QPRT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.65215169
2L-phenylalanine catabolic process (GO:0006559)7.65215169
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.39122407
4L-phenylalanine metabolic process (GO:0006558)7.39122407
5aromatic amino acid family catabolic process (GO:0009074)6.97811304
6indole-containing compound catabolic process (GO:0042436)6.38684936
7indolalkylamine catabolic process (GO:0046218)6.38684936
8tryptophan catabolic process (GO:0006569)6.38684936
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.34341807
10kynurenine metabolic process (GO:0070189)6.18138405
11glyoxylate metabolic process (GO:0046487)6.12255333
12tryptophan metabolic process (GO:0006568)5.99917083
13bile acid biosynthetic process (GO:0006699)5.95249524
14urea cycle (GO:0000050)5.68607569
15urea metabolic process (GO:0019627)5.68607569
16negative regulation of fibrinolysis (GO:0051918)5.65873340
17high-density lipoprotein particle remodeling (GO:0034375)5.60916319
18cysteine metabolic process (GO:0006534)5.50870870
19alpha-linolenic acid metabolic process (GO:0036109)5.49951232
20regulation of fibrinolysis (GO:0051917)5.46148692
21sulfur amino acid catabolic process (GO:0000098)5.37847260
22serine family amino acid catabolic process (GO:0009071)5.34285521
23protein carboxylation (GO:0018214)5.30314506
24peptidyl-glutamic acid carboxylation (GO:0017187)5.30314506
25regulation of protein activation cascade (GO:2000257)5.30204292
26complement activation, alternative pathway (GO:0006957)5.26266881
27nitrogen cycle metabolic process (GO:0071941)5.25039897
28aromatic amino acid family metabolic process (GO:0009072)5.08948488
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.02959923
30bile acid metabolic process (GO:0008206)5.02600758
31regulation of complement activation (GO:0030449)4.94220126
32regulation of cholesterol esterification (GO:0010872)4.92598074
33reverse cholesterol transport (GO:0043691)4.92121924
34regulation of triglyceride catabolic process (GO:0010896)4.90529203
35homocysteine metabolic process (GO:0050667)4.89208170
36lysine metabolic process (GO:0006553)4.85369543
37lysine catabolic process (GO:0006554)4.85369543
38protein-lipid complex remodeling (GO:0034368)4.80486020
39macromolecular complex remodeling (GO:0034367)4.80486020
40plasma lipoprotein particle remodeling (GO:0034369)4.80486020
41tyrosine metabolic process (GO:0006570)4.78746245
42alpha-amino acid catabolic process (GO:1901606)4.74738125
43amino-acid betaine metabolic process (GO:0006577)4.73887900
44phospholipid efflux (GO:0033700)4.65337824
45glycine metabolic process (GO:0006544)4.62257912
46triglyceride homeostasis (GO:0070328)4.61316053
47acylglycerol homeostasis (GO:0055090)4.61316053
48negative regulation of cholesterol transport (GO:0032375)4.61274417
49negative regulation of sterol transport (GO:0032372)4.61274417
50L-serine metabolic process (GO:0006563)4.56612292
51indolalkylamine metabolic process (GO:0006586)4.51498072
52cellular ketone body metabolic process (GO:0046950)4.44426691
53amine catabolic process (GO:0009310)4.43406074
54cellular biogenic amine catabolic process (GO:0042402)4.43406074
55serine family amino acid metabolic process (GO:0009069)4.43343850
56imidazole-containing compound metabolic process (GO:0052803)4.39637820
57coenzyme catabolic process (GO:0009109)4.39516712
58plasma lipoprotein particle clearance (GO:0034381)4.38930637
59cellular amino acid catabolic process (GO:0009063)4.37063335
60bile acid and bile salt transport (GO:0015721)4.29678143
61glutamate metabolic process (GO:0006536)4.29222312
62serine family amino acid biosynthetic process (GO:0009070)4.27779301
63cholesterol efflux (GO:0033344)4.22774484
64benzene-containing compound metabolic process (GO:0042537)4.19158601
65cellular modified amino acid catabolic process (GO:0042219)4.18092024
66aldehyde catabolic process (GO:0046185)4.15601706
67cellular glucuronidation (GO:0052695)4.15112301
68arginine metabolic process (GO:0006525)4.09534186
69ethanol oxidation (GO:0006069)4.08097093
70dicarboxylic acid biosynthetic process (GO:0043650)4.07707317
71plasma lipoprotein particle assembly (GO:0034377)4.05635191
72drug catabolic process (GO:0042737)4.03773557
73fibrinolysis (GO:0042730)4.00599730
74blood coagulation, intrinsic pathway (GO:0007597)3.93993967
75positive regulation of lipoprotein lipase activity (GO:0051006)3.92390032
76positive regulation of triglyceride lipase activity (GO:0061365)3.92390032
77low-density lipoprotein particle remodeling (GO:0034374)3.88669173
78ketone body metabolic process (GO:1902224)3.83894352
79cofactor catabolic process (GO:0051187)3.80729559
80* carboxylic acid catabolic process (GO:0046395)3.78543821
81* organic acid catabolic process (GO:0016054)3.78543821
82short-chain fatty acid metabolic process (GO:0046459)3.75736368
83regulation of posttranscriptional gene silencing (GO:0060147)3.74576722
84regulation of gene silencing by miRNA (GO:0060964)3.74576722
85regulation of gene silencing by RNA (GO:0060966)3.74576722
86cholesterol homeostasis (GO:0042632)3.73312158
87cytolysis (GO:0019835)3.73293474
88acetyl-CoA metabolic process (GO:0006084)3.72614758
89complement activation, classical pathway (GO:0006958)3.71832705
90negative regulation of lipase activity (GO:0060192)3.71207027
91very-low-density lipoprotein particle assembly (GO:0034379)3.70537355
92uronic acid metabolic process (GO:0006063)3.69462264
93glucuronate metabolic process (GO:0019585)3.69462264
94phospholipid homeostasis (GO:0055091)3.68893272
95intestinal cholesterol absorption (GO:0030299)3.68774752
96urate metabolic process (GO:0046415)3.68611064
97protein activation cascade (GO:0072376)3.68206518
98positive regulation of lipid catabolic process (GO:0050996)3.67310746
99sterol homeostasis (GO:0055092)3.67297622
100complement activation (GO:0006956)3.65727568
101drug transmembrane transport (GO:0006855)3.65609659
102plasma lipoprotein particle organization (GO:0071827)3.65318987
103proline metabolic process (GO:0006560)3.64657109
104regulation of bile acid biosynthetic process (GO:0070857)3.60992448
105protein-lipid complex assembly (GO:0065005)3.60326244
106aspartate family amino acid catabolic process (GO:0009068)3.59610677
107viral transcription (GO:0019083)3.59400808
108ribosomal small subunit assembly (GO:0000028)3.53214411
109translational termination (GO:0006415)3.50300847
110exogenous drug catabolic process (GO:0042738)3.23835635
111ribosomal small subunit biogenesis (GO:0042274)3.16474846
112proline biosynthetic process (GO:0006561)3.14121538
113biotin metabolic process (GO:0006768)3.04239917
114SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.99236931
115protein-lipid complex subunit organization (GO:0071825)2.95318378
116paraxial mesoderm development (GO:0048339)2.95312012
117cotranslational protein targeting to membrane (GO:0006613)2.93503310
118translational elongation (GO:0006414)2.91628658
119protein targeting to ER (GO:0045047)2.91003030
120epoxygenase P450 pathway (GO:0019373)2.89816240
121heme transport (GO:0015886)2.84383121
122maturation of SSU-rRNA (GO:0030490)2.83575552
123cholesterol biosynthetic process (GO:0006695)2.80736549
124mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.79085563
125nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.78900800
126establishment of protein localization to endoplasmic reticulum (GO:0072599)2.77759451
127protein localization to endoplasmic reticulum (GO:0070972)2.73460898
128tetrahydrofolate metabolic process (GO:0046653)2.71796382
129positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.69690900
130regulation of plasminogen activation (GO:0010755)2.69585415
131heterochromatin organization (GO:0070828)2.69284403
132regulation of lipoprotein particle clearance (GO:0010984)2.68330732
133regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.67446115
134L-ascorbic acid metabolic process (GO:0019852)2.67080936
135regulation of cholesterol biosynthetic process (GO:0045540)2.66853544
136oxidative demethylation (GO:0070989)2.65907192
137regulation of apoptotic cell clearance (GO:2000425)2.64185984
138regulation of mitochondrial translation (GO:0070129)2.63784100

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.49186458
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.32151723
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.19154122
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.46951893
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.34447655
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.27594079
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.89992086
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.22168811
9E2F7_22180533_ChIP-Seq_HELA_Human4.21157791
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.95432359
11MYC_18555785_ChIP-Seq_MESCs_Mouse3.64352917
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.71892754
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.54150441
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.49556734
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44289759
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.43269545
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.28815760
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26481611
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.20016002
20* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.09671914
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.07457646
22* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07426658
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07325267
24XRN2_22483619_ChIP-Seq_HELA_Human2.05703149
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.02108931
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00336327
27* ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.1878046
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94482412
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90408524
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.86023120
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.84946220
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82733750
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79283982
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79269308
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.76590547
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.71798569
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.69435026
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.61954382
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.61800257
40TTF2_22483619_ChIP-Seq_HELA_Human1.58399090
41FOXA2_19822575_ChIP-Seq_HepG2_Human1.51024844
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50644462
43KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.50079032
44KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.50079032
45KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.50079032
46GATA1_22025678_ChIP-Seq_K562_Human1.49840571
47HTT_18923047_ChIP-ChIP_STHdh_Human1.49233932
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48739679
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.47716123
50NANOG_16153702_ChIP-ChIP_HESCs_Human1.46851925
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46337016
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.46178244
53SOX2_16153702_ChIP-ChIP_HESCs_Human1.44665004
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43789138
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43076633
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.43008414
57* HNF4A_19822575_ChIP-Seq_HepG2_Human1.42449252
58CLOCK_20551151_ChIP-Seq_293T_Human1.42079789
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40486923
60GABP_19822575_ChIP-Seq_HepG2_Human1.35668240
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.35477319
62* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35417679
63* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34240619
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33761946
65AR_21909140_ChIP-Seq_LNCAP_Human1.32280494
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30728807
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27828169
68TCF3_18692474_ChIP-Seq_MEFs_Mouse1.26990824
69RXRA_24833708_ChIP-Seq_LIVER_Mouse1.25779030
70FOXP3_21729870_ChIP-Seq_TREG_Human1.23675781
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23374957
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22235984
73NANOG_21062744_ChIP-ChIP_HESCs_Human1.21914976
74POU5F1_16518401_ChIP-PET_MESCs_Mouse1.21665810
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18127042
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18072311
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.18068861
78SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17639207
79* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.16247153
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15929814
81MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15494998
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.13289720
83NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12838783
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12347865
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10654242
86DCP1A_22483619_ChIP-Seq_HELA_Human1.06300195
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05715657
88ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05177700
89IRF8_22096565_ChIP-ChIP_GC-B_Human1.03502547
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03417886
91* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02915313
92FOXP1_21924763_ChIP-Seq_HESCs_Human1.02674451
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02399146
94KDM5A_27292631_Chip-Seq_BREAST_Human0.96874023
95* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.96014093
96* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.95992874
97KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95380315
98SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95161014
99TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93213924
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92934501
101SOX17_20123909_ChIP-Seq_XEN_Mouse0.92553315
102CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91327277
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89373126
104CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86474335
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.86371436
106SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84440449
107KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84380943
108PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81527915
109ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81038856
110AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80919243
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79949291
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.79462729
113RARG_19884340_ChIP-ChIP_MEFs_Mouse0.78148955
114GATA4_25053715_ChIP-Seq_YYC3_Human0.78070907
115* RARA_24833708_ChIP-Seq_LIVER_Mouse0.76073945
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.75986735
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.75045692
118STAT3_1855785_ChIP-Seq_MESCs_Mouse0.73087760
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.69993577
120RARB_24833708_ChIP-Seq_LIVER_Mouse0.68606366
121BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.68117932
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.67541007
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.64412461
124SALL4_18804426_ChIP-ChIP_XEN_Mouse0.63940873
125* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63463153
126CEBPB_22108803_ChIP-Seq_LS180_Human0.60106542
127ZNF263_19887448_ChIP-Seq_K562_Human0.60029142
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.58878588
129Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.57676826
130AR_20517297_ChIP-Seq_VCAP_Human0.57596265
131AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.56479008
132EGR1_19032775_ChIP-ChIP_M12_Human0.54829787
133E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.53213434
134ESR2_21235772_ChIP-Seq_MCF-7_Human0.53099435
135MYC_19915707_ChIP-ChIP_AK7_Human0.52972993
136LXR_22292898_ChIP-Seq_THP-1_Human0.52684207
137FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51480979
138GATA1_19941827_ChIP-Seq_MEL_Mouse0.49487098
139ESET_19884257_ChIP-Seq_ESCs_Mouse0.48623822
140IRF1_19129219_ChIP-ChIP_H3396_Human0.46618955
141PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.45971531
142FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.45940178
143FOXA1_25552417_ChIP-Seq_VCAP_Human0.45864843
144STAT1_17558387_ChIP-Seq_HELA_Human0.45306628
145P53_21459846_ChIP-Seq_SAOS-2_Human0.45140971
146TAF2_19829295_ChIP-Seq_ESCs_Human0.44962058
147ESR1_21235772_ChIP-Seq_MCF-7_Human0.44382754
148PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44088823
149PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.44041015
150PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43091627
151CBP_21632823_ChIP-Seq_H3396_Human0.42143505
152NRF2_20460467_ChIP-Seq_MEFs_Mouse0.41287219
153NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.41287219
154GATA6_25053715_ChIP-Seq_YYC3_Human0.41217273
155CDX2_20551321_ChIP-Seq_CACO-2_Human0.41184243
156GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.41052368
157FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40835366
158SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40699748
159CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.40219150
160STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38962375
161TET1_21451524_ChIP-Seq_MESCs_Mouse0.38077344
162GATA1_19941826_ChIP-Seq_K562_Human0.38028530
163GATA2_19941826_ChIP-Seq_K562_Human0.37119507
164* SPI1_26923725_Chip-Seq_HPCs_Mouse0.36040076
165PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.35497186
166ERG_20517297_ChIP-Seq_VCAP_Human0.35366713
167CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.34731575
168FOXH1_21741376_ChIP-Seq_EPCs_Human0.34347661
169NCOR_22424771_ChIP-Seq_293T_Human0.34272858
170SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.33418064
171BCOR_27268052_Chip-Seq_Bcells_Human0.32998878
172SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.32985792
173CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.32960749
174OCT4_20526341_ChIP-Seq_ESCs_Human0.32748650
175MYC_27129775_Chip-Seq_CORNEA_Mouse0.32606621
176* SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.32499534
177RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.32304276

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.28967798
2MP0005360_urolithiasis7.70628414
3MP0005085_abnormal_gallbladder_physiolo6.37239326
4MP0005365_abnormal_bile_salt6.17703778
5MP0008875_abnormal_xenobiotic_pharmacok4.96396248
6MP0003806_abnormal_nucleotide_metabolis4.33696168
7MP0003252_abnormal_bile_duct3.87617969
8MP0003136_yellow_coat_color3.67506441
9MP0010329_abnormal_lipoprotein_level3.51563475
10MP0009840_abnormal_foam_cell3.24380202
11MP0003122_maternal_imprinting3.01625493
12MP0005083_abnormal_biliary_tract2.93013963
13MP0005332_abnormal_amino_acid2.92780554
14MP0003195_calcinosis2.85311974
15MP0006292_abnormal_olfactory_placode2.69388157
16MP0001666_abnormal_nutrient_absorption2.55191045
17MP0003191_abnormal_cellular_cholesterol2.48397365
18MP0000566_synostosis2.45030895
19MP0002938_white_spotting2.43581027
20MP0004019_abnormal_vitamin_homeostasis2.35828094
21MP0005377_hearing/vestibular/ear_phenot2.35131683
22MP0003878_abnormal_ear_physiology2.35131683
23MP0003941_abnormal_skin_development2.24813957
24MP0010030_abnormal_orbit_morphology2.18458239
25MP0000609_abnormal_liver_physiology2.14373762
26MP0002138_abnormal_hepatobiliary_system2.10081447
27MP0003567_abnormal_fetal_cardiomyocyte2.09548572
28MP0002118_abnormal_lipid_homeostasis2.03894454
29MP0003868_abnormal_feces_composition1.87571645
30MP0005319_abnormal_enzyme/_coenzyme1.86264726
31MP0001293_anophthalmia1.82300979
32MP0001764_abnormal_homeostasis1.79382123
33MP0003123_paternal_imprinting1.74018225
34MP0003890_abnormal_embryonic-extraembry1.69455586
35MP0003693_abnormal_embryo_hatching1.66928528
36MP0000372_irregular_coat_pigmentation1.64106839
37MP0009697_abnormal_copulation1.62784322
38MP0005584_abnormal_enzyme/coenzyme_acti1.59993681
39MP0002089_abnormal_postnatal_growth/wei1.55562294
40MP0002697_abnormal_eye_size1.55144544
41MP0009379_abnormal_foot_pigmentation1.54909865
42MP0004264_abnormal_extraembryonic_tissu1.50492085
43MP0003011_delayed_dark_adaptation1.47710513
44MP0004957_abnormal_blastocyst_morpholog1.47524111
45MP0005451_abnormal_body_composition1.47210467
46MP0003937_abnormal_limbs/digits/tail_de1.43168520
47MP0003186_abnormal_redox_activity1.42262682
48MP0009643_abnormal_urine_homeostasis1.38812785
49MP0003111_abnormal_nucleus_morphology1.34019438
50MP0008932_abnormal_embryonic_tissue1.33295678
51MP0003942_abnormal_urinary_system1.33128543
52MP0003656_abnormal_erythrocyte_physiolo1.32880653
53MP0004133_heterotaxia1.32028674
54MP0000598_abnormal_liver_morphology1.20908486
55MP0003119_abnormal_digestive_system1.19024297
56MP0002249_abnormal_larynx_morphology1.14596564
57MP0005647_abnormal_sex_gland1.12465990
58MP0003938_abnormal_ear_development1.11658880
59MP0003121_genomic_imprinting1.11407849
60MP0005636_abnormal_mineral_homeostasis1.08416893
61MP0009764_decreased_sensitivity_to1.07538431
62MP0002233_abnormal_nose_morphology1.04492113
63MP0003385_abnormal_body_wall1.03651003
64MP0009763_increased_sensitivity_to1.03334213
65MP0010094_abnormal_chromosome_stability1.03298387
66MP0001286_abnormal_eye_development1.01794660
67MP0002111_abnormal_tail_morphology1.01314520
68MP0000049_abnormal_middle_ear1.00880388
69MP0001324_abnormal_eye_pigmentation1.00534289
70MP0001730_embryonic_growth_arrest0.96681653
71MP0003705_abnormal_hypodermis_morpholog0.96644806
72MP0000604_amyloidosis0.96595519
73MP0004272_abnormal_basement_membrane0.95476379
74MP0008469_abnormal_protein_level0.95164914
75MP0010368_abnormal_lymphatic_system0.92047731
76MP0006036_abnormal_mitochondrial_physio0.91881271
77MP0002092_abnormal_eye_morphology0.91701063
78MP0005171_absent_coat_pigmentation0.91634631
79MP0009642_abnormal_blood_homeostasis0.89697658
80MP0002254_reproductive_system_inflammat0.88656435
81MP0003077_abnormal_cell_cycle0.88036115
82MP0002085_abnormal_embryonic_tissue0.87555456
83MP0002084_abnormal_developmental_patter0.87489680
84MP0000428_abnormal_craniofacial_morphol0.87307104
85MP0003315_abnormal_perineum_morphology0.86931537
86MP0001697_abnormal_embryo_size0.85168629
87MP0003283_abnormal_digestive_organ0.85138652
88MP0005670_abnormal_white_adipose0.84187833
89MP0001672_abnormal_embryogenesis/_devel0.83473348
90MP0005380_embryogenesis_phenotype0.83473348
91MP0005084_abnormal_gallbladder_morpholo0.83026430
92MP0005376_homeostasis/metabolism_phenot0.82806356
93MP0005408_hypopigmentation0.81632769
94MP0009384_cardiac_valve_regurgitation0.81123746
95MP0009765_abnormal_xenobiotic_induced0.81003173
96MP0002876_abnormal_thyroid_physiology0.80776346
97MP0000371_diluted_coat_color0.80705803
98MP0001529_abnormal_vocalization0.76412393
99MP0003984_embryonic_growth_retardation0.76110518
100MP0002088_abnormal_embryonic_growth/wei0.75252340
101MP0002078_abnormal_glucose_homeostasis0.72972804
102MP0001346_abnormal_lacrimal_gland0.72842325
103MP0005220_abnormal_exocrine_pancreas0.70258958
104MP0001756_abnormal_urination0.68620634
105MP0005266_abnormal_metabolism0.67644002
106MP0005257_abnormal_intraocular_pressure0.67577430
107MP0000537_abnormal_urethra_morphology0.66600689
108MP0003115_abnormal_respiratory_system0.65712383
109MP0002971_abnormal_brown_adipose0.65552519
110MP0002090_abnormal_vision0.65316537
111MP0003861_abnormal_nervous_system0.64907051
112MP0005334_abnormal_fat_pad0.64714957
113MP0009703_decreased_birth_body0.64696664
114MP0009053_abnormal_anal_canal0.64637277
115MP0005535_abnormal_body_temperature0.64194218
116MP0001661_extended_life_span0.63852034
117MP0000631_abnormal_neuroendocrine_gland0.62106870
118MP0002075_abnormal_coat/hair_pigmentati0.61988766
119MP0006035_abnormal_mitochondrial_morpho0.60485930
120MP0008058_abnormal_DNA_repair0.59648317
121MP0002080_prenatal_lethality0.59596256
122MP0002136_abnormal_kidney_physiology0.59089784
123MP0005464_abnormal_platelet_physiology0.57793859
124MP0003718_maternal_effect0.56138355
125MP0004130_abnormal_muscle_cell0.55864889
126MP0003724_increased_susceptibility_to0.54699846
127MP0000639_abnormal_adrenal_gland0.53496276
128MP0003690_abnormal_glial_cell0.53301452
129MP0005395_other_phenotype0.52596770
130MP0003436_decreased_susceptibility_to0.49408221
131MP0005448_abnormal_energy_balance0.48988653
132MP0002928_abnormal_bile_duct0.47281953
133MP0003638_abnormal_response/metabolism_0.46900396
134MP0008873_increased_physiological_sensi0.46001837
135MP0003329_amyloid_beta_deposits0.45608590
136MP0004381_abnormal_hair_follicle0.45447470
137MP0002822_catalepsy0.43193267
138MP0009672_abnormal_birth_weight0.40142550
139MP0008874_decreased_physiological_sensi0.38945350
140MP0004782_abnormal_surfactant_physiolog0.38699423
141MP0003953_abnormal_hormone_level0.38501691
142MP0008872_abnormal_physiological_respon0.38029282
143MP0003075_altered_response_to0.36990822
144MP0005166_decreased_susceptibility_to0.36653164
145MP0002132_abnormal_respiratory_system0.35533429
146MP0001853_heart_inflammation0.35138567
147MP0001845_abnormal_inflammatory_respons0.34111215
148MP0005666_abnormal_adipose_tissue0.33672208
149MP0002796_impaired_skin_barrier0.33157026
150MP0006082_CNS_inflammation0.33116159
151MP0004147_increased_porphyrin_level0.31372120
152MP0009115_abnormal_fat_cell0.31360389
153MP0004883_abnormal_blood_vessel0.31078427
154MP0000230_abnormal_systemic_arterial0.30764268
155MP0004043_abnormal_pH_regulation0.30581018
156MP0000249_abnormal_blood_vessel0.30505497
157MP0002168_other_aberrant_phenotype0.29985200
158MP0002970_abnormal_white_adipose0.29506447
159MP0001243_abnormal_dermal_layer0.29355455
160MP0005248_abnormal_Harderian_gland0.29189449
161MP0002135_abnormal_kidney_morphology0.29119860
162MP0000579_abnormal_nail_morphology0.26020153
163MP0001765_abnormal_ion_homeostasis0.25978889
164MP0005058_abnormal_lysosome_morphology0.25607341
165MP0005075_abnormal_melanosome_morpholog0.25091084

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.41240825
2Intrahepatic cholestasis (HP:0001406)7.18155190
3Deep venous thrombosis (HP:0002625)7.14803716
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.66848902
5Prolonged partial thromboplastin time (HP:0003645)6.42762796
6Hypobetalipoproteinemia (HP:0003563)6.22545491
7Xanthomatosis (HP:0000991)6.17429995
8Hyperlipoproteinemia (HP:0010980)5.38071926
9Complement deficiency (HP:0004431)5.28730185
10Joint hemorrhage (HP:0005261)4.85115921
11Hyperammonemia (HP:0001987)4.68220087
12Hypolipoproteinemia (HP:0010981)4.66384915
13Hyperglycinemia (HP:0002154)4.56011880
14Ketosis (HP:0001946)4.34621407
15Abnormality of the common coagulation pathway (HP:0010990)4.34303425
16Abnormality of glutamine family amino acid metabolism (HP:0010902)4.33409627
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.32480313
18Epidermoid cyst (HP:0200040)4.30330252
19Abnormality of methionine metabolism (HP:0010901)4.29421336
20Abnormality of aspartate family amino acid metabolism (HP:0010899)4.27413070
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.25169262
22Hyperglycinuria (HP:0003108)4.18082225
23Abnormality of pyrimidine metabolism (HP:0004353)4.13559244
24Abnormality of glycine metabolism (HP:0010895)4.08733105
25Abnormality of serine family amino acid metabolism (HP:0010894)4.08733105
26Hypoalphalipoproteinemia (HP:0003233)4.08725347
27Fat malabsorption (HP:0002630)4.03445937
28Hypoglycemic coma (HP:0001325)3.85511853
29Abnormality of complement system (HP:0005339)3.85165058
30Abnormality of the intrinsic pathway (HP:0010989)3.64658403
31Reticulocytopenia (HP:0001896)3.60104818
32Conjugated hyperbilirubinemia (HP:0002908)3.57711166
33Hypercholesterolemia (HP:0003124)3.50933392
34Abnormality of fatty-acid metabolism (HP:0004359)3.47895573
35Hyperbilirubinemia (HP:0002904)3.38741359
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.38023668
37Abnormality of nucleobase metabolism (HP:0010932)3.27999242
38Delayed CNS myelination (HP:0002188)3.24265298
39Abnormality of serum amino acid levels (HP:0003112)3.19284865
40Hypochromic microcytic anemia (HP:0004840)3.06765621
41Hepatocellular carcinoma (HP:0001402)3.05236504
42Steatorrhea (HP:0002570)3.05058005
43Ketoacidosis (HP:0001993)3.03894845
44Abnormality of cells of the erythroid lineage (HP:0012130)3.01208822
45Spontaneous abortion (HP:0005268)2.99684531
46Abnormal number of erythroid precursors (HP:0012131)2.91063800
47Metabolic acidosis (HP:0001942)2.88253575
48Abnormality of purine metabolism (HP:0004352)2.85219240
49Gout (HP:0001997)2.78338684
50Systemic lupus erythematosus (HP:0002725)2.77119672
51Lethargy (HP:0001254)2.73701504
52Myocardial infarction (HP:0001658)2.73586447
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.71189353
54Dicarboxylic aciduria (HP:0003215)2.71189353
55Bilateral microphthalmos (HP:0007633)2.69549376
56Partial duplication of thumb phalanx (HP:0009944)2.67028060
57Hepatoblastoma (HP:0002884)2.62089128
58Vascular calcification (HP:0004934)2.61258794
59Macrocytic anemia (HP:0001972)2.59024327
60Acanthocytosis (HP:0001927)2.54817650
61Skin nodule (HP:0200036)2.53966222
62Cerebral edema (HP:0002181)2.52820448
63Choanal stenosis (HP:0000452)2.50222682
64Broad alveolar ridges (HP:0000187)2.49377464
65Spastic diplegia (HP:0001264)2.47102219
66Hypoglycemic seizures (HP:0002173)2.44696302
67Septo-optic dysplasia (HP:0100842)2.42765155
68Neonatal onset (HP:0003623)2.42525097
69Abnormality of glycolysis (HP:0004366)2.38569796
70Irritability (HP:0000737)2.38555446
71Increased serum pyruvate (HP:0003542)2.38211152
72Recurrent gram-negative bacterial infections (HP:0005420)2.37433636
73Abnormal tarsal ossification (HP:0008369)2.36498921
74Abnormal gallbladder morphology (HP:0012437)2.36051615
75Generalized aminoaciduria (HP:0002909)2.33860005
76Glomerulonephritis (HP:0000099)2.33629862
77Osteomalacia (HP:0002749)2.32768080
78Vaginal fistula (HP:0004320)2.31720013
79Cholelithiasis (HP:0001081)2.31623104
80Cholecystitis (HP:0001082)2.30022720
81Abnormal gallbladder physiology (HP:0012438)2.30022720
82Abnormality of reticulocytes (HP:0004312)2.29949742
83Cardiovascular calcification (HP:0011915)2.29722425
84Mitral stenosis (HP:0001718)2.27993408
85Gingival bleeding (HP:0000225)2.26657926
86Malnutrition (HP:0004395)2.26512754
87Enlarged kidneys (HP:0000105)2.25529162
88Pancreatitis (HP:0001733)2.25009950
89Partial duplication of the phalanx of hand (HP:0009999)2.24611654
90Irregular epiphyses (HP:0010582)2.23574704
91Amyloidosis (HP:0011034)2.22506587
92Vomiting (HP:0002013)2.19660752
93Pancreatic islet-cell hyperplasia (HP:0004510)2.15850495
94Brushfield spots (HP:0001088)2.14560593
95Late onset (HP:0003584)2.14491625
96Thrombophlebitis (HP:0004418)2.13839080
97Menorrhagia (HP:0000132)2.13729301
98Sensorimotor neuropathy (HP:0007141)2.13223624
99Opisthotonus (HP:0002179)2.13063945
100Anophthalmia (HP:0000528)2.13017203
101Bifid tongue (HP:0010297)2.11979437
102Esophageal varix (HP:0002040)2.11234130
103Rickets (HP:0002748)2.09014383
104Proximal tubulopathy (HP:0000114)2.06543745
105Poikilocytosis (HP:0004447)2.05859063
106Alkalosis (HP:0001948)2.05270204
107Abnormality of the lacrimal duct (HP:0011481)2.04754779
108Absent epiphyses (HP:0010577)2.04498449
109Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.04498449
110Bicornuate uterus (HP:0000813)2.01944722
111Acute encephalopathy (HP:0006846)2.01343664
112Renal cortical cysts (HP:0000803)2.00462461
113Colon cancer (HP:0003003)1.99116804
114Hypophosphatemic rickets (HP:0004912)1.98266318
115Abnormality of iron homeostasis (HP:0011031)1.96970090
116Myelomeningocele (HP:0002475)1.95761169
117Abnormality of the gallbladder (HP:0005264)1.94698890
118Abnormality of transition element cation homeostasis (HP:0011030)1.93703239
119Duplication of thumb phalanx (HP:0009942)1.93327488
120Hyperuricemia (HP:0002149)1.93315946
121Increased purine levels (HP:0004368)1.93315946
122Hyperinsulinemic hypoglycemia (HP:0000825)1.91880032
123Hydroxyprolinuria (HP:0003080)1.91571509
124Abnormality of proline metabolism (HP:0010907)1.91571509
125Abnormal enzyme/coenzyme activity (HP:0012379)1.91515376
126Multiple enchondromatosis (HP:0005701)1.89276499
127Reduced antithrombin III activity (HP:0001976)1.88659235
128Hyperphosphaturia (HP:0003109)1.87676954
129Elevated hepatic transaminases (HP:0002910)1.87022290
130Glycosuria (HP:0003076)1.86615577
131Abnormality of urine glucose concentration (HP:0011016)1.86615577
132Abnormal cartilage morphology (HP:0002763)1.86365551
133Overlapping toe (HP:0001845)1.80478519
134Renal duplication (HP:0000075)1.80133855
135Vitreoretinal degeneration (HP:0000655)1.79535656
136Synostosis involving the elbow (HP:0003938)1.75705845
137Humeroradial synostosis (HP:0003041)1.75705845
138Abnormal lung lobation (HP:0002101)1.75657926
139Bifid scrotum (HP:0000048)1.75112742
140Birth length less than 3rd percentile (HP:0003561)1.74883349
141Meckel diverticulum (HP:0002245)1.74712613
142Hypoplasia of the capital femoral epiphysis (HP:0003090)1.74281243
143Diastasis recti (HP:0001540)1.73550425
144Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72134077
145Rib fusion (HP:0000902)1.69512848
146Reticulocytosis (HP:0001923)1.68297337
147Facial cleft (HP:0002006)1.68062519
148Abnormal urine phosphate concentration (HP:0012599)1.67420841
149Pallor (HP:0000980)1.65967779
150Abnormality of the nasolacrimal system (HP:0000614)1.64859337
151Abnormality of the ileum (HP:0001549)1.64608815
152Chromosomal breakage induced by crosslinking agents (HP:0003221)1.64529969
153Nephroblastoma (Wilms tumor) (HP:0002667)1.61895598
154Horseshoe kidney (HP:0000085)1.60032808
155Abnormality of the vitreous humor (HP:0004327)1.59233205
156Hemivertebrae (HP:0002937)1.58779484
157Coronal craniosynostosis (HP:0004440)1.55667830

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.76307414
2FGFR44.87551847
3ERN14.25673879
4SIK14.03860244
5VRK23.12677299
6TAOK33.04306310
7INSRR2.82304305
8ERBB42.79974665
9CDC72.79610855
10TTK2.47819806
11ZAK2.42941344
12NME12.38977706
13PLK42.30557347
14MAP2K42.25456952
15EEF2K2.10325421
16MAPK112.04347223
17FLT32.03714549
18BUB12.02157947
19TYRO32.00504621
20WNK41.86557936
21TYK21.86467528
22MST1R1.84370992
23PKN21.82844023
24NEK21.75813319
25WEE11.73709583
26PIK3CG1.62972217
27DYRK21.59440662
28MAP2K31.59235560
29RPS6KB21.57763095
30CDK191.53780257
31ABL21.52155364
32FGFR11.50671732
33NEK91.46231416
34NEK11.43095211
35PTK61.40212692
36KDR1.39258474
37VRK11.38779418
38CHEK21.38761245
39GRK61.36825463
40PINK11.35238108
41SRPK11.32999825
42PASK1.29832826
43CDK71.27998174
44LATS11.23917972
45TLK11.22518271
46SMG11.21781805
47MAP3K111.21458901
48STK38L1.21207601
49JAK21.21073502
50TIE11.21023019
51TAF11.20709912
52MAP3K141.18973625
53CDK121.17925313
54PLK11.16139718
55DAPK21.15618472
56PLK31.15230891
57MAP3K71.08973630
58IRAK31.08035325
59MKNK11.06126551
60TNIK1.05913845
61MAP3K31.05522139
62PRKAA21.04826231
63TBK11.04122668
64FGFR21.03854914
65TRIB31.02421914
66CAMK1G0.99946450
67ERBB20.98721188
68MAPK40.98312561
69FRK0.98124902
70MAPK150.97739884
71ATR0.96311046
72PIK3CA0.95486046
73JAK10.93528562
74MAP3K100.92563227
75MAP2K60.87638978
76DDR20.87199594
77BRSK20.87086506
78DYRK30.86698844
79TAOK20.83761753
80CSNK1E0.82931297
81AURKB0.81186460
82PRKCZ0.79922108
83CHEK10.76297315
84MATK0.75603614
85MAPKAPK30.75335285
86CSNK2A10.74519247
87EPHA30.73039770
88PRKACG0.72050581
89MAPK120.71500058
90GSK3A0.71205696
91DYRK1B0.70987133
92STK160.70425001
93CDK60.69852615
94STK30.68749092
95BRSK10.68504533
96CDK10.68125219
97EPHB10.68030964
98IKBKE0.67775021
99EPHA40.67766833
100CSK0.67045071
101AKT20.66706633
102ATM0.66660147
103BMX0.66014348
104CSNK2A20.65937857
105NTRK30.65758788
106EPHA20.65225594
107CDK20.64036130
108CAMK2G0.63860444
109ICK0.61176564
110SGK30.60548067
111TGFBR20.58391854
112PRKAA10.57760651
113FGFR30.57686434
114CDK40.55588496
115STK40.55072956
116AURKA0.54935545
117SGK20.53781476
118MAP4K10.51952551
119MAP3K50.51857615
120MET0.51754627
121TESK20.50680765
122MAPK70.50308692
123MKNK20.49818195
124PDK20.48945122
125PRKDC0.48789101
126CSF1R0.47670560
127DAPK30.46955697
128GRK10.45754581
129EIF2AK10.45711508
130CSNK1A10.44915265
131PRKCQ0.44904231
132CASK0.43485839
133PDGFRA0.43300237
134CAMK1D0.43248757
135MAPKAPK50.41159171
136CSNK1G10.39569636
137ALK0.39528629
138PTK20.39377441
139OXSR10.38884437
140SGK2230.38552877
141SGK4940.38552877
142AKT10.38358532
143GSK3B0.38138159
144PIM20.36309108
145KIT0.35860569
146CDK80.35738744
147IGF1R0.35731867
148WNK30.35395164
149MAP3K60.34461636
150CAMK40.34062224
151PDPK10.33146809
152PBK0.30216520
153IRAK10.29615548
154ACVR1B0.29579394
155NME20.29379296
156IRAK20.28098923
157MTOR0.28022338
158PRKCG0.27102289
159BTK0.26202886
160PKN10.26190774
161EGFR0.25984822
162ITK0.24895200
163MAP2K10.24598523
164ZAP700.23426764
165LATS20.22186981
166PRKCA0.20962887
167MAP2K20.20958329
168MAP3K130.20246224
169MAPK30.20209575
170PIM10.19147065

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.47852236
2Nitrogen metabolism_Homo sapiens_hsa009103.37487555
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.37417337
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34198724
5Arginine biosynthesis_Homo sapiens_hsa002203.04444665
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.74051558
7Complement and coagulation cascades_Homo sapiens_hsa046102.73476471
8Tryptophan metabolism_Homo sapiens_hsa003802.71406910
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.65085067
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.64124933
11Fatty acid degradation_Homo sapiens_hsa000712.50354679
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43352782
13Ribosome_Homo sapiens_hsa030102.33132114
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25843238
15Butanoate metabolism_Homo sapiens_hsa006502.17572918
16Peroxisome_Homo sapiens_hsa041462.15245242
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07716492
18Propanoate metabolism_Homo sapiens_hsa006401.97443034
19Histidine metabolism_Homo sapiens_hsa003401.90108981
20Chemical carcinogenesis_Homo sapiens_hsa052041.89507443
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86422130
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.84208771
23PPAR signaling pathway_Homo sapiens_hsa033201.83994691
24Fatty acid metabolism_Homo sapiens_hsa012121.79567529
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.75839868
26beta-Alanine metabolism_Homo sapiens_hsa004101.75080249
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74486688
28Staphylococcus aureus infection_Homo sapiens_hsa051501.70442822
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68399519
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67574946
31Retinol metabolism_Homo sapiens_hsa008301.64732967
32Caffeine metabolism_Homo sapiens_hsa002321.61973889
33Selenocompound metabolism_Homo sapiens_hsa004501.61919871
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61589014
35Phenylalanine metabolism_Homo sapiens_hsa003601.56411618
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50989761
37Pyruvate metabolism_Homo sapiens_hsa006201.43767805
38Bile secretion_Homo sapiens_hsa049761.43411973
39Tyrosine metabolism_Homo sapiens_hsa003501.42707544
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.41999683
41Fatty acid elongation_Homo sapiens_hsa000621.34253259
42DNA replication_Homo sapiens_hsa030301.33738304
43Folate biosynthesis_Homo sapiens_hsa007901.30470584
44Sulfur metabolism_Homo sapiens_hsa009201.29845750
45Mismatch repair_Homo sapiens_hsa034301.27524009
46Biosynthesis of amino acids_Homo sapiens_hsa012301.26956143
47Starch and sucrose metabolism_Homo sapiens_hsa005001.26339238
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.21641430
49Carbon metabolism_Homo sapiens_hsa012001.18767459
50Steroid biosynthesis_Homo sapiens_hsa001001.17275829
51ABC transporters_Homo sapiens_hsa020101.15268949
52Fat digestion and absorption_Homo sapiens_hsa049751.13581811
53Oxidative phosphorylation_Homo sapiens_hsa001901.11157035
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09409168
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07746190
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05435910
57Arginine and proline metabolism_Homo sapiens_hsa003301.03511904
58Sulfur relay system_Homo sapiens_hsa041221.03284672
59Vitamin B6 metabolism_Homo sapiens_hsa007500.98919704
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.98608149
61Homologous recombination_Homo sapiens_hsa034400.97653672
62Base excision repair_Homo sapiens_hsa034100.97412622
63Vitamin digestion and absorption_Homo sapiens_hsa049770.96604360
64One carbon pool by folate_Homo sapiens_hsa006700.94601627
65Parkinsons disease_Homo sapiens_hsa050120.93601896
66RNA polymerase_Homo sapiens_hsa030200.90301573
67Proteasome_Homo sapiens_hsa030500.87428636
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85840760
69Lysine degradation_Homo sapiens_hsa003100.85713133
70Other glycan degradation_Homo sapiens_hsa005110.78257132
71Glutathione metabolism_Homo sapiens_hsa004800.76058544
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74583939
73* Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74069052
74Spliceosome_Homo sapiens_hsa030400.71093965
75Basal cell carcinoma_Homo sapiens_hsa052170.70057337
76N-Glycan biosynthesis_Homo sapiens_hsa005100.67772512
77Huntingtons disease_Homo sapiens_hsa050160.66314208
78Glycerolipid metabolism_Homo sapiens_hsa005610.65736535
79Pentose phosphate pathway_Homo sapiens_hsa000300.62748591
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61596127
81RNA transport_Homo sapiens_hsa030130.58824423
82Nucleotide excision repair_Homo sapiens_hsa034200.56371907
83Fanconi anemia pathway_Homo sapiens_hsa034600.51322354
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50891657
85* Metabolic pathways_Homo sapiens_hsa011000.49364679
86Non-homologous end-joining_Homo sapiens_hsa034500.43958980
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43404304
88Fatty acid biosynthesis_Homo sapiens_hsa000610.41827576
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40642936
90Alzheimers disease_Homo sapiens_hsa050100.38435796
91RNA degradation_Homo sapiens_hsa030180.36763188
92Prion diseases_Homo sapiens_hsa050200.33889052
93mRNA surveillance pathway_Homo sapiens_hsa030150.33718153
94Purine metabolism_Homo sapiens_hsa002300.32796736
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32614821
96Galactose metabolism_Homo sapiens_hsa000520.29360835
97Fructose and mannose metabolism_Homo sapiens_hsa000510.28504994
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27363827
99Linoleic acid metabolism_Homo sapiens_hsa005910.21204178
100Insulin resistance_Homo sapiens_hsa049310.18376046
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17805096
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.16805785
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.12190492
104Glucagon signaling pathway_Homo sapiens_hsa049220.06157622
105Ether lipid metabolism_Homo sapiens_hsa00565-0.2566218
106Bladder cancer_Homo sapiens_hsa05219-0.2532882
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2337887
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.2263314
109Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2218164
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2198854
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2176965
112Renin-angiotensin system_Homo sapiens_hsa04614-0.1850774
113Pyrimidine metabolism_Homo sapiens_hsa00240-0.1827305
114Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1818457
115Hepatitis C_Homo sapiens_hsa05160-0.1672979
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1640074
117African trypanosomiasis_Homo sapiens_hsa05143-0.1627843
118Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1565529
119Regulation of autophagy_Homo sapiens_hsa04140-0.1460898
120Insulin signaling pathway_Homo sapiens_hsa04910-0.1390468
121Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1339031
122Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0990593
123Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0908034
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0230314
125AMPK signaling pathway_Homo sapiens_hsa04152-0.0215923
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0051764

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