QARS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)4.74128485
2formation of translation preinitiation complex (GO:0001731)4.52134222
3proline biosynthetic process (GO:0006561)4.16703389
4DNA unwinding involved in DNA replication (GO:0006268)4.15727697
5maturation of SSU-rRNA (GO:0030490)4.10331210
6protein localization to chromosome, centromeric region (GO:0071459)4.03266028
7ribosomal small subunit assembly (GO:0000028)4.01840054
8nucleobase biosynthetic process (GO:0046112)3.91306523
9mitotic nuclear envelope disassembly (GO:0007077)3.78247524
10viral transcription (GO:0019083)3.76903877
11IMP biosynthetic process (GO:0006188)3.76707048
12mitotic metaphase plate congression (GO:0007080)3.75993888
13folic acid-containing compound biosynthetic process (GO:0009396)3.74090506
14DNA strand elongation involved in DNA replication (GO:0006271)3.72792043
15translational termination (GO:0006415)3.72022549
16DNA replication initiation (GO:0006270)3.69491277
17nuclear pore organization (GO:0006999)3.62887687
18purine nucleobase biosynthetic process (GO:0009113)3.58676269
19DNA strand elongation (GO:0022616)3.55096041
20mitotic chromosome condensation (GO:0007076)3.53156870
21ribosome assembly (GO:0042255)3.51639065
22nuclear envelope disassembly (GO:0051081)3.48363907
23membrane disassembly (GO:0030397)3.48363907
24translational initiation (GO:0006413)3.46494778
25translational elongation (GO:0006414)3.44894231
26ribosomal large subunit biogenesis (GO:0042273)3.42613596
27DNA replication-dependent nucleosome organization (GO:0034723)3.38523427
28DNA replication-dependent nucleosome assembly (GO:0006335)3.38523427
29metaphase plate congression (GO:0051310)3.36851765
30nuclear pore complex assembly (GO:0051292)3.35784760
31COPI coating of Golgi vesicle (GO:0048205)3.33782950
32Golgi transport vesicle coating (GO:0048200)3.33782950
33regulation of spindle organization (GO:0090224)3.32453679
34establishment of integrated proviral latency (GO:0075713)3.32253178
35IMP metabolic process (GO:0046040)3.31980134
36telomere maintenance via semi-conservative replication (GO:0032201)3.31900829
37mitotic sister chromatid segregation (GO:0000070)3.31569404
38pinocytosis (GO:0006907)3.28627217
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.28604206
40protein targeting to membrane (GO:0006612)3.28374729
41ribosomal small subunit biogenesis (GO:0042274)3.28196046
42DNA replication checkpoint (GO:0000076)3.26162184
43regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23603932
44ribonucleoprotein complex biogenesis (GO:0022613)3.23061910
45ribosome biogenesis (GO:0042254)3.19999797
46sister chromatid segregation (GO:0000819)3.12807045
47DNA topological change (GO:0006265)3.12697394
48protein-DNA complex disassembly (GO:0032986)3.12228858
49nucleosome disassembly (GO:0006337)3.12228858
50spliceosomal tri-snRNP complex assembly (GO:0000244)3.11216328
51SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.11162757
52pentose-phosphate shunt (GO:0006098)3.09949899
53DNA geometric change (GO:0032392)3.08813398
54DNA duplex unwinding (GO:0032508)3.07717278
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.05890086
56negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.05622759
57heterochromatin organization (GO:0070828)3.01673175
58protein targeting to ER (GO:0045047)3.00866540
59cotranslational protein targeting to membrane (GO:0006613)2.99694854
60establishment of chromosome localization (GO:0051303)2.99573561
61NADPH regeneration (GO:0006740)2.98751791
62telomere maintenance via recombination (GO:0000722)2.98581207
63somatic hypermutation of immunoglobulin genes (GO:0016446)2.96515962
64somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96515962
65folic acid metabolic process (GO:0046655)2.96116310
66regulation of posttranscriptional gene silencing (GO:0060147)2.95792743
67regulation of gene silencing by miRNA (GO:0060964)2.95792743
68regulation of gene silencing by RNA (GO:0060966)2.95792743
69translation (GO:0006412)2.94663735
70mitotic recombination (GO:0006312)2.93888764
71NADH metabolic process (GO:0006734)2.93177722
72proline metabolic process (GO:0006560)2.92900085
73protein localization to chromosome (GO:0034502)2.92519247
74peptidyl-arginine omega-N-methylation (GO:0035247)2.92131640
75cellular protein complex disassembly (GO:0043624)2.91942450
76ncRNA 3-end processing (GO:0043628)2.89572359
77telomere maintenance via telomere lengthening (GO:0010833)2.89254389
78protein K6-linked ubiquitination (GO:0085020)2.88391175
79protein maturation by protein folding (GO:0022417)2.88090885
80viral life cycle (GO:0019058)2.87554283
81kinetochore organization (GO:0051383)2.86082020
82establishment of protein localization to endoplasmic reticulum (GO:0072599)2.86023610
83CENP-A containing nucleosome assembly (GO:0034080)2.82303236
84chromatin remodeling at centromere (GO:0031055)2.81041774
85positive regulation of chromosome segregation (GO:0051984)2.80072530
86nuclear envelope organization (GO:0006998)2.79278113
87DNA packaging (GO:0006323)2.78809528
88cellular hyperosmotic response (GO:0071474)2.78743844
89protein localization to endoplasmic reticulum (GO:0070972)2.77341630
90regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.76934239
91rRNA processing (GO:0006364)2.76883738
92DNA replication-independent nucleosome assembly (GO:0006336)2.75819516
93DNA replication-independent nucleosome organization (GO:0034724)2.75819516
94protein complex disassembly (GO:0043241)2.74322953
95regulation of translational fidelity (GO:0006450)2.73531184
96regulation of RNA export from nucleus (GO:0046831)2.73467975
97regulation of nuclear cell cycle DNA replication (GO:0033262)2.71370563
98regulation of mitotic spindle organization (GO:0060236)2.68921024
99RNA stabilization (GO:0043489)2.68602072
100mRNA stabilization (GO:0048255)2.68602072
101rRNA metabolic process (GO:0016072)2.68034398
102DNA conformation change (GO:0071103)2.65330651
103regulation of translation in response to stress (GO:0043555)2.63813410
104pore complex assembly (GO:0046931)2.62795664
105nuclear-transcribed mRNA catabolic process (GO:0000956)2.62586059
106negative regulation of RNA splicing (GO:0033119)2.61787130
107planar cell polarity pathway involved in neural tube closure (GO:0090179)2.61707898
108regulation of histone H3-K9 methylation (GO:0051570)2.61648963
109paraxial mesoderm development (GO:0048339)2.61243189
110chromatin assembly or disassembly (GO:0006333)2.60749642
111establishment of viral latency (GO:0019043)2.60184265
112nucleotide-excision repair, DNA gap filling (GO:0006297)2.59990153
113attachment of spindle microtubules to kinetochore (GO:0008608)2.59651641
114tricarboxylic acid metabolic process (GO:0072350)2.59380851
115myeloid cell homeostasis (GO:0002262)2.59064579
116negative regulation of mRNA processing (GO:0050686)2.57608948
117positive regulation of SMAD protein import into nucleus (GO:0060391)2.57273518
118glucose catabolic process (GO:0006007)2.56884751
119meiotic chromosome segregation (GO:0045132)2.56729203
1203-UTR-mediated mRNA stabilization (GO:0070935)2.56361898
121kinetochore assembly (GO:0051382)2.55781091
122regulation of chromosome segregation (GO:0051983)2.55075459
123spindle checkpoint (GO:0031577)2.55054458
124histone arginine methylation (GO:0034969)2.54991618
125macromolecular complex disassembly (GO:0032984)2.54688742
126mismatch repair (GO:0006298)2.53523935
127interferon-gamma secretion (GO:0072643)2.53008008
128regulation of sister chromatid cohesion (GO:0007063)2.52600010
129chromosome condensation (GO:0030261)2.52369618
130RNA catabolic process (GO:0006401)2.52128698
131regulation of mammary gland epithelial cell proliferation (GO:0033599)2.51602970
132mRNA catabolic process (GO:0006402)2.51495542
133L-serine metabolic process (GO:0006563)2.51394083
134chromatin assembly (GO:0031497)2.50407861
135negative regulation of mRNA metabolic process (GO:1903312)2.49958240
136negative regulation of DNA repair (GO:0045738)2.48367179
137rRNA modification (GO:0000154)2.46894257
138poly(A)+ mRNA export from nucleus (GO:0016973)2.44536651
139mitochondrial fusion (GO:0008053)2.43335616
140protein retention in ER lumen (GO:0006621)2.42065296
141negative regulation of erythrocyte differentiation (GO:0045647)2.41836168
142tricarboxylic acid cycle (GO:0006099)2.41811963
143regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.40425065
144maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.38899035
145peptidyl-arginine N-methylation (GO:0035246)2.38488842
146peptidyl-arginine methylation (GO:0018216)2.38488842

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.91715042
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.05716252
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.84005086
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.26639497
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.11833576
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.04081586
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86780989
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48763537
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.39896672
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39831286
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.26998814
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.25061836
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21536529
14AR_21909140_ChIP-Seq_LNCAP_Human2.20612433
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.09484137
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.09098734
17XRN2_22483619_ChIP-Seq_HELA_Human2.07453555
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06782369
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.04287530
20MYC_22102868_ChIP-Seq_BL_Human1.97107883
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96196652
22TP63_17297297_ChIP-ChIP_HaCaT_Human1.91619509
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87683344
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83722068
25NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81784753
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79860910
27VDR_23849224_ChIP-Seq_CD4+_Human1.78175821
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77924254
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.75591250
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.69574769
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69573108
32FOXP3_21729870_ChIP-Seq_TREG_Human1.67930941
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67821080
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.65524166
35DCP1A_22483619_ChIP-Seq_HELA_Human1.64792839
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63282740
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62514816
38CIITA_25753668_ChIP-Seq_RAJI_Human1.62182911
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61020216
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.56617001
41GABP_19822575_ChIP-Seq_HepG2_Human1.55091256
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54247399
43TTF2_22483619_ChIP-Seq_HELA_Human1.53588034
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53076091
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.52498813
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51188292
47LXR_22292898_ChIP-Seq_THP-1_Human1.50852135
48KDM5A_27292631_Chip-Seq_BREAST_Human1.50526143
49SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.44165840
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42914198
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41009348
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.39035058
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38903123
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36948558
55RACK7_27058665_Chip-Seq_MCF-7_Human1.33716707
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.31088256
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.31088256
58KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.31088256
59* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30489152
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30313314
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27786981
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.26718281
63* VDR_21846776_ChIP-Seq_THP-1_Human1.25050391
64ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.24482740
65ELK1_19687146_ChIP-ChIP_HELA_Human1.24097872
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23139210
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22590888
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22450729
69RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21238400
70KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19918667
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19533523
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19045483
73* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18055626
74CLOCK_20551151_ChIP-Seq_293T_Human1.16903258
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14231134
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14064709
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14026279
78NCOR1_26117541_ChIP-Seq_K562_Human1.13866131
79TFEB_21752829_ChIP-Seq_HELA_Human1.13798546
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.13643401
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13305994
82TCF7_22412390_ChIP-Seq_EML_Mouse1.13179524
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12511552
84* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12116247
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11440051
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07959969
87* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07392052
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07094302
89RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07027543
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07019194
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04104796
92TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03936617
93SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02928992
94NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02384802
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02003741
96P68_20966046_ChIP-Seq_HELA_Human1.00981918
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00302314
98* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99527941
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98805992
100PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98242412
101SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98074683
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98074579
103E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97246580
104NANOG_21062744_ChIP-ChIP_HESCs_Human0.95571345
105E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95249813
106SPI1_23547873_ChIP-Seq_NB4_Human0.95094943
107SRF_21415370_ChIP-Seq_HL-1_Mouse0.94672423
108GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94365153
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93708728
110SA1_27219007_Chip-Seq_ERYTHROID_Human0.93377765
111KDM2B_26808549_Chip-Seq_DND41_Human0.92459572
112* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92282189
113CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91594252
114MAF_26560356_Chip-Seq_TH1_Human0.91529730
115BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88789773
116NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.88095260
117TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87688619
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85857073
119HIF1A_21447827_ChIP-Seq_MCF-7_Human0.83983780
120ATF3_27146783_Chip-Seq_COLON_Human0.83774127
121* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83378847
122ZNF263_19887448_ChIP-Seq_K562_Human0.83000203
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82171942
124CHD1_26751641_Chip-Seq_LNCaP_Human0.81348227
125CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80443222
126SOX2_18692474_ChIP-Seq_MEFs_Mouse0.79270745
127MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.78927686
128UTX_26944678_Chip-Seq_JUKART_Human0.78792427
129OCT4_18692474_ChIP-Seq_MEFs_Mouse0.78529862

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.13645065
2MP0003111_abnormal_nucleus_morphology3.51264350
3MP0004957_abnormal_blastocyst_morpholog3.51177722
4MP0010094_abnormal_chromosome_stability3.40338355
5MP0008057_abnormal_DNA_replication3.20215766
6MP0003077_abnormal_cell_cycle3.10685037
7MP0010352_gastrointestinal_tract_polyps3.01872339
8MP0009379_abnormal_foot_pigmentation2.33111457
9MP0008058_abnormal_DNA_repair2.29242142
10MP0008007_abnormal_cellular_replicative2.27364567
11MP0002396_abnormal_hematopoietic_system2.18549722
12MP0001730_embryonic_growth_arrest2.00200515
13MP0005058_abnormal_lysosome_morphology1.96853751
14MP0000490_abnormal_crypts_of1.90142064
15MP0000350_abnormal_cell_proliferation1.85039081
16MP0003123_paternal_imprinting1.82141392
17MP0008932_abnormal_embryonic_tissue1.78138930
18MP0003705_abnormal_hypodermis_morpholog1.72894563
19MP0010307_abnormal_tumor_latency1.68740240
20MP0001672_abnormal_embryogenesis/_devel1.66567371
21MP0005380_embryogenesis_phenotype1.66567371
22MP0001661_extended_life_span1.66241153
23MP0004264_abnormal_extraembryonic_tissu1.61247550
24MP0000566_synostosis1.59207094
25MP0003984_embryonic_growth_retardation1.53579727
26MP0002088_abnormal_embryonic_growth/wei1.50131483
27MP0003566_abnormal_cell_adhesion1.47197554
28MP0001697_abnormal_embryo_size1.46876263
29MP0003941_abnormal_skin_development1.44632529
30MP0004808_abnormal_hematopoietic_stem1.44136189
31MP0005076_abnormal_cell_differentiation1.42831063
32MP0004233_abnormal_muscle_weight1.41182910
33MP0003786_premature_aging1.40852257
34MP0002085_abnormal_embryonic_tissue1.40735411
35MP0002080_prenatal_lethality1.39441272
36MP0008260_abnormal_autophagy1.39318001
37MP0008877_abnormal_DNA_methylation1.37067372
38MP0002086_abnormal_extraembryonic_tissu1.36823956
39MP0000537_abnormal_urethra_morphology1.35070231
40MP0002084_abnormal_developmental_patter1.34375223
41MP0003567_abnormal_fetal_cardiomyocyte1.34109349
42MP0004197_abnormal_fetal_growth/weight/1.33898103
43MP0009333_abnormal_splenocyte_physiolog1.31236061
44MP0002019_abnormal_tumor_incidence1.28815063
45MP0005257_abnormal_intraocular_pressure1.27556872
46MP0010030_abnormal_orbit_morphology1.26955493
47MP0004858_abnormal_nervous_system1.25811019
48MP0003718_maternal_effect1.25794451
49MP0005408_hypopigmentation1.21272119
50MP0008438_abnormal_cutaneous_collagen1.18210603
51MP0010630_abnormal_cardiac_muscle1.17916834
52MP0004272_abnormal_basement_membrane1.17609041
53MP0000313_abnormal_cell_death1.15582270
54MP0001849_ear_inflammation1.14266562
55MP0000678_abnormal_parathyroid_gland1.12726284
56MP0000858_altered_metastatic_potential1.11927263
57MP0005397_hematopoietic_system_phenotyp1.11899530
58MP0001545_abnormal_hematopoietic_system1.11899530
59MP0005023_abnormal_wound_healing1.11660086
60MP0005666_abnormal_adipose_tissue1.10632803
61MP0003763_abnormal_thymus_physiology1.10111515
62MP0010234_abnormal_vibrissa_follicle1.09567506
63MP0009278_abnormal_bone_marrow1.09303195
64MP0000751_myopathy1.07206993
65MP0005360_urolithiasis1.05785469
66MP0003890_abnormal_embryonic-extraembry1.02955311
67MP0005501_abnormal_skin_physiology1.02634059
68MP0002697_abnormal_eye_size0.99413725
69MP0009053_abnormal_anal_canal0.99078353
70MP0003315_abnormal_perineum_morphology0.98063730
71MP0005330_cardiomyopathy0.96797637
72MP0002796_impaired_skin_barrier0.94981562
73MP0002111_abnormal_tail_morphology0.93804568
74MP0003806_abnormal_nucleotide_metabolis0.93592203
75MP0002722_abnormal_immune_system0.92409470
76MP0000477_abnormal_intestine_morphology0.91970168
77MP0000383_abnormal_hair_follicle0.91781674
78MP0000703_abnormal_thymus_morphology0.90455857
79MP0002089_abnormal_postnatal_growth/wei0.90302803
80MP0002398_abnormal_bone_marrow0.89211232
81MP0001216_abnormal_epidermal_layer0.89016609
82MP0008789_abnormal_olfactory_epithelium0.88449151
83MP0003385_abnormal_body_wall0.87135894
84MP0000689_abnormal_spleen_morphology0.86541971
85MP0002132_abnormal_respiratory_system0.86163688
86MP0001293_anophthalmia0.85810577
87MP0005451_abnormal_body_composition0.84901452
88MP0003453_abnormal_keratinocyte_physiol0.84499425
89MP0004087_abnormal_muscle_fiber0.84476552
90MP0010155_abnormal_intestine_physiology0.82755062
91MP0001873_stomach_inflammation0.81770058
92MP0002254_reproductive_system_inflammat0.81499068
93MP0002210_abnormal_sex_determination0.80668151
94MP0006035_abnormal_mitochondrial_morpho0.79958963
95MP0009672_abnormal_birth_weight0.78449304
96MP0009703_decreased_birth_body0.77946201
97MP0002060_abnormal_skin_morphology0.77796634
98MP0003878_abnormal_ear_physiology0.77317192
99MP0005377_hearing/vestibular/ear_phenot0.77317192
100MP0002249_abnormal_larynx_morphology0.77080705
101MP0000467_abnormal_esophagus_morphology0.76688078
102MP0001145_abnormal_male_reproductive0.76631525
103MP0004185_abnormal_adipocyte_glucose0.76629848
104MP0003119_abnormal_digestive_system0.76381125
105MP0000428_abnormal_craniofacial_morphol0.76222851
106MP0002098_abnormal_vibrissa_morphology0.75579161
107MP0002009_preneoplasia0.75497047
108MP0002938_white_spotting0.75035717
109MP0001346_abnormal_lacrimal_gland0.74952322
110MP0003121_genomic_imprinting0.74890184
111MP0000627_abnormal_mammary_gland0.74739848
112MP0002429_abnormal_blood_cell0.74446013
113MP0005621_abnormal_cell_physiology0.74283346
114MP0002877_abnormal_melanocyte_morpholog0.74187756
115MP0010678_abnormal_skin_adnexa0.72608501
116MP0004947_skin_inflammation0.72513277
117MP0002166_altered_tumor_susceptibility0.72417126
118MP0009840_abnormal_foam_cell0.72331609
119MP0000733_abnormal_muscle_development0.71873823
120MP0000377_abnormal_hair_follicle0.71360697
121MP0003115_abnormal_respiratory_system0.71009333
122MP0005384_cellular_phenotype0.70868239
123MP0005670_abnormal_white_adipose0.70028706
124MP0004133_heterotaxia0.69930737
125MP0002006_tumorigenesis0.68562938
126MP0006036_abnormal_mitochondrial_physio0.68214752
127MP0009697_abnormal_copulation0.67675083
128MP0002269_muscular_atrophy0.67575466
129MP0000750_abnormal_muscle_regeneration0.67367626
130MP0003436_decreased_susceptibility_to0.66406947
131MP0000716_abnormal_immune_system0.64816790
132MP0001915_intracranial_hemorrhage0.64731997
133MP0000358_abnormal_cell_content/0.64309591
134MP0002092_abnormal_eye_morphology0.64142549
135MP0000653_abnormal_sex_gland0.61712331
136MP0001119_abnormal_female_reproductive0.61517562
137MP0002653_abnormal_ependyma_morphology0.61448305
138MP0001835_abnormal_antigen_presentation0.61275897
139MP0002405_respiratory_system_inflammati0.60238744
140MP0003937_abnormal_limbs/digits/tail_de0.59845628

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)3.80088415
2Breast hypoplasia (HP:0003187)3.60461053
3Ependymoma (HP:0002888)3.57169584
4Selective tooth agenesis (HP:0001592)3.47655049
5Birth length less than 3rd percentile (HP:0003561)3.36577926
6Chromsome breakage (HP:0040012)3.29986053
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.20813437
8Colon cancer (HP:0003003)3.17137119
9Abnormality of cells of the erythroid lineage (HP:0012130)3.16784745
10Microvesicular hepatic steatosis (HP:0001414)3.05784794
11Thrombocytosis (HP:0001894)2.93483613
12Aplastic anemia (HP:0001915)2.89321672
13Abnormal number of erythroid precursors (HP:0012131)2.84218788
14Flat acetabular roof (HP:0003180)2.83701429
15Trismus (HP:0000211)2.77683173
16Oral leukoplakia (HP:0002745)2.77596548
17Abnormality of glycolysis (HP:0004366)2.77553319
18Abnormal gallbladder physiology (HP:0012438)2.69451216
19Cholecystitis (HP:0001082)2.69451216
20Multiple enchondromatosis (HP:0005701)2.69354030
21Agnosia (HP:0010524)2.61664217
22Protrusio acetabuli (HP:0003179)2.52395790
23Increased serum pyruvate (HP:0003542)2.51454439
24Patellar aplasia (HP:0006443)2.51123499
25Myelodysplasia (HP:0002863)2.49999989
26Hyperacusis (HP:0010780)2.48646112
27Metaphyseal cupping (HP:0003021)2.46896253
28Abnormality of the preputium (HP:0100587)2.46648537
29Ragged-red muscle fibers (HP:0003200)2.43541877
30Meckel diverticulum (HP:0002245)2.42158151
31Rough bone trabeculation (HP:0100670)2.41892975
32Medulloblastoma (HP:0002885)2.41164443
33Progressive external ophthalmoplegia (HP:0000590)2.40302378
34Neoplasm of the pancreas (HP:0002894)2.40163797
35Aplasia/Hypoplasia of the patella (HP:0006498)2.39611316
36Pallor (HP:0000980)2.37682166
37Carpal bone hypoplasia (HP:0001498)2.36716643
3811 pairs of ribs (HP:0000878)2.36036059
39Absent thumb (HP:0009777)2.35121788
40Impulsivity (HP:0100710)2.34479832
41High anterior hairline (HP:0009890)2.33374041
42Abnormality of chromosome stability (HP:0003220)2.32144593
43Abnormality of the ileum (HP:0001549)2.31800052
44Premature ovarian failure (HP:0008209)2.31412103
45Absent epiphyses (HP:0010577)2.31375171
46Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.31375171
47Breech presentation (HP:0001623)2.28422261
48Rhabdomyolysis (HP:0003201)2.23227870
49Centrally nucleated skeletal muscle fibers (HP:0003687)2.22631930
50Myopathic facies (HP:0002058)2.22507056
51Increased connective tissue (HP:0009025)2.22139767
52Broad distal phalanx of finger (HP:0009836)2.21294176
53Abnormality of the calcaneus (HP:0008364)2.21096245
54Deviation of the thumb (HP:0009603)2.19677486
55Absent radius (HP:0003974)2.19375237
56Cervical subluxation (HP:0003308)2.18750739
57Abnormality of the astrocytes (HP:0100707)2.17586942
58Astrocytoma (HP:0009592)2.17586942
59Missing ribs (HP:0000921)2.16471622
60Biliary tract neoplasm (HP:0100574)2.16069823
61Abnormality of the thoracic spine (HP:0100711)2.15995447
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.14654023
63Vertebral compression fractures (HP:0002953)2.14635339
64Reticulocytosis (HP:0001923)2.12744932
65Macrocytic anemia (HP:0001972)2.12435434
66Rhabdomyosarcoma (HP:0002859)2.12095114
67Proximal placement of thumb (HP:0009623)2.11543444
68Disproportionate tall stature (HP:0001519)2.10722087
69Hypoplasia of the capital femoral epiphysis (HP:0003090)2.07924285
70Premature skin wrinkling (HP:0100678)2.07812635
71Small intestinal stenosis (HP:0012848)2.07351105
72Duodenal stenosis (HP:0100867)2.07351105
73Flattened epiphyses (HP:0003071)2.05782443
74Abnormality of the anterior horn cell (HP:0006802)2.05672247
75Degeneration of anterior horn cells (HP:0002398)2.05672247
76Basal cell carcinoma (HP:0002671)2.03953920
77Progressive muscle weakness (HP:0003323)2.02677172
78Premature rupture of membranes (HP:0001788)2.02528560
79Bone marrow hypocellularity (HP:0005528)2.01711899
80Thoracic kyphosis (HP:0002942)1.99872624
81Aplasia involving forearm bones (HP:0009822)1.98834049
82Absent forearm bone (HP:0003953)1.98834049
83Ureteral duplication (HP:0000073)1.98447071
84Biconcave vertebral bodies (HP:0004586)1.97910589
85Exercise-induced myalgia (HP:0003738)1.94359630
86Glioma (HP:0009733)1.92110528
87Amaurosis fugax (HP:0100576)1.91659861
88Pustule (HP:0200039)1.90228300
89Tracheoesophageal fistula (HP:0002575)1.89901792
90Broad palm (HP:0001169)1.89353112
91Right ventricular cardiomyopathy (HP:0011663)1.89124965
92Duplicated collecting system (HP:0000081)1.88986889
93Abnormal tarsal ossification (HP:0008369)1.88525690
94Ectopic kidney (HP:0000086)1.88275105
95Aplasia/hypoplasia of the humerus (HP:0006507)1.88169508
96Delayed epiphyseal ossification (HP:0002663)1.85756047
97Thin ribs (HP:0000883)1.85233580
98Flared metaphyses (HP:0003015)1.84693216
99Colitis (HP:0002583)1.83842048
100Squamous cell carcinoma (HP:0002860)1.82225768
101Deep palmar crease (HP:0006191)1.81636714
102Abnormality of the acetabulum (HP:0003170)1.80978526
103Pili torti (HP:0003777)1.80785407
104Microretrognathia (HP:0000308)1.80487109
105Shawl scrotum (HP:0000049)1.80468263
106Blepharitis (HP:0000498)1.79603324
107Atresia of the external auditory canal (HP:0000413)1.79371638
108Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78950637
109Neoplasm of the colon (HP:0100273)1.76438889
110Duplication of thumb phalanx (HP:0009942)1.76087583
111Abnormal trabecular bone morphology (HP:0100671)1.74236961
112Microglossia (HP:0000171)1.73261230
113Long palpebral fissure (HP:0000637)1.72479779
114Partial duplication of thumb phalanx (HP:0009944)1.72231805
115Abnormality of carpal bone ossification (HP:0006257)1.72182966
116Spastic diplegia (HP:0001264)1.72052654
117Premature graying of hair (HP:0002216)1.71934741
118Malignant gastrointestinal tract tumors (HP:0006749)1.71722204
119Gastrointestinal carcinoma (HP:0002672)1.71722204
120High pitched voice (HP:0001620)1.71485904
121Short humerus (HP:0005792)1.71006205
122Ankyloglossia (HP:0010296)1.70049889
123Abnormality of the renal collecting system (HP:0004742)1.69930723
124Seborrheic dermatitis (HP:0001051)1.69373402
125Abnormality of reticulocytes (HP:0004312)1.68951888
126Abnormality of the duodenum (HP:0002246)1.68933455
127Abnormal number of incisors (HP:0011064)1.68869704
128Abnormal biliary tract morphology (HP:0012440)1.68758197
129Increased nuchal translucency (HP:0010880)1.68719541
130Abnormal lung lobation (HP:0002101)1.68580387
131Overlapping toe (HP:0001845)1.66980725
132Rectal prolapse (HP:0002035)1.66796189
133Abnormality of the distal phalanx of the thumb (HP:0009617)1.65809807
134* Sloping forehead (HP:0000340)1.65311235
135Advanced eruption of teeth (HP:0006288)1.64734022
136IgM deficiency (HP:0002850)1.64090163
137Cellular immunodeficiency (HP:0005374)1.63879144
138Ulnar deviation of the wrist (HP:0003049)1.63836565
139Neoplasm of striated muscle (HP:0009728)1.63680253
140Small epiphyses (HP:0010585)1.63234426
141Facial cleft (HP:0002006)1.63036065
142Preauricular skin tag (HP:0000384)1.62261555
143Cafe-au-lait spot (HP:0000957)1.61750606
144Calcaneovalgus deformity (HP:0001848)1.61609503
145Asymmetry of the thorax (HP:0001555)1.61516983
146Irregular epiphyses (HP:0010582)1.60845701
147Glossoptosis (HP:0000162)1.60832348
148Abnormal foot bone ossification (HP:0010675)1.59454374
149Prominent nose (HP:0000448)1.59345467
150Short thumb (HP:0009778)1.59088369
151Gout (HP:0001997)1.58465002
152Abnormality of the carotid arteries (HP:0005344)1.58352852
153Horseshoe kidney (HP:0000085)1.58014090
154Lymphoma (HP:0002665)1.57842742
155Secondary amenorrhea (HP:0000869)1.57596796
156Insomnia (HP:0100785)1.57026224
157Hypoplasia of the radius (HP:0002984)1.56442648
158Abnormal ossification of hand bones (HP:0005921)1.56003338
159Abnormality of small intestinal villus morphology (HP:0011472)1.55591111
160Villous atrophy (HP:0011473)1.55591111
161Abnormality of the fingertips (HP:0001211)1.55330295
162Delayed cranial suture closure (HP:0000270)1.55314183
163Myoglobinuria (HP:0002913)1.55109758
164Skin tags (HP:0010609)1.53292699
165Rhizomelia (HP:0008905)1.52832436
166Abnormality of the umbilical cord (HP:0010881)1.52170581
167Ulnar bowing (HP:0003031)1.51891332
168Renal duplication (HP:0000075)1.51107361
169Abnormality of oral frenula (HP:0000190)1.50281224
170Cholelithiasis (HP:0001081)1.47962308
171Thin bony cortex (HP:0002753)1.46454796
172Midface retrusion (HP:0011800)1.46107772
173Diastasis recti (HP:0001540)1.45830195
174Blue sclerae (HP:0000592)1.45230690
175Wide cranial sutures (HP:0010537)1.44468905
176Back pain (HP:0003418)1.44363715
177Cupped ribs (HP:0000887)1.43785657
178Natal tooth (HP:0000695)1.43567314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.14740385
2EEF2K3.65263558
3WEE13.12962455
4BUB13.07039026
5EPHA22.75548168
6NEK22.74080631
7CDC72.72239721
8CDK122.59519778
9TTK2.42085306
10RPS6KB22.40349144
11VRK22.37355625
12ICK2.19180216
13STK102.10360802
14TSSK62.09647174
15NEK11.94391974
16PKN21.90846451
17PRPF4B1.87140979
18PASK1.83793163
19NME21.82493101
20PBK1.73541363
21EIF2AK11.72914006
22BRSK21.68354604
23FGFR41.63294276
24CDK71.62253102
25TAF11.59645026
26FLT31.58647303
27PLK11.58220716
28PLK41.57140554
29TRIB31.55781322
30MAP3K81.53760532
31AURKB1.52728319
32TAOK21.48887379
33ATR1.45957028
34LATS11.38958037
35CDK191.36566950
36IRAK31.35479754
37MAP4K11.35374057
38CDK41.34335825
39SRPK11.33481418
40RPS6KA41.33146785
41LRRK21.32294753
42ERN11.31979849
43MAPKAPK31.28173488
44SIK11.20023944
45EIF2AK31.19191713
46DYRK31.17711871
47PAK41.16672285
48STK31.12794484
49STK41.12672711
50MAP2K31.12514428
51MST41.11510125
52AKT31.11469750
53BRD41.07459106
54CHEK21.07451020
55MKNK11.07437429
56ZAK1.06996509
57NME11.06535330
58MAP3K101.05025661
59CHEK11.04298852
60TGFBR11.02660982
61TTN1.01267076
62MST1R1.01074864
63TESK20.99126893
64PIM10.93577003
65CDK80.90053101
66STK160.88816943
67ZAP700.87673521
68AURKA0.87394593
69CDK60.87355272
70PLK30.87117971
71PDGFRA0.86828794
72BRAF0.82347909
73JAK30.81570671
74STK38L0.80999719
75MAP3K30.80861504
76PTK60.77866574
77MTOR0.77316926
78RIPK10.76069785
79BCKDK0.75391750
80ACVR1B0.75370855
81BTK0.75275506
82TLK10.73794413
83ALK0.73627544
84CDK90.71242660
85CDK20.69314449
86CSF1R0.69155771
87ATM0.67858201
88TRPM70.67463294
89BLK0.65224917
90KSR20.65096910
91PDK20.64662268
92TYK20.63990749
93PRKCI0.62988012
94GRK60.62486223
95MAP2K20.60362889
96SCYL20.59145331
97VRK10.58848126
98PAK10.56412459
99MELK0.55614576
100BRSK10.54682154
101LMTK20.53730285
102CSNK2A20.53261400
103PDK40.52922516
104PDK30.52922516
105MAPK110.52709033
106CLK10.51785894
107PAK20.51613166
108MAPKAPK50.50989592
109KDR0.50193894
110CHUK0.47965815
111BMX0.47240800
112MKNK20.45606958
113AKT20.45303204
114CDK10.44038208
115MET0.43957750
116DYRK1B0.43768337
117MARK20.41705835
118EIF2AK20.41304119
119CSNK2A10.41101615
120RPS6KC10.39394867
121RPS6KL10.39394867
122DDR20.39215917
123MAPKAPK20.38140370
124IKBKB0.38105228
125LATS20.37793495
126MAP3K70.37539338
127ARAF0.36836627
128NEK90.36519191
129FGFR30.36033366
130TIE10.35740513
131RPS6KA60.35275381
132MAP2K60.35246212
133TESK10.35045426
134MAP3K110.35022591
135ILK0.32829826
136RPS6KA10.31904066

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.01432176
2Mismatch repair_Homo sapiens_hsa034303.61751935
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.15521806
4Ribosome_Homo sapiens_hsa030103.10532718
5RNA transport_Homo sapiens_hsa030132.94464019
6One carbon pool by folate_Homo sapiens_hsa006702.82075226
7Base excision repair_Homo sapiens_hsa034102.79602607
8Spliceosome_Homo sapiens_hsa030402.79293374
9* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.69021671
10Homologous recombination_Homo sapiens_hsa034402.52372245
11RNA polymerase_Homo sapiens_hsa030202.51557879
12Cell cycle_Homo sapiens_hsa041102.39893103
13Nucleotide excision repair_Homo sapiens_hsa034202.33421597
14Proteasome_Homo sapiens_hsa030502.24063992
15Pyrimidine metabolism_Homo sapiens_hsa002401.91574854
16Fanconi anemia pathway_Homo sapiens_hsa034601.86786258
17Non-homologous end-joining_Homo sapiens_hsa034501.84821797
18p53 signaling pathway_Homo sapiens_hsa041151.63354380
19mRNA surveillance pathway_Homo sapiens_hsa030151.56829460
20RNA degradation_Homo sapiens_hsa030181.52016871
21Basal transcription factors_Homo sapiens_hsa030221.51141966
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50691975
23Pyruvate metabolism_Homo sapiens_hsa006201.34929260
24Epstein-Barr virus infection_Homo sapiens_hsa051691.18038584
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17975920
26Pentose phosphate pathway_Homo sapiens_hsa000301.16946278
27Arginine biosynthesis_Homo sapiens_hsa002201.15901974
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15299942
29Antigen processing and presentation_Homo sapiens_hsa046121.14206007
30Herpes simplex infection_Homo sapiens_hsa051681.13325755
31Selenocompound metabolism_Homo sapiens_hsa004501.10399745
32Viral carcinogenesis_Homo sapiens_hsa052031.07434607
33Small cell lung cancer_Homo sapiens_hsa052221.04374509
34Cyanoamino acid metabolism_Homo sapiens_hsa004600.95606872
35Biosynthesis of amino acids_Homo sapiens_hsa012300.95505855
36Vitamin B6 metabolism_Homo sapiens_hsa007500.93046005
37Systemic lupus erythematosus_Homo sapiens_hsa053220.90822979
38Legionellosis_Homo sapiens_hsa051340.90316096
39Fatty acid elongation_Homo sapiens_hsa000620.87061561
40Purine metabolism_Homo sapiens_hsa002300.86756242
41HTLV-I infection_Homo sapiens_hsa051660.83925421
42Fructose and mannose metabolism_Homo sapiens_hsa000510.83819806
43MicroRNAs in cancer_Homo sapiens_hsa052060.81988987
44Non-small cell lung cancer_Homo sapiens_hsa052230.80191870
45Arginine and proline metabolism_Homo sapiens_hsa003300.79471848
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79360373
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76959363
48Thyroid cancer_Homo sapiens_hsa052160.76745118
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.73471270
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.73362204
51Glycosaminoglycan degradation_Homo sapiens_hsa005310.73273422
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73217040
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.71493947
54Primary immunodeficiency_Homo sapiens_hsa053400.71331114
55Folate biosynthesis_Homo sapiens_hsa007900.70954274
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70552817
57Galactose metabolism_Homo sapiens_hsa000520.70108324
58Fat digestion and absorption_Homo sapiens_hsa049750.69995759
59Measles_Homo sapiens_hsa051620.69060424
60Sulfur relay system_Homo sapiens_hsa041220.67536463
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67097742
62Chronic myeloid leukemia_Homo sapiens_hsa052200.66520184
63Carbon metabolism_Homo sapiens_hsa012000.66418270
64Fatty acid metabolism_Homo sapiens_hsa012120.66271176
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66034388
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65366225
67Apoptosis_Homo sapiens_hsa042100.64622527
68Influenza A_Homo sapiens_hsa051640.64279115
69Adherens junction_Homo sapiens_hsa045200.61864414
70Endometrial cancer_Homo sapiens_hsa052130.61027146
71Glutathione metabolism_Homo sapiens_hsa004800.60693640
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59542404
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57738740
74Acute myeloid leukemia_Homo sapiens_hsa052210.57428033
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57296414
76Hippo signaling pathway_Homo sapiens_hsa043900.57141358
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56341492
78Bladder cancer_Homo sapiens_hsa052190.56050370
79Fatty acid degradation_Homo sapiens_hsa000710.55690750
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54308899
81Notch signaling pathway_Homo sapiens_hsa043300.53060303
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.52238523
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52053855
84Other glycan degradation_Homo sapiens_hsa005110.51830346
85Insulin signaling pathway_Homo sapiens_hsa049100.50767828
86Hepatitis B_Homo sapiens_hsa051610.49245805
87HIF-1 signaling pathway_Homo sapiens_hsa040660.48872115
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48489714
89Basal cell carcinoma_Homo sapiens_hsa052170.47931263
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47611721
91TGF-beta signaling pathway_Homo sapiens_hsa043500.46650006
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.46413641
93VEGF signaling pathway_Homo sapiens_hsa043700.46351586
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46175204
95N-Glycan biosynthesis_Homo sapiens_hsa005100.45163341
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44649443
97Shigellosis_Homo sapiens_hsa051310.44596641
98Renin-angiotensin system_Homo sapiens_hsa046140.43039508
99Steroid biosynthesis_Homo sapiens_hsa001000.41663385
100Toxoplasmosis_Homo sapiens_hsa051450.41499491
101Leishmaniasis_Homo sapiens_hsa051400.41385518
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40152269
103mTOR signaling pathway_Homo sapiens_hsa041500.39414693
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39230891
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38964677
106Lysine degradation_Homo sapiens_hsa003100.38614728
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38223282
108Phenylalanine metabolism_Homo sapiens_hsa003600.38105510
109AMPK signaling pathway_Homo sapiens_hsa041520.36431564
110Tyrosine metabolism_Homo sapiens_hsa003500.36027705
111Prostate cancer_Homo sapiens_hsa052150.35722369
112Hepatitis C_Homo sapiens_hsa051600.35263885
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34923688
114Arachidonic acid metabolism_Homo sapiens_hsa005900.34802794
115Colorectal cancer_Homo sapiens_hsa052100.34443212
116Pathways in cancer_Homo sapiens_hsa052000.33977342
117Tight junction_Homo sapiens_hsa045300.33737452
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33527923
119Propanoate metabolism_Homo sapiens_hsa006400.33303058
120Oocyte meiosis_Homo sapiens_hsa041140.32876876
121Protein export_Homo sapiens_hsa030600.32461940
122* Metabolic pathways_Homo sapiens_hsa011000.31057401
123Pancreatic cancer_Homo sapiens_hsa052120.30927131
124Inositol phosphate metabolism_Homo sapiens_hsa005620.29266650
125Proteoglycans in cancer_Homo sapiens_hsa052050.29153816
126Vitamin digestion and absorption_Homo sapiens_hsa049770.28145815
127Viral myocarditis_Homo sapiens_hsa054160.27524554
128Hematopoietic cell lineage_Homo sapiens_hsa046400.27124233
129Glucagon signaling pathway_Homo sapiens_hsa049220.25930384
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25562506

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