PYY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)9.57485936
2Golgi transport vesicle coating (GO:0048200)9.57485936
3angiotensin maturation (GO:0002003)8.77201199
4regulation of guanylate cyclase activity (GO:0031282)8.42931266
5positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003577.56985022
6regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.94666391
7positive regulation of guanylate cyclase activity (GO:0031284)6.64421020
8endocrine pancreas development (GO:0031018)6.39117080
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.30566748
10peptide hormone processing (GO:0016486)6.28927192
11positive regulation of insulin secretion (GO:0032024)6.26720349
12COPII vesicle coating (GO:0048208)6.00619569
13NADH metabolic process (GO:0006734)5.92913578
14intestinal absorption (GO:0050892)5.89631668
15retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.87396942
16glandular epithelial cell differentiation (GO:0002067)5.77957943
17calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.75735099
18negative regulation of execution phase of apoptosis (GO:1900118)5.70267151
19protein retention in ER lumen (GO:0006621)5.69790467
20L-alpha-amino acid transmembrane transport (GO:1902475)5.56302612
21positive regulation of pseudopodium assembly (GO:0031274)5.33078167
22positive regulation of vesicle fusion (GO:0031340)5.31148156
23epoxygenase P450 pathway (GO:0019373)5.22216550
24fat-soluble vitamin biosynthetic process (GO:0042362)5.19107252
25positive regulation of peptide hormone secretion (GO:0090277)5.11755184
26regulation of cGMP biosynthetic process (GO:0030826)5.11163163
27positive regulation of amino acid transport (GO:0051957)5.08924817
28positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.06858302
29diacylglycerol metabolic process (GO:0046339)5.06494920
30positive regulation of respiratory burst (GO:0060267)5.02868358
31regulation of cellular extravasation (GO:0002691)4.93495560
32positive regulation of peptide secretion (GO:0002793)4.93299729
33signal peptide processing (GO:0006465)4.84798091
34antibacterial humoral response (GO:0019731)4.81671297
35regulation of pseudopodium assembly (GO:0031272)4.77953439
36antimicrobial humoral response (GO:0019730)4.77837366
37fructose metabolic process (GO:0006000)4.73092615
38positive regulation of peptidyl-threonine phosphorylation (GO:0010800)4.61227567
39hormone catabolic process (GO:0042447)4.58828553
40regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)4.58806943
41glandular epithelial cell development (GO:0002068)4.57129741
42regulation of insulin secretion (GO:0050796)4.47974069
43regulation of systemic arterial blood pressure (GO:0003073)4.47946172
44epithelial cell fate commitment (GO:0072148)4.43520386
45glycine transport (GO:0015816)4.42207316
46insulin secretion (GO:0030073)4.41699163
47peptide catabolic process (GO:0043171)4.37883967
48type B pancreatic cell development (GO:0003323)4.36918438
49lipoprotein transport (GO:0042953)4.35820285
50toxin metabolic process (GO:0009404)4.32084767
51drug metabolic process (GO:0017144)4.30947583
52regulation of bile acid biosynthetic process (GO:0070857)4.30032367
53receptor guanylyl cyclase signaling pathway (GO:0007168)4.29223221
54regulation of cGMP metabolic process (GO:0030823)4.23349621
55response to dietary excess (GO:0002021)4.22937339
56negative regulation of JUN kinase activity (GO:0043508)4.21499831
57vesicle coating (GO:0006901)4.19464302
58growth hormone secretion (GO:0030252)4.18839442
59detection of calcium ion (GO:0005513)4.13760294
60sequestering of metal ion (GO:0051238)4.13188183
61regulation of type B pancreatic cell apoptotic process (GO:2000674)4.12633019
62adhesion of symbiont to host cell (GO:0044650)4.10703773
63virion attachment to host cell (GO:0019062)4.10703773
64regulation of peptide hormone secretion (GO:0090276)4.09787913
65positive regulation of glycoprotein biosynthetic process (GO:0010560)4.08473083
66cellular response to vitamin D (GO:0071305)4.06594581
67regulation of peptide secretion (GO:0002791)4.01680751
68vitamin transport (GO:0051180)3.99121051
69renal system process involved in regulation of blood volume (GO:0001977)3.95806843
70glycolipid catabolic process (GO:0019377)3.94395163
71activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.93412260
72glycosphingolipid catabolic process (GO:0046479)3.92155996
73positive regulation of hormone secretion (GO:0046887)3.91584179
74positive regulation of histone H3-K4 methylation (GO:0051571)3.91164402
75phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.88005124
76positive regulation of cGMP biosynthetic process (GO:0030828)3.83642007
77embryonic retina morphogenesis in camera-type eye (GO:0060059)3.82132356
78urea cycle (GO:0000050)3.81841752
79protein autoprocessing (GO:0016540)3.78124392
80positive regulation of calcium ion import (GO:0090280)3.77997742
81transcytosis (GO:0045056)3.76194502
82arginine metabolic process (GO:0006525)3.76078518
83peptide hormone secretion (GO:0030072)3.75968064
84astrocyte differentiation (GO:0048708)3.74642676
85very-low-density lipoprotein particle assembly (GO:0034379)3.73666892
86regulation of calcium ion-dependent exocytosis (GO:0017158)3.71297464
87positive regulation of nuclease activity (GO:0032075)3.70397594
88peptide secretion (GO:0002790)3.66386726
89urea metabolic process (GO:0019627)3.61937195
90positive regulation of glycoprotein metabolic process (GO:1903020)3.61230600
91regulation of respiratory burst (GO:0060263)3.60060361
92eosinophil chemotaxis (GO:0048245)3.59827160
93bile acid and bile salt transport (GO:0015721)3.59001704
94cGMP-mediated signaling (GO:0019934)3.57584822
95regulation of glucocorticoid secretion (GO:2000849)3.57213699
96regulation of hormone secretion (GO:0046883)3.56521345
97vitamin transmembrane transport (GO:0035461)3.55888392
98negative regulation of digestive system process (GO:0060457)3.54976770
99positive regulation of gluconeogenesis (GO:0045722)3.54444984
100glomerular filtration (GO:0003094)3.53560693
101regulation of vitamin metabolic process (GO:0030656)3.53409633
102glucuronate metabolic process (GO:0019585)3.52521245
103uronic acid metabolic process (GO:0006063)3.52521245
104drug catabolic process (GO:0042737)3.51389346
105cellular glucuronidation (GO:0052695)3.50286721
106ER to Golgi vesicle-mediated transport (GO:0006888)3.49597724
107adhesion of symbiont to host (GO:0044406)3.49209782
108glutathione biosynthetic process (GO:0006750)3.48715384
109nucleoside diphosphate biosynthetic process (GO:0009133)3.48376715
110maintenance of gastrointestinal epithelium (GO:0030277)3.48143300
111* digestion (GO:0007586)3.47081010
112cellular response to cadmium ion (GO:0071276)3.46940334
113protein maturation by protein folding (GO:0022417)3.46414756
114intra-Golgi vesicle-mediated transport (GO:0006891)3.46159417
115cobalamin metabolic process (GO:0009235)3.40214363
116neuron fate specification (GO:0048665)3.38850627
117regulation of systemic arterial blood pressure by hormone (GO:0001990)3.37458363
118regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.37458363
119endocrine process (GO:0050886)3.37458363
120protein localization to Golgi apparatus (GO:0034067)3.36977306
121nonribosomal peptide biosynthetic process (GO:0019184)3.36852731
122oligosaccharide biosynthetic process (GO:0009312)3.35895411
123regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.35732785
124cellular response to zinc ion (GO:0071294)3.35174079
125regulation of nuclease activity (GO:0032069)3.35139267
126exogenous drug catabolic process (GO:0042738)3.34517767
127positive regulation of Cdc42 GTPase activity (GO:0043089)3.33927918
128genitalia morphogenesis (GO:0035112)3.32999425
129glycosylceramide metabolic process (GO:0006677)3.31992798
130nitrogen cycle metabolic process (GO:0071941)3.30345526
131columnar/cuboidal epithelial cell development (GO:0002066)3.30131173
132ER overload response (GO:0006983)3.29739377
133regulation of corticosteroid hormone secretion (GO:2000846)3.28155449
134regulation of triglyceride catabolic process (GO:0010896)3.26403286
135glycerol metabolic process (GO:0006071)3.25096622
136cellular response to glucagon stimulus (GO:0071377)3.25083346
137regulation of peptide transport (GO:0090087)3.25011125
138exocrine pancreas development (GO:0031017)3.24207956
139positive regulation of cGMP metabolic process (GO:0030825)3.23758849
140homocysteine metabolic process (GO:0050667)3.22726786
141lipoprotein metabolic process (GO:0042157)3.22123181
142antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.19958402
143eosinophil migration (GO:0072677)3.19065434
144hormone secretion (GO:0046879)3.17614124
145endoplasmic reticulum unfolded protein response (GO:0030968)3.17411583
146oligosaccharide catabolic process (GO:0009313)3.17032386
147vitamin A metabolic process (GO:0006776)3.17002579
148cellular response to topologically incorrect protein (GO:0035967)3.16713397
149cellular response to unfolded protein (GO:0034620)3.16302553
150regulation of secondary heart field cardioblast proliferation (GO:0003266)3.16224176
151regulation of cardioblast proliferation (GO:0003264)3.16224176
152auditory receptor cell differentiation (GO:0042491)3.15217959
153sphingolipid catabolic process (GO:0030149)3.14828163
154ceramide catabolic process (GO:0046514)3.13760649
155renal filtration (GO:0097205)3.12433256
156positive regulation of growth hormone secretion (GO:0060124)3.11863723
157bundle of His cell to Purkinje myocyte communication (GO:0086069)3.11737448
158plasma lipoprotein particle assembly (GO:0034377)3.11629542
159macroautophagy (GO:0016236)3.08442719
160cellular response to hepatocyte growth factor stimulus (GO:0035729)3.06967159
161response to hepatocyte growth factor (GO:0035728)3.06967159
162ethanol oxidation (GO:0006069)3.06825716
163protein-lipid complex assembly (GO:0065005)3.06063210
164pancreas development (GO:0031016)3.05957619
165glutamine family amino acid biosynthetic process (GO:0009084)3.04255987
166nitric oxide mediated signal transduction (GO:0007263)3.03822724
167phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.03495945
168negative regulation of glycoprotein biosynthetic process (GO:0010561)3.02650337
169hormone transport (GO:0009914)3.01132185
170peptide transport (GO:0015833)3.00420980
171L-phenylalanine catabolic process (GO:0006559)3.00393479
172erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.00393479
173GDP-mannose metabolic process (GO:0019673)2.98610918
174sulfate transmembrane transport (GO:1902358)2.98608391
175alkaloid metabolic process (GO:0009820)2.97844174
176iron coordination entity transport (GO:1901678)2.96212156
177ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.96168213
178membrane lipid catabolic process (GO:0046466)2.95935310
179phosphatidylserine acyl-chain remodeling (GO:0036150)2.95781835
180fat-soluble vitamin metabolic process (GO:0006775)2.94544144
181peptide metabolic process (GO:0006518)2.93815925
182purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.93350664
1833-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.93350664
184ER-nucleus signaling pathway (GO:0006984)2.92698647
185protein N-linked glycosylation via asparagine (GO:0018279)2.91697505
186excretion (GO:0007588)2.91636909
187fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.91383727
188peptidyl-asparagine modification (GO:0018196)2.88725549
189signal transduction involved in regulation of gene expression (GO:0023019)2.87721421
190pharyngeal system development (GO:0060037)2.86729929
191Golgi organization (GO:0007030)2.83514816
192pteridine-containing compound biosynthetic process (GO:0042559)2.82779852
193primitive streak formation (GO:0090009)2.82669916
194regulation of beta-amyloid formation (GO:1902003)2.77991343
195response to endoplasmic reticulum stress (GO:0034976)2.76854160

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human5.61007071
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.62924619
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.55317182
4PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.52008018
5HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.28892840
6DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.13170041
7GATA1_22025678_ChIP-Seq_K562_Human2.95700397
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.63559481
9GATA6_25053715_ChIP-Seq_YYC3_Human2.47329558
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.41750915
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.32178961
12SRY_22984422_ChIP-ChIP_TESTIS_Rat2.28932011
13ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.22092897
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.20408480
15STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.16435717
16NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.16045759
17FOXO3_23340844_ChIP-Seq_DLD1_Human2.09506855
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse12.5526803
19PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.99362387
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.94801002
21BP1_19119308_ChIP-ChIP_Hs578T_Human1.93518160
22NR3C1_23031785_ChIP-Seq_PC12_Mouse1.85344112
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.78853206
24BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.78576639
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77764628
26ZNF263_19887448_ChIP-Seq_K562_Human1.74662922
27OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.74317970
28SOX2_27498859_Chip-Seq_STOMACH_Mouse1.73476106
29FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.56918004
30REST_19997604_ChIP-ChIP_NEURONS_Mouse1.55836442
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55396366
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54085451
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53283060
34SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.51169020
35LXR_22292898_ChIP-Seq_THP-1_Human1.50972157
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.47712261
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.45810255
38SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.44748476
39FOXA1_25552417_ChIP-Seq_VCAP_Human1.44695596
40RACK7_27058665_Chip-Seq_MCF-7_Human1.43801304
41SA1_27219007_Chip-Seq_Bcells_Human1.43644476
42SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42890219
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42822292
44BCL6_27268052_Chip-Seq_Bcells_Human1.42572029
45KLF5_25053715_ChIP-Seq_YYC3_Human1.41536747
46BCOR_27268052_Chip-Seq_Bcells_Human1.40747611
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.40015621
48IGF1R_20145208_ChIP-Seq_DFB_Human1.37033654
49FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36435374
50FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.34271148
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33885582
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33691664
53ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33516953
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33366027
55STAT1_20625510_ChIP-Seq_HELA_Human1.33172620
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31858092
57GABP_17652178_ChIP-ChIP_JURKAT_Human1.27079771
58ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26353980
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.26225205
60REST_21632747_ChIP-Seq_MESCs_Mouse1.24603094
61TP53_22573176_ChIP-Seq_HFKS_Human1.24474323
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.23562775
63CTCF_27219007_Chip-Seq_Bcells_Human1.21601349
64* HNF4A_19822575_ChIP-Seq_HepG2_Human1.21556318
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21253544
66NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21128319
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.19738128
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19679613
69NANOG_20526341_ChIP-Seq_ESCs_Human1.19249980
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18958268
71EGR1_19032775_ChIP-ChIP_M12_Human1.18148387
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17838838
73YY1_22570637_ChIP-Seq_MALME-3M_Human1.17809423
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16878168
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16397455
76CDX2_22108803_ChIP-Seq_LS180_Human1.16382579
77OCT4_18692474_ChIP-Seq_MEFs_Mouse1.16306750
78LXR_22158963_ChIP-Seq_LIVER_Mouse1.15601540
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14375940
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.14116905
81TFEB_21752829_ChIP-Seq_HELA_Human1.14032482
82GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.13476807
83SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13349984
84VDR_22108803_ChIP-Seq_LS180_Human1.13209343
85SOX2_21211035_ChIP-Seq_LN229_Human1.12193791
86CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.11399829
87ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11340808
88RUNX1_27514584_Chip-Seq_MCF-7_Human1.11057263
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10702860
90RXR_22158963_ChIP-Seq_LIVER_Mouse1.10455279
91P53_21459846_ChIP-Seq_SAOS-2_Human1.08921765
92LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08431648
93CLOCK_20551151_ChIP-Seq_293T_Human1.07418649
94SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06349604
95ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05420195
96STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05416699
97TP63_17297297_ChIP-ChIP_HaCaT_Human1.04493924
98RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04229117
99* CEBPB_22108803_ChIP-Seq_LS180_Human1.03356106
100SOX2_20726797_ChIP-Seq_SW620_Human1.02951774
101PHF8_20622854_ChIP-Seq_HELA_Human1.02839600
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02658275
103P300_27268052_Chip-Seq_Bcells_Human1.02293316
104PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02139016
105TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01600765
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01131367
107WT1_19549856_ChIP-ChIP_CCG9911_Human1.00943325
108JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.99605184
109STAT3_23295773_ChIP-Seq_U87_Human0.98568694
110POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97752034
111POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96924335
112FOXH1_21741376_ChIP-Seq_ESCs_Human0.96638234
113CTCF_20526341_ChIP-Seq_ESCs_Human0.95968508
114MYC_19829295_ChIP-Seq_ESCs_Human0.95609251
115DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95504540
116ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95049232
117PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94799250
118IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94339397
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93715680
120NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93606593
121FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93414899
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93211183
123CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93112488
124TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92833369
125BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92581671
126* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92093632
127PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91112314
128E2F1_20622854_ChIP-Seq_HELA_Human0.90374983
129ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88167232
130CTCF_26484167_Chip-Seq_Bcells_Mouse0.87092904
131TP63_22573176_ChIP-Seq_HFKS_Human0.86534784
132IRF8_22096565_ChIP-ChIP_GC-B_Human0.86337483
133CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85930950
134PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85309425
135FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.82870997
136FOXA1_21572438_ChIP-Seq_LNCaP_Human0.82782997
137ZFX_18555785_ChIP-Seq_MESCs_Mouse0.82179004
138ETV2_25802403_ChIP-Seq_MESCs_Mouse0.81381340
139SOX2_21211035_ChIP-Seq_LN229_Gbm0.80393454
140* FOXA2_19822575_ChIP-Seq_HepG2_Human0.80224427
141RARB_27405468_Chip-Seq_BRAIN_Mouse0.79537617
142EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.79259470
143GATA4_25053715_ChIP-Seq_YYC3_Human0.76307561
144GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.76194087
145ELK1_22589737_ChIP-Seq_MCF10A_Human0.75769112
146RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.75736158
147AR_20517297_ChIP-Seq_VCAP_Human0.74636244
148ERG_20887958_ChIP-Seq_HPC-7_Mouse0.74563227
149LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.74432437
150MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.73738925
151ELF1_17652178_ChIP-ChIP_JURKAT_Human0.72625361
152GATA3_24758297_ChIP-Seq_MCF-7_Human0.72478843
153ELK1_19687146_ChIP-ChIP_HELA_Human0.72227619
154CHD1_26751641_Chip-Seq_LNCaP_Human0.71695089
155FOXA1_25329375_ChIP-Seq_VCAP_Human0.71246719
156FOXA1_27270436_Chip-Seq_PROSTATE_Human0.71246719
157BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70750785
158* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70383471
159EZH2_27294783_Chip-Seq_ESCs_Mouse0.69598402
160HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.69534855
161CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.69425415
162PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.68277977
163GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.67584458
164PPARA_22158963_ChIP-Seq_LIVER_Mouse0.67518144
165SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.67473003
166NR3C1_21868756_ChIP-Seq_MCF10A_Human0.67089577
167GATA3_27048872_Chip-Seq_THYMUS_Human0.66914012
168E2F1_17053090_ChIP-ChIP_MCF-7_Human0.66233553
169NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.65747847
170PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.65573758
171CREB1_26743006_Chip-Seq_LNCaP_Human0.65499507
172NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.64780399
173ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.64283115
174* GATA1_19941826_ChIP-Seq_K562_Human0.63771649

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism7.06279735
2MP0005360_urolithiasis6.49915906
3MP0009379_abnormal_foot_pigmentation4.82623399
4MP0003195_calcinosis4.78674616
5* MP0000013_abnormal_adipose_tissue4.07082842
6MP0005379_endocrine/exocrine_gland_phen3.98194300
7MP0002909_abnormal_adrenal_gland3.89034981
8MP0010386_abnormal_urinary_bladder3.85063033
9MP0002877_abnormal_melanocyte_morpholog3.62493483
10MP0005085_abnormal_gallbladder_physiolo3.51383716
11MP0001944_abnormal_pancreas_morphology3.48158718
12MP0002693_abnormal_pancreas_physiology3.20374318
13MP0002837_dystrophic_cardiac_calcinosis3.09211164
14MP0004043_abnormal_pH_regulation3.08108466
15MP0005220_abnormal_exocrine_pancreas3.00761480
16MP0009840_abnormal_foam_cell2.95751296
17MP0010155_abnormal_intestine_physiology2.73411609
18MP0003122_maternal_imprinting2.72309370
19MP0000678_abnormal_parathyroid_gland2.70643722
20MP0004147_increased_porphyrin_level2.64974789
21MP0005084_abnormal_gallbladder_morpholo2.38675721
22MP0005409_darkened_coat_color2.34480695
23* MP0000003_abnormal_adipose_tissue2.31821125
24MP0003283_abnormal_digestive_organ2.25222718
25MP0009780_abnormal_chondrocyte_physiolo2.24379123
26MP0002138_abnormal_hepatobiliary_system2.20886486
27MP0004264_abnormal_extraembryonic_tissu2.12217655
28MP0001986_abnormal_taste_sensitivity2.09448741
29MP0003172_abnormal_lysosome_physiology2.08696597
30MP0000490_abnormal_crypts_of2.05684605
31MP0010352_gastrointestinal_tract_polyps2.03162924
32* MP0002078_abnormal_glucose_homeostasis2.01483452
33MP0010329_abnormal_lipoprotein_level2.00550051
34MP0002163_abnormal_gland_morphology1.98652886
35MP0006072_abnormal_retinal_apoptosis1.96069499
36MP0002638_abnormal_pupillary_reflex1.90152379
37MP0008961_abnormal_basal_metabolism1.89857939
38MP0001188_hyperpigmentation1.86798572
39MP0001756_abnormal_urination1.86520421
40MP0004858_abnormal_nervous_system1.84760865
41MP0001873_stomach_inflammation1.83515833
42MP0001765_abnormal_ion_homeostasis1.82382043
43MP0006292_abnormal_olfactory_placode1.79472900
44MP0004270_analgesia1.78201041
45MP0000477_abnormal_intestine_morphology1.73449283
46MP0005365_abnormal_bile_salt1.70272536
47MP0002938_white_spotting1.56984137
48MP0005257_abnormal_intraocular_pressure1.51885664
49MP0001663_abnormal_digestive_system1.51591153
50MP0005166_decreased_susceptibility_to1.50317045
51MP0002928_abnormal_bile_duct1.45409818
52MP0005670_abnormal_white_adipose1.35377705
53MP0002234_abnormal_pharynx_morphology1.34507161
54MP0000613_abnormal_salivary_gland1.34137118
55MP0005381_digestive/alimentary_phenotyp1.29237457
56MP0003806_abnormal_nucleotide_metabolis1.29126714
57MP0003300_gastrointestinal_ulcer1.28747982
58MP0003787_abnormal_imprinting1.28704036
59MP0002136_abnormal_kidney_physiology1.28522220
60MP0005058_abnormal_lysosome_morphology1.28398361
61MP0005636_abnormal_mineral_homeostasis1.27061941
62MP0004782_abnormal_surfactant_physiolog1.22908599
63MP0002796_impaired_skin_barrier1.20317581
64MP0009643_abnormal_urine_homeostasis1.20142449
65* MP0003953_abnormal_hormone_level1.19645053
66MP0002896_abnormal_bone_mineralization1.16547719
67* MP0005645_abnormal_hypothalamus_physiol1.15720085
68MP0003121_genomic_imprinting1.14150535
69MP0003718_maternal_effect1.14079849
70MP0005408_hypopigmentation1.13008550
71MP0001502_abnormal_circadian_rhythm1.12500886
72MP0000631_abnormal_neuroendocrine_gland1.12424550
73MP0003252_abnormal_bile_duct1.10145319
74MP0001501_abnormal_sleep_pattern1.09166648
75MP0003123_paternal_imprinting1.07138171
76MP0000015_abnormal_ear_pigmentation1.06885646
77MP0005174_abnormal_tail_pigmentation1.06708386
78MP0002822_catalepsy1.06603753
79MP0004019_abnormal_vitamin_homeostasis1.05072540
80MP0000538_abnormal_urinary_bladder1.04449777
81MP0002118_abnormal_lipid_homeostasis1.04179509
82* MP0003959_abnormal_lean_body1.03107037
83MP0002751_abnormal_autonomic_nervous1.02908504
84MP0000639_abnormal_adrenal_gland1.02570178
85MP0001764_abnormal_homeostasis1.00577630
86MP0002098_abnormal_vibrissa_morphology0.99390822
87* MP0005375_adipose_tissue_phenotype0.99171242
88MP0002734_abnormal_mechanical_nocicepti0.97382666
89MP0000230_abnormal_systemic_arterial0.96244255
90MP0003868_abnormal_feces_composition0.94345709
91MP0003879_abnormal_hair_cell0.90949831
92MP0005584_abnormal_enzyme/coenzyme_acti0.89357456
93MP0010234_abnormal_vibrissa_follicle0.88070822
94MP0001845_abnormal_inflammatory_respons0.86749988
95MP0005319_abnormal_enzyme/_coenzyme0.85886221
96MP0003119_abnormal_digestive_system0.85868768
97MP0002971_abnormal_brown_adipose0.84200570
98MP0003693_abnormal_embryo_hatching0.84134159
99MP0004145_abnormal_muscle_electrophysio0.82120090
100MP0003045_fibrosis0.81825899
101MP0009333_abnormal_splenocyte_physiolog0.81803044
102MP0003890_abnormal_embryonic-extraembry0.81353008
103MP0001664_abnormal_digestion0.79947258
104MP0005666_abnormal_adipose_tissue0.79357999
105MP0002277_abnormal_respiratory_mucosa0.78859204
106MP0008872_abnormal_physiological_respon0.78053271
107MP0001666_abnormal_nutrient_absorption0.77055367
108MP0005646_abnormal_pituitary_gland0.77034523
109MP0000681_abnormal_thyroid_gland0.76962258
110MP0002733_abnormal_thermal_nociception0.76228705
111MP0001881_abnormal_mammary_gland0.74982809
112MP0009785_altered_susceptibility_to0.74929226
113MP0001270_distended_abdomen0.73815734
114MP0005535_abnormal_body_temperature0.72680424
115MP0003724_increased_susceptibility_to0.72280309
116MP0005448_abnormal_energy_balance0.71811267
117MP0001299_abnormal_eye_distance/0.71285096
118MP0000609_abnormal_liver_physiology0.70199229
119MP0006054_spinal_hemorrhage0.66564721
120MP0002184_abnormal_innervation0.66275598
121MP0005332_abnormal_amino_acid0.66093834
122MP0005451_abnormal_body_composition0.64986485
123MP0002254_reproductive_system_inflammat0.64837526
124MP0008469_abnormal_protein_level0.63849185
125MP0000537_abnormal_urethra_morphology0.62505361
126MP0000427_abnormal_hair_cycle0.62444401
127MP0002168_other_aberrant_phenotype0.61521346
128MP0009115_abnormal_fat_cell0.61454464
129MP0006082_CNS_inflammation0.60376675
130MP0010678_abnormal_skin_adnexa0.60357396
131MP0002876_abnormal_thyroid_physiology0.59834887
132MP0002557_abnormal_social/conspecific_i0.59419314
133MP0005253_abnormal_eye_physiology0.58937049
134MP0002177_abnormal_outer_ear0.58691702
135MP0005025_abnormal_response_to0.58631239
136* MP0005452_abnormal_adipose_tissue0.58565460
137MP0005387_immune_system_phenotype0.58453173
138MP0001790_abnormal_immune_system0.58453173
139MP0000462_abnormal_digestive_system0.58371826
140MP0004233_abnormal_muscle_weight0.57007401
141MP0000465_gastrointestinal_hemorrhage0.56841654
142MP0003633_abnormal_nervous_system0.56272192
143* MP0002069_abnormal_eating/drinking_beha0.55871356
144MP0002090_abnormal_vision0.54278021
145MP0001970_abnormal_pain_threshold0.52011667
146MP0003866_abnormal_defecation0.51552424
147MP0001186_pigmentation_phenotype0.50133398
148MP0002272_abnormal_nervous_system0.48449388
149MP0004947_skin_inflammation0.47249707
150MP0008004_abnormal_stomach_pH0.46402698
151MP0009703_decreased_birth_body0.46264036
152MP0002139_abnormal_hepatobiliary_system0.46234077
153* MP0009642_abnormal_blood_homeostasis0.45632175
154MP0002127_abnormal_cardiovascular_syste0.45352912
155MP0000470_abnormal_stomach_morphology0.44987037
156MP0005501_abnormal_skin_physiology0.44977827
157MP0000955_abnormal_spinal_cord0.43727328
158MP0009672_abnormal_birth_weight0.43605933
159MP0001485_abnormal_pinna_reflex0.43452544

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)8.35367784
2Hyperinsulinemic hypoglycemia (HP:0000825)7.62956221
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.42651391
4Hypoglycemic seizures (HP:0002173)6.96695429
5Malnutrition (HP:0004395)6.90226214
6Hyperglycemia (HP:0003074)6.38444727
7Retinal atrophy (HP:0001105)6.22655412
8Symptomatic seizures (HP:0011145)6.19666637
9Hypoglycemic coma (HP:0001325)6.14063442
10Pancreatic islet-cell hyperplasia (HP:0004510)5.62903178
11Abnormality of calcium-phosphate metabolism (HP:0100530)5.59957883
12Abnormality of proline metabolism (HP:0010907)5.52008409
13Hydroxyprolinuria (HP:0003080)5.52008409
14Abnormality of endocrine pancreas physiology (HP:0012093)5.48316711
15Abnormality of the pancreatic islet cells (HP:0006476)5.48316711
16Abnormality of the vitamin B12 metabolism (HP:0004341)5.10493492
17Ketoacidosis (HP:0001993)5.00620610
18Late onset (HP:0003584)4.97223686
19Large for gestational age (HP:0001520)4.59763178
20Insulin-resistant diabetes mellitus (HP:0000831)4.32686079
21Ileus (HP:0002595)4.30367307
22Hyperuricemia (HP:0002149)4.27592014
23Increased purine levels (HP:0004368)4.27592014
24Confusion (HP:0001289)4.06674222
25Chronic diarrhea (HP:0002028)4.04146442
26Systemic lupus erythematosus (HP:0002725)3.92826153
27Abnormality of aromatic amino acid family metabolism (HP:0004338)3.91487918
28Glycosuria (HP:0003076)3.90123076
29Abnormality of urine glucose concentration (HP:0011016)3.90123076
30Agitation (HP:0000713)3.83099806
31Fat malabsorption (HP:0002630)3.82698039
32Dysostosis multiplex (HP:0000943)3.81346902
33Metabolic alkalosis (HP:0200114)3.55671060
34Abnormality of magnesium homeostasis (HP:0004921)3.54630849
35Hyperparathyroidism (HP:0000843)3.49818231
36Prominent metopic ridge (HP:0005487)3.45368314
37Hypobetalipoproteinemia (HP:0003563)3.37917842
38Decreased circulating renin level (HP:0003351)3.35077980
39Alkalosis (HP:0001948)3.28191696
40Hyperglycinuria (HP:0003108)3.26279357
41Abnormality of purine metabolism (HP:0004352)3.20983029
42Nausea (HP:0002018)3.13631214
43Widely patent fontanelles and sutures (HP:0004492)3.02337129
44Dysautonomia (HP:0002459)3.00025970
45Abnormality of monocarboxylic acid metabolism (HP:0010996)2.99649454
46Renal tubular acidosis (HP:0001947)2.92608363
47Abnormality of glycine metabolism (HP:0010895)2.92283713
48Abnormality of serine family amino acid metabolism (HP:0010894)2.92283713
49Focal segmental glomerulosclerosis (HP:0000097)2.92229957
50Abnormality of the metopic suture (HP:0005556)2.91649867
51Urinary glycosaminoglycan excretion (HP:0003541)2.91285081
52Mucopolysacchariduria (HP:0008155)2.91285081
53Neuroendocrine neoplasm (HP:0100634)2.90196301
54Hypokalemia (HP:0002900)2.89554450
55Menstrual irregularities (HP:0000858)2.87252112
56Insulin resistance (HP:0000855)2.86853890
57Abnormality of nucleobase metabolism (HP:0010932)2.85589314
58Ketosis (HP:0001946)2.81788427
59Nephrolithiasis (HP:0000787)2.81708484
60Osteomalacia (HP:0002749)2.77652705
61Broad face (HP:0000283)2.76877606
62Papilledema (HP:0001085)2.73624355
63EEG with generalized epileptiform discharges (HP:0011198)2.73339596
64Tetany (HP:0001281)2.70559403
65Hypsarrhythmia (HP:0002521)2.70153397
66Steatorrhea (HP:0002570)2.68272085
67Abnormality of small intestinal villus morphology (HP:0011472)2.65886465
68Villous atrophy (HP:0011473)2.65886465
69Hyperkalemia (HP:0002153)2.65508086
70Hyperphosphatemia (HP:0002905)2.64549930
71Abnormal pancreas size (HP:0012094)2.62792010
72Right ventricular cardiomyopathy (HP:0011663)2.62659640
73Abnormality of dicarboxylic acid metabolism (HP:0010995)2.62645816
74Dicarboxylic aciduria (HP:0003215)2.62645816
75Congenital sensorineural hearing impairment (HP:0008527)2.61451153
76Abnormality of polysaccharide metabolism (HP:0011012)2.60946972
77Abnormality of glycosaminoglycan metabolism (HP:0004371)2.60946972
78Abnormality of mucopolysaccharide metabolism (HP:0011020)2.60946972
79Epileptiform EEG discharges (HP:0011182)2.60838931
80Macroorchidism (HP:0000053)2.60491941
81Orthostatic hypotension (HP:0001278)2.60246130
82Pheochromocytoma (HP:0002666)2.57737167
83Megaloblastic anemia (HP:0001889)2.57730449
84Xanthomatosis (HP:0000991)2.53136234
85Abnormality of potassium homeostasis (HP:0011042)2.51518488
86Facial shape deformation (HP:0011334)2.51444843
87Potter facies (HP:0002009)2.51444843
88Abnormality of renin-angiotensin system (HP:0000847)2.50032371
89Flattened epiphyses (HP:0003071)2.48726150
90Progressive neurologic deterioration (HP:0002344)2.46949961
91Methylmalonic aciduria (HP:0012120)2.42208323
92Pili torti (HP:0003777)2.41111737
93Vacuolated lymphocytes (HP:0001922)2.39695992
94Pigmentary retinal degeneration (HP:0001146)2.39423473
95Protuberant abdomen (HP:0001538)2.38538050
96Renal tubular dysfunction (HP:0000124)2.36463092
97Wide cranial sutures (HP:0010537)2.34370804
98Hyperammonemia (HP:0001987)2.32718771
99Hypotension (HP:0002615)2.32674248
100Unilateral renal agenesis (HP:0000122)2.32654232
101Glomerulosclerosis (HP:0000096)2.30514091
102Abnormality of the intrinsic pathway (HP:0010989)2.30151377
103Acanthocytosis (HP:0001927)2.30129526
104Hypomagnesemia (HP:0002917)2.29992681
105Congenital glaucoma (HP:0001087)2.29802301
106Petechiae (HP:0000967)2.28056029
107Vascular calcification (HP:0004934)2.27401497
108Glomerulonephritis (HP:0000099)2.26105979
109Increased CSF protein (HP:0002922)2.24743537
110Hypoplasia of the fovea (HP:0007750)2.23900607
111Aplasia/Hypoplasia of the fovea (HP:0008060)2.23900607
112Restlessness (HP:0000711)2.22518024
113Growth hormone excess (HP:0000845)2.21811257
114Enlarged kidneys (HP:0000105)2.19729340
115Increased circulating renin level (HP:0000848)2.18104329
116Posterior subcapsular cataract (HP:0007787)2.17849122
117Abnormal tarsal ossification (HP:0008369)2.17358518
118Flat acetabular roof (HP:0003180)2.12179705
119Abnormality of chloride homeostasis (HP:0011422)2.10888915
120Hypophosphatemia (HP:0002148)2.09372708
121Abnormality of pyrimidine metabolism (HP:0004353)2.08366662
122Abnormality of the fovea (HP:0000493)2.07270341
123Intestinal atresia (HP:0011100)2.06518734
124Intrahepatic cholestasis (HP:0001406)2.05257099
125Hyperphosphaturia (HP:0003109)2.03956615
126Eczematoid dermatitis (HP:0000976)2.03645834
127Generalized hyperpigmentation (HP:0007440)2.02620185
128Lethargy (HP:0001254)2.02540265
129Hypercortisolism (HP:0001578)2.00809033
130Hypoalbuminemia (HP:0003073)2.00493485
131Abnormal albumin level (HP:0012116)2.00493485
132Gastrointestinal dysmotility (HP:0002579)2.00253165
133Hyperactive renin-angiotensin system (HP:0000841)2.00206087
134Metabolic acidosis (HP:0001942)2.00049734
135Limb hypertonia (HP:0002509)1.98874297
136Abnormal biliary tract morphology (HP:0012440)1.97669467
137Abdominal distention (HP:0003270)1.96124743
138Enlarged epiphyses (HP:0010580)1.95917340
139Hemorrhage of the eye (HP:0011885)1.95390889
140Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.93695570
141Atelectasis (HP:0100750)1.93184858
142Cardiovascular calcification (HP:0011915)1.92124803
143Adrenal overactivity (HP:0002717)1.89558955
144Pancreatitis (HP:0001733)1.89523721
145Hepatoblastoma (HP:0002884)1.88436027
146Axonal loss (HP:0003447)1.82705152
147Tachypnea (HP:0002789)1.82492674
148Chronic bronchitis (HP:0004469)1.82291815
149Nephritis (HP:0000123)1.82291793
150Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82057354
151Gout (HP:0001997)1.81204197
152Abnormal hair laboratory examination (HP:0003328)1.80934087
153Conjugated hyperbilirubinemia (HP:0002908)1.80663431
154Skin nodule (HP:0200036)1.79115753
155Hypothermia (HP:0002045)1.78888002
156Hyperaldosteronism (HP:0000859)1.78308878
157Abnormality of renal excretion (HP:0011036)1.78196964
158Proximal tubulopathy (HP:0000114)1.77998479
159Hypolipoproteinemia (HP:0010981)1.77405685
160Thin bony cortex (HP:0002753)1.74262196
161Ventricular fibrillation (HP:0001663)1.74049791
162Cortical visual impairment (HP:0100704)1.72605232
163Blue irides (HP:0000635)1.71947649
164Flared iliac wings (HP:0002869)1.70617915
165Neoplasm of the heart (HP:0100544)1.69192110
166Hemiparesis (HP:0001269)1.69087499
167Abnormality of vitamin metabolism (HP:0100508)1.68938900
168Testicular neoplasm (HP:0010788)1.65870626
169Bifid tongue (HP:0010297)1.62881329
170Spondylolisthesis (HP:0003302)1.62565561
171Abnormality of liposaccharide metabolism (HP:0010968)1.61576015
172Abnormality of glycosphingolipid metabolism (HP:0004343)1.61576015
173Abnormality of glycolipid metabolism (HP:0010969)1.61576015
174Abnormal urine phosphate concentration (HP:0012599)1.59205688
175Long toe (HP:0010511)1.56713407
176Abnormality of vitamin B metabolism (HP:0004340)1.56628848
177Generalized aminoaciduria (HP:0002909)1.56353006
178Lipid accumulation in hepatocytes (HP:0006561)1.53801344

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK38.55018222
2ACVR1B7.64647977
3MAPK156.02670266
4PIK3CG5.56267705
5STK394.35101296
6INSRR4.22884569
7MST1R3.73484702
8TAOK33.54394203
9FRK3.44246128
10WNK43.26020925
11MAP3K22.70549152
12MST42.55460028
13UHMK12.49647244
14OXSR12.37114773
15PASK2.20063978
16MAP3K122.17478216
17HIPK22.16977943
18EPHB22.01607637
19MAP3K102.00136203
20PRKD31.82028351
21MYLK1.58809757
22MAP2K61.57432971
23ERN11.54802347
24STK241.51984809
25MAP3K11.44033246
26EPHA31.36307845
27CDK191.30230907
28KSR21.28607436
29WNK11.26149952
30DYRK1B1.25957549
31PIK3CA1.25177633
32TLK11.24965043
33TYK21.24135347
34GRK11.23634794
35MAP4K11.23471914
36IRAK31.22626795
37AKT31.16454357
38EPHA21.14258105
39IRAK11.13146377
40PAK31.12885628
41ABL21.10624415
42MATK1.07763451
43LMTK21.07062371
44TESK21.04844412
45CDC42BPA1.02670609
46ARAF1.02046949
47PDK21.00126287
48IKBKE0.99980474
49CAMKK20.94789788
50ERBB20.92302415
51NTRK30.87127493
52BRAF0.86950640
53PTK60.83789631
54PTK20.82766039
55CASK0.82507860
56BMPR1B0.81906313
57SCYL20.80424004
58DMPK0.79528561
59ZAP700.77072797
60NTRK10.75644552
61FER0.75253979
62PDPK10.74311294
63MAP3K130.74275423
64FLT30.73549323
65MAP3K110.73288505
66IRAK40.72042830
67FGFR30.68964345
68MAPK110.65587266
69GRK60.64210778
70DDR20.62295060
71PRKCH0.61514533
72MAP2K20.60922952
73PRKD20.57981584
74RIPK10.57549420
75PRKCI0.55275704
76TBK10.54566954
77PRKCA0.54194150
78STK160.54174165
79BMX0.52928853
80PIM10.52101919
81BRSK20.51168030
82PRKACG0.49550358
83MAP3K90.48638827
84BRD40.48069750
85PAK40.45139849
86CAMK2D0.44732664
87BMPR20.43920638
88MELK0.43364581
89DAPK20.43019552
90IGF1R0.41980824
91PRKCZ0.41852269
92EIF2AK30.41775352
93CSF1R0.41483884
94PDK10.40886522
95MAP2K10.40444996
96MAP3K80.40425203
97ERBB40.40174354
98RPS6KC10.39859145
99RPS6KL10.39859145
100NLK0.39323346
101SGK2230.36379186
102SGK4940.36379186
103ADRBK20.36344643
104SRC0.35980535
105PRKAA20.35614914
106RPS6KA50.35486061
107RPS6KA60.34584862
108PDGFRA0.34377259
109NEK60.34351252
110STK30.34221515
111FGFR40.33131975
112STK38L0.33021170
113EPHA40.32875717
114EPHB10.32481822
115PRKG20.31976893
116LRRK20.31929026
117MTOR0.31850260
118RPS6KA20.31694937
119PRKCQ0.31403180
120NME10.31212456
121RET0.30674769
122CAMK1G0.29278331
123YES10.29248009
124ITK0.28437060
125STK40.28166537
126SGK20.27085523
127DYRK1A0.27084811
128GSK3A0.27015086
129PRKCE0.26747409
130SMG10.26247757
131TAOK10.24975004
132AKT20.24938995
133MAP4K20.24707607
134TESK10.23982228
135RPS6KB10.23677523
136KSR10.23610953
137PRKAA10.23184426
138BRSK10.22630849
139JAK20.21984043
140CSNK1A10.21292836
141MET0.21073618
142PNCK0.20131147
143IRAK20.20075308
144DYRK30.19706078
145CHUK0.19509909
146ERBB30.18795473
147SGK10.16625258
148PRKDC0.16484506
149MARK20.16067925
150DAPK10.15948349
151SGK30.15938888
152ZAK0.14271723
153MAPKAPK30.14103685
154RPS6KA30.13553542
155PRKACA0.12985633
156TRIB30.12764643
157CAMK2B0.12449202
158RPS6KA10.12005116
159CSK0.11983525
160PRKD10.11762341
161MAPKAPK20.11637557
162MAPK100.10815867

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049509.60189322
2Protein export_Homo sapiens_hsa030605.35871976
3Cyanoamino acid metabolism_Homo sapiens_hsa004604.93100909
4Vitamin digestion and absorption_Homo sapiens_hsa049773.99966039
5Insulin secretion_Homo sapiens_hsa049113.57116492
6Mineral absorption_Homo sapiens_hsa049782.94027668
7Arginine biosynthesis_Homo sapiens_hsa002202.89559476
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.79221326
9Type I diabetes mellitus_Homo sapiens_hsa049402.64862705
10Fructose and mannose metabolism_Homo sapiens_hsa000512.20913594
11Sulfur metabolism_Homo sapiens_hsa009202.19970262
12Histidine metabolism_Homo sapiens_hsa003402.17910171
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.15915438
14Glycosaminoglycan degradation_Homo sapiens_hsa005312.12255594
15Type II diabetes mellitus_Homo sapiens_hsa049302.11933228
16Vibrio cholerae infection_Homo sapiens_hsa051102.06416757
17Caffeine metabolism_Homo sapiens_hsa002322.02800561
18Folate biosynthesis_Homo sapiens_hsa007901.92672322
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.80723735
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.77352627
21Chemical carcinogenesis_Homo sapiens_hsa052041.75285064
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.71914938
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70113112
24Other glycan degradation_Homo sapiens_hsa005111.69122576
25N-Glycan biosynthesis_Homo sapiens_hsa005101.69085563
26Retinol metabolism_Homo sapiens_hsa008301.67887627
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.63782103
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.60321240
29Circadian rhythm_Homo sapiens_hsa047101.57141695
30Lysosome_Homo sapiens_hsa041421.51471921
31Cocaine addiction_Homo sapiens_hsa050301.50848479
32Arginine and proline metabolism_Homo sapiens_hsa003301.47147483
33Regulation of autophagy_Homo sapiens_hsa041401.43145696
34Glutathione metabolism_Homo sapiens_hsa004801.40792377
35PPAR signaling pathway_Homo sapiens_hsa033201.36590965
36Glycerolipid metabolism_Homo sapiens_hsa005611.34154008
37Asthma_Homo sapiens_hsa053101.33269823
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.29418602
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24884721
40Amphetamine addiction_Homo sapiens_hsa050311.24494320
41Prion diseases_Homo sapiens_hsa050201.23834194
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.21667518
43Glucagon signaling pathway_Homo sapiens_hsa049221.20004013
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.19802651
45Bile secretion_Homo sapiens_hsa049761.19205929
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17802736
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16176883
48Fatty acid degradation_Homo sapiens_hsa000711.13601200
49Sulfur relay system_Homo sapiens_hsa041221.11107985
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.09347078
51Allograft rejection_Homo sapiens_hsa053301.07498726
52Thyroid hormone synthesis_Homo sapiens_hsa049181.06658068
53ABC transporters_Homo sapiens_hsa020101.04851911
54Pancreatic secretion_Homo sapiens_hsa049721.04577503
55Autoimmune thyroid disease_Homo sapiens_hsa053201.01305079
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97525942
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96783874
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96516649
59Graft-versus-host disease_Homo sapiens_hsa053320.95832657
60Linoleic acid metabolism_Homo sapiens_hsa005910.95755582
61Nitrogen metabolism_Homo sapiens_hsa009100.94773051
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87479694
63GABAergic synapse_Homo sapiens_hsa047270.85819571
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83585520
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83003928
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.82619648
67Circadian entrainment_Homo sapiens_hsa047130.82047297
68Taste transduction_Homo sapiens_hsa047420.80743116
69Dopaminergic synapse_Homo sapiens_hsa047280.79945433
70Synaptic vesicle cycle_Homo sapiens_hsa047210.75553122
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71097104
72Estrogen signaling pathway_Homo sapiens_hsa049150.70630867
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70182521
74Phenylalanine metabolism_Homo sapiens_hsa003600.63964206
75Tight junction_Homo sapiens_hsa045300.63532327
76Selenocompound metabolism_Homo sapiens_hsa004500.61738501
77Renin secretion_Homo sapiens_hsa049240.61207813
78Fatty acid elongation_Homo sapiens_hsa000620.60267507
79Serotonergic synapse_Homo sapiens_hsa047260.59942211
80Insulin resistance_Homo sapiens_hsa049310.59154261
81Cholinergic synapse_Homo sapiens_hsa047250.58098993
82Long-term potentiation_Homo sapiens_hsa047200.57420956
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56092825
84Protein digestion and absorption_Homo sapiens_hsa049740.54436667
85Peroxisome_Homo sapiens_hsa041460.53431459
86Staphylococcus aureus infection_Homo sapiens_hsa051500.53193888
87Long-term depression_Homo sapiens_hsa047300.51891052
88Thyroid cancer_Homo sapiens_hsa052160.51278413
89Hepatitis C_Homo sapiens_hsa051600.50830260
90Gastric acid secretion_Homo sapiens_hsa049710.50257786
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49781495
92Collecting duct acid secretion_Homo sapiens_hsa049660.49770154
93Tyrosine metabolism_Homo sapiens_hsa003500.49699266
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49076094
95Prolactin signaling pathway_Homo sapiens_hsa049170.48962070
96Ether lipid metabolism_Homo sapiens_hsa005650.48860244
97cAMP signaling pathway_Homo sapiens_hsa040240.47282811
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46365202
99Fat digestion and absorption_Homo sapiens_hsa049750.46298952
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.45919796
101Sphingolipid metabolism_Homo sapiens_hsa006000.45008298
102Alcoholism_Homo sapiens_hsa050340.44526316
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42907110
104Insulin signaling pathway_Homo sapiens_hsa049100.41724516
105Dorso-ventral axis formation_Homo sapiens_hsa043200.40180920
106Fatty acid metabolism_Homo sapiens_hsa012120.38207586
107Metabolic pathways_Homo sapiens_hsa011000.37801257
108Renin-angiotensin system_Homo sapiens_hsa046140.36589250
109Morphine addiction_Homo sapiens_hsa050320.34970045
110Pentose phosphate pathway_Homo sapiens_hsa000300.32259602
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32226964
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31231075
113Galactose metabolism_Homo sapiens_hsa000520.30909621
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30149615
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28930239
116Bladder cancer_Homo sapiens_hsa052190.28457911
117Alzheimers disease_Homo sapiens_hsa050100.26877389
118Melanogenesis_Homo sapiens_hsa049160.26542478
119Lysine degradation_Homo sapiens_hsa003100.25795374
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.25601171
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25564760
122Inositol phosphate metabolism_Homo sapiens_hsa005620.25446596
123Oxidative phosphorylation_Homo sapiens_hsa001900.25332119
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25082065
125Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24860004
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24692219
127Ovarian steroidogenesis_Homo sapiens_hsa049130.24651301
128Propanoate metabolism_Homo sapiens_hsa006400.24364694
129Primary bile acid biosynthesis_Homo sapiens_hsa001200.24323498
130Pertussis_Homo sapiens_hsa051330.24022614
131Antigen processing and presentation_Homo sapiens_hsa046120.23867720
132Arachidonic acid metabolism_Homo sapiens_hsa005900.23329687
133Salivary secretion_Homo sapiens_hsa049700.22931540
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22319220
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22264171
136African trypanosomiasis_Homo sapiens_hsa051430.20984993
137Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20056025
138Tryptophan metabolism_Homo sapiens_hsa003800.19914048
139Starch and sucrose metabolism_Homo sapiens_hsa005000.19552125
140Acute myeloid leukemia_Homo sapiens_hsa052210.17904765
141Gap junction_Homo sapiens_hsa045400.17007308
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16616834
143Oxytocin signaling pathway_Homo sapiens_hsa049210.16578741
144GnRH signaling pathway_Homo sapiens_hsa049120.16089248
145Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.15102827
146Wnt signaling pathway_Homo sapiens_hsa043100.15022086
147mTOR signaling pathway_Homo sapiens_hsa041500.13529174
148RNA degradation_Homo sapiens_hsa030180.13049226
149Glycerophospholipid metabolism_Homo sapiens_hsa005640.12605241
150Leishmaniasis_Homo sapiens_hsa051400.12360280
151Parkinsons disease_Homo sapiens_hsa050120.12127184
152Transcriptional misregulation in cancer_Homo sapiens_hsa052020.11901857
153Butanoate metabolism_Homo sapiens_hsa006500.11760501
154Viral myocarditis_Homo sapiens_hsa054160.11280467
155Carbon metabolism_Homo sapiens_hsa012000.09976592
156Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.04061280
157Adipocytokine signaling pathway_Homo sapiens_hsa049200.00384852

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