PYURF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene, which is well-conserved, is encoded by the same bicistronic transcript that encodes phosphatidylinositol glycan anchor biosynthesis, class Y, but the two proteins are unrelated. This gene represents the protein encoded by the upstream open reading frame, while the protein encoded by the downstream open reading frame is represented by GeneID:84992. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.68552380
2ATP synthesis coupled proton transport (GO:0015986)5.33089604
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.33089604
4respiratory electron transport chain (GO:0022904)5.26341290
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.17630094
6electron transport chain (GO:0022900)5.13009532
7oxidative phosphorylation (GO:0006119)4.78922207
8protein deneddylation (GO:0000338)4.74551817
9cullin deneddylation (GO:0010388)4.74424856
10tricarboxylic acid cycle (GO:0006099)4.72707469
11proteasome assembly (GO:0043248)4.70699653
12protein complex biogenesis (GO:0070271)4.36041682
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.33778308
14L-phenylalanine metabolic process (GO:0006558)4.33778308
15branched-chain amino acid catabolic process (GO:0009083)4.30096857
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.23568056
17mitochondrial respiratory chain complex I assembly (GO:0032981)4.23568056
18NADH dehydrogenase complex assembly (GO:0010257)4.23568056
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.15581194
20L-phenylalanine catabolic process (GO:0006559)4.15581194
21respiratory chain complex IV assembly (GO:0008535)4.14056522
22fatty acid beta-oxidation (GO:0006635)4.06254580
23regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.00658552
24deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.99215757
25valine metabolic process (GO:0006573)3.98865913
26mitochondrial respiratory chain complex assembly (GO:0033108)3.93186851
27succinate metabolic process (GO:0006105)3.92799392
28branched-chain amino acid metabolic process (GO:0009081)3.85853207
29aerobic respiration (GO:0009060)3.81518967
30inner mitochondrial membrane organization (GO:0007007)3.80715892
31lysine metabolic process (GO:0006553)3.77684277
32lysine catabolic process (GO:0006554)3.77684277
33NADH metabolic process (GO:0006734)3.75047704
34fatty acid catabolic process (GO:0009062)3.72831800
35quinone biosynthetic process (GO:1901663)3.71222938
36ubiquinone biosynthetic process (GO:0006744)3.71222938
37cytochrome complex assembly (GO:0017004)3.69099836
38regulation of cellular amino acid metabolic process (GO:0006521)3.67884228
39short-chain fatty acid metabolic process (GO:0046459)3.65750427
40platelet dense granule organization (GO:0060155)3.65262807
41ribosomal small subunit assembly (GO:0000028)3.63759716
42RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.62938748
43tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.62938748
44lipid oxidation (GO:0034440)3.62494341
45fatty acid oxidation (GO:0019395)3.62298370
46negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.61647871
47regulation of acyl-CoA biosynthetic process (GO:0050812)3.61621260
48daunorubicin metabolic process (GO:0044597)3.59280311
49polyketide metabolic process (GO:0030638)3.59280311
50doxorubicin metabolic process (GO:0044598)3.59280311
51positive regulation of mitochondrial fission (GO:0090141)3.59081672
52DNA deamination (GO:0045006)3.58210818
53tricarboxylic acid metabolic process (GO:0072350)3.57837420
54protein neddylation (GO:0045116)3.54756403
552-oxoglutarate metabolic process (GO:0006103)3.53251136
56regulation of coenzyme metabolic process (GO:0051196)3.51615765
57regulation of cofactor metabolic process (GO:0051193)3.51615765
58chaperone-mediated protein transport (GO:0072321)3.46176269
59oxaloacetate metabolic process (GO:0006107)3.42393082
60negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.41954595
61positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.41917689
62base-excision repair, AP site formation (GO:0006285)3.41779320
63pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.41208090
64glyoxylate metabolic process (GO:0046487)3.40945745
65cellular ketone body metabolic process (GO:0046950)3.38937543
66monocarboxylic acid catabolic process (GO:0072329)3.38512253
67carnitine metabolic process (GO:0009437)3.35751179
68regulation of mitochondrial translation (GO:0070129)3.34033177
69water-soluble vitamin biosynthetic process (GO:0042364)3.33634293
70protein targeting to mitochondrion (GO:0006626)3.33437678
71heart process (GO:0003015)3.30012993
72heart contraction (GO:0060047)3.30012993
73aromatic amino acid family catabolic process (GO:0009074)3.27926527
74nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.27679432
75regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.27049654
76negative regulation of ligase activity (GO:0051352)3.24196142
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.24196142
78fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.23572016
79DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.20108682
80exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19891368
81aspartate family amino acid catabolic process (GO:0009068)3.17095047
82ATP biosynthetic process (GO:0006754)3.15020767
83amino-acid betaine metabolic process (GO:0006577)3.14086599
84deoxyribose phosphate catabolic process (GO:0046386)3.13588819
85ubiquinone metabolic process (GO:0006743)3.12141528
86* GPI anchor biosynthetic process (GO:0006506)3.11491229
87preassembly of GPI anchor in ER membrane (GO:0016254)3.11365151
88termination of RNA polymerase III transcription (GO:0006386)3.08644608
89transcription elongation from RNA polymerase III promoter (GO:0006385)3.08644608
90protein localization to mitochondrion (GO:0070585)3.08578098
91signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.07384531
92intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.07384531
93low-density lipoprotein particle remodeling (GO:0034374)3.07096011
94establishment of protein localization to mitochondrion (GO:0072655)3.06860852
95cellular respiration (GO:0045333)3.06624803
96signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.06374688
97signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.06374688
98signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.06374688
99pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.06276101
100ketone body metabolic process (GO:1902224)3.04228331
101deoxyribonucleotide catabolic process (GO:0009264)3.02896981
1022-deoxyribonucleotide biosynthetic process (GO:0009265)2.99721920
103deoxyribose phosphate biosynthetic process (GO:0046385)2.99721920
104iron-sulfur cluster assembly (GO:0016226)2.98424698
105metallo-sulfur cluster assembly (GO:0031163)2.98424698
106peptidyl-histidine modification (GO:0018202)2.98418539
107acetyl-CoA metabolic process (GO:0006084)2.96366844
108anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.95432909
109positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.94069737
110purine nucleoside triphosphate biosynthetic process (GO:0009145)2.93871058
111C-terminal protein lipidation (GO:0006501)2.93621302
112Arp2/3 complex-mediated actin nucleation (GO:0034314)2.93171944
113* GPI anchor metabolic process (GO:0006505)2.91285403
114positive regulation of prostaglandin secretion (GO:0032308)2.90643270
115protein-cofactor linkage (GO:0018065)2.90535367
116protein maturation by protein folding (GO:0022417)2.90458339
117signal transduction involved in DNA damage checkpoint (GO:0072422)2.89400058
118signal transduction involved in DNA integrity checkpoint (GO:0072401)2.89400058
119signal transduction involved in cell cycle checkpoint (GO:0072395)2.89383910
120aminoglycoside antibiotic metabolic process (GO:0030647)2.88314163
121purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.88266666
122organic acid catabolic process (GO:0016054)2.88061560
123carboxylic acid catabolic process (GO:0046395)2.88061560
124regulation of relaxation of muscle (GO:1901077)2.87488582
125deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.87321915
126NAD metabolic process (GO:0019674)2.86567853
127regulation of sulfur metabolic process (GO:0042762)2.85875060
128alpha-linolenic acid metabolic process (GO:0036109)2.85681231
129homocysteine metabolic process (GO:0050667)2.84261497
130regulation of oxidative phosphorylation (GO:0002082)2.82764512
131L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.82700442
132coenzyme catabolic process (GO:0009109)2.81991327
133triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.81874877
134pyrimidine nucleotide catabolic process (GO:0006244)2.81521841
135antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.80892651
136ribonucleoprotein complex disassembly (GO:0032988)2.80879583
137deoxyribose phosphate metabolic process (GO:0019692)2.80664630
138sulfur amino acid catabolic process (GO:0000098)2.79214470
139regulation of cilium movement (GO:0003352)2.78938938
140quinone metabolic process (GO:1901661)2.78418540
141positive regulation of ligase activity (GO:0051351)2.77078535
142tryptophan metabolic process (GO:0006568)2.76486966
143regulation of cholesterol esterification (GO:0010872)2.74484041
144hydrogen ion transmembrane transport (GO:1902600)2.74414097
145aldehyde catabolic process (GO:0046185)2.74380557
146establishment of protein localization to mitochondrial membrane (GO:0090151)2.73038907
147indole-containing compound catabolic process (GO:0042436)2.71628227
148indolalkylamine catabolic process (GO:0046218)2.71628227
149tryptophan catabolic process (GO:0006569)2.71628227
150alpha-amino acid catabolic process (GO:1901606)2.71093403
151energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.70963890
152ATP hydrolysis coupled proton transport (GO:0015991)2.70963890
1532-deoxyribonucleotide metabolic process (GO:0009394)2.70301212
154positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.70060928
155regulation of cellular amine metabolic process (GO:0033238)2.69956439
156bile acid biosynthetic process (GO:0006699)2.69757234
157organelle disassembly (GO:1903008)2.69393901
158regulation of triglyceride catabolic process (GO:0010896)2.69335406
159antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.68666815
160DNA damage response, detection of DNA damage (GO:0042769)2.68257007
161polyamine metabolic process (GO:0006595)2.68076905
162nucleotide transmembrane transport (GO:1901679)2.66724212
163ribonucleoside triphosphate biosynthetic process (GO:0009201)2.66336235
164signal peptide processing (GO:0006465)2.66022384
165cellular amino acid catabolic process (GO:0009063)2.65999991
166thioester metabolic process (GO:0035383)2.65458150
167acyl-CoA metabolic process (GO:0006637)2.65458150
168kynurenine metabolic process (GO:0070189)2.64376714
169proton transport (GO:0015992)2.64362622
170regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.62999447
171biotin metabolic process (GO:0006768)2.61641921
172L-methionine salvage (GO:0071267)2.60915730
173L-methionine biosynthetic process (GO:0071265)2.60915730
174amino acid salvage (GO:0043102)2.60915730

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.70636132
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.50836816
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.50232268
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.49912467
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.29715228
6SRF_21415370_ChIP-Seq_HL-1_Mouse3.27023720
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.18119292
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.09190033
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.07822465
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.05280090
11PPARA_22158963_ChIP-Seq_LIVER_Mouse3.04476770
12PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.03438019
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.90356067
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.89647057
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.78296735
16ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.72262473
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54083601
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.44487269
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.42129722
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40088062
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.33870814
22GATA1_22025678_ChIP-Seq_K562_Human2.31280707
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.26234858
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.18605961
25LXR_22158963_ChIP-Seq_LIVER_Mouse2.11279090
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.09717018
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02100451
28MYC_18358816_ChIP-ChIP_MESCs_Mouse2.01217710
29DCP1A_22483619_ChIP-Seq_HELA_Human1.98636568
30CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.98463599
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.96305574
32MYC_18555785_ChIP-Seq_MESCs_Mouse1.92997567
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92290277
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.91534549
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.85882386
36ERG_20887958_ChIP-Seq_HPC-7_Mouse1.81896268
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72913480
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66809076
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.63226757
40ZNF274_21170338_ChIP-Seq_K562_Hela1.63008638
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61527499
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61028389
43VDR_23849224_ChIP-Seq_CD4+_Human1.60957712
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59152402
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.57495398
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52950298
47FOXP3_21729870_ChIP-Seq_TREG_Human1.52722787
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51310295
49BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.49478384
50CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.45519242
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.44661297
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44658601
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40146009
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38298615
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38145109
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36514231
57GABP_19822575_ChIP-Seq_HepG2_Human1.34237138
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.32249338
59IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32025994
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31378521
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27282332
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26092868
63PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.23963027
64TAF15_26573619_Chip-Seq_HEK293_Human1.21022482
65MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16765520
66MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16590942
67IRF1_19129219_ChIP-ChIP_H3396_Human1.14184389
68TP53_22573176_ChIP-Seq_HFKS_Human1.11737477
69TFEB_21752829_ChIP-Seq_HELA_Human1.10902592
70CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.10454148
71FUS_26573619_Chip-Seq_HEK293_Human1.09595750
72GATA4_21415370_ChIP-Seq_HL-1_Mouse1.09590502
73AR_20517297_ChIP-Seq_VCAP_Human1.09273198
74TBX5_21415370_ChIP-Seq_HL-1_Mouse1.09128320
75CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07537792
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07084792
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06920770
78E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06551340
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06037672
80EWS_26573619_Chip-Seq_HEK293_Human1.04410633
81CIITA_25753668_ChIP-Seq_RAJI_Human1.03042468
82XRN2_22483619_ChIP-Seq_HELA_Human1.02244588
83VDR_22108803_ChIP-Seq_LS180_Human1.00792218
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00578112
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00504385
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99821143
87ERG_20517297_ChIP-Seq_VCAP_Human0.98950974
88PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98733865
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98011038
90ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97895296
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96153739
92NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94609467
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94443018
94TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.93799857
95ELK1_19687146_ChIP-ChIP_HELA_Human0.93372849
96PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93364576
97GATA3_26560356_Chip-Seq_TH2_Human0.92961818
98NOTCH1_21737748_ChIP-Seq_TLL_Human0.92959990
99MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92257411
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92111651
101NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91108578
102GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91053354
103MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90273182
104FOXA1_25329375_ChIP-Seq_VCAP_Human0.90259735
105FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90259735
106FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89313008
107SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89281302
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87744716
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86841049
110NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.86699527
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86609084
112SPI1_23547873_ChIP-Seq_NB4_Human0.86531967
113IGF1R_20145208_ChIP-Seq_DFB_Human0.86433309
114AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85288257
115ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85275329
116E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.84626757
117PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84345197
118MYC_19079543_ChIP-ChIP_MESCs_Mouse0.84299130
119GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84069656
120MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83664975
121ELK1_22589737_ChIP-Seq_MCF10A_Human0.82586393
122TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80896248
123PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80620742
124HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.80549349
125SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79961391
126TTF2_22483619_ChIP-Seq_HELA_Human0.79242322
127SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78749056
128NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77251251
129PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.76415614
130SCL_19346495_ChIP-Seq_HPC-7_Human0.75817311
131RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75264924
132HTT_18923047_ChIP-ChIP_STHdh_Human0.74273263
133EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.73851109
134MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.71555365
135MYC_18940864_ChIP-ChIP_HL60_Human0.70210773
136CTCF_26484167_Chip-Seq_Bcells_Mouse0.70178052
137SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69627523
138CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.67254646
139RBPJ_22232070_ChIP-Seq_NCS_Mouse0.67244075
140SOX2_22085726_ChIP-Seq_NPCs_Mouse0.65214250

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.47355316
2MP0005360_urolithiasis3.73365399
3MP0003806_abnormal_nucleotide_metabolis3.65938634
4MP0002837_dystrophic_cardiac_calcinosis3.47517505
5MP0005085_abnormal_gallbladder_physiolo3.32948433
6MP0005365_abnormal_bile_salt3.29177637
7MP0006036_abnormal_mitochondrial_physio3.22815210
8MP0003646_muscle_fatigue3.16158954
9MP0001529_abnormal_vocalization3.05483483
10MP0000749_muscle_degeneration2.86510108
11MP0008875_abnormal_xenobiotic_pharmacok2.75674246
12MP0005332_abnormal_amino_acid2.68893812
13MP0009697_abnormal_copulation2.54788450
14MP0003195_calcinosis2.53591301
15MP0004215_abnormal_myocardial_fiber2.48579842
16MP0006072_abnormal_retinal_apoptosis2.37448476
17MP0004043_abnormal_pH_regulation2.37304921
18MP0002102_abnormal_ear_morphology2.36752361
19MP0009379_abnormal_foot_pigmentation2.29488825
20MP0003186_abnormal_redox_activity2.25845163
21MP0008058_abnormal_DNA_repair2.21245415
22MP0004084_abnormal_cardiac_muscle2.16415913
23MP0003786_premature_aging2.16378908
24MP0004036_abnormal_muscle_relaxation2.06880402
25MP0005319_abnormal_enzyme/_coenzyme2.03181369
26MP0005330_cardiomyopathy1.98328601
27MP0000751_myopathy1.97919722
28MP0001764_abnormal_homeostasis1.94012900
29MP0008789_abnormal_olfactory_epithelium1.93463089
30MP0002638_abnormal_pupillary_reflex1.92451723
31MP0010329_abnormal_lipoprotein_level1.86091687
32MP0005584_abnormal_enzyme/coenzyme_acti1.80451920
33MP0001905_abnormal_dopamine_level1.76809429
34MP0000465_gastrointestinal_hemorrhage1.75295296
35MP0005671_abnormal_response_to1.73420934
36MP0003880_abnormal_central_pattern1.72923500
37MP0002090_abnormal_vision1.71402955
38MP0009785_altered_susceptibility_to1.67588583
39MP0001984_abnormal_olfaction1.67461139
40MP0006035_abnormal_mitochondrial_morpho1.67161872
41MP0002138_abnormal_hepatobiliary_system1.67035574
42MP0004147_increased_porphyrin_level1.66132475
43MP0005083_abnormal_biliary_tract1.65308992
44MP0000372_irregular_coat_pigmentation1.63487447
45MP0002972_abnormal_cardiac_muscle1.62604314
46MP0008775_abnormal_heart_ventricle1.61076324
47MP0005253_abnormal_eye_physiology1.58256809
48MP0004130_abnormal_muscle_cell1.57653664
49MP0009840_abnormal_foam_cell1.55286829
50MP0002095_abnormal_skin_pigmentation1.53503611
51MP0002148_abnormal_hypersensitivity_rea1.52580154
52MP0003252_abnormal_bile_duct1.51346055
53MP0001835_abnormal_antigen_presentation1.48599517
54MP0003011_delayed_dark_adaptation1.46919551
55MP0009046_muscle_twitch1.46449106
56MP0002118_abnormal_lipid_homeostasis1.46061576
57MP0004142_abnormal_muscle_tone1.44689634
58MP0005636_abnormal_mineral_homeostasis1.43544401
59MP0009643_abnormal_urine_homeostasis1.41366565
60MP0005084_abnormal_gallbladder_morpholo1.41361802
61MP0001666_abnormal_nutrient_absorption1.38528420
62MP0005620_abnormal_muscle_contractility1.37121709
63MP0005670_abnormal_white_adipose1.31149837
64MP0002736_abnormal_nociception_after1.28899993
65MP0003137_abnormal_impulse_conducting1.27823659
66MP0001853_heart_inflammation1.26901020
67MP0002078_abnormal_glucose_homeostasis1.26148891
68MP0001542_abnormal_bone_strength1.25819379
69MP0005379_endocrine/exocrine_gland_phen1.23755631
70MP0009384_cardiac_valve_regurgitation1.23150607
71MP0004019_abnormal_vitamin_homeostasis1.23056813
72MP0008877_abnormal_DNA_methylation1.22654243
73MP0002269_muscular_atrophy1.21638280
74MP0000230_abnormal_systemic_arterial1.20451538
75MP0005499_abnormal_olfactory_system1.19689232
76MP0005394_taste/olfaction_phenotype1.19689232
77MP0005385_cardiovascular_system_phenoty1.19414851
78MP0001544_abnormal_cardiovascular_syste1.19414851
79MP0005535_abnormal_body_temperature1.18763891
80MP0005645_abnormal_hypothalamus_physiol1.18196558
81MP0004087_abnormal_muscle_fiber1.17138863
82MP0000609_abnormal_liver_physiology1.15320352
83MP0000358_abnormal_cell_content/1.15020168
84MP0003221_abnormal_cardiomyocyte_apopto1.14755010
85MP0001968_abnormal_touch/_nociception1.10987707
86MP0003656_abnormal_erythrocyte_physiolo1.10262345
87MP0000516_abnormal_urinary_system1.09589425
88MP0005367_renal/urinary_system_phenotyp1.09589425
89MP0005266_abnormal_metabolism1.09519326
90MP0002127_abnormal_cardiovascular_syste1.09224543
91MP0005171_absent_coat_pigmentation1.07771356
92MP0002876_abnormal_thyroid_physiology1.07731949
93MP0003868_abnormal_feces_composition1.06946974
94MP0005551_abnormal_eye_electrophysiolog1.05525466
95MP0002106_abnormal_muscle_physiology1.04626269
96MP0003718_maternal_effect1.04399954
97MP0001501_abnormal_sleep_pattern1.03575553
98MP0005389_reproductive_system_phenotype1.03324370
99MP0002971_abnormal_brown_adipose1.02269566
100MP0005220_abnormal_exocrine_pancreas1.02193073
101MP0000647_abnormal_sebaceous_gland1.01882864
102MP0002272_abnormal_nervous_system1.01454503
103MP0001919_abnormal_reproductive_system1.00998675
104MP0002332_abnormal_exercise_endurance0.99805600
105MP0003724_increased_susceptibility_to0.99023725
106MP0001188_hyperpigmentation0.96024624
107MP0000015_abnormal_ear_pigmentation0.95959754
108MP0000013_abnormal_adipose_tissue0.95934527
109MP0001727_abnormal_embryo_implantation0.95315595
110MP0003191_abnormal_cellular_cholesterol0.94220603
111MP0008469_abnormal_protein_level0.92834173
112MP0004782_abnormal_surfactant_physiolog0.91859768
113MP0004085_abnormal_heartbeat0.91213418
114MP0008872_abnormal_physiological_respon0.88738047
115MP0005376_homeostasis/metabolism_phenot0.88609363
116MP0002160_abnormal_reproductive_system0.88466987
117MP0010094_abnormal_chromosome_stability0.87273596
118MP0009642_abnormal_blood_homeostasis0.86869543
119MP0010386_abnormal_urinary_bladder0.86758032
120MP0002234_abnormal_pharynx_morphology0.84949333
121MP0005058_abnormal_lysosome_morphology0.84537201
122MP0001986_abnormal_taste_sensitivity0.84389738
123MP0010368_abnormal_lymphatic_system0.84157742
124MP0010630_abnormal_cardiac_muscle0.83469919
125MP0004145_abnormal_muscle_electrophysio0.83000810
126MP0006276_abnormal_autonomic_nervous0.82685663
127MP0006082_CNS_inflammation0.82625960
128MP0003279_aneurysm0.82586280
129MP0000747_muscle_weakness0.82447706
130MP0008995_early_reproductive_senescence0.81665537
131MP0005000_abnormal_immune_tolerance0.80445433
132MP0003567_abnormal_fetal_cardiomyocyte0.79558466
133MP0002723_abnormal_immune_serum0.79279056
134MP0003787_abnormal_imprinting0.79226674
135MP0006054_spinal_hemorrhage0.79166131
136MP0000343_altered_response_to0.77420113
137MP0005369_muscle_phenotype0.76614171
138MP0005408_hypopigmentation0.75859128
139MP0000427_abnormal_hair_cycle0.75118656
140MP0004484_altered_response_of0.74448291
141MP0008932_abnormal_embryonic_tissue0.74041473
142MP0001756_abnormal_urination0.73601454
143MP0006138_congestive_heart_failure0.72769141
144MP0001879_abnormal_lymphatic_vessel0.71812405
145MP0005075_abnormal_melanosome_morpholog0.71350809
146MP0000598_abnormal_liver_morphology0.71294781
147MP0005666_abnormal_adipose_tissue0.70970976
148MP0002693_abnormal_pancreas_physiology0.70769707
149MP0009745_abnormal_behavioral_response0.70433157
150MP0000759_abnormal_skeletal_muscle0.69759616
151MP0005167_abnormal_blood-brain_barrier0.69756304
152MP0002452_abnormal_antigen_presenting0.68962092
153MP0005646_abnormal_pituitary_gland0.68209203
154MP0009764_decreased_sensitivity_to0.68174953
155MP0005187_abnormal_penis_morphology0.67949141
156MP0001944_abnormal_pancreas_morphology0.67705581
157MP0001502_abnormal_circadian_rhythm0.66387592
158MP0001800_abnormal_humoral_immune0.66191497
159MP0001845_abnormal_inflammatory_respons0.65382129
160MP0001324_abnormal_eye_pigmentation0.64512505
161MP0003136_yellow_coat_color0.63834746

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)5.32733383
2Hepatocellular necrosis (HP:0001404)4.92986135
3Mitochondrial inheritance (HP:0001427)4.56097615
4Abnormal mitochondria in muscle tissue (HP:0008316)4.55343599
5Acute necrotizing encephalopathy (HP:0006965)4.39735525
6Increased muscle lipid content (HP:0009058)4.35132482
7Increased intramyocellular lipid droplets (HP:0012240)4.31066246
8Hypoglycemic coma (HP:0001325)4.20884534
9Acute encephalopathy (HP:0006846)4.18060991
10Increased CSF lactate (HP:0002490)4.17790287
11Abnormality of aromatic amino acid family metabolism (HP:0004338)4.14020629
12Generalized aminoaciduria (HP:0002909)4.01020392
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.00600236
14Decreased activity of mitochondrial respiratory chain (HP:0008972)4.00600236
15Lipid accumulation in hepatocytes (HP:0006561)3.97416035
16Lactic acidosis (HP:0003128)3.83574460
17Abnormality of dicarboxylic acid metabolism (HP:0010995)3.77452223
18Dicarboxylic aciduria (HP:0003215)3.77452223
19Increased hepatocellular lipid droplets (HP:0006565)3.74515335
20Myoglobinuria (HP:0002913)3.74410513
21Cerebral edema (HP:0002181)3.73726418
22Abnormality of fatty-acid metabolism (HP:0004359)3.73449296
23Ketoacidosis (HP:0001993)3.70398570
24Progressive macrocephaly (HP:0004481)3.63653310
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.48014444
26Ketosis (HP:0001946)3.44739181
27Renal Fanconi syndrome (HP:0001994)3.43678235
28Increased serum lactate (HP:0002151)3.34720064
29Exercise intolerance (HP:0003546)3.31056314
30Hyperammonemia (HP:0001987)3.10145547
31Glycosuria (HP:0003076)3.09693332
32Abnormality of urine glucose concentration (HP:0011016)3.09693332
33Medial flaring of the eyebrow (HP:0010747)3.09657936
34Ragged-red muscle fibers (HP:0003200)3.08712206
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.02104386
36Palpitations (HP:0001962)3.00401847
37Lethargy (HP:0001254)2.99652987
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.98355023
39Abnormality of alanine metabolism (HP:0010916)2.98355023
40Hyperalaninemia (HP:0003348)2.98355023
41Congenital primary aphakia (HP:0007707)2.96963359
42Rhabdomyolysis (HP:0003201)2.93055686
43Respiratory failure (HP:0002878)2.92728934
44Gait imbalance (HP:0002141)2.84979651
45Nephrogenic diabetes insipidus (HP:0009806)2.84361625
46Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.84297589
47Hyperglycinuria (HP:0003108)2.84003809
48Abnormality of glycolysis (HP:0004366)2.82848487
49Increased serum pyruvate (HP:0003542)2.82848487
503-Methylglutaconic aciduria (HP:0003535)2.81908006
51Proximal tubulopathy (HP:0000114)2.81020019
52Exertional dyspnea (HP:0002875)2.80469548
53Renal cortical cysts (HP:0000803)2.80460171
54Exercise-induced myalgia (HP:0003738)2.80335723
55Prolonged partial thromboplastin time (HP:0003645)2.72991855
56Degeneration of anterior horn cells (HP:0002398)2.69105513
57Abnormality of the anterior horn cell (HP:0006802)2.69105513
58Late onset (HP:0003584)2.68049689
59Respiratory difficulties (HP:0002880)2.64080247
60Abnormality of serine family amino acid metabolism (HP:0010894)2.62332293
61Abnormality of glycine metabolism (HP:0010895)2.62332293
62Metabolic acidosis (HP:0001942)2.61127358
63Microvesicular hepatic steatosis (HP:0001414)2.54126097
64Exercise-induced muscle cramps (HP:0003710)2.52880992
65Emotional lability (HP:0000712)2.42845770
66Optic disc pallor (HP:0000543)2.42435689
67CNS demyelination (HP:0007305)2.40889389
68Atrophy/Degeneration involving motor neurons (HP:0007373)2.40659483
69Abnormality of renal resorption (HP:0011038)2.40210290
70Methylmalonic aciduria (HP:0012120)2.39356268
71Retinal dysplasia (HP:0007973)2.38087858
72Hyperglycinemia (HP:0002154)2.37676203
73Hyperphosphaturia (HP:0003109)2.36963238
74Hypothermia (HP:0002045)2.35874500
75Vomiting (HP:0002013)2.31212231
76Short tibia (HP:0005736)2.26852035
77Metaphyseal dysplasia (HP:0100255)2.26127767
78Abnormality of serum amino acid levels (HP:0003112)2.25150505
79Reduced antithrombin III activity (HP:0001976)2.24795007
80Dilated cardiomyopathy (HP:0001644)2.23883202
81Hyperlipoproteinemia (HP:0010980)2.22224006
82Intrahepatic cholestasis (HP:0001406)2.20815956
83Xanthomatosis (HP:0000991)2.19771348
84Nausea (HP:0002018)2.19429794
85Abnormality of the intrinsic pathway (HP:0010989)2.15625454
86Hyperbilirubinemia (HP:0002904)2.13767709
87Calf muscle hypertrophy (HP:0008981)2.13679969
88Delayed CNS myelination (HP:0002188)2.12544486
89Hyperinsulinemic hypoglycemia (HP:0000825)2.07635898
90Neuroendocrine neoplasm (HP:0100634)2.04417900
91Type I transferrin isoform profile (HP:0003642)2.04219604
92Aplasia/hypoplasia of the uterus (HP:0008684)2.03676886
93Sudden death (HP:0001699)2.02981386
94Methylmalonic acidemia (HP:0002912)2.02678027
95Abolished electroretinogram (ERG) (HP:0000550)2.01800339
96Lipoatrophy (HP:0100578)2.00938508
97Hypobetalipoproteinemia (HP:0003563)1.99884542
98Severe combined immunodeficiency (HP:0004430)1.99570907
99Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99194579
100Abnormal urine phosphate concentration (HP:0012599)1.98921446
101Muscle hypertrophy of the lower extremities (HP:0008968)1.98528160
102Hypoglycemic seizures (HP:0002173)1.97019259
103Spastic paraparesis (HP:0002313)1.95478336
104Conjunctival hamartoma (HP:0100780)1.95151059
105Abnormal protein glycosylation (HP:0012346)1.92649786
106Abnormal glycosylation (HP:0012345)1.92649786
107Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92649786
108Abnormal protein N-linked glycosylation (HP:0012347)1.92649786
109IgG deficiency (HP:0004315)1.92131193
110Cerebral hypomyelination (HP:0006808)1.89774715
111Abnormality of aspartate family amino acid metabolism (HP:0010899)1.89535672
112Central scotoma (HP:0000603)1.89483043
113Renal tubular dysfunction (HP:0000124)1.89453873
114Opisthotonus (HP:0002179)1.88974283
115Progressive microcephaly (HP:0000253)1.88857617
116Leukodystrophy (HP:0002415)1.87903883
117Molar tooth sign on MRI (HP:0002419)1.87603006
118Abnormality of midbrain morphology (HP:0002418)1.87603006
119Aplasia/Hypoplasia of the tibia (HP:0005772)1.87361632
120Brushfield spots (HP:0001088)1.86544590
121Hypoplasia of the uterus (HP:0000013)1.85870270
122Muscle stiffness (HP:0003552)1.84655024
123Type 2 muscle fiber atrophy (HP:0003554)1.84293094
124Abnormality of monocarboxylic acid metabolism (HP:0010996)1.81544607
125True hermaphroditism (HP:0010459)1.79010522
126Abnormality of the prostate (HP:0008775)1.75355188
127Genital tract atresia (HP:0001827)1.75078272
128Amyotrophic lateral sclerosis (HP:0007354)1.74655518
129Abnormality of the vitamin B12 metabolism (HP:0004341)1.73099928
130Vaginal atresia (HP:0000148)1.71699743
131Vacuolated lymphocytes (HP:0001922)1.71505022
132X-linked dominant inheritance (HP:0001423)1.69486691
133Delusions (HP:0000746)1.68895824
134Polyphagia (HP:0002591)1.68349338
135CNS hypomyelination (HP:0003429)1.67832905
136Broad foot (HP:0001769)1.67105173
137Abnormality of vitamin B metabolism (HP:0004340)1.66840510
138Blindness (HP:0000618)1.65299262

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.29662219
2MUSK3.80866425
3FLT33.07306580
4PBK3.03909641
5OBSCN3.03722260
6MAP4K22.98436563
7TESK22.90588315
8MYLK2.78024645
9INSRR2.77172871
10ERBB32.68950907
11STK162.47960253
12TESK12.43773477
13PHKG12.40568025
14PHKG22.40568025
15CSNK1G32.39835103
16LMTK22.39318492
17NME22.35949008
18TRIM282.22555797
19PIK3CG2.20877917
20BCR2.19302079
21CSNK1G22.08104056
22NME12.00612578
23TNIK1.97511239
24CSNK1A1L1.92379737
25CSNK1G11.80522794
26MAP3K41.71237983
27TAOK31.69252538
28VRK21.67262419
29MST41.67080119
30PINK11.61090088
31ARAF1.57837118
32EIF2AK31.47093783
33NUAK11.45564313
34FRK1.38839854
35CAMKK21.36428320
36STK38L1.35062789
37PIK3CA1.32236591
38TEC1.31996926
39PDK31.27983678
40PDK41.27983678
41BRSK21.27794724
42DAPK11.26786128
43MAP2K71.26104477
44IRAK31.25891026
45WNK41.18040636
46PKN21.14712519
47KDR1.09967457
48TLK11.09763919
49ZAK1.05909107
50STK241.04241794
51ADRBK21.03549260
52PRKG21.02869747
53KIT1.02061300
54BUB10.99172742
55VRK10.95732399
56ERN10.95713254
57IRAK20.94651944
58CDK80.93961274
59PDK20.92859292
60NEK10.92738822
61MAPKAPK50.92012717
62EIF2AK10.89690675
63TIE10.86030697
64MAPK110.85992617
65IRAK10.84074461
66PRKAA20.82993503
67MINK10.82292887
68CCNB10.80622106
69MAP2K60.80168757
70SRPK10.77545282
71CAMK2D0.75802592
72RPS6KA40.75335633
73TTN0.73402985
74TBK10.73118225
75BMPR1B0.72833766
76BTK0.72772629
77MAP3K50.72012212
78CAMK10.71420998
79CAMK2G0.71180446
80MAP2K30.69727484
81SIK30.67297257
82CDK190.67257020
83ABL20.65053562
84PIM20.65022325
85SCYL20.64717634
86GRK70.64283496
87DAPK30.63617013
88DYRK20.62479495
89IKBKB0.60686384
90MAP3K60.60228284
91TGFBR10.59717085
92WNK30.58898270
93GRK60.58438343
94MAP3K120.58128708
95PLK20.57655684
96DYRK30.55857658
97FES0.53299772
98PRKCE0.52004785
99PLK40.51469009
100TXK0.51229960
101MAPK120.51052974
102ILK0.50683266
103RAF10.50428793
104CDK140.49366669
105IRAK40.49341523
106MKNK10.48684415
107PLK10.48412849
108BLK0.48224305
109MAPK40.47841321
110DAPK20.47066436
111CSNK1A10.47000624
112CAMK40.46645163
113GRK10.46611766
114ZAP700.45296898
115NEK90.45286959
116EIF2AK20.45028032
117PLK30.44879839
118PRKAA10.44422412
119PASK0.43962985
120IKBKE0.41397570
121MAPKAPK30.41026743
122MST1R0.40393528
123MAPK150.40126878
124PRKACA0.39933613
125BRSK10.39715732
126MKNK20.39446321
127AURKB0.39086274
128CSF1R0.38644378
129LIMK10.38367984
130DYRK1B0.37758963
131BMPR20.37723049
132AURKA0.37217175
133MAP2K40.36958887
134SIK10.36584112
135CSNK2A20.35811763
136EPHA30.35744315
137NLK0.35664811
138WEE10.35144702
139TYK20.34777026
140FER0.34724054
141CAMK2A0.34574478
142GRK50.34308593
143BRAF0.34102383
144RPS6KA50.32361510
145CSNK2A10.31283152
146PAK60.30981956
147MAPK130.30245795
148PRKACG0.30197842
149LYN0.29529313
150ACVR1B0.29300339

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.80566732
2Oxidative phosphorylation_Homo sapiens_hsa001903.35062640
3Propanoate metabolism_Homo sapiens_hsa006403.19834546
4Parkinsons disease_Homo sapiens_hsa050123.12594845
5Fatty acid degradation_Homo sapiens_hsa000713.07120615
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.91395938
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.54169913
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.44009641
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.28382089
10Fatty acid metabolism_Homo sapiens_hsa012122.26073871
11Pyruvate metabolism_Homo sapiens_hsa006202.24588385
12Protein export_Homo sapiens_hsa030602.19537156
13Peroxisome_Homo sapiens_hsa041462.18957853
14Asthma_Homo sapiens_hsa053102.14916891
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.13250406
16Alzheimers disease_Homo sapiens_hsa050102.09823891
17Carbon metabolism_Homo sapiens_hsa012002.09346086
18Fatty acid elongation_Homo sapiens_hsa000622.06266060
19Sulfur metabolism_Homo sapiens_hsa009202.05733889
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.97662869
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.92750224
22Butanoate metabolism_Homo sapiens_hsa006501.91722075
23Huntingtons disease_Homo sapiens_hsa050161.88469322
24Tryptophan metabolism_Homo sapiens_hsa003801.75251773
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68746125
26Folate biosynthesis_Homo sapiens_hsa007901.68627848
27Cardiac muscle contraction_Homo sapiens_hsa042601.68051166
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64658945
29Ribosome_Homo sapiens_hsa030101.62969815
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.59825214
31Base excision repair_Homo sapiens_hsa034101.58254118
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.56749704
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.45548495
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.45433595
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.41034097
36Collecting duct acid secretion_Homo sapiens_hsa049661.41021345
37Type I diabetes mellitus_Homo sapiens_hsa049401.40113257
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.38567256
39Graft-versus-host disease_Homo sapiens_hsa053321.38503955
40Autoimmune thyroid disease_Homo sapiens_hsa053201.37316819
41Allograft rejection_Homo sapiens_hsa053301.36712829
42PPAR signaling pathway_Homo sapiens_hsa033201.35890973
43Proteasome_Homo sapiens_hsa030501.35045428
44beta-Alanine metabolism_Homo sapiens_hsa004101.33715933
45Biosynthesis of amino acids_Homo sapiens_hsa012301.32099299
46Starch and sucrose metabolism_Homo sapiens_hsa005001.31843863
47Sulfur relay system_Homo sapiens_hsa041221.30878000
48Rheumatoid arthritis_Homo sapiens_hsa053231.29365387
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26306088
50Nucleotide excision repair_Homo sapiens_hsa034201.22307900
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17937802
52Drug metabolism - other enzymes_Homo sapiens_hsa009831.16722021
53RNA degradation_Homo sapiens_hsa030181.13950433
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10520297
55Fructose and mannose metabolism_Homo sapiens_hsa000511.10434908
56Galactose metabolism_Homo sapiens_hsa000521.09911028
57Regulation of autophagy_Homo sapiens_hsa041401.09806318
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.08953547
59Nitrogen metabolism_Homo sapiens_hsa009101.05228796
60Arginine biosynthesis_Homo sapiens_hsa002201.05131984
61Metabolic pathways_Homo sapiens_hsa011000.97411361
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96655718
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94896229
64Pentose phosphate pathway_Homo sapiens_hsa000300.92664924
65Fanconi anemia pathway_Homo sapiens_hsa034600.92524243
66Arginine and proline metabolism_Homo sapiens_hsa003300.91736530
67Selenocompound metabolism_Homo sapiens_hsa004500.89153410
68Antigen processing and presentation_Homo sapiens_hsa046120.87541675
69Histidine metabolism_Homo sapiens_hsa003400.87107192
70Tyrosine metabolism_Homo sapiens_hsa003500.85771440
71Phenylalanine metabolism_Homo sapiens_hsa003600.83279738
72Basal transcription factors_Homo sapiens_hsa030220.82231548
73Pyrimidine metabolism_Homo sapiens_hsa002400.82120062
74Non-homologous end-joining_Homo sapiens_hsa034500.80216706
75Chemical carcinogenesis_Homo sapiens_hsa052040.78544673
76Spliceosome_Homo sapiens_hsa030400.76606632
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76298785
78Vibrio cholerae infection_Homo sapiens_hsa051100.75995175
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75328687
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73398071
81Caffeine metabolism_Homo sapiens_hsa002320.72524699
82One carbon pool by folate_Homo sapiens_hsa006700.72105835
83Phototransduction_Homo sapiens_hsa047440.72031139
84RNA transport_Homo sapiens_hsa030130.70274136
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70225144
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.67888530
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67266479
88Retinol metabolism_Homo sapiens_hsa008300.64987381
89Viral myocarditis_Homo sapiens_hsa054160.64560474
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64429362
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.63409906
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62761179
93RNA polymerase_Homo sapiens_hsa030200.62236953
94Synaptic vesicle cycle_Homo sapiens_hsa047210.59375372
95Glutathione metabolism_Homo sapiens_hsa004800.58909109
96Other glycan degradation_Homo sapiens_hsa005110.58278718
97Complement and coagulation cascades_Homo sapiens_hsa046100.58095827
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56372647
99Fatty acid biosynthesis_Homo sapiens_hsa000610.55078584
100ABC transporters_Homo sapiens_hsa020100.54958633
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51662404
102Primary immunodeficiency_Homo sapiens_hsa053400.49563397
103Shigellosis_Homo sapiens_hsa051310.48656950
104Purine metabolism_Homo sapiens_hsa002300.48630414
105Vitamin digestion and absorption_Homo sapiens_hsa049770.46970090
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46658896
107Glycerolipid metabolism_Homo sapiens_hsa005610.45820615
108Bile secretion_Homo sapiens_hsa049760.44477183
109Legionellosis_Homo sapiens_hsa051340.43881128
110DNA replication_Homo sapiens_hsa030300.40584014
111Fat digestion and absorption_Homo sapiens_hsa049750.39929728
112Lysosome_Homo sapiens_hsa041420.37899951
113Mismatch repair_Homo sapiens_hsa034300.37835052
114N-Glycan biosynthesis_Homo sapiens_hsa005100.35008569
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32991282
116Systemic lupus erythematosus_Homo sapiens_hsa053220.32020456
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31693366
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30952684
119Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.30490968
120Phagosome_Homo sapiens_hsa041450.30401316
121Arachidonic acid metabolism_Homo sapiens_hsa005900.29000252
122Steroid biosynthesis_Homo sapiens_hsa001000.24897304
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23569486
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23319273
125Linoleic acid metabolism_Homo sapiens_hsa005910.22471377
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22243138
127Glucagon signaling pathway_Homo sapiens_hsa049220.17384313
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.16393579
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16361875
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.13807836
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.12665656
132Insulin resistance_Homo sapiens_hsa049310.12643606
133Dilated cardiomyopathy_Homo sapiens_hsa054140.12570333
134Homologous recombination_Homo sapiens_hsa034400.12547642

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