PXMP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.30810715
2L-phenylalanine catabolic process (GO:0006559)7.30810715
3L-phenylalanine metabolic process (GO:0006558)7.12210148
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.12210148
5aromatic amino acid family catabolic process (GO:0009074)6.55778515
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.22014488
7tryptophan catabolic process (GO:0006569)5.92076469
8indole-containing compound catabolic process (GO:0042436)5.92076469
9indolalkylamine catabolic process (GO:0046218)5.92076469
10kynurenine metabolic process (GO:0070189)5.89472065
11glyoxylate metabolic process (GO:0046487)5.86867775
12deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.71128023
13bile acid biosynthetic process (GO:0006699)5.63640570
14ribosomal small subunit biogenesis (GO:0042274)5.60245238
15tryptophan metabolic process (GO:0006568)5.56412666
16alpha-linolenic acid metabolic process (GO:0036109)5.43100114
17cysteine metabolic process (GO:0006534)5.39584578
18sulfur amino acid catabolic process (GO:0000098)5.34915986
19urea metabolic process (GO:0019627)5.31372201
20urea cycle (GO:0000050)5.31372201
21high-density lipoprotein particle remodeling (GO:0034375)5.31298865
22serine family amino acid catabolic process (GO:0009071)5.27705556
23negative regulation of fibrinolysis (GO:0051918)5.24484480
24ribosomal small subunit assembly (GO:0000028)5.22573549
25lysine catabolic process (GO:0006554)5.07860973
26lysine metabolic process (GO:0006553)5.07860973
27regulation of fibrinolysis (GO:0051917)5.00807146
28protein carboxylation (GO:0018214)4.98412631
29peptidyl-glutamic acid carboxylation (GO:0017187)4.98412631
30nitrogen cycle metabolic process (GO:0071941)4.90983576
31regulation of protein activation cascade (GO:2000257)4.90349385
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.89571974
33regulation of triglyceride catabolic process (GO:0010896)4.89347819
34regulation of cholesterol esterification (GO:0010872)4.88972424
35complement activation, alternative pathway (GO:0006957)4.86361311
36exogenous drug catabolic process (GO:0042738)4.83183022
37aromatic amino acid family metabolic process (GO:0009072)4.82007693
38viral transcription (GO:0019083)4.81497758
39amino-acid betaine metabolic process (GO:0006577)4.80608956
40bile acid metabolic process (GO:0008206)4.80178400
41homocysteine metabolic process (GO:0050667)4.79601500
42pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.79121473
43alpha-amino acid catabolic process (GO:1901606)4.71668669
44mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.68387127
45reverse cholesterol transport (GO:0043691)4.66200729
46plasma lipoprotein particle remodeling (GO:0034369)4.65124059
47protein-lipid complex remodeling (GO:0034368)4.65124059
48macromolecular complex remodeling (GO:0034367)4.65124059
49epoxygenase P450 pathway (GO:0019373)4.64193665
50cellular ketone body metabolic process (GO:0046950)4.62021166
51regulation of complement activation (GO:0030449)4.57864036
52glycine metabolic process (GO:0006544)4.56593641
53translational termination (GO:0006415)4.53901011
54tyrosine metabolic process (GO:0006570)4.52150685
55ATP synthesis coupled proton transport (GO:0015986)4.47756087
56energy coupled proton transport, down electrochemical gradient (GO:0015985)4.47756087
57negative regulation of cholesterol transport (GO:0032375)4.43827281
58negative regulation of sterol transport (GO:0032372)4.43827281
59triglyceride homeostasis (GO:0070328)4.43785577
60acylglycerol homeostasis (GO:0055090)4.43785577
61cellular amino acid catabolic process (GO:0009063)4.38385455
62phospholipid efflux (GO:0033700)4.36748173
63serine family amino acid metabolic process (GO:0009069)4.33887080
64coenzyme catabolic process (GO:0009109)4.30994651
65ethanol oxidation (GO:0006069)4.27593753
66plasma lipoprotein particle clearance (GO:0034381)4.27331267
67glutamate metabolic process (GO:0006536)4.19274528
68serine family amino acid biosynthetic process (GO:0009070)4.17310830
69pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.15513621
70indolalkylamine metabolic process (GO:0006586)4.15389131
71amine catabolic process (GO:0009310)4.12688777
72cellular biogenic amine catabolic process (GO:0042402)4.12688777
73cellular modified amino acid catabolic process (GO:0042219)4.11196558
74short-chain fatty acid metabolic process (GO:0046459)4.09958409
75omega-hydroxylase P450 pathway (GO:0097267)4.06780231
76imidazole-containing compound metabolic process (GO:0052803)4.06712445
77dicarboxylic acid biosynthetic process (GO:0043650)4.01598589
78acetyl-CoA metabolic process (GO:0006084)4.00744395
79aspartate family amino acid catabolic process (GO:0009068)4.00328442
80bile acid and bile salt transport (GO:0015721)4.00167923
81low-density lipoprotein particle remodeling (GO:0034374)3.99085447
82translational elongation (GO:0006414)3.98985153
83maturation of SSU-rRNA (GO:0030490)3.98957881
84ketone body metabolic process (GO:1902224)3.98839717
85benzene-containing compound metabolic process (GO:0042537)3.98051932
86pyrimidine nucleotide catabolic process (GO:0006244)3.97774195
87cellular glucuronidation (GO:0052695)3.97376426
882-oxoglutarate metabolic process (GO:0006103)3.94331880
89cholesterol efflux (GO:0033344)3.92464145
90organic acid catabolic process (GO:0016054)3.92281643
91carboxylic acid catabolic process (GO:0046395)3.92281643
92arginine metabolic process (GO:0006525)3.91521322
93SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.87633672
94plasma lipoprotein particle assembly (GO:0034377)3.85821986
95fatty acid beta-oxidation (GO:0006635)3.82752519
96aldehyde catabolic process (GO:0046185)3.81993956
