PYGB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.02247758
2negative regulation of potassium ion transmembrane transport (GO:1901380)5.85398116
3cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.65819860
4regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.53264758
5negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.49384215
6cell communication by electrical coupling (GO:0010644)5.34268902
7cardiac myofibril assembly (GO:0055003)5.33732403
8regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.22922690
9sarcomere organization (GO:0045214)5.20078257
10regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.09408478
11desmosome organization (GO:0002934)5.08369395
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.99387437
13regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.87872562
14cell communication involved in cardiac conduction (GO:0086065)4.87343083
15plasma membrane repair (GO:0001778)4.84475227
16protein localization to endosome (GO:0036010)4.73814750
17cardiac muscle contraction (GO:0060048)4.73691587
18COPI coating of Golgi vesicle (GO:0048205)4.73406974
19Golgi transport vesicle coating (GO:0048200)4.73406974
20regulation of membrane repolarization (GO:0060306)4.43135692
21ventricular cardiac muscle cell action potential (GO:0086005)4.38499305
22tricarboxylic acid cycle (GO:0006099)4.37272195
23myofibril assembly (GO:0030239)4.33959074
24cell-substrate junction assembly (GO:0007044)4.32188040
25regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.24666060
26sodium ion export (GO:0071436)4.12471075
27regulation of actin filament-based movement (GO:1903115)4.11873842
28regulation of relaxation of muscle (GO:1901077)3.95911388
29barbed-end actin filament capping (GO:0051016)3.90976011
30epithelial cell-cell adhesion (GO:0090136)3.89942855
31protein retention in ER lumen (GO:0006621)3.89430676
32semaphorin-plexin signaling pathway (GO:0071526)3.89309620
33positive regulation of potassium ion transmembrane transport (GO:1901381)3.87018140
34maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.79251800
35regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.72675996
36activation of Rac GTPase activity (GO:0032863)3.69547538
37adherens junction assembly (GO:0034333)3.67045936
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.63505718
39potassium ion import (GO:0010107)3.61637863
40membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.61105760
41retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.60886476
42cardiac muscle cell development (GO:0055013)3.60627189
43regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.58925737
44positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.57467694
45membrane repolarization (GO:0086009)3.56936327
46cardiac muscle hypertrophy (GO:0003300)3.56442072
47regulation of the force of heart contraction (GO:0002026)3.54034080
48carnitine shuttle (GO:0006853)3.53308227
49actomyosin structure organization (GO:0031032)3.51346989
50bundle of His cell to Purkinje myocyte communication (GO:0086069)3.50390847
51regulation of cell communication by electrical coupling (GO:0010649)3.49181923
52positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.47339381
53cardiac muscle cell action potential involved in contraction (GO:0086002)3.46219999
54cell-substrate adherens junction assembly (GO:0007045)3.45773716
55focal adhesion assembly (GO:0048041)3.45773716
56regulation of synapse structural plasticity (GO:0051823)3.44794533
57regulation of cardiac muscle cell contraction (GO:0086004)3.43619190
58cardiac muscle cell action potential (GO:0086001)3.43311226
59relaxation of cardiac muscle (GO:0055119)3.42464983
60negative regulation of potassium ion transport (GO:0043267)3.40260919
61striated muscle hypertrophy (GO:0014897)3.39525503
62cardiac cell development (GO:0055006)3.39317608
63potassium ion export (GO:0071435)3.34106112
64cardiac conduction (GO:0061337)3.32787534
65synaptic vesicle docking involved in exocytosis (GO:0016081)3.31031998
66basement membrane organization (GO:0071711)3.30759437
67striated muscle contraction (GO:0006941)3.30405291
68regulation of striated muscle contraction (GO:0006942)3.30143770
69cellular potassium ion homeostasis (GO:0030007)3.30006956
70activation of protein kinase A activity (GO:0034199)3.29228848
71regulation of heart rate by cardiac conduction (GO:0086091)3.28448810
72negative regulation of cytosolic calcium ion concentration (GO:0051481)3.27292149
73regulation of acyl-CoA biosynthetic process (GO:0050812)3.26148587
74adult heart development (GO:0007512)3.25193780
75skin morphogenesis (GO:0043589)3.25181237
76regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.23787057
77stress fiber assembly (GO:0043149)3.23013233
78membrane repolarization during action potential (GO:0086011)3.22792595
79heart trabecula formation (GO:0060347)3.19960697
80ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.19199569
81dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.18013020
82regulation of calcium ion transmembrane transport (GO:1903169)3.17145349
83regulation of calcium ion transmembrane transporter activity (GO:1901019)3.17145349
84negative regulation of catenin import into nucleus (GO:0035414)3.17095320
85regulation of early endosome to late endosome transport (GO:2000641)3.14927047
86regulation of cardiac muscle contraction (GO:0055117)3.13823949
87cell adhesion mediated by integrin (GO:0033627)3.13705501
88regulation of potassium ion transmembrane transport (GO:1901379)3.12694158
89synaptic vesicle maturation (GO:0016188)3.12043521
90regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.11216789
91muscle filament sliding (GO:0030049)3.09817042
92actin-myosin filament sliding (GO:0033275)3.09817042
93endothelial cell chemotaxis (GO:0035767)3.09501338
94apoptotic process involved in morphogenesis (GO:0060561)3.08902251
95cardiac muscle tissue morphogenesis (GO:0055008)3.06531411
96regulation of heart rate (GO:0002027)3.05723113
97regulation of coenzyme metabolic process (GO:0051196)3.04933520
98regulation of cofactor metabolic process (GO:0051193)3.04933520
99fatty acid transmembrane transport (GO:1902001)3.01387405
100positive regulation of potassium ion transport (GO:0043268)3.00273398
101negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.99867017
102actin filament depolymerization (GO:0030042)2.99368020
103planar cell polarity pathway involved in neural tube closure (GO:0090179)2.96024062
104positive regulation of sodium ion transport (GO:0010765)2.93570450
105regulation of heart contraction (GO:0008016)2.90620653
106regulation of potassium ion transmembrane transporter activity (GO:1901016)2.90589955
107protein targeting to plasma membrane (GO:0072661)2.90406809
108negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.90245943
109negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.88774561
110muscle hypertrophy (GO:0014896)2.88278170
111locomotory exploration behavior (GO:0035641)2.86711229
112protein maturation by protein folding (GO:0022417)2.86567325
113cardiac muscle adaptation (GO:0014887)2.86488426
114cardiac muscle hypertrophy in response to stress (GO:0014898)2.86488426
115muscle hypertrophy in response to stress (GO:0003299)2.86488426
116sarcoplasmic reticulum calcium ion transport (GO:0070296)2.85837819
117positive regulation of receptor recycling (GO:0001921)2.85804894
118cell volume homeostasis (GO:0006884)2.85126972
119regulation of sarcomere organization (GO:0060297)2.83679700
120proline transport (GO:0015824)2.83319820
121positive regulation of cation channel activity (GO:2001259)2.82620695
122cellular sodium ion homeostasis (GO:0006883)2.82572536
123cytoskeletal anchoring at plasma membrane (GO:0007016)2.81873442
124layer formation in cerebral cortex (GO:0021819)2.81453322
125potassium ion homeostasis (GO:0055075)2.81271054
126negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.76856661
127cellular copper ion homeostasis (GO:0006878)2.75030673
128endodermal cell differentiation (GO:0035987)2.74849383
129endothelial cell morphogenesis (GO:0001886)2.73125215
130muscle tissue morphogenesis (GO:0060415)2.72195365
131alanine transport (GO:0032328)2.72169700
132regulation of cholesterol homeostasis (GO:2000188)2.70063000
133regulation of skeletal muscle contraction (GO:0014819)2.69919191
134regulation of cation channel activity (GO:2001257)2.69267996
135establishment of nucleus localization (GO:0040023)2.69198925
136NADH metabolic process (GO:0006734)2.68240426
137positive regulation of pseudopodium assembly (GO:0031274)2.68234178
138regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.68061227
139negative regulation of cell size (GO:0045792)2.67939928
140growth hormone secretion (GO:0030252)2.67897770
141positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.67814493
142mesodermal cell differentiation (GO:0048333)2.67495947
143regulation of tight junction assembly (GO:2000810)2.65534646
144regulation of fatty acid oxidation (GO:0046320)2.65450547
145L-serine transport (GO:0015825)2.64509790
146cell-cell junction maintenance (GO:0045217)2.63592970
147hypotonic response (GO:0006971)2.63495082
148regulation of short-term neuronal synaptic plasticity (GO:0048172)2.63405397
149regulation of cardioblast differentiation (GO:0051890)2.62643631
150peptidyl-proline hydroxylation (GO:0019511)2.61583981
151endocytic recycling (GO:0032456)2.61112355
152G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.60301757
153negative regulation of chondrocyte differentiation (GO:0032331)2.59771539
154endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.56886607
155actin filament bundle organization (GO:0061572)2.56191567
156actin filament bundle assembly (GO:0051017)2.56191567
157regulation of glucose import in response to insulin stimulus (GO:2001273)2.55640634
158positive regulation of protein localization to plasma membrane (GO:1903078)2.55498407
159regulation of cholesterol biosynthetic process (GO:0045540)2.53786253
160muscle cell migration (GO:0014812)2.53624764
161branching involved in mammary gland duct morphogenesis (GO:0060444)2.53176036
162protein hydroxylation (GO:0018126)2.53102240
163retina vasculature morphogenesis in camera-type eye (GO:0061299)2.47639656
164negative regulation of anoikis (GO:2000811)2.47252492
165glucose catabolic process (GO:0006007)2.47077317
166regulation of mammary gland epithelial cell proliferation (GO:0033599)2.45759097
167glucose 6-phosphate metabolic process (GO:0051156)2.43785527
168glutamate secretion (GO:0014047)2.43201606
169vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.42768138
170negative regulation of homotypic cell-cell adhesion (GO:0034111)2.42530301
171cell junction assembly (GO:0034329)2.41746865
172substrate-dependent cell migration (GO:0006929)2.39733449
173adherens junction organization (GO:0034332)2.37220860
174positive regulation of osteoblast proliferation (GO:0033690)2.37013225
175cell junction maintenance (GO:0034331)2.36815812
176atrioventricular valve morphogenesis (GO:0003181)2.36630316
177myelin maintenance (GO:0043217)2.35344125
178activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.35115253
179proline biosynthetic process (GO:0006561)2.33235601
180vesicle coating (GO:0006901)2.31549861
181regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.31451698
182regulation of pseudopodium assembly (GO:0031272)2.29892061
183regulation of anoikis (GO:2000209)2.29147292
184regulation of extracellular matrix disassembly (GO:0010715)2.28601449
185cell junction organization (GO:0034330)2.28008106
186signal complex assembly (GO:0007172)2.27109550
187gap junction assembly (GO:0016264)2.26834976
188pentose-phosphate shunt (GO:0006098)2.26739935
189positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.26238918
190mitotic nuclear envelope reassembly (GO:0007084)2.26147890
191nuclear envelope reassembly (GO:0031468)2.26147890
192membrane protein ectodomain proteolysis (GO:0006509)2.26143122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.73357772
2EZH2_22144423_ChIP-Seq_EOC_Human3.69456980
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.62981741
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.88854607
5EP300_21415370_ChIP-Seq_HL-1_Mouse2.60189157
6ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.52033083
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.39580356
8DROSHA_22980978_ChIP-Seq_HELA_Human2.34314375
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16998273
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16998273
11ZNF263_19887448_ChIP-Seq_K562_Human2.14590482
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.11885610
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.10042007
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.09875410
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00663317
16* TBX20_22080862_ChIP-Seq_HEART_Mouse2.00408339
17* TBX20_22328084_ChIP-Seq_HEART_Mouse2.00408339
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95097331
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93760857
20* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.93259882
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.92880843
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.91684449
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86044041
24RARB_27405468_Chip-Seq_BRAIN_Mouse1.83614530
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.81684065
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80981510
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.78958977
28KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.77776756
29* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.77149383
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76627794
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.75877891
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73971826
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.73814120
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73795292
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72737256
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.70240963
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68097668
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66522323
39* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65506329
40KDM2B_26808549_Chip-Seq_K562_Human1.64852737
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.63480755
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62328112
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.61905737
44ATF3_27146783_Chip-Seq_COLON_Human1.61485954
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60959784
46KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.60870821
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.57522082
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.57217830
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.56196993
50EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.54081100
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52694406
52CLOCK_20551151_ChIP-Seq_293T_Human1.50331806
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50225282
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47579582
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.45282044
56SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43938951
57TCF7_22412390_ChIP-Seq_EML_Mouse1.43694618
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42797883
59TP53_22127205_ChIP-Seq_IMR90_Human1.41758301
60TRIM28_21343339_ChIP-Seq_HEK293_Human1.41008771
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.40909422
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40465751
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40062871
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38866554
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.38260087
66WT1_25993318_ChIP-Seq_PODOCYTE_Human1.38243426
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.38168626
68* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.37628865
69SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36800149
70SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36800149
71KDM2B_26808549_Chip-Seq_DND41_Human1.36373382
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35385233
73LXR_22292898_ChIP-Seq_THP-1_Human1.34120328
74UBF1/2_26484160_Chip-Seq_HMECs_Human1.33354739
75NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31710835
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30191381
77DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30068524
78REST_18959480_ChIP-ChIP_MESCs_Mouse1.28942894
79CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24979685
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23156306
81REST_21632747_ChIP-Seq_MESCs_Mouse1.22740044
82VDR_21846776_ChIP-Seq_THP-1_Human1.22539605
83ERG_21242973_ChIP-ChIP_JURKAT_Human1.21647996
84* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21634200
85P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20539213
86ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19324668
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19322799
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16352617
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.16219041
90* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15146215
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14259005
92P68_20966046_ChIP-Seq_HELA_Human1.13562406
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13085624
94CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12860103
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12109223
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11155567
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10849142
98* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09310497
99SOX2_21211035_ChIP-Seq_LN229_Gbm1.08875983
100IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08583183
101ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08494479
102MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.08014430
103* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.07779057
104SA1_27219007_Chip-Seq_ERYTHROID_Human1.07498820
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07229661
106AHR_22903824_ChIP-Seq_MCF-7_Human1.06844185
107CTCF_27219007_Chip-Seq_Bcells_Human1.06272167
108CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05752189
109GATA2_21666600_ChIP-Seq_HMVEC_Human1.05256814
110P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04757413
111AR_19668381_ChIP-Seq_PC3_Human1.04473330
112KDM2B_26808549_Chip-Seq_JURKAT_Human1.03933183
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03699119
114CDX2_20551321_ChIP-Seq_CACO-2_Human1.02942961
115PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01780439
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00062752
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99895243
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99758604
119RACK7_27058665_Chip-Seq_MCF-7_Human0.99493811
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.98949319
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98858467
122ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98416347
123ZNF274_21170338_ChIP-Seq_K562_Hela0.98122845
124MYC_22102868_ChIP-Seq_BL_Human0.97422042
125CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97293899
126NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97276136
127TET1_21490601_ChIP-Seq_MESCs_Mouse0.96208660
128* RUNX1_27514584_Chip-Seq_MCF-7_Human0.95835665
129ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.95727861
130CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94996893
131SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.94580714
132TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.94571656
133CREB1_26743006_Chip-Seq_LNCaP_Human0.94437104
134ISL1_27105846_Chip-Seq_CPCs_Mouse0.94211568
135EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.94196000
136TP63_22573176_ChIP-Seq_HFKS_Human0.94070379
137ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93712284
138SMC4_20622854_ChIP-Seq_HELA_Human0.93630622
139SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92604980
140ELK3_25401928_ChIP-Seq_HUVEC_Human0.91558730
141RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90960438
142ARNT_22903824_ChIP-Seq_MCF-7_Human0.90514602
143SMAD3_21741376_ChIP-Seq_HESCs_Human0.90387560
144PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89633012
145TP53_20018659_ChIP-ChIP_R1E_Mouse0.87941499
146TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87436629
147* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87432129
148* AR_21572438_ChIP-Seq_LNCaP_Human0.86881982
149TP53_23651856_ChIP-Seq_MEFs_Mouse0.86335287
150GBX2_23144817_ChIP-Seq_PC3_Human0.85548480
151* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.85085523

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.57916074
2MP0004084_abnormal_cardiac_muscle4.56986206
3MP0000751_myopathy4.46147765
4MP0004215_abnormal_myocardial_fiber4.00052958
5MP0003646_muscle_fatigue3.94384916
6MP0004036_abnormal_muscle_relaxation3.26130281
7MP0004130_abnormal_muscle_cell2.87462865
8MP0005330_cardiomyopathy2.87317027
9MP0004859_abnormal_synaptic_plasticity2.87174078
10MP0002877_abnormal_melanocyte_morpholog2.80499954
11MP0002972_abnormal_cardiac_muscle2.64222885
12MP0005257_abnormal_intraocular_pressure2.57975535
13MP0001849_ear_inflammation2.54042409
14MP0003137_abnormal_impulse_conducting2.53419251
15MP0004858_abnormal_nervous_system2.49414934
16MP0000749_muscle_degeneration2.44824369
17MP0008775_abnormal_heart_ventricle2.43317625
18MP0004087_abnormal_muscle_fiber2.42824649
19MP0000537_abnormal_urethra_morphology2.39365230
20MP0005409_darkened_coat_color2.27715751
21MP0005620_abnormal_muscle_contractility2.14564763
22MP0005385_cardiovascular_system_phenoty2.13614213
23MP0001544_abnormal_cardiovascular_syste2.13614213
24MP0000579_abnormal_nail_morphology2.08860239
25MP0006138_congestive_heart_failure2.07004258
26MP0004484_altered_response_of2.05769185
27MP0003453_abnormal_keratinocyte_physiol2.02977999
28MP0010630_abnormal_cardiac_muscle1.98712610
29MP0002060_abnormal_skin_morphology1.95754063
30MP0000750_abnormal_muscle_regeneration1.95051984
31MP0003191_abnormal_cellular_cholesterol1.94642569
32MP0004085_abnormal_heartbeat1.93578403
33MP0009840_abnormal_foam_cell1.89539104
34MP0002909_abnormal_adrenal_gland1.88520717
35MP0008260_abnormal_autophagy1.86741846
36MP0005023_abnormal_wound_healing1.80169423
37MP0005058_abnormal_lysosome_morphology1.70464182
38MP0009780_abnormal_chondrocyte_physiolo1.69623493
39MP0005670_abnormal_white_adipose1.69384411
40MP0005666_abnormal_adipose_tissue1.69155486
41MP0005451_abnormal_body_composition1.66451084
42MP0002796_impaired_skin_barrier1.65508731
43MP0002106_abnormal_muscle_physiology1.65467177
44MP0004233_abnormal_muscle_weight1.64206441
45MP0002269_muscular_atrophy1.63988764
46MP0000762_abnormal_tongue_morphology1.62168785
47MP0002089_abnormal_postnatal_growth/wei1.58902432
48MP0003329_amyloid_beta_deposits1.57658847
49MP0010030_abnormal_orbit_morphology1.57552293
50MP0000566_synostosis1.56636675
51MP0000747_muscle_weakness1.54584948
52MP0003635_abnormal_synaptic_transmissio1.54542273
53MP0000467_abnormal_esophagus_morphology1.53103628
54MP0005623_abnormal_meninges_morphology1.52972521
55MP0005076_abnormal_cell_differentiation1.51434610
56MP0003705_abnormal_hypodermis_morpholog1.49318227
57MP0005171_absent_coat_pigmentation1.48891477
58MP0005501_abnormal_skin_physiology1.47193397
59MP0003828_pulmonary_edema1.45332972
60MP0003279_aneurysm1.44957600
61MP0004510_myositis1.44053775
62MP0000759_abnormal_skeletal_muscle1.43648867
63MP0002735_abnormal_chemical_nociception1.38681974
64MP0005369_muscle_phenotype1.35681362
65MP0004270_analgesia1.33644941
66MP0004145_abnormal_muscle_electrophysio1.32806123
67MP0000013_abnormal_adipose_tissue1.32549382
68MP0004185_abnormal_adipocyte_glucose1.27859438
69MP0005375_adipose_tissue_phenotype1.25505974
70MP0003221_abnormal_cardiomyocyte_apopto1.24851797
71MP0002896_abnormal_bone_mineralization1.24776424
72MP0000733_abnormal_muscle_development1.22235382
73MP0001968_abnormal_touch/_nociception1.21483267
74MP0008569_lethality_at_weaning1.20037174
75MP0000534_abnormal_ureter_morphology1.18576023
76MP0002127_abnormal_cardiovascular_syste1.17288562
77MP0001348_abnormal_lacrimal_gland1.15886944
78MP0000462_abnormal_digestive_system1.13638470
79MP0008438_abnormal_cutaneous_collagen1.13272910
80MP0003123_paternal_imprinting1.12809899
81MP0010368_abnormal_lymphatic_system1.10262384
82MP0002063_abnormal_learning/memory/cond1.08317369
83MP0002733_abnormal_thermal_nociception1.06656442
84MP0001216_abnormal_epidermal_layer1.06525229
85MP0010771_integument_phenotype1.05578606
86MP0010352_gastrointestinal_tract_polyps1.04339781
87MP0003690_abnormal_glial_cell1.03207057
88MP0002064_seizures1.01109284
89MP0002736_abnormal_nociception_after1.00128074
90MP0003566_abnormal_cell_adhesion0.99715836
91MP0009053_abnormal_anal_canal0.99506334
92MP0009745_abnormal_behavioral_response0.99452904
93MP0000858_altered_metastatic_potential0.99396782
94MP0009046_muscle_twitch0.99370255
95MP0005165_increased_susceptibility_to0.98396359
96MP0001970_abnormal_pain_threshold0.97366537
97MP0000003_abnormal_adipose_tissue0.96319128
98MP0002734_abnormal_mechanical_nocicepti0.94496038
99MP0003045_fibrosis0.93564216
100MP0008961_abnormal_basal_metabolism0.93540534
101MP0000767_abnormal_smooth_muscle0.92098779
102MP0005167_abnormal_blood-brain_barrier0.90196585
103MP0002098_abnormal_vibrissa_morphology0.89094226
104MP0005621_abnormal_cell_physiology0.88226682
105MP0003633_abnormal_nervous_system0.87857317
106MP0004924_abnormal_behavior0.87458053
107MP0005386_behavior/neurological_phenoty0.87458053
108MP0002272_abnormal_nervous_system0.87346152
109MP0002822_catalepsy0.87336141
110MP0000266_abnormal_heart_morphology0.87311442
111MP0004272_abnormal_basement_membrane0.85971358
112MP0002332_abnormal_exercise_endurance0.85654277
113MP0001915_intracranial_hemorrhage0.83732598
114MP0001958_emphysema0.82723583
115MP0005595_abnormal_vascular_smooth0.82411446
116MP0005508_abnormal_skeleton_morphology0.81931819
117MP0002234_abnormal_pharynx_morphology0.81741281
118MP0003880_abnormal_central_pattern0.81507678
119MP0000343_altered_response_to0.80781133
120MP0004264_abnormal_extraembryonic_tissu0.80723642
121MP0003634_abnormal_glial_cell0.79259237
122MP0001486_abnormal_startle_reflex0.77802168
123MP0004811_abnormal_neuron_physiology0.77078366
124MP0003950_abnormal_plasma_membrane0.76967773
125MP0001299_abnormal_eye_distance/0.75888463
126MP0005275_abnormal_skin_tensile0.74596342
127MP0000920_abnormal_myelination0.74481213
128MP0000678_abnormal_parathyroid_gland0.73626208
129MP0002249_abnormal_larynx_morphology0.73220126
130MP0002572_abnormal_emotion/affect_behav0.72901773
131MP0002067_abnormal_sensory_capabilities0.72667912
132MP0001440_abnormal_grooming_behavior0.71708955
133MP0000604_amyloidosis0.71209574
134MP0000230_abnormal_systemic_arterial0.69972757
135MP0006036_abnormal_mitochondrial_physio0.69786574
136MP0005187_abnormal_penis_morphology0.67694249
137MP0003115_abnormal_respiratory_system0.67440772
138MP0001664_abnormal_digestion0.67217582
139MP0002128_abnormal_blood_circulation0.67178508
140MP0002108_abnormal_muscle_morphology0.66765815
141MP0000377_abnormal_hair_follicle0.66230064
142MP0003385_abnormal_body_wall0.65418585
143MP0009384_cardiac_valve_regurgitation0.65066820
144MP0003075_altered_response_to0.64051728
145MP0004947_skin_inflammation0.62869571
146MP0001614_abnormal_blood_vessel0.62313846
147MP0003631_nervous_system_phenotype0.61435991
148MP0010678_abnormal_skin_adnexa0.61229721
149MP0005197_abnormal_uvea_morphology0.60976139
150MP0000955_abnormal_spinal_cord0.60618752
151MP0003879_abnormal_hair_cell0.59570738
152MP0003172_abnormal_lysosome_physiology0.59327250
153MP0005535_abnormal_body_temperature0.58205480
154MP0002184_abnormal_innervation0.56831068
155MP0010234_abnormal_vibrissa_follicle0.54695170
156MP0003091_abnormal_cell_migration0.54568576

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.51402480
2Atrial fibrillation (HP:0005110)5.05253943
3Ventricular tachycardia (HP:0004756)5.04942927
4Primary atrial arrhythmia (HP:0001692)4.81284509
5Bundle branch block (HP:0011710)4.67110612
6Supraventricular tachycardia (HP:0004755)4.60045412
7Supraventricular arrhythmia (HP:0005115)4.54282498
8Premature rupture of membranes (HP:0001788)4.23288376
9Ventricular fibrillation (HP:0001663)4.23272471
10Syncope (HP:0001279)4.20145633
11Hyporeflexia of lower limbs (HP:0002600)4.13257917
12Right ventricular cardiomyopathy (HP:0011663)4.11075833
13Exercise-induced myalgia (HP:0003738)4.09421437
14Calf muscle hypertrophy (HP:0008981)4.08911078
15Prolonged QT interval (HP:0001657)3.99360478
16Lipoatrophy (HP:0100578)3.95794251
17Exercise-induced muscle cramps (HP:0003710)3.92529660
18Abnormality of the calf musculature (HP:0001430)3.87827957
19Distal upper limb amyotrophy (HP:0007149)3.87494812
20Upper limb amyotrophy (HP:0009129)3.87494812
21Muscle fiber splitting (HP:0003555)3.82614251
22Distal lower limb amyotrophy (HP:0008944)3.74223781
23Ventricular arrhythmia (HP:0004308)3.73615760
24Protrusio acetabuli (HP:0003179)3.65785521
25Atrophic scars (HP:0001075)3.61562511
26Myoglobinuria (HP:0002913)3.61399590
27Heart block (HP:0012722)3.60233588
28Atrioventricular block (HP:0001678)3.56364290
29Muscle hypertrophy of the lower extremities (HP:0008968)3.50205178
30Palpitations (HP:0001962)3.43088787
31Asymmetric septal hypertrophy (HP:0001670)3.39922293
32Abnormality of the left ventricular outflow tract (HP:0011103)3.39379748
33Subaortic stenosis (HP:0001682)3.39379748
34Abnormal atrioventricular conduction (HP:0005150)3.37605182
35Difficulty running (HP:0009046)3.25192529
36Hand muscle atrophy (HP:0009130)3.20870501
37Myotonia (HP:0002486)3.19281863
38Abnormal EKG (HP:0003115)3.13765037
39Fragile skin (HP:0001030)3.10635237
40Dilated cardiomyopathy (HP:0001644)3.07586771
41Increased connective tissue (HP:0009025)3.06322368
42Neurofibrillary tangles (HP:0002185)2.99608545
43Myokymia (HP:0002411)2.95442944
44EMG: myopathic abnormalities (HP:0003458)2.94600522
45Broad face (HP:0000283)2.93623975
46Pheochromocytoma (HP:0002666)2.91757737
47Short nail (HP:0001799)2.84591729
48Cerebral inclusion bodies (HP:0100314)2.78802276
49Broad metatarsal (HP:0001783)2.73749701
50Spinal rigidity (HP:0003306)2.67134392
51Increased variability in muscle fiber diameter (HP:0003557)2.64110902
52Achilles tendon contracture (HP:0001771)2.61543403
53Vertebral compression fractures (HP:0002953)2.55591739
54Dysmetric saccades (HP:0000641)2.53218402
55Milia (HP:0001056)2.49670104
56Neuroendocrine neoplasm (HP:0100634)2.49186746
57Difficulty climbing stairs (HP:0003551)2.46094429
58Obstructive sleep apnea (HP:0002870)2.46048128
59Action tremor (HP:0002345)2.44480931
60Arterial tortuosity (HP:0005116)2.43346755
61Cervical subluxation (HP:0003308)2.39064598
62Left ventricular hypertrophy (HP:0001712)2.39048599
63Abnormality of the Achilles tendon (HP:0005109)2.38302943
64Limb-girdle muscle atrophy (HP:0003797)2.36864357
65Ulnar bowing (HP:0003031)2.33365101
66Osteolytic defects of the phalanges of the hand (HP:0009771)2.32214014
67Osteolytic defects of the hand bones (HP:0009699)2.32214014
68Vascular tortuosity (HP:0004948)2.30326371
69Abnormality of the foot musculature (HP:0001436)2.28976618
70Flat acetabular roof (HP:0003180)2.27642748
71Ketoacidosis (HP:0001993)2.27286014
72Foot dorsiflexor weakness (HP:0009027)2.25479325
73Upper limb muscle weakness (HP:0003484)2.24004529
74Megalencephaly (HP:0001355)2.21671106
75Abnormality of the distal phalanges of the toes (HP:0010182)2.19581881
76Cerebral aneurysm (HP:0004944)2.19106389
77Abnormality of skeletal muscle fiber size (HP:0012084)2.16308095
78Wormian bones (HP:0002645)2.16091344
79Lymphangioma (HP:0100764)2.11357197
80Sudden cardiac death (HP:0001645)2.11346670
81Mitral regurgitation (HP:0001653)2.10013283
82Fragile nails (HP:0001808)2.09825706
83Hamartoma of the eye (HP:0010568)2.09401153
84Advanced eruption of teeth (HP:0006288)2.09329915
85Bladder diverticulum (HP:0000015)2.08433357
86Rapidly progressive (HP:0003678)2.07302183
87Natal tooth (HP:0000695)2.05283848
88Spinal cord compression (HP:0002176)2.03501655
89Generalized amyotrophy (HP:0003700)2.02955047
90Abnormality of carpal bone ossification (HP:0006257)2.02492264
91Rhabdomyolysis (HP:0003201)2.01342028
92Athetosis (HP:0002305)2.01098707
93Scapular winging (HP:0003691)1.99943092
94Muscle stiffness (HP:0003552)1.98168901
95Abnormal ossification of hand bones (HP:0005921)1.97251664
96Axonal loss (HP:0003447)1.96284965
97Supranuclear gaze palsy (HP:0000605)1.95686672
98Centrally nucleated skeletal muscle fibers (HP:0003687)1.95668192
99Neoplasm of the peripheral nervous system (HP:0100007)1.94698381
100Nail dystrophy (HP:0008404)1.94621428
101Ankyloglossia (HP:0010296)1.94219246
102Hypercortisolism (HP:0001578)1.93418429
103Bradycardia (HP:0001662)1.93274294
104Mildly elevated creatine phosphokinase (HP:0008180)1.92764799
105J-shaped sella turcica (HP:0002680)1.90623816
106Aortic dissection (HP:0002647)1.89393021
107Depression (HP:0000716)1.89360554
108Lower limb amyotrophy (HP:0007210)1.88510346
109Elbow flexion contracture (HP:0002987)1.87429548
110Back pain (HP:0003418)1.87409731
111Visual hallucinations (HP:0002367)1.86708203
112Insidious onset (HP:0003587)1.86596227
113Termporal pattern (HP:0011008)1.86596227
114Facial diplegia (HP:0001349)1.85028409
115Distal sensory impairment (HP:0002936)1.83740416
116Reduced subcutaneous adipose tissue (HP:0003758)1.83524630
117Mesangial abnormality (HP:0001966)1.82697586
118Pterygium (HP:0001059)1.82077456
119Neonatal short-limb short stature (HP:0008921)1.79780577
120Conjunctival hamartoma (HP:0100780)1.79639079
121Hemorrhage of the eye (HP:0011885)1.79630822
122Abnormality of oral frenula (HP:0000190)1.79511245
123Hemiplegia (HP:0002301)1.79496594
124Hyperacusis (HP:0010780)1.78710108
125Onycholysis (HP:0001806)1.77581185
126Long palpebral fissure (HP:0000637)1.77285046
127Focal seizures (HP:0007359)1.77062255
128Abnormality of pain sensation (HP:0010832)1.76657275
129Impaired pain sensation (HP:0007328)1.76657275
130Abnormality of the vocal cords (HP:0008777)1.76061231
131Alopecia of scalp (HP:0002293)1.75222668
132Testicular atrophy (HP:0000029)1.74921418
133EMG: neuropathic changes (HP:0003445)1.74214235
134Aneurysm (HP:0002617)1.73235282
135Neoplasm of the adrenal gland (HP:0100631)1.72950005
136Abnormality of the distal phalanx of the thumb (HP:0009617)1.72860279
137Aortic aneurysm (HP:0004942)1.72492693
138Ankle contracture (HP:0006466)1.72262255
139Congestive heart failure (HP:0001635)1.71954876
140Acanthosis nigricans (HP:0000956)1.71877132
141Nuclear cataract (HP:0100018)1.70716742
142Urinary urgency (HP:0000012)1.70242730
143Trismus (HP:0000211)1.70113455
144Insomnia (HP:0100785)1.69957164
145Blue sclerae (HP:0000592)1.69822168
146Palmoplantar keratoderma (HP:0000982)1.69604571
147Ankle clonus (HP:0011448)1.69450738
148Hammertoe (HP:0001765)1.68967167
149Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.68888026
150Ulnar claw (HP:0001178)1.67529651
151Aplasia involving bones of the extremities (HP:0009825)1.67260065
152Aplasia involving bones of the upper limbs (HP:0009823)1.67260065
153Aplasia of the phalanges of the hand (HP:0009802)1.67260065
154Focal motor seizures (HP:0011153)1.66882189
155Hypoventilation (HP:0002791)1.66830223
156Vertebral arch anomaly (HP:0008438)1.66623003
157Onion bulb formation (HP:0003383)1.66447538
158Disproportionate tall stature (HP:0001519)1.66308877
159Distal lower limb muscle weakness (HP:0009053)1.65981237
160Glucose intolerance (HP:0000833)1.65938895
161Stridor (HP:0010307)1.64986605
162Decreased motor nerve conduction velocity (HP:0003431)1.64941113
163Bronchomalacia (HP:0002780)1.64701604
164Shallow orbits (HP:0000586)1.64098531
165Plantar hyperkeratosis (HP:0007556)1.63722274
166Large for gestational age (HP:0001520)1.62311273
167Enlarged penis (HP:0000040)1.59806206
168Proximal amyotrophy (HP:0007126)1.59664833
169Central scotoma (HP:0000603)1.59226311
170Postural instability (HP:0002172)1.58628841
171Hypoplasia of the iris (HP:0007676)1.58108289
172Ridged nail (HP:0001807)1.57228395
173Coxa vara (HP:0002812)1.56492672
174Abnormality of dentin (HP:0010299)1.54818062
175Hyperparathyroidism (HP:0000843)1.54595592
176Peripheral hypomyelination (HP:0007182)1.54416999

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.43836458
2MST1R4.35169893
3TRIB34.15576139
4TTN3.92888435
5PKN23.14028190
6MET2.75598354
7PDK32.74401205
8PDK42.74401205
9MYLK2.48406043
10IRAK32.48021570
11DMPK2.44754268
12TESK12.26573908
13PRKD32.26197405
14PRPF4B2.25746016
15PAK42.22556585
16NEK12.21281293
17MAP3K92.10714060
18PTK22.08677564
19SMG12.05745781
20ERN12.01580146
21KSR21.98316817
22RIPK11.90614072
23NTRK31.87108947
24NME21.85081625
25ARAF1.77406088
26MINK11.70955694
27* PHKG11.67172042
28* PHKG21.67172042
29PAK31.66613240
30PAK61.63164441
31LATS21.59997105
32PDK21.55547609
33PDGFRA1.53760724
34EPHA41.50629890
35STK381.46038686
36SIK11.43946880
37MAP3K41.38754134
38PINK11.34080231
39RET1.33700359
40CAMKK11.31163254
41PIK3CA1.27832178
42CDC42BPA1.27755716
43NTRK11.22941626
44ROCK11.20688151
45NTRK21.20418243
46BCKDK1.17934608
47PRKD11.15417386
48TESK21.15021762
49MARK11.09678739
50PRKCH1.09304365
51OBSCN1.08895706
52FER1.04164039
53ILK1.03848989
54WNK11.03296139
55MAP3K21.02052249
56ERBB41.01157895
57MAP3K30.99129148
58MAP3K70.96567173
59FGFR40.96273051
60MOS0.96238575
61PRKD20.95129804
62TAOK20.94457853
63SGK30.92596689
64ROCK20.92202125
65CAMK1D0.92135663
66MTOR0.90422753
67MAPKAPK30.89716959
68EEF2K0.89494566
69CAMK2D0.87865319
70CAMK1G0.87240649
71STK240.82527844
72CDK120.82153897
73TYRO30.82028390
74DAPK20.81293194
75TIE10.80962785
76MAP2K40.80474271
77CDK50.79100027
78PDPK10.76958284
79CAMK10.75678773
80TAOK10.75344583
81PDK10.74325970
82PIM20.73486653
83MUSK0.73290282
84LRRK20.73261083
85SCYL20.72667031
86MAPK120.72496276
87MAP3K60.72408726
88PTK2B0.71419198
89DDR20.70892739
90PTK60.69408415
91DAPK30.68825123
92PRKAA10.68786955
93CAMK40.68181769
94PAK20.66761094
95MAP2K10.65847331
96LIMK10.64142722
97KSR10.63641740
98SGK20.62725392
99SGK4940.62669344
100SGK2230.62669344
101CAMK2A0.62593665
102RPS6KA20.61982216
103ALK0.61377625
104WNK40.59109514
105BRAF0.58262209
106EPHB20.57175499
107CAMK2G0.56563501
108ICK0.54370755
109IRAK20.54167879
110FGFR30.53846599
111CAMK2B0.52574172
112CDK150.51490619
113CDK180.50082088
114PRKCE0.49699816
115CDK11A0.48233699
116PDGFRB0.47417065
117MAP3K10.47067506
118JAK10.46857559
119STK390.46424437
120GRK70.46401690
121FGFR20.45632802
122MAPK110.45313876
123PRKACG0.45150132
124CAMKK20.43893782
125CDK140.43885987
126STK110.43875676
127EPHB10.42654378
128MARK20.42381008
129PRKG20.41626305
130MAP3K130.41167929
131ABL20.40944466
132PRKAA20.40787151
133PAK10.40005093
134UHMK10.39759947
135RPS6KA30.38741372
136BMX0.38439616
137DAPK10.38126842
138MAP3K100.37143109
139MAP3K110.36916362
140CDK80.35174664
141SRC0.33477598
142BRSK10.32193638
143SIK30.31035804
144GSK3A0.29969874
145MAP3K80.29698471
146PRKCI0.29377554
147PBK0.29015116
148FLT30.26647110
149AKT20.24925838

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.92041016
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.83392144
3Dilated cardiomyopathy_Homo sapiens_hsa054142.65055764
4Cardiac muscle contraction_Homo sapiens_hsa042602.46287785
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.28493593
6Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.07631375
7Propanoate metabolism_Homo sapiens_hsa006401.97307780
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94524839
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88635649
10Fatty acid degradation_Homo sapiens_hsa000711.80059913
11Fatty acid metabolism_Homo sapiens_hsa012121.79519309
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.78465552
13Fatty acid biosynthesis_Homo sapiens_hsa000611.74521812
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.60489479
15Nitrogen metabolism_Homo sapiens_hsa009101.53307835
16Gastric acid secretion_Homo sapiens_hsa049711.52898941
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.51947125
18Vibrio cholerae infection_Homo sapiens_hsa051101.49058021
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44432987
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.42560531
21Carbon metabolism_Homo sapiens_hsa012001.41092491
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40437946
23Pentose phosphate pathway_Homo sapiens_hsa000301.39922965
24Circadian entrainment_Homo sapiens_hsa047131.37853424
25Olfactory transduction_Homo sapiens_hsa047401.36480843
26Fructose and mannose metabolism_Homo sapiens_hsa000511.35756160
27Notch signaling pathway_Homo sapiens_hsa043301.35188509
28Chronic myeloid leukemia_Homo sapiens_hsa052201.34562133
29Prion diseases_Homo sapiens_hsa050201.34032791
30Galactose metabolism_Homo sapiens_hsa000521.30573101
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.27938344
32Other glycan degradation_Homo sapiens_hsa005111.27311487
33Salivary secretion_Homo sapiens_hsa049701.27158311
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.22551952
35Insulin secretion_Homo sapiens_hsa049111.22218415
36Renin secretion_Homo sapiens_hsa049241.22203192
37Synaptic vesicle cycle_Homo sapiens_hsa047211.22069984
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21377576
39Small cell lung cancer_Homo sapiens_hsa052221.20949803
40Long-term potentiation_Homo sapiens_hsa047201.15743880
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15348907
42Oxytocin signaling pathway_Homo sapiens_hsa049211.15200794
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14567394
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.14378558
45Adipocytokine signaling pathway_Homo sapiens_hsa049201.14256941
46Bladder cancer_Homo sapiens_hsa052191.13664844
47Type II diabetes mellitus_Homo sapiens_hsa049301.12263865
48Calcium signaling pathway_Homo sapiens_hsa040201.10623564
49Viral myocarditis_Homo sapiens_hsa054161.06416729
50Cholinergic synapse_Homo sapiens_hsa047251.05013587
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04858951
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04740644
53Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04645563
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03657109
55Vitamin B6 metabolism_Homo sapiens_hsa007501.03084860
56Pyruvate metabolism_Homo sapiens_hsa006201.02960228
57cAMP signaling pathway_Homo sapiens_hsa040241.02647119
58* Insulin signaling pathway_Homo sapiens_hsa049101.02462904
59PPAR signaling pathway_Homo sapiens_hsa033201.01201180
60GABAergic synapse_Homo sapiens_hsa047271.01138119
61Glutamatergic synapse_Homo sapiens_hsa047240.97355838
62Gap junction_Homo sapiens_hsa045400.96830896
63GnRH signaling pathway_Homo sapiens_hsa049120.95963072
64Thyroid cancer_Homo sapiens_hsa052160.95858187
65Hippo signaling pathway_Homo sapiens_hsa043900.93747591
66Dorso-ventral axis formation_Homo sapiens_hsa043200.93641094
67Dopaminergic synapse_Homo sapiens_hsa047280.92147358
68Non-small cell lung cancer_Homo sapiens_hsa052230.91476868
69Focal adhesion_Homo sapiens_hsa045100.91017494
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.90385221
71Pancreatic cancer_Homo sapiens_hsa052120.90310597
72* Glucagon signaling pathway_Homo sapiens_hsa049220.90029525
73Morphine addiction_Homo sapiens_hsa050320.89966700
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88756493
75Estrogen signaling pathway_Homo sapiens_hsa049150.88566570
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.88247865
77* Insulin resistance_Homo sapiens_hsa049310.87086570
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.83810910
79Parkinsons disease_Homo sapiens_hsa050120.83248074
80Glioma_Homo sapiens_hsa052140.82857155
81AMPK signaling pathway_Homo sapiens_hsa041520.82522199
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82017996
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80341838
84Inositol phosphate metabolism_Homo sapiens_hsa005620.79825192
85mTOR signaling pathway_Homo sapiens_hsa041500.78946916
86Amphetamine addiction_Homo sapiens_hsa050310.77479863
87MicroRNAs in cancer_Homo sapiens_hsa052060.75863051
88Butanoate metabolism_Homo sapiens_hsa006500.75454336
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.73401387
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.73030699
91Melanogenesis_Homo sapiens_hsa049160.72797947
92Alzheimers disease_Homo sapiens_hsa050100.70528642
93Sulfur relay system_Homo sapiens_hsa041220.70526153
94Nicotine addiction_Homo sapiens_hsa050330.70338787
95VEGF signaling pathway_Homo sapiens_hsa043700.69709486
96Taste transduction_Homo sapiens_hsa047420.69277438
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68751838
98N-Glycan biosynthesis_Homo sapiens_hsa005100.68309567
99Shigellosis_Homo sapiens_hsa051310.66353590
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65961920
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65899937
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65773110
103Acute myeloid leukemia_Homo sapiens_hsa052210.65323070
104HIF-1 signaling pathway_Homo sapiens_hsa040660.64882025
105Endometrial cancer_Homo sapiens_hsa052130.64525870
106Protein digestion and absorption_Homo sapiens_hsa049740.64164209
107Tight junction_Homo sapiens_hsa045300.64078728
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63203902
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63130634
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61550366
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59155679
112Proteoglycans in cancer_Homo sapiens_hsa052050.59097388
113ECM-receptor interaction_Homo sapiens_hsa045120.58945382
114Pancreatic secretion_Homo sapiens_hsa049720.57951575
115Choline metabolism in cancer_Homo sapiens_hsa052310.57748310
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57412035
117Biosynthesis of amino acids_Homo sapiens_hsa012300.57227501
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56644619
119Pathways in cancer_Homo sapiens_hsa052000.56426422
120Arginine biosynthesis_Homo sapiens_hsa002200.55712788
121Salmonella infection_Homo sapiens_hsa051320.55179135
122Renal cell carcinoma_Homo sapiens_hsa052110.54281478
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54171398
124Axon guidance_Homo sapiens_hsa043600.53449731
125Melanoma_Homo sapiens_hsa052180.53239400
126Lysosome_Homo sapiens_hsa041420.53194401
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52903789
128Rap1 signaling pathway_Homo sapiens_hsa040150.52627438
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52008891
130Cocaine addiction_Homo sapiens_hsa050300.51980408
131Thyroid hormone synthesis_Homo sapiens_hsa049180.51770106
132ErbB signaling pathway_Homo sapiens_hsa040120.51600517
133Amoebiasis_Homo sapiens_hsa051460.51195613
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50539949
135Oxidative phosphorylation_Homo sapiens_hsa001900.50518262
136Basal cell carcinoma_Homo sapiens_hsa052170.50406656
137AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49699629
138Adherens junction_Homo sapiens_hsa045200.46245785
139Endocytosis_Homo sapiens_hsa041440.45973749
140Platelet activation_Homo sapiens_hsa046110.44977805
141Bile secretion_Homo sapiens_hsa049760.44594595
142Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44282656
143Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43378378
144Long-term depression_Homo sapiens_hsa047300.42343982

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