QKI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.64684704
2axon ensheathment in central nervous system (GO:0032291)5.41455917
3central nervous system myelination (GO:0022010)5.41455917
4presynaptic membrane organization (GO:0097090)5.30489348
5postsynaptic membrane organization (GO:0001941)5.11496372
6neuron cell-cell adhesion (GO:0007158)4.01476259
7membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.94000044
8L-amino acid import (GO:0043092)3.91521366
9ionotropic glutamate receptor signaling pathway (GO:0035235)3.84427610
10sodium ion export (GO:0071436)3.78083081
11cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.73180168
12cerebral cortex radially oriented cell migration (GO:0021799)3.63615566
13cellular potassium ion homeostasis (GO:0030007)3.62910247
14astrocyte development (GO:0014002)3.62560670
15cell communication by electrical coupling (GO:0010644)3.60938621
16locomotory exploration behavior (GO:0035641)3.52177748
17positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.47343772
18amino acid import (GO:0043090)3.47159010
19axonal fasciculation (GO:0007413)3.46901889
20astrocyte differentiation (GO:0048708)3.45294511
21heart valve formation (GO:0003188)3.44608248
22neuron recognition (GO:0008038)3.34600875
23neuronal stem cell maintenance (GO:0097150)3.31356986
24eye photoreceptor cell differentiation (GO:0001754)3.30202329
25photoreceptor cell differentiation (GO:0046530)3.30202329
26neurotransmitter-gated ion channel clustering (GO:0072578)3.24634503
27cerebellar granule cell differentiation (GO:0021707)3.22104202
28establishment of nucleus localization (GO:0040023)3.21021154
29vocalization behavior (GO:0071625)3.20670714
30regulation of synaptic vesicle exocytosis (GO:2000300)3.19103377
31Notch signaling involved in heart development (GO:0061314)3.15675307
32regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.15328182
33membrane assembly (GO:0071709)3.15322577
34oligodendrocyte differentiation (GO:0048709)3.13838217
35neuronal action potential propagation (GO:0019227)3.11889234
36potassium ion import (GO:0010107)3.11449026
37nerve growth factor signaling pathway (GO:0038180)3.10167785
38regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.07317258
39positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.06168324
40negative regulation of neurotransmitter transport (GO:0051589)3.05727678
41pyrimidine nucleobase catabolic process (GO:0006208)3.03991526
42synaptic vesicle maturation (GO:0016188)3.01438266
43dendrite morphogenesis (GO:0048813)2.99021487
44regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.98759538
45regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.97433656
46positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.97046503
47exploration behavior (GO:0035640)2.93693240
48response to auditory stimulus (GO:0010996)2.92888550
49regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.90322349
50regulation of cardiac muscle cell contraction (GO:0086004)2.89135804
51layer formation in cerebral cortex (GO:0021819)2.87913777
52glutamate receptor signaling pathway (GO:0007215)2.86907994
53negative regulation of inclusion body assembly (GO:0090084)2.84678009
54otic vesicle formation (GO:0030916)2.84098964
55regulation of synapse structural plasticity (GO:0051823)2.83955998
56dermatan sulfate biosynthetic process (GO:0030208)2.83690651
57neurotransmitter uptake (GO:0001504)2.82722051
58central nervous system projection neuron axonogenesis (GO:0021952)2.82652476
59negative regulation of neurotransmitter secretion (GO:0046929)2.80441383
60establishment of mitochondrion localization (GO:0051654)2.79486540
61regulation of actin filament-based movement (GO:1903115)2.77840945
62auditory behavior (GO:0031223)2.77047666
63synaptic vesicle docking involved in exocytosis (GO:0016081)2.76643783
64potassium ion homeostasis (GO:0055075)2.75581298
65neuronal ion channel clustering (GO:0045161)2.74560847
66cellular sodium ion homeostasis (GO:0006883)2.73779208
67synaptic transmission, glutamatergic (GO:0035249)2.73188438
68limb bud formation (GO:0060174)2.72555487
69regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.70742830
70endocardial cushion morphogenesis (GO:0003203)2.70562681
71neuromuscular process controlling balance (GO:0050885)2.70075701
72myelination in peripheral nervous system (GO:0022011)2.69132074
73peripheral nervous system axon ensheathment (GO:0032292)2.69132074
74positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.68658478
75cellular response to cholesterol (GO:0071397)2.68139336
76cGMP-mediated signaling (GO:0019934)2.66708900
77regulation of synaptic vesicle transport (GO:1902803)2.64983230
78regulation of glutamate receptor signaling pathway (GO:1900449)2.64964120
79embryonic retina morphogenesis in camera-type eye (GO:0060059)2.64334128
80positive regulation of vascular permeability (GO:0043117)2.64148272
81startle response (GO:0001964)2.64066394
82regulation of neuronal synaptic plasticity (GO:0048168)2.62412750
83* myelination (GO:0042552)2.60190167
84protein localization to synapse (GO:0035418)2.59209096
85dendritic spine morphogenesis (GO:0060997)2.58784876
86negative regulation of oligodendrocyte differentiation (GO:0048715)2.58274543
87suckling behavior (GO:0001967)2.55508020
88cerebral cortex cell migration (GO:0021795)2.53969723
89apical protein localization (GO:0045176)2.52737661
90dermatan sulfate metabolic process (GO:0030205)2.49922305
91cell communication involved in cardiac conduction (GO:0086065)2.49623957
92* axon ensheathment (GO:0008366)2.49151777
93* ensheathment of neurons (GO:0007272)2.49151777
94mechanosensory behavior (GO:0007638)2.49007157
95regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.48710850
96glial cell differentiation (GO:0010001)2.47784817
97lateral sprouting from an epithelium (GO:0060601)2.47115327
98negative regulation of astrocyte differentiation (GO:0048712)2.46795856
99regulation of inclusion body assembly (GO:0090083)2.46394453
100positive regulation of potassium ion transport (GO:0043268)2.45746550

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.59712106
2GBX2_23144817_ChIP-Seq_PC3_Human3.23044428
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.75156304
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68219055
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.51254328
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.10144042
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.08521514
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.08151465
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.03209508
10EZH2_27304074_Chip-Seq_ESCs_Mouse1.95371004
11ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94150926
12CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94104632
13RNF2_18974828_ChIP-Seq_MESCs_Mouse1.93840227
14EZH2_18974828_ChIP-Seq_MESCs_Mouse1.93840227
15* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.93295478
16SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.91737370
17RNF2_27304074_Chip-Seq_ESCs_Mouse1.91304901
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.85676593
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81345383
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.78310525
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78206824
22OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77737844
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.77086279
24TAF15_26573619_Chip-Seq_HEK293_Human1.76491239
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73284928
26AR_21572438_ChIP-Seq_LNCaP_Human1.73017218
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.71122610
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64077134
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.62377409
30WT1_19549856_ChIP-ChIP_CCG9911_Human1.61566285
31YAP1_20516196_ChIP-Seq_MESCs_Mouse1.60205784
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59906559
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.58270088
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57910670
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57779970
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57075540
37TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55852420
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55609631
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55349930
40SMAD4_21799915_ChIP-Seq_A2780_Human1.55141647
41* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54096327
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.53856778
43P300_19829295_ChIP-Seq_ESCs_Human1.49679888
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.49436347
45DROSHA_22980978_ChIP-Seq_HELA_Human1.45065844
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.44842734
47REST_21632747_ChIP-Seq_MESCs_Mouse1.44198140
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.44098476
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43543974
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39676549
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39516054
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38604374
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38206488
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.37284933
55TP53_16413492_ChIP-PET_HCT116_Human1.36511806
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35066664
57STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.34370879
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33595172
59* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33476536
60LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33390470
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.31570466
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.31516369
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.31431293
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.31431293
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30638876
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30638876
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30265438
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29912753
69TRIM28_21343339_ChIP-Seq_HEK293_Human1.29149879
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28114695
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28044108
72CTNNB1_20460455_ChIP-Seq_HCT116_Human1.28023522
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.26069657
74RARB_27405468_Chip-Seq_BRAIN_Mouse1.25820429
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25497843
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.24403417
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24365552
78RNF2_27304074_Chip-Seq_NSC_Mouse1.23472304
79SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21327415
80ISL1_27105846_Chip-Seq_CPCs_Mouse1.21038844
81TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.21026974
82SOX9_26525672_Chip-Seq_HEART_Mouse1.19989619
83CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19140810
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18984654
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17585490
86* STAT3_23295773_ChIP-Seq_U87_Human1.17365360
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17305863
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.17054177
89RING1B_27294783_Chip-Seq_NPCs_Mouse1.14626885
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12660582
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12412114
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11688490
93CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11404033
94SMAD3_21741376_ChIP-Seq_HESCs_Human1.11205598
95FUS_26573619_Chip-Seq_HEK293_Human1.11153323
96IGF1R_20145208_ChIP-Seq_DFB_Human1.09737393
97TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08929344
98KDM2B_26808549_Chip-Seq_REH_Human1.06462331
99TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06180077
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05923502

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.31010113
2MP0004270_analgesia3.52034900
3MP0003136_yellow_coat_color3.49577112
4MP0000778_abnormal_nervous_system3.07233760
5MP0003690_abnormal_glial_cell2.65121950
6MP0003880_abnormal_central_pattern2.63841083
7MP0003635_abnormal_synaptic_transmissio2.52541525
8MP0004885_abnormal_endolymph2.52301795
9MP0005423_abnormal_somatic_nervous2.50470118
10MP0001486_abnormal_startle_reflex2.49416577
11MP0005171_absent_coat_pigmentation2.28611488
12MP0002063_abnormal_learning/memory/cond2.12284624
13MP0002064_seizures2.08208112
14MP0000569_abnormal_digit_pigmentation2.03998880
15MP0000920_abnormal_myelination1.94929997
16MP0002734_abnormal_mechanical_nocicepti1.89472671
17MP0003634_abnormal_glial_cell1.87478953
18MP0001984_abnormal_olfaction1.77327099
19MP0000955_abnormal_spinal_cord1.71952940
20MP0009745_abnormal_behavioral_response1.71160820
21MP0002272_abnormal_nervous_system1.69036356
22MP0002735_abnormal_chemical_nociception1.68677003
23MP0008569_lethality_at_weaning1.66333980
24MP0003329_amyloid_beta_deposits1.66294728
25MP0001177_atelectasis1.66068983
26MP0001299_abnormal_eye_distance/1.65527790
27MP0002572_abnormal_emotion/affect_behav1.65136988
28MP0005248_abnormal_Harderian_gland1.63338575
29MP0004084_abnormal_cardiac_muscle1.55423374
30MP0002638_abnormal_pupillary_reflex1.55340381
31MP0003632_abnormal_nervous_system1.52255340
32MP0002736_abnormal_nociception_after1.46957638
33MP0001958_emphysema1.42521214
34MP0002067_abnormal_sensory_capabilities1.40115931
35MP0004811_abnormal_neuron_physiology1.34953208
36MP0002882_abnormal_neuron_morphology1.32333631
37MP0002152_abnormal_brain_morphology1.32249030
38MP0003122_maternal_imprinting1.31801063
39MP0001968_abnormal_touch/_nociception1.30418432
40MP0004215_abnormal_myocardial_fiber1.29861445
41MP0000749_muscle_degeneration1.29008347
42MP0003633_abnormal_nervous_system1.27424917
43MP0000566_synostosis1.26749636
44MP0005187_abnormal_penis_morphology1.26544401
45MP0000751_myopathy1.22001595
46MP0001502_abnormal_circadian_rhythm1.21629385
47MP0000747_muscle_weakness1.19316264
48MP0000428_abnormal_craniofacial_morphol1.17592985
49MP0003631_nervous_system_phenotype1.17026323
50MP0009046_muscle_twitch1.14942123
51MP0002557_abnormal_social/conspecific_i1.11046984
52MP0001970_abnormal_pain_threshold1.09323370
53MP0002653_abnormal_ependyma_morphology1.09003325
54MP0001485_abnormal_pinna_reflex1.08828323
55MP0004036_abnormal_muscle_relaxation1.08787634
56MP0005167_abnormal_blood-brain_barrier1.06260683
57MP0000537_abnormal_urethra_morphology1.06195768
58MP0004130_abnormal_muscle_cell1.05907963
59MP0002066_abnormal_motor_capabilities/c1.05698918
60MP0004145_abnormal_muscle_electrophysio1.04785830
61MP0004924_abnormal_behavior1.03098266
62MP0005386_behavior/neurological_phenoty1.03098266
63MP0003861_abnormal_nervous_system1.00885704
64MP0002184_abnormal_innervation0.99947476
65MP0005620_abnormal_muscle_contractility0.99855877
66MP0001963_abnormal_hearing_physiology0.99830989
67MP0000026_abnormal_inner_ear0.99597399
68MP0001529_abnormal_vocalization0.99541663
69MP0000534_abnormal_ureter_morphology0.96013867
70MP0002249_abnormal_larynx_morphology0.95806836
71MP0001440_abnormal_grooming_behavior0.95515175
72MP0006138_congestive_heart_failure0.94472818
73MP0005409_darkened_coat_color0.93034696
74MP0003137_abnormal_impulse_conducting0.92767910
75MP0004087_abnormal_muscle_fiber0.92000097
76MP0002133_abnormal_respiratory_system0.89517447
77MP0005388_respiratory_system_phenotype0.89517447
78MP0002733_abnormal_thermal_nociception0.87535797
79MP0003705_abnormal_hypodermis_morpholog0.87111318
80MP0004142_abnormal_muscle_tone0.86594018
81MP0000579_abnormal_nail_morphology0.83844246
82MP0002972_abnormal_cardiac_muscle0.83182087
83MP0002752_abnormal_somatic_nervous0.82566982
84MP0004858_abnormal_nervous_system0.80709380
85MP0002233_abnormal_nose_morphology0.80703455
86MP0003935_abnormal_craniofacial_develop0.80511210
87MP0005623_abnormal_meninges_morphology0.80060214
88MP0005646_abnormal_pituitary_gland0.79479770
89MP0003938_abnormal_ear_development0.79418460
90MP0000631_abnormal_neuroendocrine_gland0.78716671
91MP0003755_abnormal_palate_morphology0.77464140
92MP0003091_abnormal_cell_migration0.77437157
93MP0005595_abnormal_vascular_smooth0.77315375
94MP0003937_abnormal_limbs/digits/tail_de0.76198395
95MP0003385_abnormal_body_wall0.75566856
96MP0000762_abnormal_tongue_morphology0.75532351
97MP0009780_abnormal_chondrocyte_physiolo0.75183103
98MP0001879_abnormal_lymphatic_vessel0.74671698
99MP0000049_abnormal_middle_ear0.74456826
100MP0010630_abnormal_cardiac_muscle0.74227891

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.15900273
2Action tremor (HP:0002345)3.43657600
3Megalencephaly (HP:0001355)3.38259594
4Neurofibrillary tangles (HP:0002185)3.26356169
5Neonatal short-limb short stature (HP:0008921)3.22363260
6Abnormality of the ischium (HP:0003174)3.17341654
7Hemiplegia (HP:0002301)3.10646979
8Split foot (HP:0001839)2.91597840
9Focal seizures (HP:0007359)2.84718475
10Difficulty running (HP:0009046)2.84313609
11Scanning speech (HP:0002168)2.79670966
12Aplasia involving bones of the upper limbs (HP:0009823)2.78677687
13Aplasia of the phalanges of the hand (HP:0009802)2.78677687
14Aplasia involving bones of the extremities (HP:0009825)2.78677687
15Febrile seizures (HP:0002373)2.74115002
16Atonic seizures (HP:0010819)2.68548439
17Hemiparesis (HP:0001269)2.59600990
18Subaortic stenosis (HP:0001682)2.56553913
19Abnormality of the left ventricular outflow tract (HP:0011103)2.56553913
20Pheochromocytoma (HP:0002666)2.55742442
21Vertebral arch anomaly (HP:0008438)2.54946957
22Abnormality of the corticospinal tract (HP:0002492)2.52352558
23Degeneration of the lateral corticospinal tracts (HP:0002314)2.43986173
24Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.43986173
25Arterial tortuosity (HP:0005116)2.42151515
26Turricephaly (HP:0000262)2.37331450
27Short 4th metacarpal (HP:0010044)2.36665281
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.36665281
29Cerebral inclusion bodies (HP:0100314)2.35189539
30Vascular tortuosity (HP:0004948)2.31933014
31Hyporeflexia of lower limbs (HP:0002600)2.31881960
32Papillary thyroid carcinoma (HP:0002895)2.31880669
33Thickened helices (HP:0000391)2.25011804
34Abnormality of the 4th metacarpal (HP:0010012)2.24912435
35Bronchomalacia (HP:0002780)2.24874094
36Abnormality of the diencephalon (HP:0010662)2.22732219
37Drooling (HP:0002307)2.20769347
38Vitreoretinal degeneration (HP:0000655)2.20641045
39Exercise-induced muscle cramps (HP:0003710)2.20499807
40Coronal craniosynostosis (HP:0004440)2.19230683
41Wide anterior fontanel (HP:0000260)2.17597003
42Bundle branch block (HP:0011710)2.17502606
43Septo-optic dysplasia (HP:0100842)2.16322775
44Cutaneous finger syndactyly (HP:0010554)2.14257987
45Alacrima (HP:0000522)2.12098915
46Myokymia (HP:0002411)2.11092964
47Generalized tonic-clonic seizures (HP:0002069)2.10894986
48Hammertoe (HP:0001765)2.07562736
49Excessive salivation (HP:0003781)2.01846725
50Ankle clonus (HP:0011448)2.01244708
51Thin ribs (HP:0000883)1.99223783
52Mild short stature (HP:0003502)1.98324618
53Spastic gait (HP:0002064)1.96778675
54Hypoplastic ischia (HP:0003175)1.95635675
55Cutaneous syndactyly (HP:0012725)1.93716131
56Lower limb muscle weakness (HP:0007340)1.93636499
57Cortical dysplasia (HP:0002539)1.92103745
58Shallow orbits (HP:0000586)1.90671139
59Aplasia/Hypoplasia of the sternum (HP:0006714)1.88956934
60Neuroendocrine neoplasm (HP:0100634)1.88805907
61Abnormality of the lower motor neuron (HP:0002366)1.87977569
62Obstructive sleep apnea (HP:0002870)1.87614874
63Hypoplasia of the iris (HP:0007676)1.87022842
64Aqueductal stenosis (HP:0002410)1.86853896
65Steppage gait (HP:0003376)1.86652594
66Abnormality of the foot musculature (HP:0001436)1.84244331
67Truncal ataxia (HP:0002078)1.83880169
68Urinary bladder sphincter dysfunction (HP:0002839)1.83755907
69Neoplasm of the heart (HP:0100544)1.83093454
70Abnormal eating behavior (HP:0100738)1.82639491
71Tracheomalacia (HP:0002779)1.81134502
72Trigonocephaly (HP:0000243)1.80079139
73Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.79133445
74Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.78793873
75Large earlobe (HP:0009748)1.78694862
76Sudden death (HP:0001699)1.78002496
77Peripheral hypomyelination (HP:0007182)1.77172093
78Abnormality of binocular vision (HP:0011514)1.75576915
79Diplopia (HP:0000651)1.75576915
80Decreased lacrimation (HP:0000633)1.75121368
81Epileptic encephalopathy (HP:0200134)1.73575379
82Foot dorsiflexor weakness (HP:0009027)1.72044375
83Missing ribs (HP:0000921)1.71948646
84Partial duplication of thumb phalanx (HP:0009944)1.70826459
85Muscle fiber splitting (HP:0003555)1.70771669
86Supernumerary ribs (HP:0005815)1.70577832
87Limited hip movement (HP:0008800)1.70265478
88Blue irides (HP:0000635)1.70026874
89Hepatoblastoma (HP:0002884)1.69011695
90Inappropriate behavior (HP:0000719)1.67090250
91Termporal pattern (HP:0011008)1.66996517
92Insidious onset (HP:0003587)1.66996517
93Postural instability (HP:0002172)1.66181708
94Urinary urgency (HP:0000012)1.64687660
95Hyperventilation (HP:0002883)1.64243664
96Morphological abnormality of the middle ear (HP:0008609)1.63846848
97Dysdiadochokinesis (HP:0002075)1.60392676
98Decreased motor nerve conduction velocity (HP:0003431)1.60163352
99Hamartoma (HP:0010566)1.60042572
100Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.58513232

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.14869403
2CASK3.90284253
3TNIK3.52588971
4NTRK23.47447129
5PNCK3.24713699
6NTRK32.79226094
7NTRK12.65676826
8EPHA42.35328136
9PAK62.08455610
10UHMK11.99238770
11OBSCN1.94446702
12TYRO31.90886545
13LATS21.74144677
14FGFR21.68858648
15EPHB21.64556318
16MOS1.61994357
17KSR11.60889734
18SGK21.48141888
19PLK21.43762684
20ROCK21.41549888
21MAPK151.41450515
22PRKD31.37203156
23SGK2231.26968737
24SGK4941.26968737
25PDGFRA1.26244657
26KSR21.22834349
27CAMK1G1.21537569
28PKN11.21256603
29DMPK1.16783572
30EPHA31.15615980
31MKNK21.13716291
32YES11.10105638
33RIPK11.09209255
34MAPK131.08178461
35NEK91.06489003
36CDK51.04141022
37SGK31.04051931
38PHKG21.01825985
39PHKG11.01825985
40ROCK11.00170851
41CAMK2B0.99767390
42MAP3K40.97623460
43BRD40.92450445
44MINK10.92440796
45WNK10.89926004
46MAPK100.88329847
47MAP3K90.86752229
48PINK10.86472710
49PDGFRB0.86004776
50BCR0.85726930
51LATS10.85573132
52CSNK1G20.84668020
53WEE10.79061399
54CAMK2D0.78666728
55ERBB30.78444901
56FGFR10.73061008
57PKN20.72972725
58DYRK1A0.72724498
59CAMK2A0.72508085
60SIK20.72125789
61STK390.70350041
62ERBB20.69959569
63RET0.68396233
64CAMKK10.68166828
65PRKCG0.67644772
66MKNK10.66999757
67SGK10.66417679
68CAMK2G0.66407394
69RAF10.64005195
70CDK180.59003471
71CDK150.58909390
72DDR20.58371075
73TSSK60.57699039
74FGFR30.57029203
75CDK30.56784348
76CAMK1D0.54818229
77STK38L0.54427903
78NEK60.53659048
79PRKCH0.52689476
80MAP3K100.51531388
81CAMK10.49749451
82PAK20.49644978
83PRKG10.49548117
84CDK11A0.48827889
85STK110.47431706
86FES0.46856988
87CDK140.45251467
88MAP2K40.44058340
89RPS6KA30.43829161
90DYRK20.40128386
91TTN0.39026605
92CAMK40.38680058
93PRKD10.38538300
94MARK20.38515140
95MAPK120.37500653
96PAK30.37148989
97CCNB10.36956991
98FGR0.36632856
99WNK30.36599431
100MAPK70.34942266

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.59361394
2Circadian entrainment_Homo sapiens_hsa047132.16098027
3Long-term potentiation_Homo sapiens_hsa047202.15076671
4Glutamatergic synapse_Homo sapiens_hsa047242.04889755
5GABAergic synapse_Homo sapiens_hsa047271.87180623
6Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.79959983
7Amphetamine addiction_Homo sapiens_hsa050311.77566749
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.77072815
9Dilated cardiomyopathy_Homo sapiens_hsa054141.68957063
10Dorso-ventral axis formation_Homo sapiens_hsa043201.68407024
11Morphine addiction_Homo sapiens_hsa050321.66302778
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58893246
13Dopaminergic synapse_Homo sapiens_hsa047281.55326390
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.54070554
15Cocaine addiction_Homo sapiens_hsa050301.51409923
16cAMP signaling pathway_Homo sapiens_hsa040241.50878845
17Gastric acid secretion_Homo sapiens_hsa049711.50295044
18Axon guidance_Homo sapiens_hsa043601.50135031
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.47633403
20Estrogen signaling pathway_Homo sapiens_hsa049151.45731580
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43837337
22Cholinergic synapse_Homo sapiens_hsa047251.42275564
23Gap junction_Homo sapiens_hsa045401.40143668
24Adherens junction_Homo sapiens_hsa045201.37200272
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.36014667
26Oxytocin signaling pathway_Homo sapiens_hsa049211.35060249
27Prion diseases_Homo sapiens_hsa050201.34904156
28Insulin secretion_Homo sapiens_hsa049111.33724326
29Renin secretion_Homo sapiens_hsa049241.29664983
30Melanogenesis_Homo sapiens_hsa049161.27794817
31Phospholipase D signaling pathway_Homo sapiens_hsa040721.24473237
32Long-term depression_Homo sapiens_hsa047301.22845173
33ErbB signaling pathway_Homo sapiens_hsa040121.21348593
34Endometrial cancer_Homo sapiens_hsa052131.21210716
35Glioma_Homo sapiens_hsa052141.20643788
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18665174
37Renal cell carcinoma_Homo sapiens_hsa052111.17313426
38Hippo signaling pathway_Homo sapiens_hsa043901.16622116
39Hedgehog signaling pathway_Homo sapiens_hsa043401.15843926
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15749157
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.13855728
42Basal cell carcinoma_Homo sapiens_hsa052171.11071289
43Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10748025
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09951218
45Rap1 signaling pathway_Homo sapiens_hsa040151.09949556
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07332176
47Salivary secretion_Homo sapiens_hsa049701.06860698
48Colorectal cancer_Homo sapiens_hsa052101.05702526
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.05699703
50Circadian rhythm_Homo sapiens_hsa047101.03189310
51Calcium signaling pathway_Homo sapiens_hsa040201.02284664
52GnRH signaling pathway_Homo sapiens_hsa049121.01315091
53Tight junction_Homo sapiens_hsa045301.00434540
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98483089
55Notch signaling pathway_Homo sapiens_hsa043300.98454294
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98410350
57Wnt signaling pathway_Homo sapiens_hsa043100.98131046
58Focal adhesion_Homo sapiens_hsa045100.95534690
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93449109
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90428221
61MicroRNAs in cancer_Homo sapiens_hsa052060.89132701
62Thyroid hormone synthesis_Homo sapiens_hsa049180.89004666
63Synaptic vesicle cycle_Homo sapiens_hsa047210.87241900
64Ras signaling pathway_Homo sapiens_hsa040140.86991684
65Choline metabolism in cancer_Homo sapiens_hsa052310.86408665
66ECM-receptor interaction_Homo sapiens_hsa045120.84072249
67Taste transduction_Homo sapiens_hsa047420.81404065
68MAPK signaling pathway_Homo sapiens_hsa040100.79355481
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76881590
70Bile secretion_Homo sapiens_hsa049760.74480320
71Chronic myeloid leukemia_Homo sapiens_hsa052200.72144686
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70958077
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70736554
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.70346875
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69289005
76Serotonergic synapse_Homo sapiens_hsa047260.67153214
77Pancreatic secretion_Homo sapiens_hsa049720.65061990
78Type II diabetes mellitus_Homo sapiens_hsa049300.65030190
79Insulin signaling pathway_Homo sapiens_hsa049100.64374590
80Oocyte meiosis_Homo sapiens_hsa041140.64215733
81Proteoglycans in cancer_Homo sapiens_hsa052050.64103534
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63462418
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63298257
84Amoebiasis_Homo sapiens_hsa051460.61471164
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61412078
86Inositol phosphate metabolism_Homo sapiens_hsa005620.61403540
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61361201
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61250558
89VEGF signaling pathway_Homo sapiens_hsa043700.61041861
90Melanoma_Homo sapiens_hsa052180.59296606
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58902019
92TGF-beta signaling pathway_Homo sapiens_hsa043500.58572494
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.58140774
94AMPK signaling pathway_Homo sapiens_hsa041520.57569292
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57564018
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.57487790
97Cardiac muscle contraction_Homo sapiens_hsa042600.56791484
98PPAR signaling pathway_Homo sapiens_hsa033200.56495415
99mTOR signaling pathway_Homo sapiens_hsa041500.56013557
100FoxO signaling pathway_Homo sapiens_hsa040680.54816835

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