97drug catabolic process (GO:0042737)3.79760190
98cotranslational protein targeting to membrane (GO:0006613)3.78589569
99protein targeting to ER (GO:0045047)3.77616551
100fatty acid oxidation (GO:0019395)3.75309115
101drug metabolic process (GO:0017144)3.75212892
102phospholipid homeostasis (GO:0055091)3.71669139
103monocarboxylic acid catabolic process (GO:0072329)3.71169762
104regulation of mitochondrial translation (GO:0070129)3.71131350
105lipid oxidation (GO:0034440)3.69954473
106carnitine metabolic process (GO:0009437)3.69708222
107positive regulation of triglyceride lipase activity (GO:0061365)3.69285621
108positive regulation of lipoprotein lipase activity (GO:0051006)3.69285621
109positive regulation of lipid catabolic process (GO:0050996)3.67849812
110cofactor catabolic process (GO:0051187)3.67241394
111L-serine metabolic process (GO:0006563)3.66688310
112DNA strand elongation involved in DNA replication (GO:0006271)3.66460879
113fibrinolysis (GO:0042730)3.66417281
114protein localization to endoplasmic reticulum (GO:0070972)3.65886242
115respiratory electron transport chain (GO:0022904)3.65104051
116fatty acid catabolic process (GO:0009062)3.64228601
117cholesterol homeostasis (GO:0042632)3.63673941
118very-low-density lipoprotein particle assembly (GO:0034379)3.63625361
119viral life cycle (GO:0019058)3.62933765
120negative regulation of lipase activity (GO:0060192)3.61229801
121cellular protein complex disassembly (GO:0043624)3.60391934
122blood coagulation, intrinsic pathway (GO:0007597)3.60078065
123establishment of protein localization to endoplasmic reticulum (GO:0072599)3.57740500
124sterol homeostasis (GO:0055092)3.57531343
125doxorubicin metabolic process (GO:0044598)3.56460980
126daunorubicin metabolic process (GO:0044597)3.56460980
127polyketide metabolic process (GO:0030638)3.56460980
128phenylpropanoid metabolic process (GO:0009698)3.56020328
129regulation of bile acid biosynthetic process (GO:0070857)3.55900835
130DNA strand elongation (GO:0022616)3.54964175
131electron transport chain (GO:0022900)3.54804245
132heme transport (GO:0015886)3.53840325
133positive regulation of fatty acid beta-oxidation (GO:0032000)3.53151841
134plasma lipoprotein particle organization (GO:0071827)3.51807480
135oxidative phosphorylation (GO:0006119)3.49465921
136chaperone-mediated protein transport (GO:0072321)3.44531070
137nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.43734078
138telomere maintenance via semi-conservative replication (GO:0032201)3.37760907
139oxidative demethylation (GO:0070989)3.34822512
140deoxyribose phosphate biosynthetic process (GO:0046385)3.34083116
1412-deoxyribonucleotide biosynthetic process (GO:0009265)3.34083116
142protein complex biogenesis (GO:0070271)3.33093337
143uronic acid metabolic process (GO:0006063)3.30263381
144glucuronate metabolic process (GO:0019585)3.30263381
145protein complex disassembly (GO:0043241)3.25130883
146response to misfolded protein (GO:0051788)3.24716957
147pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.23509740
148proline metabolic process (GO:0006560)3.23340278
149deoxyribonucleotide catabolic process (GO:0009264)3.22415903
150NADH metabolic process (GO:0006734)3.22294917
151ethanol metabolic process (GO:0006067)3.19662199
152aminoglycoside antibiotic metabolic process (GO:0030647)3.18991961
153mitochondrial respiratory chain complex I assembly (GO:0032981)3.15920002
154NADH dehydrogenase complex assembly (GO:0010257)3.15920002
155mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.15920002
156mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.15866994
157metallo-sulfur cluster assembly (GO:0031163)3.12689280
158iron-sulfur cluster assembly (GO:0016226)3.12689280
159ncRNA 3-end processing (GO:0043628)3.10915144
160mitochondrial respiratory chain complex assembly (GO:0033108)3.10649594
161macromolecular complex disassembly (GO:0032984)3.07220372
162deoxyribose phosphate catabolic process (GO:0046386)3.04532351
163DNA unwinding involved in DNA replication (GO:0006268)3.01195134
164translational initiation (GO:0006413)2.97368679
165oxaloacetate metabolic process (GO:0006107)2.95691569
166deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.92907078
167pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.85801950
168quinone metabolic process (GO:1901661)2.84921457
169quinone biosynthetic process (GO:1901663)2.81496961
170ribosomal large subunit biogenesis (GO:0042273)2.80940305

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.16577543
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.08230350
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.61744536
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.27294871
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.94735121
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.19440952
7E2F7_22180533_ChIP-Seq_HELA_Human5.11873335
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.05170316
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.16819554
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.95337804
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.85449475
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34239852
13MYC_18555785_ChIP-Seq_MESCs_Mouse3.27501076
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.18423570
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.84423210
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82982458
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.61236401
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.50608289
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.45063322
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28675468
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.27689536
22XRN2_22483619_ChIP-Seq_HELA_Human2.23757093
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.18778128
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.15978006
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.00974907
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7644535
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95487437
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91301587
29VDR_21846776_ChIP-Seq_THP-1_Human1.90459255
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.88021544
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.81468070
32CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.80892644
33SRY_22984422_ChIP-ChIP_TESTIS_Rat1.80598777
34GABP_19822575_ChIP-Seq_HepG2_Human1.80447351
35CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72396560
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68671770
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.64080054
38TTF2_22483619_ChIP-Seq_HELA_Human1.63849143
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.61193199
40* CLOCK_20551151_ChIP-Seq_293T_Human1.59315876
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57236778
42P68_20966046_ChIP-Seq_HELA_Human1.57148573
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52459778
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.51346900
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.51182826
46GATA1_22025678_ChIP-Seq_K562_Human1.51133083
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.49375313
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47905064
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47432517
50BCL6_27268052_Chip-Seq_Bcells_Human1.45138776
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.43424981
52HTT_18923047_ChIP-ChIP_STHdh_Human1.40589278
53DCP1A_22483619_ChIP-Seq_HELA_Human1.39550146
54CTCF_18555785_ChIP-Seq_MESCs_Mouse1.39292147
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36599038
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.36270942
57HNF4A_19822575_ChIP-Seq_HepG2_Human1.35448194
58* FOXP1_21924763_ChIP-Seq_HESCs_Human1.34618949
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34398468
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34005301
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31782159
62E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30281720
63SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.30039282
64* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28275669
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25815685
66RXRA_24833708_ChIP-Seq_LIVER_Mouse1.23496138
67KDM5A_27292631_Chip-Seq_BREAST_Human1.22254655
68YY1_22570637_ChIP-Seq_MALME-3M_Human1.21350118
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20520248
70FOXP3_21729870_ChIP-Seq_TREG_Human1.20125644
71PHF8_20622854_ChIP-Seq_HELA_Human1.19348238
72* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.18541656
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17068262
74SA1_27219007_Chip-Seq_ERYTHROID_Human1.15345969
75ZNF263_19887448_ChIP-Seq_K562_Human1.15282669
76CTCF_26484167_Chip-Seq_Bcells_Mouse1.15040181
77E2F1_21310950_ChIP-Seq_MCF-7_Human1.14095192
78* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14072675
79E2F1_20622854_ChIP-Seq_HELA_Human1.13355961
80IRF1_19129219_ChIP-ChIP_H3396_Human1.11317303
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08036142
82TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07544845
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06937150
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06567637
85CTCF_20526341_ChIP-Seq_ESCs_Human1.06456069
86SMC4_20622854_ChIP-Seq_HELA_Human1.05181132
87MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04614180
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04550497
89NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04215462
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04113297
91ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03018854
92SA1_27219007_Chip-Seq_Bcells_Human1.03016798
93CIITA_25753668_ChIP-Seq_RAJI_Human1.02682057
94MYC_22102868_ChIP-Seq_BL_Human1.01132766
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00727680
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00451438
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98703799
98* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98382734
99BP1_19119308_ChIP-ChIP_Hs578T_Human0.98373920
100NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97047023
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96547843
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95561690
103* ERG_21242973_ChIP-ChIP_JURKAT_Human0.95351345
104CTCF_21964334_Chip-Seq_Bcells_Human0.94966967
105ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94575552
106PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93822133
107AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93471187
108SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89638616
109SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.84802066
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83711816
111KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81177342
112NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79809597
113RARA_24833708_ChIP-Seq_LIVER_Mouse0.79418706
114GATA4_25053715_ChIP-Seq_YYC3_Human0.79313779
115STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.78494637
116IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.77139109
117RARB_24833708_ChIP-Seq_LIVER_Mouse0.69275479
118SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69021194
119PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.68810933
120BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.68565423
