QRFP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. The encoded products are members of the RFamide family of neuropeptides, characterized by their common protein C-terminus consisting of an arginine (R) and an amidated phenylalanine (F). These products include the neuropeptides 26RFa and the N-terminally extended form, 43RFa. Both of these neuropeptides bind to the pyroglutamylated RFamide peptide receptor (QRFPR) and may regulate blood pressure, reproduction and food intake in rodents. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mesodermal cell differentiation (GO:0048333)9.54691630
2negative regulation of macrophage differentiation (GO:0045650)9.30077279
3regulation of gonadotropin secretion (GO:0032276)8.77616251
4hemoglobin metabolic process (GO:0020027)8.02048723
5response to sterol (GO:0036314)7.73863094
6eyelid development in camera-type eye (GO:0061029)7.45896946
7response to follicle-stimulating hormone (GO:0032354)7.33839479
8positive regulation of astrocyte differentiation (GO:0048711)7.26329599
9endocrine hormone secretion (GO:0060986)6.96046448
10positive regulation of osteoblast proliferation (GO:0033690)6.71223856
11negative regulation of cell aging (GO:0090344)6.67134721
12GDP-mannose metabolic process (GO:0019673)6.60795882
13cellular response to cholesterol (GO:0071397)6.42891470
14negative regulation of hormone metabolic process (GO:0032351)6.23052108
15negative regulation of hormone biosynthetic process (GO:0032353)6.23052108
16meiotic chromosome segregation (GO:0045132)6.04901572
17cellular response to ATP (GO:0071318)5.90479234
18adenosine receptor signaling pathway (GO:0001973)5.71250999
19regulation of glucocorticoid metabolic process (GO:0031943)5.65187131
20atrioventricular valve morphogenesis (GO:0003181)5.58825398
21regulation of interferon-gamma biosynthetic process (GO:0045072)5.57386411
22pericardium development (GO:0060039)5.55665753
23positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)5.54798108
24activation of protein kinase B activity (GO:0032148)5.49876958
25pathway-restricted SMAD protein phosphorylation (GO:0060389)5.39688763
26regulation of Wnt signaling pathway involved in heart development (GO:0003307)5.37123199
27positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)5.34738656
28positive regulation of p38MAPK cascade (GO:1900745)5.34581161
29endocardial cushion morphogenesis (GO:0003203)5.33950242
30pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)5.27546641
31DNA strand renaturation (GO:0000733)5.10091075
32activin receptor signaling pathway (GO:0032924)5.08577338
33UV protection (GO:0009650)5.04972572
34pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)5.02928942
35UMP metabolic process (GO:0046049)5.02928942
36pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)5.02928942
37UMP biosynthetic process (GO:0006222)5.02928942
38G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.94790617
39positive regulation of interleukin-8 secretion (GO:2000484)4.93095822
40endodermal cell differentiation (GO:0035987)4.85186422
41regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)4.83180629
42cell adhesion mediated by integrin (GO:0033627)4.74213701
43rRNA methylation (GO:0031167)4.73454157
44pyrimidine nucleoside monophosphate metabolic process (GO:0009129)4.71310230
45mesenchyme morphogenesis (GO:0072132)4.67634579
46leukocyte aggregation (GO:0070486)4.66698720
47positive regulation of Rho protein signal transduction (GO:0035025)4.60873214
48cell proliferation involved in kidney development (GO:0072111)4.58060429
49lens fiber cell differentiation (GO:0070306)4.55414732
50response to cholesterol (GO:0070723)4.54748160
51adenine nucleotide transport (GO:0051503)4.50713918
52regulation of odontogenesis of dentin-containing tooth (GO:0042487)4.46660205
53tyrosine phosphorylation of STAT protein (GO:0007260)4.45075150
54regulation of B cell differentiation (GO:0045577)4.42168294
55purine ribonucleotide transport (GO:0015868)4.37097176
56cellular response to gonadotropin stimulus (GO:0071371)4.33071176
57folic acid metabolic process (GO:0046655)4.31817543
58rRNA modification (GO:0000154)4.29701664
59mesenchymal cell proliferation (GO:0010463)4.17857218
60sialylation (GO:0097503)4.12947179
61negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)4.10708961
62positive regulation of odontogenesis (GO:0042482)4.10212417
63omega-hydroxylase P450 pathway (GO:0097267)4.06230718
64centrosome duplication (GO:0051298)4.03785957
65epoxygenase P450 pathway (GO:0019373)3.95302209
66granulocyte differentiation (GO:0030851)3.94952698
67regulation of macrophage differentiation (GO:0045649)3.93704853
68nucleotide-sugar biosynthetic process (GO:0009226)3.93296253
69ganglioside metabolic process (GO:0001573)3.92867923
70purinergic nucleotide receptor signaling pathway (GO:0035590)3.92772677
71negative regulation of B cell activation (GO:0050869)3.87208952
72regulation of synapse structural plasticity (GO:0051823)3.80467620
73negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.79942280
74regulation of steroid hormone biosynthetic process (GO:0090030)3.67283308
75negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.67246882
76mature B cell differentiation involved in immune response (GO:0002313)3.65447794
77regulation of cytokine production involved in inflammatory response (GO:1900015)3.65257270
78positive regulation of glial cell differentiation (GO:0045687)3.61937883
79SMAD protein signal transduction (GO:0060395)3.61387980
80barbed-end actin filament capping (GO:0051016)3.60872659
81purine nucleotide transport (GO:0015865)3.59437915
82regulation of skeletal muscle contraction (GO:0014819)3.59019124
83protein destabilization (GO:0031648)3.56988990
84regulation of p38MAPK cascade (GO:1900744)3.56797780
85negative regulation of interferon-gamma production (GO:0032689)3.56585997
86positive regulation of erythrocyte differentiation (GO:0045648)3.56395659
87axon ensheathment in central nervous system (GO:0032291)3.52907108
88central nervous system myelination (GO:0022010)3.52907108
89response to gonadotropin (GO:0034698)3.51250093
90response to peptidoglycan (GO:0032494)3.50942254
91G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.46921747
92response to ATP (GO:0033198)3.46450178
93regulation of astrocyte differentiation (GO:0048710)3.44927855
94membrane invagination (GO:0010324)3.44265116
95regulation of cell aging (GO:0090342)3.39443109
96mannose metabolic process (GO:0006013)3.39038344
97semaphorin-plexin signaling pathway (GO:0071526)3.38768571
98cardiac epithelial to mesenchymal transition (GO:0060317)3.37494850
99spindle assembly (GO:0051225)3.36304949
100proline biosynthetic process (GO:0006561)3.34938112
101hemidesmosome assembly (GO:0031581)3.34444464
102negative regulation of cardiac muscle tissue development (GO:0055026)3.34081888
103sphingomyelin metabolic process (GO:0006684)3.33126980
104pyrimidine nucleobase catabolic process (GO:0006208)3.32975142
105regulation of glomerular filtration (GO:0003093)3.32624574
106DNA replication checkpoint (GO:0000076)3.32260726
107histone phosphorylation (GO:0016572)3.31415216
108regulation of endocrine process (GO:0044060)3.29210543
109negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.25378965
110negative regulation of cell killing (GO:0031342)3.25378965
111protein retention in ER lumen (GO:0006621)3.21647894
112purinergic receptor signaling pathway (GO:0035587)3.19697916
113regulation of osteoblast proliferation (GO:0033688)3.18018523
114positive regulation of gliogenesis (GO:0014015)3.17127784
115nucleoside transmembrane transport (GO:1901642)3.17021476
116positive regulation of systemic arterial blood pressure (GO:0003084)3.16822170
117cell surface receptor signaling pathway involved in heart development (GO:0061311)3.14967368
118regulation of translational fidelity (GO:0006450)3.13497594
119ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.12528093
120nucleoside bisphosphate biosynthetic process (GO:0033866)3.12528093
121purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.12528093
122mesenchymal cell differentiation (GO:0048762)3.10826632
123type B pancreatic cell proliferation (GO:0044342)3.10216446
124negative regulation of cell size (GO:0045792)3.09890277
125positive regulation of protein kinase C signaling (GO:0090037)3.09708515
126positive regulation of cartilage development (GO:0061036)3.06152242
127protein carboxylation (GO:0018214)3.05062818
128peptidyl-glutamic acid carboxylation (GO:0017187)3.05062818
129regulation of nuclear cell cycle DNA replication (GO:0033262)3.03717696
130thrombin receptor signaling pathway (GO:0070493)3.03144950
131protein hydroxylation (GO:0018126)3.02979989
132negative regulation of cytokine biosynthetic process (GO:0042036)3.02574212
133nuclear envelope organization (GO:0006998)3.02177557
134definitive hemopoiesis (GO:0060216)3.02120853
135regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.01771200
136regulation of T cell tolerance induction (GO:0002664)3.00188569
137maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.97841822
138positive regulation of reproductive process (GO:2000243)2.97780405
139focal adhesion assembly (GO:0048041)2.97598827
140cell-substrate adherens junction assembly (GO:0007045)2.97598827
141regulation of interleukin-8 secretion (GO:2000482)2.96604465
142heart valve morphogenesis (GO:0003179)2.95806654
143negative regulation of mRNA processing (GO:0050686)2.94941936
144heterotypic cell-cell adhesion (GO:0034113)2.91966076
145sensory perception of taste (GO:0050909)2.89355282
146regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.87076966
147urinary tract smooth muscle contraction (GO:0014848)2.82574905
148platelet dense granule organization (GO:0060155)2.82481117
149actin filament bundle organization (GO:0061572)2.82302092
150actin filament bundle assembly (GO:0051017)2.82302092
151regulation of cardiac muscle cell differentiation (GO:2000725)2.80520319
152pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.79270838
153mitotic cell cycle arrest (GO:0071850)2.78503379
154negative regulation of alcohol biosynthetic process (GO:1902931)2.77068401
155modulation by virus of host process (GO:0019054)2.73799241
156regulation of mammary gland epithelial cell proliferation (GO:0033599)2.71791092
157pyrimidine nucleotide biosynthetic process (GO:0006221)2.70806872
158chondrocyte proliferation (GO:0035988)2.69745472
159negative regulation of lymphocyte differentiation (GO:0045620)2.69508326
160phagocytosis, engulfment (GO:0006911)2.69390181
161nuclear envelope disassembly (GO:0051081)2.68376213
162membrane disassembly (GO:0030397)2.68376213
163DNA duplex unwinding (GO:0032508)2.68027224
164negative T cell selection (GO:0043383)2.66324322
165negative regulation of mRNA metabolic process (GO:1903312)2.66157504
166mammary gland epithelial cell proliferation (GO:0033598)2.65835552
167N-terminal protein amino acid modification (GO:0031365)2.65808738
168pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.65750711
169nucleotide transmembrane transport (GO:1901679)2.64823433
170cellular response to vitamin D (GO:0071305)2.63767162
171adherens junction assembly (GO:0034333)2.63505941
172DNA unwinding involved in DNA replication (GO:0006268)2.63365217
173planar cell polarity pathway involved in neural tube closure (GO:0090179)2.63149366
174negative regulation of myeloid leukocyte differentiation (GO:0002762)2.62709647
175pyrimidine nucleoside biosynthetic process (GO:0046134)2.61575443
176cell-substrate junction assembly (GO:0007044)2.61296146
177renal system process involved in regulation of blood volume (GO:0001977)2.59611314
178regulation of uterine smooth muscle contraction (GO:0070472)2.59584869
179negative thymic T cell selection (GO:0045060)2.59577996
180stress fiber assembly (GO:0043149)2.57930400
181germ cell migration (GO:0008354)2.57306673
182G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.57258553
183positive regulation of heat generation (GO:0031652)2.57060725
184basement membrane organization (GO:0071711)2.54926402
185mitotic nuclear envelope disassembly (GO:0007077)2.54545415
186negative regulation of JAK-STAT cascade (GO:0046426)2.54329518
187pinocytosis (GO:0006907)2.53848598
188positive regulation of phosphatase activity (GO:0010922)2.53319221
189cranial nerve morphogenesis (GO:0021602)2.50805865
190modulation by symbiont of host cellular process (GO:0044068)2.49876256
191nucleoside transport (GO:0015858)2.48743422
192cellular response to alcohol (GO:0097306)2.45864527
193positive regulation of cell-cell adhesion (GO:0022409)2.44497751
194epithelial to mesenchymal transition (GO:0001837)2.40999926
195regulation of alkaline phosphatase activity (GO:0010692)2.40998311
196positive regulation of protein autophosphorylation (GO:0031954)2.39579315
197hair follicle development (GO:0001942)2.38827391
198activated T cell proliferation (GO:0050798)2.36346508
199cellular response to follicle-stimulating hormone stimulus (GO:0071372)10.9828717
200cellular response to sterol (GO:0036315)10.6634231

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.17403313
2VDR_21846776_ChIP-Seq_THP-1_Human4.37492171
3SMAD_19615063_ChIP-ChIP_OVARY_Human4.07972992
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.35566897
5E2F7_22180533_ChIP-Seq_HELA_Human3.31709331
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.93207403
7* LXR_22292898_ChIP-Seq_THP-1_Human2.84057569
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.81278435
9TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.76421485
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.61111703
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.57407252
12MYC_22102868_ChIP-Seq_BL_Human2.54518786
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.47989062
14EZH2_22144423_ChIP-Seq_EOC_Human2.36955341
15RACK7_27058665_Chip-Seq_MCF-7_Human2.35326573
16DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.31844015
17AR_21572438_ChIP-Seq_LNCaP_Human2.30590960
18VDR_24763502_ChIP-Seq_THP-1_Human2.28597661
19P68_20966046_ChIP-Seq_HELA_Human2.26267938
20RUNX_20019798_ChIP-Seq_JUKART_Human2.19855831
21ELK3_25401928_ChIP-Seq_HUVEC_Human2.16370970
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15744892
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.14394091
24MAF_26560356_Chip-Seq_TH2_Human2.13912721
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.10040346
26PCGF2_27294783_Chip-Seq_NPCs_Mouse2.07425098
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.06375964
28EGR1_19374776_ChIP-ChIP_THP-1_Human2.03507387
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03365942
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.93876990
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93240087
32XRN2_22483619_ChIP-Seq_HELA_Human1.92554961
33MAF_26560356_Chip-Seq_TH1_Human1.90744785
34TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.87348111
35KDM2B_26808549_Chip-Seq_DND41_Human1.86961702
36TCF7_22412390_ChIP-Seq_EML_Mouse1.83606882
37TP53_16413492_ChIP-PET_HCT116_Human1.81982697
38FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.77847302
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76094417
40CTCF_27219007_Chip-Seq_ERYTHROID_Human1.74876182
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74519827
42TP53_18474530_ChIP-ChIP_U2OS_Human1.74441265
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.73054346
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.70541198
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.67711629
46BCL6_27268052_Chip-Seq_Bcells_Human1.66955432
47BCOR_27268052_Chip-Seq_Bcells_Human1.64913987
48CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.63640099
49ATF3_27146783_Chip-Seq_COLON_Human1.62437083
50MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.62037682
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.61611668
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61305319
53SA1_27219007_Chip-Seq_ERYTHROID_Human1.58438108
54AHR_22903824_ChIP-Seq_MCF-7_Human1.56873119
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56738799
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55574286
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.55569002
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.53933835
59CTCF_21964334_Chip-Seq_Bcells_Human1.52919669
60CTNNB1_20460455_ChIP-Seq_HCT116_Human1.52648147
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.52454363
62E2F1_20622854_ChIP-Seq_HELA_Human1.52157399
63PHF8_20622854_ChIP-Seq_HELA_Human1.51854229
64PPAR_26484153_Chip-Seq_NCI-H1993_Human1.51320220
65CTCF_27219007_Chip-Seq_Bcells_Human1.50712894
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.50419873
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50129302
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49276288
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.48966938
70UTX_26944678_Chip-Seq_JUKART_Human1.48783629
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.47715227
72* TP53_22127205_ChIP-Seq_IMR90_Human1.47367930
73NCOR1_26117541_ChIP-Seq_K562_Human1.43680225
74CJUN_26792858_Chip-Seq_BT549_Human1.43077615
75RARA_24833708_ChIP-Seq_LIVER_Mouse1.42386973
76ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42234650
77EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.42085825
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41707954
79* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41161980
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.39705015
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39430098
82CREB1_26743006_Chip-Seq_LNCaP_Human1.38708834
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37802310
84UBF1/2_26484160_Chip-Seq_HMECs_Human1.37022503
85* RARB_24833708_ChIP-Seq_LIVER_Mouse1.36992329
86CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.35867634
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.35619041
88SMC4_20622854_ChIP-Seq_HELA_Human1.34664278
89EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33802211
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33268168
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32776593
92DCP1A_22483619_ChIP-Seq_HELA_Human1.31956361
93UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31864389
94HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.31599793
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31192453
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.30739565
97SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30438468
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29724971
99SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29325457
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29042097
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.28392230
102JARID2_20064375_ChIP-Seq_MESCs_Mouse1.28119165
103KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27938908
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27883756
105FOXP1_21924763_ChIP-Seq_HESCs_Human1.27205382
106TP63_17297297_ChIP-ChIP_HaCaT_Human1.26648914
107SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.26504109
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.26277167
109ZNF263_19887448_ChIP-Seq_K562_Human1.26089041
110* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.26047488
111PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25804954
112MYC_18555785_ChIP-Seq_MESCs_Mouse1.25597129
113EZH2_27294783_Chip-Seq_NPCs_Mouse1.25270657
114SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.24956480
115SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.24956480
116OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24947591
117* KDM2B_26808549_Chip-Seq_K562_Human1.24587305
118BRD4_25478319_ChIP-Seq_HGPS_Human1.23957630
119P300_18555785_Chip-Seq_ESCs_Mouse1.22796326
120* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22650725
121P53_22387025_ChIP-Seq_ESCs_Mouse1.22645829
122ETS1_21867929_ChIP-Seq_TH2_Mouse1.22428953
123NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21586745
124SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21557714
125MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21542715
126SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.21362451
127E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21193984
128* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21019264
129KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20824493
130KDM2B_26808549_Chip-Seq_JURKAT_Human1.20492986
131MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18576889
132P300_27058665_Chip-Seq_ZR-75-30cells_Human1.18207041
133CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18095606
134ESR2_21235772_ChIP-Seq_MCF-7_Human1.17758208
135CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17711420
136MYB_26560356_Chip-Seq_TH2_Human1.17707220
137* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17594913
138NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17510552
139NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17510552
140KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17438513
141VDR_24787735_ChIP-Seq_THP-1_Human1.17358096
142CIITA_25753668_ChIP-Seq_RAJI_Human1.17287539
143CTCF_21964334_ChIP-Seq_BJAB-B_Human1.17121364
144PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16965181
145MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16778220
146TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16760932
147STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16360833
148EP300_21415370_ChIP-Seq_HL-1_Mouse1.16319723
149PRDM14_20953172_ChIP-Seq_ESCs_Human1.15446629
150SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14940392
151ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14833582
152SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.14599351
153SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14298173
154* PU1_27457419_Chip-Seq_LIVER_Mouse1.13281735
155* OCT4_18555785_Chip-Seq_ESCs_Mouse1.13273140
156DROSHA_22980978_ChIP-Seq_HELA_Human1.13271384
157CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12806138
158DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12584744
159SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12330528
160HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12077556
161E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10350626
162SCL_19346495_ChIP-Seq_HPC-7_Human1.09944826
163EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09632869
164RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09315013
165CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09078272
166BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09035594
167FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08941075
168BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08776179
169* RUNX1_27514584_Chip-Seq_MCF-7_Human1.07341852
170JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05989689
171E2F1_18555785_Chip-Seq_ESCs_Mouse1.05788057
172CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04824759
173SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04370191
174YY1_22570637_ChIP-Seq_MALME-3M_Human1.04353477
175FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03737066
176NMYC_18555785_Chip-Seq_ESCs_Mouse1.03699098
177PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03566349
178KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03375405
179P300_19829295_ChIP-Seq_ESCs_Human1.02795723
180RUNX1_22412390_ChIP-Seq_EML_Mouse1.02618609
181RUNX1_27457419_Chip-Seq_LIVER_Mouse1.02591736
182RNF2_18974828_ChIP-Seq_MESCs_Mouse1.02518422
183EZH2_18974828_ChIP-Seq_MESCs_Mouse1.02518422
184POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02352999
185GABP_19822575_ChIP-Seq_HepG2_Human1.02123384
186JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01994687
187CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00895060
188ER_23166858_ChIP-Seq_MCF-7_Human1.00409828
189JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00396760
190ZFX_18555785_Chip-Seq_ESCs_Mouse0.99347657
191ESRRB_18555785_Chip-Seq_ESCs_Mouse0.98668534
192EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98405969
193RNF2_27304074_Chip-Seq_ESCs_Mouse0.98403103
194SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97955354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001299_abnormal_eye_distance/6.34485881
2MP0005187_abnormal_penis_morphology5.88973156
3MP0004134_abnormal_chest_morphology4.54278012
4MP0005171_absent_coat_pigmentation4.35904389
5MP0005076_abnormal_cell_differentiation4.32079693
6MP0003705_abnormal_hypodermis_morpholog3.93501588
7MP0005174_abnormal_tail_pigmentation3.74599653
8MP0001986_abnormal_taste_sensitivity3.49081206
9MP0005623_abnormal_meninges_morphology3.27385645
10MP0009250_abnormal_appendicular_skeleto3.08350941
11MP0010352_gastrointestinal_tract_polyps3.06500450
12MP0003136_yellow_coat_color3.00191820
13MP0003111_abnormal_nucleus_morphology2.71865244
14MP0005451_abnormal_body_composition2.54494275
15MP0009278_abnormal_bone_marrow2.51695768
16MP0001188_hyperpigmentation2.45858675
17MP0009053_abnormal_anal_canal2.42769685
18MP0001873_stomach_inflammation2.41776503
19MP0005083_abnormal_biliary_tract2.31299012
20MP0002098_abnormal_vibrissa_morphology2.26841947
21MP0000566_synostosis2.24134786
22MP0009384_cardiac_valve_regurgitation2.23866033
23MP0000750_abnormal_muscle_regeneration2.20759525
24MP0003806_abnormal_nucleotide_metabolis2.08532960
25MP0008057_abnormal_DNA_replication1.95986904
26MP0001348_abnormal_lacrimal_gland1.83868557
27MP0000762_abnormal_tongue_morphology1.80353202
28MP0000751_myopathy1.78639945
29MP0005409_darkened_coat_color1.78480600
30MP0009780_abnormal_chondrocyte_physiolo1.76687998
31MP0002282_abnormal_trachea_morphology1.72061847
32MP0005058_abnormal_lysosome_morphology1.70286359
33MP0005397_hematopoietic_system_phenotyp1.68913612
34MP0001545_abnormal_hematopoietic_system1.68913612
35MP0003763_abnormal_thymus_physiology1.67006271
36MP0004808_abnormal_hematopoietic_stem1.66469792
37MP0005257_abnormal_intraocular_pressure1.66023859
38MP0000163_abnormal_cartilage_morphology1.65480588
39MP0000920_abnormal_myelination1.63955357
40MP0003077_abnormal_cell_cycle1.63496652
41MP0003937_abnormal_limbs/digits/tail_de1.63178767
42MP0001340_abnormal_eyelid_morphology1.62435021
43MP0004233_abnormal_muscle_weight1.60937736
44MP0002166_altered_tumor_susceptibility1.60431418
45MP0005410_abnormal_fertilization1.59226279
46MP0003943_abnormal_hepatobiliary_system1.58843172
47MP0008438_abnormal_cutaneous_collagen1.55636857
48MP0009697_abnormal_copulation1.54726952
49MP0000858_altered_metastatic_potential1.54413144
50MP0004883_abnormal_blood_vessel1.52272555
51MP0001958_emphysema1.51276946
52MP0003950_abnormal_plasma_membrane1.48518635
53MP0005423_abnormal_somatic_nervous1.45257606
54MP0000015_abnormal_ear_pigmentation1.44473653
55MP0010094_abnormal_chromosome_stability1.43689220
56MP0002234_abnormal_pharynx_morphology1.41971717
57MP0009840_abnormal_foam_cell1.41788324
58MP0000383_abnormal_hair_follicle1.41552957
59MP0000733_abnormal_muscle_development1.41485877
60MP0002933_joint_inflammation1.40651270
61MP0004185_abnormal_adipocyte_glucose1.40267269
62MP0005501_abnormal_skin_physiology1.38330271
63MP0001661_extended_life_span1.34379564
64MP0002396_abnormal_hematopoietic_system1.33926034
65MP0000647_abnormal_sebaceous_gland1.33763588
66MP0000003_abnormal_adipose_tissue1.31921207
67MP0003693_abnormal_embryo_hatching1.31243781
68MP0003385_abnormal_body_wall1.30082388
69MP0004858_abnormal_nervous_system1.29435471
70MP0000428_abnormal_craniofacial_morphol1.27585046
71MP0000432_abnormal_head_morphology1.25318840
72MP0004957_abnormal_blastocyst_morpholog1.25205053
73MP0003091_abnormal_cell_migration1.25061456
74MP0001663_abnormal_digestive_system1.24532415
75MP0002006_tumorigenesis1.23248237
76MP0005330_cardiomyopathy1.21685863
77MP0001756_abnormal_urination1.21234651
78MP0005381_digestive/alimentary_phenotyp1.20780985
79MP0005367_renal/urinary_system_phenotyp1.20358929
80MP0000516_abnormal_urinary_system1.20358929
81MP0005387_immune_system_phenotype1.12212560
82MP0001790_abnormal_immune_system1.12212560
83MP0002019_abnormal_tumor_incidence1.10959469
84MP0002102_abnormal_ear_morphology1.08901859
85MP0004381_abnormal_hair_follicle1.08704125
86MP0003868_abnormal_feces_composition1.07053048
87MP0000013_abnormal_adipose_tissue1.06340669
88MP0000613_abnormal_salivary_gland1.05637507
89MP0010307_abnormal_tumor_latency1.05444672
90MP0003936_abnormal_reproductive_system1.03523581
91MP0005621_abnormal_cell_physiology1.03203335
92MP0000538_abnormal_urinary_bladder1.02780048
93MP0008007_abnormal_cellular_replicative1.02701383
94MP0000490_abnormal_crypts_of1.01597253
95MP0003755_abnormal_palate_morphology1.01387172
96MP0010678_abnormal_skin_adnexa1.00972632
97MP0002896_abnormal_bone_mineralization0.99636618
98MP0004270_analgesia0.99457365
99MP0003880_abnormal_central_pattern0.99280205
100MP0000465_gastrointestinal_hemorrhage0.97361082
101MP0003279_aneurysm0.97222885
102MP0003303_peritoneal_inflammation0.97199271
103MP0000759_abnormal_skeletal_muscle0.96756541
104MP0000350_abnormal_cell_proliferation0.96284521
105MP0009931_abnormal_skin_appearance0.96197586
106MP0002113_abnormal_skeleton_development0.95913889
107MP0002796_impaired_skin_barrier0.95509051
108MP0002116_abnormal_craniofacial_bone0.94174275
109MP0005375_adipose_tissue_phenotype0.93866139
110MP0001968_abnormal_touch/_nociception0.93804012
111MP0000678_abnormal_parathyroid_gland0.93017249
112MP0004510_myositis0.92213463
113MP0003656_abnormal_erythrocyte_physiolo0.90974670
114MP0002115_abnormal_skeleton_extremities0.90870214
115MP0002254_reproductive_system_inflammat0.90362747
116MP0002405_respiratory_system_inflammati0.89914951
117MP0010771_integument_phenotype0.89768814
118MP0001784_abnormal_fluid_regulation0.89056020
119MP0002925_abnormal_cardiovascular_devel0.88943440
120MP0003315_abnormal_perineum_morphology0.88408807
121MP0000537_abnormal_urethra_morphology0.88071895
122MP0004087_abnormal_muscle_fiber0.88060275
123MP0003935_abnormal_craniofacial_develop0.86156631
124MP0002932_abnormal_joint_morphology0.86078229
125MP0000703_abnormal_thymus_morphology0.84096154
126MP0002060_abnormal_skin_morphology0.83615117
127MP0003436_decreased_susceptibility_to0.83095340
128MP0008770_decreased_survivor_rate0.82853634
129MP0002109_abnormal_limb_morphology0.82331627
130MP0000377_abnormal_hair_follicle0.79835186
131MP0001346_abnormal_lacrimal_gland0.79418630
132MP0005023_abnormal_wound_healing0.79344558
133MP0002080_prenatal_lethality0.79039902
134MP0002998_abnormal_bone_remodeling0.78980799
135MP0005408_hypopigmentation0.78834047
136MP0005164_abnormal_response_to0.78780831
137MP0005671_abnormal_response_to0.78659628
138MP0002128_abnormal_blood_circulation0.78032020
139MP0000747_muscle_weakness0.77413505
140MP0000249_abnormal_blood_vessel0.76695845
141MP0008004_abnormal_stomach_pH0.76695093
142MP0003828_pulmonary_edema0.76565820
143MP0001664_abnormal_digestion0.76216611
144MP0004084_abnormal_cardiac_muscle0.74681996
145MP0003795_abnormal_bone_structure0.74387751
146MP0001672_abnormal_embryogenesis/_devel0.73775793
147MP0005380_embryogenesis_phenotype0.73775793
148MP0005220_abnormal_exocrine_pancreas0.72922880
149MP0003984_embryonic_growth_retardation0.72812867
150MP0002086_abnormal_extraembryonic_tissu0.72232193
151MP0000749_muscle_degeneration0.70647013
152MP0006082_CNS_inflammation0.69659089
153MP0000462_abnormal_digestive_system0.69532659
154MP0003453_abnormal_keratinocyte_physiol0.69070038
155MP0002088_abnormal_embryonic_growth/wei0.68174512
156MP0002089_abnormal_postnatal_growth/wei0.67833409
157MP0003448_altered_tumor_morphology0.66959012
158MP0002160_abnormal_reproductive_system0.66805511
159MP0001191_abnormal_skin_condition0.66706297
160MP0000767_abnormal_smooth_muscle0.66564017
161MP0003075_altered_response_to0.65447814
162MP0004130_abnormal_muscle_cell0.65073409
163MP0001800_abnormal_humoral_immune0.64886654
164MP0000049_abnormal_middle_ear0.64869829
165MP0002177_abnormal_outer_ear0.64785911
166MP0002420_abnormal_adaptive_immunity0.64703626
167MP0000358_abnormal_cell_content/0.64407364
168MP0005384_cellular_phenotype0.63884358
169MP0002009_preneoplasia0.63754168
170MP0006054_spinal_hemorrhage0.63634264
171MP0002723_abnormal_immune_serum0.62816243
172MP0002877_abnormal_melanocyte_morpholog0.62232245
173MP0003566_abnormal_cell_adhesion0.61961812
174MP0002751_abnormal_autonomic_nervous0.60882017
175MP0001819_abnormal_immune_cell0.60546418
176MP0001614_abnormal_blood_vessel0.58631149

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the phalanges of the 2nd finger (HP:0009541)8.53408960
2Abnormality of the 2nd finger (HP:0004100)6.42230765
3Thickened helices (HP:0000391)6.16176417
4Testicular atrophy (HP:0000029)6.05968213
5Abnormality of the middle phalanges of the toes (HP:0010183)5.87757105
6Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)5.46944148
7Thin bony cortex (HP:0002753)5.31826899
8Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)5.28374100
9Short hallux (HP:0010109)5.11904771
10Poikiloderma (HP:0001029)4.83124970
11Aplasia/Hypoplasia of the hallux (HP:0008362)4.74903023
12Rib fusion (HP:0000902)4.68355260
13Broad hallux (HP:0010055)4.43631037
14Abnormality of the middle phalanx of the 5th finger (HP:0004219)4.28142130
15Abnormality of the phalanges of the 5th finger (HP:0004213)4.20710804
16Annular pancreas (HP:0001734)4.19424298
172-3 toe syndactyly (HP:0004691)4.10216974
18Intestinal fistula (HP:0100819)4.01231700
19Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.98067374
20Turricephaly (HP:0000262)3.98020757
21Osteolytic defects of the hand bones (HP:0009699)3.95212720
22Osteolytic defects of the phalanges of the hand (HP:0009771)3.95212720
23Rectal fistula (HP:0100590)3.88975966
24Rectovaginal fistula (HP:0000143)3.88975966
25Autoamputation (HP:0001218)3.84941527
26Broad toe (HP:0001837)3.80230518
27Vaginal fistula (HP:0004320)3.77357947
28Popliteal pterygium (HP:0009756)3.73060309
29Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)3.64855597
30Facial hemangioma (HP:0000329)3.64220923
31Limited elbow extension (HP:0001377)3.55936673
32Selective tooth agenesis (HP:0001592)3.53592930
33Absent frontal sinuses (HP:0002688)3.52398554
34Dyschromatopsia (HP:0007641)3.46480529
35Abnormality of the intrinsic pathway (HP:0010989)3.32428753
36Aplasia of the musculature (HP:0100854)3.31804649
37Joint stiffness (HP:0001387)3.31777513
38Abnormality of the epiphyses of the hand (HP:0005924)3.17856569
39Onycholysis (HP:0001806)3.12515840
40Attenuation of retinal blood vessels (HP:0007843)3.10876326
41Short chin (HP:0000331)3.06981712
42Progressive muscle weakness (HP:0003323)2.99623339
43Acute myeloid leukemia (HP:0004808)2.93897360
44Squamous cell carcinoma (HP:0002860)2.92255548
45Hemorrhage of the eye (HP:0011885)2.89595543
46Bowing of the arm (HP:0006488)2.87945774
47Bowed forearm bones (HP:0003956)2.87945774
48Atrophic scars (HP:0001075)2.87855164
49Abnormality of pyrimidine metabolism (HP:0004353)2.87768761
50Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.86452916
51Aplasia involving bones of the upper limbs (HP:0009823)2.80667948
52Aplasia of the phalanges of the hand (HP:0009802)2.80667948
53Aplasia involving bones of the extremities (HP:0009825)2.80667948
54Akinesia (HP:0002304)2.76300386
55Sensory axonal neuropathy (HP:0003390)2.74825563
56Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.72562869
57Capillary hemangiomas (HP:0005306)2.72352913
58Milia (HP:0001056)2.67803007
59Urethral obstruction (HP:0000796)2.64930469
60Fibular hypoplasia (HP:0003038)2.64441158
61Patellar aplasia (HP:0006443)2.64024400
62Protrusio acetabuli (HP:0003179)2.61690594
63Bony spicule pigmentary retinopathy (HP:0007737)2.61422881
64Hallux valgus (HP:0001822)2.59903513
65Cervical subluxation (HP:0003308)2.59128860
66Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.58839593
67Degeneration of the lateral corticospinal tracts (HP:0002314)2.58839593
68Birth length less than 3rd percentile (HP:0003561)2.56886629
69Anteriorly placed anus (HP:0001545)2.56266285
70Delayed epiphyseal ossification (HP:0002663)2.55979305
71Facial diplegia (HP:0001349)2.55859948
72Preaxial foot polydactyly (HP:0001841)2.52772127
73Abnormality of incisor morphology (HP:0011063)2.48191196
74Fetal akinesia sequence (HP:0001989)2.47977124
75Deviation of the hallux (HP:0010051)2.45758158
76Aplasia/Hypoplasia of the patella (HP:0006498)2.45283976
77Coronal craniosynostosis (HP:0004440)2.45190700
78Cheilitis (HP:0100825)2.43904909
79Rectal prolapse (HP:0002035)2.43395567
80Mesangial abnormality (HP:0001966)2.43156635
81Abnormality of the middle phalanges of the hand (HP:0009833)2.42794380
82Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.41639313
83Atrioventricular block (HP:0001678)2.40738614
84Abnormality of placental membranes (HP:0011409)2.39827074
85Amniotic constriction ring (HP:0009775)2.39827074
86Macroorchidism (HP:0000053)2.39601840
87Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.39599322
88Short humerus (HP:0005792)2.38392641
89Wormian bones (HP:0002645)2.36509101
90Anhidrosis (HP:0000970)2.33901904
91Male infertility (HP:0003251)2.32592360
92Vertebral arch anomaly (HP:0008438)2.32545669
93Buphthalmos (HP:0000557)2.32340532
94Abnormality of the costochondral junction (HP:0000919)2.32200615
95T lymphocytopenia (HP:0005403)2.29657362
96Increased number of teeth (HP:0011069)2.23658606
97Achilles tendon contracture (HP:0001771)2.19580859
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.18275281
99Premature graying of hair (HP:0002216)2.17721855
100Enlarged epiphyses (HP:0010580)2.17564376
101Abnormal trabecular bone morphology (HP:0100671)2.16429567
102Chorioretinal atrophy (HP:0000533)2.16364322
103Premature rupture of membranes (HP:0001788)2.15671269
104Thin ribs (HP:0000883)2.13293413
105Abnormality of the right ventricle (HP:0001707)2.09544466
106Asymmetric septal hypertrophy (HP:0001670)2.09125544
107Syringomyelia (HP:0003396)2.07703095
108Spinal cord lesions (HP:0100561)2.07703095
109Sensorimotor neuropathy (HP:0007141)2.07097879
110Abnormality of T cell number (HP:0011839)2.06219391
111Congenital hip dislocation (HP:0001374)2.05017633
112Breast hypoplasia (HP:0003187)2.04497826
113Genu recurvatum (HP:0002816)2.03386031
114Flat occiput (HP:0005469)2.02634047
115Increased density of long bones (HP:0006392)2.02406913
116Aplasia/hypoplasia of the humerus (HP:0006507)2.01908078
117Vascular calcification (HP:0004934)2.01593221
118Choanal stenosis (HP:0000452)2.01491137
119Exotropia (HP:0000577)1.98960438
120Hyperacusis (HP:0010780)1.98823505
121Narrow nasal bridge (HP:0000446)1.98305403
122Broad face (HP:0000283)1.98057448
123Bradycardia (HP:0001662)1.97812890
124Absent toe (HP:0010760)1.97482814
125Widely patent fontanelles and sutures (HP:0004492)1.97422995
126Urinary urgency (HP:0000012)1.97406016
127Ragged-red muscle fibers (HP:0003200)1.97175742
128Pterygium (HP:0001059)1.96155091
129Narrow mouth (HP:0000160)1.94719102
130Neonatal respiratory distress (HP:0002643)1.94439882
131Ulnar deviation of finger (HP:0009465)1.93848691
132Progressive external ophthalmoplegia (HP:0000590)1.92502042
133Infantile muscular hypotonia (HP:0008947)1.91786249
134Abnormality of the frontal sinuses (HP:0002687)1.91368888
135Myotonia (HP:0002486)1.91068656
136Wide cranial sutures (HP:0010537)1.91002968
137Thoracolumbar scoliosis (HP:0002944)1.88763140
138Spondylolisthesis (HP:0003302)1.88656639
139Hypertriglyceridemia (HP:0002155)1.85939271
140Esophageal atresia (HP:0002032)1.85624836
141Ulnar bowing (HP:0003031)1.85247188
142Joint hemorrhage (HP:0005261)1.84362079
143Vertebral compression fractures (HP:0002953)1.82619697
144Cardiovascular calcification (HP:0011915)1.81519837
145Abnormality of the Achilles tendon (HP:0005109)1.81351714
146Tibial bowing (HP:0002982)1.81033340
147Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80748166
148Craniofacial hyperostosis (HP:0004493)1.80014548
149Aplasia/Hypoplasia of the fibula (HP:0006492)1.79355140
150Abnormality of the common coagulation pathway (HP:0010990)1.77520585
151Scanning speech (HP:0002168)1.77344484
152Neonatal onset (HP:0003623)1.77035720
153Dislocated radial head (HP:0003083)1.76764052
154Ureteral stenosis (HP:0000071)1.76455301
155Lower limb amyotrophy (HP:0007210)1.75119747
156Delayed closure of the anterior fontanelle (HP:0001476)1.74248951
157Oligodontia (HP:0000677)1.74100761
158Hypoalbuminemia (HP:0003073)1.73529521
159Abnormal albumin level (HP:0012116)1.73529521
160Absent thumb (HP:0009777)1.73323174
161Asymmetry of the thorax (HP:0001555)1.72146388
162Long nose (HP:0003189)1.72013966
163Flattened epiphyses (HP:0003071)1.70877205
164Ridged nail (HP:0001807)1.70653136
165Lumbar hyperlordosis (HP:0002938)1.70054394
166IgM deficiency (HP:0002850)1.69804153
167Narrow palate (HP:0000189)1.69558747
168Congenital glaucoma (HP:0001087)1.69487751
169Dysphonia (HP:0001618)1.69435749
170Flat capital femoral epiphysis (HP:0003370)1.68754827
171Mesomelia (HP:0003027)1.68473557
172Congenital stationary night blindness (HP:0007642)1.67581502
173Cerebral aneurysm (HP:0004944)1.67379724
174Urinary glycosaminoglycan excretion (HP:0003541)1.67205874
175Mucopolysacchariduria (HP:0008155)1.67205874
176Broad thumb (HP:0011304)1.67114070
177Increased connective tissue (HP:0009025)1.65935156
178Failure to thrive in infancy (HP:0001531)1.65841244
179Shallow orbits (HP:0000586)1.65403678
180Spina bifida occulta (HP:0003298)1.63987119
181Abnormality of the corticospinal tract (HP:0002492)1.63779837
182Submucous cleft hard palate (HP:0000176)1.63515468
183Zonular cataract (HP:0010920)1.63443004
184Fragile nails (HP:0001808)1.62958838
185Malnutrition (HP:0004395)1.62477691
186Bulbar palsy (HP:0001283)1.62423055
187Abnormality of the radial head (HP:0003995)1.62302272
188Choroideremia (HP:0001139)1.62054970
189Neonatal short-limb short stature (HP:0008921)1.61625381
190Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.61072022
191Widely spaced teeth (HP:0000687)1.60492663
192Hypophosphatemic rickets (HP:0004912)1.60086359
193Mitral valve prolapse (HP:0001634)1.59122961
194Delayed cranial suture closure (HP:0000270)1.58776951
195Vertebral hypoplasia (HP:0008417)1.57807782
196Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.57807782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL25.53417355
2STK104.51852685
3MAPK154.00754433
4TRIB33.73405766
5TTN3.19709462
6MKNK22.50756100
7ICK2.46984341
8EEF2K2.40103678
9ERN12.27959530
10MKNK12.26517357
11MAP3K22.25289046
12TAOK22.25088427
13IRAK32.23426131
14MST42.14249039
15ROCK22.08867591
16PIM22.07995192
17LRRK22.05853023
18MAP2K32.03032519
19WNK42.01608415
20FGR1.93481226
21EPHB21.91960189
22CDK121.76717854
23ITK1.76674642
24BLK1.75990483
25PRKCQ1.69415857
26PRKD21.69172181
27CSK1.65075042
28STK391.59994854
29MAPKAPK51.59620471
30KDR1.59371969
31TNIK1.54536746
32CSNK1A1L1.54016649
33PDGFRB1.52989904
34RIPK11.51336083
35LATS11.47068417
36HIPK21.42427630
37SMG11.40947825
38CASK1.40711189
39DMPK1.40656499
40MELK1.36704544
41MTOR1.32935334
42OXSR11.31925428
43ROCK11.31238499
44CDK81.28755115
45PTK61.26797113
46MST1R1.24197749
47PRPF4B1.24102589
48PKN21.20674740
49EPHB11.19321744
50CDK191.18909490
51WNK11.17700995
52CDC71.17043809
53FES1.14190519
54BMX1.13747569
55LCK1.12386377
56PAK21.11524694
57TESK11.11285240
58BRD41.10940198
59FGFR31.09911484
60MAP3K111.07563446
61MAPK111.04919830
62RPS6KL11.04892133
63RPS6KC11.04892133
64TESK21.02428253
65LATS21.01802030
66PAK41.01672029
67PTK21.00797862
68TNK21.00780539
69UHMK11.00543616
70MAP4K10.97474540
71FYN0.96913267
72CDK60.96512401
73MET0.96071568
74NEK20.94319526
75ZAP700.93700842
76RPS6KA50.93040499
77RPS6KA20.92860517
78CSNK1G20.91832934
79PRKCH0.91481198
80GRK60.91081536
81RPS6KA60.90653326
82PDPK10.89950175
83MAP3K80.89400854
84PDGFRA0.89392266
85IRAK20.88797930
86RPS6KA40.88444934
87EPHA20.88189998
88JAK30.88061757
89CCNB10.87400830
90CAMK1D0.87277347
91NME20.87117659
92TAOK10.86596361
93EGFR0.85539772
94INSR0.84557820
95ZAK0.83555512
96TYRO30.82073766
97PKN10.81551284
98FGFR20.81154114
99TBK10.80724740
100DYRK30.80092943
101MUSK0.78939962
102HCK0.78674409
103TXK0.78508467
104FGFR10.78452914
105IKBKE0.77703763
106CAMK2B0.77331261
107DDR20.77239222
108PAK30.76840357
109CHEK20.75684602
110MARK20.75357042
111NLK0.75172681
112CDK40.74514054
113STK160.73784361
114PAK60.73728808
115TRPM70.72928000
116ARAF0.72887496
117CLK10.71894790
118ILK0.70976782
119CAMK2A0.69348220
120MAP2K10.66204237
121CAMK2D0.65483935
122MAPK70.64340404
123ALK0.64327470
124CDK70.62685833
125PRKCE0.62678796
126STK30.61806818
127AKT30.61182489
128PTK2B0.60475501
129MAP3K30.60012808
130JAK10.59922406
131STK110.59379957
132AURKA0.58696871
133ACVR1B0.58633418
134PBK0.57495042
135PRKCB0.56529546
136ABL10.55024042
137IGF1R0.54515778
138PRKD10.53970366
139ADRBK10.52540056
140CSF1R0.52207387
141SRC0.50771339
142RAF10.50699923
143NTRK30.50585670
144MAPK80.49571983
145CDK150.49372512
146RPS6KA10.48321826
147CSNK1G30.48087325
148BTK0.48055612
149TLK10.47824621
150MAP3K100.47761769
151CDC42BPA0.47652963
152CDK11A0.46584436
153RPS6KB20.46556176
154CSNK1G10.46023722
155CDK50.45899721
156TGFBR20.45845938
157CAMK1G0.45832040
158ABL20.45642123
159NEK90.45430810
160FLT30.45046559
161PRKG20.44308781
162EIF2AK10.44120505
163SIK10.43133756
164CDK180.42907468
165TAOK30.42825291
166CDK20.39834573
167PLK10.39189280
168CDK10.38884107
169BUB10.35531903
170PAK10.35406611

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041224.09701000
2TGF-beta signaling pathway_Homo sapiens_hsa043503.44003114
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.25029655
4Fructose and mannose metabolism_Homo sapiens_hsa000512.73786241
5Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.65677988
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.40539132
7Base excision repair_Homo sapiens_hsa034102.17314274
8ECM-receptor interaction_Homo sapiens_hsa045122.10569546
9Cell adhesion molecules (CAMs)_Homo sapiens_hsa045142.10045659
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.05867235
11Other glycan degradation_Homo sapiens_hsa005112.02646862
12Fanconi anemia pathway_Homo sapiens_hsa034602.00154440
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.92220368
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.86157572
15T cell receptor signaling pathway_Homo sapiens_hsa046601.85863041
16Axon guidance_Homo sapiens_hsa043601.79053487
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.77777022
18Shigellosis_Homo sapiens_hsa051311.77200233
19Platelet activation_Homo sapiens_hsa046111.76658790
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.72633538
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.72093001
22Primary immunodeficiency_Homo sapiens_hsa053401.70629973
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66498190
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.66428450
25Pyrimidine metabolism_Homo sapiens_hsa002401.63425793
26Proteoglycans in cancer_Homo sapiens_hsa052051.62481970
27Regulation of actin cytoskeleton_Homo sapiens_hsa048101.61486099
28Basal cell carcinoma_Homo sapiens_hsa052171.60564214
29B cell receptor signaling pathway_Homo sapiens_hsa046621.56738814
30DNA replication_Homo sapiens_hsa030301.53605018
31Bladder cancer_Homo sapiens_hsa052191.53580488
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.50770610
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.49024470
34Renal cell carcinoma_Homo sapiens_hsa052111.47315450
35Dorso-ventral axis formation_Homo sapiens_hsa043201.43922317
36Chronic myeloid leukemia_Homo sapiens_hsa052201.43121134
37Cell cycle_Homo sapiens_hsa041101.34086318
38Small cell lung cancer_Homo sapiens_hsa052221.32967365
39Focal adhesion_Homo sapiens_hsa045101.31042825
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28749290
41Lysosome_Homo sapiens_hsa041421.27711513
42Non-homologous end-joining_Homo sapiens_hsa034501.25758913
43Hippo signaling pathway_Homo sapiens_hsa043901.24985049
44Ether lipid metabolism_Homo sapiens_hsa005651.24800220
45Inositol phosphate metabolism_Homo sapiens_hsa005621.23934895
46Long-term depression_Homo sapiens_hsa047301.23917028
47MicroRNAs in cancer_Homo sapiens_hsa052061.23106056
48Nitrogen metabolism_Homo sapiens_hsa009101.23062383
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22267540
50Glutamatergic synapse_Homo sapiens_hsa047241.21732031
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20997406
52Graft-versus-host disease_Homo sapiens_hsa053321.19706094
53Dilated cardiomyopathy_Homo sapiens_hsa054141.16781205
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15929305
55Viral myocarditis_Homo sapiens_hsa054161.15246551
56Rap1 signaling pathway_Homo sapiens_hsa040151.14201118
57Nicotine addiction_Homo sapiens_hsa050331.13716109
58ErbB signaling pathway_Homo sapiens_hsa040121.13104602
59Hematopoietic cell lineage_Homo sapiens_hsa046401.12774360
60Colorectal cancer_Homo sapiens_hsa052101.11724735
61Pancreatic cancer_Homo sapiens_hsa052121.11421839
62Acute myeloid leukemia_Homo sapiens_hsa052211.11015130
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10043943
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09822085
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.08640318
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08531374
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07743843
68Hedgehog signaling pathway_Homo sapiens_hsa043401.07393038
69Lysine degradation_Homo sapiens_hsa003101.05909370
70Central carbon metabolism in cancer_Homo sapiens_hsa052301.02990912
71Leishmaniasis_Homo sapiens_hsa051401.00748905
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00445395
73Thyroid cancer_Homo sapiens_hsa052160.97957515
74Pathways in cancer_Homo sapiens_hsa052000.96114826
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93941371
76Toxoplasmosis_Homo sapiens_hsa051450.93181445
77Prostate cancer_Homo sapiens_hsa052150.93057222
78Adherens junction_Homo sapiens_hsa045200.90453095
79VEGF signaling pathway_Homo sapiens_hsa043700.89533390
80Wnt signaling pathway_Homo sapiens_hsa043100.88659906
81Glioma_Homo sapiens_hsa052140.88361111
82Mismatch repair_Homo sapiens_hsa034300.88257862
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87644927
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86922591
85Osteoclast differentiation_Homo sapiens_hsa043800.86075433
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85562723
87Endometrial cancer_Homo sapiens_hsa052130.85340108
88Measles_Homo sapiens_hsa051620.85144262
89Oxytocin signaling pathway_Homo sapiens_hsa049210.84593755
90cAMP signaling pathway_Homo sapiens_hsa040240.84401521
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83424561
92Melanogenesis_Homo sapiens_hsa049160.83381160
93Cocaine addiction_Homo sapiens_hsa050300.82907152
94Homologous recombination_Homo sapiens_hsa034400.82803345
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82330340
96Long-term potentiation_Homo sapiens_hsa047200.80453927
97Salivary secretion_Homo sapiens_hsa049700.79384327
98Hepatitis B_Homo sapiens_hsa051610.78884879
99Gap junction_Homo sapiens_hsa045400.77958483
100Endocytosis_Homo sapiens_hsa041440.76174968
101GnRH signaling pathway_Homo sapiens_hsa049120.75990735
102mTOR signaling pathway_Homo sapiens_hsa041500.75691257
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75140061
104MAPK signaling pathway_Homo sapiens_hsa040100.73936728
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.73221015
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.72882441
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72835471
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72798837
109Estrogen signaling pathway_Homo sapiens_hsa049150.72208787
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71339722
111Ras signaling pathway_Homo sapiens_hsa040140.70082189
112Non-small cell lung cancer_Homo sapiens_hsa052230.69293931
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69262357
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69015885
115Gastric acid secretion_Homo sapiens_hsa049710.68083291
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.67727642
117TNF signaling pathway_Homo sapiens_hsa046680.67265356
118Malaria_Homo sapiens_hsa051440.67083439
119Renin secretion_Homo sapiens_hsa049240.66975593
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.65705547
121Apoptosis_Homo sapiens_hsa042100.65195501
122Biosynthesis of amino acids_Homo sapiens_hsa012300.64081944
123Salmonella infection_Homo sapiens_hsa051320.63860657
124Steroid biosynthesis_Homo sapiens_hsa001000.63481174
125Serotonergic synapse_Homo sapiens_hsa047260.62553409
126Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62305821
127Notch signaling pathway_Homo sapiens_hsa043300.59261611
128Choline metabolism in cancer_Homo sapiens_hsa052310.58453556
129Sphingolipid metabolism_Homo sapiens_hsa006000.57007901
130Morphine addiction_Homo sapiens_hsa050320.56865768
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55959327
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55802008
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55755226
134Circadian rhythm_Homo sapiens_hsa047100.55629827
135HTLV-I infection_Homo sapiens_hsa051660.55391092
136One carbon pool by folate_Homo sapiens_hsa006700.55372578
137RNA transport_Homo sapiens_hsa030130.55225826
138Antigen processing and presentation_Homo sapiens_hsa046120.54502927
139Viral carcinogenesis_Homo sapiens_hsa052030.52767765
140GABAergic synapse_Homo sapiens_hsa047270.52592289
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52508852
142Insulin resistance_Homo sapiens_hsa049310.50964932
143Cholinergic synapse_Homo sapiens_hsa047250.50385517
144Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50222985
1452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49859040
146Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49092160
147Chemokine signaling pathway_Homo sapiens_hsa040620.48885317
148Amoebiasis_Homo sapiens_hsa051460.48730723
149RNA polymerase_Homo sapiens_hsa030200.48265899
150Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46950965
151Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46671405
152N-Glycan biosynthesis_Homo sapiens_hsa005100.46356107
153Calcium signaling pathway_Homo sapiens_hsa040200.45983747
154Melanoma_Homo sapiens_hsa052180.42486626
155Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41549193
156Hepatitis C_Homo sapiens_hsa051600.40974583
157Pentose phosphate pathway_Homo sapiens_hsa000300.40617974
158Ovarian steroidogenesis_Homo sapiens_hsa049130.40297572
159AMPK signaling pathway_Homo sapiens_hsa041520.40197650
160Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39655558
161Adipocytokine signaling pathway_Homo sapiens_hsa049200.38654840
162Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37217989
163RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34947036
164Insulin signaling pathway_Homo sapiens_hsa049100.34706803

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