MP0001905_abnormal_dopamine_level1.55687813
48MP0004270_analgesia1.55180212
49MP0004145_abnormal_muscle_electrophysio1.54822559
50MP0004197_abnormal_fetal_growth/weight/1.50782335
51MP0000749_muscle_degeneration1.48313070
52MP0008057_abnormal_DNA_replication1.46591053
53MP0001764_abnormal_homeostasis1.43307832
54MP0004233_abnormal_muscle_weight1.39293689
55MP0003942_abnormal_urinary_system1.39240670
56MP0002282_abnormal_trachea_morphology1.37916984
57MP0003011_delayed_dark_adaptation1.37848500
58MP0000428_abnormal_craniofacial_morphol1.35482224
59MP0002086_abnormal_extraembryonic_tissu1.35233972
60MP0002735_abnormal_chemical_nociception1.34807525
61MP0003635_abnormal_synaptic_transmissio1.32457123
62MP0001502_abnormal_circadian_rhythm1.31469005
63MP0005075_abnormal_melanosome_morpholog1.31214005
64MP0002638_abnormal_pupillary_reflex1.30502308
65MP0003122_maternal_imprinting1.30212781
66MP0004811_abnormal_neuron_physiology1.29427678
67MP0003786_premature_aging1.27523288
68MP0001968_abnormal_touch/_nociception1.26717222
69MP0003121_genomic_imprinting1.26655281
70MP0002272_abnormal_nervous_system1.26631857
71MP0003115_abnormal_respiratory_system1.25627614
72MP0002736_abnormal_nociception_after1.25267811
73MP0000358_abnormal_cell_content/1.25235073
74MP0003221_abnormal_cardiomyocyte_apopto1.24997022
75MP0002269_muscular_atrophy1.21032496
76MP0001849_ear_inflammation1.20805888
77MP0008438_abnormal_cutaneous_collagen1.18933469
78MP0000778_abnormal_nervous_system1.18613418
79MP0009046_muscle_twitch1.17635503
80MP0009697_abnormal_copulation1.17079216
81MP0000313_abnormal_cell_death1.16528849
82MP0005646_abnormal_pituitary_gland1.16336457
83MP0002063_abnormal_learning/memory/cond1.15944814
84MP0002572_abnormal_emotion/affect_behav1.15834222
85MP0001293_anophthalmia1.15342180
86MP0006054_spinal_hemorrhage1.15047953
87MP0000049_abnormal_middle_ear1.13680602
88MP0005623_abnormal_meninges_morphology1.13367931
89MP0000534_abnormal_ureter_morphology1.12220469
90MP0009672_abnormal_birth_weight1.11435765
91MP0003718_maternal_effect1.10867419
92MP0008877_abnormal_DNA_methylation1.10184543
93MP0002932_abnormal_joint_morphology1.09384126
94MP0000733_abnormal_muscle_development1.09242177
95MP0004808_abnormal_hematopoietic_stem1.08574507
96MP0006035_abnormal_mitochondrial_morpho1.08381183
97MP0003879_abnormal_hair_cell1.07659881
98MP0002064_seizures1.06324991
99MP0002111_abnormal_tail_morphology1.01429125
100MP0002210_abnormal_sex_determination1.01350213
101MP0000751_myopathy1.00227987
102MP0002249_abnormal_larynx_morphology0.99552438
103MP0009745_abnormal_behavioral_response0.99517353
104MP0005058_abnormal_lysosome_morphology0.98988183
105MP0001145_abnormal_male_reproductive0.98147151
106MP0005503_abnormal_tendon_morphology0.98097673
107MP0000681_abnormal_thyroid_gland0.96673746
108MP0010630_abnormal_cardiac_muscle0.96394932
109MP0005410_abnormal_fertilization0.96387227
110MP0003878_abnormal_ear_physiology0.96247123
111MP0005377_hearing/vestibular/ear_phenot0.96247123
112MP0001929_abnormal_gametogenesis0.94125357
113MP0002019_abnormal_tumor_incidence0.93599310
114MP0004133_heterotaxia0.92449014
115MP0000955_abnormal_spinal_cord0.92409500
116MP0000490_abnormal_crypts_of0.91607830
117MP0002160_abnormal_reproductive_system0.91489289
118MP0005330_cardiomyopathy0.90958936
119MP0005187_abnormal_penis_morphology0.90007784
120MP0002734_abnormal_mechanical_nocicepti0.89729022
121MP0003937_abnormal_limbs/digits/tail_de0.89468900
122MP0001270_distended_abdomen0.89026743
123MP0002882_abnormal_neuron_morphology0.88625257
124MP0005076_abnormal_cell_differentiation0.88488801
125MP0002938_white_spotting0.87157529
126MP0003935_abnormal_craniofacial_develop0.87138918
127MP0004858_abnormal_nervous_system0.86831872
128MP0001986_abnormal_taste_sensitivity0.86561399
129MP0003880_abnormal_central_pattern0.86075793
130MP0002092_abnormal_eye_morphology0.84360801
131MP0002277_abnormal_respiratory_mucosa0.82893235
132MP0008770_decreased_survivor_rate0.82409999
133MP0000747_muscle_weakness0.82318265
134MP0002557_abnormal_social/conspecific_i0.82101273
135MP0003283_abnormal_digestive_organ0.81806890
136MP0002067_abnormal_sensory_capabilities0.81714510
137MP0003861_abnormal_nervous_system0.81415421
138MP0002089_abnormal_postnatal_growth/wei0.81086397
139MP0004087_abnormal_muscle_fiber0.81072320
140MP0003279_aneurysm0.80580441
141MP0001881_abnormal_mammary_gland0.80343255
142MP0002066_abnormal_motor_capabilities/c0.79547093
143MP0005084_abnormal_gallbladder_morpholo0.79422854
144MP0005023_abnormal_wound_healing0.78700080
145MP0002752_abnormal_somatic_nervous0.78529642
146MP0000653_abnormal_sex_gland0.77130164
147MP0004742_abnormal_vestibular_system0.77123694
148MP0000759_abnormal_skeletal_muscle0.76823111
149MP0003385_abnormal_body_wall0.76169829
150MP0000266_abnormal_heart_morphology0.75824867
151MP0000631_abnormal_neuroendocrine_gland0.74824889
152MP0002069_abnormal_eating/drinking_beha0.74586467
153MP0006036_abnormal_mitochondrial_physio0.74507461
154MP0003755_abnormal_palate_morphology0.74067369
155MP0004510_myositis0.73937792
156MP0002234_abnormal_pharynx_morphology0.73603397
157MP0003698_abnormal_male_reproductive0.73500191
158MP0001545_abnormal_hematopoietic_system0.73301449
159MP0005397_hematopoietic_system_phenotyp0.73301449
160MP0005423_abnormal_somatic_nervous0.72278311
161MP0003787_abnormal_imprinting0.71682699
162MP0000015_abnormal_ear_pigmentation0.71629545
163MP0003938_abnormal_ear_development0.69657830
164MP0005171_absent_coat_pigmentation0.69113488
165MP0002184_abnormal_innervation0.68881944
166MP0002229_neurodegeneration0.67677712

Predicted human phenotypes

RankGene SetZ-score
1Abnormal mitochondria in muscle tissue (HP:0008316)4.49288223
2Acute necrotizing encephalopathy (HP:0006965)4.35222052
3Ependymoma (HP:0002888)4.10349033
4Abnormality of the anterior horn cell (HP:0006802)4.01282776
5Degeneration of anterior horn cells (HP:0002398)4.01282776
6Acute encephalopathy (HP:0006846)4.00231776
7Mitochondrial inheritance (HP:0001427)3.93309775
8Hepatocellular necrosis (HP:0001404)3.83489819
9Increased intramyocellular lipid droplets (HP:0012240)3.71901103
10Hepatic necrosis (HP:0002605)3.64038023
11Abnormality of glycolysis (HP:0004366)3.57652762
12Increased CSF lactate (HP:0002490)3.55230730
13Abnormal gallbladder physiology (HP:0012438)3.51784117
14Cholecystitis (HP:0001082)3.51784117
15Increased muscle lipid content (HP:0009058)3.44882387
16Selective tooth agenesis (HP:0001592)3.42920204
17Microvesicular hepatic steatosis (HP:0001414)3.40320557
18Myokymia (HP:0002411)3.38773235
19Progressive macrocephaly (HP:0004481)3.38752067
20Multiple enchondromatosis (HP:0005701)3.38279775
21Abnormality of the labia minora (HP:0012880)3.38186395
22Lactic acidosis (HP:0003128)3.29250051
23Increased serum pyruvate (HP:0003542)3.27321624
24Atrophy/Degeneration involving motor neurons (HP:0007373)3.18995213
25Patellar aplasia (HP:0006443)3.18139209
26Protrusio acetabuli (HP:0003179)3.14766650
27Abnormality of alanine metabolism (HP:0010916)3.14735756
28Hyperalaninemia (HP:0003348)3.14735756
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.14735756
30Aplasia/Hypoplasia of the patella (HP:0006498)3.13714643
31Cerebral edema (HP:0002181)3.10432555
32Increased serum lactate (HP:0002151)3.06211632
33Cerebral hypomyelination (HP:0006808)3.03701764
34Abnormality of cells of the erythroid lineage (HP:0012130)2.95513342
35Breast hypoplasia (HP:0003187)2.94549747
36Exercise intolerance (HP:0003546)2.90053598
37Ankle contracture (HP:0006466)2.87236753
38Abnormal number of erythroid precursors (HP:0012131)2.86854539
39Astrocytoma (HP:0009592)2.84516353
40Abnormality of the astrocytes (HP:0100707)2.84516353
41Carpal bone hypoplasia (HP:0001498)2.83241333
42Trismus (HP:0000211)2.77699768
433-Methylglutaconic aciduria (HP:0003535)2.69542757
44Abnormality of dicarboxylic acid metabolism (HP:0010995)2.68385823
45Dicarboxylic aciduria (HP:0003215)2.68385823
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.65872402
47Premature ovarian failure (HP:0008209)2.62159294
48Retinal dysplasia (HP:0007973)2.62091258
49Progressive muscle weakness (HP:0003323)2.61821982
50Birth length less than 3rd percentile (HP:0003561)2.59655430
51Medulloblastoma (HP:0002885)2.50185266
52Premature rupture of membranes (HP:0001788)2.48736026
53Microretrognathia (HP:0000308)2.48334796
54Angiofibromas (HP:0010615)2.46099490
55Adenoma sebaceum (HP:0009720)2.46099490
56Opisthotonus (HP:0002179)2.44184707
57Hyperthyroidism (HP:0000836)2.43027293
58Renal duplication (HP:0000075)2.42632428
59Colon cancer (HP:0003003)2.42366567
60Lipid accumulation in hepatocytes (HP:0006561)2.39628184
61Optic disc pallor (HP:0000543)2.39420124
62Difficulty climbing stairs (HP:0003551)2.38760081
63Gait imbalance (HP:0002141)2.38287163
64Respiratory failure (HP:0002878)2.37728208
65Secondary amenorrhea (HP:0000869)2.37640215
66Rough bone trabeculation (HP:0100670)2.36409008
67Reticulocytopenia (HP:0001896)2.33244811
68Glioma (HP:0009733)2.32286143
69Nephrogenic diabetes insipidus (HP:0009806)2.31435901
70CNS hypomyelination (HP:0003429)2.30217450
71Amyotrophic lateral sclerosis (HP:0007354)2.29256611
72Increased hepatocellular lipid droplets (HP:0006565)2.29060598
73Cholelithiasis (HP:0001081)2.25992034
74Hypoplasia of the pons (HP:0012110)2.25224801
75Broad distal phalanx of finger (HP:0009836)2.25215088
76Peripheral hypomyelination (HP:0007182)2.21749143
77Shoulder girdle muscle weakness (HP:0003547)2.21659347
78Renal Fanconi syndrome (HP:0001994)2.20283692
79Abnormality of the lower motor neuron (HP:0002366)2.19395143
80Abnormality of the umbilical cord (HP:0010881)2.19141821
81Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.18004272
82Ragged-red muscle fibers (HP:0003200)2.17916729
83Congenital primary aphakia (HP:0007707)2.16560942
84Decreased activity of mitochondrial respiratory chain (HP:0008972)2.13579006
85Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.13579006
86Shallow orbits (HP:0000586)2.13358236
87Atresia of the external auditory canal (HP:0000413)2.12134188
88Short 4th metacarpal (HP:0010044)2.10078645
89Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.10078645
90Abnormal protein N-linked glycosylation (HP:0012347)2.09683197
91Abnormal protein glycosylation (HP:0012346)2.09683197
92Abnormal glycosylation (HP:0012345)2.09683197
93Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09683197
94Neoplasm of the pancreas (HP:0002894)2.09560997
95Polyphagia (HP:0002591)2.09175598
96Optic nerve coloboma (HP:0000588)2.06638198
97Rimmed vacuoles (HP:0003805)2.03921870
98Methylmalonic aciduria (HP:0012120)2.02850938
99Oral leukoplakia (HP:0002745)2.02841286
100Medial flaring of the eyebrow (HP:0010747)2.01552628
101Impulsivity (HP:0100710)2.00659103
102Pelvic girdle muscle weakness (HP:0003749)2.00593738
103Delusions (HP:0000746)1.99875940
104Progressive microcephaly (HP:0000253)1.98762481
105Neoplasm of striated muscle (HP:0009728)1.98756118
106Increased nuchal translucency (HP:0010880)1.98241059
107Abnormality of the metopic suture (HP:0005556)1.97972925
108Leukodystrophy (HP:0002415)1.96905522
109Muscle fibrillation (HP:0010546)1.96738376
110Prominent metopic ridge (HP:0005487)1.96488951
111Abnormal gallbladder morphology (HP:0012437)1.96379795
112Abnormality of the calcaneus (HP:0008364)1.94342011
113Glossoptosis (HP:0000162)1.94084889
114Proximal placement of thumb (HP:0009623)1.93850219
115Macrocytic anemia (HP:0001972)1.91483304
116Missing ribs (HP:0000921)1.91165350
117Testicular atrophy (HP:0000029)1.90560092
118Slender long bone (HP:0003100)1.90459953
119Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.90410955
120Deviation of the thumb (HP:0009603)1.89962742
121Abnormality of the motor neurons (HP:0002450)1.89908502
122Abnormal neuron morphology (HP:0012757)1.89908502
123Abnormality of lateral ventricle (HP:0030047)1.89695830
124Impaired proprioception (HP:0010831)1.89482915
125Methylmalonic acidemia (HP:0002912)1.88768628
126Neoplasm of the heart (HP:0100544)1.87830546
127Lymphangioma (HP:0100764)1.87357741
128Amblyopia (HP:0000646)1.86445590
129Ankle clonus (HP:0011448)1.86299822
130Limb dystonia (HP:0002451)1.84338662
131Unsteady gait (HP:0002317)1.83400169
132Calcaneovalgus deformity (HP:0001848)1.82824166
133Type I transferrin isoform profile (HP:0003642)1.82343099
134Respiratory difficulties (HP:0002880)1.82166025
135Abnormality of the aortic arch (HP:0012303)1.81813300
136Wrist flexion contracture (HP:0001239)1.81650375
137Spinal muscular atrophy (HP:0007269)1.81223505
138Abnormality of the pons (HP:0007361)1.81159690
139Short 5th finger (HP:0009237)1.80551711
140CNS demyelination (HP:0007305)1.80525900
141Aplasia/hypoplasia of the humerus (HP:0006507)1.79896129
142Cortical dysplasia (HP:0002539)1.77788985
143Deformed tarsal bones (HP:0008119)1.77768544
144Hyperacusis (HP:0010780)1.77153510
145Lethargy (HP:0001254)1.76595835
146Postnatal microcephaly (HP:0005484)1.76553400
147Tongue fasciculations (HP:0001308)1.76084740
148Truncus arteriosus (HP:0001660)1.75692762
149Aplastic anemia (HP:0001915)1.74948067
150Abnormality of the gallbladder (HP:0005264)1.74836793
151Abnormality of the 4th metacarpal (HP:0010012)1.74184007
152Genu recurvatum (HP:0002816)1.74127804
153Sensorimotor neuropathy (HP:0007141)1.74053039
154Redundant skin (HP:0001582)1.73723871
155Short palpebral fissure (HP:0012745)1.72341278
156Rhabdomyolysis (HP:0003201)1.72279730
157X-linked dominant inheritance (HP:0001423)1.71928641
158Myoglobinuria (HP:0002913)1.71882452
159Cerebral palsy (HP:0100021)1.70993793
160Rhabdomyosarcoma (HP:0002859)1.70578089
161Gliosis (HP:0002171)1.69350275
162Abnormal cartilage morphology (HP:0002763)1.69251078
163Thyroid-stimulating hormone excess (HP:0002925)1.68146675
164Emotional lability (HP:0000712)1.67935607
165Basal cell carcinoma (HP:0002671)1.67436976
166Abnormal number of incisors (HP:0011064)1.67221475
167Aplasia/Hypoplasia of the sternum (HP:0006714)1.67059051
168Limb-girdle muscle atrophy (HP:0003797)1.65450945
169Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.64178650
17011 pairs of ribs (HP:0000878)1.63716943
171Abnormality of the hip-girdle musculature (HP:0001445)1.63127931
172Abnormality of the musculature of the pelvis (HP:0001469)1.63127931
173Abnormality of the distal phalanges of the toes (HP:0010182)1.61210216
174Hyperglycinemia (HP:0002154)1.60464227
175Pterygium (HP:0001059)1.59583984
176Facial cleft (HP:0002006)1.58820759
177Pallor (HP:0000980)1.58600587
178Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.58101951
179Absent thumb (HP:0009777)1.57614283
180Biconcave vertebral bodies (HP:0004586)1.55754004
181Death in infancy (HP:0001522)1.55366970

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.47880104
2WEE13.78695813
3EIF2AK13.19251449
4VRK22.73154090
5PKN22.69728310
6TRIB32.59521072
7TSSK62.57022524
8MAP4K22.48036761
9NEK12.41051288
10MAP2K72.33338985
11CDC72.33025928
12TESK22.32578663
13MAP3K102.23219176
14CSNK1G32.23173573
15NEK22.21867561
16ARAF2.15336570
17ACVR1B2.10721215
18NME22.02965564
19DYRK31.97213625
20MAP3K111.96421030
21LATS21.91397383
22CSNK1A1L1.80647613
23SRPK11.78517525
24TESK11.74087783
25EEF2K1.72254679
26PDK41.72217290
27PDK31.72217290
28CSNK1G21.71700547
29ABL21.61019146
30BRSK11.60692288
31CSNK1G11.59779736
32TGFBR11.59148156
33TRIM281.58450198
34STK161.54006097
35NTRK11.51525538
36BRSK21.48693976
37PLK11.46124375
38CDK191.40106493
39PAK41.38816444
40RPS6KA41.37992638
41BCR1.36264122
42DAPK11.34148646
43SIK21.32951886
44MARK11.31579966
45EPHA41.31483663
46ILK1.31216788
47TLK11.30445473
48EIF2AK31.26359077
49TTK1.25814512
50NME11.25206613
51PASK1.24682081
52CDK41.24276135
53FES1.21635950
54CDK71.21427636
55SCYL21.18116984
56MAP3K41.17564482
57AURKB1.15810612
58AURKA1.14717219
59ATR1.08233558
60RPS6KA51.07356402
61FLT31.06535895
62EPHA21.06011671
63PLK31.05850635
64PHKG11.04455023
65PHKG21.04455023
66MKNK11.03744276
67LRRK21.03499737
68ICK1.03412302
69PAK61.02380115
70MAP2K41.02219611
71CASK0.98816869
72CHEK20.97436303
73TTN0.94955149
74RPS6KB20.94627597
75MAP2K30.93862912
76BCKDK0.93434868
77MAP3K80.93271808
78PIM20.92536299
79RAF10.89572746
80PLK40.88234857
81CHEK10.87624995
82MTOR0.86656309
83STK38L0.83409209
84PDK20.83001769
85TAOK20.82310394
86PNCK0.81342126
87PAK10.79800274
88DYRK20.78266879
89MAP3K50.75493312
90EPHB20.73480599
91KDR0.72198462
92MAPK130.71963618
93CDK20.70670597
94PKN10.70493308
95CDK140.69047215
96ALK0.65880645
97LIMK10.63842533
98PAK20.63204544
99OBSCN0.63071646
100TIE10.62850051
101EPHA30.62350818
102DYRK1B0.61146711
103AKT20.60877202
104STK100.60669799
105DDR20.59398654
106CSNK2A20.58835548
107PDGFRA0.58330572
108CAMK2G0.58006481
109MAP2K20.57916034
110CCNB10.56326822
111CSNK2A10.56085829
112VRK10.55534502
113PRKCI0.55215252
114PBK0.55072345
115ERBB20.54742217
116CDK180.52835853
117CDK150.52672265
118CDK120.50241623
119CSNK1E0.49878782
120ZAK0.49011969
121MAPKAPK30.48926748
122NTRK20.47931537
123PINK10.47841792
124FGFR10.46877361
125AKT30.46817475
126NUAK10.46677489
127SMG10.46396185
128BRAF0.43721782
129ATM0.43136247
130CDK10.42547673
131PRKCG0.41797373
132PRKD30.41328340
133ZAP700.41027979
134RPS6KA10.40575444
135MATK0.38761472
136CDK50.38426851
137MKNK20.37849728
138CDK60.37482690
139RPS6KC10.36561118
140RPS6KL10.36561118
141PRKACB0.35669956
142ERN10.34745242
143MINK10.33537166
144DAPK30.32905461
145WNK30.32128997
146TAOK10.31199314
147IRAK30.29983011
148STK30.29909877
149CAMK2B0.29610612
150RPS6KA20.29577006
151CDK11A0.27863022
152CDK80.27747270

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.18859654
2Ribosome_Homo sapiens_hsa030103.62430675
3Proteasome_Homo sapiens_hsa030503.59744716
4Spliceosome_Homo sapiens_hsa030403.48839811
5Mismatch repair_Homo sapiens_hsa034303.26218863
6RNA transport_Homo sapiens_hsa030133.26084309
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.23625865
8Base excision repair_Homo sapiens_hsa034103.01917719
9RNA polymerase_Homo sapiens_hsa030202.91013265
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.70790553
11Cell cycle_Homo sapiens_hsa041102.45723228
12Pyrimidine metabolism_Homo sapiens_hsa002402.31985687
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.26044282
14Nucleotide excision repair_Homo sapiens_hsa034202.24820809
15Fatty acid elongation_Homo sapiens_hsa000622.12529975
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.03303104
17Homologous recombination_Homo sapiens_hsa034401.92541226
18One carbon pool by folate_Homo sapiens_hsa006701.73657203
19Biosynthesis of amino acids_Homo sapiens_hsa012301.68282245
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61733330
21Alzheimers disease_Homo sapiens_hsa050101.60569073
22mRNA surveillance pathway_Homo sapiens_hsa030151.60054235
23p53 signaling pathway_Homo sapiens_hsa041151.57221838
24Selenocompound metabolism_Homo sapiens_hsa004501.51657897
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46534862
26Carbon metabolism_Homo sapiens_hsa012001.45415736
27Synaptic vesicle cycle_Homo sapiens_hsa047211.41052848
28Vibrio cholerae infection_Homo sapiens_hsa051101.40338650
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.35280464
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.32835749
31RNA degradation_Homo sapiens_hsa030181.32421615
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25451284
33Folate biosynthesis_Homo sapiens_hsa007901.24154915
34Collecting duct acid secretion_Homo sapiens_hsa049661.24127941
35Sulfur relay system_Homo sapiens_hsa041221.24092569
36Phenylalanine metabolism_Homo sapiens_hsa003601.23892255
37Protein export_Homo sapiens_hsa030601.23722993
38Pentose phosphate pathway_Homo sapiens_hsa000301.23496296
39Oocyte meiosis_Homo sapiens_hsa041141.23391038
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21960511
41Vitamin B6 metabolism_Homo sapiens_hsa007501.17568780
42Purine metabolism_Homo sapiens_hsa002301.16634588
43Basal transcription factors_Homo sapiens_hsa030221.16120177
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15383711
45Basal cell carcinoma_Homo sapiens_hsa052171.11944481
46Epstein-Barr virus infection_Homo sapiens_hsa051691.08065384
47Fanconi anemia pathway_Homo sapiens_hsa034601.05686037
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.05662998
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05185604
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.04714862
51Peroxisome_Homo sapiens_hsa041461.04135817
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98737753
53Fructose and mannose metabolism_Homo sapiens_hsa000510.97646982
54Hippo signaling pathway_Homo sapiens_hsa043900.96851324
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95737309
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.94517068
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91552372
58Sulfur metabolism_Homo sapiens_hsa009200.90642733
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.90078487
60Hedgehog signaling pathway_Homo sapiens_hsa043400.89088219
61Thyroid cancer_Homo sapiens_hsa052160.88293895
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87990783
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83112326
64Notch signaling pathway_Homo sapiens_hsa043300.80560112
65Pyruvate metabolism_Homo sapiens_hsa006200.80049338
66Viral carcinogenesis_Homo sapiens_hsa052030.79305324
67Steroid biosynthesis_Homo sapiens_hsa001000.78107627
68Huntingtons disease_Homo sapiens_hsa050160.77210097
69Parkinsons disease_Homo sapiens_hsa050120.75871140
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75434778
71Tyrosine metabolism_Homo sapiens_hsa003500.74301565
72HTLV-I infection_Homo sapiens_hsa051660.73938505
73Fatty acid metabolism_Homo sapiens_hsa012120.72945342
74Bladder cancer_Homo sapiens_hsa052190.72230783
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.69592773
76Galactose metabolism_Homo sapiens_hsa000520.66864714
77Colorectal cancer_Homo sapiens_hsa052100.62637332
78beta-Alanine metabolism_Homo sapiens_hsa004100.60221651
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57573863
80Butanoate metabolism_Homo sapiens_hsa006500.55721990
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54659137
82Nicotine addiction_Homo sapiens_hsa050330.52110861
83Non-homologous end-joining_Homo sapiens_hsa034500.51731753
84mTOR signaling pathway_Homo sapiens_hsa041500.50611171
85N-Glycan biosynthesis_Homo sapiens_hsa005100.50362570
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50265876
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48719541
88Small cell lung cancer_Homo sapiens_hsa052220.48543281
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48249603
90Systemic lupus erythematosus_Homo sapiens_hsa053220.46968002
91AMPK signaling pathway_Homo sapiens_hsa041520.46854328
92Alcoholism_Homo sapiens_hsa050340.46464553
93Endometrial cancer_Homo sapiens_hsa052130.45653787
94Shigellosis_Homo sapiens_hsa051310.45232127
95Cardiac muscle contraction_Homo sapiens_hsa042600.44990389
96MicroRNAs in cancer_Homo sapiens_hsa052060.43118500
97Antigen processing and presentation_Homo sapiens_hsa046120.41869510
98Glutathione metabolism_Homo sapiens_hsa004800.41561383
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41024676
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40985573
101Arginine and proline metabolism_Homo sapiens_hsa003300.40333128
102HIF-1 signaling pathway_Homo sapiens_hsa040660.39263440
103Wnt signaling pathway_Homo sapiens_hsa043100.39129890
104Regulation of autophagy_Homo sapiens_hsa041400.38844563
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38754094
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.38639146
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38067964
108Chronic myeloid leukemia_Homo sapiens_hsa052200.37767021
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36780958
110GABAergic synapse_Homo sapiens_hsa047270.36404097
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36130214
112Proteoglycans in cancer_Homo sapiens_hsa052050.31313128
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30880402
114Adherens junction_Homo sapiens_hsa045200.30493858
115Insulin signaling pathway_Homo sapiens_hsa049100.29468515
116Arginine biosynthesis_Homo sapiens_hsa002200.29247176
117Oxidative phosphorylation_Homo sapiens_hsa001900.29143195
118Non-small cell lung cancer_Homo sapiens_hsa052230.28980902
119Fatty acid degradation_Homo sapiens_hsa000710.28955024
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28838618
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28649759
122Tight junction_Homo sapiens_hsa045300.28581860
123Metabolic pathways_Homo sapiens_hsa011000.28464017
124Glucagon signaling pathway_Homo sapiens_hsa049220.28070758
125Acute myeloid leukemia_Homo sapiens_hsa052210.27014080
126TGF-beta signaling pathway_Homo sapiens_hsa043500.26575484
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26191970
128Propanoate metabolism_Homo sapiens_hsa006400.25901123
129Pathways in cancer_Homo sapiens_hsa052000.25026614
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.23755963
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23255967
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23052885
133Fat digestion and absorption_Homo sapiens_hsa049750.18855609
134Viral myocarditis_Homo sapiens_hsa054160.17673652
135Herpes simplex infection_Homo sapiens_hsa051680.17187218
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15320368
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14239083
138Salmonella infection_Homo sapiens_hsa051320.09690021
139Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.06729990
140Lysosome_Homo sapiens_hsa041420.06324015

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