121ESR2_21235772_ChIP-Seq_MCF-7_Human0.67797723
122RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67608513
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.66708712
124AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.62015367
125PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.61947002
126CEBPB_22108803_ChIP-Seq_LS180_Human0.61478145
127POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.58114145
128LXR_22292898_ChIP-Seq_THP-1_Human0.57451055
129CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.55560905
130* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.54320434
131AR_20517297_ChIP-Seq_VCAP_Human0.53174079
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52128019
133TAF2_19829295_ChIP-Seq_ESCs_Human0.50296820
134ESET_19884257_ChIP-Seq_ESCs_Mouse0.49988336
135PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.49668639
136P53_21459846_ChIP-Seq_SAOS-2_Human0.49647035
137TBX20_22080862_ChIP-Seq_HEART_Mouse0.48531125
138TBX20_22328084_ChIP-Seq_HEART_Mouse0.48531125
139RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.48013863
140BCOR_27268052_Chip-Seq_Bcells_Human0.47769593
141SOX2_18692474_ChIP-Seq_MEFs_Mouse0.47500320
142SRF_21415370_ChIP-Seq_HL-1_Mouse0.47191270
143* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.46357355
144FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.46236411
145PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45037959
146SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.44925827
147SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.44725897
148GATA1_19941827_ChIP-Seq_MEL_Mouse0.44286482
149CBP_21632823_ChIP-Seq_H3396_Human0.44239936
150EGR1_19032775_ChIP-ChIP_M12_Human0.44086802
151CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.43440154
152GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.42352483
153MYC_19915707_ChIP-ChIP_AK7_Human0.42257917
154TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.42142695
155* FOXA1_25552417_ChIP-Seq_VCAP_Human0.42121321
156TET1_21451524_ChIP-Seq_MESCs_Mouse0.42113911
157STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.41714182
158CSB_26484114_Chip-Seq_FIBROBLAST_Human0.40867343
159NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.40775248
160NRF2_20460467_ChIP-Seq_MEFs_Mouse0.40775248
161PPAR_26484153_Chip-Seq_NCI-H1993_Human0.40421734
162ERG_20517297_ChIP-Seq_VCAP_Human0.40170035
163* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.40003412
164GATA6_25053715_ChIP-Seq_YYC3_Human0.39972142
165AR_21909140_ChIP-Seq_LNCAP_Human0.39965841
166SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39278833
167Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.39170278
168GATA1_19941826_ChIP-Seq_K562_Human0.38972808
169IRF8_22096565_ChIP-ChIP_GC-B_Human0.38873661
170STAT1_17558387_ChIP-Seq_HELA_Human0.38535395
171MYC_27129775_Chip-Seq_CORNEA_Mouse0.38474897
172RACK7_27058665_Chip-Seq_MCF-7_Human0.38112245
173BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.37583170

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.92911466
2MP0005360_urolithiasis7.34918259
3MP0005085_abnormal_gallbladder_physiolo6.18200502
4MP0005365_abnormal_bile_salt5.93029892
5MP0008875_abnormal_xenobiotic_pharmacok4.93323576
6MP0003806_abnormal_nucleotide_metabolis4.47788905
7MP0009840_abnormal_foam_cell3.62844441
8MP0003252_abnormal_bile_duct3.62139059
9MP0009379_abnormal_foot_pigmentation3.49575522
10MP0010329_abnormal_lipoprotein_level3.47675954
11MP0005332_abnormal_amino_acid3.00644357
12MP0005083_abnormal_biliary_tract2.91431777
13MP0003195_calcinosis2.83057754
14MP0001666_abnormal_nutrient_absorption2.40274231
15MP0003191_abnormal_cellular_cholesterol2.32677867
16MP0004019_abnormal_vitamin_homeostasis2.13914626
17MP0002118_abnormal_lipid_homeostasis2.11538053
18* MP0000609_abnormal_liver_physiology2.10691515
19MP0006292_abnormal_olfactory_placode1.98231334
20MP0005319_abnormal_enzyme/_coenzyme1.93902416
21MP0003693_abnormal_embryo_hatching1.93552461
22MP0010094_abnormal_chromosome_stability1.93361927
23MP0008932_abnormal_embryonic_tissue1.80238425
24MP0002138_abnormal_hepatobiliary_system1.79010935
25MP0008058_abnormal_DNA_repair1.75771834
26MP0001764_abnormal_homeostasis1.74496919
27MP0008789_abnormal_olfactory_epithelium1.69502297
28MP0004147_increased_porphyrin_level1.69016511
29MP0005584_abnormal_enzyme/coenzyme_acti1.61797972
30MP0002234_abnormal_pharynx_morphology1.61519854
31MP0003868_abnormal_feces_composition1.60669318
32MP0005451_abnormal_body_composition1.59312836
33MP0003186_abnormal_redox_activity1.57712311
34MP0000678_abnormal_parathyroid_gland1.57441587
35MP0009697_abnormal_copulation1.52365144
36MP0003111_abnormal_nucleus_morphology1.48323105
37MP0002653_abnormal_ependyma_morphology1.43968001
38MP0002249_abnormal_larynx_morphology1.42204879
39MP0003011_delayed_dark_adaptation1.37803184
40MP0003656_abnormal_erythrocyte_physiolo1.37779238
41MP0005645_abnormal_hypothalamus_physiol1.36461755
42MP0002160_abnormal_reproductive_system1.35922558
43MP0004145_abnormal_muscle_electrophysio1.34896696
44MP0006036_abnormal_mitochondrial_physio1.33882856
45* MP0009643_abnormal_urine_homeostasis1.32631942
46MP0002837_dystrophic_cardiac_calcinosis1.31927856
47MP0005397_hematopoietic_system_phenotyp1.31651186
48MP0001545_abnormal_hematopoietic_system1.31651186
49MP0002132_abnormal_respiratory_system1.29963083
50MP0005499_abnormal_olfactory_system1.25245893
51MP0005394_taste/olfaction_phenotype1.25245893
52MP0005670_abnormal_white_adipose1.25120104
53MP0004957_abnormal_blastocyst_morpholog1.20756247
54MP0003705_abnormal_hypodermis_morpholog1.17993083
55MP0000598_abnormal_liver_morphology1.15679382
56MP0003315_abnormal_perineum_morphology1.13657967
57MP0001727_abnormal_embryo_implantation1.13241592
58MP0004130_abnormal_muscle_cell1.13184013
59MP0005647_abnormal_sex_gland1.13081330
60MP0003786_premature_aging1.08453494
61MP0008007_abnormal_cellular_replicative1.06617059
62MP0003077_abnormal_cell_cycle1.06264084
63MP0003123_paternal_imprinting1.06207355
64MP0001905_abnormal_dopamine_level1.05712667
65MP0009278_abnormal_bone_marrow1.05585905
66MP0000604_amyloidosis1.00610939
67MP0005636_abnormal_mineral_homeostasis0.98881964
68MP0009763_increased_sensitivity_to0.97834946
69MP0009764_decreased_sensitivity_to0.94563712
70MP0002254_reproductive_system_inflammat0.92564948
71MP0010368_abnormal_lymphatic_system0.89861183
72MP0001529_abnormal_vocalization0.89665862
73MP0005410_abnormal_fertilization0.89304774
74MP0006035_abnormal_mitochondrial_morpho0.86616985
75MP0002971_abnormal_brown_adipose0.85604286
76* MP0009642_abnormal_blood_homeostasis0.84729286
77MP0008469_abnormal_protein_level0.83150195
78* MP0005376_homeostasis/metabolism_phenot0.82536553
79MP0002163_abnormal_gland_morphology0.82388561
80MP0000049_abnormal_middle_ear0.82058386
81MP0003646_muscle_fatigue0.81835390
82MP0001661_extended_life_span0.81159447
83MP0002078_abnormal_glucose_homeostasis0.80682161
84* MP0005266_abnormal_metabolism0.75662054
85MP0004142_abnormal_muscle_tone0.75640640
86MP0005666_abnormal_adipose_tissue0.75284872
87MP0005330_cardiomyopathy0.74147137
88MP0005389_reproductive_system_phenotype0.73602727
89MP0001756_abnormal_urination0.72723479
90MP0000681_abnormal_thyroid_gland0.70742839
91MP0005535_abnormal_body_temperature0.70302776
92MP0005334_abnormal_fat_pad0.70216076
93MP0002638_abnormal_pupillary_reflex0.70162986
94MP0005408_hypopigmentation0.70021171
95MP0005501_abnormal_skin_physiology0.69525869
96MP0003690_abnormal_glial_cell0.69426075
97MP0003329_amyloid_beta_deposits0.68815644
98MP0000490_abnormal_crypts_of0.67464832
99MP0009765_abnormal_xenobiotic_induced0.64467673
100MP0001929_abnormal_gametogenesis0.64391352
101MP0004858_abnormal_nervous_system0.64384789
102MP0005084_abnormal_gallbladder_morpholo0.64074485
103MP0002092_abnormal_eye_morphology0.63932843
104MP0003698_abnormal_male_reproductive0.63382622
105MP0003718_maternal_effect0.62378951
106MP0008995_early_reproductive_senescence0.62061743
107MP0000003_abnormal_adipose_tissue0.61706030
108MP0002269_muscular_atrophy0.61673120
109MP0002019_abnormal_tumor_incidence0.61663042
110MP0002876_abnormal_thyroid_physiology0.61520609
111MP0003879_abnormal_hair_cell0.58402109
112MP0000313_abnormal_cell_death0.56488799
113MP0001919_abnormal_reproductive_system0.56371537
114MP0000653_abnormal_sex_gland0.55081227
115MP0005220_abnormal_exocrine_pancreas0.54944030
116MP0005395_other_phenotype0.52339240
117MP0002136_abnormal_kidney_physiology0.50762875
118MP0004043_abnormal_pH_regulation0.50247357
119MP0009053_abnormal_anal_canal0.48606143
120MP0001853_heart_inflammation0.47961928
121MP0005448_abnormal_energy_balance0.47606895
122MP0000639_abnormal_adrenal_gland0.47468008
123MP0009115_abnormal_fat_cell0.44757313
124MP0003638_abnormal_response/metabolism_0.44278863
125MP0002332_abnormal_exercise_endurance0.44097903
126MP0000230_abnormal_systemic_arterial0.43540134
127MP0004036_abnormal_muscle_relaxation0.41050020
128MP0008873_increased_physiological_sensi0.40858790
129MP0003075_altered_response_to0.39077575
130MP0008874_decreased_physiological_sensi0.38815716
131MP0003953_abnormal_hormone_level0.38618422
132MP0003221_abnormal_cardiomyocyte_apopto0.38106546
133MP0001544_abnormal_cardiovascular_syste0.37343542
134MP0005385_cardiovascular_system_phenoty0.37343542
135MP0002970_abnormal_white_adipose0.37031294
136MP0009672_abnormal_birth_weight0.36357100
137MP0008872_abnormal_physiological_respon0.35694829
138MP0000579_abnormal_nail_morphology0.34998915
139MP0006138_congestive_heart_failure0.34832746
140MP0005165_increased_susceptibility_to0.33563875
141MP0004782_abnormal_surfactant_physiolog0.32872761
142MP0002822_catalepsy0.32544257
143MP0000249_abnormal_blood_vessel0.32397516
144MP0002796_impaired_skin_barrier0.31318284
145MP0004215_abnormal_myocardial_fiber0.31273802
146MP0004087_abnormal_muscle_fiber0.30791283
147MP0005464_abnormal_platelet_physiology0.30525093
148MP0005166_decreased_susceptibility_to0.30286469
149MP0004185_abnormal_adipocyte_glucose0.29865705
150MP0000749_muscle_degeneration0.29847489
151MP0000747_muscle_weakness0.29692281

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.96003056
2Intrahepatic cholestasis (HP:0001406)6.69601345
3Deep venous thrombosis (HP:0002625)6.67517056
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.16390767
5Xanthomatosis (HP:0000991)6.07719881
6Hypobetalipoproteinemia (HP:0003563)5.86222083
7Prolonged partial thromboplastin time (HP:0003645)5.84594476
8Hyperlipoproteinemia (HP:0010980)5.49851831
9Abnormal mitochondria in muscle tissue (HP:0008316)5.02016180
10Hyperammonemia (HP:0001987)4.94242974
11Hyperglycinemia (HP:0002154)4.87278602
12Hyperglycinuria (HP:0003108)4.73178043
13Complement deficiency (HP:0004431)4.66995555
14Hypolipoproteinemia (HP:0010981)4.64642681
15Ketosis (HP:0001946)4.62128569
16Abnormality of serine family amino acid metabolism (HP:0010894)4.55275367
17Abnormality of glycine metabolism (HP:0010895)4.55275367
18Acute necrotizing encephalopathy (HP:0006965)4.48354792
19Reticulocytopenia (HP:0001896)4.37058251
20Hypoalphalipoproteinemia (HP:0003233)4.26954441
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.25865940
22Joint hemorrhage (HP:0005261)4.21421726
23Hypoglycemic coma (HP:0001325)4.21186569
24Abnormality of methionine metabolism (HP:0010901)4.20444232
25Abnormality of aspartate family amino acid metabolism (HP:0010899)4.14434839
26Abnormality of sulfur amino acid metabolism (HP:0004339)4.13825045
27Abnormality of cells of the erythroid lineage (HP:0012130)4.13786146
28Epidermoid cyst (HP:0200040)4.09778917
29Abnormality of glutamine family amino acid metabolism (HP:0010902)4.02427809
30Mitochondrial inheritance (HP:0001427)3.94199344
31Hepatocellular necrosis (HP:0001404)3.91027022
32Abnormality of fatty-acid metabolism (HP:0004359)3.90113341
33Increased muscle lipid content (HP:0009058)3.87877927
34Increased intramyocellular lipid droplets (HP:0012240)3.87869773
35Abnormality of the common coagulation pathway (HP:0010990)3.85494707
36Abnormal number of erythroid precursors (HP:0012131)3.73202772
37Abnormality of pyrimidine metabolism (HP:0004353)3.67780601
38Fat malabsorption (HP:0002630)3.67547496
39Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.57824786
40Ketoacidosis (HP:0001993)3.55478161
41Decreased activity of mitochondrial respiratory chain (HP:0008972)3.47183550
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.47183550
43Abnormality of serum amino acid levels (HP:0003112)3.42366354
44Increased CSF lactate (HP:0002490)3.40932179
45Hypercholesterolemia (HP:0003124)3.39370920
46Abnormality of the intrinsic pathway (HP:0010989)3.37526665
47Abnormality of complement system (HP:0005339)3.33789062
48Increased serum pyruvate (HP:0003542)3.33120740
49Progressive macrocephaly (HP:0004481)3.32462954
50Delayed CNS myelination (HP:0002188)3.27328865
51Abnormality of dicarboxylic acid metabolism (HP:0010995)3.26574658
52Dicarboxylic aciduria (HP:0003215)3.26574658
53Macrocytic anemia (HP:0001972)3.25750043
54Ragged-red muscle fibers (HP:0003200)3.22911091
55Hyperbilirubinemia (HP:0002904)3.18897717
56Cerebral edema (HP:0002181)3.16050342
57Lethargy (HP:0001254)3.11569715
58Abnormality of nucleobase metabolism (HP:0010932)3.06392077
59Metabolic acidosis (HP:0001942)3.05247032
60Aplasia/Hypoplasia of the sacrum (HP:0008517)3.04658741
61Cerebral palsy (HP:0100021)3.00530920
62Conjugated hyperbilirubinemia (HP:0002908)2.99516002
63Abnormality of glycolysis (HP:0004366)2.94960535
64Hyperthyroidism (HP:0000836)2.90299475
65Lactic acidosis (HP:0003128)2.88653499
66Renal Fanconi syndrome (HP:0001994)2.85845424
67Gout (HP:0001997)2.82450395
68Steatorrhea (HP:0002570)2.79590056
69Pallor (HP:0000980)2.76972888
70Microvesicular hepatic steatosis (HP:0001414)2.76470780
71Exercise intolerance (HP:0003546)2.76237650
72Abnormality of purine metabolism (HP:0004352)2.75697815
73Impulsivity (HP:0100710)2.75012805
74Hepatocellular carcinoma (HP:0001402)2.72078572
75Skin nodule (HP:0200036)2.67135085
76Abnormality of reticulocytes (HP:0004312)2.63707427
77Myocardial infarction (HP:0001658)2.63475004
78Increased serum lactate (HP:0002151)2.62179184
79Lipid accumulation in hepatocytes (HP:0006561)2.61883420
80Spontaneous abortion (HP:0005268)2.61556794
81Hypochromic microcytic anemia (HP:0004840)2.52419393
82Generalized aminoaciduria (HP:0002909)2.51387848
83Vascular calcification (HP:0004934)2.45385379
84Vomiting (HP:0002013)2.45051337
85Abnormal gallbladder morphology (HP:0012437)2.41840253
86Cholelithiasis (HP:0001081)2.41293236
87Reduced antithrombin III activity (HP:0001976)2.39950790
88Irritability (HP:0000737)2.36065858
89Increased hepatocellular lipid droplets (HP:0006565)2.35106038
90Microretrognathia (HP:0000308)2.35008259
91Spastic diplegia (HP:0001264)2.34019480
92Hyperphosphaturia (HP:0003109)2.33910605
93Systemic lupus erythematosus (HP:0002725)2.32700684
94Hypoglycemic seizures (HP:0002173)2.30878896
953-Methylglutaconic aciduria (HP:0003535)2.28865692
96Neonatal onset (HP:0003623)2.25513545
97Late onset (HP:0003584)2.25342529
98Respiratory failure (HP:0002878)2.24940174
99Malnutrition (HP:0004395)2.19835943
100Rhabdomyolysis (HP:0003201)2.18440137
101Acanthocytosis (HP:0001927)2.17892284
102Cardiovascular calcification (HP:0011915)2.15282346
103Brushfield spots (HP:0001088)2.14893997
104Hyperinsulinemic hypoglycemia (HP:0000825)2.14370666
105Pancreatitis (HP:0001733)2.13264406
106Proximal tubulopathy (HP:0000114)2.12237676
107Myokymia (HP:0002411)2.11249200
108Chromsome breakage (HP:0040012)2.10694559
109Cholecystitis (HP:0001082)2.07315628
110Abnormal gallbladder physiology (HP:0012438)2.07315628
111Amyloidosis (HP:0011034)2.06904551
112Myoglobinuria (HP:0002913)2.06099823
113Renal cortical cysts (HP:0000803)2.05046406
114Abnormality of the Achilles tendon (HP:0005109)2.04846641
115Nausea (HP:0002018)2.04665621
116Abnormal protein glycosylation (HP:0012346)2.03238641
117Abnormal glycosylation (HP:0012345)2.03238641
118Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03238641
119Abnormal protein N-linked glycosylation (HP:0012347)2.03238641
120Esophageal varix (HP:0002040)2.02353484
121Acute encephalopathy (HP:0006846)2.02312324
122Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01646476
123Sensorimotor neuropathy (HP:0007141)2.01606252
124Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01562250
125Glomerulonephritis (HP:0000099)2.00387085
126Mitral stenosis (HP:0001718)1.99767669
127Opisthotonus (HP:0002179)1.99481069
128Increased purine levels (HP:0004368)1.99434116
129Hyperuricemia (HP:0002149)1.99434116
130Enlarged kidneys (HP:0000105)1.98707466
131Abnormal cartilage morphology (HP:0002763)1.98294748
132Progressive muscle weakness (HP:0003323)1.98287864
133Hepatic necrosis (HP:0002605)1.96388315
134Abnormal urine phosphate concentration (HP:0012599)1.96344450
135Abnormality of iron homeostasis (HP:0011031)1.95386708
136Seborrheic dermatitis (HP:0001051)1.94976009
137Abnormality of transition element cation homeostasis (HP:0011030)1.93511177
138Abnormality of urine glucose concentration (HP:0011016)1.93099737
139Glycosuria (HP:0003076)1.93099737
140Abnormality of proline metabolism (HP:0010907)1.90250169
141Hydroxyprolinuria (HP:0003080)1.90250169
142Abnormality of the gallbladder (HP:0005264)1.90231573
143CNS demyelination (HP:0007305)1.89332292
144Abnormality of the heme biosynthetic pathway (HP:0010472)1.87920529
145Poikilocytosis (HP:0004447)1.86702943
146Type I transferrin isoform profile (HP:0003642)1.86297919
147Thrombophlebitis (HP:0004418)1.84575227
148Alkalosis (HP:0001948)1.84167241
149Hyperglycemia (HP:0003074)1.83610695
150Abnormality of vitamin metabolism (HP:0100508)1.83472999
151Tubulointerstitial nephritis (HP:0001970)1.82094774
152Reticulocytosis (HP:0001923)1.81593879
153Truncus arteriosus (HP:0001660)1.81049604
154Broad distal phalanx of finger (HP:0009836)1.80730462
155Elevated hepatic transaminases (HP:0002910)1.79478938
156Leukodystrophy (HP:0002415)1.78582548
157Emotional lability (HP:0000712)1.78185188
158Hypertensive crisis (HP:0100735)1.77389342
159Pancytopenia (HP:0001876)1.75919514
160Achilles tendon contracture (HP:0001771)1.74164396

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK8.35850405
2SIK14.14908374
3FGFR43.82681273
4ERN13.64968655
5VRK23.61337794
6CDC73.20610086
7STK163.01671486
8SCYL22.84144808
9TESK22.68273195
10PIM22.60736626
11ARAF2.56276231
12PKN22.38000477
13TRIB32.37333882
14LIMK12.29275662
15INSRR2.28356071
16TESK12.25098074
17ERBB42.25082043
18PINK12.16037119
19CDK82.13498561
20TAOK32.03583922
21MAPK111.91776818
22FLT31.89568732
23PDK41.79018905
24PDK31.79018905
25MAP2K41.75564548
26TLK11.68815255
27SRPK11.68346044
28AURKA1.60411187
29PIK3CG1.60015834
30MST1R1.55981206
31VRK11.52700521
32LRRK21.49147694
33STK38L1.46530702
34LATS11.46499277
35ABL21.45229546
36KDR1.42695930
37NEK91.36210478
38TYK21.35861948
39DYRK21.35685055
40CCNB11.33508967
41BUB11.33062209
42SMG11.32787879
43MAP2K31.27978670
44TTN1.27115844
45PRKAA21.26386431
46DYRK31.24845437
47ZAK1.24136262
48NEK11.20992485
49NME21.18881616
50PLK41.18770825
51MAPK121.18770158
52OBSCN1.16862916
53EPHB21.15516497
54ATR1.14465328
55MAP3K71.14309746
56BRAF1.13772337
57TIE11.13764525
58PHKG21.12638788
59PHKG11.12638788
60DAPK11.12240236
61EIF2AK11.11684613
62NME11.08091994
63CDK71.06069018
64DAPK21.05578273
65CHEK21.04268520
66PTK61.03284678
67JAK21.03201887
68GRK61.02464092
69AURKB1.02410345
70PDK21.00072587
71MYLK0.99261701
72MAP3K30.95897037
73ILK0.94856091
74PLK10.92946440
75PRKAA10.92872004
76RPS6KA50.91306712
77MAPK40.90655854
78LMTK20.90565093
79MAP3K110.88227934
80CSNK1G30.86552468
81CSNK2A20.81871689
82CAMK2G0.80210371
83FGFR20.78768631
84NUAK10.78330595
85PRKACG0.77542803
86MINK10.74209387
87RPS6KB20.73776624
88MAP2K60.72376069
89BRSK10.71182615
90CSNK2A10.70126086
91TAOK20.69394143
92MET0.68979743
93DAPK30.68451174
94PRKCZ0.68374635
95PIK3CA0.67934076
96MAPK150.66948880
97TBK10.66568436
98EPHB10.66411700
99MAP2K70.66408900
100MAP3K100.65621245
101ERBB20.64621425
102CDK60.63761953
103GSK3A0.62884159
104CSNK1G20.61251823
105CDK40.60721475
106MAP3K80.60406697
107JAK10.60299512
108IRAK30.60083643
109RPS6KA40.58082149
110FRK0.57480746
111MAP3K50.55587071
112WEE10.55364151
113CHEK10.55312412
114RPS6KC10.54631173
115RPS6KL10.54631173
116PRKCI0.53048746
117CDK140.52726934
118MAPK70.52137114
119SGK30.51483869
120PDPK10.50770808
121CSNK1A1L0.50699853
122CDK20.50116629
123PBK0.50033850
124DYRK1B0.49828230
125CDK11A0.49693816
126CAMK2D0.48828448
127CDK150.47619260
128RPS6KA60.46955232
129PAK10.46533953
130RAF10.46389937
131PAK30.45734601
132TGFBR20.45435011
133MAP3K60.43628063
134CSK0.42708872
135TAF10.40649323
136LATS20.40528193
137PKN10.40077859
138MTOR0.38591786
139DMPK0.38584845
140SGK20.38145741
141CDK180.37001682
142CAMK1D0.37000266
143CDK90.36614222
144PIM10.36005473
145CAMK40.35457777
146WNK40.35423739
147CSF1R0.34988940
148PRKD10.33783075
149PRKCQ0.33649479
150SGK2230.33535159
151SGK4940.33535159
152PRKCD0.33505802
153ICK0.33428094
154GRK10.32703283
155CSNK1A10.32441816
156PRKACB0.32169225
157RPS6KA20.32083052
158ATM0.31573565
159MAPKAPK30.31190105
160IGF1R0.28410158
161MAP2K10.28163677
162AKT20.27721655
163STK40.27259363
164PTK20.26601116
165PDK10.26508174
166EPHA20.26178780
167PRKACA0.26101648
168CSNK1G10.24572485
169MAP2K20.23341761
170MAP3K140.23279447
171EPHA30.22873911

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.14448747
2Nitrogen metabolism_Homo sapiens_hsa009103.39104175
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.36733210
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.09937120
5Ribosome_Homo sapiens_hsa030102.98716174
6Arginine biosynthesis_Homo sapiens_hsa002202.96456040
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.82417462
8Fatty acid degradation_Homo sapiens_hsa000712.71907585
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.65111410
10DNA replication_Homo sapiens_hsa030302.63932891
11Tryptophan metabolism_Homo sapiens_hsa003802.61283403
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.58259617
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.57688008
14Complement and coagulation cascades_Homo sapiens_hsa046102.43744335
15Propanoate metabolism_Homo sapiens_hsa006402.34120418
16Butanoate metabolism_Homo sapiens_hsa006502.22183288
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.16092568
18* Peroxisome_Homo sapiens_hsa041462.09597651
19Base excision repair_Homo sapiens_hsa034102.05443744
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.03305691
21Fatty acid metabolism_Homo sapiens_hsa012122.00266660
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.99567654
23PPAR signaling pathway_Homo sapiens_hsa033201.94376439
24Chemical carcinogenesis_Homo sapiens_hsa052041.84639219
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.84604207
26beta-Alanine metabolism_Homo sapiens_hsa004101.75858264
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73991277
28Histidine metabolism_Homo sapiens_hsa003401.73656973
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72385037
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.69522684
31Mismatch repair_Homo sapiens_hsa034301.66402301
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.64030856
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61657192
34Caffeine metabolism_Homo sapiens_hsa002321.60718830
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58200787
36Retinol metabolism_Homo sapiens_hsa008301.57382917
37Pyruvate metabolism_Homo sapiens_hsa006201.56618662
38Selenocompound metabolism_Homo sapiens_hsa004501.54148407
39Phenylalanine metabolism_Homo sapiens_hsa003601.49690868
40Staphylococcus aureus infection_Homo sapiens_hsa051501.47070630
41Carbon metabolism_Homo sapiens_hsa012001.43464559
42Fatty acid elongation_Homo sapiens_hsa000621.41825060
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.41312569
44Biosynthesis of amino acids_Homo sapiens_hsa012301.38258832
45Tyrosine metabolism_Homo sapiens_hsa003501.36637591
46Bile secretion_Homo sapiens_hsa049761.35873106
47Sulfur metabolism_Homo sapiens_hsa009201.31808735
48Folate biosynthesis_Homo sapiens_hsa007901.30072908
49Starch and sucrose metabolism_Homo sapiens_hsa005001.26995358
50Homologous recombination_Homo sapiens_hsa034401.23742454
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14220506
52Vitamin B6 metabolism_Homo sapiens_hsa007501.12703653
53Fat digestion and absorption_Homo sapiens_hsa049751.12149510
54Arginine and proline metabolism_Homo sapiens_hsa003301.12007338
55Sulfur relay system_Homo sapiens_hsa041221.07008791
56Steroid biosynthesis_Homo sapiens_hsa001001.06456676
57ABC transporters_Homo sapiens_hsa020101.04649924
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.99643399
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99536168
60Nucleotide excision repair_Homo sapiens_hsa034200.99408551
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97562832
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90035360
63Proteasome_Homo sapiens_hsa030500.89810238
64Fanconi anemia pathway_Homo sapiens_hsa034600.89230059
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88368226
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88345025
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85643761
68Vitamin digestion and absorption_Homo sapiens_hsa049770.85531025
69RNA polymerase_Homo sapiens_hsa030200.84874270
70One carbon pool by folate_Homo sapiens_hsa006700.80176849
71Lysine degradation_Homo sapiens_hsa003100.78972032
72Glutathione metabolism_Homo sapiens_hsa004800.77029046
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.76766450
74Glycerolipid metabolism_Homo sapiens_hsa005610.71461352
75Pentose phosphate pathway_Homo sapiens_hsa000300.70418730
76Fatty acid biosynthesis_Homo sapiens_hsa000610.69393074
77Metabolic pathways_Homo sapiens_hsa011000.56362573
78Spliceosome_Homo sapiens_hsa030400.56106262
79Purine metabolism_Homo sapiens_hsa002300.53540160
80Fructose and mannose metabolism_Homo sapiens_hsa000510.40205286
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39791329
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.39625068
83Cell cycle_Homo sapiens_hsa041100.38807499
84Galactose metabolism_Homo sapiens_hsa000520.35797553
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33362241
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31553523
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31032320
88Linoleic acid metabolism_Homo sapiens_hsa005910.29135220
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.26763760
90Insulin resistance_Homo sapiens_hsa049310.24639201
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24006576
92Prion diseases_Homo sapiens_hsa050200.22619881
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21867048
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.20213267
95N-Glycan biosynthesis_Homo sapiens_hsa005100.17389764
96RNA transport_Homo sapiens_hsa030130.16817499
97Oxidative phosphorylation_Homo sapiens_hsa001900.13837432
98Alcoholism_Homo sapiens_hsa050340.12402653
99Glucagon signaling pathway_Homo sapiens_hsa049220.11238457
100Parkinsons disease_Homo sapiens_hsa050120.10920922
101Protein export_Homo sapiens_hsa030600.09231548
102Non-homologous end-joining_Homo sapiens_hsa034500.07098821
103AMPK signaling pathway_Homo sapiens_hsa041520.07030023
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.01784168
105Circadian rhythm_Homo sapiens_hsa04710-0.2483152
106Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.2395401
107Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2271989
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.2160100
109Ether lipid metabolism_Homo sapiens_hsa00565-0.2089728
110Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2059029
111Renin-angiotensin system_Homo sapiens_hsa04614-0.1803612
112Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1772460
113Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1494183
114Pyrimidine metabolism_Homo sapiens_hsa00240-0.1492009
115Cardiac muscle contraction_Homo sapiens_hsa04260-0.1416646
116Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1292472
117Huntingtons disease_Homo sapiens_hsa05016-0.1033097
118Regulation of autophagy_Homo sapiens_hsa04140-0.0595235
119Insulin signaling pathway_Homo sapiens_hsa04910-0.0571787
120Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0371794
121Alzheimers disease_Homo sapiens_hsa05010-0.0271183

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