PVRIG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive thymic T cell selection (GO:0045059)7.42606290
2cellular response to interleukin-15 (GO:0071350)7.38590243
3negative thymic T cell selection (GO:0045060)6.95373652
4response to interleukin-15 (GO:0070672)6.91866297
5positive regulation of gamma-delta T cell activation (GO:0046645)6.74645474
6negative T cell selection (GO:0043383)6.70704181
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.60662076
8negative regulation of cell killing (GO:0031342)6.60662076
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.45125765
10leukocyte aggregation (GO:0070486)6.41202568
11thymic T cell selection (GO:0045061)6.36272298
12regulation of T cell tolerance induction (GO:0002664)6.04634859
13interferon-gamma production (GO:0032609)5.98874068
14regulation of natural killer cell mediated immunity (GO:0002715)5.82818937
15regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.82818937
16regulation of gamma-delta T cell differentiation (GO:0045586)5.80629913
17positive T cell selection (GO:0043368)5.74836315
18regulation of B cell receptor signaling pathway (GO:0050855)5.54199239
19sequestering of actin monomers (GO:0042989)5.41715869
20positive regulation of type I interferon-mediated signaling pathway (GO:0060340)5.33333904
21T cell costimulation (GO:0031295)5.28308565
22regulation of isotype switching to IgG isotypes (GO:0048302)5.24155662
23lymphocyte costimulation (GO:0031294)5.23578099
24positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.20939009
25positive regulation of natural killer cell mediated immunity (GO:0002717)5.20939009
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.17487730
27regulation of gamma-delta T cell activation (GO:0046643)5.16834577
28T cell selection (GO:0045058)5.16224093
29T cell migration (GO:0072678)5.14473108
30positive regulation of tolerance induction (GO:0002645)5.11744639
31regulation of leukocyte mediated cytotoxicity (GO:0001910)4.75876618
32T cell receptor signaling pathway (GO:0050852)4.53570638
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.52519869
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.52519869
35regulation of tolerance induction (GO:0002643)4.49313501
36positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.46215058
37regulation of monocyte differentiation (GO:0045655)4.31816183
38regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.30578971
39cellular extravasation (GO:0045123)4.26699807
40regulation of cell killing (GO:0031341)4.26217997
41positive regulation of B cell differentiation (GO:0045579)4.25216536
42antigen receptor-mediated signaling pathway (GO:0050851)4.19375052
43tolerance induction (GO:0002507)4.13524020
44positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.13465567
45regulation of response to interferon-gamma (GO:0060330)4.10553517
46cytidine metabolic process (GO:0046087)4.07087864
47cytidine catabolic process (GO:0006216)4.07087864
48cytidine deamination (GO:0009972)4.07087864
49natural killer cell activation (GO:0030101)4.04669357
50regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.04139585
51negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.00933285
52antigen processing and presentation of endogenous antigen (GO:0019883)3.98537947
53regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.92649431
54negative regulation of T cell mediated immunity (GO:0002710)3.91223457
55regulation of T cell receptor signaling pathway (GO:0050856)3.87691454
56cellular defense response (GO:0006968)3.87650388
57positive regulation of cell killing (GO:0031343)3.86003222
58regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.82872033
59regulation of immunoglobulin mediated immune response (GO:0002889)3.82148997
60pyrimidine ribonucleoside catabolic process (GO:0046133)3.77227229
61positive regulation of alpha-beta T cell proliferation (GO:0046641)3.74451480
62negative regulation of T cell receptor signaling pathway (GO:0050860)3.73116408
63regulation of B cell mediated immunity (GO:0002712)3.72463283
64regulation of B cell differentiation (GO:0045577)3.71614690
65positive regulation of lamellipodium assembly (GO:0010592)3.69179113
66antigen processing and presentation via MHC class Ib (GO:0002475)3.67995327
67regulation of type I interferon-mediated signaling pathway (GO:0060338)3.65238001
68leukocyte cell-cell adhesion (GO:0007159)3.65106638
69negative regulation of leukocyte mediated immunity (GO:0002704)3.63012362
70regulation of T cell mediated cytotoxicity (GO:0001914)3.60316060
71regulation of interleukin-12 biosynthetic process (GO:0045075)3.59226669
72regulation of alpha-beta T cell proliferation (GO:0046640)3.55607785
73positive regulation of immunoglobulin mediated immune response (GO:0002891)3.55546625
74positive regulation of B cell mediated immunity (GO:0002714)3.55546625
75positive regulation of humoral immune response (GO:0002922)3.51718735
76positive regulation of granulocyte differentiation (GO:0030854)3.51427446
77heterotypic cell-cell adhesion (GO:0034113)3.50202313
78regulation of lymphocyte mediated immunity (GO:0002706)3.49013726
79immunoglobulin mediated immune response (GO:0016064)3.46050561
80negative regulation of T cell apoptotic process (GO:0070233)3.42571890
81regulation of isotype switching (GO:0045191)3.41146502
82regulation of regulatory T cell differentiation (GO:0045589)3.40279814
83B cell receptor signaling pathway (GO:0050853)3.39119251
84mast cell activation (GO:0045576)3.38928269
85regulation of activation of Janus kinase activity (GO:0010533)3.35274701
86regulation of interleukin-2 biosynthetic process (GO:0045076)3.34591618
87mucosal-associated lymphoid tissue development (GO:0048537)3.33739307
88positive regulation of macrophage differentiation (GO:0045651)3.32617403
89DNA deamination (GO:0045006)3.32183210
90positive regulation of lamellipodium organization (GO:1902745)3.29784416
91positive regulation of T cell mediated cytotoxicity (GO:0001916)3.29600567
92regulation of immunoglobulin production (GO:0002637)3.27978953
93B cell mediated immunity (GO:0019724)3.27943423
94negative regulation of phagocytosis (GO:0050765)3.27896242
95Arp2/3 complex-mediated actin nucleation (GO:0034314)3.25784937
96regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.25467599
97positive regulation of calcium-mediated signaling (GO:0050850)3.23980729
98negative regulation of interleukin-12 production (GO:0032695)3.22863969
99positive regulation of T cell mediated immunity (GO:0002711)3.20595071
100homeostasis of number of cells within a tissue (GO:0048873)3.20140534
101positive regulation of lymphocyte mediated immunity (GO:0002708)3.19952437
102dendritic cell chemotaxis (GO:0002407)3.19795938
103detection of bacterium (GO:0016045)3.18804834
104negative regulation of lymphocyte mediated immunity (GO:0002707)3.17222821
105lymphocyte migration (GO:0072676)3.16575568
106regulation of T cell mediated immunity (GO:0002709)3.16406533
107regulation of response to tumor cell (GO:0002834)3.14511961
108positive regulation of response to tumor cell (GO:0002836)3.14511961
109positive regulation of immune response to tumor cell (GO:0002839)3.14511961
110regulation of immune response to tumor cell (GO:0002837)3.14511961
111T cell activation (GO:0042110)3.13162035
112neutrophil activation (GO:0042119)3.12611007
113negative regulation of viral genome replication (GO:0045071)3.12027979
114activated T cell proliferation (GO:0050798)3.11863993
115lymph node development (GO:0048535)3.11820185
116positive regulation of interleukin-2 production (GO:0032743)3.11540634
117regulation of alpha-beta T cell activation (GO:0046634)3.11207141
118regulation of defense response to virus by virus (GO:0050690)3.10193553
119response to type I interferon (GO:0034340)3.10077932
120positive regulation of interleukin-4 production (GO:0032753)3.09977539
121negative regulation of myeloid cell apoptotic process (GO:0033033)3.09633714
122T cell homeostasis (GO:0043029)3.08704981
123negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.07623007
124type I interferon signaling pathway (GO:0060337)3.07523593
125cellular response to type I interferon (GO:0071357)3.07523593
126positive regulation of immunoglobulin production (GO:0002639)3.06811412
127regulation of interferon-alpha production (GO:0032647)3.06055917
128regulation of respiratory burst (GO:0060263)3.05826818
129positive regulation of interferon-gamma production (GO:0032729)3.04228415
130immune response-activating cell surface receptor signaling pathway (GO:0002429)3.03497563
131Peyers patch development (GO:0048541)3.03286494
132detection of other organism (GO:0098543)3.00887021
133neutrophil activation involved in immune response (GO:0002283)2.97288286
134negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.94797010

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.08381254
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.67489568
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.24622890
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.15487526
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.08599643
6STAT4_19710469_ChIP-ChIP_TH1__Mouse4.07324479
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.89979758
8RUNX_20019798_ChIP-Seq_JUKART_Human3.75494084
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.68239943
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.41747729
11* MYB_26560356_Chip-Seq_TH2_Human3.16861827
12* MAF_26560356_Chip-Seq_TH1_Human3.12049648
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.06037191
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.01487667
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.86710811
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.83813062
17* MYB_26560356_Chip-Seq_TH1_Human2.72704084
18* UTX_26944678_Chip-Seq_JUKART_Human2.69769565
19MYC_22102868_ChIP-Seq_BL_Human2.62810500
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.44738225
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.41625425
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34613762
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27639598
24RUNX1_22412390_ChIP-Seq_EML_Mouse2.26105850
25BP1_19119308_ChIP-ChIP_Hs578T_Human2.24411092
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.19339029
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10779662
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.09084448
29MAF_26560356_Chip-Seq_TH2_Human2.04294691
30SCL_19346495_ChIP-Seq_HPC-7_Human2.01894556
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.99977650
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98762841
33* GATA3_27048872_Chip-Seq_THYMUS_Human1.98280983
34SPI1_23547873_ChIP-Seq_NB4_Human1.98148280
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94907565
36VDR_21846776_ChIP-Seq_THP-1_Human1.92765991
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89887613
38* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.81621978
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81509704
40SPI1_23127762_ChIP-Seq_K562_Human1.72111151
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71631246
42ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.67504702
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.62135468
44VDR_24763502_ChIP-Seq_THP-1_Human1.61280032
45* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60508212
46TCF7_22412390_ChIP-Seq_EML_Mouse1.53314790
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.51115486
48RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.48315749
49CIITA_25753668_ChIP-Seq_RAJI_Human1.41059072
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40722297
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40628187
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37351138
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36961359
54VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.36593077
55KDM2B_26808549_Chip-Seq_DND41_Human1.33586798
56PPARA_22158963_ChIP-Seq_LIVER_Mouse1.33117426
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31756896
58PU_27001747_Chip-Seq_BMDM_Mouse1.28345164
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28022811
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27586260
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26007101
62GATA3_26560356_Chip-Seq_TH2_Human1.25308372
63BCOR_27268052_Chip-Seq_Bcells_Human1.25142153
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24885670
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23505953
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22521585
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22462575
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.21721357
69RXR_22158963_ChIP-Seq_LIVER_Mouse1.20852807
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20056611
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19642499
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17509926
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16790972
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16738671
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16648709
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13486274
77* P300_27268052_Chip-Seq_Bcells_Human1.13374048
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12783521
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.12482714
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11320262
81LXR_22292898_ChIP-Seq_THP-1_Human1.10530085
82RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.08636316
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.06718842
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05573877
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04193686
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.03832191
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97419307
88VDR_23849224_ChIP-Seq_CD4+_Human0.97399299
89GATA1_19941827_ChIP-Seq_MEL_Mouse0.94495234
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93463734
91CTCF_26484167_Chip-Seq_Bcells_Mouse0.92326080
92TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91626105
93EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91558270
94IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90716778
95PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90260192
96GATA3_26560356_Chip-Seq_TH1_Human0.90052641
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89745292
98GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88883728
99ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88843033
100PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88126680
101STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87209873
102KDM2B_26808549_Chip-Seq_JURKAT_Human0.86018696
103PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85302679
104PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84455962
105GATA1_22025678_ChIP-Seq_K562_Human0.83870087
106VDR_24787735_ChIP-Seq_THP-1_Human0.83764143
107GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83553990
108SA1_27219007_Chip-Seq_Bcells_Human0.83083314
109BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82241874
110* P68_20966046_ChIP-Seq_HELA_Human0.81671384
111E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.80966452
112SA1_27219007_Chip-Seq_ERYTHROID_Human0.80867928
113RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80553509
114EGR1_19032775_ChIP-ChIP_M12_Human0.78029087
115RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76694631
116BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.74702314
117CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74125683
118GATA2_19941826_ChIP-Seq_K562_Human0.72008773
119FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71266105
120BCL6_27268052_Chip-Seq_Bcells_Human0.70491237
121HOXB4_20404135_ChIP-ChIP_EML_Mouse0.69437835
122SPI1_20517297_ChIP-Seq_HL60_Human0.68793260
123GATA1_19941826_ChIP-Seq_K562_Human0.68775774

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.10483109
2MP0003763_abnormal_thymus_physiology4.05987644
3MP0006082_CNS_inflammation3.89761476
4MP0001835_abnormal_antigen_presentation3.73022367
5MP0009785_altered_susceptibility_to3.62806653
6MP0003724_increased_susceptibility_to3.25758104
7MP0001800_abnormal_humoral_immune3.24902953
8MP0000685_abnormal_immune_system3.10509237
9MP0005000_abnormal_immune_tolerance3.03856561
10MP0005025_abnormal_response_to2.97067016
11MP0005387_immune_system_phenotype2.94361586
12MP0001790_abnormal_immune_system2.94361586
13MP0002420_abnormal_adaptive_immunity2.87717167
14MP0002723_abnormal_immune_serum2.86344056
15MP0001819_abnormal_immune_cell2.85494209
16MP0002166_altered_tumor_susceptibility2.78660071
17MP0002452_abnormal_antigen_presenting2.59449860
18MP0002398_abnormal_bone_marrow2.49269985
19MP0004947_skin_inflammation2.48931059
20MP0002933_joint_inflammation2.39456569
21MP0002405_respiratory_system_inflammati2.37074980
22MP0000716_abnormal_immune_system2.33567855
23MP0003300_gastrointestinal_ulcer2.28085759
24MP0002419_abnormal_innate_immunity2.27727541
25MP0002006_tumorigenesis2.19922621
26MP0010155_abnormal_intestine_physiology2.19390862
27MP0001873_stomach_inflammation2.17486483
28MP0002722_abnormal_immune_system2.16170629
29MP0009333_abnormal_splenocyte_physiolog2.11551013
30MP0000703_abnormal_thymus_morphology2.08960164
31MP0003436_decreased_susceptibility_to2.04976170
32MP0005464_abnormal_platelet_physiology2.00897877
33MP0000689_abnormal_spleen_morphology1.96691996
34MP0002429_abnormal_blood_cell1.86260144
35MP0001845_abnormal_inflammatory_respons1.85486682
36MP0001986_abnormal_taste_sensitivity1.82716736
37MP0000858_altered_metastatic_potential1.80773273
38MP0002148_abnormal_hypersensitivity_rea1.71992270
39MP0003303_peritoneal_inflammation1.66517193
40MP0003448_altered_tumor_morphology1.64950221
41MP0008469_abnormal_protein_level1.53943461
42MP0001851_eye_inflammation1.53788938
43MP0004510_myositis1.52179955
44MP0003866_abnormal_defecation1.48867723
45MP0001533_abnormal_skeleton_physiology1.43619557
46MP0005310_abnormal_salivary_gland1.42690821
47MP0001853_heart_inflammation1.36617607
48MP0002998_abnormal_bone_remodeling1.31292708
49MP0002396_abnormal_hematopoietic_system1.26032088
50MP0003045_fibrosis1.21762326
51MP0000343_altered_response_to1.16933012
52MP0009763_increased_sensitivity_to1.16647456
53MP0009840_abnormal_foam_cell1.14341943
54MP0002277_abnormal_respiratory_mucosa1.12150288
55MP0002653_abnormal_ependyma_morphology1.10435654
56MP0000465_gastrointestinal_hemorrhage1.05896217
57MP0001348_abnormal_lacrimal_gland1.03517393
58MP0005360_urolithiasis1.03319032
59MP0005023_abnormal_wound_healing1.01358614
60MP0010234_abnormal_vibrissa_follicle0.98940293
61MP0003172_abnormal_lysosome_physiology0.94976155
62MP0002163_abnormal_gland_morphology0.91075299
63MP0000490_abnormal_crypts_of0.90293398
64MP0000604_amyloidosis0.89040488
65MP0000609_abnormal_liver_physiology0.88972820
66MP0002693_abnormal_pancreas_physiology0.88579572
67MP0005058_abnormal_lysosome_morphology0.87262873
68MP0004130_abnormal_muscle_cell0.87154551
69MP0002019_abnormal_tumor_incidence0.85505810
70MP0005083_abnormal_biliary_tract0.84587717
71MP0003183_abnormal_peptide_metabolism0.81681379
72MP0004381_abnormal_hair_follicle0.75217818
73MP0002132_abnormal_respiratory_system0.74820651
74MP0004808_abnormal_hematopoietic_stem0.73572772
75MP0006054_spinal_hemorrhage0.72744034
76MP0003191_abnormal_cellular_cholesterol0.70313191
77MP0009764_decreased_sensitivity_to0.70233416
78MP0000249_abnormal_blood_vessel0.67882438
79MP0005166_decreased_susceptibility_to0.66540677
80MP0005076_abnormal_cell_differentiation0.64955275
81MP0005075_abnormal_melanosome_morpholog0.64486327
82MP0003795_abnormal_bone_structure0.64413647
83MP0003075_altered_response_to0.64029791
84MP0005085_abnormal_gallbladder_physiolo0.63514527
85MP0005365_abnormal_bile_salt0.62372535
86MP0009765_abnormal_xenobiotic_induced0.61890229
87MP0001919_abnormal_reproductive_system0.61712688
88MP0002136_abnormal_kidney_physiology0.59820031
89MP0000477_abnormal_intestine_morphology0.59534265
90MP0010329_abnormal_lipoprotein_level0.58739712
91MP0003806_abnormal_nucleotide_metabolis0.56619546
92MP0003646_muscle_fatigue0.56338658
93MP0001191_abnormal_skin_condition0.56141220
94MP0001881_abnormal_mammary_gland0.55904525
95MP0002009_preneoplasia0.55457334
96MP0005390_skeleton_phenotype0.55261360
97MP0005584_abnormal_enzyme/coenzyme_acti0.54572701
98MP0003566_abnormal_cell_adhesion0.53569172
99MP0002139_abnormal_hepatobiliary_system0.53465169
100MP0000598_abnormal_liver_morphology0.52484544
101MP0004145_abnormal_muscle_electrophysio0.52382633
102MP0003252_abnormal_bile_duct0.51985199
103MP0002138_abnormal_hepatobiliary_system0.51554866
104MP0008873_increased_physiological_sensi0.50562878
105MP0001501_abnormal_sleep_pattern0.50143441
106MP0000920_abnormal_myelination0.49718980
107MP0009643_abnormal_urine_homeostasis0.49215806
108MP0003453_abnormal_keratinocyte_physiol0.48796545
109MP0008875_abnormal_xenobiotic_pharmacok0.48520449
110MP0008872_abnormal_physiological_respon0.47566408
111MP0009278_abnormal_bone_marrow0.47556404
112MP0001663_abnormal_digestive_system0.45504626
113MP0003329_amyloid_beta_deposits0.45193592
114MP0010307_abnormal_tumor_latency0.44355683
115MP0005174_abnormal_tail_pigmentation0.43879865
116MP0001765_abnormal_ion_homeostasis0.42498062
117MP0008961_abnormal_basal_metabolism0.42448281
118MP0005645_abnormal_hypothalamus_physiol0.42154192
119MP0003279_aneurysm0.41146131
120MP0001764_abnormal_homeostasis0.40411196
121MP0002254_reproductive_system_inflammat0.37640942
122MP0009642_abnormal_blood_homeostasis0.37513937
123MP0008877_abnormal_DNA_methylation0.37443662
124MP0004883_abnormal_blood_vessel0.36843404
125MP0005381_digestive/alimentary_phenotyp0.34024740
126MP0002083_premature_death0.33505144
127MP0008874_decreased_physiological_sensi0.33113666

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)6.19116956
2Optic neuritis (HP:0100653)6.19116956
3Myositis (HP:0100614)6.14403342
4Severe combined immunodeficiency (HP:0004430)6.11194939
5Orchitis (HP:0100796)5.87678020
6Combined immunodeficiency (HP:0005387)5.45995324
7T lymphocytopenia (HP:0005403)5.40878638
8Abnormality of T cell number (HP:0011839)5.30036786
9Eczematoid dermatitis (HP:0000976)4.73517869
10Elevated erythrocyte sedimentation rate (HP:0003565)4.69891005
11Chronic mucocutaneous candidiasis (HP:0002728)4.48459255
12Recurrent cutaneous fungal infections (HP:0011370)4.48459255
13Recurrent bronchitis (HP:0002837)4.45095866
14Thyroiditis (HP:0100646)4.38121836
15Autoimmune hemolytic anemia (HP:0001890)4.30041410
16Recurrent abscess formation (HP:0002722)4.23588937
17Keratoconjunctivitis sicca (HP:0001097)4.19435053
18IgM deficiency (HP:0002850)4.13230567
19Recurrent fungal infections (HP:0002841)4.07286541
20Stomatitis (HP:0010280)3.97132324
21Abnormality of T cells (HP:0002843)3.94435352
22Keratoconjunctivitis (HP:0001096)3.77572751
23Lymphopenia (HP:0001888)3.73484301
24Pulmonary infiltrates (HP:0002113)3.72588268
25IgG deficiency (HP:0004315)3.70739822
26Hypoplasia of the thymus (HP:0000778)3.65891185
27Chronic diarrhea (HP:0002028)3.62943520
28Abnormality of cells of the lymphoid lineage (HP:0012140)3.61563695
29Hemoptysis (HP:0002105)3.61274753
30Meningitis (HP:0001287)3.60140687
31Obstructive lung disease (HP:0006536)3.53205914
32Chronic obstructive pulmonary disease (HP:0006510)3.53205914
33Granulocytopenia (HP:0001913)3.51223309
34Abnormality of eosinophils (HP:0001879)3.48451147
35Nasal polyposis (HP:0100582)3.47383310
36Pulmonary embolism (HP:0002204)3.40567169
37Vasculitis (HP:0002633)3.38601507
38Gangrene (HP:0100758)3.36249476
39Arterial thrombosis (HP:0004420)3.36062203
40Leukocytosis (HP:0001974)3.32157885
41Joint swelling (HP:0001386)3.31594903
42Recurrent skin infections (HP:0001581)3.29135111
43Encephalitis (HP:0002383)3.23414060
44Increased IgE level (HP:0003212)3.20275091
45Recurrent gram-negative bacterial infections (HP:0005420)3.14367576
46Panhypogammaglobulinemia (HP:0003139)2.97643005
47Agammaglobulinemia (HP:0004432)2.95427756
48Abnormality of the prostate (HP:0008775)2.88838632
49Aplastic anemia (HP:0001915)2.88007893
50Abnormality of the nasal mucosa (HP:0000433)2.87345474
51Gingivitis (HP:0000230)2.75539433
52Recurrent bacterial skin infections (HP:0005406)2.75313508
53Verrucae (HP:0200043)2.75288773
54Papilloma (HP:0012740)2.75288773
55Mediastinal lymphadenopathy (HP:0100721)2.73416366
56Hypochromic anemia (HP:0001931)2.72341308
57Recurrent viral infections (HP:0004429)2.71245572
58Recurrent sinusitis (HP:0011108)2.69730675
59Gastrointestinal stroma tumor (HP:0100723)2.69614091
60Increased IgM level (HP:0003496)2.69244698
61Abnormality of T cell physiology (HP:0011840)2.63387384
62Autoimmune thrombocytopenia (HP:0001973)2.63047436
63Anorexia (HP:0002039)2.61085239
64Abnormality of B cell number (HP:0010975)2.57064865
65B lymphocytopenia (HP:0010976)2.57064865
66Sepsis (HP:0100806)2.56397582
67Ureteral stenosis (HP:0000071)2.51015286
68Abnormality of the pleura (HP:0002103)2.50601435
69Systemic lupus erythematosus (HP:0002725)2.47593966
70Chronic otitis media (HP:0000389)2.47378183
71Gastrointestinal infarctions (HP:0005244)2.45581615
72Polyneuropathy (HP:0001271)2.40412036
73Abnormal delayed hypersensitivity skin test (HP:0002963)2.39407444
74Inflammation of the large intestine (HP:0002037)2.39375744
75Cellulitis (HP:0100658)2.39160254
76Glomerulopathy (HP:0100820)2.35995819
77Thrombophlebitis (HP:0004418)2.33718633
78Abnormality of the pericardium (HP:0001697)2.33612302
79Bronchitis (HP:0012387)2.33167762
80Abnormality of macrophages (HP:0004311)2.30932927
81Ureteral obstruction (HP:0006000)2.30763367
82Hypochromic microcytic anemia (HP:0004840)2.29401657
83Keratitis (HP:0000491)2.29181776
84Chronic sinusitis (HP:0011109)2.27524719
85Recurrent otitis media (HP:0000403)2.26192360
86Pustule (HP:0200039)2.26036429
87Gastrointestinal inflammation (HP:0004386)2.23150895
88Prolonged bleeding time (HP:0003010)2.22994843
89Petechiae (HP:0000967)2.21547159
90Hemiplegia (HP:0002301)2.20209650
91Epistaxis (HP:0000421)2.17541987
92Hypergammaglobulinemia (HP:0010702)2.14075991
93Eosinophilia (HP:0001880)2.13031109
94Stomach cancer (HP:0012126)2.12243890
95Colitis (HP:0002583)2.11467838
96Increased neuronal autofluorescent lipopigment (HP:0002074)2.09615080
97Hypoproteinemia (HP:0003075)2.08124102
98Chest pain (HP:0100749)2.06641334
99Increased cerebral lipofuscin (HP:0011813)2.02887852
100Abnormality of the endocardium (HP:0004306)2.02742331
101IgA deficiency (HP:0002720)1.99864451
102Gingival bleeding (HP:0000225)1.99037561
103Osteomyelitis (HP:0002754)1.98675447
104Recurrent pneumonia (HP:0006532)1.97614349
105Periodontitis (HP:0000704)1.96507939
106Spontaneous hematomas (HP:0007420)1.95072864
107Arthralgia (HP:0002829)1.93863973
108Skin rash (HP:0000988)1.92554493
109Abnormality of the common coagulation pathway (HP:0010990)1.91790651
110Purpura (HP:0000979)1.91041126
111Entropion (HP:0000621)1.90501569
112Microcytic anemia (HP:0001935)1.88500661
113Increased serum ferritin (HP:0003281)1.86651776
114Urticaria (HP:0001025)1.83722391
115Lymphoma (HP:0002665)1.83622583
116Acute hepatic failure (HP:0006554)1.81674381
117Recurrent lower respiratory tract infections (HP:0002783)1.81082828
118Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.80159421
119Abnormal albumin level (HP:0012116)1.78670046
120Hypoalbuminemia (HP:0003073)1.78670046

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK8.15923763
2MAP4K14.22989903
3KDR3.53408816
4IKBKE3.26706928
5FGFR43.21653909
6PASK3.15470614
7JAK13.08211266
8RIPK42.99019314
9ZAP702.91223540
10TYK22.90505184
11ITK2.81139106
12TBK12.68748516
13TESK22.19562529
14JAK32.18540540
15CAMKK12.03059735
16LCK2.01680456
17KIT1.92863310
18BLK1.74626104
19FGFR31.71131113
20CAMKK21.62704210
21MAP3K121.61142055
22TEC1.48100015
23MAP3K141.47555719
24HCK1.45221023
25STK101.44317032
26SYK1.43258788
27GRK61.42236348
28CSK1.39292410
29TAOK31.39082998
30ERN11.37223460
31BTK1.32117631
32PRKCH1.21101260
33PRPF4B1.12443119
34MAP2K61.11837844
35NEK91.10198591
36TAOK11.06088463
37FES1.05317893
38IKBKB1.02813339
39LYN0.99883541
40JAK20.92883251
41IRAK40.92833090
42PRKCQ0.92348909
43TLK10.92055563
44BMPR20.91782483
45TESK10.87000140
46IRAK30.85087817
47MAP3K130.84626094
48TGFBR20.82521931
49MAPK110.81583955
50CSF1R0.80584076
51FGFR10.79691089
52FYN0.79403761
53EPHB10.77742673
54GRK70.75193328
55DMPK0.72855317
56IGF1R0.70768686
57SIK20.70671549
58LRRK20.68618082
59TRIB30.68184753
60DAPK20.67826397
61TNK20.66876024
62SIK10.66364788
63NME20.64581549
64PKN20.63273927
65PIK3CG0.59442422
66INSR0.57593216
67TYRO30.56258932
68MAP2K20.52661290
69MAP3K110.52339996
70MAPKAPK30.49231729
71STK240.48719573
72CDK190.48205652
73CDK90.47577814
74MAPK70.45901183
75MAP3K100.45668491
76MAP3K30.43463981
77MST40.40863116
78ADRBK20.40811489
79STK380.40300190
80ZAK0.40182237
81HIPK20.39530146
82SCYL20.39268284
83MYLK0.39150290
84VRK10.38782127
85DAPK30.37804882
86MAPKAPK20.37739970
87PAK40.37400147
88RPS6KA50.36738636
89PDK10.36667166
90SMG10.36171764
91CLK10.36025095
92LIMK10.35854039
93PRKCD0.35694179
94PIM10.34124114
95MAPK120.33398790
96CHUK0.32846800
97MAP2K30.32790984
98EEF2K0.32483821
99GRK10.32134945
100TAOK20.29861231
101CDK40.29718552
102STK110.29027281
103PDGFRB0.29015646
104MAP4K20.25965492
105MAP3K70.24784553
106NLK0.24680417
107PDPK10.24539766
108ILK0.24310953
109TTN0.24285650
110PRKD20.24204244
111SRC0.23940665
112GSK3A0.23921906
113PTK60.22836256
114MAPK40.22606114
115ABL10.22415269
116EPHA30.21900192
117RPS6KA40.21450667
118MAPK30.21398216
119MARK30.21348399
120CDK60.20813253
121MAPK150.20500538
122ALK0.20398846
123SIK30.20264347
124ACVR1B0.19876440
125MAP3K50.19790457
126EGFR0.19531747
127MARK20.19157901
128FGR0.18688518
129DAPK10.17182116
130MAP3K10.16201479
131YES10.15343904
132PRKCZ0.12447564

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.76550455
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.12665555
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053214.07958024
4Graft-versus-host disease_Homo sapiens_hsa053323.57680363
5T cell receptor signaling pathway_Homo sapiens_hsa046603.49783541
6Antigen processing and presentation_Homo sapiens_hsa046123.26060518
7Hematopoietic cell lineage_Homo sapiens_hsa046402.98859532
8Measles_Homo sapiens_hsa051622.88236928
9Allograft rejection_Homo sapiens_hsa053302.84237259
10Staphylococcus aureus infection_Homo sapiens_hsa051502.76661137
11Autoimmune thyroid disease_Homo sapiens_hsa053202.53292960
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.52707546
13Leishmaniasis_Homo sapiens_hsa051402.33555447
14NF-kappa B signaling pathway_Homo sapiens_hsa040642.08306499
15Asthma_Homo sapiens_hsa053101.94590396
16Osteoclast differentiation_Homo sapiens_hsa043801.89338392
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.84733232
18Viral myocarditis_Homo sapiens_hsa054161.82888591
19Other glycan degradation_Homo sapiens_hsa005111.64678715
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62146342
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.57341057
22B cell receptor signaling pathway_Homo sapiens_hsa046621.55743311
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49968069
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.47524473
25Malaria_Homo sapiens_hsa051441.46252424
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38637919
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.36629081
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.32705619
29Chemokine signaling pathway_Homo sapiens_hsa040621.30607962
30Apoptosis_Homo sapiens_hsa042101.15074445
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13656817
32Shigellosis_Homo sapiens_hsa051311.11496743
33Toxoplasmosis_Homo sapiens_hsa051451.09679058
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07403666
35Caffeine metabolism_Homo sapiens_hsa002321.02976683
36Systemic lupus erythematosus_Homo sapiens_hsa053221.01258006
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01187672
38Lysosome_Homo sapiens_hsa041420.96693064
39Herpes simplex infection_Homo sapiens_hsa051680.94568922
40Complement and coagulation cascades_Homo sapiens_hsa046100.92186435
41Glycosaminoglycan degradation_Homo sapiens_hsa005310.90574447
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88045075
43Hepatitis B_Homo sapiens_hsa051610.86033853
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85066135
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77814399
46Pancreatic cancer_Homo sapiens_hsa052120.75862212
47TNF signaling pathway_Homo sapiens_hsa046680.75139204
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.74458729
49Tuberculosis_Homo sapiens_hsa051520.73846280
50Pertussis_Homo sapiens_hsa051330.73357464
51HTLV-I infection_Homo sapiens_hsa051660.72511050
52VEGF signaling pathway_Homo sapiens_hsa043700.72460918
53Legionellosis_Homo sapiens_hsa051340.71070498
54Influenza A_Homo sapiens_hsa051640.70179307
55Regulation of autophagy_Homo sapiens_hsa041400.68052971
56Platelet activation_Homo sapiens_hsa046110.65634709
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55507506
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54151457
59Non-small cell lung cancer_Homo sapiens_hsa052230.52380363
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52224793
61Salmonella infection_Homo sapiens_hsa051320.50899124
62Sulfur relay system_Homo sapiens_hsa041220.50728981
63Epstein-Barr virus infection_Homo sapiens_hsa051690.50058603
64Type I diabetes mellitus_Homo sapiens_hsa049400.47612962
65Endocytosis_Homo sapiens_hsa041440.45979309
66Viral carcinogenesis_Homo sapiens_hsa052030.45700167
67Rheumatoid arthritis_Homo sapiens_hsa053230.45096506
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44649342
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37736451
70Hepatitis C_Homo sapiens_hsa051600.36168685
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35954827
72Alcoholism_Homo sapiens_hsa050340.35590976
73p53 signaling pathway_Homo sapiens_hsa041150.34870180
74MAPK signaling pathway_Homo sapiens_hsa040100.31961058
75Pentose phosphate pathway_Homo sapiens_hsa000300.30892395
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30607767
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.28744437
78Phototransduction_Homo sapiens_hsa047440.27967912
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25931539
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25329058
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.24550932
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24436252
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24047681
84FoxO signaling pathway_Homo sapiens_hsa040680.23284628
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22184674
86Insulin resistance_Homo sapiens_hsa049310.22069597
87Rap1 signaling pathway_Homo sapiens_hsa040150.21042349
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.20433162
89Nitrogen metabolism_Homo sapiens_hsa009100.20227213
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19993488
91African trypanosomiasis_Homo sapiens_hsa051430.19679668
92Colorectal cancer_Homo sapiens_hsa052100.19319040
93Nucleotide excision repair_Homo sapiens_hsa034200.19311656
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.19047297
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.17844626
96Acute myeloid leukemia_Homo sapiens_hsa052210.17096862
97Prolactin signaling pathway_Homo sapiens_hsa049170.16435821
98Choline metabolism in cancer_Homo sapiens_hsa052310.16267687
99ABC transporters_Homo sapiens_hsa020100.14875892
100Ras signaling pathway_Homo sapiens_hsa040140.14680595
101Proteasome_Homo sapiens_hsa030500.14589072
102Linoleic acid metabolism_Homo sapiens_hsa005910.13077787
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13055612
104Notch signaling pathway_Homo sapiens_hsa043300.13044538
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.12580394
106Fatty acid degradation_Homo sapiens_hsa000710.12227845
107Glycerolipid metabolism_Homo sapiens_hsa005610.11380519
108Olfactory transduction_Homo sapiens_hsa047400.11346196
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.11139212
110Long-term potentiation_Homo sapiens_hsa047200.10671469
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.10275636
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.10210441
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.10056996
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.09754105
115Chronic myeloid leukemia_Homo sapiens_hsa052200.07412723
116Arginine biosynthesis_Homo sapiens_hsa002200.07364757
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07154694
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.05603124
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.05446936
120Ribosome_Homo sapiens_hsa030100.04128869
121Phagosome_Homo sapiens_hsa041450.03978451
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.03301216
123Chemical carcinogenesis_Homo sapiens_hsa052040.03047445
124Sphingolipid metabolism_Homo sapiens_hsa006000.02935095
125Tryptophan metabolism_Homo sapiens_hsa003800.02841951
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.02509183
127Amoebiasis_Homo sapiens_hsa051460.02444624

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »