PXYLP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)8.01104830
2Golgi transport vesicle coating (GO:0048200)8.01104830
3protein retention in ER lumen (GO:0006621)6.72570387
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.70544298
5dopaminergic neuron differentiation (GO:0071542)6.34290644
6disruption of cells of other organism involved in symbiotic interaction (GO:0051818)6.24952973
7killing of cells in other organism involved in symbiotic interaction (GO:0051883)6.24952973
8pyrimidine nucleobase catabolic process (GO:0006208)5.67882567
9defense response to fungus (GO:0050832)5.64875861
10keratan sulfate catabolic process (GO:0042340)5.61015340
11response to pheromone (GO:0019236)4.82928346
12negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.75103542
13disruption of cells of other organism (GO:0044364)4.72496093
14killing of cells of other organism (GO:0031640)4.72496093
15neutrophil mediated immunity (GO:0002446)4.69041428
16sequestering of metal ion (GO:0051238)4.56727951
17presynaptic membrane assembly (GO:0097105)4.42564923
18response to fungus (GO:0009620)4.34253013
19nucleobase catabolic process (GO:0046113)4.33579867
20UDP-N-acetylglucosamine metabolic process (GO:0006047)4.32074635
21cartilage condensation (GO:0001502)4.31014103
22cell aggregation (GO:0098743)4.31014103
23myeloid leukocyte mediated immunity (GO:0002444)4.26646147
24limb bud formation (GO:0060174)4.25986021
25chondrocyte development (GO:0002063)4.12342656
26presynaptic membrane organization (GO:0097090)4.11254551
27cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.02893489
28behavioral response to nicotine (GO:0035095)3.99898249
29COPII vesicle coating (GO:0048208)3.97064355
30regulation of type B pancreatic cell apoptotic process (GO:2000674)3.94402950
31regulation of mesenchymal cell apoptotic process (GO:2001053)3.93125806
32gamma-aminobutyric acid transport (GO:0015812)3.92907452
33exocrine pancreas development (GO:0031017)3.88913044
34leukocyte aggregation (GO:0070486)3.84388707
35lipopolysaccharide biosynthetic process (GO:0009103)3.81551677
36collagen fibril organization (GO:0030199)3.76763420
37neural tube formation (GO:0001841)3.75332032
38retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.72288032
39postsynaptic membrane organization (GO:0001941)3.59520886
40nucleotide-sugar metabolic process (GO:0009225)3.56477031
41ribosomal small subunit assembly (GO:0000028)3.55535366
42protein N-linked glycosylation via asparagine (GO:0018279)3.55509573
43peptidyl-asparagine modification (GO:0018196)3.54051914
44detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.48704799
45leukocyte migration involved in inflammatory response (GO:0002523)3.44859876
46negative regulation of phagocytosis (GO:0050765)3.42905191
47negative regulation of growth of symbiont in host (GO:0044130)3.39729142
48negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.39729142
49modulation of growth of symbiont involved in interaction with host (GO:0044144)3.39729142
50regulation of growth of symbiont in host (GO:0044126)3.39729142
51neuron cell-cell adhesion (GO:0007158)3.36469563
52chondroitin sulfate biosynthetic process (GO:0030206)3.35057964
53sulfation (GO:0051923)3.34849535
54endosome to pigment granule transport (GO:0043485)3.32816795
55endosome to melanosome transport (GO:0035646)3.32816795
56vesicle coating (GO:0006901)3.32591252
57mitochondrial calcium ion transport (GO:0006851)3.31265848
58reflex (GO:0060004)3.30623249
59axon extension involved in axon guidance (GO:0048846)3.25932767
60neuron projection extension involved in neuron projection guidance (GO:1902284)3.25932767
61nonmotile primary cilium assembly (GO:0035058)3.25628769
62protein N-linked glycosylation (GO:0006487)3.25302810
63negative regulation of cytosolic calcium ion concentration (GO:0051481)3.23788879
64kidney morphogenesis (GO:0060993)3.23711907
65signal peptide processing (GO:0006465)3.21013357
66head development (GO:0060322)3.17959025
67peptidyl-proline hydroxylation (GO:0019511)3.16653645
68lipopolysaccharide metabolic process (GO:0008653)3.15833025
69G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.12995202
70peptide catabolic process (GO:0043171)3.10430601
71positive regulation of respiratory burst (GO:0060267)3.10078659
72positive regulation of hormone biosynthetic process (GO:0046886)3.08709169
73central nervous system projection neuron axonogenesis (GO:0021952)3.08660948
74negative regulation of axon guidance (GO:1902668)3.07634026
75notochord development (GO:0030903)3.02733451
76regulation of collateral sprouting (GO:0048670)3.02053101
77negative regulation of synaptic transmission, GABAergic (GO:0032229)2.99391508
78indolalkylamine metabolic process (GO:0006586)2.99042999
79behavioral response to ethanol (GO:0048149)2.98952121
80protein hydroxylation (GO:0018126)2.98647481
81type B pancreatic cell development (GO:0003323)2.98279708
82negative regulation of RNA splicing (GO:0033119)2.98109589
83fucosylation (GO:0036065)2.97130257
84necroptotic process (GO:0070266)2.95900860
85negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.95694772
86regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.95440882
87epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.94401470
88intra-Golgi vesicle-mediated transport (GO:0006891)2.92814736
89dentate gyrus development (GO:0021542)2.92193523
90nucleotide-sugar biosynthetic process (GO:0009226)2.91791915
91hindbrain development (GO:0030902)2.90046993
92detection of light stimulus involved in sensory perception (GO:0050962)2.88872331
93detection of light stimulus involved in visual perception (GO:0050908)2.88872331
94purine ribonucleotide transport (GO:0015868)2.88685495
95retinal ganglion cell axon guidance (GO:0031290)2.88371568
96transmission of nerve impulse (GO:0019226)2.88170289
97neuronal action potential (GO:0019228)2.87611498
98regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.87285109
99protein localization to synapse (GO:0035418)2.87047018
100vocalization behavior (GO:0071625)2.85802301
101retinal cone cell development (GO:0046549)2.85566780
102auditory behavior (GO:0031223)2.85296924
103startle response (GO:0001964)2.85257038
104adenine nucleotide transport (GO:0051503)2.83942589
105somite development (GO:0061053)2.81801746
106primitive streak formation (GO:0090009)2.81478663
107inner ear receptor stereocilium organization (GO:0060122)2.80775958
108astrocyte differentiation (GO:0048708)2.78980718
109axonal fasciculation (GO:0007413)2.78055892
110purine-containing compound salvage (GO:0043101)2.77480755
111indole-containing compound catabolic process (GO:0042436)2.77375949
112indolalkylamine catabolic process (GO:0046218)2.77375949
113tryptophan catabolic process (GO:0006569)2.77375949
114proteoglycan metabolic process (GO:0006029)2.76654620
115activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.76497959
116positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.75765685
117cerebellum development (GO:0021549)2.75587742
118positive regulation of nuclease activity (GO:0032075)2.75580684
119glutamate receptor signaling pathway (GO:0007215)2.74695241
120N-glycan processing (GO:0006491)2.73791547
121ionotropic glutamate receptor signaling pathway (GO:0035235)2.72989422
122synapse assembly (GO:0007416)2.71102331
123synaptic transmission, glutamatergic (GO:0035249)2.69196849
124cAMP catabolic process (GO:0006198)2.67734061
125regulation of action potential (GO:0098900)2.66838727
126serotonin metabolic process (GO:0042428)2.66406424
127negative chemotaxis (GO:0050919)2.65718534
128C4-dicarboxylate transport (GO:0015740)2.64523012
129photoreceptor cell maintenance (GO:0045494)2.64161329
130positive regulation of oligodendrocyte differentiation (GO:0048714)2.63890681
1314-hydroxyproline metabolic process (GO:0019471)2.63845462
132negative regulation of systemic arterial blood pressure (GO:0003085)2.63414504
133glycosphingolipid biosynthetic process (GO:0006688)2.62744506
134positive regulation of mitochondrial fission (GO:0090141)2.62245754
135negative regulation of transcription regulatory region DNA binding (GO:2000678)2.61875727
136dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.61316294
137neuronal action potential propagation (GO:0019227)2.60661422
138nucleobase-containing small molecule interconversion (GO:0015949)2.60632859
139deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.60453493
140positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.60439160
141sympathetic nervous system development (GO:0048485)2.57213213
142negative regulation of translation, ncRNA-mediated (GO:0040033)2.57060442
143regulation of translation, ncRNA-mediated (GO:0045974)2.57060442
144negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.57060442
145protein K11-linked deubiquitination (GO:0035871)2.56908346
146cilium morphogenesis (GO:0060271)2.56589406
147embryonic epithelial tube formation (GO:0001838)2.56578745
148epithelial cell maturation (GO:0002070)2.56243258
149viral protein processing (GO:0019082)2.56175583
150positive regulation of extracellular matrix organization (GO:1903055)2.56102287
151limb development (GO:0060173)2.55478643
152appendage development (GO:0048736)2.55478643
153protein-DNA complex disassembly (GO:0032986)2.55097163
154nucleosome disassembly (GO:0006337)2.55097163
155righting reflex (GO:0060013)2.54971628
156spinal cord development (GO:0021510)2.54620341
157peptidyl-histidine modification (GO:0018202)2.54535395
158membrane depolarization during action potential (GO:0086010)2.54086944
159central nervous system neuron axonogenesis (GO:0021955)2.53973683
160positive regulation of chondrocyte differentiation (GO:0032332)2.53748092
161cornea development in camera-type eye (GO:0061303)2.53433941
162positive regulation of receptor biosynthetic process (GO:0010870)2.52438894
163tryptophan metabolic process (GO:0006568)2.52193626
164detection of mechanical stimulus involved in sensory perception (GO:0050974)2.51900402
165indole-containing compound metabolic process (GO:0042430)2.50923240
166lymphoid progenitor cell differentiation (GO:0002320)2.50315230
167photoreceptor cell development (GO:0042461)2.49426894
168neuron recognition (GO:0008038)2.49227564
169deoxyribose phosphate biosynthetic process (GO:0046385)2.49184530
1702-deoxyribonucleotide biosynthetic process (GO:0009265)2.49184530
171midbrain development (GO:0030901)2.48903574
172protein polyglutamylation (GO:0018095)2.48179017
173membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.48033400
174regulation of nuclease activity (GO:0032069)2.47164606
175protein localization to cilium (GO:0061512)2.46996160
176spinal cord motor neuron differentiation (GO:0021522)2.46477680
177mechanosensory behavior (GO:0007638)2.45618454
178cilium or flagellum-dependent cell motility (GO:0001539)2.45517381
179dendritic spine morphogenesis (GO:0060997)2.45448664
180cyclic nucleotide catabolic process (GO:0009214)2.44907584
181cilium organization (GO:0044782)2.44444867
182DNA double-strand break processing (GO:0000729)2.44381260
183prostate gland growth (GO:0060736)2.44046106
184neuron-neuron synaptic transmission (GO:0007270)2.43376971
185epithelial tube formation (GO:0072175)2.42637163
186primary amino compound metabolic process (GO:1901160)2.42350027
187regulation of cilium movement (GO:0003352)2.41781749
188kynurenine metabolic process (GO:0070189)2.41021369
189negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.40597567
190dendrite morphogenesis (GO:0048813)2.39975746
191cilium assembly (GO:0042384)2.39313686
192regulation of development, heterochronic (GO:0040034)2.38142191
193cell proliferation in forebrain (GO:0021846)2.37483705

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human4.73878920
2E2F7_22180533_ChIP-Seq_HELA_Human4.47549738
3GATA1_22025678_ChIP-Seq_K562_Human4.05730241
4IGF1R_20145208_ChIP-Seq_DFB_Human3.72374779
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.34114931
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.29336216
7EZH2_22144423_ChIP-Seq_EOC_Human2.85663320
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.77407864
9SCL_19346495_ChIP-Seq_HPC-7_Human2.77342454
10HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.63105781
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.57006582
12CIITA_25753668_ChIP-Seq_RAJI_Human2.56825086
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.49839590
14TAF15_26573619_Chip-Seq_HEK293_Human2.46076150
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.42379582
16VDR_22108803_ChIP-Seq_LS180_Human2.31858288
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.27651329
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.26387042
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.25326758
20FUS_26573619_Chip-Seq_HEK293_Human2.20715044
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13290649
22P300_19829295_ChIP-Seq_ESCs_Human2.12485362
23EWS_26573619_Chip-Seq_HEK293_Human2.06441308
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.98715840
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.97560680
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.91696901
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91333602
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90830337
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.90785358
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89110774
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85248209
32SMAD4_21799915_ChIP-Seq_A2780_Human1.81953582
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81375365
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.80660848
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.79765428
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.79488748
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.76042015
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.75270940
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75218028
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72735781
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72007298
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.71472648
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71274570
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.67466923
45STAT3_23295773_ChIP-Seq_U87_Human1.65216760
46ER_23166858_ChIP-Seq_MCF-7_Human1.63829628
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63738473
48ZNF274_21170338_ChIP-Seq_K562_Hela1.63715470
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62448736
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62077621
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.61347316
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.60855447
53VDR_21846776_ChIP-Seq_THP-1_Human1.59837297
54RNF2_27304074_Chip-Seq_NSC_Mouse1.59177968
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.58187940
56MYC_22102868_ChIP-Seq_BL_Human1.57117340
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.53974655
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53960822
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53695481
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52714545
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51784518
62BCAT_22108803_ChIP-Seq_LS180_Human1.49579985
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.49486024
64AR_25329375_ChIP-Seq_VCAP_Human1.48340252
65TCF4_23295773_ChIP-Seq_U87_Human1.48281114
66AR_21572438_ChIP-Seq_LNCaP_Human1.47980520
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47379278
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46465196
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46406459
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46124789
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44436914
72CBP_20019798_ChIP-Seq_JUKART_Human1.44436914
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43608414
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43475477
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43475477
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.41243333
77SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.41198954
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39036674
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38689720
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.38040434
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36576887
82JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35382555
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35166131
84GBX2_23144817_ChIP-Seq_PC3_Human1.34973571
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33592746
86OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.32604005
87RUNX2_22187159_ChIP-Seq_PCA_Human1.31967254
88SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31418620
89RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31052436
90FOXP3_21729870_ChIP-Seq_TREG_Human1.29739121
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29704351
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.29096839
93EZH2_27294783_Chip-Seq_ESCs_Mouse1.28830376
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28186252
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28022920
96SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27958078
97VDR_24763502_ChIP-Seq_THP-1_Human1.27907031
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27439910
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.23921822
100MYC_18555785_ChIP-Seq_MESCs_Mouse1.23814924
101CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22530447
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21127501
103SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20883570
104TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19088403
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17907682
106SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17395996
107FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17339715
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17213384
109TCF4_22108803_ChIP-Seq_LS180_Human1.16444020
110BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16432632
111SOX2_21211035_ChIP-Seq_LN229_Gbm1.16129609
112DCP1A_22483619_ChIP-Seq_HELA_Human1.15250258
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.14871020
114NFE2_27457419_Chip-Seq_LIVER_Mouse1.14606258
115TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14530418
116SMAD4_21741376_ChIP-Seq_EPCs_Human1.14448693
117RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13279573
118TP53_16413492_ChIP-PET_HCT116_Human1.12462146
119YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12004559
120PRDM14_20953172_ChIP-Seq_ESCs_Human1.11941924
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11844276
122SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11679779
123CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11214156
124RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09639957
125ELK1_19687146_ChIP-ChIP_HELA_Human1.09487637
126IRF1_19129219_ChIP-ChIP_H3396_Human1.09343801
127JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08813308
128TAL1_26923725_Chip-Seq_HPCs_Mouse1.08304752
129P53_22387025_ChIP-Seq_ESCs_Mouse1.07640275
130TTF2_22483619_ChIP-Seq_HELA_Human1.07490074
131KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07226402
132KDM2B_26808549_Chip-Seq_REH_Human1.07122400
133RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07091951
134FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.06499908
135XRN2_22483619_ChIP-Seq_HELA_Human1.05869310
136TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05597959
137LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05293481
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05147245
139CBX2_27304074_Chip-Seq_ESCs_Mouse1.04848349
140SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04403418
141ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04063477
142CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04002732
143E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03995332
144SPI1_23547873_ChIP-Seq_NB4_Human1.03038467
145RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02308149
146NANOG_19829295_ChIP-Seq_ESCs_Human1.02272761
147SOX2_19829295_ChIP-Seq_ESCs_Human1.02272761
148HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02133797
149JUN_21703547_ChIP-Seq_K562_Human1.01674180
150STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01347309
151ARNT_22903824_ChIP-Seq_MCF-7_Human1.01174578
152GABP_19822575_ChIP-Seq_HepG2_Human1.00335841
153RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99590539
154EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99590539
155ELK1_22589737_ChIP-Seq_MCF10A_Human0.94832284
156MYC_18358816_ChIP-ChIP_MESCs_Mouse0.94385251
157REST_18959480_ChIP-ChIP_MESCs_Mouse0.93646776
158LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93514789
159RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90336709
160LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90072854
161EST1_17652178_ChIP-ChIP_JURKAT_Human0.89230534
162THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89111039
163RNF2_27304074_Chip-Seq_ESCs_Mouse0.88904186
164CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88371902
165EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86494050
166CTBP1_25329375_ChIP-Seq_LNCAP_Human0.85810418
167TP53_22573176_ChIP-Seq_HFKS_Human0.85746018
168POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85240045
169REST_21632747_ChIP-Seq_MESCs_Mouse0.84712306
170ETS1_20019798_ChIP-Seq_JURKAT_Human0.83929229
171SRF_21415370_ChIP-Seq_HL-1_Mouse0.83672067
172ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82870265
173HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.81609834
174BRD4_27068464_Chip-Seq_AML-cells_Mouse0.81271570
175ERG_20517297_ChIP-Seq_VCAP_Human0.79478429
176PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79009490

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism4.90712757
2MP0005503_abnormal_tendon_morphology4.50701168
3MP0000566_synostosis4.37468228
4MP0003283_abnormal_digestive_organ3.63848564
5MP0002282_abnormal_trachea_morphology3.38589382
6MP0002933_joint_inflammation2.99260477
7MP0000569_abnormal_digit_pigmentation2.81471299
8MP0003880_abnormal_central_pattern2.75408634
9MP0002089_abnormal_postnatal_growth/wei2.69027342
10MP0006054_spinal_hemorrhage2.56311820
11MP0001968_abnormal_touch/_nociception2.55468257
12MP0005220_abnormal_exocrine_pancreas2.49056585
13MP0002736_abnormal_nociception_after2.48932936
14MP0008438_abnormal_cutaneous_collagen2.45547564
15MP0001984_abnormal_olfaction2.43010716
16MP0002909_abnormal_adrenal_gland2.18831862
17MP0004134_abnormal_chest_morphology2.09892123
18MP0002234_abnormal_pharynx_morphology2.08768066
19MP0000778_abnormal_nervous_system2.08185404
20MP0002272_abnormal_nervous_system2.07506254
21MP0009745_abnormal_behavioral_response2.06478715
22MP0009046_muscle_twitch2.01958214
23MP0010386_abnormal_urinary_bladder2.01938457
24MP0000163_abnormal_cartilage_morphology2.01381142
25MP0005551_abnormal_eye_electrophysiolog1.99844023
26MP0009780_abnormal_chondrocyte_physiolo1.98045884
27MP0003123_paternal_imprinting1.92803997
28MP0000678_abnormal_parathyroid_gland1.92732330
29MP0003436_decreased_susceptibility_to1.92294573
30MP0003635_abnormal_synaptic_transmissio1.83886300
31MP0008961_abnormal_basal_metabolism1.83388155
32MP0008877_abnormal_DNA_methylation1.82554241
33MP0001486_abnormal_startle_reflex1.78112709
34MP0005646_abnormal_pituitary_gland1.75627820
35MP0005390_skeleton_phenotype1.74137277
36MP0001501_abnormal_sleep_pattern1.73034958
37MP0001533_abnormal_skeleton_physiology1.72007685
38MP0005253_abnormal_eye_physiology1.70726575
39MP0002396_abnormal_hematopoietic_system1.70603167
40MP0002572_abnormal_emotion/affect_behav1.68386658
41MP0002735_abnormal_chemical_nociception1.66213332
42MP0002102_abnormal_ear_morphology1.64409732
43MP0009250_abnormal_appendicular_skeleto1.63678803
44MP0001944_abnormal_pancreas_morphology1.62956372
45MP0003195_calcinosis1.62697980
46MP0002653_abnormal_ependyma_morphology1.61495155
47MP0002113_abnormal_skeleton_development1.60993621
48MP0004270_analgesia1.60882316
49MP0001485_abnormal_pinna_reflex1.60374751
50MP0004885_abnormal_endolymph1.60306579
51MP0002734_abnormal_mechanical_nocicepti1.60134781
52MP0002064_seizures1.59851573
53MP0005508_abnormal_skeleton_morphology1.58864854
54MP0001529_abnormal_vocalization1.58431835
55MP0002557_abnormal_social/conspecific_i1.56507372
56MP0002751_abnormal_autonomic_nervous1.56215744
57MP0002115_abnormal_skeleton_extremities1.53537050
58MP0003136_yellow_coat_color1.52986634
59MP0002638_abnormal_pupillary_reflex1.52622136
60MP0001270_distended_abdomen1.46269312
61MP0009384_cardiac_valve_regurgitation1.42407956
62MP0002938_white_spotting1.41596568
63MP0006072_abnormal_retinal_apoptosis1.40259555
64MP0000490_abnormal_crypts_of1.40227291
65MP0000462_abnormal_digestive_system1.40092735
66MP0000631_abnormal_neuroendocrine_gland1.37504529
67MP0005394_taste/olfaction_phenotype1.37043216
68MP0005499_abnormal_olfactory_system1.37043216
69MP0004924_abnormal_behavior1.35774184
70MP0005386_behavior/neurological_phenoty1.35774184
71MP0001663_abnormal_digestive_system1.35571775
72MP0006276_abnormal_autonomic_nervous1.35528144
73MP0008789_abnormal_olfactory_epithelium1.34550556
74MP0001970_abnormal_pain_threshold1.32997432
75MP0004142_abnormal_muscle_tone1.32544308
76MP0005423_abnormal_somatic_nervous1.32424300
77MP0002067_abnormal_sensory_capabilities1.31602791
78MP0002896_abnormal_bone_mineralization1.31540861
79MP0003121_genomic_imprinting1.29884460
80MP0003959_abnormal_lean_body1.28646472
81MP0003937_abnormal_limbs/digits/tail_de1.28156854
82MP0000681_abnormal_thyroid_gland1.27818711
83MP0005381_digestive/alimentary_phenotyp1.27512120
84MP0003122_maternal_imprinting1.26955081
85MP0003279_aneurysm1.26805898
86MP0000427_abnormal_hair_cycle1.24421970
87MP0002733_abnormal_thermal_nociception1.23502561
88MP0000538_abnormal_urinary_bladder1.21530085
89MP0003795_abnormal_bone_structure1.20865649
90MP0003011_delayed_dark_adaptation1.20331620
91MP0008872_abnormal_physiological_respon1.20053189
92MP0002928_abnormal_bile_duct1.17433179
93MP0002160_abnormal_reproductive_system1.16711428
94MP0003693_abnormal_embryo_hatching1.16644468
95MP0001502_abnormal_circadian_rhythm1.13871912
96MP0002822_catalepsy1.12882194
97MP0001299_abnormal_eye_distance/1.12732306
98MP0002752_abnormal_somatic_nervous1.10202220
99MP0000049_abnormal_middle_ear1.09530854
100MP0002882_abnormal_neuron_morphology1.09510686
101MP0000955_abnormal_spinal_cord1.09381197
102MP0002109_abnormal_limb_morphology1.08689654
103MP0005275_abnormal_skin_tensile1.06155546
104MP0002693_abnormal_pancreas_physiology1.06013983
105MP0004808_abnormal_hematopoietic_stem1.05453588
106MP0005195_abnormal_posterior_eye1.03191023
107MP0005389_reproductive_system_phenotype1.02779913
108MP0001873_stomach_inflammation1.02555122
109MP0005174_abnormal_tail_pigmentation1.01057097
110MP0005645_abnormal_hypothalamus_physiol1.00701461
111MP0003172_abnormal_lysosome_physiology0.99984092
112MP0003656_abnormal_erythrocyte_physiolo0.99633995
113MP0010030_abnormal_orbit_morphology0.99365346
114MP0002837_dystrophic_cardiac_calcinosis0.99188673
115MP0003938_abnormal_ear_development0.99019143
116MP0002233_abnormal_nose_morphology0.98212887
117MP0002116_abnormal_craniofacial_bone0.97644101
118MP0001963_abnormal_hearing_physiology0.96334426
119MP0004782_abnormal_surfactant_physiolog0.95966784
120MP0001919_abnormal_reproductive_system0.94486015
121MP0001177_atelectasis0.94455067
122MP0005171_absent_coat_pigmentation0.93481771
123MP0002184_abnormal_innervation0.92430000
124MP0002152_abnormal_brain_morphology0.92228996
125MP0001293_anophthalmia0.91900104
126MP0009053_abnormal_anal_canal0.91822463
127MP0004742_abnormal_vestibular_system0.91764814
128MP0005391_vision/eye_phenotype0.88090087
129MP0003137_abnormal_impulse_conducting0.87432254
130MP0002932_abnormal_joint_morphology0.87152957
131MP0004859_abnormal_synaptic_plasticity0.85681070
132MP0003861_abnormal_nervous_system0.85108538
133MP0003787_abnormal_imprinting0.85030630
134MP0003755_abnormal_palate_morphology0.84802814
135MP0001440_abnormal_grooming_behavior0.84276499
136MP0003890_abnormal_embryonic-extraembry0.84155566
137MP0000372_irregular_coat_pigmentation0.83095057
138MP0005365_abnormal_bile_salt0.82973948
139MP0003718_maternal_effect0.82586965
140MP0000465_gastrointestinal_hemorrhage0.82556915
141MP0003868_abnormal_feces_composition0.82086617
142MP0004133_heterotaxia0.82054162
143MP0002877_abnormal_melanocyte_morpholog0.81105037
144MP0003646_muscle_fatigue0.80308756
145MP0000858_altered_metastatic_potential0.79773439
146MP0000383_abnormal_hair_follicle0.78989147
147MP0001188_hyperpigmentation0.78536237
148MP0003119_abnormal_digestive_system0.76569053
149MP0005084_abnormal_gallbladder_morpholo0.75958696
150MP0000026_abnormal_inner_ear0.72900134
151MP0003385_abnormal_body_wall0.69866838
152MP0002876_abnormal_thyroid_physiology0.68896667
153MP0002111_abnormal_tail_morphology0.67992809
154MP0002108_abnormal_muscle_morphology0.67528789
155MP0004264_abnormal_extraembryonic_tissu0.66293273
156MP0001958_emphysema0.63882270
157MP0001666_abnormal_nutrient_absorption0.61735519
158MP0006292_abnormal_olfactory_placode0.60880273
159MP0003942_abnormal_urinary_system0.59961194
160MP0002114_abnormal_axial_skeleton0.58831363
161MP0003091_abnormal_cell_migration0.58744940
162MP0005187_abnormal_penis_morphology0.56798633
163MP0002063_abnormal_learning/memory/cond0.55872576
164MP0008995_early_reproductive_senescence0.54447503
165MP0001986_abnormal_taste_sensitivity0.54311301
166MP0000358_abnormal_cell_content/0.52869773
167MP0002060_abnormal_skin_morphology0.52805406
168MP0000343_altered_response_to0.52763785
169MP0003763_abnormal_thymus_physiology0.52418084

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)6.88001180
2Irregular epiphyses (HP:0010582)6.73439718
3Vitreoretinal degeneration (HP:0000655)5.54364966
4Flat capital femoral epiphysis (HP:0003370)4.37797994
5Hypoplastic ischia (HP:0003175)4.34234497
6Cupped ribs (HP:0000887)4.32849962
7Small epiphyses (HP:0010585)4.20917179
8Abnormal tarsal ossification (HP:0008369)4.03125617
9Pancreatic cysts (HP:0001737)3.90699746
10Abnormal foot bone ossification (HP:0010675)3.76457295
11Mild short stature (HP:0003502)3.74236797
12Flattened epiphyses (HP:0003071)3.73899551
13Disproportionate short-trunk short stature (HP:0003521)3.71950731
14Genu varum (HP:0002970)3.70269475
15Neonatal short-limb short stature (HP:0008921)3.65404041
16Abnormality of the ischium (HP:0003174)3.63488168
17True hermaphroditism (HP:0010459)3.62517294
18Beaking of vertebral bodies (HP:0004568)3.61935689
19Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.50236916
20Pancreatic fibrosis (HP:0100732)3.49911316
21Hyperventilation (HP:0002883)3.49224091
22Flat acetabular roof (HP:0003180)3.48138449
23Abnormality of the vertebral endplates (HP:0005106)3.37086818
24Arthropathy (HP:0003040)3.36116289
25Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.35007922
26Abnormality of femoral epiphyses (HP:0006499)3.35007922
27Cervical subluxation (HP:0003308)3.32939483
28Delayed epiphyseal ossification (HP:0002663)3.31752770
29Genetic anticipation (HP:0003743)3.23785726
30Osteoarthritis (HP:0002758)3.22846532
31Progressive cerebellar ataxia (HP:0002073)3.18585405
32Metaphyseal cupping (HP:0003021)3.17667538
33Thoracolumbar scoliosis (HP:0002944)3.12635482
34Medial flaring of the eyebrow (HP:0010747)3.09568216
35Abnormality of midbrain morphology (HP:0002418)3.06682928
36Molar tooth sign on MRI (HP:0002419)3.06682928
37Nephronophthisis (HP:0000090)3.05669097
38Abnormality of the epiphysis of the femoral head (HP:0010574)3.02933920
39Platyspondyly (HP:0000926)2.94072763
40Absent epiphyses (HP:0010577)2.92074992
41Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.92074992
42Irregular vertebral endplates (HP:0003301)2.91167371
43Gaze-evoked nystagmus (HP:0000640)2.87247410
44Long clavicles (HP:0000890)2.85530009
45Gait imbalance (HP:0002141)2.84279861
46Metaphyseal irregularity (HP:0003025)2.82447134
47Mesomelia (HP:0003027)2.81448288
48Type II lissencephaly (HP:0007260)2.79782037
49Protuberant abdomen (HP:0001538)2.79573653
50Thrombocytosis (HP:0001894)2.79236147
51Abnormality of the femoral head (HP:0003368)2.76996812
52Abnormality of the odontoid process (HP:0003310)2.76352463
53Short femoral neck (HP:0100864)2.74442990
54Pendular nystagmus (HP:0012043)2.73883105
55Abnormality of the renal medulla (HP:0100957)2.70602062
56Chronic hepatic failure (HP:0100626)2.70569656
57Abnormality of the renal cortex (HP:0011035)2.70277753
58Keratoconus (HP:0000563)2.69466329
59Increased corneal curvature (HP:0100692)2.69466329
60Ovoid vertebral bodies (HP:0003300)2.64792576
61Congenital primary aphakia (HP:0007707)2.64155085
62Abnormality of the intervertebral disk (HP:0005108)2.62195473
63Abolished electroretinogram (ERG) (HP:0000550)2.60645087
64Focal motor seizures (HP:0011153)2.59124206
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.58603011
66Abnormal protein N-linked glycosylation (HP:0012347)2.58603011
67Abnormal protein glycosylation (HP:0012346)2.58603011
68Abnormal glycosylation (HP:0012345)2.58603011
69Aplasia/Hypoplasia of the tibia (HP:0005772)2.58487548
70Severe short stature (HP:0003510)2.58401658
71Coxa vara (HP:0002812)2.57970726
72Absent speech (HP:0001344)2.57889076
73Limited elbow extension (HP:0001377)2.56444698
74Genital tract atresia (HP:0001827)2.55473829
75Congenital stationary night blindness (HP:0007642)2.54148683
76Broad-based gait (HP:0002136)2.52348292
77Nephrogenic diabetes insipidus (HP:0009806)2.52209551
78Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.47985050
79Vaginal atresia (HP:0000148)2.47786498
80Lumbar hyperlordosis (HP:0002938)2.47750779
81Metaphyseal dysplasia (HP:0100255)2.46417811
82Exostoses (HP:0100777)2.45602272
83Febrile seizures (HP:0002373)2.45117890
84Oligodactyly (hands) (HP:0001180)2.40886636
85Joint stiffness (HP:0001387)2.39313009
86Lissencephaly (HP:0001339)2.38732488
87Intestinal atresia (HP:0011100)2.38663899
88Abnormality of the pubic bones (HP:0003172)2.36784765
89Hypoplasia of the odontoid process (HP:0003311)2.35958413
90Absent frontal sinuses (HP:0002688)2.35911404
91Cystic liver disease (HP:0006706)2.33137137
92Focal seizures (HP:0007359)2.30218039
93Drooling (HP:0002307)2.30179455
94Thyroid-stimulating hormone excess (HP:0002925)2.29777914
95Cerebellar dysplasia (HP:0007033)2.29495679
96Degeneration of anterior horn cells (HP:0002398)2.28253282
97Abnormality of the anterior horn cell (HP:0006802)2.28253282
98Abnormality of the proximal phalanges of the hand (HP:0009834)2.26452075
99Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.25192935
100Attenuation of retinal blood vessels (HP:0007843)2.25065385
101Progressive inability to walk (HP:0002505)2.23000212
102Coxa valga (HP:0002673)2.22954748
103Inability to walk (HP:0002540)2.20831666
104Enlarged epiphyses (HP:0010580)2.20653594
105Optic nerve hypoplasia (HP:0000609)2.19589627
106Retinal dysplasia (HP:0007973)2.17864272
107Spinal cord compression (HP:0002176)2.16270001
108Hemiparesis (HP:0001269)2.15881159
109Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.15614871
110Hypothermia (HP:0002045)2.15379394
111Sclerocornea (HP:0000647)2.13105387
112Broad palm (HP:0001169)2.12846320
113Cupped ear (HP:0000378)2.11933037
114Renal cortical cysts (HP:0000803)2.11721756
115Postaxial hand polydactyly (HP:0001162)2.09606093
116Aplasia/Hypoplasia of the tongue (HP:0010295)2.08591857
117Fibular hypoplasia (HP:0003038)2.08559944
118Aplastic anemia (HP:0001915)2.08500762
119Type I transferrin isoform profile (HP:0003642)2.08114477
120Reduced antithrombin III activity (HP:0001976)2.07359215
121Rhizomelia (HP:0008905)2.07263306
122Poor coordination (HP:0002370)2.05568664
123Congenital sensorineural hearing impairment (HP:0008527)2.04586671
124Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.04046247
125Vertebral hypoplasia (HP:0008417)2.04046247
126Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.03780965
127Excessive salivation (HP:0003781)2.03667354
128Abnormality of the labia minora (HP:0012880)2.03389756
129Pachygyria (HP:0001302)2.02772648
130Short tibia (HP:0005736)2.01979398
131Tubular atrophy (HP:0000092)2.01302327
132Postaxial foot polydactyly (HP:0001830)1.99033997
133Ulnar deviation of the wrist (HP:0003049)1.98895589
134Bony spicule pigmentary retinopathy (HP:0007737)1.97926342
135Aplasia/hypoplasia of the femur (HP:0005613)1.97610219
136Chorioretinal atrophy (HP:0000533)1.97354726
137Protruding tongue (HP:0010808)1.96319272
138Anencephaly (HP:0002323)1.95932267
139Abnormality of the lumbar spine (HP:0100712)1.95738690
140Hypoplastic ilia (HP:0000946)1.93073479
141Micromelia (HP:0002983)1.92454343
142Tented upper lip vermilion (HP:0010804)1.91684329
143Decreased central vision (HP:0007663)1.91155068
144Small hand (HP:0200055)1.91046170
145Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.90153248
146Genu valgum (HP:0002857)1.89219109
14711 pairs of ribs (HP:0000878)1.89075236
148Barrel-shaped chest (HP:0001552)1.89039737
149Limb dystonia (HP:0002451)1.88026381
150Specific learning disability (HP:0001328)1.87989820
151Abnormal vertebral ossification (HP:0100569)1.87696608
152Abnormality of the phalanges of the 2nd finger (HP:0009541)1.86991480
153Polydipsia (HP:0001959)1.86605962
154Abnormal drinking behavior (HP:0030082)1.86605962
155Short foot (HP:0001773)1.86468220
156Carpal bone hypoplasia (HP:0001498)1.85826781
157Growth hormone deficiency (HP:0000824)1.85332207
158Congenital hepatic fibrosis (HP:0002612)1.84345695
159Morphological abnormality of the middle ear (HP:0008609)1.83751186
160Abnormal biliary tract physiology (HP:0012439)1.83453713
161Bile duct proliferation (HP:0001408)1.83453713
162Dialeptic seizures (HP:0011146)1.83261190
163Radial bowing (HP:0002986)1.83140675
164Colon cancer (HP:0003003)1.81919266
165Stenosis of the external auditory canal (HP:0000402)1.80578542
166Thickened calvaria (HP:0002684)1.80268201
167Atonic seizures (HP:0010819)1.79626994
168Male pseudohermaphroditism (HP:0000037)1.79514011
169Methylmalonic acidemia (HP:0002912)1.78546516
170Shawl scrotum (HP:0000049)1.78307892
171Papilledema (HP:0001085)1.78200508
172Anophthalmia (HP:0000528)1.77924548
173Spinal canal stenosis (HP:0003416)1.77743318
174Renal hypoplasia (HP:0000089)1.77567402
175Agitation (HP:0000713)1.77479372
176Decreased skull ossification (HP:0004331)1.77465525
177Thoracic kyphosis (HP:0002942)1.77241000
178Abdominal distention (HP:0003270)1.76598879
179Fair hair (HP:0002286)1.76542814
180Waddling gait (HP:0002515)1.76458754
181Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.75692406
182Flared metaphyses (HP:0003015)1.75549138
183Broad phalanx (HP:0006009)1.75470544
184Ectopia lentis (HP:0001083)1.75151488
185Volvulus (HP:0002580)1.73502329
186Glossoptosis (HP:0000162)1.73089168
187Long toe (HP:0010511)1.72892157
188Preaxial hand polydactyly (HP:0001177)1.72632326
189Cutaneous finger syndactyly (HP:0010554)1.72057778
190Action tremor (HP:0002345)1.71325483
191Aplasia/hypoplasia of the uterus (HP:0008684)1.70082577
192Narrow forehead (HP:0000341)1.69752797
193Severe muscular hypotonia (HP:0006829)1.66556317
194Hyperglycinemia (HP:0002154)1.65845682
195Polyphagia (HP:0002591)1.64850732
196Patellar aplasia (HP:0006443)1.62516115
197Aplasia/Hypoplasia of the patella (HP:0006498)1.61269172
198Furrowed tongue (HP:0000221)1.60775743

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.23913298
2TAOK24.59097536
3INSRR4.28800652
4CASK3.30683861
5ERBB33.13768974
6MAP3K43.03923663
7FLT32.82556356
8SIK32.80094355
9WNK32.73659504
10IRAK42.59212747
11MAP3K32.41666397
12STK162.31296169
13BCR2.28148103
14PASK2.25425714
15TAOK32.22591747
16MAP4K22.15897996
17EPHA32.11832565
18MAP2K72.04332649
19TESK12.00968130
20EIF2AK32.00892449
21ERN12.00371857
22TRIM281.97221213
23TGFBR11.91936637
24GRK11.91118421
25EPHA41.85396312
26DDR21.85133406
27LIMK11.84517333
28STK38L1.83853228
29MARK11.75936647
30BRSK21.75398217
31PINK11.75351889
32TNIK1.71914023
33MAP2K61.66531352
34EPHB21.61497175
35CSNK1G21.54703637
36CAMKK21.51948212
37NME11.41664304
38CSNK1A1L1.40989067
39BTK1.40872161
40ZAK1.38692521
41KIT1.38166512
42NUAK11.36276223
43PLK21.35582694
44CSNK1G31.35259772
45EIF2AK11.35113298
46PRKCE1.32784108
47KSR11.32529538
48CSNK1G11.32270120
49TEC1.31638286
50MAPK131.29091856
51LMTK21.21189444
52NTRK31.20430585
53TRPM71.14216748
54BRSK11.13338093
55PRKCG1.11201137
56NLK1.11008280
57MAP2K31.10342888
58PAK31.08739895
59STK391.08569592
60RPS6KA41.05564824
61PRKD31.04238718
62VRK11.03756619
63EEF2K1.03401801
64PIK3CG1.00890294
65PNCK0.99616853
66DAPK20.97522492
67BMPR1B0.96400132
68MYLK0.96245720
69MKNK20.96232915
70DYRK1A0.95457335
71MKNK10.94951756
72OXSR10.94175362
73DYRK20.92990839
74WNK40.92646480
75NTRK20.91653923
76DYRK30.89662250
77FGFR10.88695095
78DAPK10.86209405
79RPS6KA60.85254329
80CDK190.83675363
81MAPK40.82660658
82BCKDK0.81883303
83TNK20.81048343
84ITK0.80100536
85PRPF4B0.79833235
86CAMK2A0.78545090
87SGK20.77650564
88CDK80.75724429
89RPS6KA20.73295965
90MAP2K40.73083221
91ACVR1B0.72668257
92UHMK10.70800790
93SGK2230.69557327
94SGK4940.69557327
95RPS6KL10.69320512
96RPS6KC10.69320512
97CAMK40.69041039
98TAOK10.68968204
99CSF1R0.68737542
100PLK30.67254877
101MAP3K50.66009046
102MAPKAPK30.65798258
103RPS6KB10.65220627
104ADRBK20.65062565
105STK240.63128237
106ZAP700.62326802
107FGFR40.62076656
108DYRK1B0.61111217
109PRKCZ0.58077321
110CSNK1D0.55947482
111PAK60.55369474
112SRPK10.54060048
113ADRBK10.52457665
114CDK70.52076482
115STK380.51355539
116FER0.51295458
117PRKG20.51288934
118JAK30.51248498
119PDGFRA0.50537688
120WEE10.49795874
121EIF2AK20.49571100
122CCNB10.49043250
123TESK20.48605389
124FES0.47704394
125RPS6KA50.47331747
126CDK50.47330265
127PLK40.46657716
128ATR0.45789321
129PRKACA0.45408203
130TXK0.44610829
131PHKG20.44223620
132PHKG10.44223620
133CSNK1A10.43559512
134MINK10.43307390
135SIK10.43156060
136AURKB0.43037197
137CAMK2B0.42756685
138SYK0.42464965
139PKN20.42356679
140AKT30.41376696
141ERBB20.40427268
142IRAK30.40041952
143STK110.39769367
144PKN10.39724211
145PRKAA10.39265518
146MAPKAPK50.38970861
147PTK2B0.38839648
148LATS10.38492474
149SIK20.35888776
150PRKCD0.35693455
151TTN0.35273982
152ROCK10.34995091
153CHUK0.34576728
154CDK90.34236797
155NEK10.33766483
156CAMKK10.33619866
157YES10.33260145
158PRKG10.33246295
159FGFR20.33215350
160PRKACB0.32360549
161STK30.31760575
162GRK70.31104382
163CDK30.30635975
164PDK20.29471667
165ATM0.28283066

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.66788437
2Protein export_Homo sapiens_hsa030604.27230938
3N-Glycan biosynthesis_Homo sapiens_hsa005103.70554700
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.45293387
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.37922810
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.80241577
7Phototransduction_Homo sapiens_hsa047442.70392900
8Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.44292988
9DNA replication_Homo sapiens_hsa030302.25595533
10Butanoate metabolism_Homo sapiens_hsa006502.24109524
11Sulfur metabolism_Homo sapiens_hsa009202.09634664
12Protein digestion and absorption_Homo sapiens_hsa049742.00182975
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.98575985
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.92295196
15Base excision repair_Homo sapiens_hsa034101.88075524
16Glutamatergic synapse_Homo sapiens_hsa047241.87868510
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87526070
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.76778351
19Nitrogen metabolism_Homo sapiens_hsa009101.70494704
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68174786
21Galactose metabolism_Homo sapiens_hsa000521.68169961
22Starch and sucrose metabolism_Homo sapiens_hsa005001.66652028
23Linoleic acid metabolism_Homo sapiens_hsa005911.63506134
24Olfactory transduction_Homo sapiens_hsa047401.60954124
25Nicotine addiction_Homo sapiens_hsa050331.58737521
26Other glycan degradation_Homo sapiens_hsa005111.56916942
27Steroid biosynthesis_Homo sapiens_hsa001001.50794586
28Vibrio cholerae infection_Homo sapiens_hsa051101.47881652
29Basal transcription factors_Homo sapiens_hsa030221.44970592
30Fanconi anemia pathway_Homo sapiens_hsa034601.43986380
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.40488225
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.39423222
33Thyroid hormone synthesis_Homo sapiens_hsa049181.34587054
34Propanoate metabolism_Homo sapiens_hsa006401.32582846
35Ether lipid metabolism_Homo sapiens_hsa005651.28522168
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.27900946
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26997073
38Serotonergic synapse_Homo sapiens_hsa047261.23745110
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21964843
40Ovarian steroidogenesis_Homo sapiens_hsa049131.20200314
41Circadian rhythm_Homo sapiens_hsa047101.19202248
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.18141452
43Tryptophan metabolism_Homo sapiens_hsa003801.17291159
44Mismatch repair_Homo sapiens_hsa034301.15202232
45Long-term depression_Homo sapiens_hsa047301.14942648
46Phagosome_Homo sapiens_hsa041451.13544033
47ABC transporters_Homo sapiens_hsa020101.13260985
48Hedgehog signaling pathway_Homo sapiens_hsa043401.12669055
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12478412
50Cocaine addiction_Homo sapiens_hsa050301.10145820
51Non-homologous end-joining_Homo sapiens_hsa034501.09835939
52ECM-receptor interaction_Homo sapiens_hsa045121.08834162
53Salivary secretion_Homo sapiens_hsa049701.06707921
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06421749
55Insulin secretion_Homo sapiens_hsa049111.05479674
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04322241
57Homologous recombination_Homo sapiens_hsa034401.03459031
58beta-Alanine metabolism_Homo sapiens_hsa004101.02733098
59Notch signaling pathway_Homo sapiens_hsa043301.01468267
60Cell cycle_Homo sapiens_hsa041101.01250074
61RNA degradation_Homo sapiens_hsa030180.99900026
62Dorso-ventral axis formation_Homo sapiens_hsa043200.99872392
63Selenocompound metabolism_Homo sapiens_hsa004500.96889747
64Spliceosome_Homo sapiens_hsa030400.96348672
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96348332
66Calcium signaling pathway_Homo sapiens_hsa040200.94568036
67Lysine degradation_Homo sapiens_hsa003100.94503501
68Leishmaniasis_Homo sapiens_hsa051400.93268980
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93062654
70Oxidative phosphorylation_Homo sapiens_hsa001900.91582633
71Regulation of autophagy_Homo sapiens_hsa041400.89879920
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87992548
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85063180
74Legionellosis_Homo sapiens_hsa051340.85020310
75Peroxisome_Homo sapiens_hsa041460.84594593
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.84487105
77Type II diabetes mellitus_Homo sapiens_hsa049300.84352221
78Hippo signaling pathway_Homo sapiens_hsa043900.82920467
79cAMP signaling pathway_Homo sapiens_hsa040240.79193995
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78877623
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78332205
82Chemical carcinogenesis_Homo sapiens_hsa052040.78036784
83Shigellosis_Homo sapiens_hsa051310.76841199
84Chronic myeloid leukemia_Homo sapiens_hsa052200.76788878
85Cardiac muscle contraction_Homo sapiens_hsa042600.76400395
86Nucleotide excision repair_Homo sapiens_hsa034200.75038865
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74657600
88Gastric acid secretion_Homo sapiens_hsa049710.74629015
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72132861
90Parkinsons disease_Homo sapiens_hsa050120.71929510
91Renin secretion_Homo sapiens_hsa049240.69719781
92RNA polymerase_Homo sapiens_hsa030200.69627912
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66364142
94Pyrimidine metabolism_Homo sapiens_hsa002400.66230644
95Retinol metabolism_Homo sapiens_hsa008300.65397956
96Glycerolipid metabolism_Homo sapiens_hsa005610.65275805
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63862112
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63566829
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63321998
100Histidine metabolism_Homo sapiens_hsa003400.62522233
101Sphingolipid metabolism_Homo sapiens_hsa006000.62130624
102Synaptic vesicle cycle_Homo sapiens_hsa047210.61859859
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.61055663
104Wnt signaling pathway_Homo sapiens_hsa043100.59831656
105One carbon pool by folate_Homo sapiens_hsa006700.59668045
106Circadian entrainment_Homo sapiens_hsa047130.59605172
107Dopaminergic synapse_Homo sapiens_hsa047280.58824497
108Caffeine metabolism_Homo sapiens_hsa002320.58600266
109TGF-beta signaling pathway_Homo sapiens_hsa043500.57818111
110Huntingtons disease_Homo sapiens_hsa050160.57056199
111Fatty acid biosynthesis_Homo sapiens_hsa000610.56343179
112Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56287576
113Focal adhesion_Homo sapiens_hsa045100.56005926
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53907248
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53738405
116Taste transduction_Homo sapiens_hsa047420.53597432
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53500987
118Collecting duct acid secretion_Homo sapiens_hsa049660.53045970
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52838862
120mTOR signaling pathway_Homo sapiens_hsa041500.52754845
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52574735
122Alcoholism_Homo sapiens_hsa050340.52495504
123Pentose phosphate pathway_Homo sapiens_hsa000300.52069893
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51476265
125Pancreatic cancer_Homo sapiens_hsa052120.51218736
126Hepatitis B_Homo sapiens_hsa051610.51134094
127Colorectal cancer_Homo sapiens_hsa052100.50887901
128Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50533920
129Ribosome_Homo sapiens_hsa030100.50182964
130Ras signaling pathway_Homo sapiens_hsa040140.49550894
131Alzheimers disease_Homo sapiens_hsa050100.49424223
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49138909
133Oocyte meiosis_Homo sapiens_hsa041140.48908194
134Morphine addiction_Homo sapiens_hsa050320.47693259
135Basal cell carcinoma_Homo sapiens_hsa052170.47173741
136Amphetamine addiction_Homo sapiens_hsa050310.46575816
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45640158
138Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43900485
139Gap junction_Homo sapiens_hsa045400.43680578
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.43418421
141Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43071163
142Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42087889
143Fructose and mannose metabolism_Homo sapiens_hsa000510.41819450
144Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40991420
145Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40820191
146Proteoglycans in cancer_Homo sapiens_hsa052050.40548070
147Platelet activation_Homo sapiens_hsa046110.40047884
148Purine metabolism_Homo sapiens_hsa002300.39851050
149Arachidonic acid metabolism_Homo sapiens_hsa005900.38997407
150Fatty acid metabolism_Homo sapiens_hsa012120.38479026
151PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38389601
152Renin-angiotensin system_Homo sapiens_hsa046140.38329090
153Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38063634
154Pancreatic secretion_Homo sapiens_hsa049720.37896859
155HTLV-I infection_Homo sapiens_hsa051660.37202616
156Cholinergic synapse_Homo sapiens_hsa047250.36937512
157Insulin resistance_Homo sapiens_hsa049310.35551409
158Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35135048
159Glucagon signaling pathway_Homo sapiens_hsa049220.33529049
160Oxytocin signaling pathway_Homo sapiens_hsa049210.33095370
161Acute myeloid leukemia_Homo sapiens_hsa052210.31840958
162Insulin signaling pathway_Homo sapiens_hsa049100.31143989
163HIF-1 signaling pathway_Homo sapiens_hsa040660.31017952
164p53 signaling pathway_Homo sapiens_hsa041150.30409098
165Axon guidance_Homo sapiens_hsa043600.29426503
166Thyroid cancer_Homo sapiens_hsa052160.29421290
167Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28179190
168Lysosome_Homo sapiens_hsa041420.27624884
169Long-term potentiation_Homo sapiens_hsa047200.25685779
170GABAergic synapse_Homo sapiens_hsa047270.25616993
171Bladder cancer_Homo sapiens_hsa052190.25535999
172Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25469184
173RNA transport_Homo sapiens_hsa030130.25071889

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »