PYCR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* proline biosynthetic process (GO:0006561)7.61763703
2transcription from mitochondrial promoter (GO:0006390)7.11404708
3protein retention in ER lumen (GO:0006621)6.55809473
4replication fork processing (GO:0031297)6.53076908
5embryonic process involved in female pregnancy (GO:0060136)6.40553719
6establishment of apical/basal cell polarity (GO:0035089)6.23446121
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.18246749
8DNA deamination (GO:0045006)5.68795503
9oxidative demethylation (GO:0070989)5.64989245
10positive regulation of protein homooligomerization (GO:0032464)5.53141819
11establishment of monopolar cell polarity (GO:0061162)5.43740797
12establishment or maintenance of monopolar cell polarity (GO:0061339)5.43740797
13* proline metabolic process (GO:0006560)5.38672129
14maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.36438113
15DNA strand renaturation (GO:0000733)5.23394552
16intestinal cholesterol absorption (GO:0030299)5.16878992
17Golgi transport vesicle coating (GO:0048200)5.15748458
18COPI coating of Golgi vesicle (GO:0048205)5.15748458
19regulation of integrin activation (GO:0033623)5.14966352
20L-serine metabolic process (GO:0006563)5.03356156
21GDP-mannose metabolic process (GO:0019673)4.88082991
22somatic hypermutation of immunoglobulin genes (GO:0016446)4.86477710
23somatic diversification of immune receptors via somatic mutation (GO:0002566)4.86477710
24mitochondrial DNA metabolic process (GO:0032042)4.82282480
25regulation of translational fidelity (GO:0006450)4.80425202
26cellular response to ATP (GO:0071318)4.75367488
27DNA unwinding involved in DNA replication (GO:0006268)4.75123272
28poly(A)+ mRNA export from nucleus (GO:0016973)4.74362206
29regulation of protein homooligomerization (GO:0032462)4.65249254
30formation of translation preinitiation complex (GO:0001731)4.51271561
31DNA integration (GO:0015074)4.31027182
32viral mRNA export from host cell nucleus (GO:0046784)4.17316363
33negative regulation of cell cycle arrest (GO:0071157)4.06182498
34mitotic G1 DNA damage checkpoint (GO:0031571)4.02049388
35exocrine pancreas development (GO:0031017)3.98783730
36convergent extension (GO:0060026)3.96953988
37negative regulation of JAK-STAT cascade (GO:0046426)3.96143869
38nuclear pore complex assembly (GO:0051292)3.92930645
39peptidyl-proline hydroxylation (GO:0019511)3.89193579
40positive regulation of developmental pigmentation (GO:0048087)3.86433412
41DNA strand elongation (GO:0022616)3.85028283
42mRNA cleavage (GO:0006379)3.80679416
43peptidyl-arginine omega-N-methylation (GO:0035247)3.79977592
44base-excision repair (GO:0006284)3.79479907
45mitotic chromosome condensation (GO:0007076)3.77208223
46establishment of integrated proviral latency (GO:0075713)3.73411159
47histone H4-K12 acetylation (GO:0043983)3.71175635
48dosage compensation (GO:0007549)3.69869463
49embryonic placenta development (GO:0001892)3.69139808
50telomere maintenance via semi-conservative replication (GO:0032201)3.68637814
51base-excision repair, AP site formation (GO:0006285)3.63570726
52mitotic G1/S transition checkpoint (GO:0044819)3.63270790
53serine family amino acid biosynthetic process (GO:0009070)3.62798881
54embryonic camera-type eye development (GO:0031076)3.62273896
55tRNA aminoacylation for protein translation (GO:0006418)3.60441175
56positive regulation by host of viral transcription (GO:0043923)3.55585757
57G1 DNA damage checkpoint (GO:0044783)3.54633952
58DNA ligation (GO:0006266)3.53178482
59non-recombinational repair (GO:0000726)3.49257611
60double-strand break repair via nonhomologous end joining (GO:0006303)3.49257611
61establishment of protein localization to mitochondrial membrane (GO:0090151)3.49060881
62nucleotide-excision repair, DNA gap filling (GO:0006297)3.47930692
63amino acid activation (GO:0043038)3.45195741
64tRNA aminoacylation (GO:0043039)3.45195741
65negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.43640761
66nuclear pore organization (GO:0006999)3.43290890
67DNA replication initiation (GO:0006270)3.38097391
68face development (GO:0060324)3.34670588
69negative regulation of Ras GTPase activity (GO:0034261)3.34293414
70negative regulation of mRNA processing (GO:0050686)3.33605826
71mitotic sister chromatid segregation (GO:0000070)3.32857194
72spliceosomal tri-snRNP complex assembly (GO:0000244)3.32801271
73histone arginine methylation (GO:0034969)3.31746634
74protein maturation by protein folding (GO:0022417)3.31200340
75negative regulation of fatty acid biosynthetic process (GO:0045717)3.30901460
76DNA double-strand break processing (GO:0000729)3.29001279
77protein complex localization (GO:0031503)3.26994877
78mitochondrial RNA metabolic process (GO:0000959)3.26808013
79regulation of gene silencing by RNA (GO:0060966)3.25678654
80regulation of posttranscriptional gene silencing (GO:0060147)3.25678654
81regulation of gene silencing by miRNA (GO:0060964)3.25678654
82nucleotide-sugar biosynthetic process (GO:0009226)3.24861648
83glial cell migration (GO:0008347)3.23058997
84nucleobase-containing small molecule interconversion (GO:0015949)3.22435744
85intestinal epithelial cell development (GO:0060576)3.21951132
86maturation of 5.8S rRNA (GO:0000460)3.18023052
87positive regulation of protein oligomerization (GO:0032461)3.17586827
88folic acid-containing compound biosynthetic process (GO:0009396)3.16601383
89negative regulation of mRNA metabolic process (GO:1903312)3.15393543
90regulation of DNA damage checkpoint (GO:2000001)3.14991784
91COPII vesicle coating (GO:0048208)3.14988531
92heterochromatin organization (GO:0070828)3.14819317
93retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.14281905
94positive regulation of DNA repair (GO:0045739)3.12953062
95ribosome biogenesis (GO:0042254)3.11205003
96mitotic nuclear envelope disassembly (GO:0007077)3.10848634
