PXK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)6.71973332
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.92094454
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.92094454
4cellular response to zinc ion (GO:0071294)4.94734923
5Golgi transport vesicle coating (GO:0048200)4.92503120
6COPI coating of Golgi vesicle (GO:0048205)4.92503120
7B cell receptor signaling pathway (GO:0050853)4.82613801
8positive regulation of gamma-delta T cell activation (GO:0046645)4.76074768
9neutrophil mediated immunity (GO:0002446)4.16884166
10regulation of B cell receptor signaling pathway (GO:0050855)4.14622764
11synaptic vesicle exocytosis (GO:0016079)4.07538527
12cellular extravasation (GO:0045123)4.04758317
13synaptic vesicle maturation (GO:0016188)4.00792696
14regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.82619038
15regulation of gamma-delta T cell differentiation (GO:0045586)3.81932898
16neutrophil activation involved in immune response (GO:0002283)3.79344247
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.74240876
18positive regulation of B cell differentiation (GO:0045579)3.67668649
19axon ensheathment in central nervous system (GO:0032291)3.66325100
20central nervous system myelination (GO:0022010)3.66325100
21maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.60641907
22regulation of gamma-delta T cell activation (GO:0046643)3.59757001
23mature B cell differentiation (GO:0002335)3.57580782
24regulation of B cell differentiation (GO:0045577)3.57415505
25myeloid leukocyte mediated immunity (GO:0002444)3.50380645
26cytidine catabolic process (GO:0006216)3.49786486
27cytidine deamination (GO:0009972)3.49786486
28cytidine metabolic process (GO:0046087)3.49786486
29L-amino acid import (GO:0043092)3.47220700
30protein retention in ER lumen (GO:0006621)3.45133647
31regulation of interferon-beta biosynthetic process (GO:0045357)3.43461029
32positive regulation of macrophage cytokine production (GO:0060907)3.39022291
33positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.29077724
34antigen processing and presentation via MHC class Ib (GO:0002475)3.27509786
35response to peptidoglycan (GO:0032494)3.27424255
36regulation of macrophage cytokine production (GO:0010935)3.26828677
37pyrimidine ribonucleoside catabolic process (GO:0046133)3.24744104
38positive regulation of granulocyte differentiation (GO:0030854)3.22469713
39Arp2/3 complex-mediated actin nucleation (GO:0034314)3.22271111
40valine metabolic process (GO:0006573)3.20633757
41regulation of dendritic cell antigen processing and presentation (GO:0002604)3.19553009
42glutamate secretion (GO:0014047)3.19394685
43positive regulation of fibroblast migration (GO:0010763)3.18047289
44JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.15097244
45positive thymic T cell selection (GO:0045059)3.14590592
46nerve growth factor signaling pathway (GO:0038180)3.05335445
47myeloid cell activation involved in immune response (GO:0002275)3.04740956
48COPII vesicle coating (GO:0048208)3.03638915
49retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.02764095
50immunoglobulin mediated immune response (GO:0016064)3.01917054
51microglial cell activation (GO:0001774)3.01505829
52mature B cell differentiation involved in immune response (GO:0002313)3.00333210
53chaperone mediated protein folding requiring cofactor (GO:0051085)2.97875107
54positive regulation of mast cell activation (GO:0033005)2.94365236
55mast cell activation involved in immune response (GO:0002279)2.93972337
56mast cell degranulation (GO:0043303)2.93972337
57regulation of mast cell activation (GO:0033003)2.91938578
58positive regulation of mast cell degranulation (GO:0043306)2.90604545
59positive regulation of mast cell activation involved in immune response (GO:0033008)2.90604545
60positive regulation of Rap GTPase activity (GO:0032854)2.90120399
61regulation of mast cell degranulation (GO:0043304)2.90052925
62detection of molecule of bacterial origin (GO:0032490)2.89809446
63negative regulation of bone resorption (GO:0045779)2.89593462
64regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.88001447
65neutrophil activation (GO:0042119)2.87926460
66gamma-aminobutyric acid signaling pathway (GO:0007214)2.86326552
67activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.84627901
68respiratory burst (GO:0045730)2.84348158
69macrophage activation involved in immune response (GO:0002281)2.83400136
70mast cell activation (GO:0045576)2.82488493
71positive regulation of antigen processing and presentation (GO:0002579)2.82455842
72NADH metabolic process (GO:0006734)2.82161212
73leukocyte degranulation (GO:0043299)2.80416366
74regulation of mast cell activation involved in immune response (GO:0033006)2.80038950
75regulation of synaptic vesicle exocytosis (GO:2000300)2.79913401
76negative regulation of growth of symbiont in host (GO:0044130)2.78834749
77negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.78834749
78modulation of growth of symbiont involved in interaction with host (GO:0044144)2.78834749
79regulation of growth of symbiont in host (GO:0044126)2.78834749
80detection of other organism (GO:0098543)2.78390636
81regulation of short-term neuronal synaptic plasticity (GO:0048172)2.77789283
82synaptic vesicle docking involved in exocytosis (GO:0016081)2.76681057
83regulation of ARF protein signal transduction (GO:0032012)2.74038167
84killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.73225716
85disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.73225716
86actin nucleation (GO:0045010)2.72649388
87negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.72570313
88actin filament polymerization (GO:0030041)2.70657096
89interferon-gamma-mediated signaling pathway (GO:0060333)2.70128515
90complement activation, classical pathway (GO:0006958)2.69555919
91positive regulation of nuclease activity (GO:0032075)2.69124564
92regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.68412772
93sequestering of metal ion (GO:0051238)2.68092817
94positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.67890369
95regulation of platelet aggregation (GO:0090330)2.66024336
96regulation of Rap GTPase activity (GO:0032317)2.64777008
97regulation of synaptic vesicle transport (GO:1902803)2.64018875
98regulation of regulated secretory pathway (GO:1903305)2.62296428
99modulation by symbiont of host immune response (GO:0052553)2.62221168
100positive regulation by symbiont of host defense response (GO:0052509)2.62221168
101modulation by symbiont of host defense response (GO:0052031)2.62221168
102modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.62221168
103modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.62221168
104positive regulation by organism of defense response of other organism involved in symbiotic interact2.62221168
105UDP-N-acetylglucosamine metabolic process (GO:0006047)2.62008570
106granulocyte activation (GO:0036230)2.61542364
107negative regulation of interleukin-17 production (GO:0032700)2.61195655
108regulation of cholesterol homeostasis (GO:2000188)2.60287283
109positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.59805444
110germinal center formation (GO:0002467)2.59793926
111regulation of interleukin-12 biosynthetic process (GO:0045075)2.59231711
112negative regulation of synaptic transmission, GABAergic (GO:0032229)2.59040512
113relaxation of smooth muscle (GO:0044557)2.57684330
114positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.57432463
115vesicle coating (GO:0006901)2.57273436
116positive regulation of lamellipodium assembly (GO:0010592)2.56635762
117regulation of myeloid leukocyte mediated immunity (GO:0002886)2.55943201
118ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.55917130
119regulation of mitochondrial depolarization (GO:0051900)2.55705807
120ionotropic glutamate receptor signaling pathway (GO:0035235)2.55512641
121negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.54475517
122detection of external biotic stimulus (GO:0098581)2.52565595
123regulation of nuclease activity (GO:0032069)2.52322282
124regulation of T-helper 2 cell differentiation (GO:0045628)2.51786624
125amino acid import (GO:0043090)2.51387935
126phosphorelay signal transduction system (GO:0000160)2.51138656
127macrophage activation (GO:0042116)2.50751779
128positive regulation of histone deacetylation (GO:0031065)2.50672053
129response to interleukin-15 (GO:0070672)2.50073740
130positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.49419808
131cerebellar Purkinje cell differentiation (GO:0021702)2.48427544
132retinal cone cell development (GO:0046549)2.47986048
133long-chain fatty acid biosynthetic process (GO:0042759)2.47773012
134intestinal cholesterol absorption (GO:0030299)2.47060822
135detection of bacterium (GO:0016045)2.46647173
136regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.46556689
137long-term synaptic potentiation (GO:0060291)2.46268125
138response to type I interferon (GO:0034340)2.45929932
139positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.45272470
140regulation of leukocyte degranulation (GO:0043300)2.45268563
141negative regulation of erythrocyte differentiation (GO:0045647)2.44942918
142peptide catabolic process (GO:0043171)2.44407341
143negative regulation of cell killing (GO:0031342)2.43829775
144negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.43829775
145endoplasmic reticulum unfolded protein response (GO:0030968)2.43392844
146negative regulation of glycoprotein biosynthetic process (GO:0010561)2.42948124
147locomotory exploration behavior (GO:0035641)2.42432288
148proline biosynthetic process (GO:0006561)2.42428208
149regulation of female gonad development (GO:2000194)2.42271291
150NIK/NF-kappaB signaling (GO:0038061)2.41320162
151positive regulation of cell adhesion mediated by integrin (GO:0033630)2.41148116
152negative regulation of interleukin-12 production (GO:0032695)2.40850967
153positive regulation of interferon-alpha production (GO:0032727)2.39868032
154negative regulation of inclusion body assembly (GO:0090084)2.39762652
155cellular response to type I interferon (GO:0071357)2.39649894
156type I interferon signaling pathway (GO:0060337)2.39649894
157leukocyte aggregation (GO:0070486)2.39236635
158interleukin-6-mediated signaling pathway (GO:0070102)2.38060574
159neurotransmitter secretion (GO:0007269)2.36758548
160negative regulation of phagocytosis (GO:0050765)2.36584108
161toxin metabolic process (GO:0009404)2.36171478
162regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.35935639
163regulation of type I interferon-mediated signaling pathway (GO:0060338)2.35930770
164cellular response to unfolded protein (GO:0034620)2.35488617
165positive regulation of toll-like receptor signaling pathway (GO:0034123)2.34711044
166tricarboxylic acid metabolic process (GO:0072350)2.33265324
167positive regulation of lamellipodium organization (GO:1902745)2.33183552
168defense response to protozoan (GO:0042832)2.29431409
169cellular response to topologically incorrect protein (GO:0035967)2.29217912
170oxaloacetate metabolic process (GO:0006107)2.28401296
171negative regulation of B cell proliferation (GO:0030889)2.28368647
172positive regulation of triglyceride biosynthetic process (GO:0010867)2.28278881
173negative regulation of humoral immune response (GO:0002921)2.28240984
174regulation of interferon-alpha production (GO:0032647)2.27459557
175endocrine pancreas development (GO:0031018)2.27270978
176B cell proliferation (GO:0042100)2.26362405
177regulation of antigen processing and presentation (GO:0002577)2.25176329
178ER-nucleus signaling pathway (GO:0006984)2.25005605
179regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.23485032
180mannose metabolic process (GO:0006013)2.23103377

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.44813664
2EZH2_22144423_ChIP-Seq_EOC_Human4.37226886
3SMAD_19615063_ChIP-ChIP_OVARY_Human4.12412071
4MYC_22102868_ChIP-Seq_BL_Human3.16195117
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.14281754
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.03142836
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.97490807
8GBX2_23144817_ChIP-Seq_PC3_Human2.95177362
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.86015793
10E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.69615134
11* IRF8_21731497_ChIP-ChIP_J774_Mouse2.62622135
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.59688366
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.58017912
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.54674377
15* IRF8_27001747_Chip-Seq_BMDM_Mouse2.53680823
16* RXR_22158963_ChIP-Seq_LIVER_Mouse2.49710493
17* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.44501221
18VDR_21846776_ChIP-Seq_THP-1_Human2.41242590
19* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38466743
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.35634744
21* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31063273
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26579056
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.21405150
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.20815814
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08781565
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.05584437
27RUNX_20019798_ChIP-Seq_JUKART_Human2.03581245
28MAF_26560356_Chip-Seq_TH1_Human1.99182808
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.97499645
30VDR_24787735_ChIP-Seq_THP-1_Human1.95978672
31* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95036047
32UTX_26944678_Chip-Seq_JUKART_Human1.88555367
33SPI1_23127762_ChIP-Seq_K562_Human1.88399990
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.87811189
35* MYB_26560356_Chip-Seq_TH1_Human1.85858631
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85502879
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78223601
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78182812
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78182106
40GATA1_22025678_ChIP-Seq_K562_Human1.76881725
41LXR_22158963_ChIP-Seq_LIVER_Mouse1.75467637
42DROSHA_22980978_ChIP-Seq_HELA_Human1.74813885
43TCF7_22412390_ChIP-Seq_EML_Mouse1.74718498
44MYB_26560356_Chip-Seq_TH2_Human1.73893072
45SCL_19346495_ChIP-Seq_HPC-7_Human1.69363220
46LXR_22292898_ChIP-Seq_THP-1_Human1.67782060
47* VDR_24763502_ChIP-Seq_THP-1_Human1.66736096
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65181749
49PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64776371
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63909612
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.63494999
52* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61972958
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61195107
54* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.60862826
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.60201525
56KDM2B_26808549_Chip-Seq_DND41_Human1.59459923
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57692262
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55394910
59SPI1_23547873_ChIP-Seq_NB4_Human1.54118041
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.51542369
61REST_21632747_ChIP-Seq_MESCs_Mouse1.48652106
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46405955
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46014281
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.45637779
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45158333
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43333970
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42138159
68DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.39235129
69GATA3_27048872_Chip-Seq_THYMUS_Human1.38993540
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38120367
71FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.36595809
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36394940
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35694518
74TCF4_23295773_ChIP-Seq_U87_Human1.32457442
75GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32215199
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29765344
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.29676938
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29173278
79SMAD4_21799915_ChIP-Seq_A2780_Human1.27323668
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.26514718
81STAT3_23295773_ChIP-Seq_U87_Human1.25839595
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25101163
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22723738
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.21912589
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.21815010
86PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21438965
87TP53_16413492_ChIP-PET_HCT116_Human1.21243427
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19991218
89GATA1_19941826_ChIP-Seq_K562_Human1.19656693
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.18924276
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18499213
92STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18065050
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17610036
94IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17585948
95KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.17530232
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17314345
97FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.16955327
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16920309
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16802669
100NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16315316
101* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15681821
102TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15194218
103RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14482617
104SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14389858
105* PU_27001747_Chip-Seq_BMDM_Mouse1.14048725
106* MAF_26560356_Chip-Seq_TH2_Human1.11945323
107CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11694884
108GATA1_19941827_ChIP-Seq_MEL_Mouse1.11386803
109CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10308209
110GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09168269
111CIITA_25753668_ChIP-Seq_RAJI_Human1.09151456
112TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08735267
113NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08218967
114RACK7_27058665_Chip-Seq_MCF-7_Human1.08138769
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.07823174
116* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07816347
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05535004
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05423244
119CLOCK_20551151_ChIP-Seq_293T_Human1.04292934
120SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04022963
121NANOG_18555785_Chip-Seq_ESCs_Mouse1.04016033
122CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03086992
123LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02074608
124RARB_27405468_Chip-Seq_BRAIN_Mouse1.00940522
125TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00786531
126ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00687812
127TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99402981
128* BCOR_27268052_Chip-Seq_Bcells_Human0.99291982
129* BCL6_27268052_Chip-Seq_Bcells_Human0.98948766
130CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98800829
131SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98744366
132MTF2_20144788_ChIP-Seq_MESCs_Mouse0.98339093
133GATA2_19941826_ChIP-Seq_K562_Human0.98271581
134SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97893988
135TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97687447
136SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97297895
137POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97152602
138TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97152602
139GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95927003
140AR_25329375_ChIP-Seq_VCAP_Human0.95647507
141* SMRT_27268052_Chip-Seq_Bcells_Human0.95629195
142THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95613991
143GATA3_26560356_Chip-Seq_TH2_Human0.95302479
144* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95243580
145P300_19829295_ChIP-Seq_ESCs_Human0.95118383
146KDM2B_26808549_Chip-Seq_REH_Human0.94053934
147CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93883681
148TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93540508
149KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93386684
150NCOR1_26117541_ChIP-Seq_K562_Human0.93375226
151CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93115096
152P68_20966046_ChIP-Seq_HELA_Human0.93095913
153TAF15_26573619_Chip-Seq_HEK293_Human0.93023478
154SOX2_21211035_ChIP-Seq_LN229_Gbm0.92023446
155REST_18959480_ChIP-ChIP_MESCs_Mouse0.91994395
156FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91607918
157MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90962019
158LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90488786
159MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89767196
160NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88967308
161NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88967308
162E2F1_18555785_Chip-Seq_ESCs_Mouse0.88891100

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.88180947
2MP0001835_abnormal_antigen_presentation3.46978456
3MP0001790_abnormal_immune_system3.33959644
4MP0005387_immune_system_phenotype3.33959644
5MP0004859_abnormal_synaptic_plasticity3.10997172
6MP0003303_peritoneal_inflammation3.07584324
7MP0001800_abnormal_humoral_immune2.86348246
8MP0000685_abnormal_immune_system2.79583231
9MP0003300_gastrointestinal_ulcer2.78112814
10MP0003183_abnormal_peptide_metabolism2.76767879
11MP0000920_abnormal_myelination2.36545972
12MP0003690_abnormal_glial_cell2.34184746
13MP0003880_abnormal_central_pattern2.31711702
14MP0009840_abnormal_foam_cell2.30614729
15MP0002452_abnormal_antigen_presenting2.26969892
16MP0002138_abnormal_hepatobiliary_system2.25438678
17MP0005000_abnormal_immune_tolerance2.22138594
18MP0002064_seizures2.21096643
19MP0003635_abnormal_synaptic_transmissio2.13923638
20MP0003436_decreased_susceptibility_to2.11936663
21MP0009046_muscle_twitch2.08649577
22MP0001486_abnormal_startle_reflex2.04094753
23MP0005671_abnormal_response_to2.02956573
24MP0008877_abnormal_DNA_methylation2.02622713
25MP0002909_abnormal_adrenal_gland2.01805867
26MP0002723_abnormal_immune_serum2.00790171
27MP0002272_abnormal_nervous_system1.96524886
28MP0005360_urolithiasis1.93041317
29MP0002420_abnormal_adaptive_immunity1.91332156
30MP0005058_abnormal_lysosome_morphology1.91226617
31MP0003787_abnormal_imprinting1.88077430
32MP0000013_abnormal_adipose_tissue1.88022477
33MP0009745_abnormal_behavioral_response1.87681120
34MP0001819_abnormal_immune_cell1.87077011
35MP0000015_abnormal_ear_pigmentation1.85037524
36MP0005365_abnormal_bile_salt1.78444651
37MP0002419_abnormal_innate_immunity1.77239131
38MP0002735_abnormal_chemical_nociception1.75125215
39MP0005464_abnormal_platelet_physiology1.74829833
40MP0001501_abnormal_sleep_pattern1.74600242
41MP0008569_lethality_at_weaning1.73526556
42MP0002693_abnormal_pancreas_physiology1.71491880
43MP0003172_abnormal_lysosome_physiology1.70413459
44MP0004510_myositis1.70210931
45MP0002166_altered_tumor_susceptibility1.70119204
46MP0002139_abnormal_hepatobiliary_system1.70026827
47MP0005025_abnormal_response_to1.69611828
48MP0003866_abnormal_defecation1.68676754
49MP0004270_analgesia1.68660383
50MP0001845_abnormal_inflammatory_respons1.68522452
51MP0003195_calcinosis1.65266677
52MP0002398_abnormal_bone_marrow1.63735656
53MP0009785_altered_susceptibility_to1.63226946
54MP0005423_abnormal_somatic_nervous1.62497260
55MP0001986_abnormal_taste_sensitivity1.61850969
56MP0000716_abnormal_immune_system1.61326439
57MP0002063_abnormal_learning/memory/cond1.60841634
58MP0009643_abnormal_urine_homeostasis1.59047911
59MP0003329_amyloid_beta_deposits1.58980359
60MP0005174_abnormal_tail_pigmentation1.56953051
61MP0001545_abnormal_hematopoietic_system1.54734557
62MP0005397_hematopoietic_system_phenotyp1.54734557
63MP0003191_abnormal_cellular_cholesterol1.53455198
64MP0003633_abnormal_nervous_system1.53121733
65MP0008260_abnormal_autophagy1.52503082
66MP0009278_abnormal_bone_marrow1.51423958
67MP0004947_skin_inflammation1.48187601
68MP0001873_stomach_inflammation1.46664066
69MP0000689_abnormal_spleen_morphology1.46489203
70MP0002928_abnormal_bile_duct1.44737621
71MP0003252_abnormal_bile_duct1.44229735
72MP0001666_abnormal_nutrient_absorption1.41027879
73MP0003763_abnormal_thymus_physiology1.39449361
74MP0001958_emphysema1.39266798
75MP0002148_abnormal_hypersensitivity_rea1.38819503
76MP0002877_abnormal_melanocyte_morpholog1.37465524
77MP0005310_abnormal_salivary_gland1.36444259
78MP0010155_abnormal_intestine_physiology1.35313049
79MP0008057_abnormal_DNA_replication1.33622975
80MP0008875_abnormal_xenobiotic_pharmacok1.33224460
81MP0001968_abnormal_touch/_nociception1.32186041
82MP0002429_abnormal_blood_cell1.30355036
83MP0008874_decreased_physiological_sensi1.29930975
84MP0002405_respiratory_system_inflammati1.29583318
85MP0002572_abnormal_emotion/affect_behav1.29350014
86MP0000609_abnormal_liver_physiology1.28118095
87MP0008469_abnormal_protein_level1.27871314
88MP0003656_abnormal_erythrocyte_physiolo1.25662587
89MP0001944_abnormal_pancreas_morphology1.25602862
90MP0004147_increased_porphyrin_level1.25446162
91MP0003631_nervous_system_phenotype1.24702888
92MP0003724_increased_susceptibility_to1.23811702
93MP0002722_abnormal_immune_system1.22841689
94MP0001533_abnormal_skeleton_physiology1.21867590
95MP0002067_abnormal_sensory_capabilities1.21310224
96MP0001765_abnormal_ion_homeostasis1.20366230
97MP0006054_spinal_hemorrhage1.20172729
98MP0002136_abnormal_kidney_physiology1.18937418
99MP0005220_abnormal_exocrine_pancreas1.18842006
100MP0004264_abnormal_extraembryonic_tissu1.18830288
101MP0003075_altered_response_to1.18148159
102MP0001756_abnormal_urination1.16843033
103MP0003045_fibrosis1.15711713
104MP0004043_abnormal_pH_regulation1.14840368
105MP0006082_CNS_inflammation1.14704166
106MP0002078_abnormal_glucose_homeostasis1.13881627
107MP0009333_abnormal_splenocyte_physiolog1.13667028
108MP0010329_abnormal_lipoprotein_level1.12850019
109MP0000604_amyloidosis1.12477449
110MP0005386_behavior/neurological_phenoty1.12420183
111MP0004924_abnormal_behavior1.12420183
112MP0001970_abnormal_pain_threshold1.12315491
113MP0005085_abnormal_gallbladder_physiolo1.06968624
114MP0002396_abnormal_hematopoietic_system1.04970694
115MP0003566_abnormal_cell_adhesion1.02199945
116MP0001905_abnormal_dopamine_level1.01017194
117MP0005332_abnormal_amino_acid0.99571054
118MP0004811_abnormal_neuron_physiology0.99555434
119MP0001529_abnormal_vocalization0.99127702
120MP0005075_abnormal_melanosome_morpholog0.98943507
121MP0001851_eye_inflammation0.98735571
122MP0003868_abnormal_feces_composition0.97348756
123MP0002118_abnormal_lipid_homeostasis0.96323768
124MP0002734_abnormal_mechanical_nocicepti0.95775522
125MP0008961_abnormal_basal_metabolism0.95750101
126MP0003950_abnormal_plasma_membrane0.95646586
127MP0000465_gastrointestinal_hemorrhage0.95622713
128MP0002733_abnormal_thermal_nociception0.94836240
129MP0005670_abnormal_white_adipose0.94692370
130MP0005584_abnormal_enzyme/coenzyme_acti0.94169108
131MP0002933_joint_inflammation0.93833476
132MP0002229_neurodegeneration0.93327989
133MP0001440_abnormal_grooming_behavior0.90695134
134MP0003828_pulmonary_edema0.90578911
135MP0005319_abnormal_enzyme/_coenzyme0.89454125
136MP0002006_tumorigenesis0.88671620
137MP0000003_abnormal_adipose_tissue0.88501361
138MP0001879_abnormal_lymphatic_vessel0.87148923
139MP0003091_abnormal_cell_migration0.86202045
140MP0002822_catalepsy0.84772849
141MP0003632_abnormal_nervous_system0.84219322
142MP0004142_abnormal_muscle_tone0.84197362
143MP0004742_abnormal_vestibular_system0.83138364
144MP0003879_abnormal_hair_cell0.82576749
145MP0002066_abnormal_motor_capabilities/c0.81395777
146MP0005166_decreased_susceptibility_to0.81348493
147MP0002837_dystrophic_cardiac_calcinosis0.80847189
148MP0010386_abnormal_urinary_bladder0.80532441
149MP0002168_other_aberrant_phenotype0.79969081
150MP0001853_heart_inflammation0.79344575
151MP0009642_abnormal_blood_homeostasis0.78767842
152MP0004782_abnormal_surfactant_physiolog0.78537734
153MP0009764_decreased_sensitivity_to0.78447283
154MP0005023_abnormal_wound_healing0.77343742
155MP0000598_abnormal_liver_morphology0.74722018
156MP0002876_abnormal_thyroid_physiology0.73602189
157MP0010352_gastrointestinal_tract_polyps0.73458289
158MP0010234_abnormal_vibrissa_follicle0.71784906
159MP0000249_abnormal_blood_vessel0.70754830
160MP0004019_abnormal_vitamin_homeostasis0.70095138

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)4.75201609
2Colitis (HP:0002583)4.34580196
3Focal motor seizures (HP:0011153)4.24506164
4Abnormal delayed hypersensitivity skin test (HP:0002963)4.11027104
5Febrile seizures (HP:0002373)4.06172890
6Recurrent bronchitis (HP:0002837)3.80648868
7Papilledema (HP:0001085)3.79437384
8Gastrointestinal stroma tumor (HP:0100723)3.79142069
9Inflammation of the large intestine (HP:0002037)3.78367778
10Scanning speech (HP:0002168)3.76033469
11Gastrointestinal inflammation (HP:0004386)3.68258117
12Supranuclear gaze palsy (HP:0000605)3.58713882
13Action tremor (HP:0002345)3.55894313
14Diplopia (HP:0000651)3.49146262
15Abnormality of binocular vision (HP:0011514)3.49146262
16Mucopolysacchariduria (HP:0008155)3.43391655
17Urinary glycosaminoglycan excretion (HP:0003541)3.43391655
18IgM deficiency (HP:0002850)3.41210369
19Cellulitis (HP:0100658)3.39710880
20Focal seizures (HP:0007359)3.32148614
21Recurrent sinusitis (HP:0011108)3.28829569
22Atonic seizures (HP:0010819)3.27779093
23Abnormality of mucopolysaccharide metabolism (HP:0011020)3.25512722
24Abnormality of polysaccharide metabolism (HP:0011012)3.25512722
25Abnormality of glycosaminoglycan metabolism (HP:0004371)3.25512722
26Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.10540862
27Degeneration of the lateral corticospinal tracts (HP:0002314)3.10343926
28Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.10343926
29Dysostosis multiplex (HP:0000943)3.07045089
30Epileptic encephalopathy (HP:0200134)3.05035601
31Recurrent viral infections (HP:0004429)3.04707783
32Eczematoid dermatitis (HP:0000976)3.01446930
33Mitral stenosis (HP:0001718)2.98620783
34Myokymia (HP:0002411)2.94892988
35Decreased circulating renin level (HP:0003351)2.92318598
36Emphysema (HP:0002097)2.89897902
37Hyperventilation (HP:0002883)2.88176538
38Chronic otitis media (HP:0000389)2.86187801
39Chronic sinusitis (HP:0011109)2.85327035
40Spastic gait (HP:0002064)2.79933906
41Recurrent fungal infections (HP:0002841)2.79790306
42Meningitis (HP:0001287)2.76947755
43Autoimmune thrombocytopenia (HP:0001973)2.74020500
44Abnormality of T cell physiology (HP:0011840)2.73771455
45Papilloma (HP:0012740)2.73755263
46Verrucae (HP:0200043)2.73755263
47Bronchitis (HP:0012387)2.73124001
48Lymphopenia (HP:0001888)2.69981061
49Recurrent bacterial skin infections (HP:0005406)2.68960910
50Recurrent abscess formation (HP:0002722)2.67435554
51Vasculitis (HP:0002633)2.65675230
52Stomatitis (HP:0010280)2.65241240
53Abnormality of the corticospinal tract (HP:0002492)2.65076701
54Panhypogammaglobulinemia (HP:0003139)2.63460012
55Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.60249840
56Interstitial pulmonary disease (HP:0006530)2.59379320
57Lower limb muscle weakness (HP:0007340)2.58907341
58Abnormality of cells of the lymphoid lineage (HP:0012140)2.58260303
59Mutism (HP:0002300)2.55853597
60Progressive cerebellar ataxia (HP:0002073)2.54425786
61Postural instability (HP:0002172)2.54257132
62Chronic mucocutaneous candidiasis (HP:0002728)2.53361057
63Recurrent cutaneous fungal infections (HP:0011370)2.53361057
64Neurofibrillary tangles (HP:0002185)2.51846876
65Recurrent gram-negative bacterial infections (HP:0005420)2.50562358
66Delusions (HP:0000746)2.49620221
67Hypoglycemic coma (HP:0001325)2.48326807
68Restrictive lung disease (HP:0002091)2.48104747
69Spondylolisthesis (HP:0003302)2.46335401
70Dialeptic seizures (HP:0011146)2.46138382
71Dysmetria (HP:0001310)2.43958104
72Absence seizures (HP:0002121)2.43910691
73Prolonged bleeding time (HP:0003010)2.43821677
74Gaze-evoked nystagmus (HP:0000640)2.43121455
75Abnormal eating behavior (HP:0100738)2.41582393
76Nasal polyposis (HP:0100582)2.40205373
77Gout (HP:0001997)2.40154429
78Metaphyseal dysplasia (HP:0100255)2.39231069
79Peripheral hypomyelination (HP:0007182)2.38473732
80Episodic fever (HP:0001954)2.37667765
81Papillary thyroid carcinoma (HP:0002895)2.37355370
82Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.37027937
83Ankle clonus (HP:0011448)2.35888129
84Vacuolated lymphocytes (HP:0001922)2.32330439
85Osteomyelitis (HP:0002754)2.31158833
86Spontaneous hematomas (HP:0007420)2.27503312
87Dysdiadochokinesis (HP:0002075)2.26573316
88Orchitis (HP:0100796)2.25778756
89Obstructive lung disease (HP:0006536)2.25648144
90Chronic obstructive pulmonary disease (HP:0006510)2.25648144
91Global brain atrophy (HP:0002283)2.25320119
92Abnormality of the nasal mucosa (HP:0000433)2.25234486
93Myocardial infarction (HP:0001658)2.24893999
94Pustule (HP:0200039)2.24591358
95Periodontitis (HP:0000704)2.24433177
96Amyloidosis (HP:0011034)2.22400855
97Optic neuritis (HP:0100653)2.22148618
98Retrobulbar optic neuritis (HP:0100654)2.22148618
99Epistaxis (HP:0000421)2.21086974
100Recurrent skin infections (HP:0001581)2.18992868
101Visual hallucinations (HP:0002367)2.18700792
102Symptomatic seizures (HP:0011145)2.18028571
103Truncal ataxia (HP:0002078)2.17599246
104Diminished motivation (HP:0000745)2.16266727
105Pulmonary infiltrates (HP:0002113)2.16052791
106Loss of speech (HP:0002371)2.15456625
107Hypoglycemic seizures (HP:0002173)2.15018611
108Ocular albinism (HP:0001107)2.14699845
109Chronic diarrhea (HP:0002028)2.12753087
110Fatigue (HP:0012378)2.11897988
111Amyotrophic lateral sclerosis (HP:0007354)2.10632233
112Cerebral aneurysm (HP:0004944)2.09775259
113Mediastinal lymphadenopathy (HP:0100721)2.09717310
114Abnormality of macrophages (HP:0004311)2.09247395
115Large for gestational age (HP:0001520)2.09071650
116Memory impairment (HP:0002354)2.08917865
117Abnormality of T cells (HP:0002843)2.08668201
118Gingivitis (HP:0000230)2.06436908
119Neuronal loss in central nervous system (HP:0002529)2.06326202
120Hyperactive renin-angiotensin system (HP:0000841)2.05512878
121Increased cerebral lipofuscin (HP:0011813)2.04837514
122Limb dystonia (HP:0002451)2.04791194
123Pulmonary embolism (HP:0002204)2.04777584
124Apathy (HP:0000741)2.04579562
125Recurrent lower respiratory tract infections (HP:0002783)2.03881441
126Intention tremor (HP:0002080)2.03223176
127Elevated erythrocyte sedimentation rate (HP:0003565)2.02971388
128Hemoptysis (HP:0002105)2.02470629
129Hyperinsulinemic hypoglycemia (HP:0000825)2.00909295
130Torticollis (HP:0000473)1.99699129
131Abnormality of purine metabolism (HP:0004352)1.99341235
132IgA deficiency (HP:0002720)1.99310052
133Growth hormone excess (HP:0000845)1.97913811
134Recurrent otitis media (HP:0000403)1.97746275
135Absent speech (HP:0001344)1.97520010
136Generalized tonic-clonic seizures (HP:0002069)1.96327402
137Abnormality of aromatic amino acid family metabolism (HP:0004338)1.96258399
138Slow saccadic eye movements (HP:0000514)1.96076906
139Bradykinesia (HP:0002067)1.95942694
140Increased IgE level (HP:0003212)1.95263986
141Abnormality of renin-angiotensin system (HP:0000847)1.94794565
142Myositis (HP:0100614)1.94371473
143Ketoacidosis (HP:0001993)1.93930409
144Abnormality of small intestinal villus morphology (HP:0011472)1.93621452
145Villous atrophy (HP:0011473)1.93621452
146Abnormal platelet function (HP:0011869)1.92287196
147Impaired platelet aggregation (HP:0003540)1.92287196
148Gingival bleeding (HP:0000225)1.90347127
149Autoamputation (HP:0001218)1.89415307
150Sepsis (HP:0100806)1.89251305
151Limb hypertonia (HP:0002509)1.88833937
152Hypokalemia (HP:0002900)1.88413423
153Polycythemia (HP:0001901)1.87317383
154Hypoplasia of the thymus (HP:0000778)1.87074946
155Encephalitis (HP:0002383)1.87073438
156Cheilitis (HP:0100825)1.85456373
157Asymmetric septal hypertrophy (HP:0001670)1.85280979
158Abnormality of saccadic eye movements (HP:0000570)1.84680822
159Chest pain (HP:0100749)1.84346580
160Abnormality of calcium-phosphate metabolism (HP:0100530)1.83416397
161Iris hypopigmentation (HP:0007730)1.82814265
162Albinism (HP:0001022)1.82803135
163Xanthomatosis (HP:0000991)1.81716943
164B lymphocytopenia (HP:0010976)1.81683118
165Decreased motor nerve conduction velocity (HP:0003431)1.81310992
166Arterial thrombosis (HP:0004420)1.81271713
167Hyperglycemia (HP:0003074)1.80427315
168Paresthesia (HP:0003401)1.79969745
169Cerebral hypomyelination (HP:0006808)1.79308156
170Cerebral inclusion bodies (HP:0100314)1.79273921
171Rigidity (HP:0002063)1.79224110
172Hemiplegia (HP:0002301)1.76592419
173Insulin-resistant diabetes mellitus (HP:0000831)1.75943229
174Cervical subluxation (HP:0003308)1.73262403
175Ketosis (HP:0001946)1.73180657
176Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.72667568

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.27187612
2MAP4K14.85484402
3BMPR22.56622390
4BLK2.46402587
5MARK12.28728454
6TRIB32.24842487
7TYK22.20001113
8GRK62.18772202
9TAOK31.99046060
10BTK1.98003988
11JAK31.95962650
12FGFR41.91616662
13JAK11.90143079
14SYK1.86211167
15UHMK11.83033335
16ZAP701.81779459
17NTRK31.81446875
18CSF1R1.74889383
19MAP3K101.73862049
20FRK1.70681160
21MAP3K131.67926830
22PAK61.60648316
23PRPF4B1.59039237
24MAP3K121.54279144
25MAPK131.52355092
26LRRK21.50458886
27KSR21.50298276
28KIT1.48827563
29HIPK21.48490918
30INSRR1.46415907
31MAP3K141.45244664
32RIPK41.44518652
33CSK1.44443617
34TBK11.42642612
35TGFBR21.42616344
36DAPK21.36011195
37MAPK121.35109433
38ITK1.29978196
39IRAK41.29834861
40PKN21.28669224
41EPHB11.28586912
42FLT31.25409763
43STK101.24826628
44PTK61.24601047
45MAPK151.23589524
46EPHA31.22147574
47SIK11.21385128
48GRK51.18822514
49NTRK21.18513268
50SIK21.17357599
51PRKCH1.17162132
52TAOK11.17025708
53FES1.16671708
54CDK191.15660128
55MAP2K41.15222712
56PINK11.13507598
57WNK11.09738230
58SCYL21.09134603
59HCK1.08866356
60MAPK71.08039710
61MAP3K61.06030710
62MAP3K31.05152485
63BCKDK1.03374406
64CAMK1G1.01407181
65PTK2B1.00658412
66TEC1.00615171
67MINK11.00026934
68GRK70.99734445
69CDC42BPA0.97880686
70DYRK1B0.97102094
71IRAK30.96762324
72EPHA40.94715796
73RAF10.93381906
74TESK20.93275055
75CDK50.93085467
76KDR0.92112771
77CAMKK10.91321937
78DYRK1A0.90755785
79PRKD20.90404262
80LYN0.88884780
81MAP3K20.88247073
82SGK20.87001838
83MATK0.86800157
84LCK0.85609582
85JAK20.84793677
86PLK20.82230222
87MAP3K90.80326275
88MAP2K30.80012509
89MAP3K50.78512483
90CAMK1D0.77519436
91IKBKE0.77405507
92TRPM70.76653094
93MOS0.74444086
94MAP3K10.73438351
95PKN10.72686376
96PIK3CG0.72440831
97CAMK10.71319485
98RET0.70933224
99MARK30.70788330
100KSR10.70663625
101PTK20.70343480
102MAP3K40.70305718
103STK380.68750286
104TESK10.66532469
105RPS6KA40.66491489
106ALK0.65979143
107PASK0.65867082
108FGFR30.65159904
109TNK20.64417484
110NEK90.62898284
111FYN0.62593572
112PRKG20.61111548
113CAMKK20.58852392
114SGK4940.57323770
115SGK2230.57323770
116SGK10.57320375
117IRAK20.57067681
118MAP3K70.56395165
119PRKG10.55473722
120PDK10.55207085
121CAMK2A0.55073419
122CAMK2B0.54370761
123PRKAA10.54216749
124PRKD10.53364709
125FGR0.52599764
126MAPK100.52334912
127CASK0.51682702
128MAPK110.51251416
129OXSR10.51241121
130TTN0.50779018
131CAMK40.50538817
132SGK30.49200366
133GRK10.48992185
134CHUK0.48361904
135RIPK10.46895975
136MARK20.46795420
137ERBB30.46455452
138ABL10.46002810
139MAP4K20.46002180
140EGFR0.45718782
141MAP2K20.45312966
142MYLK0.44821641
143EEF2K0.44747820
144DYRK30.44666907
145EIF2AK30.44400952
146PDGFRA0.44358027
147PRKCD0.44177659
148PDPK10.43472700
149MAP3K110.40694921
150PRKCQ0.40393851
151NEK20.39043792
152IKBKB0.35800760
153MAPK40.35697825
154ARAF0.34051845

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.93550400
2Primary immunodeficiency_Homo sapiens_hsa053403.64571006
3B cell receptor signaling pathway_Homo sapiens_hsa046623.41350547
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.13964302
5Lysosome_Homo sapiens_hsa041422.08184171
6Synaptic vesicle cycle_Homo sapiens_hsa047212.05585937
7Long-term potentiation_Homo sapiens_hsa047202.01125633
8Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.00334667
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.99752487
10Nicotine addiction_Homo sapiens_hsa050331.96297741
11Antigen processing and presentation_Homo sapiens_hsa046121.79141723
12SNARE interactions in vesicular transport_Homo sapiens_hsa041301.71187066
13Morphine addiction_Homo sapiens_hsa050321.69812140
14Osteoclast differentiation_Homo sapiens_hsa043801.68967762
15GABAergic synapse_Homo sapiens_hsa047271.66299278
16Hematopoietic cell lineage_Homo sapiens_hsa046401.64791063
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.59979921
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.59349294
19Other glycan degradation_Homo sapiens_hsa005111.58863774
20Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.57163235
21Asthma_Homo sapiens_hsa053101.54575915
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.54103414
23Amphetamine addiction_Homo sapiens_hsa050311.52342151
24Circadian entrainment_Homo sapiens_hsa047131.51905464
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.50015226
26Glutamatergic synapse_Homo sapiens_hsa047241.45746196
27Leishmaniasis_Homo sapiens_hsa051401.45714770
28Tryptophan metabolism_Homo sapiens_hsa003801.43714298
29Staphylococcus aureus infection_Homo sapiens_hsa051501.37489575
30Dopaminergic synapse_Homo sapiens_hsa047281.36459810
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.34579889
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32950766
33Caffeine metabolism_Homo sapiens_hsa002321.30492046
34Dorso-ventral axis formation_Homo sapiens_hsa043201.29250869
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27993648
36Phospholipase D signaling pathway_Homo sapiens_hsa040721.27062278
37Type II diabetes mellitus_Homo sapiens_hsa049301.26898693
38Gastric acid secretion_Homo sapiens_hsa049711.25560422
39Graft-versus-host disease_Homo sapiens_hsa053321.20648208
40Tuberculosis_Homo sapiens_hsa051521.18210898
41Sphingolipid signaling pathway_Homo sapiens_hsa040711.16461458
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15565912
43Fat digestion and absorption_Homo sapiens_hsa049751.14520476
44Cholinergic synapse_Homo sapiens_hsa047251.12787972
45Insulin resistance_Homo sapiens_hsa049311.12302497
46Shigellosis_Homo sapiens_hsa051311.10946202
47Folate biosynthesis_Homo sapiens_hsa007901.10808818
48Salivary secretion_Homo sapiens_hsa049701.10743277
49GnRH signaling pathway_Homo sapiens_hsa049121.09112187
50Sulfur metabolism_Homo sapiens_hsa009201.08977707
51Histidine metabolism_Homo sapiens_hsa003401.08832973
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08220094
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06933606
54Oxytocin signaling pathway_Homo sapiens_hsa049211.06434153
55Allograft rejection_Homo sapiens_hsa053301.05846299
56Glioma_Homo sapiens_hsa052141.05436053
57ABC transporters_Homo sapiens_hsa020101.04944691
58Calcium signaling pathway_Homo sapiens_hsa040201.04686443
59Autoimmune thyroid disease_Homo sapiens_hsa053201.04530856
60N-Glycan biosynthesis_Homo sapiens_hsa005101.03105670
61Insulin secretion_Homo sapiens_hsa049111.01917534
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97080573
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96992055
64Cocaine addiction_Homo sapiens_hsa050300.95070004
65Chemokine signaling pathway_Homo sapiens_hsa040620.94513895
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93717637
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93588714
68Type I diabetes mellitus_Homo sapiens_hsa049400.93553260
69Collecting duct acid secretion_Homo sapiens_hsa049660.93409039
70Regulation of autophagy_Homo sapiens_hsa041400.92946013
71Non-small cell lung cancer_Homo sapiens_hsa052230.91890654
72cAMP signaling pathway_Homo sapiens_hsa040240.91705949
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91083046
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.90812584
75Estrogen signaling pathway_Homo sapiens_hsa049150.90485747
76Long-term depression_Homo sapiens_hsa047300.90447218
77Renin-angiotensin system_Homo sapiens_hsa046140.89932848
78Olfactory transduction_Homo sapiens_hsa047400.89455921
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89110325
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88859666
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88174926
82Starch and sucrose metabolism_Homo sapiens_hsa005000.87165070
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85832806
84Gap junction_Homo sapiens_hsa045400.85084470
85MAPK signaling pathway_Homo sapiens_hsa040100.84670826
86Complement and coagulation cascades_Homo sapiens_hsa046100.84498021
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.83214458
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82912314
89Malaria_Homo sapiens_hsa051440.82622311
90Renin secretion_Homo sapiens_hsa049240.82577004
91Rheumatoid arthritis_Homo sapiens_hsa053230.82432603
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81990782
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81399020
94Galactose metabolism_Homo sapiens_hsa000520.81251912
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79820339
96Vitamin digestion and absorption_Homo sapiens_hsa049770.79700233
97Fatty acid degradation_Homo sapiens_hsa000710.79519390
98Toxoplasmosis_Homo sapiens_hsa051450.78237456
99Legionellosis_Homo sapiens_hsa051340.78201185
100Measles_Homo sapiens_hsa051620.77530235
101Circadian rhythm_Homo sapiens_hsa047100.77506791
102Choline metabolism in cancer_Homo sapiens_hsa052310.77081734
103Pentose phosphate pathway_Homo sapiens_hsa000300.76842067
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76832511
105Ras signaling pathway_Homo sapiens_hsa040140.76222163
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75941205
107Taste transduction_Homo sapiens_hsa047420.75491336
108ErbB signaling pathway_Homo sapiens_hsa040120.75282744
109Selenocompound metabolism_Homo sapiens_hsa004500.75081195
110Nitrogen metabolism_Homo sapiens_hsa009100.73365343
111Serotonergic synapse_Homo sapiens_hsa047260.72439057
112Renal cell carcinoma_Homo sapiens_hsa052110.72412667
113Rap1 signaling pathway_Homo sapiens_hsa040150.72287207
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71435056
115Fructose and mannose metabolism_Homo sapiens_hsa000510.70872107
116Bile secretion_Homo sapiens_hsa049760.70291226
117Platelet activation_Homo sapiens_hsa046110.69209930
118Arginine biosynthesis_Homo sapiens_hsa002200.68416212
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67179946
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65948033
121beta-Alanine metabolism_Homo sapiens_hsa004100.65024940
122Oocyte meiosis_Homo sapiens_hsa041140.64276482
123Prolactin signaling pathway_Homo sapiens_hsa049170.63515860
124Endocytosis_Homo sapiens_hsa041440.63011879
125Influenza A_Homo sapiens_hsa051640.61851106
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61649106
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61548971
128Viral myocarditis_Homo sapiens_hsa054160.61132030
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61072076
130Lysine degradation_Homo sapiens_hsa003100.61051141
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60815972
132Pancreatic secretion_Homo sapiens_hsa049720.59372886
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59240230
134Inositol phosphate metabolism_Homo sapiens_hsa005620.58919748
135Phenylalanine metabolism_Homo sapiens_hsa003600.58753864
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.58344679
137Glycerolipid metabolism_Homo sapiens_hsa005610.58124278
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.58044324
139T cell receptor signaling pathway_Homo sapiens_hsa046600.57566980
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56272140
141Acute myeloid leukemia_Homo sapiens_hsa052210.54882868
142PPAR signaling pathway_Homo sapiens_hsa033200.54819426
143Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54594449
144Insulin signaling pathway_Homo sapiens_hsa049100.54437587
145Chronic myeloid leukemia_Homo sapiens_hsa052200.53463053
146Pancreatic cancer_Homo sapiens_hsa052120.53159610
147Apoptosis_Homo sapiens_hsa042100.52069403
148mTOR signaling pathway_Homo sapiens_hsa041500.51954544
149Hepatitis B_Homo sapiens_hsa051610.51633127
150Glucagon signaling pathway_Homo sapiens_hsa049220.51536826
151Butanoate metabolism_Homo sapiens_hsa006500.51362595
152Phagosome_Homo sapiens_hsa041450.50337483
153Jak-STAT signaling pathway_Homo sapiens_hsa046300.49866328
154Herpes simplex infection_Homo sapiens_hsa051680.48379660
155Thyroid hormone synthesis_Homo sapiens_hsa049180.47428007
156Vibrio cholerae infection_Homo sapiens_hsa051100.47012593
157VEGF signaling pathway_Homo sapiens_hsa043700.45762801
158Pertussis_Homo sapiens_hsa051330.45484704
159Protein export_Homo sapiens_hsa030600.45353606

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