PYROXD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand renaturation (GO:0000733)5.66302239
2signal peptide processing (GO:0006465)5.55615428
3mesenchymal cell differentiation involved in renal system development (GO:2001012)5.47536978
4mesenchymal cell differentiation involved in kidney development (GO:0072161)5.47536978
5cell differentiation involved in metanephros development (GO:0072202)5.27578443
6regulation of pigment cell differentiation (GO:0050932)4.93392448
7respiratory chain complex IV assembly (GO:0008535)4.42232114
8developmental pigmentation (GO:0048066)4.41418558
9protein targeting to Golgi (GO:0000042)4.20525753
10negative regulation of keratinocyte proliferation (GO:0010839)4.16515189
11establishment of protein localization to Golgi (GO:0072600)4.14482770
12cytochrome complex assembly (GO:0017004)4.08450642
13COPII vesicle coating (GO:0048208)4.02338453
14detection of light stimulus involved in sensory perception (GO:0050962)3.91305039
15detection of light stimulus involved in visual perception (GO:0050908)3.91305039
16auditory receptor cell differentiation (GO:0042491)3.91150964
17retrograde transport, vesicle recycling within Golgi (GO:0000301)3.75107484
18dopamine transport (GO:0015872)3.72350549
19desmosome organization (GO:0002934)3.70302614
20peptide hormone processing (GO:0016486)3.70178095
21DNA damage response, detection of DNA damage (GO:0042769)3.63532828
22fucose metabolic process (GO:0006004)3.60311064
23phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.51813788
24glycoside metabolic process (GO:0016137)3.46324969
25regulation of interleukin-8 secretion (GO:2000482)3.46314495
26glandular epithelial cell differentiation (GO:0002067)3.45386937
27Golgi transport vesicle coating (GO:0048200)3.42905336
28COPI coating of Golgi vesicle (GO:0048205)3.42905336
29interferon-gamma production (GO:0032609)3.41342359
30mannosylation (GO:0097502)3.35887738
31protein localization to Golgi apparatus (GO:0034067)3.35430680
32negative regulation of T cell mediated immunity (GO:0002710)3.32901325
33positive regulation of interleukin-8 secretion (GO:2000484)3.27089051
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.26090859
35regulation of B cell receptor signaling pathway (GO:0050855)3.25798429
36regulation of histone H3-K27 methylation (GO:0061085)3.25523996
37regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.25284341
38magnesium ion transport (GO:0015693)3.24300587
39tRNA methylation (GO:0030488)3.23995934
40positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.23804603
41indole-containing compound catabolic process (GO:0042436)3.22906259
42indolalkylamine catabolic process (GO:0046218)3.22906259
43tryptophan catabolic process (GO:0006569)3.22906259
44intraciliary transport (GO:0042073)3.21861964
45ER overload response (GO:0006983)3.16332400
46renal absorption (GO:0070293)3.16233222
47nucleoside diphosphate catabolic process (GO:0009134)3.15320216
48water-soluble vitamin biosynthetic process (GO:0042364)3.11249775
49adaptation of signaling pathway (GO:0023058)3.10862277
50mitotic sister chromatid cohesion (GO:0007064)3.07208187
51inner ear receptor cell differentiation (GO:0060113)3.07025505
52presynaptic membrane assembly (GO:0097105)3.06582277
53negative regulation of glycoprotein biosynthetic process (GO:0010561)3.04669628
54cytidine metabolic process (GO:0046087)3.01820936
55cytidine catabolic process (GO:0006216)3.01820936
56cytidine deamination (GO:0009972)3.01820936
57endocrine pancreas development (GO:0031018)3.00944596
58regulation of male gonad development (GO:2000018)3.00776048
59cellular copper ion homeostasis (GO:0006878)2.99000066
60nonmotile primary cilium assembly (GO:0035058)2.98767009
61tryptophan metabolic process (GO:0006568)2.96512022
62regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.93441568
63DNA deamination (GO:0045006)2.92810625
64positive regulation of vesicle fusion (GO:0031340)2.92272696
65tolerance induction (GO:0002507)2.91890438
66regulation of regulatory T cell differentiation (GO:0045589)2.91188532
67lactate metabolic process (GO:0006089)2.90976641
68peptidyl-histidine modification (GO:0018202)2.88650653
69dentate gyrus development (GO:0021542)2.87925638
70indolalkylamine metabolic process (GO:0006586)2.84333383
71sister chromatid cohesion (GO:0007062)2.83253160
72vascular smooth muscle contraction (GO:0014829)2.81750945
73intestinal epithelial cell development (GO:0060576)2.81021559
74sequestering of metal ion (GO:0051238)2.79517456
75positive regulation of granulocyte differentiation (GO:0030854)2.77394696
76artery smooth muscle contraction (GO:0014824)2.70944067
77regulation of alpha-beta T cell proliferation (GO:0046640)2.69875740
78negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.69693558
79regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.69050505
80iron ion import (GO:0097286)2.66882446
81keratinocyte development (GO:0003334)2.65795202
82response to redox state (GO:0051775)2.65509432
83positive regulation of hormone biosynthetic process (GO:0046886)2.64576995
84histone mRNA catabolic process (GO:0071044)2.63733443
85keratinocyte proliferation (GO:0043616)2.63662272
86vesicle fusion (GO:0006906)2.63233766
87purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.63048523
88RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.62717274
89tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.62717274
90cell differentiation involved in kidney development (GO:0061005)2.61902990
91positive regulation of interleukin-1 beta secretion (GO:0050718)2.61503465
92proteasome assembly (GO:0043248)2.61128102
93xenobiotic catabolic process (GO:0042178)2.60967557
94positive regulation of alpha-beta T cell proliferation (GO:0046641)2.60800541
95regulation of transforming growth factor beta1 production (GO:0032908)2.60714263
96protein K11-linked deubiquitination (GO:0035871)2.60171904
97regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.59371771
98negative regulation of glycoprotein metabolic process (GO:1903019)2.58890908
99protein complex biogenesis (GO:0070271)2.58869589
100negative regulation of activin receptor signaling pathway (GO:0032926)2.58516000
101cellular response to interleukin-15 (GO:0071350)2.57974594
102pyrimidine ribonucleoside catabolic process (GO:0046133)2.57857761
103positive regulation of gamma-delta T cell activation (GO:0046645)2.57827706
104negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.57783427
105mesenchyme morphogenesis (GO:0072132)2.57319716
106drug transmembrane transport (GO:0006855)2.55195362
107monoamine transport (GO:0015844)2.55035118
108production of molecular mediator of immune response (GO:0002440)2.54250294
109regulation of vitamin D biosynthetic process (GO:0060556)2.53803865
110protein neddylation (GO:0045116)2.53469259
111mesenchymal cell differentiation (GO:0048762)2.51726838
112response to nitrosative stress (GO:0051409)2.50967518
113positive regulation of cellular response to oxidative stress (GO:1900409)2.50171277
114positive regulation of response to oxidative stress (GO:1902884)2.50171277
115viral protein processing (GO:0019082)2.49994709
116preassembly of GPI anchor in ER membrane (GO:0016254)2.49741578
117monoubiquitinated protein deubiquitination (GO:0035520)2.48508004
118dopamine biosynthetic process (GO:0042416)2.47099011
119positive regulation of interleukin-1 secretion (GO:0050716)2.46987185
120regulation of T cell receptor signaling pathway (GO:0050856)2.46904667
121glucosamine-containing compound metabolic process (GO:1901071)2.44373714
122positive regulation of Cdc42 GTPase activity (GO:0043089)2.44093800
123antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.42502534
124deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.41995940
125regulation of interleukin-1 beta secretion (GO:0050706)2.41737418
126regulation of protein glycosylation (GO:0060049)2.41639965
127positive regulation of cellular amine metabolic process (GO:0033240)2.40869803
128protein autoprocessing (GO:0016540)2.40302848
129negative regulation of B cell activation (GO:0050869)2.40250790
130kynurenine metabolic process (GO:0070189)2.40071326
131regulation of oxidative phosphorylation (GO:0002082)2.39361800
132quinone biosynthetic process (GO:1901663)2.38888364
133ubiquinone biosynthetic process (GO:0006744)2.38888364
134nephron epithelium morphogenesis (GO:0072088)2.38480773
135nephron tubule morphogenesis (GO:0072078)2.38480773
136negative regulation of mast cell activation (GO:0033004)2.38445329
137nucleotide transmembrane transport (GO:1901679)2.38377801
138regulation of isotype switching to IgG isotypes (GO:0048302)2.38265058
139retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.37877974
140regulation of mitochondrial translation (GO:0070129)2.37821292
141T-helper cell differentiation (GO:0042093)2.37755560
142CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.37755560
143mitochondrial respiratory chain complex assembly (GO:0033108)2.36977084
144establishment of skin barrier (GO:0061436)2.36755680
145insulin secretion (GO:0030073)2.36719426
146positive regulation of protein autophosphorylation (GO:0031954)2.36647945
147platelet dense granule organization (GO:0060155)2.36592110
148positive regulation of hormone metabolic process (GO:0032352)2.36092255
149tonic smooth muscle contraction (GO:0014820)2.35911467
150regulation of T cell mediated cytotoxicity (GO:0001914)2.35856951
151regulation of fibroblast apoptotic process (GO:2000269)2.35606867
152polyol catabolic process (GO:0046174)2.35376903
153positive regulation of T-helper 1 type immune response (GO:0002827)2.35305328
154regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.35217075
155CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.35016240
156amine catabolic process (GO:0009310)2.35008089
157cellular biogenic amine catabolic process (GO:0042402)2.35008089
158antigen processing and presentation via MHC class Ib (GO:0002475)2.34774117
159axoneme assembly (GO:0035082)2.34617974
160necrotic cell death (GO:0070265)2.34423589
161negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.34385926
162sphingosine metabolic process (GO:0006670)2.34150400
163toxin transport (GO:1901998)2.33046107
164positive regulation of interleukin-12 production (GO:0032735)2.32691673
165glomerulus development (GO:0032835)2.32481712
166adenosine metabolic process (GO:0046085)2.32301731
167negative regulation of adaptive immune response (GO:0002820)2.29514962
168alpha-beta T cell differentiation (GO:0046632)2.29457685
169negative regulation of B cell proliferation (GO:0030889)2.29364330
170negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.28785229
171regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.28625671
172alpha-beta T cell activation (GO:0046631)2.27407722
173cilium or flagellum-dependent cell motility (GO:0001539)2.27313432
174regulation of germinal center formation (GO:0002634)2.26551816
175positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.25446193
176alpha-beta T cell differentiation involved in immune response (GO:0002293)2.25396097
177alpha-beta T cell activation involved in immune response (GO:0002287)2.25396097
178T cell differentiation involved in immune response (GO:0002292)2.25396097
179regulation of vitamin metabolic process (GO:0030656)2.25267246
180regulation of T cell tolerance induction (GO:0002664)2.24712955
181positive regulation of interleukin-1 beta production (GO:0032731)2.23917298
182regulation of inflammatory response to antigenic stimulus (GO:0002861)2.23601451
183I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.23142131
184negative regulation of lymphocyte mediated immunity (GO:0002707)2.21572185
185negative regulation of B cell mediated immunity (GO:0002713)2.21438719
186negative regulation of immunoglobulin mediated immune response (GO:0002890)2.21438719
187regulation of chronic inflammatory response (GO:0002676)2.21358579
188protein prenylation (GO:0018342)2.20988166
189prenylation (GO:0097354)2.20988166
190positive regulation of T cell mediated cytotoxicity (GO:0001916)2.20944362
191regulation of tolerance induction (GO:0002643)2.17409522
192snRNA transcription (GO:0009301)2.16226440
193regulation of T cell chemotaxis (GO:0010819)2.15443090

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse3.27354435
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.13486163
3FLI1_27457419_Chip-Seq_LIVER_Mouse3.06070482
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.02967590
5PCGF2_27294783_Chip-Seq_ESCs_Mouse2.77324000
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.49209871
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.47135816
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42119200
9IGF1R_20145208_ChIP-Seq_DFB_Human2.31409510
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.29762711
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.29306205
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.28039969
13ELK1_19687146_ChIP-ChIP_HELA_Human2.19596792
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15268318
15SUZ12_27294783_Chip-Seq_NPCs_Mouse2.11226460
16VDR_22108803_ChIP-Seq_LS180_Human2.10709818
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09512750
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.06827305
19EZH2_27294783_Chip-Seq_NPCs_Mouse2.06283573
20NFE2_27457419_Chip-Seq_LIVER_Mouse2.03926516
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.00994675
22FUS_26573619_Chip-Seq_HEK293_Human1.95966817
23NANOG_18555785_Chip-Seq_ESCs_Mouse1.90104970
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.89745272
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.89398227
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.89256881
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.89169195
28TP53_18474530_ChIP-ChIP_U2OS_Human1.87481702
29TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.87164579
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.86473948
31FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.83796781
32EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.82259400
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78776440
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.76307588
35P53_22387025_ChIP-Seq_ESCs_Mouse1.70321917
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.69870866
37SUZ12_18555785_Chip-Seq_ESCs_Mouse1.68417540
38RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.68168346
39E2F1_18555785_Chip-Seq_ESCs_Mouse1.65632879
40EGR1_23403033_ChIP-Seq_LIVER_Mouse1.64071282
41CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.63302543
42BCAT_22108803_ChIP-Seq_LS180_Human1.62380233
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.61693083
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60553926
45GATA3_26560356_Chip-Seq_TH2_Human1.60540623
46EWS_26573619_Chip-Seq_HEK293_Human1.60233009
47OCT4_18555785_Chip-Seq_ESCs_Mouse1.57883466
48ZNF274_21170338_ChIP-Seq_K562_Hela1.57636347
49CRX_20693478_ChIP-Seq_RETINA_Mouse1.56865068
50NMYC_18555785_Chip-Seq_ESCs_Mouse1.55851706
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54140900
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52563021
53P300_19829295_ChIP-Seq_ESCs_Human1.52380051
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.48427089
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.47778216
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.47778216
57* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46627574
58IRF8_27001747_Chip-Seq_BMDM_Mouse1.46013045
59CMYC_18555785_Chip-Seq_ESCs_Mouse1.44793636
60TP53_16413492_ChIP-PET_HCT116_Human1.43933170
61ER_23166858_ChIP-Seq_MCF-7_Human1.43269833
62STAT3_18555785_Chip-Seq_ESCs_Mouse1.42961527
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.42817985
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41690359
65RUNX1_27457419_Chip-Seq_LIVER_Mouse1.40174468
66OCT4_21477851_ChIP-Seq_ESCs_Mouse1.39872481
67STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39531439
68EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.38543870
69TAF15_26573619_Chip-Seq_HEK293_Human1.37708198
70SOX2_18555785_Chip-Seq_ESCs_Mouse1.36962495
71MYB_26560356_Chip-Seq_TH2_Human1.36422120
72ZFX_18555785_Chip-Seq_ESCs_Mouse1.36419415
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.36334559
74CDX2_22108803_ChIP-Seq_LS180_Human1.36121238
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35662000
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35490451
77P300_18555785_Chip-Seq_ESCs_Mouse1.35074406
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34039785
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31926576
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.31787567
81SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.30564794
82PU1_27457419_Chip-Seq_LIVER_Mouse1.30311748
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29021334
84NANOG_19829295_ChIP-Seq_ESCs_Human1.27755318
85SOX2_19829295_ChIP-Seq_ESCs_Human1.27755318
86STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25515692
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25185363
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24883319
89RUNX_20019798_ChIP-Seq_JUKART_Human1.24847633
90FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24432295
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24012460
92CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23978810
93KLF4_18555785_Chip-Seq_ESCs_Mouse1.23495669
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.22934308
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22115760
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22105754
97CBP_20019798_ChIP-Seq_JUKART_Human1.22105754
98SMAD1_18555785_Chip-Seq_ESCs_Mouse1.21889257
99HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20003771
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.18479678
101ESRRB_18555785_Chip-Seq_ESCs_Mouse1.17015167
102FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16654914
103PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16620920
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15102195
105SMAD4_21799915_ChIP-Seq_A2780_Human1.14740577
106BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14187227
107CTCF_18555785_Chip-Seq_ESCs_Mouse1.13777208
108FLI1_21867929_ChIP-Seq_TH2_Mouse1.12480596
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12368181
110CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11705989
111TP53_22573176_ChIP-Seq_HFKS_Human1.10055406
112HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09467359
113TCF4_22108803_ChIP-Seq_LS180_Human1.09330900
114PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09270793
115FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08885913
116FOXA1_25329375_ChIP-Seq_VCAP_Human1.08885913
117EST1_17652178_ChIP-ChIP_JURKAT_Human1.07318132
118AR_25329375_ChIP-Seq_VCAP_Human1.06863550
119NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06797671
120CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06515036
121STAT3_23295773_ChIP-Seq_U87_Human1.05401439
122GATA1_22025678_ChIP-Seq_K562_Human1.05212951
123GBX2_23144817_ChIP-Seq_PC3_Human1.04855142
124GATA3_27048872_Chip-Seq_THYMUS_Human1.04456402
125PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03354000
126LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02692608
127SOX2_20726797_ChIP-Seq_SW620_Human1.02625523
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00618090
129CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00596317
130VDR_23849224_ChIP-Seq_CD4+_Human1.00444433
131BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00075359
132CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98608121
133MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97198231

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.89910708
2MP0000569_abnormal_digit_pigmentation4.59340820
3MP0010234_abnormal_vibrissa_follicle3.50535139
4MP0001188_hyperpigmentation3.45716241
5MP0003941_abnormal_skin_development3.11682354
6MP0002009_preneoplasia2.99883859
7MP0005379_endocrine/exocrine_gland_phen2.96065407
8MP0001986_abnormal_taste_sensitivity2.95466802
9MP0010386_abnormal_urinary_bladder2.87011954
10MP0002139_abnormal_hepatobiliary_system2.74929046
11MP0000566_synostosis2.56165043
12MP0005409_darkened_coat_color2.51356436
13MP0002876_abnormal_thyroid_physiology2.48371058
14MP0004147_increased_porphyrin_level2.44735801
15MP0003195_calcinosis2.43763701
16MP0002877_abnormal_melanocyte_morpholog2.31511879
17MP0002254_reproductive_system_inflammat2.28363179
18MP0009785_altered_susceptibility_to2.25638402
19MP0002837_dystrophic_cardiac_calcinosis2.22438467
20MP0003656_abnormal_erythrocyte_physiolo2.20274447
21MP0004043_abnormal_pH_regulation2.15832574
22MP0003252_abnormal_bile_duct2.07165934
23MP0002928_abnormal_bile_duct2.03815252
24MP0005174_abnormal_tail_pigmentation1.97954095
25MP0001873_stomach_inflammation1.97728695
26MP0002163_abnormal_gland_morphology1.93863696
27MP0001346_abnormal_lacrimal_gland1.91560583
28MP0005220_abnormal_exocrine_pancreas1.89804008
29MP0005000_abnormal_immune_tolerance1.87170417
30MP0000015_abnormal_ear_pigmentation1.85431202
31MP0002723_abnormal_immune_serum1.77067451
32MP0002693_abnormal_pancreas_physiology1.69641465
33MP0010155_abnormal_intestine_physiology1.67921275
34MP0005085_abnormal_gallbladder_physiolo1.67664055
35MP0001944_abnormal_pancreas_morphology1.67535618
36MP0002452_abnormal_antigen_presenting1.67217607
37MP0004381_abnormal_hair_follicle1.66001956
38MP0002098_abnormal_vibrissa_morphology1.60101357
39MP0003950_abnormal_plasma_membrane1.59104505
40MP0009697_abnormal_copulation1.58337047
41MP0003806_abnormal_nucleotide_metabolis1.57987438
42MP0006082_CNS_inflammation1.57804080
43MP0003724_increased_susceptibility_to1.55627250
44MP0004782_abnormal_surfactant_physiolog1.55443006
45MP0005645_abnormal_hypothalamus_physiol1.54128185
46MP0001919_abnormal_reproductive_system1.53579714
47MP0002420_abnormal_adaptive_immunity1.47263511
48MP0008057_abnormal_DNA_replication1.46994538
49MP0002796_impaired_skin_barrier1.45543494
50MP0001819_abnormal_immune_cell1.45060760
51MP0002166_altered_tumor_susceptibility1.44398076
52MP0001845_abnormal_inflammatory_respons1.42767838
53MP0005365_abnormal_bile_salt1.41449323
54MP0003763_abnormal_thymus_physiology1.40941738
55MP0003866_abnormal_defecation1.39538776
56MP0001984_abnormal_olfaction1.37684337
57MP0002405_respiratory_system_inflammati1.35563293
58MP0008872_abnormal_physiological_respon1.35490391
59MP0002138_abnormal_hepatobiliary_system1.35344408
60MP0000678_abnormal_parathyroid_gland1.35262696
61MP0002909_abnormal_adrenal_gland1.31976027
62MP0000538_abnormal_urinary_bladder1.29669434
63MP0001501_abnormal_sleep_pattern1.27342526
64MP0001835_abnormal_antigen_presentation1.25239948
65MP0005084_abnormal_gallbladder_morpholo1.24545510
66MP0005025_abnormal_response_to1.24519318
67MP0002419_abnormal_innate_immunity1.22601151
68MP0009764_decreased_sensitivity_to1.20017384
69MP0010352_gastrointestinal_tract_polyps1.18666994
70MP0002095_abnormal_skin_pigmentation1.17350932
71MP0009780_abnormal_chondrocyte_physiolo1.15526950
72MP0008469_abnormal_protein_level1.14203212
73MP0000427_abnormal_hair_cycle1.13394462
74MP0001790_abnormal_immune_system1.13390555
75MP0005387_immune_system_phenotype1.13390555
76MP0002006_tumorigenesis1.13061257
77MP0008875_abnormal_xenobiotic_pharmacok1.13020545
78MP0008789_abnormal_olfactory_epithelium1.12602032
79MP0002398_abnormal_bone_marrow1.12142314
80MP0006036_abnormal_mitochondrial_physio1.10657323
81MP0000716_abnormal_immune_system1.10308236
82MP0005310_abnormal_salivary_gland1.09170658
83MP0003183_abnormal_peptide_metabolism1.07050490
84MP0002177_abnormal_outer_ear1.06924118
85MP0005257_abnormal_intraocular_pressure1.06502971
86MP0004019_abnormal_vitamin_homeostasis1.03712802
87MP0006072_abnormal_retinal_apoptosis1.02613270
88MP0005408_hypopigmentation1.02411447
89MP0001666_abnormal_nutrient_absorption1.02154854
90MP0010678_abnormal_skin_adnexa1.01235783
91MP0000689_abnormal_spleen_morphology1.01182290
92MP0005075_abnormal_melanosome_morpholog1.00741348
93MP0002896_abnormal_bone_mineralization1.00604299
94MP0002060_abnormal_skin_morphology1.00158842
95MP0004484_altered_response_of0.99688501
96MP0000049_abnormal_middle_ear0.99289259
97MP0005166_decreased_susceptibility_to0.98800122
98MP0002148_abnormal_hypersensitivity_rea0.98712351
99MP0002396_abnormal_hematopoietic_system0.95788161
100MP0000465_gastrointestinal_hemorrhage0.95656578
101MP0003045_fibrosis0.95490257
102MP0003646_muscle_fatigue0.93491793
103MP0003868_abnormal_feces_composition0.92722994
104MP0002277_abnormal_respiratory_mucosa0.92679631
105MP0001186_pigmentation_phenotype0.92490157
106MP0000372_irregular_coat_pigmentation0.92395929
107MP0001853_heart_inflammation0.91956670
108MP0005389_reproductive_system_phenotype0.90300058
109MP0002136_abnormal_kidney_physiology0.89359101
110MP0001756_abnormal_urination0.88553843
111MP0005636_abnormal_mineral_homeostasis0.87629908
112MP0004215_abnormal_myocardial_fiber0.86232784
113MP0004264_abnormal_extraembryonic_tissu0.85253523
114MP0009333_abnormal_splenocyte_physiolog0.84724588
115MP0005394_taste/olfaction_phenotype0.84442112
116MP0005499_abnormal_olfactory_system0.84442112
117MP0001216_abnormal_epidermal_layer0.83812388
118MP0001299_abnormal_eye_distance/0.83681853
119MP0003436_decreased_susceptibility_to0.81850919
120MP0000230_abnormal_systemic_arterial0.79313026
121MP0001765_abnormal_ion_homeostasis0.78994817
122MP0008877_abnormal_DNA_methylation0.78221211
123MP0000762_abnormal_tongue_morphology0.77427769
124MP0002722_abnormal_immune_system0.77193651
125MP0006054_spinal_hemorrhage0.77140913
126MP0003011_delayed_dark_adaptation0.76835092
127MP0000383_abnormal_hair_follicle0.76084293
128MP0003186_abnormal_redox_activity0.75236123
129MP0004883_abnormal_blood_vessel0.75054874
130MP0002429_abnormal_blood_cell0.75033595
131MP0005551_abnormal_eye_electrophysiolog0.74993461
132MP0000685_abnormal_immune_system0.73875292
133MP0002160_abnormal_reproductive_system0.72586014
134MP0006276_abnormal_autonomic_nervous0.72401443
135MP0001851_eye_inflammation0.72337754
136MP0006035_abnormal_mitochondrial_morpho0.71608700
137MP0009384_cardiac_valve_regurgitation0.70260953
138MP0002933_joint_inflammation0.69434439
139MP0003787_abnormal_imprinting0.66428563
140MP0001905_abnormal_dopamine_level0.65436116
141MP0008058_abnormal_DNA_repair0.64116835
142MP0000613_abnormal_salivary_gland0.63095034
143MP0001800_abnormal_humoral_immune0.61810424
144MP0005671_abnormal_response_to0.61611547
145MP0001764_abnormal_homeostasis0.60737880
146MP0005332_abnormal_amino_acid0.60473929
147MP0003453_abnormal_keratinocyte_physiol0.60051569
148MP0003786_premature_aging0.59803732
149MP0009643_abnormal_urine_homeostasis0.58405747
150MP0000631_abnormal_neuroendocrine_gland0.58237627
151MP0003795_abnormal_bone_structure0.57396413
152MP0001324_abnormal_eye_pigmentation0.57028895

Predicted human phenotypes

RankGene SetZ-score
1Lip pit (HP:0100267)3.61929391
2Aplasia/hypoplasia of the uterus (HP:0008684)3.48124639
3Type I transferrin isoform profile (HP:0003642)3.40989615
411 pairs of ribs (HP:0000878)3.39752118
5True hermaphroditism (HP:0010459)3.28512114
6Abnormal protein glycosylation (HP:0012346)3.28315004
7Abnormal glycosylation (HP:0012345)3.28315004
8Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.28315004
9Abnormal protein N-linked glycosylation (HP:0012347)3.28315004
10Symptomatic seizures (HP:0011145)3.19603896
11Pancreatic fibrosis (HP:0100732)3.19228805
12Hypoglycemic seizures (HP:0002173)3.10587644
13Hypothermia (HP:0002045)3.04222329
14Stomatitis (HP:0010280)2.99855675
15Chronic hepatic failure (HP:0100626)2.94819056
16Dynein arm defect of respiratory motile cilia (HP:0012255)2.93949884
17Absent/shortened dynein arms (HP:0200106)2.93949884
18Congenital sensorineural hearing impairment (HP:0008527)2.93937515
19Fibular aplasia (HP:0002990)2.92376284
20Molar tooth sign on MRI (HP:0002419)2.92073884
21Abnormality of midbrain morphology (HP:0002418)2.92073884
22Thyroiditis (HP:0100646)2.90019651
23Renal cortical cysts (HP:0000803)2.81193326
24Methylmalonic acidemia (HP:0002912)2.80497990
25Exertional dyspnea (HP:0002875)2.78461485
26Abnormality of the pons (HP:0007361)2.77527028
27IgG deficiency (HP:0004315)2.72707400
28Abnormality of B cell number (HP:0010975)2.71592325
29B lymphocytopenia (HP:0010976)2.61413519
30Abnormality of the axillary hair (HP:0100134)2.60717242
31Abnormality of secondary sexual hair (HP:0009888)2.60717242
32Retrobulbar optic neuritis (HP:0100654)2.59754061
33Optic neuritis (HP:0100653)2.59754061
34Chronic diarrhea (HP:0002028)2.55823827
35Increased hepatocellular lipid droplets (HP:0006565)2.54085513
36Unilateral renal agenesis (HP:0000122)2.52634712
373-Methylglutaconic aciduria (HP:0003535)2.51949450
38Abnormality of renal resorption (HP:0011038)2.51137087
39Hyperphosphatemia (HP:0002905)2.50639978
40Lipid accumulation in hepatocytes (HP:0006561)2.48222083
41Abnormality of calcium-phosphate metabolism (HP:0100530)2.48216187
42Abnormality of vitamin B metabolism (HP:0004340)2.47874746
43Hypoplastic labia majora (HP:0000059)2.46730904
44Hypoplasia of the pons (HP:0012110)2.44450965
45Fair hair (HP:0002286)2.43892966
46Pancreatic cysts (HP:0001737)2.43816734
47Hyperglycemia (HP:0003074)2.40360002
48Hyperventilation (HP:0002883)2.39030516
49Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.38489642
50Abnormality of T cell number (HP:0011839)2.38025491
51Severe combined immunodeficiency (HP:0004430)2.35167781
52Azoospermia (HP:0000027)2.30836375
53Congenital, generalized hypertrichosis (HP:0004540)2.30393394
54Abnormal rod and cone electroretinograms (HP:0008323)2.30056292
55Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.29861410
56Abnormality of the vitamin B12 metabolism (HP:0004341)2.29018741
57Popliteal pterygium (HP:0009756)2.28947673
58Alveolar cell carcinoma (HP:0006519)2.25508266
59Abnormal respiratory epithelium morphology (HP:0012253)2.24672291
60Abnormal respiratory motile cilium morphology (HP:0005938)2.24672291
61Occipital encephalocele (HP:0002085)2.23685944
62Methylmalonic aciduria (HP:0012120)2.22005545
63T lymphocytopenia (HP:0005403)2.21153241
64Renal tubular dysfunction (HP:0000124)2.20916986
65Respiratory difficulties (HP:0002880)2.20761813
66Autoimmune hemolytic anemia (HP:0001890)2.20715278
67Decreased circulating renin level (HP:0003351)2.20356714
68Natal tooth (HP:0000695)2.20171212
69Abnormality of the labia majora (HP:0012881)2.19626204
70Acute hepatic failure (HP:0006554)2.18408858
71Severe visual impairment (HP:0001141)2.18286555
72Hypoplasia of the thymus (HP:0000778)2.15766104
73Conjugated hyperbilirubinemia (HP:0002908)2.14956593
74Orchitis (HP:0100796)2.14216101
75Hypoproteinemia (HP:0003075)2.13922754
76Sex reversal (HP:0012245)2.13158460
77Abnormal sex determination (HP:0012244)2.13158460
78Absent eyebrow (HP:0002223)2.12756153
79Mitochondrial inheritance (HP:0001427)2.11937244
80Aplasia/Hypoplasia of the tibia (HP:0005772)2.11855283
81Medial flaring of the eyebrow (HP:0010747)2.10931401
82Osteomalacia (HP:0002749)2.10590300
83Large for gestational age (HP:0001520)2.08226020
84Intrahepatic cholestasis (HP:0001406)2.06095892
85Abnormal spermatogenesis (HP:0008669)2.06044289
86Abnormality of eosinophils (HP:0001879)2.05169130
87Abnormal hemoglobin (HP:0011902)2.04957603
88Short tibia (HP:0005736)2.04920564
89Abnormality of urine glucose concentration (HP:0011016)2.03609704
90Glycosuria (HP:0003076)2.03609704
91Recurrent sinusitis (HP:0011108)2.02623026
92Chronic sinusitis (HP:0011109)2.01388305
93Hypoplasia of the uterus (HP:0000013)2.00829096
94Myositis (HP:0100614)1.99973480
95Hypoglycemic coma (HP:0001325)1.99688198
96Neoplasm of the tracheobronchial system (HP:0100552)1.99676845
97Ketoacidosis (HP:0001993)1.99258319
98Constricted visual fields (HP:0001133)1.98147213
99Keratoconjunctivitis (HP:0001096)1.96529810
100Widely spaced teeth (HP:0000687)1.96137573
101Aplasia/Hypoplasia of the tongue (HP:0010295)1.96100397
102Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.95527765
103Abnormal albumin level (HP:0012116)1.95254594
104Hypoalbuminemia (HP:0003073)1.95254594
105Renal Fanconi syndrome (HP:0001994)1.95127644
106Conjunctival hamartoma (HP:0100780)1.94733949
107Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94187520
108Abnormality of incisor morphology (HP:0011063)1.92190832
109Aplasia/Hypoplasia of the fibula (HP:0006492)1.91851500
110Albinism (HP:0001022)1.89997430
111Microvesicular hepatic steatosis (HP:0001414)1.89797243
112Dysautonomia (HP:0002459)1.89450390
113Eosinophilia (HP:0001880)1.89377838
114Abnormality of the right ventricle (HP:0001707)1.89159756
115Generalized hypopigmentation of hair (HP:0011358)1.89095010
116Encephalitis (HP:0002383)1.88631997
117Hyperkalemia (HP:0002153)1.87474164
118Combined immunodeficiency (HP:0005387)1.87271042
119Labial hypoplasia (HP:0000066)1.87032133
120Hepatic necrosis (HP:0002605)1.86860152
121Abnormal ciliary motility (HP:0012262)1.86736592
122Keratoconjunctivitis sicca (HP:0001097)1.86555460
123Hypokalemic alkalosis (HP:0001949)1.86081862
124Fibular hypoplasia (HP:0003038)1.85237775
125Chronic otitis media (HP:0000389)1.85006203
126Fat malabsorption (HP:0002630)1.83960694
127Facial diplegia (HP:0001349)1.83542468
128Metabolic alkalosis (HP:0200114)1.83296966
129Abnormal delayed hypersensitivity skin test (HP:0002963)1.82197094
130Abnormality of the renal cortex (HP:0011035)1.81763800
131Genital tract atresia (HP:0001827)1.80830280
132Rough bone trabeculation (HP:0100670)1.80346968
133Irregular vertebral endplates (HP:0003301)1.80112081
134Vasculitis (HP:0002633)1.79943082
135Progressive macrocephaly (HP:0004481)1.79045506
136Recurrent bronchitis (HP:0002837)1.78896153
137Renal tubular acidosis (HP:0001947)1.78172285
138Increased CSF lactate (HP:0002490)1.77421403
139Abnormality of vitamin metabolism (HP:0100508)1.77352663
140IgM deficiency (HP:0002850)1.77328036
141Insulin-resistant diabetes mellitus (HP:0000831)1.77097576
142Ketosis (HP:0001946)1.75287799
143Acute necrotizing encephalopathy (HP:0006965)1.75157468
144Dyschromatopsia (HP:0007641)1.74556141
145Hyperphosphaturia (HP:0003109)1.74169079
146Hyperinsulinemic hypoglycemia (HP:0000825)1.74127579
147Hematochezia (HP:0002573)1.73746242
148Congenital stationary night blindness (HP:0007642)1.73594270
149Barrel-shaped chest (HP:0001552)1.73516170
150Onycholysis (HP:0001806)1.73213326
151Abnormal biliary tract morphology (HP:0012440)1.73172111
152Furrowed tongue (HP:0000221)1.72816137
153Abnormal hair whorl (HP:0010721)1.72368671
154Pulmonary infiltrates (HP:0002113)1.71984052
155Cystic liver disease (HP:0006706)1.70956943
156Anal stenosis (HP:0002025)1.70806138
157Hepatocellular necrosis (HP:0001404)1.70487870
158Abnormality of T cells (HP:0002843)1.69399032
159Congenital primary aphakia (HP:0007707)1.68189541
160Vaginal atresia (HP:0000148)1.67105861
161Cerebral edema (HP:0002181)1.66933428
162Broad-based gait (HP:0002136)1.66689765
163Abnormality of alanine metabolism (HP:0010916)1.66149060
164Hyperalaninemia (HP:0003348)1.66149060
165Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66149060
166Missing ribs (HP:0000921)1.66061421
167Urethral obstruction (HP:0000796)1.65872237
168Median cleft lip (HP:0000161)1.64305970
169Postaxial foot polydactyly (HP:0001830)1.62671518
170Tubulointerstitial nephritis (HP:0001970)1.62310624
171Mediastinal lymphadenopathy (HP:0100721)1.61939420
172Eczematoid dermatitis (HP:0000976)1.61130408
173Metaphyseal dysplasia (HP:0100255)1.60471311
174Vitreoretinal degeneration (HP:0000655)1.59820421

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.24564256
2BMPR1B3.07017736
3CAMKK22.44252312
4EIF2AK32.35583497
5CDK192.34069858
6TAOK22.31537901
7IRAK32.29069169
8ERBB32.13610541
9MAP3K32.12843619
10TXK2.07938242
11MAP3K142.06439472
12TRIM282.06176026
13EPHA32.02032522
14RIPK42.00315746
15CASK1.97411999
16INSRR1.96835277
17NLK1.87443996
18IRAK11.83790004
19MST41.81774303
20MAP4K11.77001203
21BRD41.73509147
22PINK11.73077978
23PBK1.73058703
24MAP2K61.72471463
25OXSR11.67982163
26STK391.66323947
27YES11.64089048
28ZAK1.56635403
29MKNK21.54742218
30GRK11.49331768
31IKBKB1.46763225
32FGFR31.44152313
33BMPR21.42958534
34MAP4K21.42379246
35WNK41.33256859
36BUB11.29207984
37BRSK21.27863187
38CDK31.26823452
39ZAP701.26226065
40EPHB21.24918298
41TGFBR21.23894582
42MAP2K31.20632780
43TEC1.19338409
44STK161.14632114
45MST1R1.13210264
46BCKDK1.12160507
47MKNK11.08945801
48DYRK1B1.08512811
49PASK1.05550175
50NUAK11.03549887
51DYRK1A1.03211074
52CCNB11.02679201
53ACVR1B1.02347777
54IKBKE1.01922808
55SIK31.01915677
56CDK81.00567136
57BLK0.99047464
58STK38L0.97285712
59FER0.96493903
60GRK70.94591698
61NEK60.91872513
62SGK20.90788531
63STK240.90639213
64SRPK10.90630293
65WNK30.87577207
66MAP3K20.87237382
67CDC70.86336122
68MAPK150.86098555
69TRPM70.81551611
70MARK30.80600802
71TAF10.79422786
72MAP3K120.79161895
73AKT30.78667170
74NME10.78627340
75PLK30.78359867
76PIK3CG0.75749577
77IRAK40.75600352
78ADRBK20.75072711
79STK30.73590714
80TLK10.73443048
81TNIK0.72047745
82FLT30.71699630
83TAOK30.71578097
84JAK30.70144717
85EPHA20.67268862
86ITK0.65798346
87NEK10.65174911
88EIF2AK10.64804545
89MAPK130.61885887
90STK100.61504629
91NEK90.61501028
92FGFR40.60121169
93OBSCN0.60016767
94SYK0.58809055
95CSF1R0.58764658
96LYN0.58567135
97WNK10.58374505
98MYLK0.57940493
99PRKCE0.56938127
100EIF2AK20.55864909
101JAK10.55113457
102TNK20.54763068
103PDK20.52132098
104RPS6KA40.51653375
105KIT0.51437809
106BTK0.50255932
107MAP3K50.49416939
108CHUK0.49270484
109PRKCQ0.47959527
110LCK0.47406084
111ATR0.46218972
112ERBB20.45755210
113CSK0.45140334
114PIK3CA0.44817185
115GRK60.44549287
116MAP3K130.44394624
117PLK20.44138753
118ADRBK10.44107494
119TYK20.43633399
120PHKG20.43534363
121PHKG10.43534363
122AURKB0.42573700
123MET0.41536080
124IGF1R0.41318426
125HIPK20.41309092
126BCR0.40837099
127HCK0.40750917
128ABL10.36636770
129IRAK20.36218013
130PAK30.35313888
131SCYL20.35148855
132CSNK1G10.34947024
133TESK10.31441235
134CSNK1A10.31413030
135SGK10.31180812
136PIM10.30104169
137ATM0.29924491
138PRKCI0.29716212
139CSNK1G20.29117917
140PRKAA20.29036728
141TBK10.28352713
142PRKCD0.28271446

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030606.71756801
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.29049288
3Homologous recombination_Homo sapiens_hsa034403.27154900
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.16223378
5Sulfur metabolism_Homo sapiens_hsa009202.40823064
6Non-homologous end-joining_Homo sapiens_hsa034502.25302419
7Proteasome_Homo sapiens_hsa030502.20409850
8N-Glycan biosynthesis_Homo sapiens_hsa005101.95781254
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87671540
10Mismatch repair_Homo sapiens_hsa034301.67939537
11Oxidative phosphorylation_Homo sapiens_hsa001901.61423430
12Peroxisome_Homo sapiens_hsa041461.58941985
13ABC transporters_Homo sapiens_hsa020101.51421344
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.50769477
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.48907959
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.43601135
17Fanconi anemia pathway_Homo sapiens_hsa034601.43548590
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.41413772
19Folate biosynthesis_Homo sapiens_hsa007901.40844315
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.37401474
21RNA degradation_Homo sapiens_hsa030181.36926024
22Tyrosine metabolism_Homo sapiens_hsa003501.36525904
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31833870
24Caffeine metabolism_Homo sapiens_hsa002321.28187046
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.27727157
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21125287
27Phenylalanine metabolism_Homo sapiens_hsa003601.21031355
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.20575942
29Chemical carcinogenesis_Homo sapiens_hsa052041.20358495
30Nitrogen metabolism_Homo sapiens_hsa009101.20131110
31Starch and sucrose metabolism_Homo sapiens_hsa005001.18771276
32T cell receptor signaling pathway_Homo sapiens_hsa046601.18231121
33Staphylococcus aureus infection_Homo sapiens_hsa051501.17794099
34Ribosome_Homo sapiens_hsa030101.15442788
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.11703944
36Type I diabetes mellitus_Homo sapiens_hsa049401.11491292
37Renin-angiotensin system_Homo sapiens_hsa046141.10787576
38Butanoate metabolism_Homo sapiens_hsa006501.10551709
39Parkinsons disease_Homo sapiens_hsa050121.09083477
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07714366
41Sphingolipid metabolism_Homo sapiens_hsa006001.06835890
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05655698
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.05628488
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05497364
45Dorso-ventral axis formation_Homo sapiens_hsa043201.03673562
46Ether lipid metabolism_Homo sapiens_hsa005651.01603187
47Cocaine addiction_Homo sapiens_hsa050300.97220931
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95878732
49Hematopoietic cell lineage_Homo sapiens_hsa046400.95734468
50Osteoclast differentiation_Homo sapiens_hsa043800.95713267
51Propanoate metabolism_Homo sapiens_hsa006400.94723804
52Insulin secretion_Homo sapiens_hsa049110.94410284
53Galactose metabolism_Homo sapiens_hsa000520.92338124
54Mineral absorption_Homo sapiens_hsa049780.90379072
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89626788
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89321820
57Circadian rhythm_Homo sapiens_hsa047100.88150874
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87849563
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.85588412
60RNA polymerase_Homo sapiens_hsa030200.85566086
61Selenocompound metabolism_Homo sapiens_hsa004500.85315721
62Collecting duct acid secretion_Homo sapiens_hsa049660.84205560
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83356887
64Viral myocarditis_Homo sapiens_hsa054160.82324674
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82182399
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81422366
67Other glycan degradation_Homo sapiens_hsa005110.80702625
68Vibrio cholerae infection_Homo sapiens_hsa051100.80472206
69Primary immunodeficiency_Homo sapiens_hsa053400.79985641
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79940790
71Tuberculosis_Homo sapiens_hsa051520.79809319
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78722576
73Legionellosis_Homo sapiens_hsa051340.77984966
74Basal transcription factors_Homo sapiens_hsa030220.77924176
75Amphetamine addiction_Homo sapiens_hsa050310.77810112
76B cell receptor signaling pathway_Homo sapiens_hsa046620.76476704
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76294847
78Histidine metabolism_Homo sapiens_hsa003400.76025500
79TNF signaling pathway_Homo sapiens_hsa046680.75077314
80Vitamin digestion and absorption_Homo sapiens_hsa049770.74725279
81Alzheimers disease_Homo sapiens_hsa050100.69919753
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.69600638
83Antigen processing and presentation_Homo sapiens_hsa046120.68005045
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.66475350
85Fatty acid degradation_Homo sapiens_hsa000710.65509142
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63939080
87One carbon pool by folate_Homo sapiens_hsa006700.63643191
88Pyrimidine metabolism_Homo sapiens_hsa002400.62086685
89Huntingtons disease_Homo sapiens_hsa050160.61970581
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60943085
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60388606
92African trypanosomiasis_Homo sapiens_hsa051430.59659574
93Rheumatoid arthritis_Homo sapiens_hsa053230.59557181
94Measles_Homo sapiens_hsa051620.59009102
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58818571
96Retinol metabolism_Homo sapiens_hsa008300.57708909
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57373388
98Allograft rejection_Homo sapiens_hsa053300.56068918
99Pentose phosphate pathway_Homo sapiens_hsa000300.56050367
100Fatty acid biosynthesis_Homo sapiens_hsa000610.55993340
101Graft-versus-host disease_Homo sapiens_hsa053320.55152508
102Metabolic pathways_Homo sapiens_hsa011000.54555794
103Epstein-Barr virus infection_Homo sapiens_hsa051690.49167864
104Glutathione metabolism_Homo sapiens_hsa004800.47558755
105Influenza A_Homo sapiens_hsa051640.47546629
106Regulation of autophagy_Homo sapiens_hsa041400.47340585
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46474690
108DNA replication_Homo sapiens_hsa030300.46045235
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43776756
110Serotonergic synapse_Homo sapiens_hsa047260.42846203
111Purine metabolism_Homo sapiens_hsa002300.42524198
112Phototransduction_Homo sapiens_hsa047440.42404422
113Tryptophan metabolism_Homo sapiens_hsa003800.42259735
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42123266
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40904498
116Pancreatic secretion_Homo sapiens_hsa049720.38116878
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38034407
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.37296031
119Autoimmune thyroid disease_Homo sapiens_hsa053200.37288181
120Leishmaniasis_Homo sapiens_hsa051400.35401388
121Renin secretion_Homo sapiens_hsa049240.34952209
122Nicotine addiction_Homo sapiens_hsa050330.34759725
123Arachidonic acid metabolism_Homo sapiens_hsa005900.34723017
124RNA transport_Homo sapiens_hsa030130.33864171
125Herpes simplex infection_Homo sapiens_hsa051680.33846180
126Phagosome_Homo sapiens_hsa041450.33488046
127Linoleic acid metabolism_Homo sapiens_hsa005910.32782667
128Asthma_Homo sapiens_hsa053100.32713692
129Insulin resistance_Homo sapiens_hsa049310.32015026
130Toxoplasmosis_Homo sapiens_hsa051450.31910494
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30652959

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