97peptidyl-arginine N-methylation (GO:0035246)3.09914994
98peptidyl-arginine methylation (GO:0018216)3.09914994
99negative regulation of chondrocyte differentiation (GO:0032331)3.09184449
100glandular epithelial cell development (GO:0002068)3.08305660
101regulation of double-strand break repair via homologous recombination (GO:0010569)3.04225243
102pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.02990493
103columnar/cuboidal epithelial cell development (GO:0002066)3.02942887
104negative regulation of cartilage development (GO:0061037)3.02090420
105protein localization to chromosome, centromeric region (GO:0071459)3.01754473
106meiotic chromosome segregation (GO:0045132)3.01458003
107mitotic metaphase plate congression (GO:0007080)3.01359016
108sister chromatid segregation (GO:0000819)3.00698501
109trophectodermal cell differentiation (GO:0001829)2.99877237
110regulation of translational termination (GO:0006449)2.99787639
111regulation of mammary gland epithelial cell proliferation (GO:0033599)2.98217635
112anatomical structure regression (GO:0060033)2.96737468
113DNA topological change (GO:0006265)2.96654492
114IMP biosynthetic process (GO:0006188)2.96188820
115embryonic eye morphogenesis (GO:0048048)2.95996541
116protein localization to kinetochore (GO:0034501)2.95249163
117ribonucleoprotein complex biogenesis (GO:0022613)2.94272785
118telomere maintenance via recombination (GO:0000722)2.92050332
119ribosomal small subunit biogenesis (GO:0042274)2.91881139
120ribosome assembly (GO:0042255)2.91111005
121termination of RNA polymerase II transcription (GO:0006369)2.89802053
122pore complex assembly (GO:0046931)2.88122074
123DNA demethylation (GO:0080111)2.87959720
124establishment of viral latency (GO:0019043)2.87125427
125regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.86134008
126nuclear envelope disassembly (GO:0051081)2.86000325
127membrane disassembly (GO:0030397)2.86000325
128DNA strand elongation involved in DNA replication (GO:0006271)2.85988784
129DNA replication checkpoint (GO:0000076)2.85325881
130apoptotic process involved in morphogenesis (GO:0060561)2.84777468
131polarized epithelial cell differentiation (GO:0030859)2.83450621
132tetrahydrofolate metabolic process (GO:0046653)2.82641742
133single strand break repair (GO:0000012)2.82340906
134maturation of SSU-rRNA (GO:0030490)2.81764304
135negative regulation of androgen receptor signaling pathway (GO:0060766)2.79919488
136homocysteine metabolic process (GO:0050667)2.79628515
137regulation of protein oligomerization (GO:0032459)2.79251902
138ribosomal large subunit biogenesis (GO:0042273)2.79068650
139mitotic cell cycle arrest (GO:0071850)2.78910650
140regulation of translational elongation (GO:0006448)2.78665160
141pyrimidine nucleotide catabolic process (GO:0006244)2.77714788
142cellular protein complex localization (GO:0034629)2.76422830
143mitotic nuclear envelope reassembly (GO:0007084)2.76289532
144nuclear envelope reassembly (GO:0031468)2.76289532
145activation of Rac GTPase activity (GO:0032863)2.75556325
146retinoic acid receptor signaling pathway (GO:0048384)2.75437493
147regulation of double-strand break repair (GO:2000779)2.74832461
148folic acid-containing compound metabolic process (GO:0006760)2.71029558
149DNA duplex unwinding (GO:0032508)2.69744837
150pentose-phosphate shunt (GO:0006098)2.68932144
151NADPH regeneration (GO:0006740)2.68793923
152regulation of mitotic spindle organization (GO:0060236)2.67891109
153nucleobase biosynthetic process (GO:0046112)2.66600629
154regulation of mitochondrial translation (GO:0070129)2.66298493
155regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.65650561
156chromosome condensation (GO:0030261)2.61041982
157folic acid metabolic process (GO:0046655)2.60909937
158rRNA transcription (GO:0009303)2.59504946
159ribosomal small subunit assembly (GO:0000028)2.57779996
160IMP metabolic process (GO:0046040)2.57423883
161positive regulation of DNA-dependent DNA replication (GO:2000105)2.56970292
162DNA geometric change (GO:0032392)2.56606489
163planar cell polarity pathway involved in neural tube closure (GO:0090179)2.54920960
164purine nucleobase biosynthetic process (GO:0009113)2.51969868
165glucose catabolic process (GO:0006007)2.51542452
166mitotic recombination (GO:0006312)2.51288391
167nucleosome disassembly (GO:0006337)2.48631134
168protein-DNA complex disassembly (GO:0032986)2.48631134
169positive regulation of nuclease activity (GO:0032075)2.47753011
170activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.45404218
171glucose 6-phosphate metabolic process (GO:0051156)2.43576181
172DNA conformation change (GO:0071103)2.43406488
173regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.41550963
174protein export from nucleus (GO:0006611)2.41340953
1754-hydroxyproline metabolic process (GO:0019471)2.40589470
176pteridine-containing compound biosynthetic process (GO:0042559)2.39129983
177regulation of spindle organization (GO:0090224)2.35823190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.61425407
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.61425407
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.61425407
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.26446407
5* SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.13631156
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.00544746
7E2F7_22180533_ChIP-Seq_HELA_Human2.84563144
8SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.64756097
9SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.56957467
10ZNF263_19887448_ChIP-Seq_K562_Human2.56477060
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55468946
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39954231
13XRN2_22483619_ChIP-Seq_HELA_Human2.34350002
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27430817
15AR_21909140_ChIP-Seq_LNCAP_Human2.25438149
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12372737
17NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.11803324
18DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.10636672
19KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.09389047
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08666841
21POU5F1_16518401_ChIP-PET_MESCs_Mouse2.04458882
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03132206
23TCF3_18692474_ChIP-Seq_MESCs_Mouse2.02762939
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.02128383
25DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.99477711
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98375103
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98051769
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.96213409
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.93819092
30NANOG_21062744_ChIP-ChIP_HESCs_Human1.86380069
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.81032599
32SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.80043156
33TCF3_18692474_ChIP-Seq_MEFs_Mouse1.76835717
34VDR_21846776_ChIP-Seq_THP-1_Human1.72499598
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67834408
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65640338
37PU.1_20513432_ChIP-Seq_Bcells_Mouse1.65476827
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64472889
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.63573240
40CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.63370439
41NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.60039554
42* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59558556
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.58778858
44* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.57966501
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55607465
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55108331
47NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.54157821
48* LXR_22292898_ChIP-Seq_THP-1_Human1.53456851
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.52639358
50NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.52296777
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.50045203
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49224882
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.49167093
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.48189633
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.42410794
56DCP1A_22483619_ChIP-Seq_HELA_Human1.42353062
57FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41385263
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.41237109
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40772779
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.36716955
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36641971
62GABP_19822575_ChIP-Seq_HepG2_Human1.36115964
63CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.35450698
64TP63_17297297_ChIP-ChIP_HaCaT_Human1.34167931
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34033126
66ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.33854548
67HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.32688933
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32623849
69RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32548030
70CLOCK_20551151_ChIP-Seq_293T_Human1.32204126
71CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31219161
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.30522443
73CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.30461897
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30285147
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.29300752
76SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.29203900
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.29077774
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.28653567
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28354508
80POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.28224215
81NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27968453
82MYC_22102868_ChIP-Seq_BL_Human1.27506055
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27248501
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24068456
85HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.23701723
86* ATF3_27146783_Chip-Seq_COLON_Human1.23374776
87SOX2_18692474_ChIP-Seq_MESCs_Mouse1.20998941
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20917311
89RACK7_27058665_Chip-Seq_MCF-7_Human1.20631813
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19828499
91EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19030777
92NANOG_18692474_ChIP-Seq_MESCs_Mouse1.17349745
93TTF2_22483619_ChIP-Seq_HELA_Human1.16870491
94HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15930199
95SOX2_18692474_ChIP-Seq_MEFs_Mouse1.15828205
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15723960
97TFEB_21752829_ChIP-Seq_HELA_Human1.15577830
98CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14932849
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14410348
100* ETS1_21867929_ChIP-Seq_TH2_Mouse1.14057040
101EGR1_19374776_ChIP-ChIP_THP-1_Human1.13444521
102KDM5A_27292631_Chip-Seq_BREAST_Human1.12410274
103ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12028652
104PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11823629
105GABP_17652178_ChIP-ChIP_JURKAT_Human1.11706316
106TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10821421
107ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10112383
108CHD1_26751641_Chip-Seq_LNCaP_Human1.09800550
109NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09754582
110KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09518448
111FOXP3_21729870_ChIP-Seq_TREG_Human1.09206350
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08872157
113PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.08071065
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07920404
115* RARB_24833708_ChIP-Seq_LIVER_Mouse1.07641099
116PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06888392
117ELF1_17652178_ChIP-ChIP_JURKAT_Human1.06689313
118TRIM28_21343339_ChIP-Seq_HEK293_Human1.06150013
119STAT1_20625510_ChIP-Seq_HELA_Human1.06061737
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05965509
121KAP1_27257070_Chip-Seq_ESCs_Mouse1.05665304
122KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05431832
123* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05405190
124EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05365091
125TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05193707
126TBX5_21415370_ChIP-Seq_HL-1_Mouse1.05141211
127ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04867926
128TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02067610
129RARA_24833708_ChIP-Seq_LIVER_Mouse1.01689590
130ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01355908
131SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00806920
132SALL1_21062744_ChIP-ChIP_HESCs_Human1.00438503
133SPI1_26923725_Chip-Seq_HPCs_Mouse1.00137562
134NANOG_16518401_ChIP-PET_MESCs_Mouse0.99905508
135FOXM1_23109430_ChIP-Seq_U2OS_Human0.99651846
136* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99394397
137SRF_21415370_ChIP-Seq_HL-1_Mouse0.99190711
138YY1_22570637_ChIP-Seq_MALME-3M_Human0.98602253
139TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.98546787
140E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98311523
141ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97905708
142FOXP1_21924763_ChIP-Seq_HESCs_Human0.97752075
143NCOR1_26117541_ChIP-Seq_K562_Human0.97468984
144* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97091902
145E2F1_21310950_ChIP-Seq_MCF-7_Human0.97056739
146E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96259606
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96102798
148ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95751948
149KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92692364
150SOX17_20123909_ChIP-Seq_XEN_Mouse0.92395889

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.12358867
2MP0005171_absent_coat_pigmentation3.97274268
3MP0010030_abnormal_orbit_morphology3.43468538
4MP0003705_abnormal_hypodermis_morpholog3.25275947
5MP0004233_abnormal_muscle_weight3.23966192
6MP0003283_abnormal_digestive_organ3.22485911
7MP0009278_abnormal_bone_marrow3.05588407
8MP0002009_preneoplasia3.02785890
9MP0005220_abnormal_exocrine_pancreas2.66254541
10MP0004133_heterotaxia2.42853162
11MP0003890_abnormal_embryonic-extraembry2.34341898
12MP0006072_abnormal_retinal_apoptosis2.23207270
13MP0002249_abnormal_larynx_morphology2.22149911
14MP0010234_abnormal_vibrissa_follicle2.21823426
15MP0001730_embryonic_growth_arrest2.10399397
16MP0003119_abnormal_digestive_system2.08019022
17MP0005257_abnormal_intraocular_pressure2.07899737
18MP0005451_abnormal_body_composition2.03489249
19MP0004272_abnormal_basement_membrane2.02385537
20MP0002282_abnormal_trachea_morphology1.98251866
21MP0000537_abnormal_urethra_morphology1.97854053
22MP0008995_early_reproductive_senescence1.95407813
23MP0010094_abnormal_chromosome_stability1.92164491
24MP0002653_abnormal_ependyma_morphology1.91555212
25MP0003786_premature_aging1.89488159
26MP0004858_abnormal_nervous_system1.80725136
27MP0001666_abnormal_nutrient_absorption1.78856972
28MP0004264_abnormal_extraembryonic_tissu1.77568254
29MP0004957_abnormal_blastocyst_morpholog1.75616500
30MP0008058_abnormal_DNA_repair1.73277690
31MP0003123_paternal_imprinting1.70789519
32MP0003566_abnormal_cell_adhesion1.68802732
33MP0008007_abnormal_cellular_replicative1.68773941
34MP0000566_synostosis1.66846756
35MP0000470_abnormal_stomach_morphology1.65902337
36MP0005174_abnormal_tail_pigmentation1.62882970
37MP0009672_abnormal_birth_weight1.60403360
38MP0000490_abnormal_crypts_of1.59929853
39MP0000762_abnormal_tongue_morphology1.53990298
40MP0005076_abnormal_cell_differentiation1.53977318
41MP0000462_abnormal_digestive_system1.52597603
42MP0003984_embryonic_growth_retardation1.51989586
43MP0002089_abnormal_postnatal_growth/wei1.46651738
44MP0004134_abnormal_chest_morphology1.46268336
45MP0005083_abnormal_biliary_tract1.46215336
46MP0002088_abnormal_embryonic_growth/wei1.43808447
47MP0001293_anophthalmia1.42643985
48MP0002084_abnormal_developmental_patter1.42403914
49MP0002111_abnormal_tail_morphology1.41328124
50MP0004197_abnormal_fetal_growth/weight/1.40670985
51MP0005508_abnormal_skeleton_morphology1.40227036
52MP0003693_abnormal_embryo_hatching1.39229906
53MP0001849_ear_inflammation1.38791149
54MP0000678_abnormal_parathyroid_gland1.37836890
55MP0000371_diluted_coat_color1.36233263
56MP0003172_abnormal_lysosome_physiology1.36195672
57MP0000015_abnormal_ear_pigmentation1.35711687
58MP0001661_extended_life_span1.34919497
59MP0005501_abnormal_skin_physiology1.34743698
60MP0003315_abnormal_perineum_morphology1.34366496
61MP0004185_abnormal_adipocyte_glucose1.33701696
62MP0008932_abnormal_embryonic_tissue1.31497517
63MP0003755_abnormal_palate_morphology1.31019763
64MP0002254_reproductive_system_inflammat1.29679247
65MP0002085_abnormal_embryonic_tissue1.29675143
66MP0003718_maternal_effect1.28994569
67MP0003111_abnormal_nucleus_morphology1.25470076
68MP0005645_abnormal_hypothalamus_physiol1.25368930
69MP0003136_yellow_coat_color1.24807747
70MP0000049_abnormal_middle_ear1.24580557
71MP0002932_abnormal_joint_morphology1.24310468
72MP0002116_abnormal_craniofacial_bone1.22399530
73MP0000516_abnormal_urinary_system1.21783884
74MP0005367_renal/urinary_system_phenotyp1.21783884
75MP0003453_abnormal_keratinocyte_physiol1.21586295
76MP0001697_abnormal_embryo_size1.20941425
77MP0003937_abnormal_limbs/digits/tail_de1.20151291
78MP0000579_abnormal_nail_morphology1.19571023
79MP0010352_gastrointestinal_tract_polyps1.17151459
80MP0005075_abnormal_melanosome_morpholog1.16430855
81MP0002086_abnormal_extraembryonic_tissu1.15623336
82MP0005365_abnormal_bile_salt1.14628279
83MP0005623_abnormal_meninges_morphology1.12621868
84MP0003941_abnormal_skin_development1.12350553
85MP0001348_abnormal_lacrimal_gland1.11428179
86MP0002114_abnormal_axial_skeleton1.11059985
87MP0000432_abnormal_head_morphology1.10829833
88MP0008877_abnormal_DNA_methylation1.07563063
89MP0002075_abnormal_coat/hair_pigmentati1.06818294
90MP0005408_hypopigmentation1.06165014
91MP0003935_abnormal_craniofacial_develop1.04909366
92MP0001340_abnormal_eyelid_morphology1.04156301
93MP0000313_abnormal_cell_death1.03762923
94MP0000163_abnormal_cartilage_morphology1.03170579
95MP0002060_abnormal_skin_morphology1.02967187
96MP0001186_pigmentation_phenotype1.01014232
97MP0003115_abnormal_respiratory_system0.98668182
98MP0001545_abnormal_hematopoietic_system0.98591330
99MP0005397_hematopoietic_system_phenotyp0.98591330
100MP0002938_white_spotting0.98291352
101MP0000358_abnormal_cell_content/0.98024724
102MP0003077_abnormal_cell_cycle0.95787458
103MP0000534_abnormal_ureter_morphology0.95759913
104MP0009697_abnormal_copulation0.95339610
105MP0005380_embryogenesis_phenotype0.95270667
106MP0001672_abnormal_embryogenesis/_devel0.95270667
107MP0001881_abnormal_mammary_gland0.93853467
108MP0003567_abnormal_fetal_cardiomyocyte0.93790515
109MP0001346_abnormal_lacrimal_gland0.93776857
110MP0000350_abnormal_cell_proliferation0.93729733
111MP0000428_abnormal_craniofacial_morphol0.90970665
112MP0009250_abnormal_appendicular_skeleto0.90493792
113MP0000003_abnormal_adipose_tissue0.90076921
114MP0000639_abnormal_adrenal_gland0.88833713
115MP0002092_abnormal_eye_morphology0.88755551
116MP0003942_abnormal_urinary_system0.88128483
117MP0003186_abnormal_redox_activity0.85899392
118MP0002108_abnormal_muscle_morphology0.85586539
119MP0000751_myopathy0.85433758
120MP0005503_abnormal_tendon_morphology0.84749212
121MP0005058_abnormal_lysosome_morphology0.83835590
122MP0005384_cellular_phenotype0.82559684
123MP0003385_abnormal_body_wall0.82188252
124MP0002693_abnormal_pancreas_physiology0.81744747
125MP0005621_abnormal_cell_physiology0.81334995
126MP0002109_abnormal_limb_morphology0.80787895
127MP0000613_abnormal_salivary_gland0.79629399
128MP0003045_fibrosis0.79222095
129MP0001915_intracranial_hemorrhage0.79008205
130MP0009703_decreased_birth_body0.78676185
131MP0008438_abnormal_cutaneous_collagen0.78025645
132MP0002877_abnormal_melanocyte_morpholog0.77039741
133MP0003959_abnormal_lean_body0.76624548
134MP0009384_cardiac_valve_regurgitation0.76197031
135MP0002080_prenatal_lethality0.75928126
136MP0002751_abnormal_autonomic_nervous0.75866825
137MP0002115_abnormal_skeleton_extremities0.75642595
138MP0008260_abnormal_autophagy0.75508412
139MP0006035_abnormal_mitochondrial_morpho0.75338819
140MP0002697_abnormal_eye_size0.73772975
141MP0000747_muscle_weakness0.73642468
142MP0002163_abnormal_gland_morphology0.72933359
143MP0000467_abnormal_esophagus_morphology0.72915552
144MP0000681_abnormal_thyroid_gland0.72661906
145MP0002269_muscular_atrophy0.72660322
146MP0001286_abnormal_eye_development0.72524552
147MP0004782_abnormal_surfactant_physiolog0.70943375
148MP0001944_abnormal_pancreas_morphology0.70661156
149MP0003861_abnormal_nervous_system0.70583013
150MP0010307_abnormal_tumor_latency0.69236957
151MP0002796_impaired_skin_barrier0.68791185

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.11918318
2Concave nail (HP:0001598)4.48760299
3Premature rupture of membranes (HP:0001788)4.34015422
4Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.32565587
5Facial hemangioma (HP:0000329)4.15207477
6Rectovaginal fistula (HP:0000143)3.86902411
7Rectal fistula (HP:0100590)3.86902411
8Vertebral hypoplasia (HP:0008417)3.69440783
9Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.69440783
10Turricephaly (HP:0000262)3.60049883
11Joint stiffness (HP:0001387)3.59084091
12Ulnar bowing (HP:0003031)3.57618481
13Intestinal atresia (HP:0011100)3.53212132
14Hypoplastic ischia (HP:0003175)3.45262341
15Poikiloderma (HP:0001029)3.42370069
16Abnormal gallbladder physiology (HP:0012438)3.41039162
17Cholecystitis (HP:0001082)3.41039162
18Intestinal fistula (HP:0100819)3.41007430
19Short humerus (HP:0005792)3.40809124
20Increased IgM level (HP:0003496)3.37705832
21Short chin (HP:0000331)3.30417936
22Alopecia of scalp (HP:0002293)3.28632065
23Aplasia/hypoplasia of the humerus (HP:0006507)3.28351610
24Vaginal fistula (HP:0004320)3.27766594
25Pustule (HP:0200039)3.24173077
26Protrusio acetabuli (HP:0003179)3.20793453
27Large for gestational age (HP:0001520)3.19928158
28Hyperacusis (HP:0010780)3.18055821
29Coronal craniosynostosis (HP:0004440)3.13150102
30Tongue fasciculations (HP:0001308)3.07230246
31Abnormality of the ischium (HP:0003174)3.02665829
32Abnormal hemoglobin (HP:0011902)3.01203345
33Hypochromic microcytic anemia (HP:0004840)3.00456364
34Orthostatic hypotension (HP:0001278)3.00319032
35Alacrima (HP:0000522)2.97572973
36Mucopolysacchariduria (HP:0008155)2.96932257
37Urinary glycosaminoglycan excretion (HP:0003541)2.96932257
38Abnormality of glycolysis (HP:0004366)2.94703868
39Absent radius (HP:0003974)2.93128540
40Annular pancreas (HP:0001734)2.92728142
41Pancreatic islet-cell hyperplasia (HP:0004510)2.87236311
42Metaphyseal cupping (HP:0003021)2.76647443
43Epiphyseal dysplasia (HP:0002656)2.74398956
44Aplasia involving forearm bones (HP:0009822)2.73444168
45Absent forearm bone (HP:0003953)2.73444168
46Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.72690540
47Insomnia (HP:0100785)2.71486573
48Muscle fibrillation (HP:0010546)2.69747624
49Abnormality of polysaccharide metabolism (HP:0011012)2.68932047
50Abnormality of glycosaminoglycan metabolism (HP:0004371)2.68932047
51Abnormality of mucopolysaccharide metabolism (HP:0011020)2.68932047
52Anteriorly placed anus (HP:0001545)2.68488169
53Increased nuchal translucency (HP:0010880)2.67576766
54Absent thumb (HP:0009777)2.66869274
55Popliteal pterygium (HP:0009756)2.65436333
56Bifid uvula (HP:0000193)2.62498468
57Dysautonomia (HP:0002459)2.62431014
58Trismus (HP:0000211)2.60317757
59Squamous cell carcinoma (HP:0002860)2.59934920
60Dysostosis multiplex (HP:0000943)2.57299984
61Renal duplication (HP:0000075)2.55573301
62Biconcave vertebral bodies (HP:0004586)2.53843397
63Aplasia of the musculature (HP:0100854)2.53659295
64Irregular epiphyses (HP:0010582)2.53028366
65Male infertility (HP:0003251)2.48551702
66Volvulus (HP:0002580)2.47997190
67Abnormality of male internal genitalia (HP:0000022)2.46231243
68Abnormality of the aortic arch (HP:0012303)2.45464206
69Asymmetry of the thorax (HP:0001555)2.44324078
70Hypoplasia of the capital femoral epiphysis (HP:0003090)2.43354097
71Decreased lacrimation (HP:0000633)2.43141835
72Microvesicular hepatic steatosis (HP:0001414)2.42782242
73Chromosomal breakage induced by crosslinking agents (HP:0003221)2.42090502
74Patellar aplasia (HP:0006443)2.40571171
75Increased serum pyruvate (HP:0003542)2.39191905
76Pterygium (HP:0001059)2.38336953
77Abnormality of dentin (HP:0010299)2.35567100
78Abnormality of the umbilical cord (HP:0010881)2.34754847
79Aplasia/Hypoplasia involving the vertebral column (HP:0008518)2.34691901
80Selective tooth agenesis (HP:0001592)2.33292902
81Breech presentation (HP:0001623)2.32696527
82Exocrine pancreatic insufficiency (HP:0001738)2.31710784
83Small epiphyses (HP:0010585)2.30450799
84Premature graying of hair (HP:0002216)2.28321626
85Broad alveolar ridges (HP:0000187)2.27955618
86Mild short stature (HP:0003502)2.26435134
87Diaphragmatic weakness (HP:0009113)2.26405915
88Progressive muscle weakness (HP:0003323)2.26321364
89Disproportionate tall stature (HP:0001519)2.26165726
90Multiple enchondromatosis (HP:0005701)2.26114659
91Upper limb muscle weakness (HP:0003484)2.22347412
92Chromsome breakage (HP:0040012)2.22228086
93Abnormality of endocrine pancreas physiology (HP:0012093)2.22044988
94Abnormality of the pancreatic islet cells (HP:0006476)2.22044988
95Cortical dysplasia (HP:0002539)2.21942717
96Aplasia/Hypoplasia of the patella (HP:0006498)2.21152635
97Long palpebral fissure (HP:0000637)2.20744551
98Capillary hemangiomas (HP:0005306)2.19858174
99Increased number of teeth (HP:0011069)2.19478353
100Hamartoma (HP:0010566)2.19230181
101Hypotrichosis (HP:0001006)2.19136296
102Maternal diabetes (HP:0009800)2.19123606
103Median cleft lip (HP:0000161)2.18584125
104Reticulocytopenia (HP:0001896)2.17404125
105Amelogenesis imperfecta (HP:0000705)2.15378144
106Overriding aorta (HP:0002623)2.14963817
107Achilles tendon contracture (HP:0001771)2.13180148
108Deviation of the thumb (HP:0009603)2.11555648
109Abnormality of reticulocytes (HP:0004312)2.11168307
110Gastrointestinal atresia (HP:0002589)2.09966618
111Hypoplasia of the ulna (HP:0003022)2.09749850
112Hypoplasia of the radius (HP:0002984)2.09320845
113Choanal stenosis (HP:0000452)2.08723262
114Albinism (HP:0001022)2.08685412
115Spinal muscular atrophy (HP:0007269)2.08513601
116Reticulocytosis (HP:0001923)2.08214498
117Bladder diverticulum (HP:0000015)2.06955097
118Basal cell carcinoma (HP:0002671)2.04448766
119Proximal placement of thumb (HP:0009623)2.03638433
120Thin ribs (HP:0000883)2.02156609
121Vertebral compression fractures (HP:0002953)2.02070352
122Absent epiphyses (HP:0010577)1.99142440
123Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.99142440
124Vertebral clefting (HP:0008428)1.98246716
125Carpal bone hypoplasia (HP:0001498)1.98144045
126Microglossia (HP:0000171)1.97297950
127Abnormality of the Achilles tendon (HP:0005109)1.96120387
128Elfin facies (HP:0004428)1.95995627
129Vertebral fusion (HP:0002948)1.91115024
130Abnormal tarsal ossification (HP:0008369)1.90885094
131Overlapping toe (HP:0001845)1.90825201
132Testicular atrophy (HP:0000029)1.90203095
133Nonimmune hydrops fetalis (HP:0001790)1.89181734
134Short 5th finger (HP:0009237)1.88748705
135Abnormality of the calcaneus (HP:0008364)1.88308310
136Abnormalities of placenta or umbilical cord (HP:0001194)1.88281590
137Abnormality of cells of the erythroid lineage (HP:0012130)1.88242593
138Hyperparathyroidism (HP:0000843)1.88090747
139Bowing of the arm (HP:0006488)1.88071406
140Bowed forearm bones (HP:0003956)1.88071406
141Abnormal delivery (HP:0001787)1.87780722
142Distal upper limb amyotrophy (HP:0007149)1.87639330
143Upper limb amyotrophy (HP:0009129)1.87639330
144Patellar dislocation (HP:0002999)1.87567407
145Shallow orbits (HP:0000586)1.86086155
146Small hand (HP:0200055)1.85729384
147Birth length less than 3rd percentile (HP:0003561)1.85258265
148Missing ribs (HP:0000921)1.84917526
149Sex reversal (HP:0012245)1.84784787
150Abnormal sex determination (HP:0012244)1.84784787
151Generalized amyotrophy (HP:0003700)1.84778616
152Cholelithiasis (HP:0001081)1.83994188
153Abnormality of the tricuspid valve (HP:0001702)1.82809058
154Growth hormone excess (HP:0000845)1.81351837
155Carpal synostosis (HP:0009702)1.79370733
156Truncus arteriosus (HP:0001660)1.79260969
157Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79047246
158Septate vagina (HP:0001153)1.78784099
159Flat cornea (HP:0007720)1.77189620
160Rough bone trabeculation (HP:0100670)1.76200153
161Breast hypoplasia (HP:0003187)1.75974555
162Glossoptosis (HP:0000162)1.74716599
163Fragile skin (HP:0001030)1.73816501
164Abnormality of the acetabulum (HP:0003170)1.73175062
165Ankle contracture (HP:0006466)1.72171211
166Abnormality of carpal bone ossification (HP:0006257)1.71960367
167Abnormality of pain sensation (HP:0010832)1.71363656
168Impaired pain sensation (HP:0007328)1.71363656
169Abnormal number of erythroid precursors (HP:0012131)1.71037947
170Hand muscle atrophy (HP:0009130)1.70056092
171Deep venous thrombosis (HP:0002625)1.68345577
172Soft skin (HP:0000977)1.67025225
173Facial cleft (HP:0002006)1.64135856
174Abnormal umbilical cord blood vessels (HP:0011403)1.63255447
175Single umbilical artery (HP:0001195)1.63255447
176Abnormality of the fetal cardiovascular system (HP:0010948)1.63255447
177Flat acetabular roof (HP:0003180)1.62452474
178Renovascular hypertension (HP:0100817)1.61744738
179Bowel diverticulosis (HP:0005222)1.61613289
180Duplication of thumb phalanx (HP:0009942)1.61255476
181Calcaneovalgus deformity (HP:0001848)1.60779672
182Hyperthyroidism (HP:0000836)1.59761823
183Abnormal gallbladder morphology (HP:0012437)1.59391602
184Ankyloglossia (HP:0010296)1.59096251
185Back pain (HP:0003418)1.58717043
186Abnormality of the gallbladder (HP:0005264)1.57319548
187Hypoparathyroidism (HP:0000829)1.56177697
188Progressive external ophthalmoplegia (HP:0000590)1.55473472
189High anterior hairline (HP:0009890)1.54696671
190Spinal rigidity (HP:0003306)1.54435151
191Secondary amenorrhea (HP:0000869)1.52843457
192Gout (HP:0001997)1.52204889
193Slender long bone (HP:0003100)1.50159307
194* Blue sclerae (HP:0000592)1.49585296
195Generalized hypotonia (HP:0001290)1.49482049

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.19542138
2DDR25.42566916
3ICK5.38775907
4MAP3K63.76487303
5EEF2K3.41090164
6SMG13.38429886
7BUB13.31868304
8TRIB33.23172115
9PINK12.82269527
10MAP3K112.64783450
11UHMK12.59262527
12MATK2.53468995
13PIM22.48775691
14VRK22.41216197
15TYRO32.38453926
16YES12.37316557
17EIF2AK12.33123620
18FGR2.32986183
19PBK2.22432013
20AKT32.21378263
21PRKD22.15460154
22BMX2.12602307
23DYRK1B2.02134032
24SIK12.00302133
25TSSK61.99472711
26NEK11.97110625
27CSK1.93384153
28PDGFRA1.92461244
29MST1R1.88805117
30CDK71.85387982
31PAK41.84037322
32DAPK11.81069741
33SRPK11.80044836
34BCKDK1.72213918
35FGFR41.66201962
36SCYL21.58567948
37PKN21.56762972
38WNK41.41556352
39EPHA21.38889081
40PIM11.31653058
41RPS6KL11.28371127
42RPS6KC11.28371127
43LATS21.27667528
44TRPM71.27007610
45BRSK11.25409233
46PRKD31.22934608
47MAP3K81.22819637
48CDC42BPA1.20965655
49CHEK21.14485842
50TAOK21.13879669
51CDK61.13016764
52HIPK21.11133994
53RPS6KA61.10648389
54TESK11.10599161
55GSK3A1.07459611
56PRPF4B1.06659086
57PLK30.98926512
58TAF10.97621282
59ARAF0.97580218
60LMTK20.96743446
61BRAF0.96333814
62DYRK30.94046586
63TESK20.93655211
64ILK0.87045689
65MTOR0.85581552
66PLK10.85463159
67NTRK10.83256151
68RPS6KB20.82232426
69MAPK110.79395767
70PASK0.76234509
71ERBB40.75705631
72EIF2AK30.75544338
73DYRK20.75053767
74ATR0.73120062
75STK38L0.69326815
76AKT20.67194604
77ERBB30.66752327
78MAP2K20.65119003
79RPS6KB10.64131050
80MAP3K100.63837549
81PHKG20.62986162
82PHKG10.62986162
83MAP3K30.62378961
84CLK10.62377000
85LIMK10.62267738
86RPS6KA10.61885156
87PLK40.61765564
88MAPKAPK30.60241458
89TTN0.60201837
90CAMK1D0.60025076
91STK40.59976738
92PTK60.59147760
93ALK0.57645738
94PRKAA10.56607994
95CDK40.56033115
96PRKCI0.55094146
97CDK120.54469066
98FLT30.54418052
99LATS10.54311431
100PAK20.53498977
101PAK10.51657691
102ERN10.50547990
103CSNK2A10.50443932
104STK390.49814635
105AURKA0.49030990
106RPS6KA40.48853168
107CDK11A0.48198082
108MAPK30.47215961
109FGFR10.47205772
110LRRK20.47146153
111KSR20.46981421
112CDK150.46591654
113PDGFRB0.46493726
114CDK180.45129625
115* CDK20.44887937
116MAPK10.43220111
117VRK10.42012719
118PTK20.41183332
119IRAK20.40919317
120BRSK20.39275562
121CDK140.39183461
122ZAK0.38941855
123PRKG20.38430846
124TNK20.38426524
125DAPK30.38150288
126MAPK140.37626382
127CHEK10.37505663
128NME10.37256870
129ATM0.36107696
130MKNK20.35864003
131NME20.35532152
132IRAK30.35389537
133RAF10.34373261
134MET0.33619155
135AURKB0.32233463
136CSNK2A20.31998421
137STK30.30633408
138LYN0.29875244
139WEE10.28437755
140AKT10.27756158
141EGFR0.27549967
142STK160.26867547
143CDK10.26517212
144CAMK2B0.26328801
145TAOK30.26103585
146MAPK100.25265400
147INSRR0.24775278
148INSR0.24325636
149TTK0.22242178
150NEK20.21628494
151CSNK1G10.21509577
152CAMK2G0.20364886
153CDK80.19719004
154CAMK2D0.18870439
155CDC70.17480265
156MAPKAPK20.17047157

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.26619751
2Base excision repair_Homo sapiens_hsa034103.99141174
3DNA replication_Homo sapiens_hsa030303.29987636
4Fatty acid biosynthesis_Homo sapiens_hsa000613.29240387
5Maturity onset diabetes of the young_Homo sapiens_hsa049503.24392281
6Protein export_Homo sapiens_hsa030602.57361864
7Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.57243399
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.55606359
9Nucleotide excision repair_Homo sapiens_hsa034202.38227211
10Folate biosynthesis_Homo sapiens_hsa007902.37885257
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.34768879
12Homologous recombination_Homo sapiens_hsa034402.05234375
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.04178510
14Protein digestion and absorption_Homo sapiens_hsa049742.01926741
15Fanconi anemia pathway_Homo sapiens_hsa034601.96324547
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.93981139
17Vitamin B6 metabolism_Homo sapiens_hsa007501.93152523
18Hedgehog signaling pathway_Homo sapiens_hsa043401.89613471
19Carbon metabolism_Homo sapiens_hsa012001.86633758
20Pancreatic secretion_Homo sapiens_hsa049721.86422872
21Notch signaling pathway_Homo sapiens_hsa043301.85717953
22RNA transport_Homo sapiens_hsa030131.82126728
23Pentose phosphate pathway_Homo sapiens_hsa000301.77211037
24Spliceosome_Homo sapiens_hsa030401.73507431
25Hippo signaling pathway_Homo sapiens_hsa043901.71801056
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.71358430
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70011268
28Circadian rhythm_Homo sapiens_hsa047101.68492847
29Pyruvate metabolism_Homo sapiens_hsa006201.57661095
30p53 signaling pathway_Homo sapiens_hsa041151.57306425
31mRNA surveillance pathway_Homo sapiens_hsa030151.56765040
32One carbon pool by folate_Homo sapiens_hsa006701.54041348
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.49165321
34Fat digestion and absorption_Homo sapiens_hsa049751.46800839
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.43194891
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.41538816
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.40136946
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38884475
39TGF-beta signaling pathway_Homo sapiens_hsa043501.37139364
40Basal cell carcinoma_Homo sapiens_hsa052171.37124028
41Adherens junction_Homo sapiens_hsa045201.36076724
42mTOR signaling pathway_Homo sapiens_hsa041501.33740071
43N-Glycan biosynthesis_Homo sapiens_hsa005101.33572348
44Cell cycle_Homo sapiens_hsa041101.26660539
45Wnt signaling pathway_Homo sapiens_hsa043101.23435606
46* Arginine and proline metabolism_Homo sapiens_hsa003301.19137398
47Bladder cancer_Homo sapiens_hsa052191.18041890
48Steroid biosynthesis_Homo sapiens_hsa001001.17476289
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16466980
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13737182
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10375254
52Arginine biosynthesis_Homo sapiens_hsa002201.09533786
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08840915
54Ribosome_Homo sapiens_hsa030101.08556980
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07884339
56Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07159233
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.05739849
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01073662
59Sulfur relay system_Homo sapiens_hsa041220.99326442
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97987141
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.96750904
62RNA polymerase_Homo sapiens_hsa030200.95660733
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90355442
64Fatty acid elongation_Homo sapiens_hsa000620.89421677
65Fructose and mannose metabolism_Homo sapiens_hsa000510.82411750
66Galactose metabolism_Homo sapiens_hsa000520.81760168
67Purine metabolism_Homo sapiens_hsa002300.78248898
68Basal transcription factors_Homo sapiens_hsa030220.76879136
69Lysine degradation_Homo sapiens_hsa003100.75320526
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73579884
71MicroRNAs in cancer_Homo sapiens_hsa052060.70868104
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66792953
73Colorectal cancer_Homo sapiens_hsa052100.65725769
74Pyrimidine metabolism_Homo sapiens_hsa002400.64267275
75Linoleic acid metabolism_Homo sapiens_hsa005910.63783079
76Other glycan degradation_Homo sapiens_hsa005110.63126916
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62941692
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.61923699
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61805467
80Vibrio cholerae infection_Homo sapiens_hsa051100.61654906
81RNA degradation_Homo sapiens_hsa030180.57520824
82PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55427405
83Prostate cancer_Homo sapiens_hsa052150.54828422
84Selenocompound metabolism_Homo sapiens_hsa004500.53812189
85Legionellosis_Homo sapiens_hsa051340.53575810
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52989686
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52574589
88Tight junction_Homo sapiens_hsa045300.52355842
89Arachidonic acid metabolism_Homo sapiens_hsa005900.51938512
90Viral carcinogenesis_Homo sapiens_hsa052030.51735378
91Phenylalanine metabolism_Homo sapiens_hsa003600.51232378
92VEGF signaling pathway_Homo sapiens_hsa043700.48913962
93Proteasome_Homo sapiens_hsa030500.48318091
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48051833
95* Metabolic pathways_Homo sapiens_hsa011000.47686670
96Vitamin digestion and absorption_Homo sapiens_hsa049770.47073297
97Small cell lung cancer_Homo sapiens_hsa052220.46635863
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45989938
99Renin-angiotensin system_Homo sapiens_hsa046140.44257167
100* Biosynthesis of amino acids_Homo sapiens_hsa012300.42974628
101Insulin signaling pathway_Homo sapiens_hsa049100.41911028
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41642731
103Pancreatic cancer_Homo sapiens_hsa052120.39597814
104Shigellosis_Homo sapiens_hsa051310.39256666
105Huntingtons disease_Homo sapiens_hsa050160.38852949
106Non-small cell lung cancer_Homo sapiens_hsa052230.37907790
107Non-homologous end-joining_Homo sapiens_hsa034500.37735495
108Epstein-Barr virus infection_Homo sapiens_hsa051690.36475952
109ErbB signaling pathway_Homo sapiens_hsa040120.35989900
110Thyroid cancer_Homo sapiens_hsa052160.35719587
111Tyrosine metabolism_Homo sapiens_hsa003500.35635397
112Focal adhesion_Homo sapiens_hsa045100.35191636
113Propanoate metabolism_Homo sapiens_hsa006400.35184090
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34488981
115Oocyte meiosis_Homo sapiens_hsa041140.34394595
116Glutathione metabolism_Homo sapiens_hsa004800.34382243
117Lysosome_Homo sapiens_hsa041420.32766064
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32738413
119ECM-receptor interaction_Homo sapiens_hsa045120.31390458
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31004617
121Prion diseases_Homo sapiens_hsa050200.30983666
122Acute myeloid leukemia_Homo sapiens_hsa052210.29951705
123Endometrial cancer_Homo sapiens_hsa052130.29570369
124Glycerolipid metabolism_Homo sapiens_hsa005610.28673890
125AMPK signaling pathway_Homo sapiens_hsa041520.27843705
126Choline metabolism in cancer_Homo sapiens_hsa052310.24925156
127HTLV-I infection_Homo sapiens_hsa051660.24438745
128Chronic myeloid leukemia_Homo sapiens_hsa052200.23919965
129Pathways in cancer_Homo sapiens_hsa052000.23452413
130Melanoma_Homo sapiens_hsa052180.22318146
131Viral myocarditis_Homo sapiens_hsa054160.20388921
132Proteoglycans in cancer_Homo sapiens_hsa052050.20165737
133Fatty acid metabolism_Homo sapiens_hsa012120.18551459
134Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18389587

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