QDPR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.51381862
2central nervous system myelination (GO:0022010)9.51381862
3synaptic vesicle maturation (GO:0016188)7.37678771
4synaptic vesicle docking involved in exocytosis (GO:0016081)7.10414453
5glutamate secretion (GO:0014047)7.03735269
6fatty acid elongation (GO:0030497)6.63401350
7synaptic vesicle exocytosis (GO:0016079)6.24221612
8regulation of synaptic vesicle exocytosis (GO:2000300)5.84083476
9* L-phenylalanine catabolic process (GO:0006559)5.76122597
10* erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.76122597
11cellular potassium ion homeostasis (GO:0030007)5.73910544
12regulation of short-term neuronal synaptic plasticity (GO:0048172)5.53715421
13neurotransmitter secretion (GO:0007269)5.39557946
14* L-phenylalanine metabolic process (GO:0006558)5.28444298
15* erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.28444298
16membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.28322030
17regulation of synaptic vesicle transport (GO:1902803)5.17023985
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.06859686
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.04463321
20sodium ion export (GO:0071436)5.01165188
21axon ensheathment (GO:0008366)4.85638740
22ensheathment of neurons (GO:0007272)4.85638740
23myelination (GO:0042552)4.84572866
24neuronal action potential propagation (GO:0019227)4.73191988
25regulation of neuronal synaptic plasticity (GO:0048168)4.54388098
26neurotransmitter transport (GO:0006836)4.49684714
27potassium ion homeostasis (GO:0055075)4.41333274
28* aromatic amino acid family catabolic process (GO:0009074)4.38833273
29locomotory exploration behavior (GO:0035641)4.30120617
30very long-chain fatty acid metabolic process (GO:0000038)4.28218835
31positive regulation of synapse maturation (GO:0090129)4.27904863
32myelin maintenance (GO:0043217)4.19810015
33potassium ion import (GO:0010107)4.19035496
34regulation of neurotransmitter levels (GO:0001505)4.16794816
35regulation of long-term neuronal synaptic plasticity (GO:0048169)4.14306561
36negative regulation of synaptic transmission, GABAergic (GO:0032229)4.14231550
37amino acid import (GO:0043090)4.09539071
38cholesterol biosynthetic process (GO:0006695)4.09371397
39neuronal ion channel clustering (GO:0045161)4.08515055
40glyoxylate metabolic process (GO:0046487)4.03596276
41bile acid biosynthetic process (GO:0006699)4.01532322
42heme transport (GO:0015886)4.01153006
43long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.99361898
44creatine metabolic process (GO:0006600)3.98532024
45ionotropic glutamate receptor signaling pathway (GO:0035235)3.94738011
46neurotransmitter uptake (GO:0001504)3.94672113
47response to methylmercury (GO:0051597)3.93139550
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.91804387
49fatty-acyl-CoA biosynthetic process (GO:0046949)3.88039255
50regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.82989634
51exploration behavior (GO:0035640)3.81183708
52cerebellar granule cell differentiation (GO:0021707)3.80191238
53long-chain fatty acid biosynthetic process (GO:0042759)3.76450374
54synaptic transmission, glutamatergic (GO:0035249)3.75051535
55alpha-linolenic acid metabolic process (GO:0036109)3.73336091
56regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.65164037
57positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.64104298
58neurotransmitter-gated ion channel clustering (GO:0072578)3.63517488
59sterol biosynthetic process (GO:0016126)3.63497340
60gamma-aminobutyric acid transport (GO:0015812)3.63222360
61regulation of neurotransmitter secretion (GO:0046928)3.62235346
62coenzyme catabolic process (GO:0009109)3.62145044
63fatty-acyl-CoA metabolic process (GO:0035337)3.61497494
64vocalization behavior (GO:0071625)3.61154000
65postsynaptic membrane organization (GO:0001941)3.60545021
66positive regulation of dendritic spine development (GO:0060999)3.60385921
67neuron-neuron synaptic transmission (GO:0007270)3.59213238
68L-serine metabolic process (GO:0006563)3.59021145
69positive regulation of membrane potential (GO:0045838)3.58353381
70tyrosine metabolic process (GO:0006570)3.57893541
71detection of calcium ion (GO:0005513)3.57333548
72cysteine metabolic process (GO:0006534)3.56783481
73regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.55602880
74regulation of voltage-gated calcium channel activity (GO:1901385)3.53956445
75synaptic vesicle endocytosis (GO:0048488)3.51800118
76regulation of neurotransmitter transport (GO:0051588)3.51188073
77positive regulation of neurotransmitter transport (GO:0051590)3.50557956
78regulation of synaptic plasticity (GO:0048167)3.49832941
79cellular sodium ion homeostasis (GO:0006883)3.48326471
80regulation of synapse structural plasticity (GO:0051823)3.46420350
81regulation of glutamate receptor signaling pathway (GO:1900449)3.45837233
82establishment of mitochondrion localization (GO:0051654)3.45605232
83bile acid metabolic process (GO:0008206)3.44185954
84long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.42994498
85aspartate family amino acid catabolic process (GO:0009068)3.42641409
86regulation of vesicle fusion (GO:0031338)3.42502698
87protein localization to synapse (GO:0035418)3.41861259
88glycerophospholipid catabolic process (GO:0046475)3.40024982
89thioester biosynthetic process (GO:0035384)3.39179609
90acyl-CoA biosynthetic process (GO:0071616)3.39179609
91iron coordination entity transport (GO:1901678)3.38948835
92dicarboxylic acid catabolic process (GO:0043649)3.38777796
93cofactor catabolic process (GO:0051187)3.36644547
94regulation of excitatory postsynaptic membrane potential (GO:0060079)3.35594545
95acidic amino acid transport (GO:0015800)3.34517698
96positive regulation of cellular amine metabolic process (GO:0033240)3.34367341
97triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.33262826
98neuromuscular process controlling posture (GO:0050884)3.32667055
99oligodendrocyte differentiation (GO:0048709)3.31197106
100neuron cell-cell adhesion (GO:0007158)3.30620841
101indole-containing compound catabolic process (GO:0042436)3.30217682
102indolalkylamine catabolic process (GO:0046218)3.30217682
103tryptophan catabolic process (GO:0006569)3.30217682
104amyloid precursor protein metabolic process (GO:0042982)3.29892843
105serine family amino acid biosynthetic process (GO:0009070)3.29282483
106cell communication by electrical coupling (GO:0010644)3.28982945
107regulation of synapse maturation (GO:0090128)3.28855446
108short-chain fatty acid metabolic process (GO:0046459)3.27863902
109positive regulation of neurotransmitter secretion (GO:0001956)3.27284924
110glutamate metabolic process (GO:0006536)3.27262913
111cellular ketone body metabolic process (GO:0046950)3.25625461
112regulation of catecholamine metabolic process (GO:0042069)3.23154079
113regulation of dopamine metabolic process (GO:0042053)3.23154079
114glutamate receptor signaling pathway (GO:0007215)3.22246582
115dendritic spine morphogenesis (GO:0060997)3.21785208
116aldehyde catabolic process (GO:0046185)3.18667835
117neuromuscular process controlling balance (GO:0050885)3.18214724
118auditory behavior (GO:0031223)3.16117940
119negative regulation of dendrite morphogenesis (GO:0050774)3.15455705
120long-term synaptic potentiation (GO:0060291)3.14917689
121acyl-CoA metabolic process (GO:0006637)3.14791141
122thioester metabolic process (GO:0035383)3.14791141
123response to mercury ion (GO:0046689)3.13804214
124tryptophan metabolic process (GO:0006568)3.12928382
125kynurenine metabolic process (GO:0070189)3.12153250
126regulation of lipoprotein metabolic process (GO:0050746)3.10897837
127* aromatic amino acid family metabolic process (GO:0009072)3.08675912
128regulation of postsynaptic membrane potential (GO:0060078)3.08398196
129positive regulation of oligodendrocyte differentiation (GO:0048714)3.08126905
130negative regulation of neurotransmitter secretion (GO:0046929)3.07926885
131regulation of collateral sprouting (GO:0048670)3.06038042
132negative regulation of neurotransmitter transport (GO:0051589)3.05821137
133regulation of dendritic spine morphogenesis (GO:0061001)3.05490107
134gamma-aminobutyric acid signaling pathway (GO:0007214)3.05105089
135establishment of synaptic vesicle localization (GO:0097480)3.04729206
136synaptic vesicle transport (GO:0048489)3.04729206
137regulation of dendritic spine development (GO:0060998)3.04330996
138positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.03511812
139sulfur amino acid catabolic process (GO:0000098)3.02865371
140* alpha-amino acid catabolic process (GO:1901606)3.02298930
141membrane depolarization during action potential (GO:0086010)3.00485819
142acetyl-CoA metabolic process (GO:0006084)3.00121004
143presynaptic membrane organization (GO:0097090)2.98662173
144amyloid precursor protein catabolic process (GO:0042987)2.98373296
145proline transport (GO:0015824)2.98353252
146cerebellar Purkinje cell layer development (GO:0021680)2.97775970
147L-glutamate transport (GO:0015813)2.96830939
148ethanol oxidation (GO:0006069)2.96787436
149regulation of ARF protein signal transduction (GO:0032012)2.94807098
150high-density lipoprotein particle remodeling (GO:0034375)2.94674365
151glutathione biosynthetic process (GO:0006750)2.93082645
152regulation of synaptic transmission (GO:0050804)2.92424245
153regulation of cholesterol esterification (GO:0010872)2.91411854
154synaptic transmission (GO:0007268)2.91138235
155* cellular amino acid catabolic process (GO:0009063)2.90877163
156transmission of nerve impulse (GO:0019226)2.90845455
157vesicle docking involved in exocytosis (GO:0006904)2.89472091
158substantia nigra development (GO:0021762)2.89196155
159membrane depolarization (GO:0051899)2.87544007
160regulation of fibrinolysis (GO:0051917)2.87300400
161dicarboxylic acid transport (GO:0006835)2.86301613
162regulation of cell communication by electrical coupling (GO:0010649)2.85782065
163ketone body metabolic process (GO:1902224)2.84032149
164regulation of cholesterol biosynthetic process (GO:0045540)2.83906263
165regulation of cholesterol metabolic process (GO:0090181)2.83751954
166signal release (GO:0023061)2.83492330
167plasma lipoprotein particle clearance (GO:0034381)2.83290637
168long-term memory (GO:0007616)2.83262363
169negative regulation of fibrinolysis (GO:0051918)2.83110045
170serine family amino acid metabolic process (GO:0009069)2.83051145
171isoprenoid biosynthetic process (GO:0008299)2.82964918
172cholesterol metabolic process (GO:0008203)2.82648890
173fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.82525479
174regulation of triglyceride catabolic process (GO:0010896)2.78601662
175response to auditory stimulus (GO:0010996)2.77528096
176glutathione derivative metabolic process (GO:1901685)2.76533640
177glutathione derivative biosynthetic process (GO:1901687)2.76533640
178protein carboxylation (GO:0018214)2.75361263
179peptidyl-glutamic acid carboxylation (GO:0017187)2.75361263
180regulation of exocytosis (GO:0017157)2.75357099
181nonribosomal peptide biosynthetic process (GO:0019184)2.75344778
182import into cell (GO:0098657)2.74170862
183membrane hyperpolarization (GO:0060081)2.72653183
184vesicle docking (GO:0048278)2.71949959
185L-amino acid import (GO:0043092)2.70441708
186negative regulation of protein localization to cell surface (GO:2000009)2.69773721
187opsonization (GO:0008228)2.68690028
188steroid biosynthetic process (GO:0006694)2.67515744
189membrane tubulation (GO:0097320)2.67092835
190drug transmembrane transport (GO:0006855)2.66093155
191sterol metabolic process (GO:0016125)2.65188818
192protein import into peroxisome matrix (GO:0016558)2.64502176
193cholesterol efflux (GO:0033344)2.63022740
194positive regulation of lipoprotein lipase activity (GO:0051006)2.63014939
195positive regulation of triglyceride lipase activity (GO:0061365)2.63014939

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.19387123
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.34457217
3EGR1_23403033_ChIP-Seq_LIVER_Mouse3.57370962
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.49081117
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.36510176
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.06645521
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.66612917
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.60964460
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.41243360
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19234945
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14661048
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.14373756
13SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.10438146
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09623438
15TAF15_26573619_Chip-Seq_HEK293_Human2.04996096
16* CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.04386856
17GBX2_23144817_ChIP-Seq_PC3_Human2.03291475
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94678097
19RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.93473916
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.93128169
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.91375619
22RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.90427675
23HTT_18923047_ChIP-ChIP_STHdh_Human1.75942156
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61350646
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58308014
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.55214308
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53762919
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53076526
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.52766821
30NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45217306
31SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41151532
32TET1_21490601_ChIP-Seq_MESCs_Mouse1.38770247
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37763735
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36580242
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32713452
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.31699108
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.29784883
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.29214530
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.26765486
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.26765486
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24075745
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21319052
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21023301
44* FOXA2_19822575_ChIP-Seq_HepG2_Human1.20777203
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.19742558
46EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18972765
47VDR_22108803_ChIP-Seq_LS180_Human1.18252641
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17246261
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17246261
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.17159128
51SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16342029
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15700635
53PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15545077
54OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.15141726
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13787475
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13648498
57EZH2_27304074_Chip-Seq_ESCs_Mouse1.13635516
58EED_16625203_ChIP-ChIP_MESCs_Mouse1.12760420
59JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12587868
60AR_21572438_ChIP-Seq_LNCaP_Human1.12425634
61* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12239601
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11957902
63EZH2_22144423_ChIP-Seq_EOC_Human1.11485887
64EOMES_21245162_ChIP-Seq_HESCs_Human1.11090326
65ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08914979
66SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08685790
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08278693
68KDM2B_26808549_Chip-Seq_K562_Human1.08102562
69RARB_27405468_Chip-Seq_BRAIN_Mouse1.07715301
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07107920
71ER_23166858_ChIP-Seq_MCF-7_Human1.06116362
72REST_18959480_ChIP-ChIP_MESCs_Mouse1.04268869
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03984947
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.03819408
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03201337
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02680542
77RNF2_27304074_Chip-Seq_NSC_Mouse1.02126214
78SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00745109
79DROSHA_22980978_ChIP-Seq_HELA_Human1.00711912
80* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98806430
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98122137
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98072740
83REST_21632747_ChIP-Seq_MESCs_Mouse0.96563886
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96413406
85SOX2_21211035_ChIP-Seq_LN229_Gbm0.95622972
86SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95041042
87* AR_19668381_ChIP-Seq_PC3_Human0.94517066
88OCT4_20526341_ChIP-Seq_ESCs_Human0.94309080
89CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93998331
90SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93869942
91OCT4_19829295_ChIP-Seq_ESCs_Human0.92556740
92SMAD4_21799915_ChIP-Seq_A2780_Human0.92476485
93DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92437168
94FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91230235
95SOX2_19829295_ChIP-Seq_ESCs_Human0.91045585
96NANOG_19829295_ChIP-Seq_ESCs_Human0.91045585
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90972262
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90590052
99NCOR_22424771_ChIP-Seq_293T_Human0.89832471
100SMAD3_21741376_ChIP-Seq_EPCs_Human0.89637369
101FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89595258
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88059850
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87612128
104DPY_21335234_ChIP-Seq_ESCs_Mouse0.87345224
105CBP_21632823_ChIP-Seq_H3396_Human0.86996475
106CTCF_20526341_ChIP-Seq_ESCs_Human0.86844104
107TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.84589331
108SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83748464
109ESR2_21235772_ChIP-Seq_MCF-7_Human0.81441973
110* TAL1_26923725_Chip-Seq_HPCs_Mouse0.81418693
111ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80800959
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80257470
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80243079
114LXR_22292898_ChIP-Seq_THP-1_Human0.80152812
115LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79983908
116RNF2_27304074_Chip-Seq_ESCs_Mouse0.79848419
117RING1B_27294783_Chip-Seq_NPCs_Mouse0.78408805
118IRF1_19129219_ChIP-ChIP_H3396_Human0.78351682
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78282549
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.77863044
121CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.77104381
122WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.76990296
123SMC4_20622854_ChIP-Seq_HELA_Human0.76053738
124PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.75930345
125PIAS1_25552417_ChIP-Seq_VCAP_Human0.75926587
126AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75819308
127P300_19829295_ChIP-Seq_ESCs_Human0.75473440
128FOXA1_25552417_ChIP-Seq_VCAP_Human0.75116534
129CTCF_27219007_Chip-Seq_Bcells_Human0.74583685
130SMAD4_21741376_ChIP-Seq_ESCs_Human0.73292129
131NANOG_20526341_ChIP-Seq_ESCs_Human0.73160223
132NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.73094314
133ZFP281_27345836_Chip-Seq_ESCs_Mouse0.73021220
134TCF4_23295773_ChIP-Seq_U87_Human0.72996744
135GATA1_26923725_Chip-Seq_HPCs_Mouse0.72608648
136SMAD3_21741376_ChIP-Seq_ESCs_Human0.72328274
137CBX2_27304074_Chip-Seq_ESCs_Mouse0.71964348
138SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.71853704
139SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.71576816
140SMAD4_21741376_ChIP-Seq_EPCs_Human0.71407733
141P53_22127205_ChIP-Seq_FIBROBLAST_Human0.71272902
142KLF4_19829295_ChIP-Seq_ESCs_Human0.71002411
143CDX2_19796622_ChIP-Seq_MESCs_Mouse0.70995148
144MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.70272159
145RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70243983
146SMAD4_21741376_ChIP-Seq_HESCs_Human0.70024093
147RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.69799123
148EGR1_19032775_ChIP-ChIP_M12_Human0.69168639
149GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69071359
150* MYC_19915707_ChIP-ChIP_AK7_Human0.68589822

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.14351895
2MP0005360_urolithiasis4.65313502
3MP0000920_abnormal_myelination4.15031498
4MP0003806_abnormal_nucleotide_metabolis4.11872911
5MP0005085_abnormal_gallbladder_physiolo3.74054013
6MP0005365_abnormal_bile_salt3.49369642
7MP0008875_abnormal_xenobiotic_pharmacok3.34447390
8MP0003195_calcinosis3.16741878
9MP0003690_abnormal_glial_cell2.72868011
10MP0009840_abnormal_foam_cell2.65771862
11MP0003329_amyloid_beta_deposits2.56714887
12MP0001968_abnormal_touch/_nociception2.48068992
13MP0004043_abnormal_pH_regulation2.39025780
14MP0003880_abnormal_central_pattern2.36916123
15MP0004270_analgesia2.26946266
16MP0005332_abnormal_amino_acid2.25428575
17MP0001501_abnormal_sleep_pattern2.22442074
18MP0003879_abnormal_hair_cell2.19905880
19MP0009780_abnormal_chondrocyte_physiolo2.15848471
20MP0005083_abnormal_biliary_tract2.15432031
21MP0004142_abnormal_muscle_tone2.09892152
22MP0001529_abnormal_vocalization2.08307688
23MP0004885_abnormal_endolymph1.99153767
24MP0005451_abnormal_body_composition1.96235653
25MP0003950_abnormal_plasma_membrane1.94422699
26MP0002272_abnormal_nervous_system1.87476022
27MP0002735_abnormal_chemical_nociception1.84094297
28MP0005646_abnormal_pituitary_gland1.83411820
29MP0001666_abnormal_nutrient_absorption1.80400825
30MP0002736_abnormal_nociception_after1.78204316
31MP0003252_abnormal_bile_duct1.75974671
32MP0000604_amyloidosis1.75732863
33MP0010329_abnormal_lipoprotein_level1.74508067
34MP0003787_abnormal_imprinting1.73656875
35MP0001984_abnormal_olfaction1.71863683
36MP0001905_abnormal_dopamine_level1.71855488
37MP0003122_maternal_imprinting1.69346609
38MP0002118_abnormal_lipid_homeostasis1.68026645
39MP0001486_abnormal_startle_reflex1.66333870
40MP0003634_abnormal_glial_cell1.64437433
41MP0002557_abnormal_social/conspecific_i1.62836246
42MP0002064_seizures1.60448012
43MP0004811_abnormal_neuron_physiology1.59907856
44MP0005584_abnormal_enzyme/coenzyme_acti1.53407523
45MP0003123_paternal_imprinting1.49003465
46MP0002229_neurodegeneration1.47885842
47MP0001485_abnormal_pinna_reflex1.47272040
48MP0002909_abnormal_adrenal_gland1.44910222
49MP0004742_abnormal_vestibular_system1.44292041
50MP0006276_abnormal_autonomic_nervous1.34041960
51MP0008260_abnormal_autophagy1.33525987
52MP0003656_abnormal_erythrocyte_physiolo1.32632736
53MP0002822_catalepsy1.29400596
54MP0003632_abnormal_nervous_system1.24526351
55MP0004381_abnormal_hair_follicle1.24038912
56MP0005410_abnormal_fertilization1.22745176
57MP0005058_abnormal_lysosome_morphology1.22658406
58MP0009745_abnormal_behavioral_response1.21968314
59MP0003633_abnormal_nervous_system1.20297636
60MP0003631_nervous_system_phenotype1.17661955
61MP0004859_abnormal_synaptic_plasticity1.16111333
62MP0003191_abnormal_cellular_cholesterol1.15979618
63MP0003136_yellow_coat_color1.12554241
64MP0005171_absent_coat_pigmentation1.12430336
65MP0001177_atelectasis1.12185235
66MP0003186_abnormal_redox_activity1.11015000
67MP0005423_abnormal_somatic_nervous1.10836171
68MP0000462_abnormal_digestive_system1.08702958
69MP0001661_extended_life_span1.08504235
70MP0005408_hypopigmentation1.08274615
71MP0003635_abnormal_synaptic_transmissio1.08161614
72MP0003868_abnormal_feces_composition1.07958550
73MP0006036_abnormal_mitochondrial_physio1.03168046
74MP0000778_abnormal_nervous_system1.02550145
75MP0002734_abnormal_mechanical_nocicepti1.00940951
76MP0004147_increased_porphyrin_level1.00830870
77MP0008877_abnormal_DNA_methylation0.99399561
78MP0002638_abnormal_pupillary_reflex0.98051848
79MP0004019_abnormal_vitamin_homeostasis0.97672951
80MP0005167_abnormal_blood-brain_barrier0.96294711
81MP0000747_muscle_weakness0.95321999
82MP0000955_abnormal_spinal_cord0.95033967
83MP0002184_abnormal_innervation0.94115057
84MP0001764_abnormal_homeostasis0.93531950
85MP0008872_abnormal_physiological_respon0.92400637
86MP0009046_muscle_twitch0.91779398
87MP0010386_abnormal_urinary_bladder0.91048905
88MP0000609_abnormal_liver_physiology0.90800558
89MP0005551_abnormal_eye_electrophysiolog0.90139472
90MP0002152_abnormal_brain_morphology0.89356443
91MP0002066_abnormal_motor_capabilities/c0.88987625
92MP0000639_abnormal_adrenal_gland0.88868167
93MP0009643_abnormal_urine_homeostasis0.84751613
94MP0002572_abnormal_emotion/affect_behav0.82519359
95MP0001970_abnormal_pain_threshold0.80287065
96MP0002069_abnormal_eating/drinking_beha0.79474589
97MP0002876_abnormal_thyroid_physiology0.78758185
98MP0009765_abnormal_xenobiotic_induced0.77658195
99MP0002882_abnormal_neuron_morphology0.76284896
100MP0005409_darkened_coat_color0.76041395
101MP0002090_abnormal_vision0.76014907
102MP0005319_abnormal_enzyme/_coenzyme0.75840592
103MP0000566_synostosis0.75833632
104MP0001440_abnormal_grooming_behavior0.75762277
105MP0006082_CNS_inflammation0.74521060
106MP0002063_abnormal_learning/memory/cond0.73704017
107MP0001986_abnormal_taste_sensitivity0.73400152
108MP0005636_abnormal_mineral_homeostasis0.73344760
109MP0003172_abnormal_lysosome_physiology0.73189713
110MP0010678_abnormal_skin_adnexa0.72570702
111MP0003121_genomic_imprinting0.70515305
112MP0005535_abnormal_body_temperature0.70482979
113MP0004924_abnormal_behavior0.70463984
114MP0005386_behavior/neurological_phenoty0.70463984
115MP0002733_abnormal_thermal_nociception0.68960864
116MP0001963_abnormal_hearing_physiology0.68045029
117MP0002067_abnormal_sensory_capabilities0.67807943
118MP0008569_lethality_at_weaning0.66972272
119MP0003137_abnormal_impulse_conducting0.65299425
120MP0008874_decreased_physiological_sensi0.64261750
121MP0000579_abnormal_nail_morphology0.61325221
122MP0002138_abnormal_hepatobiliary_system0.60274916
123MP0005645_abnormal_hypothalamus_physiol0.59786117
124MP0002752_abnormal_somatic_nervous0.59457845
125MP0004215_abnormal_myocardial_fiber0.59128620
126MP0000647_abnormal_sebaceous_gland0.58568388
127MP0001502_abnormal_circadian_rhythm0.58128005
128MP0003075_altered_response_to0.57876759
129MP0005195_abnormal_posterior_eye0.57037249
130MP0001346_abnormal_lacrimal_gland0.56329817
131MP0009697_abnormal_copulation0.56236702
132MP0000631_abnormal_neuroendocrine_gland0.52850910
133MP0003283_abnormal_digestive_organ0.51976496
134MP0005379_endocrine/exocrine_gland_phen0.51697189
135MP0001188_hyperpigmentation0.51611796
136MP0003956_abnormal_body_size0.50926220
137MP0006072_abnormal_retinal_apoptosis0.50456548
138MP0005253_abnormal_eye_physiology0.50454161
139MP0004145_abnormal_muscle_electrophysio0.49996582
140MP0002078_abnormal_glucose_homeostasis0.48410112

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.28155071
2Focal seizures (HP:0007359)5.09504417
3Neurofibrillary tangles (HP:0002185)5.06681516
4* Abnormality of aromatic amino acid family metabolism (HP:0004338)4.85715459
5Action tremor (HP:0002345)4.76782058
6Intrahepatic cholestasis (HP:0001406)4.70335247
7Limb dystonia (HP:0002451)4.62059541
8Degeneration of the lateral corticospinal tracts (HP:0002314)4.53351190
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.53351190
10Febrile seizures (HP:0002373)4.50280891
11Abnormality of binocular vision (HP:0011514)4.41214280
12Diplopia (HP:0000651)4.41214280
13Epileptic encephalopathy (HP:0200134)4.41114254
14Atonic seizures (HP:0010819)4.28625240
15Generalized tonic-clonic seizures (HP:0002069)3.86392554
16Abnormal eating behavior (HP:0100738)3.80553653
17Deep venous thrombosis (HP:0002625)3.76329059
18Hyperlipoproteinemia (HP:0010980)3.69911406
19Xanthomatosis (HP:0000991)3.67225535
20Cerebral inclusion bodies (HP:0100314)3.61543700
21Prolonged partial thromboplastin time (HP:0003645)3.56669183
22Torticollis (HP:0000473)3.52076856
23Abnormality of the corticospinal tract (HP:0002492)3.50969971
24Cerebral hypomyelination (HP:0006808)3.39598978
25Visual hallucinations (HP:0002367)3.38797848
26Absence seizures (HP:0002121)3.36446926
27Abnormality of monocarboxylic acid metabolism (HP:0010996)3.27722240
28Dialeptic seizures (HP:0011146)3.26483070
29Focal dystonia (HP:0004373)3.23381666
30Tetraplegia (HP:0002445)3.21306263
31Postural instability (HP:0002172)3.18893105
32Mutism (HP:0002300)3.17986617
33Hypobetalipoproteinemia (HP:0003563)3.17520396
34Abnormality of methionine metabolism (HP:0010901)3.17509886
35Sensory axonal neuropathy (HP:0003390)3.13866742
36Peripheral hypomyelination (HP:0007182)3.11889934
37Hemiparesis (HP:0001269)3.10900191
38Abnormality of aspartate family amino acid metabolism (HP:0010899)3.02774658
39Anxiety (HP:0000739)3.00148496
40Craniofacial dystonia (HP:0012179)2.99690474
41Parakeratosis (HP:0001036)2.95052221
42Progressive cerebellar ataxia (HP:0002073)2.94040850
43Spastic paraparesis (HP:0002313)2.93725839
44Leukodystrophy (HP:0002415)2.91643031
45Status epilepticus (HP:0002133)2.91307024
46Onion bulb formation (HP:0003383)2.91048504
47Delusions (HP:0000746)2.90689160
48Rigidity (HP:0002063)2.89957749
49Hyperammonemia (HP:0001987)2.88388218
50Abnormality of serine family amino acid metabolism (HP:0010894)2.87759487
51Abnormality of glycine metabolism (HP:0010895)2.87759487
52Bradykinesia (HP:0002067)2.84213622
53Spastic gait (HP:0002064)2.82733824
54Supranuclear gaze palsy (HP:0000605)2.79383832
55Increased serum pyruvate (HP:0003542)2.78970902
56Abnormality of glycolysis (HP:0004366)2.78970902
57Akinesia (HP:0002304)2.78428834
58Ketosis (HP:0001946)2.75179823
59Epileptiform EEG discharges (HP:0011182)2.74631097
60Truncal ataxia (HP:0002078)2.73254438
61Papilledema (HP:0001085)2.72801609
62Impaired vibration sensation in the lower limbs (HP:0002166)2.71180220
63Axonal loss (HP:0003447)2.71163799
64Fat malabsorption (HP:0002630)2.70583904
65Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.70496912
66Myokymia (HP:0002411)2.67858831
67Cerebral hemorrhage (HP:0001342)2.67050872
68Urinary urgency (HP:0000012)2.66731057
69Depression (HP:0000716)2.65914433
70Intention tremor (HP:0002080)2.63997994
71Abnormal auditory evoked potentials (HP:0006958)2.63202631
72Neuronal loss in central nervous system (HP:0002529)2.59312096
73Hyperglycinemia (HP:0002154)2.59197272
74Hemiplegia (HP:0002301)2.56778328
75Polyphagia (HP:0002591)2.56321230
76Urinary bladder sphincter dysfunction (HP:0002839)2.53546243
77Lower limb muscle weakness (HP:0007340)2.52238622
78* Choreoathetosis (HP:0001266)2.49420297
79EEG with generalized epileptiform discharges (HP:0011198)2.49085223
80Abnormality of sulfur amino acid metabolism (HP:0004339)2.47843696
81Clonus (HP:0002169)2.46361626
82Dysmetria (HP:0001310)2.45821009
83Scanning speech (HP:0002168)2.44929493
84Abnormal gallbladder physiology (HP:0012438)2.43594186
85Cholecystitis (HP:0001082)2.43594186
86Annular pancreas (HP:0001734)2.43418785
87Poor eye contact (HP:0000817)2.41015118
88Hypophosphatemic rickets (HP:0004912)2.40580804
89Paraparesis (HP:0002385)2.38540527
90CNS hypomyelination (HP:0003429)2.38399135
91Steatorrhea (HP:0002570)2.37834753
92Conjugated hyperbilirubinemia (HP:0002908)2.35586989
93Complement deficiency (HP:0004431)2.35553472
94Pheochromocytoma (HP:0002666)2.35388892
95Cerebral edema (HP:0002181)2.34662044
96Amblyopia (HP:0000646)2.34406913
97Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.33077195
98Hypsarrhythmia (HP:0002521)2.32741779
99Epidermoid cyst (HP:0200040)2.31540319
100Ankle clonus (HP:0011448)2.31143938
101Acute encephalopathy (HP:0006846)2.30859774
102Dysdiadochokinesis (HP:0002075)2.29732157
103Spastic tetraparesis (HP:0001285)2.28930069
104Delayed CNS myelination (HP:0002188)2.27511187
105Slow saccadic eye movements (HP:0000514)2.27268235
106Amyloidosis (HP:0011034)2.27100984
107Hypoglycemic coma (HP:0001325)2.26792655
108Increased circulating renin level (HP:0000848)2.25034971
1093-Methylglutaconic aciduria (HP:0003535)2.24568973
110Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.23456633
111Retinal dysplasia (HP:0007973)2.23261978
112Abnormality of fatty-acid metabolism (HP:0004359)2.22667608
113Apathy (HP:0000741)2.21056881
114Termporal pattern (HP:0011008)2.18222104
115Insidious onset (HP:0003587)2.18222104
116Alacrima (HP:0000522)2.17688237
117Hypokalemic alkalosis (HP:0001949)2.15863706
118Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.14979040
119Alkalosis (HP:0001948)2.14024459
120Sleep apnea (HP:0010535)2.12881780
121Diminished movement (HP:0002374)2.12779676
122Diminished motivation (HP:0000745)2.10429157
123Methylmalonic acidemia (HP:0002912)2.09828368
124Joint hemorrhage (HP:0005261)2.09709293
125Postural tremor (HP:0002174)2.08249545
126Vascular calcification (HP:0004934)2.06398841
127Muscular hypotonia of the trunk (HP:0008936)2.05747296
128Abnormality of glutamine family amino acid metabolism (HP:0010902)2.05622389
129Abnormality of serum amino acid levels (HP:0003112)2.04974330
130Metabolic alkalosis (HP:0200114)2.04565606
131Renal Fanconi syndrome (HP:0001994)2.04340722
132Hypolipoproteinemia (HP:0010981)2.04269566
133Neuroendocrine neoplasm (HP:0100634)2.04160819
134Lethargy (HP:0001254)2.03419374
135Opisthotonus (HP:0002179)2.02265810
136Abnormal gallbladder morphology (HP:0012437)2.00106290
137Hypokinesia (HP:0002375)1.99949299
138Rapidly progressive (HP:0003678)1.98046271
139Hyperglycinuria (HP:0003108)1.98025760
140Obstructive sleep apnea (HP:0002870)1.96241670
141Dicarboxylic aciduria (HP:0003215)1.96150922
142Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96150922
143Peripheral demyelination (HP:0011096)1.95740025
144Abnormality of the common coagulation pathway (HP:0010990)1.95589600
145Bundle branch block (HP:0011710)1.95188907
146Stridor (HP:0010307)1.93123975
147Abnormal social behavior (HP:0012433)1.92853537
148Impaired social interactions (HP:0000735)1.92853537
149Impaired vibratory sensation (HP:0002495)1.91773172
150Hyperbilirubinemia (HP:0002904)1.90850215
151Delayed myelination (HP:0012448)1.90764444
152Morphological abnormality of the pyramidal tract (HP:0002062)1.90170858
153Abnormality of the lower motor neuron (HP:0002366)1.90061302
154Ketoacidosis (HP:0001993)1.89582312
155Confusion (HP:0001289)1.89255061
156Split foot (HP:0001839)1.89217784
157Metabolic acidosis (HP:0001942)1.89182892
158Retinal atrophy (HP:0001105)1.88774330
159Hepatosplenomegaly (HP:0001433)1.88330210
160Rickets (HP:0002748)1.88176519
161Poor speech (HP:0002465)1.88139908
162Hypoglycemic seizures (HP:0002173)1.87497085
163Fetal akinesia sequence (HP:0001989)1.81168807
164Abnormality of the periventricular white matter (HP:0002518)1.81157592
165Abnormality of saccadic eye movements (HP:0000570)1.80402489
166Incomplete penetrance (HP:0003829)1.78103020
167Dysarthria (HP:0001260)1.77218626
168Ventricular fibrillation (HP:0001663)1.74981656
169Dementia (HP:0000726)1.74836587
170Insomnia (HP:0100785)1.73899937
171Impaired smooth pursuit (HP:0007772)1.73412208
172Psychosis (HP:0000709)1.72061943
173Poor suck (HP:0002033)1.71243465
174Heart block (HP:0012722)1.71212995
175Abnormality of ocular smooth pursuit (HP:0000617)1.69678917
176Gait ataxia (HP:0002066)1.68321156
177Spastic tetraplegia (HP:0002510)1.68208215
178Gaze-evoked nystagmus (HP:0000640)1.67221014

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.96970550
2OXSR14.69264761
3NTRK33.88018488
4PKN12.91909036
5BCKDK2.71892545
6WNK42.71888241
7EPHB12.64319101
8MAP3K92.63879150
9CDK192.58317219
10FGFR22.57099563
11BCR2.51097753
12MET2.47679262
13PBK2.39744983
14MAPKAPK52.38369992
15TESK22.25493807
16CSNK1G32.23651248
17MINK12.12727532
18CAMKK12.12087655
19CSNK1A1L2.04186900
20PLK22.01665385
21LIMK11.99589627
22UHMK11.99045357
23NTRK11.96177897
24GRK51.91969802
25CSNK1G11.73908518
26WNK11.70380232
27CSNK1G21.70323891
28DAPK11.56887694
29SGK2231.51557435
30SGK4941.51557435
31MAPK151.48269044
32CAMK11.39382329
33NEK61.31015839
34MAPK131.28671048
35TESK11.27074279
36ROCK21.22542994
37EPHA41.19710544
38LATS21.19032815
39CAMKK21.15795173
40ARAF1.15396438
41* CAMK2B1.14509188
42PINK11.13630657
43INSRR1.12588365
44RIPK11.10636467
45PAK61.08601062
46TNIK1.07576478
47ERBB41.05383681
48DYRK21.00692833
49MAP3K121.00372263
50ICK0.99777719
51* CAMK2G0.96830156
52DYRK1A0.95110882
53PHKG10.92537687
54PHKG20.92537687
55MAP3K110.91633576
56ALK0.91567508
57KSR20.91228354
58* CAMK2D0.89879411
59FGR0.88572922
60PNCK0.86408274
61PRPF4B0.86129382
62PRKD10.84806374
63PDPK10.83273628
64PRKCQ0.81003195
65CDK50.80032413
66PAK30.79373202
67CDK140.78836693
68CLK10.76423645
69BRSK10.76104816
70DAPK20.73845899
71SGK10.73416278
72MARK10.72693956
73STK380.72679177
74MAPK100.70665986
75MARK20.70282369
76MAP2K60.69956891
77MUSK0.69713196
78MAP3K40.69561263
79STK160.68063037
80CDK150.66989003
81TNK20.66876701
82TYRO30.65155290
83* CAMK2A0.64181655
84LMTK20.63654923
85MAP2K20.63649624
86RPS6KA30.63005443
87CDK180.60733459
88CDK11A0.59521819
89GSK3A0.58872678
90SGK20.58599730
91BMPR1B0.57963716
92MAP3K130.57751074
93DAPK30.57375916
94ABL20.56764567
95PRKCH0.56348770
96PRKCE0.56191539
97CASK0.55098261
98SIK10.53901831
99IRAK20.53353288
100MST40.52867168
101CCNB10.51356233
102SIK20.48845510
103MAP2K40.48564911
104BRAF0.47994249
105WNK30.47044768
106MAP3K20.47001424
107RIPK40.46891255
108CSNK1A10.45932904
109PRKD30.45924616
110CAMK40.45642851
111PRKCA0.45594781
112SCYL20.45207088
113PDK10.44439557
114PRKCZ0.44220514
115BMPR20.44218791
116FYN0.43779160
117PRKG10.43447653
118SGK30.38545333
119STK110.38169799
120PIK3CG0.38063972
121BLK0.37762570
122HIPK20.37724829
123NTRK20.37324025
124CSNK1D0.35425997
125PRKACA0.34719790
126TRPM70.34537004
127MAP2K70.34430385
128ROCK10.33179885
129TAOK30.32464782
130RPS6KA50.31326967
131MOS0.31320576
132RAF10.31141888
133ITK0.29124873
134ADRBK20.28223879
135PRKG20.28209126
136MAP3K10.26203711
137PRKCG0.25806150
138MAPK120.25302457
139MAPK70.24732863

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.48626985
2Nicotine addiction_Homo sapiens_hsa050333.65532957
3Fatty acid elongation_Homo sapiens_hsa000623.33511861
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.27612643
5Primary bile acid biosynthesis_Homo sapiens_hsa001203.11857196
6Steroid biosynthesis_Homo sapiens_hsa001002.95013855
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.85503274
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.82329018
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.78493488
10Amphetamine addiction_Homo sapiens_hsa050312.69839516
11Insulin secretion_Homo sapiens_hsa049112.53976613
12Histidine metabolism_Homo sapiens_hsa003402.39542886
13Long-term potentiation_Homo sapiens_hsa047202.38813920
14Butanoate metabolism_Homo sapiens_hsa006502.38540430
15Circadian entrainment_Homo sapiens_hsa047132.36533838
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32477229
17Sulfur metabolism_Homo sapiens_hsa009202.21597302
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.20272124
19Arginine biosynthesis_Homo sapiens_hsa002202.18042015
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.17061257
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.09104227
22Dopaminergic synapse_Homo sapiens_hsa047282.03502924
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.93997416
24Vitamin B6 metabolism_Homo sapiens_hsa007501.92877797
25Propanoate metabolism_Homo sapiens_hsa006401.91365690
26Tryptophan metabolism_Homo sapiens_hsa003801.85269487
27Gastric acid secretion_Homo sapiens_hsa049711.84970871
28Peroxisome_Homo sapiens_hsa041461.82397831
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.78684576
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76213759
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.72413375
32Fatty acid degradation_Homo sapiens_hsa000711.68675147
33Fatty acid metabolism_Homo sapiens_hsa012121.62919210
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.55133657
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.52184588
36Salivary secretion_Homo sapiens_hsa049701.51339526
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50870174
38Arginine and proline metabolism_Homo sapiens_hsa003301.50517438
39Chemical carcinogenesis_Homo sapiens_hsa052041.47478727
40Complement and coagulation cascades_Homo sapiens_hsa046101.47314118
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47264338
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44039294
43beta-Alanine metabolism_Homo sapiens_hsa004101.39384067
44Pyruvate metabolism_Homo sapiens_hsa006201.31555812
45Ether lipid metabolism_Homo sapiens_hsa005651.31032133
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.30717252
47Renin secretion_Homo sapiens_hsa049241.26588748
48Protein export_Homo sapiens_hsa030601.24212067
49Pentose and glucuronate interconversions_Homo sapiens_hsa000401.23430074
50Tyrosine metabolism_Homo sapiens_hsa003501.22748044
51Cholinergic synapse_Homo sapiens_hsa047251.22474711
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19384340
53Retinol metabolism_Homo sapiens_hsa008301.19220850
54PPAR signaling pathway_Homo sapiens_hsa033201.17616198
55Oxytocin signaling pathway_Homo sapiens_hsa049211.15729363
56Calcium signaling pathway_Homo sapiens_hsa040201.15707410
57Oxidative phosphorylation_Homo sapiens_hsa001901.12732650
58Bile secretion_Homo sapiens_hsa049761.10297043
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09863332
60cAMP signaling pathway_Homo sapiens_hsa040241.09546145
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.04252060
62Phenylalanine metabolism_Homo sapiens_hsa003601.03151360
63Maturity onset diabetes of the young_Homo sapiens_hsa049501.01434355
64Glutathione metabolism_Homo sapiens_hsa004800.95868587
65Taste transduction_Homo sapiens_hsa047420.95062512
66Linoleic acid metabolism_Homo sapiens_hsa005910.93405944
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92879130
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89930860
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89057770
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87142681
71Parkinsons disease_Homo sapiens_hsa050120.85010406
72Oocyte meiosis_Homo sapiens_hsa041140.83926127
73Olfactory transduction_Homo sapiens_hsa047400.82091691
74ABC transporters_Homo sapiens_hsa020100.81503446
75Biosynthesis of amino acids_Homo sapiens_hsa012300.80367453
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75526053
77Fat digestion and absorption_Homo sapiens_hsa049750.75029948
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.74415747
79Vitamin digestion and absorption_Homo sapiens_hsa049770.73760441
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70513397
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70349416
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.69727572
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69652174
84Sulfur relay system_Homo sapiens_hsa041220.69499793
85Staphylococcus aureus infection_Homo sapiens_hsa051500.68926412
86Phototransduction_Homo sapiens_hsa047440.68227759
87GnRH signaling pathway_Homo sapiens_hsa049120.67906405
88Alzheimers disease_Homo sapiens_hsa050100.67768667
89Carbon metabolism_Homo sapiens_hsa012000.67131806
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67121059
91Thyroid hormone synthesis_Homo sapiens_hsa049180.66819595
92Selenocompound metabolism_Homo sapiens_hsa004500.66219852
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66156298
94Caffeine metabolism_Homo sapiens_hsa002320.64645774
95* Metabolic pathways_Homo sapiens_hsa011000.64556370
96GABAergic synapse_Homo sapiens_hsa047270.63942072
97Glucagon signaling pathway_Homo sapiens_hsa049220.62892344
98Mineral absorption_Homo sapiens_hsa049780.62353600
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59611650
100Estrogen signaling pathway_Homo sapiens_hsa049150.57454236
101Sphingolipid metabolism_Homo sapiens_hsa006000.55686741
102Gap junction_Homo sapiens_hsa045400.55553630
103Starch and sucrose metabolism_Homo sapiens_hsa005000.53897146
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53883078
105Melanogenesis_Homo sapiens_hsa049160.53765549
106Circadian rhythm_Homo sapiens_hsa047100.53686829
107Glycerolipid metabolism_Homo sapiens_hsa005610.51506191
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49994342
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.49812922
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48718346
111* Folate biosynthesis_Homo sapiens_hsa007900.47910567
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44711728
113Prion diseases_Homo sapiens_hsa050200.42589136
114Glioma_Homo sapiens_hsa052140.42028190
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41557546
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.41318101
117Fatty acid biosynthesis_Homo sapiens_hsa000610.39792982
118Arachidonic acid metabolism_Homo sapiens_hsa005900.33950524
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.33022858
120Cocaine addiction_Homo sapiens_hsa050300.32351850
121Type II diabetes mellitus_Homo sapiens_hsa049300.31978013
122Inositol phosphate metabolism_Homo sapiens_hsa005620.31772009
123Glutamatergic synapse_Homo sapiens_hsa047240.31545269
124Lysosome_Homo sapiens_hsa041420.30077264
125Endocytosis_Homo sapiens_hsa041440.29879220
126Ras signaling pathway_Homo sapiens_hsa040140.29708620
127Collecting duct acid secretion_Homo sapiens_hsa049660.28151858
128Serotonergic synapse_Homo sapiens_hsa047260.25489510
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25223126
130Vibrio cholerae infection_Homo sapiens_hsa051100.25182522
131Axon guidance_Homo sapiens_hsa043600.25023641
132Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22724745
133Regulation of autophagy_Homo sapiens_hsa041400.21565163
134Huntingtons disease_Homo sapiens_hsa050160.19977924
135Pentose phosphate pathway_Homo sapiens_hsa000300.18139728
136Morphine addiction_Homo sapiens_hsa050320.15139001
137Ovarian steroidogenesis_Homo sapiens_hsa049130.14304152
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12030147
139Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.11650189
140Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11280996
141Pancreatic secretion_Homo sapiens_hsa049720.10052230
142Synaptic vesicle cycle_Homo sapiens_hsa047210.09418127
143Cardiac muscle contraction_Homo sapiens_hsa042600.09364440
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.07773388
145Long-term depression_Homo sapiens_hsa047300.07130477
146Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.06715461

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