PXDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.11601024
2L-phenylalanine catabolic process (GO:0006559)6.11601024
3L-phenylalanine metabolic process (GO:0006558)5.88203214
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.88203214
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.72087786
6negative regulation of fibrinolysis (GO:0051918)5.62452812
7aromatic amino acid family catabolic process (GO:0009074)5.57251569
8regulation of fibrinolysis (GO:0051917)5.18512549
9peptidyl-glutamic acid carboxylation (GO:0017187)5.17929480
10protein carboxylation (GO:0018214)5.17929480
11high-density lipoprotein particle remodeling (GO:0034375)5.12943562
12indole-containing compound catabolic process (GO:0042436)5.12062231
13indolalkylamine catabolic process (GO:0046218)5.12062231
14tryptophan catabolic process (GO:0006569)5.12062231
15alpha-linolenic acid metabolic process (GO:0036109)5.05195048
16kynurenine metabolic process (GO:0070189)4.92691871
17bile acid biosynthetic process (GO:0006699)4.90542097
18regulation of protein activation cascade (GO:2000257)4.80879292
19complement activation, alternative pathway (GO:0006957)4.78906818
20very-low-density lipoprotein particle assembly (GO:0034379)4.78871322
21tryptophan metabolic process (GO:0006568)4.78513211
22urea metabolic process (GO:0019627)4.75867514
23urea cycle (GO:0000050)4.75867514
24reverse cholesterol transport (GO:0043691)4.62812834
25glyoxylate metabolic process (GO:0046487)4.59881999
26regulation of complement activation (GO:0030449)4.53082617
27plasma lipoprotein particle assembly (GO:0034377)4.50426479
28regulation of cholesterol esterification (GO:0010872)4.49909325
29cysteine metabolic process (GO:0006534)4.49886228
30sulfur amino acid catabolic process (GO:0000098)4.49368512
31phospholipid efflux (GO:0033700)4.43020596
32acylglycerol homeostasis (GO:0055090)4.40608459
33triglyceride homeostasis (GO:0070328)4.40608459
34regulation of cholesterol homeostasis (GO:2000188)4.39466947
35regulation of triglyceride catabolic process (GO:0010896)4.38142326
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.32551192
37nitrogen cycle metabolic process (GO:0071941)4.31927498
38plasma lipoprotein particle clearance (GO:0034381)4.30533756
39negative regulation of sterol transport (GO:0032372)4.28409109
40negative regulation of cholesterol transport (GO:0032375)4.28409109
41plasma lipoprotein particle remodeling (GO:0034369)4.25887178
42protein-lipid complex remodeling (GO:0034368)4.25887178
43macromolecular complex remodeling (GO:0034367)4.25887178
44homocysteine metabolic process (GO:0050667)4.25299411
45bile acid metabolic process (GO:0008206)4.16974697
46protein-lipid complex assembly (GO:0065005)4.15101489
47serine family amino acid catabolic process (GO:0009071)4.05145210
48virion attachment to host cell (GO:0019062)4.03982364
49adhesion of symbiont to host cell (GO:0044650)4.03982364
50fibrinolysis (GO:0042730)4.03201101
51aromatic amino acid family metabolic process (GO:0009072)4.02926173
52skin morphogenesis (GO:0043589)4.01705902
53cholesterol efflux (GO:0033344)3.90711445
54cellular glucuronidation (GO:0052695)3.87145646
55positive regulation of fatty acid beta-oxidation (GO:0032000)3.85636698
56cell adhesion mediated by integrin (GO:0033627)3.80769445
57amino-acid betaine metabolic process (GO:0006577)3.80568943
58endodermal cell differentiation (GO:0035987)3.79780551
59tyrosine metabolic process (GO:0006570)3.79279723
60barbed-end actin filament capping (GO:0051016)3.76068242
61bile acid and bile salt transport (GO:0015721)3.74775068
62positive regulation of extracellular matrix organization (GO:1903055)3.74652989
63adhesion of symbiont to host (GO:0044406)3.71942618
64positive regulation of lipid catabolic process (GO:0050996)3.69930298
65indolalkylamine metabolic process (GO:0006586)3.68216915
66plasma lipoprotein particle organization (GO:0071827)3.67945753
67regulation of plasminogen activation (GO:0010755)3.67669869
68lysine catabolic process (GO:0006554)3.67467895
69lysine metabolic process (GO:0006553)3.67467895
70alpha-amino acid catabolic process (GO:1901606)3.66918921
71regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.66606011
72phospholipid homeostasis (GO:0055091)3.60393428
73regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.60063699
74protein-lipid complex subunit organization (GO:0071825)3.52755805
75complement activation, classical pathway (GO:0006958)3.52017306
76positive regulation of lipoprotein lipase activity (GO:0051006)3.51580283
77positive regulation of triglyceride lipase activity (GO:0061365)3.51580283
78amine catabolic process (GO:0009310)3.50251441
79cellular biogenic amine catabolic process (GO:0042402)3.50251441
80complement activation (GO:0006956)3.50187964
81regulation of bile acid biosynthetic process (GO:0070857)3.45858268
82coenzyme catabolic process (GO:0009109)3.45653891
83ethanol oxidation (GO:0006069)3.45381142
84protein heterotrimerization (GO:0070208)3.45272702
85negative regulation of lipase activity (GO:0060192)3.45179858
86collagen fibril organization (GO:0030199)3.45155333
87cholesterol homeostasis (GO:0042632)3.43159769
88low-density lipoprotein particle remodeling (GO:0034374)3.42798333
89cellular ketone body metabolic process (GO:0046950)3.39149904
90positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.38542801
91glutamate metabolic process (GO:0006536)3.38536041
92dicarboxylic acid biosynthetic process (GO:0043650)3.38299262
93protein activation cascade (GO:0072376)3.38062965
94drug catabolic process (GO:0042737)3.37780879
95imidazole-containing compound metabolic process (GO:0052803)3.37758950
96glucuronate metabolic process (GO:0019585)3.37693278
97uronic acid metabolic process (GO:0006063)3.37693278
98sterol homeostasis (GO:0055092)3.37112966
99benzene-containing compound metabolic process (GO:0042537)3.36524354
100lipoprotein metabolic process (GO:0042157)3.34450944
101cellular amino acid catabolic process (GO:0009063)3.32614177
102cellular modified amino acid catabolic process (GO:0042219)3.32130773
103acute-phase response (GO:0006953)3.30855386
104basement membrane organization (GO:0071711)3.30401556
105glycine metabolic process (GO:0006544)3.25095330
106arginine metabolic process (GO:0006525)3.25070905
107low-density lipoprotein particle clearance (GO:0034383)3.24853600
108positive regulation of fatty acid oxidation (GO:0046321)3.21689617
109regulation of fatty acid beta-oxidation (GO:0031998)3.19056733
110epoxygenase P450 pathway (GO:0019373)3.18753950
111negative regulation of protein activation cascade (GO:2000258)3.18632591
112apoptotic cell clearance (GO:0043277)3.17885832
113serine family amino acid metabolic process (GO:0009069)3.16675095
114positive regulation of endothelial cell apoptotic process (GO:2000353)3.16489577
115extracellular fibril organization (GO:0043206)3.15611826
116blood coagulation, intrinsic pathway (GO:0007597)3.15248548
117protein localization to endosome (GO:0036010)3.14601457
118stress fiber assembly (GO:0043149)3.11765830
119regulation of membrane protein ectodomain proteolysis (GO:0051043)3.10215893
120response to nitrosative stress (GO:0051409)3.09666954
121flavonoid metabolic process (GO:0009812)3.09629137
122cell migration involved in heart development (GO:0060973)3.07930621
123chondrocyte proliferation (GO:0035988)3.05944085
124retina vasculature morphogenesis in camera-type eye (GO:0061299)3.02111923
125fibril organization (GO:0097435)2.99797753
126substrate-dependent cell migration (GO:0006929)2.96298430
127wound healing, spreading of epidermal cells (GO:0035313)2.88804410
128vascular endothelial growth factor signaling pathway (GO:0038084)2.85779880
129negative regulation of fatty acid transport (GO:2000192)2.85507183
130collagen metabolic process (GO:0032963)2.83802866
131negative regulation of smooth muscle cell migration (GO:0014912)2.81344402
132hyaluronan catabolic process (GO:0030214)2.80757790
133keratan sulfate catabolic process (GO:0042340)2.77361647
134regulation of mononuclear cell migration (GO:0071675)2.76474430
135vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.73188922
136negative regulation of blood coagulation (GO:0030195)2.72480175
137negative regulation of hemostasis (GO:1900047)2.72480175
138negative regulation of coagulation (GO:0050819)2.72143099
139hemidesmosome assembly (GO:0031581)2.71754176
140collagen catabolic process (GO:0030574)2.69591971
141regulation of early endosome to late endosome transport (GO:2000641)2.69162383
142multicellular organismal macromolecule metabolic process (GO:0044259)2.67455177
143type B pancreatic cell proliferation (GO:0044342)2.65289036
144extracellular matrix disassembly (GO:0022617)2.64889221
145positive regulation of p38MAPK cascade (GO:1900745)2.64650843
146cell-substrate junction assembly (GO:0007044)2.62910192
147regulation of extracellular matrix disassembly (GO:0010715)2.62909342
148negative regulation of nitric oxide biosynthetic process (GO:0045019)2.61373012
149regulation of integrin-mediated signaling pathway (GO:2001044)2.60390235
150venous blood vessel morphogenesis (GO:0048845)2.58627771
151protein retention in ER lumen (GO:0006621)2.58574281
152multicellular organismal metabolic process (GO:0044236)2.56674880
153negative regulation of wound healing (GO:0061045)2.55461404
154regulation of extracellular matrix organization (GO:1903053)2.54331783
155positive regulation of blood coagulation (GO:0030194)2.54193950
156positive regulation of hemostasis (GO:1900048)2.54193950
157regulation of apoptotic cell clearance (GO:2000425)2.54044135
158maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.53532981
159positive regulation of blood vessel endothelial cell migration (GO:0043536)2.52480608
160pinocytosis (GO:0006907)2.51899528
161multicellular organismal catabolic process (GO:0044243)2.51783026
162positive regulation of astrocyte differentiation (GO:0048711)2.48734942
163epithelial cell-cell adhesion (GO:0090136)2.48137771
164extracellular matrix assembly (GO:0085029)2.47124343
165endothelial cell morphogenesis (GO:0001886)2.45200003
166positive regulation of coagulation (GO:0050820)2.44397821
167positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.43232875
168glial cell migration (GO:0008347)2.43005362
169positive regulation of receptor recycling (GO:0001921)2.41185931
170positive regulation of osteoblast proliferation (GO:0033690)2.38975331
171dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.37964719
172regulation of macrophage chemotaxis (GO:0010758)2.35123725
173regulation of endothelial cell apoptotic process (GO:2000351)2.34741964
174cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.34552615
175extracellular matrix organization (GO:0030198)2.32649523
176extracellular structure organization (GO:0043062)2.31581644
177negative regulation of lipid transport (GO:0032369)2.31289333
178wound healing, spreading of cells (GO:0044319)2.30887310
179platelet degranulation (GO:0002576)2.30859073
180endocytic recycling (GO:0032456)2.29886029
181peptidyl-proline hydroxylation (GO:0019511)2.29682292
182kidney mesenchyme development (GO:0072074)2.27927483
183glomerular basement membrane development (GO:0032836)2.27665144
184positive regulation of wound healing (GO:0090303)2.26986353
185cellular response to vitamin (GO:0071295)2.26259779
186response to magnesium ion (GO:0032026)2.25418840
187cell proliferation involved in metanephros development (GO:0072203)2.24702661

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.22809219
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.52537174
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.65338748
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.46809120
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.00360979
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.45760330
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.15836568
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.58866557
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.55143856
10CLOCK_20551151_ChIP-Seq_293T_Human2.95753083
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.42684710
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.36729349
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.19688266
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.16873570
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.16807383
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02944407
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89479665
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.84142661
19SMAD_19615063_ChIP-ChIP_OVARY_Human1.82290644
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77111085
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.72749586
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.67363148
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.66786466
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.62181491
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.51891030
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49752471
27GATA1_22025678_ChIP-Seq_K562_Human1.48773626
28FOXA2_19822575_ChIP-Seq_HepG2_Human1.48435816
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46739022
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46491255
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.42352551
32P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40798883
33* BRD4_25478319_ChIP-Seq_HGPS_Human1.39339583
34UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39051153
35UBF1/2_26484160_Chip-Seq_HMECs_Human1.36941996
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35803811
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33158319
38SMC1_22415368_ChIP-Seq_MEFs_Mouse1.32988634
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30382631
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29817676
41PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29676126
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29466007
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.29047281
44ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.29043705
45CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27685174
46KDM2B_26808549_Chip-Seq_K562_Human1.26391273
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24317123
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23842237
49FOXO3_23340844_ChIP-Seq_DLD1_Human1.22983056
50TP53_22127205_ChIP-Seq_IMR90_Human1.21762521
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21215197
52SMC3_22415368_ChIP-Seq_MEFs_Mouse1.15348843
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13701112
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13473585
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10525853
56HNF4A_19822575_ChIP-Seq_HepG2_Human1.09054113
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.08457407
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.07713517
59TP53_18474530_ChIP-ChIP_U2OS_Human1.06115938
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.04402248
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03303422
62CJUN_26792858_Chip-Seq_BT549_Human1.01891750
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01802524
64SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01601076
65GATA4_25053715_ChIP-Seq_YYC3_Human1.01507761
66SA1_22415368_ChIP-Seq_MEFs_Mouse1.00586809
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00229978
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00127418
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99916216
70EED_16625203_ChIP-ChIP_MESCs_Mouse0.98580584
71RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97764439
72EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97764439
73TP53_20018659_ChIP-ChIP_R1E_Mouse0.97254951
74NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96131883
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96131883
76CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95628172
77HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94915367
78ERG_21242973_ChIP-ChIP_JURKAT_Human0.94426492
79SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91974561
80TP53_23651856_ChIP-Seq_MEFs_Mouse0.91735699
81SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91656859
82JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91252887
83MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90928678
84ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90334063
85SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90296783
86SOX2_20726797_ChIP-Seq_SW620_Human0.88631679
87JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88156567
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88079577
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88001675
90GATA1_19941826_ChIP-Seq_K562_Human0.87912619
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87187450
92GATA2_19941826_ChIP-Seq_K562_Human0.86764862
93EGR1_19032775_ChIP-ChIP_M12_Human0.86543272
94BP1_19119308_ChIP-ChIP_Hs578T_Human0.85701903
95AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85623786
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84971029
97ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84549577
98CDX2_20551321_ChIP-Seq_CACO-2_Human0.83801180
99RUNX_20019798_ChIP-Seq_JUKART_Human0.83788632
100SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.83747979
101SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.83747979
102PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83197308
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82772205
104ZNF263_19887448_ChIP-Seq_K562_Human0.82486509
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82186543
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82016434
107ELK3_25401928_ChIP-Seq_HUVEC_Human0.81721674
108LXR_22292898_ChIP-Seq_THP-1_Human0.79456324
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.79054318
110FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78210841
111SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78028911
112RACK7_27058665_Chip-Seq_MCF-7_Human0.76587939
113TBX20_22080862_ChIP-Seq_HEART_Mouse0.75914520
114TBX20_22328084_ChIP-Seq_HEART_Mouse0.75914520
115SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.74866057
116RXRA_24833708_ChIP-Seq_LIVER_Mouse0.73751275
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72817763
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.69409143
119IRF8_27001747_Chip-Seq_BMDM_Mouse0.67345659
120STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.65939159
121ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.65553812
122EP300_21415370_ChIP-Seq_HL-1_Mouse0.65403942
123BCAT_22108803_ChIP-Seq_LS180_Human0.65267375
124VDR_24787735_ChIP-Seq_THP-1_Human0.65218126
125BRD4_27068464_Chip-Seq_AML-cells_Mouse0.63613913
126PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.63448067
127NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.62457491
128ATF3_27146783_Chip-Seq_COLON_Human0.59548068
129ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.58069723
130KDM2B_26808549_Chip-Seq_SUP-B15_Human0.57951592
131TP63_23658742_ChIP-Seq_EP156T_Human0.57726215
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.56200011
133CEBPB_22108803_ChIP-Seq_LS180_Human0.56140385
134WT1_19549856_ChIP-ChIP_CCG9911_Human0.55039672
135P63_26484246_Chip-Seq_KERATINOCYTES_Human0.53615759
136HTT_18923047_ChIP-ChIP_STHdh_Human0.53445063

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.38466147
2MP0005360_urolithiasis6.43185267
3MP0005085_abnormal_gallbladder_physiolo5.17757673
4MP0005365_abnormal_bile_salt5.12542074
5MP0008875_abnormal_xenobiotic_pharmacok4.36636845
6MP0003252_abnormal_bile_duct3.53705492
7MP0010329_abnormal_lipoprotein_level3.31915806
8MP0009840_abnormal_foam_cell3.19418954
9MP0003806_abnormal_nucleotide_metabolis3.00501329
10MP0005257_abnormal_intraocular_pressure2.99753710
11MP0002138_abnormal_hepatobiliary_system2.88729055
12MP0005503_abnormal_tendon_morphology2.79402359
13MP0005058_abnormal_lysosome_morphology2.58556713
14MP0005083_abnormal_biliary_tract2.41690190
15MP0003191_abnormal_cellular_cholesterol2.36105663
16MP0006054_spinal_hemorrhage2.26452720
17MP0003950_abnormal_plasma_membrane2.26392723
18MP0010368_abnormal_lymphatic_system2.24595106
19MP0005332_abnormal_amino_acid2.12007770
20MP0001666_abnormal_nutrient_absorption2.11320320
21MP0000609_abnormal_liver_physiology2.10299182
22MP0003705_abnormal_hypodermis_morpholog2.09478872
23MP0004019_abnormal_vitamin_homeostasis1.99261477
24MP0001542_abnormal_bone_strength1.88363917
25MP0005623_abnormal_meninges_morphology1.86624696
26MP0002118_abnormal_lipid_homeostasis1.83680568
27MP0003195_calcinosis1.56179594
28MP0005319_abnormal_enzyme/_coenzyme1.47244136
29MP0002254_reproductive_system_inflammat1.46054789
30MP0003941_abnormal_skin_development1.43460243
31MP0005508_abnormal_skeleton_morphology1.42969743
32MP0002877_abnormal_melanocyte_morpholog1.40557382
33MP0002896_abnormal_bone_mineralization1.39483462
34MP0003011_delayed_dark_adaptation1.38180481
35MP0003868_abnormal_feces_composition1.31417824
36MP0003724_increased_susceptibility_to1.29417467
37MP0008438_abnormal_cutaneous_collagen1.27672054
38MP0002998_abnormal_bone_remodeling1.25467240
39MP0009780_abnormal_chondrocyte_physiolo1.23760463
40MP0005584_abnormal_enzyme/coenzyme_acti1.22339930
41MP0003448_altered_tumor_morphology1.21974690
42MP0004858_abnormal_nervous_system1.19331435
43MP0000685_abnormal_immune_system1.17977572
44MP0009764_decreased_sensitivity_to1.17495624
45MP0000858_altered_metastatic_potential1.13457598
46MP0003828_pulmonary_edema1.11724111
47MP0000013_abnormal_adipose_tissue1.11629498
48MP0000751_myopathy1.11368107
49MP0001849_ear_inflammation1.11167598
50MP0009643_abnormal_urine_homeostasis1.11079427
51MP0000003_abnormal_adipose_tissue1.07526329
52MP0005390_skeleton_phenotype1.06257613
53MP0000598_abnormal_liver_morphology1.04701653
54MP0005387_immune_system_phenotype1.04315654
55MP0001790_abnormal_immune_system1.04315654
56MP0001879_abnormal_lymphatic_vessel1.03143119
57MP0003300_gastrointestinal_ulcer1.01579023
58MP0009763_increased_sensitivity_to1.01104704
59MP0003303_peritoneal_inflammation1.00282804
60MP0006082_CNS_inflammation1.00270825
61MP0005275_abnormal_skin_tensile0.98465343
62MP0001915_intracranial_hemorrhage0.98333645
63MP0004782_abnormal_surfactant_physiolog0.97967568
64MP0000604_amyloidosis0.96852474
65MP0005375_adipose_tissue_phenotype0.95013929
66MP0003566_abnormal_cell_adhesion0.94355527
67MP0010352_gastrointestinal_tract_polyps0.93949344
68MP0008469_abnormal_protein_level0.93814041
69MP0009697_abnormal_copulation0.92721811
70MP0010030_abnormal_orbit_morphology0.92280166
71MP0003329_amyloid_beta_deposits0.91517220
72MP0000249_abnormal_blood_vessel0.90946595
73MP0009384_cardiac_valve_regurgitation0.90375339
74MP0001764_abnormal_homeostasis0.90342948
75MP0002108_abnormal_muscle_morphology0.89649042
76MP0005023_abnormal_wound_healing0.89202976
77MP0005197_abnormal_uvea_morphology0.88316468
78MP0002060_abnormal_skin_morphology0.87660098
79MP0003172_abnormal_lysosome_physiology0.85026395
80MP0006138_congestive_heart_failure0.83729361
81MP0009053_abnormal_anal_canal0.82972980
82MP0005647_abnormal_sex_gland0.82866602
83MP0000733_abnormal_muscle_development0.82714438
84MP0005451_abnormal_body_composition0.81323530
85MP0003186_abnormal_redox_activity0.80480304
86MP0004947_skin_inflammation0.80202475
87MP0003453_abnormal_keratinocyte_physiol0.79486756
88MP0001958_emphysema0.79342048
89MP0003638_abnormal_response/metabolism_0.79275546
90MP0002168_other_aberrant_phenotype0.78096836
91MP0001614_abnormal_blood_vessel0.77627112
92MP0002136_abnormal_kidney_physiology0.77298904
93MP0001881_abnormal_mammary_gland0.76652563
94MP0003436_decreased_susceptibility_to0.75417327
95MP0004272_abnormal_basement_membrane0.75301432
96MP0001243_abnormal_dermal_layer0.74674600
97MP0005164_abnormal_response_to0.74328532
98MP0001853_heart_inflammation0.73369190
99MP0000749_muscle_degeneration0.72548548
100MP0004510_myositis0.71999698
101MP0009642_abnormal_blood_homeostasis0.71903348
102MP0005409_darkened_coat_color0.71743432
103MP0009765_abnormal_xenobiotic_induced0.70214962
104MP0009250_abnormal_appendicular_skeleto0.69900175
105MP0000163_abnormal_cartilage_morphology0.69898976
106MP0005167_abnormal_blood-brain_barrier0.69854389
107MP0000762_abnormal_tongue_morphology0.69677916
108MP0002295_abnormal_pulmonary_circulatio0.69146174
109MP0001299_abnormal_eye_distance/0.68026846
110MP0005666_abnormal_adipose_tissue0.67568927
111MP0005464_abnormal_platelet_physiology0.67211622
112MP0003795_abnormal_bone_structure0.67150997
113MP0004883_abnormal_blood_vessel0.66989148
114MP0002933_joint_inflammation0.66874101
115MP0002928_abnormal_bile_duct0.66134299
116MP0005334_abnormal_fat_pad0.66064203
117MP0008260_abnormal_autophagy0.65455488
118MP0001800_abnormal_humoral_immune0.65108122
119MP0002148_abnormal_hypersensitivity_rea0.64831420
120MP0002113_abnormal_skeleton_development0.64774766
121MP0001845_abnormal_inflammatory_respons0.64374560
122MP0002971_abnormal_brown_adipose0.64356141
123MP0005193_abnormal_anterior_eye0.64242251
124MP0005076_abnormal_cell_differentiation0.64213615
125MP0003634_abnormal_glial_cell0.64022119
126MP0002089_abnormal_postnatal_growth/wei0.63408189
127MP0002332_abnormal_exercise_endurance0.63039840
128MP0000343_altered_response_to0.61688164
129MP0003091_abnormal_cell_migration0.60311089
130MP0001533_abnormal_skeleton_physiology0.59769329
131MP0005408_hypopigmentation0.57830335
132MP0003279_aneurysm0.57763349
133MP0003075_altered_response_to0.56481135
134MP0005376_homeostasis/metabolism_phenot0.56237400
135MP0000767_abnormal_smooth_muscle0.55194752
136MP0002128_abnormal_blood_circulation0.54948733
137MP0009785_altered_susceptibility_to0.54823514
138MP0010155_abnormal_intestine_physiology0.53959293
139MP0005084_abnormal_gallbladder_morpholo0.53646132
140MP0010234_abnormal_vibrissa_follicle0.53036171
141MP0004130_abnormal_muscle_cell0.52983888
142MP0005670_abnormal_white_adipose0.51966754
143MP0000427_abnormal_hair_cycle0.51746674
144MP0003656_abnormal_erythrocyte_physiolo0.51723497
145MP0005595_abnormal_vascular_smooth0.51406262
146MP0005166_decreased_susceptibility_to0.51395111
147MP0002796_impaired_skin_barrier0.51234944
148MP0005165_increased_susceptibility_to0.50871458
149MP0003045_fibrosis0.50681734
150MP0003690_abnormal_glial_cell0.50627791

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.33019134
2Premature rupture of membranes (HP:0001788)6.36618977
3Intrahepatic cholestasis (HP:0001406)6.31962096
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.94101862
5Xanthomatosis (HP:0000991)5.85957279
6Hypobetalipoproteinemia (HP:0003563)5.83646074
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.80623117
8Prolonged partial thromboplastin time (HP:0003645)5.31503018
9Complement deficiency (HP:0004431)5.06849155
10Hyperlipoproteinemia (HP:0010980)4.78344444
11Hypolipoproteinemia (HP:0010981)4.54868200
12Joint hemorrhage (HP:0005261)4.32476153
13Abnormality of the common coagulation pathway (HP:0010990)4.14582242
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.12519378
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.10207731
16Hypoalphalipoproteinemia (HP:0003233)4.08766604
17Aortic dissection (HP:0002647)3.98425435
18Epidermoid cyst (HP:0200040)3.95177506
19Hyperammonemia (HP:0001987)3.87680848
20Vascular tortuosity (HP:0004948)3.84844233
21Abnormality of complement system (HP:0005339)3.78309765
22Aortic aneurysm (HP:0004942)3.71364255
23Vertebral compression fractures (HP:0002953)3.69918442
24Myocardial infarction (HP:0001658)3.62880232
25Atrophic scars (HP:0001075)3.57552351
26Fat malabsorption (HP:0002630)3.54711460
27Abnormality of glycolipid metabolism (HP:0010969)3.47127002
28Abnormality of liposaccharide metabolism (HP:0010968)3.47127002
29Abnormality of glycosphingolipid metabolism (HP:0004343)3.47127002
30Arterial tortuosity (HP:0005116)3.44243626
31Abnormality of sulfur amino acid metabolism (HP:0004339)3.41962358
32Hyperglycinuria (HP:0003108)3.30767428
33Ketosis (HP:0001946)3.28602056
34Hypercholesterolemia (HP:0003124)3.26110970
35Abnormality of aspartate family amino acid metabolism (HP:0010899)3.24295900
36Abnormality of the intrinsic pathway (HP:0010989)3.24135924
37Abnormality of methionine metabolism (HP:0010901)3.23403152
38Cervical subluxation (HP:0003308)3.23235459
39Hyperglycinemia (HP:0002154)3.21167575
40Ankle contracture (HP:0006466)3.20195270
41Abnormality of glycine metabolism (HP:0010895)3.17497617
42Abnormality of serine family amino acid metabolism (HP:0010894)3.17497617
43Soft skin (HP:0000977)3.16718327
44Hypoglycemic coma (HP:0001325)3.14092063
45Cerebral aneurysm (HP:0004944)3.01576336
46Neonatal short-limb short stature (HP:0008921)3.00882304
47Bladder diverticulum (HP:0000015)2.99981568
48Esophageal varix (HP:0002040)2.99566277
49Fragile skin (HP:0001030)2.97349744
50Spinal rigidity (HP:0003306)2.96428937
51Wormian bones (HP:0002645)2.91343988
52Hepatocellular carcinoma (HP:0001402)2.91204413
53Mitral stenosis (HP:0001718)2.85820851
54Spontaneous abortion (HP:0005268)2.81697815
55Vascular calcification (HP:0004934)2.81210762
56Abnormality of pyrimidine metabolism (HP:0004353)2.79721606
57Blue sclerae (HP:0000592)2.79537442
58Spondylolisthesis (HP:0003302)2.77548587
59Conjugated hyperbilirubinemia (HP:0002908)2.75849258
60Dysostosis multiplex (HP:0000943)2.75834098
61Follicular hyperkeratosis (HP:0007502)2.72367274
62Cardiovascular calcification (HP:0011915)2.69303365
63Systemic lupus erythematosus (HP:0002725)2.68251491
64Dilatation of the ascending aorta (HP:0005111)2.66875085
65Axonal loss (HP:0003447)2.65956941
66Shallow orbits (HP:0000586)2.65195500
67Polycythemia (HP:0001901)2.64684058
68Abnormality of dentin (HP:0010299)2.64442233
69Skin nodule (HP:0200036)2.63363657
70Abnormality of proline metabolism (HP:0010907)2.60929621
71Hydroxyprolinuria (HP:0003080)2.60929621
72Thrombophlebitis (HP:0004418)2.60520738
73Genu recurvatum (HP:0002816)2.57325989
74Abnormality of fatty-acid metabolism (HP:0004359)2.55841794
75Mucopolysacchariduria (HP:0008155)2.54591440
76Urinary glycosaminoglycan excretion (HP:0003541)2.54591440
77Increased density of long bones (HP:0006392)2.54196343
78Broad metatarsal (HP:0001783)2.52508057
79Steatorrhea (HP:0002570)2.51756641
80Abnormality of polysaccharide metabolism (HP:0011012)2.50797057
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.50797057
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.50797057
83Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.50723446
84Pulmonary embolism (HP:0002204)2.50466870
85Achilles tendon contracture (HP:0001771)2.49549003
86Amyloidosis (HP:0011034)2.44156537
87Type 1 muscle fiber predominance (HP:0003803)2.43578601
88Hyperbilirubinemia (HP:0002904)2.43015486
89Glomerulonephritis (HP:0000099)2.41114856
90Abnormality of nucleobase metabolism (HP:0010932)2.39690651
91Mitral valve prolapse (HP:0001634)2.39579311
92Nuclear cataract (HP:0100018)2.37117224
93Malnutrition (HP:0004395)2.35310587
94Joint stiffness (HP:0001387)2.34004925
95Mitral regurgitation (HP:0001653)2.33442198
96Ketoacidosis (HP:0001993)2.31648113
97Delayed CNS myelination (HP:0002188)2.26304645
98Aortic regurgitation (HP:0001659)2.25231022
99Aneurysm (HP:0002617)2.25160720
100Gingival bleeding (HP:0000225)2.22839996
101Back pain (HP:0003418)2.22634907
102Hyperextensible skin (HP:0000974)2.22354012
103Biconcave vertebral bodies (HP:0004586)2.22290955
104Spastic diplegia (HP:0001264)2.21079486
105Abnormal delivery (HP:0001787)2.20137663
106Neurofibrillary tangles (HP:0002185)2.19778517
107Pancreatitis (HP:0001733)2.19725698
108Abnormality of purine metabolism (HP:0004352)2.19675173
109Menorrhagia (HP:0000132)2.19670951
110Metabolic acidosis (HP:0001942)2.19218988
111Osteolytic defects of the hand bones (HP:0009699)2.18011180
112Osteolytic defects of the phalanges of the hand (HP:0009771)2.18011180
113Increased variability in muscle fiber diameter (HP:0003557)2.15972612
114Elbow flexion contracture (HP:0002987)2.14353509
115Increased connective tissue (HP:0009025)2.13222385
116Recurrent gram-negative bacterial infections (HP:0005420)2.12294450
117Ovoid vertebral bodies (HP:0003300)2.12093883
118Acanthocytosis (HP:0001927)2.11033719
119Vacuolated lymphocytes (HP:0001922)2.10673639
120Peritonitis (HP:0002586)2.10567857
121Nephritis (HP:0000123)2.09244327
122Abnormality of the acetabulum (HP:0003170)2.09081076
123Ulnar bowing (HP:0003031)2.06728535
124Hemorrhage of the eye (HP:0011885)2.06598337
125Thin bony cortex (HP:0002753)2.05734357
126Abnormal cartilage morphology (HP:0002763)2.04553214
127Increased mean platelet volume (HP:0011877)2.04433972
128Short nail (HP:0001799)2.04029505
129Persistence of primary teeth (HP:0006335)2.02097174
130Abnormality of serum amino acid levels (HP:0003112)1.99455159
131Abnormal gallbladder morphology (HP:0012437)1.99063744
132Mildly elevated creatine phosphokinase (HP:0008180)1.98306505
133Neonatal onset (HP:0003623)1.97885824
134Slender build (HP:0001533)1.97855847
135Hypochromic microcytic anemia (HP:0004840)1.97520877
136Stroke (HP:0001297)1.97151363
137Spontaneous hematomas (HP:0007420)1.96131209
138Joint laxity (HP:0001388)1.95503007
139Cholelithiasis (HP:0001081)1.95093964
140Distal lower limb muscle weakness (HP:0009053)1.94718138
141Natal tooth (HP:0000695)1.92879052
142Aortic valve stenosis (HP:0001650)1.91462347
143Right ventricular cardiomyopathy (HP:0011663)1.91356767
144Alopecia of scalp (HP:0002293)1.90863477
145Abnormal gallbladder physiology (HP:0012438)1.90467072
146Cholecystitis (HP:0001082)1.90467072
147Asymmetric septal hypertrophy (HP:0001670)1.89565267
148Abnormality of the Achilles tendon (HP:0005109)1.87561343
149Cerebral inclusion bodies (HP:0100314)1.87452473
150Nonimmune hydrops fetalis (HP:0001790)1.87381857
151Sensorimotor neuropathy (HP:0007141)1.86973435
152Wrist flexion contracture (HP:0001239)1.86760720
153Hypoglycemic seizures (HP:0002173)1.85816719
154Dicarboxylic aciduria (HP:0003215)1.84762030
155Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84762030
156Wide anterior fontanel (HP:0000260)1.84131602
157Upper limb amyotrophy (HP:0009129)1.83751365
158Distal upper limb amyotrophy (HP:0007149)1.83751365
159Protrusio acetabuli (HP:0003179)1.83310949
160Abnormal platelet volume (HP:0011876)1.82976887
161Coxa vara (HP:0002812)1.81926190
162Abnormality of carpal bone ossification (HP:0006257)1.81654266
163Keratoconjunctivitis sicca (HP:0001097)1.79405952
164Orchitis (HP:0100796)1.79265029
165Abnormality of skeletal muscle fiber size (HP:0012084)1.77054776
166Purpura (HP:0000979)1.76081993
167Generalized amyotrophy (HP:0003700)1.75568993
168Hypoplasia of the iris (HP:0007676)1.73944840
169Abnormality of iron homeostasis (HP:0011031)1.73940937
170Femoral bowing (HP:0002980)1.73761049
171Rickets (HP:0002748)1.72992358
172Bowel diverticulosis (HP:0005222)1.72892126
173Overgrowth (HP:0001548)1.72775724
174Ectopia lentis (HP:0001083)1.71920451
175Venous abnormality (HP:0002624)1.71666620
176Abnormality of transition element cation homeostasis (HP:0011030)1.70062590
177Gout (HP:0001997)1.69832331
178Joint swelling (HP:0001386)1.68769230
179Enlarged kidneys (HP:0000105)1.66862577
180Interstitial pulmonary disease (HP:0006530)1.66645680

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.96406773
2SIK13.75470304
3ERN13.70265194
4FGFR43.50030944
5BCKDK2.82225991
6TRIB32.70672335
7MAPK152.69793258
8IRAK32.68330497
9LATS22.32364400
10TESK12.26393792
11TGFBR22.20100809
12JAK12.04080006
13PKN22.02932167
14PIM22.01990363
15EPHB11.96477895
16MAP3K141.93692837
17TBK11.88661696
18MOS1.83414620
19TIE11.82340347
20PTK61.80230490
21LATS11.72416934
22MAP4K11.65961519
23LIMK11.64105422
24ERBB41.62320178
25NTRK11.61441159
26TAOK21.57636521
27EPHA31.57391836
28CDC42BPA1.57351006
29NME21.54892306
30MAP3K31.54583961
31TYK21.51440647
32ICK1.50588024
33GRK61.50532233
34KDR1.48705204
35MST1R1.41412037
36ARAF1.29515593
37GRK71.26449369
38PTK21.20449130
39GSK3A1.18172008
40RIPK11.17980527
41LRRK21.16718190
42PRPF4B1.13309959
43BMX1.12265247
44FGFR31.10847171
45CSK1.10280408
46NEK91.08473194
47MAP2K31.08124243
48EPHA21.07980233
49STK241.07777668
50CHUK1.06999057
51PRKD21.06229165
52DMPK1.06149739
53EPHB21.01678568
54STK380.99782232
55INSRR0.99546703
56FRK0.97677261
57GRK10.97070453
58PIK3CG0.97030486
59IKBKB0.96897803
60TXK0.96791066
61PRKAA20.95849703
62ITK0.94958670
63DAPK30.94083748
64ILK0.91301091
65IKBKE0.89411155
66MAPKAPK30.89385369
67PDGFRA0.89258701
68MAP3K60.88636179
69MAP3K70.83841264
70TRPM70.83621379
71CDK60.83116557
72MAPK110.80849792
73JAK20.80518797
74FER0.79578630
75STK100.79113814
76ROCK20.76614537
77TTN0.76545701
78ROCK10.76378674
79MAP3K10.73236538
80MAP3K120.72712390
81LMTK20.72243079
82BTK0.72046230
83RPS6KA20.71629926
84TEC0.71582571
85MAP3K100.69977614
86FLT30.69932246
87ZAP700.69710350
88ABL20.69429998
89PDGFRB0.69201221
90JAK30.66982983
91DDR20.66739588
92MTOR0.65923653
93RPS6KA40.63957381
94FGFR20.63254013
95CSF1R0.63027392
96ERBB20.61661020
97TYRO30.61037080
98PRKCQ0.60380185
99IGF1R0.57897035
100PAK20.56739919
101RET0.55277284
102TAOK10.55248939
103DYRK1B0.55055660
104EEF2K0.54912631
105MAP2K40.54579505
106PIM10.54538662
107PRKCZ0.54328814
108MYLK0.54272852
109MAPK40.53861530
110STK38L0.53455056
111MAPK70.52825635
112PDPK10.52806778
113STK30.52454173
114MAP3K110.51708412
115MET0.51135101
116AKT30.50830824
117PRKD10.50018009
118PRKG20.49873292
119PDK20.48392411
120MAP2K20.48377051
121MAPK120.46797479
122PTK2B0.45331466
123KSR20.45254237
124CAMK2G0.44740115
125SMG10.44402324
126INSR0.44364242
127MAP2K10.44256380
128HCK0.44134677
129ABL10.42702723
130MAP3K20.41244993
131KIT0.40334013
132NLK0.40206713
133TGFBR10.39189874
134PRKCH0.38546071
135PAK40.37510864
136MAP3K130.37318892
137CAMK1D0.37093851
138PRKD30.35813338
139PAK60.35783851
140MAP3K50.35360879
141RPS6KL10.33595597
142RPS6KC10.33595597
143SRC0.32094898
144MAPKAPK20.31881895
145MATK0.31424015

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.37714262
2Nitrogen metabolism_Homo sapiens_hsa009103.54102951
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.39437577
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.22627061
5Complement and coagulation cascades_Homo sapiens_hsa046102.97933916
6Arginine biosynthesis_Homo sapiens_hsa002202.90984510
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.83866256
8Other glycan degradation_Homo sapiens_hsa005112.83619316
9Tryptophan metabolism_Homo sapiens_hsa003802.71529076
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.56359646
11Fatty acid degradation_Homo sapiens_hsa000712.55388048
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.23563992
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.17160359
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14293057
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.13293224
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.12614083
17PPAR signaling pathway_Homo sapiens_hsa033202.11786841
18Lysosome_Homo sapiens_hsa041421.96514790
19Chemical carcinogenesis_Homo sapiens_hsa052041.94380698
20Staphylococcus aureus infection_Homo sapiens_hsa051501.92522129
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.91192618
22Caffeine metabolism_Homo sapiens_hsa002321.88456384
23Peroxisome_Homo sapiens_hsa041461.87681159
24Fatty acid metabolism_Homo sapiens_hsa012121.86627768
25Retinol metabolism_Homo sapiens_hsa008301.85639386
26Butanoate metabolism_Homo sapiens_hsa006501.78712669
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.76870239
28Histidine metabolism_Homo sapiens_hsa003401.73477207
29Propanoate metabolism_Homo sapiens_hsa006401.60797779
30beta-Alanine metabolism_Homo sapiens_hsa004101.54522389
31Bile secretion_Homo sapiens_hsa049761.49600061
32Fat digestion and absorption_Homo sapiens_hsa049751.48480216
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.48387714
34Selenocompound metabolism_Homo sapiens_hsa004501.46890189
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45437058
36Phenylalanine metabolism_Homo sapiens_hsa003601.45321228
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.41220728
38Fatty acid elongation_Homo sapiens_hsa000621.29329494
39Proteoglycans in cancer_Homo sapiens_hsa052051.29259903
40Protein digestion and absorption_Homo sapiens_hsa049741.28820338
41Starch and sucrose metabolism_Homo sapiens_hsa005001.28407054
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27180929
43Tyrosine metabolism_Homo sapiens_hsa003501.22702246
44Sulfur metabolism_Homo sapiens_hsa009201.17345743
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17114747
46Salmonella infection_Homo sapiens_hsa051321.16534998
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14486536
48ABC transporters_Homo sapiens_hsa020101.09697518
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06194695
50Pyruvate metabolism_Homo sapiens_hsa006201.02301702
51Arginine and proline metabolism_Homo sapiens_hsa003301.01783832
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01345934
53Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97377585
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95803890
55Vitamin digestion and absorption_Homo sapiens_hsa049770.95341992
56Steroid biosynthesis_Homo sapiens_hsa001000.92785223
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.91567291
58Sphingolipid metabolism_Homo sapiens_hsa006000.90919375
59Dilated cardiomyopathy_Homo sapiens_hsa054140.88917050
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87593696
61Folate biosynthesis_Homo sapiens_hsa007900.85994540
62Carbon metabolism_Homo sapiens_hsa012000.85475534
63Biosynthesis of amino acids_Homo sapiens_hsa012300.84275955
64Vibrio cholerae infection_Homo sapiens_hsa051100.83252727
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82081228
66Phagosome_Homo sapiens_hsa041450.81878178
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81774020
68Rheumatoid arthritis_Homo sapiens_hsa053230.81737835
69Glutathione metabolism_Homo sapiens_hsa004800.77602697
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77279307
71Adherens junction_Homo sapiens_hsa045200.76506565
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75850173
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75660937
74Lysine degradation_Homo sapiens_hsa003100.75383163
75PI3K-Akt signaling pathway_Homo sapiens_hsa041510.75019222
76Sulfur relay system_Homo sapiens_hsa041220.74843146
77Mineral absorption_Homo sapiens_hsa049780.73695593
78Shigellosis_Homo sapiens_hsa051310.73360090
79Fatty acid biosynthesis_Homo sapiens_hsa000610.73134603
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73053741
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72914507
82Glycerolipid metabolism_Homo sapiens_hsa005610.72575805
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.71848574
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71625359
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71199078
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.66641284
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64649956
88Chronic myeloid leukemia_Homo sapiens_hsa052200.63726163
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62486325
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.61263744
91Hepatitis C_Homo sapiens_hsa051600.56137506
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56076991
93African trypanosomiasis_Homo sapiens_hsa051430.55294903
94TGF-beta signaling pathway_Homo sapiens_hsa043500.54847685
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.53233925
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.52008027
97Insulin resistance_Homo sapiens_hsa049310.50776882
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50701896
99Renal cell carcinoma_Homo sapiens_hsa052110.49487975
100Notch signaling pathway_Homo sapiens_hsa043300.47821272
101Prion diseases_Homo sapiens_hsa050200.46931186
102Endocytosis_Homo sapiens_hsa041440.46889434
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.45564973
104Pancreatic cancer_Homo sapiens_hsa052120.44014289
105Pathways in cancer_Homo sapiens_hsa052000.43456210
106Tuberculosis_Homo sapiens_hsa051520.43244555
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.43106270
108MicroRNAs in cancer_Homo sapiens_hsa052060.42581754
109ECM-receptor interaction_Homo sapiens_hsa045120.40725796
110One carbon pool by folate_Homo sapiens_hsa006700.39015890
111Leishmaniasis_Homo sapiens_hsa051400.38908696
112Pentose phosphate pathway_Homo sapiens_hsa000300.38522516
113VEGF signaling pathway_Homo sapiens_hsa043700.38188293
114Melanoma_Homo sapiens_hsa052180.37892384
115Rap1 signaling pathway_Homo sapiens_hsa040150.37703421
116Vitamin B6 metabolism_Homo sapiens_hsa007500.37624313
117Apoptosis_Homo sapiens_hsa042100.35825941
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34825660
119Tight junction_Homo sapiens_hsa045300.34474694
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.31793264
121Circadian rhythm_Homo sapiens_hsa047100.26630678
122Osteoclast differentiation_Homo sapiens_hsa043800.25445358
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.21826216
124Metabolic pathways_Homo sapiens_hsa011000.20898502
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19129121
126TNF signaling pathway_Homo sapiens_hsa046680.18729691
127Amoebiasis_Homo sapiens_hsa051460.18697222
128Galactose metabolism_Homo sapiens_hsa000520.18131626
129Focal adhesion_Homo sapiens_hsa045100.13497430
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.10549567
131Toxoplasmosis_Homo sapiens_hsa051450.10296205
132Glucagon signaling pathway_Homo sapiens_hsa049220.08571586
133B cell receptor signaling pathway_Homo sapiens_hsa046620.08242228
134Malaria_Homo sapiens_hsa051440.08020509
135Small cell lung cancer_Homo sapiens_hsa052220.07801917
136Bladder cancer_Homo sapiens_hsa052190.07686038
137Fructose and mannose metabolism_Homo sapiens_hsa000510.07293691
138AMPK signaling pathway_Homo sapiens_hsa041520.06499068
139Prolactin signaling pathway_Homo sapiens_hsa049170.05976295
140Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.05042533
141Ovarian steroidogenesis_Homo sapiens_hsa049130.04536905
142Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.03744245
143AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.02434931
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.01282392
145Renin-angiotensin system_Homo sapiens_hsa046140.00609217
146Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.00229010
147Hematopoietic cell lineage_Homo sapiens_hsa04640-0.0031145
148Pertussis_Homo sapiens_hsa05133-0.0021323

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »