PUS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the formation of tRNA pseudouridine from tRNA uridine at position 39 in the anticodon stem and loop of transfer RNAs. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.96038985
2DNA deamination (GO:0045006)5.04664739
3maturation of SSU-rRNA (GO:0030490)5.02220132
4viral transcription (GO:0019083)4.92400015
5translational termination (GO:0006415)4.86293723
6ribosomal small subunit biogenesis (GO:0042274)4.61818218
7DNA strand elongation involved in DNA replication (GO:0006271)4.51507000
8ribosomal large subunit biogenesis (GO:0042273)4.45285727
9telomere maintenance via semi-conservative replication (GO:0032201)4.44060419
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.40856840
11translational elongation (GO:0006414)4.32592666
12cotranslational protein targeting to membrane (GO:0006613)4.31145775
13chaperone-mediated protein transport (GO:0072321)4.31072888
14protein targeting to ER (GO:0045047)4.28717635
15DNA strand elongation (GO:0022616)4.27461233
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.24619360
17CENP-A containing nucleosome assembly (GO:0034080)4.11510403
18telomere maintenance via recombination (GO:0000722)4.09527736
19establishment of protein localization to endoplasmic reticulum (GO:0072599)4.09192955
20DNA replication initiation (GO:0006270)4.08677027
21protein localization to endoplasmic reticulum (GO:0070972)4.08621091
22respiratory chain complex IV assembly (GO:0008535)4.08077381
23protein complex biogenesis (GO:0070271)4.07432853
24DNA replication checkpoint (GO:0000076)4.06917714
25translational initiation (GO:0006413)4.03933434
26ribonucleoprotein complex biogenesis (GO:0022613)3.98805403
27mitochondrial respiratory chain complex assembly (GO:0033108)3.98789478
28DNA double-strand break processing (GO:0000729)3.98136034
29chromatin remodeling at centromere (GO:0031055)3.96181820
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.95038609
31transcription elongation from RNA polymerase III promoter (GO:0006385)3.94881346
32termination of RNA polymerase III transcription (GO:0006386)3.94881346
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.93011378
34DNA unwinding involved in DNA replication (GO:0006268)3.91679650
35establishment of integrated proviral latency (GO:0075713)3.88018885
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.81899936
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.81899936
38ATP synthesis coupled proton transport (GO:0015986)3.80643603
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.80643603
40mitotic recombination (GO:0006312)3.80129413
41cellular protein complex disassembly (GO:0043624)3.78895220
42formation of translation preinitiation complex (GO:0001731)3.73921160
43viral life cycle (GO:0019058)3.71860509
44regulation of mitochondrial translation (GO:0070129)3.71150293
45cytochrome complex assembly (GO:0017004)3.70104907
46water-soluble vitamin biosynthetic process (GO:0042364)3.64919134
47nucleobase biosynthetic process (GO:0046112)3.64676023
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.61592156
49DNA replication-independent nucleosome organization (GO:0034724)3.60491057
50DNA replication-independent nucleosome assembly (GO:0006336)3.60491057
51maturation of 5.8S rRNA (GO:0000460)3.59176896
52ribosome biogenesis (GO:0042254)3.58811223
53deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.58792245
54mitochondrial respiratory chain complex I assembly (GO:0032981)3.57568584
55NADH dehydrogenase complex assembly (GO:0010257)3.57568584
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57568584
57proteasome assembly (GO:0043248)3.54542326
58purine nucleobase biosynthetic process (GO:0009113)3.54133891
59rRNA processing (GO:0006364)3.53884733
60spliceosomal snRNP assembly (GO:0000387)3.50671109
61nucleotide-excision repair, DNA gap filling (GO:0006297)3.46592111
62telomere maintenance via telomere lengthening (GO:0010833)3.45391736
63rRNA metabolic process (GO:0016072)3.43745138
64protein-cofactor linkage (GO:0018065)3.41795560
65mitochondrial RNA metabolic process (GO:0000959)3.40052926
66protein complex disassembly (GO:0043241)3.37197852
67translation (GO:0006412)3.34003275
68* pseudouridine synthesis (GO:0001522)3.33086631
69IMP biosynthetic process (GO:0006188)3.32929758
70regulation of cellular amino acid metabolic process (GO:0006521)3.29978346
71cellular component biogenesis (GO:0044085)3.28466750
72DNA catabolic process, exonucleolytic (GO:0000738)3.28302697
73histone exchange (GO:0043486)3.27913337
74negative regulation of DNA-dependent DNA replication (GO:2000104)3.27657857
75synapsis (GO:0007129)3.25987499
76nuclear-transcribed mRNA catabolic process (GO:0000956)3.24885304
77exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.23625371
78macromolecular complex disassembly (GO:0032984)3.21370658
79negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.20417447
80rRNA methylation (GO:0031167)3.20157770
81peptidyl-histidine modification (GO:0018202)3.19691094
82nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.18726160
83DNA replication-dependent nucleosome assembly (GO:0006335)3.18049630
84DNA replication-dependent nucleosome organization (GO:0034723)3.18049630
85establishment of viral latency (GO:0019043)3.18045852
86L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.16342304
87protein localization to kinetochore (GO:0034501)3.16149212
88rRNA modification (GO:0000154)3.14373279
89respiratory electron transport chain (GO:0022904)3.12857771
90transcription-coupled nucleotide-excision repair (GO:0006283)3.08928023
91* tRNA processing (GO:0008033)3.08815821
92electron transport chain (GO:0022900)3.08539526
93mRNA catabolic process (GO:0006402)3.08326604
94folic acid-containing compound biosynthetic process (GO:0009396)3.08186539
95double-strand break repair via nonhomologous end joining (GO:0006303)3.07743754
96non-recombinational repair (GO:0000726)3.07743754
97pteridine-containing compound biosynthetic process (GO:0042559)3.06978547
98transcription from mitochondrial promoter (GO:0006390)3.05870374
99L-serine metabolic process (GO:0006563)3.05014280
100regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.03821428
101signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.03690544
102protein targeting to mitochondrion (GO:0006626)3.02506082
103DNA damage response, detection of DNA damage (GO:0042769)3.02312976
104termination of RNA polymerase I transcription (GO:0006363)3.02225679
105RNA catabolic process (GO:0006401)3.01660029
106somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.01017460
107isotype switching (GO:0045190)3.01017460
108somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.01017460
109positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.00526250
110protein neddylation (GO:0045116)3.00011775
111mitotic metaphase plate congression (GO:0007080)2.99339061
112spliceosomal complex assembly (GO:0000245)2.99234101
113ribosome assembly (GO:0042255)2.98826006
114negative regulation of ligase activity (GO:0051352)2.98646555
115negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.98646555
116positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.98518519
117regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.98456029
118anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.98416246
1197-methylguanosine mRNA capping (GO:0006370)2.97196144
1207-methylguanosine RNA capping (GO:0009452)2.97131833
121RNA capping (GO:0036260)2.97131833
122protein localization to mitochondrion (GO:0070585)2.96656715
123transcription elongation from RNA polymerase I promoter (GO:0006362)2.94755231
124IMP metabolic process (GO:0046040)2.91735099
125cullin deneddylation (GO:0010388)2.91433366
126signal transduction involved in DNA integrity checkpoint (GO:0072401)2.91051812
127signal transduction involved in DNA damage checkpoint (GO:0072422)2.91051812
128signal transduction involved in cell cycle checkpoint (GO:0072395)2.90334080
129positive regulation of ligase activity (GO:0051351)2.89608416
130replication fork processing (GO:0031297)2.87336131
131telomere maintenance (GO:0000723)2.87306079
132viral mRNA export from host cell nucleus (GO:0046784)2.86667395
133telomere organization (GO:0032200)2.86009790
134* tRNA metabolic process (GO:0006399)2.85466011
135protein deneddylation (GO:0000338)2.84367133
136establishment of protein localization to mitochondrion (GO:0072655)2.83508420
137transcription from RNA polymerase I promoter (GO:0006360)2.83295740
138regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.81228890
139regulation of mitotic spindle checkpoint (GO:1903504)2.81228890
140DNA-templated transcription, termination (GO:0006353)2.81207189
141DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.80748226
142kinetochore organization (GO:0051383)2.80305398
143RNA splicing, via transesterification reactions (GO:0000375)2.79875261
144signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.79698609
145intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.79698609
146RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.79589007
147mRNA splicing, via spliceosome (GO:0000398)2.79589007
148cellular ketone body metabolic process (GO:0046950)2.79490758
149branched-chain amino acid catabolic process (GO:0009083)2.78569354
150kinetochore assembly (GO:0051382)2.78534784
151* ncRNA processing (GO:0034470)2.78091740
152signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.77336479
153signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.77336479
154histone mRNA metabolic process (GO:0008334)2.71617365
155regulation of ubiquitin-protein transferase activity (GO:0051438)2.68858143
156homocysteine metabolic process (GO:0050667)2.67248812

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.17354889
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.39945544
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.88993080
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.75701466
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.52357927
6* EST1_17652178_ChIP-ChIP_JURKAT_Human3.47323637
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.35575295
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.13493225
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.12000726
10ELF1_17652178_ChIP-ChIP_JURKAT_Human3.03686209
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86546866
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.86476188
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84641620
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81337283
15* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76012614
16VDR_23849224_ChIP-Seq_CD4+_Human2.68790026
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61403922
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.52918296
19* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.51941633
20XRN2_22483619_ChIP-Seq_HELA_Human2.47716154
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.43370947
22FOXP3_21729870_ChIP-Seq_TREG_Human2.40927449
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37477421
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36599339
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.35585822
26ELK1_19687146_ChIP-ChIP_HELA_Human2.27145998
27ZNF274_21170338_ChIP-Seq_K562_Hela2.26975062
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.25952370
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.15793684
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13476709
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05784825
32GABP_19822575_ChIP-Seq_HepG2_Human2.05367348
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.03740642
34EWS_26573619_Chip-Seq_HEK293_Human2.03319733
35DCP1A_22483619_ChIP-Seq_HELA_Human2.00957106
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.97852414
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97579463
38TTF2_22483619_ChIP-Seq_HELA_Human1.96811156
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.94149330
40AR_21909140_ChIP-Seq_LNCAP_Human1.94119392
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.93915665
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85176043
43VDR_22108803_ChIP-Seq_LS180_Human1.83077966
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.82191541
45* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.80079260
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79171694
47* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76825256
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.76289839
49* NOTCH1_21737748_ChIP-Seq_TLL_Human1.73529402
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.72772047
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.69930749
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69661971
53* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65634815
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64552170
55* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64382001
56FUS_26573619_Chip-Seq_HEK293_Human1.63946964
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.63574006
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61303457
59CIITA_25753668_ChIP-Seq_RAJI_Human1.54384515
60IGF1R_20145208_ChIP-Seq_DFB_Human1.53358147
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52983554
62* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52935571
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51839412
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49613732
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48046695
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.44963470
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43726501
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41197239
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39735629
70* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36533326
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34837984
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34698193
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33793563
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29027994
75P300_19829295_ChIP-Seq_ESCs_Human1.27038708
76TAF15_26573619_Chip-Seq_HEK293_Human1.26702323
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25374562
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.24279978
79KDM5A_27292631_Chip-Seq_BREAST_Human1.24077639
80SPI1_23547873_ChIP-Seq_NB4_Human1.23512826
81MYC_18940864_ChIP-ChIP_HL60_Human1.22922797
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22134940
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20028833
84* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17627866
85* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16864819
86MYC_22102868_ChIP-Seq_BL_Human1.15904894
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15555264
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15469170
89NANOG_16153702_ChIP-ChIP_HESCs_Human1.15216217
90SOX2_16153702_ChIP-ChIP_HESCs_Human1.14031815
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12579711
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11609886
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10829634
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09720131
95ELK1_22589737_ChIP-Seq_MCF10A_Human1.07824034
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06704599
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06427456
98TP53_22573176_ChIP-Seq_HFKS_Human1.04963760
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01713481
100TFEB_21752829_ChIP-Seq_HELA_Human0.99198686
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99017266
102MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98425503
103CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96870699
104SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96512336
105CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96493478
106SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96325615
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95764331
108NFE2_27457419_Chip-Seq_LIVER_Mouse0.95655251
109* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94651242
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94177251
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93623905
112CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93475438
113CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92882272
114KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92321297
115EZH2_27294783_Chip-Seq_NPCs_Mouse0.91948927
116CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91372013
117FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90902974
118EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90369896
119BP1_19119308_ChIP-ChIP_Hs578T_Human0.90337680
120PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89513620
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88781036
122TP63_19390658_ChIP-ChIP_HaCaT_Human0.88085565
123* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87519513
124EGR1_19374776_ChIP-ChIP_THP-1_Human0.86871359
125CBP_20019798_ChIP-Seq_JUKART_Human0.86509462
126IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86509462
127DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86291228
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86218587
129RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84228073
130SOX2_19829295_ChIP-Seq_ESCs_Human0.82398608
131NANOG_19829295_ChIP-Seq_ESCs_Human0.82398608
132MYB_26560356_Chip-Seq_TH2_Human0.81924894
133KLF5_20875108_ChIP-Seq_MESCs_Mouse0.81810082
134SCL_19346495_ChIP-Seq_HPC-7_Human0.81160589
135STAT4_19710469_ChIP-ChIP_TH1__Mouse0.79061541
136GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78191350
137IRF1_19129219_ChIP-ChIP_H3396_Human0.75139998
138MYB_26560356_Chip-Seq_TH1_Human0.73514234
139VDR_21846776_ChIP-Seq_THP-1_Human0.73376276

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.58040703
2MP0003693_abnormal_embryo_hatching4.23325161
3MP0010094_abnormal_chromosome_stability4.06494188
4MP0008058_abnormal_DNA_repair3.69666485
5MP0004957_abnormal_blastocyst_morpholog3.68221888
6MP0002396_abnormal_hematopoietic_system3.46484990
7MP0000569_abnormal_digit_pigmentation3.45645424
8MP0003077_abnormal_cell_cycle3.38734653
9MP0003111_abnormal_nucleus_morphology3.26439144
10MP0008007_abnormal_cellular_replicative3.20266028
11MP0006072_abnormal_retinal_apoptosis3.18768178
12MP0003763_abnormal_thymus_physiology2.53423135
13MP0003787_abnormal_imprinting2.48778029
14MP0003786_premature_aging2.48314332
15MP0008932_abnormal_embryonic_tissue2.44827499
16MP0009379_abnormal_foot_pigmentation2.23900650
17MP0004808_abnormal_hematopoietic_stem2.06188169
18MP0000490_abnormal_crypts_of1.99622407
19MP0002254_reproductive_system_inflammat1.97270116
20MP0009333_abnormal_splenocyte_physiolog1.89047566
21MP0005671_abnormal_response_to1.88000662
22MP0002837_dystrophic_cardiac_calcinosis1.86287289
23MP0005253_abnormal_eye_physiology1.76722616
24MP0003123_paternal_imprinting1.71643369
25MP0001730_embryonic_growth_arrest1.70211401
26MP0003195_calcinosis1.68609446
27MP0008877_abnormal_DNA_methylation1.68567428
28MP0000350_abnormal_cell_proliferation1.63974039
29MP0002398_abnormal_bone_marrow1.63776809
30MP0002736_abnormal_nociception_after1.61193323
31MP0005084_abnormal_gallbladder_morpholo1.59173936
32MP0000703_abnormal_thymus_morphology1.58576483
33MP0005379_endocrine/exocrine_gland_phen1.56810313
34MP0006292_abnormal_olfactory_placode1.53788407
35MP0003941_abnormal_skin_development1.50106571
36MP0004147_increased_porphyrin_level1.48516224
37MP0000313_abnormal_cell_death1.45586480
38MP0005551_abnormal_eye_electrophysiolog1.43962350
39MP0000689_abnormal_spleen_morphology1.42237585
40MP0003806_abnormal_nucleotide_metabolis1.41638846
41MP0002722_abnormal_immune_system1.41503544
42MP0003718_maternal_effect1.40485845
43MP0002019_abnormal_tumor_incidence1.38241200
44MP0005367_renal/urinary_system_phenotyp1.36168517
45MP0000516_abnormal_urinary_system1.36168517
46MP0002095_abnormal_skin_pigmentation1.33746664
47MP0000372_irregular_coat_pigmentation1.33041478
48MP0003315_abnormal_perineum_morphology1.30291636
49MP0005075_abnormal_melanosome_morpholog1.28112074
50MP0002139_abnormal_hepatobiliary_system1.28075682
51MP0001697_abnormal_embryo_size1.28004003
52MP0003186_abnormal_redox_activity1.27722733
53MP0001986_abnormal_taste_sensitivity1.27628352
54MP0008875_abnormal_xenobiotic_pharmacok1.26944686
55MP0001835_abnormal_antigen_presentation1.26118171
56MP0005646_abnormal_pituitary_gland1.24976999
57MP0002429_abnormal_blood_cell1.24413452
58MP0000647_abnormal_sebaceous_gland1.23516089
59MP0006036_abnormal_mitochondrial_physio1.23075412
60MP0001529_abnormal_vocalization1.22784987
61MP0000716_abnormal_immune_system1.20990034
62MP0002080_prenatal_lethality1.20594145
63MP0002876_abnormal_thyroid_physiology1.20185983
64MP0002090_abnormal_vision1.19426418
65MP0001293_anophthalmia1.17990095
66MP0001545_abnormal_hematopoietic_system1.17318793
67MP0005397_hematopoietic_system_phenotyp1.17318793
68MP0005380_embryogenesis_phenotype1.16865744
69MP0001672_abnormal_embryogenesis/_devel1.16865744
70MP0010307_abnormal_tumor_latency1.15696459
71MP0002938_white_spotting1.15326941
72MP0001800_abnormal_humoral_immune1.15021719
73MP0002210_abnormal_sex_determination1.14281604
74MP0003567_abnormal_fetal_cardiomyocyte1.12672721
75MP0005408_hypopigmentation1.09801422
76MP0002877_abnormal_melanocyte_morpholog1.09502059
77MP0001764_abnormal_homeostasis1.09413079
78MP0002138_abnormal_hepatobiliary_system1.09408951
79MP0003984_embryonic_growth_retardation1.08549014
80MP0001968_abnormal_touch/_nociception1.08307090
81MP0003011_delayed_dark_adaptation1.07488977
82MP0002751_abnormal_autonomic_nervous1.06475481
83MP0002420_abnormal_adaptive_immunity1.06246444
84MP0003121_genomic_imprinting1.06127230
85MP0005332_abnormal_amino_acid1.05404464
86MP0002088_abnormal_embryonic_growth/wei1.04850094
87MP0000631_abnormal_neuroendocrine_gland1.04522841
88MP0002234_abnormal_pharynx_morphology1.04114584
89MP0001188_hyperpigmentation1.03743853
90MP0000678_abnormal_parathyroid_gland1.03658775
91MP0009697_abnormal_copulation1.03370154
92MP0001819_abnormal_immune_cell1.03060671
93MP0003890_abnormal_embryonic-extraembry1.02641291
94MP0005174_abnormal_tail_pigmentation1.02212477
95MP0002723_abnormal_immune_serum1.02023739
96MP0002102_abnormal_ear_morphology1.01194021
97MP0002085_abnormal_embryonic_tissue1.00430680
98MP0003937_abnormal_limbs/digits/tail_de0.99987020
99MP0000427_abnormal_hair_cycle0.98940417
100MP0000685_abnormal_immune_system0.98591255
101MP0001929_abnormal_gametogenesis0.97839007
102MP0005391_vision/eye_phenotype0.96064601
103MP0005085_abnormal_gallbladder_physiolo0.94682311
104MP0001145_abnormal_male_reproductive0.94111878
105MP0003943_abnormal_hepatobiliary_system0.92910121
106MP0001485_abnormal_pinna_reflex0.92883584
107MP0010030_abnormal_orbit_morphology0.92393199
108MP0002405_respiratory_system_inflammati0.92302607
109MP0002452_abnormal_antigen_presenting0.91837239
110MP0000015_abnormal_ear_pigmentation0.91797706
111MP0001919_abnormal_reproductive_system0.91432132
112MP0002084_abnormal_developmental_patter0.91222343
113MP0001853_heart_inflammation0.91185216
114MP0005394_taste/olfaction_phenotype0.90125538
115MP0005499_abnormal_olfactory_system0.90125538
116MP0004019_abnormal_vitamin_homeostasis0.88687797
117MP0002132_abnormal_respiratory_system0.88192004
118MP0001984_abnormal_olfaction0.87780683
119MP0001873_stomach_inflammation0.87451193
120MP0006054_spinal_hemorrhage0.86177059
121MP0000653_abnormal_sex_gland0.84942395
122MP0002638_abnormal_pupillary_reflex0.84014689
123MP0002160_abnormal_reproductive_system0.83766478
124MP0005645_abnormal_hypothalamus_physiol0.83677710
125MP0005187_abnormal_penis_morphology0.83461800
126MP0008872_abnormal_physiological_respon0.83340851
127MP0000358_abnormal_cell_content/0.83308831
128MP0005000_abnormal_immune_tolerance0.81935202
129MP0004133_heterotaxia0.81345500
130MP0005636_abnormal_mineral_homeostasis0.81157421
131MP0001324_abnormal_eye_pigmentation0.80585209
132MP0006035_abnormal_mitochondrial_morpho0.80487843
133MP0001944_abnormal_pancreas_morphology0.79123815
134MP0000465_gastrointestinal_hemorrhage0.78961887
135MP0003136_yellow_coat_color0.78117570
136MP0010234_abnormal_vibrissa_follicle0.77860726
137MP0005025_abnormal_response_to0.77496300
138MP0004215_abnormal_myocardial_fiber0.77456944
139MP0001119_abnormal_female_reproductive0.77270277
140MP0004142_abnormal_muscle_tone0.76806331
141MP0002086_abnormal_extraembryonic_tissu0.76174112
142MP0004197_abnormal_fetal_growth/weight/0.74344635
143MP0009785_altered_susceptibility_to0.73880406
144MP0002277_abnormal_respiratory_mucosa0.73076440
145MP0004885_abnormal_endolymph0.72534672
146MP0003221_abnormal_cardiomyocyte_apopto0.72119509
147MP0003938_abnormal_ear_development0.70975461
148MP0003698_abnormal_male_reproductive0.70886978
149MP0005395_other_phenotype0.70743945
150MP0002928_abnormal_bile_duct0.69725203
151MP0002006_tumorigenesis0.69293899
152MP0005266_abnormal_metabolism0.67649738
153MP0000049_abnormal_middle_ear0.66066371
154MP0002163_abnormal_gland_morphology0.65634571
155MP0010352_gastrointestinal_tract_polyps0.65483281
156MP0002166_altered_tumor_susceptibility0.65063688
157MP0008789_abnormal_olfactory_epithelium0.63343579
158MP0005389_reproductive_system_phenotype0.60922605

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.33493119
2Abnormal number of erythroid precursors (HP:0012131)5.10494351
3Birth length less than 3rd percentile (HP:0003561)4.71341776
4Reticulocytopenia (HP:0001896)4.46156525
5Aplastic anemia (HP:0001915)4.04659368
6IgM deficiency (HP:0002850)4.01383594
7Acute encephalopathy (HP:0006846)3.66984002
8Thrombocytosis (HP:0001894)3.45778078
9Methylmalonic acidemia (HP:0002912)3.43324691
10Progressive macrocephaly (HP:0004481)3.40870269
11Colon cancer (HP:0003003)3.38631913
12Macrocytic anemia (HP:0001972)3.25990996
13Microvesicular hepatic steatosis (HP:0001414)3.23236928
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.15343718
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.15343718
16Oral leukoplakia (HP:0002745)3.02029455
17Pallor (HP:0000980)3.01791814
18Pendular nystagmus (HP:0012043)2.95329442
19Methylmalonic aciduria (HP:0012120)2.89958135
20Cerebral edema (HP:0002181)2.89582096
21Pancytopenia (HP:0001876)2.81829832
22Abnormality of methionine metabolism (HP:0010901)2.79911017
23Increased hepatocellular lipid droplets (HP:0006565)2.78946931
24Stenosis of the external auditory canal (HP:0000402)2.78576587
25Type I transferrin isoform profile (HP:0003642)2.78041844
26Rough bone trabeculation (HP:0100670)2.77136048
27Premature graying of hair (HP:0002216)2.72598171
28Type 2 muscle fiber atrophy (HP:0003554)2.69946832
29Hyperglycinemia (HP:0002154)2.68241740
30Abnormality of the heme biosynthetic pathway (HP:0010472)2.60348267
31B lymphocytopenia (HP:0010976)2.60098975
32Abnormality of B cell number (HP:0010975)2.60098975
33Cerebral hypomyelination (HP:0006808)2.59802197
34Abnormality of the labia minora (HP:0012880)2.59611101
35Degeneration of anterior horn cells (HP:0002398)2.58841151
36Abnormality of the anterior horn cell (HP:0006802)2.58841151
37Lactic acidosis (HP:0003128)2.56247884
38Microretrognathia (HP:0000308)2.54598396
39Abnormality of serum amino acid levels (HP:0003112)2.54538068
40Lipid accumulation in hepatocytes (HP:0006561)2.52465511
41Abnormality of aspartate family amino acid metabolism (HP:0010899)2.51734195
42Aplasia/hypoplasia of the uterus (HP:0008684)2.50933942
43Abnormal number of incisors (HP:0011064)2.49805027
44IgG deficiency (HP:0004315)2.49300742
45Breast hypoplasia (HP:0003187)2.48488329
46Selective tooth agenesis (HP:0001592)2.47069513
47Muscle fiber atrophy (HP:0100295)2.45484841
48Increased serum lactate (HP:0002151)2.45250802
49Exertional dyspnea (HP:0002875)2.45132615
5011 pairs of ribs (HP:0000878)2.41750591
51Abnormality of the ileum (HP:0001549)2.38489592
52Myelodysplasia (HP:0002863)2.38260395
53Patellar aplasia (HP:0006443)2.36740626
54Hepatocellular necrosis (HP:0001404)2.36447996
55Chromosomal breakage induced by crosslinking agents (HP:0003221)2.33573551
56Carpal bone hypoplasia (HP:0001498)2.33001330
57Lymphoma (HP:0002665)2.32409564
58Nephronophthisis (HP:0000090)2.30945582
59Mitochondrial inheritance (HP:0001427)2.28827475
60Abnormality of vitamin B metabolism (HP:0004340)2.27940240
61Abnormal protein glycosylation (HP:0012346)2.26327554
62Abnormal glycosylation (HP:0012345)2.26327554
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.26327554
64Abnormal protein N-linked glycosylation (HP:0012347)2.26327554
65Recurrent bronchitis (HP:0002837)2.24514571
66Abnormality of chromosome stability (HP:0003220)2.23975758
67Abnormality of T cell physiology (HP:0011840)2.23618262
68Medulloblastoma (HP:0002885)2.22509150
69Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22309742
70Hyperinsulinemic hypoglycemia (HP:0000825)2.21674680
71Aplasia/Hypoplasia of the patella (HP:0006498)2.21012148
72Increased CSF lactate (HP:0002490)2.19487940
73Renal Fanconi syndrome (HP:0001994)2.18190133
74Medial flaring of the eyebrow (HP:0010747)2.15888804
75Aplasia/Hypoplasia of the uvula (HP:0010293)2.14697779
76Lethargy (HP:0001254)2.13975437
77Amaurosis fugax (HP:0100576)2.11636352
78Megaloblastic anemia (HP:0001889)2.11432651
79Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.11406968
80Abnormality of homocysteine metabolism (HP:0010919)2.10999765
81Homocystinuria (HP:0002156)2.10999765
82Respiratory difficulties (HP:0002880)2.10327278
83Abnormal mitochondria in muscle tissue (HP:0008316)2.10326590
84True hermaphroditism (HP:0010459)2.09753212
85Increased serum pyruvate (HP:0003542)2.09666809
86Abnormality of glycolysis (HP:0004366)2.09666809
873-Methylglutaconic aciduria (HP:0003535)2.09417220
88Abnormality of T cells (HP:0002843)2.08450737
89Acute lymphatic leukemia (HP:0006721)2.07696150
90Abnormality of urine glucose concentration (HP:0011016)2.06081797
91Glycosuria (HP:0003076)2.06081797
92Intestinal atresia (HP:0011100)2.06038043
93Multiple enchondromatosis (HP:0005701)2.05875800
94Abnormality of midbrain morphology (HP:0002418)2.05053893
95Molar tooth sign on MRI (HP:0002419)2.05053893
96Basal cell carcinoma (HP:0002671)2.04803887
97Entropion (HP:0000621)2.03929031
98Progressive inability to walk (HP:0002505)2.03792559
99Increased intramyocellular lipid droplets (HP:0012240)2.03771678
100Aplasia/Hypoplasia of the sacrum (HP:0008517)2.03476005
101Respiratory failure (HP:0002878)2.03447454
102Abnormality of the preputium (HP:0100587)2.01762700
103Abnormality of renal resorption (HP:0011038)2.01096748
104Hypoglycemic coma (HP:0001325)2.00826263
105Oligodactyly (hands) (HP:0001180)2.00810167
106Abnormality of the vitamin B12 metabolism (HP:0004341)2.00809138
107Hepatic necrosis (HP:0002605)1.98829594
108Ragged-red muscle fibers (HP:0003200)1.98543690
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98537611
110Abnormality of alanine metabolism (HP:0010916)1.98537611
111Hyperalaninemia (HP:0003348)1.98537611
112Acute necrotizing encephalopathy (HP:0006965)1.97922885
113Abnormal lung lobation (HP:0002101)1.97918933
114Progressive muscle weakness (HP:0003323)1.95359256
115Absent thumb (HP:0009777)1.94669521
116Abnormality of the renal medulla (HP:0100957)1.93734103
117Poikiloderma (HP:0001029)1.93534245
118Abnormal trabecular bone morphology (HP:0100671)1.92410825
119Horseshoe kidney (HP:0000085)1.91838494
120Abnormality of serine family amino acid metabolism (HP:0010894)1.91656215
121Abnormality of glycine metabolism (HP:0010895)1.91656215
122Irregular epiphyses (HP:0010582)1.91208556
123Delayed CNS myelination (HP:0002188)1.91150496
124Cellular immunodeficiency (HP:0005374)1.90182003
125Secondary amenorrhea (HP:0000869)1.89619234
126Optic nerve coloboma (HP:0000588)1.88911408
127Abnormal biliary tract physiology (HP:0012439)1.88630949
128Bile duct proliferation (HP:0001408)1.88630949
129Hyperphosphaturia (HP:0003109)1.88563440
130Exercise intolerance (HP:0003546)1.88257800
131Sclerocornea (HP:0000647)1.88061743
132Chronic otitis media (HP:0000389)1.87433259
133Nephroblastoma (Wilms tumor) (HP:0002667)1.87015352
134Optic disc pallor (HP:0000543)1.86520067
135Abnormality of the renal collecting system (HP:0004742)1.86328605
136Hypoplasia of the uterus (HP:0000013)1.86243132
137Pancreatic fibrosis (HP:0100732)1.85846316
138Chromsome breakage (HP:0040012)1.85841683
139Leukodystrophy (HP:0002415)1.84809631
140Fair hair (HP:0002286)1.84673841
141Abnormality of sulfur amino acid metabolism (HP:0004339)1.84655640
142Reduced antithrombin III activity (HP:0001976)1.84312078
143Congenital primary aphakia (HP:0007707)1.82269289
144Bone marrow hypocellularity (HP:0005528)1.82019212
145Tubulointerstitial nephritis (HP:0001970)1.81309941
146Embryonal renal neoplasm (HP:0011794)1.80408704
147Volvulus (HP:0002580)1.80376500
148Poor head control (HP:0002421)1.79591638
149CNS demyelination (HP:0007305)1.79409902
150Rhabdomyosarcoma (HP:0002859)1.79268267
151Abnormality of the renal cortex (HP:0011035)1.79105363
152Meckel diverticulum (HP:0002245)1.78973117
153Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.78764855
154Pancreatic cysts (HP:0001737)1.78696506
155Aplasia/Hypoplasia of the thymus (HP:0010515)1.78586838
156Supernumerary spleens (HP:0009799)1.78549663
157Abnormality of the duodenum (HP:0002246)1.77819124
158Nephrogenic diabetes insipidus (HP:0009806)1.77487420
159Neoplasm of the adrenal gland (HP:0100631)1.76008816
160Duodenal stenosis (HP:0100867)1.75232096
161Small intestinal stenosis (HP:0012848)1.75232096
162Abolished electroretinogram (ERG) (HP:0000550)1.74815684

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.00732360
2WEE13.76391350
3ACVR1B3.39126565
4CDC73.28491701
5BRSK22.85372145
6TRIM282.80792798
7EIF2AK12.70974733
8NME22.62096146
9WNK32.61096377
10STK162.59098510
11TLK12.59068623
12TAOK22.49342415
13FRK2.45538435
14FLT32.40383866
15MKNK12.31957432
16MAP4K22.20992492
17NEK12.18955474
18EIF2AK32.16693693
19VRK12.15810247
20SRPK12.09597726
21VRK21.97743515
22MKNK21.93508666
23MAP4K11.87195538
24TGFBR11.77173267
25NEK21.76924910
26TSSK61.56565327
27MAP3K41.53701638
28PASK1.53122229
29SIK31.52478549
30PBK1.45724395
31PIM21.45642807
32RPS6KB21.39952639
33CDK71.35311637
34PLK41.34348115
35KIT1.33735897
36TXK1.33267870
37PLK11.32823568
38ATR1.31989706
39TEC1.31953787
40BRSK11.31775287
41MST41.30015235
42CDK81.24710812
43BLK1.23681024
44KDR1.18515803
45ZAP701.17544521
46MAP2K31.13358277
47AURKB1.10765093
48BRD41.10457095
49DYRK31.07714982
50ADRBK21.07559489
51GRK11.06714088
52MAPKAPK31.05288860
53PLK21.02651771
54TTK1.02151342
55ERBB31.01669947
56BCKDK0.99972451
57TAF10.99726438
58PNCK0.97503102
59CCNB10.96940673
60MAP2K70.96673857
61CDK190.91412602
62BTK0.88143319
63CDK40.87677681
64NME10.86359425
65BMPR1B0.85977571
66PDK20.84364398
67EIF2AK20.82937209
68PLK30.81653171
69CSF1R0.81284078
70MAP3K120.81254345
71CDK30.80757907
72CHEK20.80722392
73TNIK0.79777699
74PRPF4B0.79618471
75CSNK1G10.78645464
76STK100.78267807
77MINK10.77515345
78CHEK10.76147253
79LRRK20.75670474
80STK40.75038513
81MAP3K80.72112653
82JAK30.71952667
83PIM10.71311665
84DMPK0.71031002
85AURKA0.69375065
86PAK30.68526019
87CSNK1G20.68327465
88STK38L0.68001400
89TESK20.67316328
90NLK0.67174641
91STK240.66082308
92OXSR10.65635857
93CASK0.65040794
94CSNK2A20.62336893
95STK390.61061680
96ZAK0.60807858
97BCR0.60694997
98INSRR0.59924242
99NTRK30.59369275
100CDK120.58951182
101ALK0.58528276
102MAP2K60.58522142
103FGFR20.58320049
104ILK0.58047118
105RPS6KA50.57861102
106LIMK10.57716994
107ATM0.57536796
108CSNK2A10.57526834
109LYN0.56246537
110STK30.53947209
111CAMKK20.53849263
112IKBKE0.53677860
113LCK0.52023797
114OBSCN0.50773065
115CSNK1A1L0.50442407
116PRKCG0.49678994
117MAP3K30.49024156
118PRKCE0.48979077
119DYRK20.48801455
120SCYL20.48276865
121CSNK1E0.46564729
122NUAK10.46070509
123CLK10.45675882
124TYK20.45616895
125SYK0.44501750
126PINK10.44163835
127MAPK130.44158281
128WNK40.43952799
129PRKCI0.42348759
130CDK20.42115460
131TBK10.42058367
132MUSK0.41739470
133ITK0.40555416
134MATK0.40425496
135EEF2K0.39859773
136MAP3K110.38296258
137CSNK1A10.38004300
138RPS6KA40.37738501
139DAPK10.37549488
140UHMK10.36904066
141CSNK1G30.36688117
142YES10.36681952
143RAF10.33839510
144PHKG20.30258257
145PHKG10.30258257
146MAP3K50.29961171
147PRKDC0.26808238
148TIE10.24586037
149CDK10.23150688

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.67259284
2Ribosome_Homo sapiens_hsa030104.32253283
3RNA polymerase_Homo sapiens_hsa030203.94500897
4Mismatch repair_Homo sapiens_hsa034303.79463393
5Proteasome_Homo sapiens_hsa030503.49093097
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.37570226
7Spliceosome_Homo sapiens_hsa030403.02989769
8Homologous recombination_Homo sapiens_hsa034402.99048237
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.98985988
10Pyrimidine metabolism_Homo sapiens_hsa002402.76409980
11Base excision repair_Homo sapiens_hsa034102.73587174
12Nucleotide excision repair_Homo sapiens_hsa034202.62341712
13RNA transport_Homo sapiens_hsa030132.61684814
14Non-homologous end-joining_Homo sapiens_hsa034502.46950087
15Protein export_Homo sapiens_hsa030602.35907378
16Cell cycle_Homo sapiens_hsa041102.20007337
17Propanoate metabolism_Homo sapiens_hsa006402.12778721
18Basal transcription factors_Homo sapiens_hsa030222.07003295
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00326214
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.98924217
21RNA degradation_Homo sapiens_hsa030181.95587411
22One carbon pool by folate_Homo sapiens_hsa006701.90751658
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89824700
24Fanconi anemia pathway_Homo sapiens_hsa034601.73004960
25Sulfur metabolism_Homo sapiens_hsa009201.72478152
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.71705823
27Butanoate metabolism_Homo sapiens_hsa006501.65187788
28Purine metabolism_Homo sapiens_hsa002301.59975033
29Steroid biosynthesis_Homo sapiens_hsa001001.40573626
30Folate biosynthesis_Homo sapiens_hsa007901.38241393
31mRNA surveillance pathway_Homo sapiens_hsa030151.36521587
32Fatty acid elongation_Homo sapiens_hsa000621.36354331
33Pyruvate metabolism_Homo sapiens_hsa006201.35501829
34Caffeine metabolism_Homo sapiens_hsa002321.33206583
35Primary immunodeficiency_Homo sapiens_hsa053401.32155711
36Epstein-Barr virus infection_Homo sapiens_hsa051691.27670031
37Sulfur relay system_Homo sapiens_hsa041221.22300049
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.20628205
39Peroxisome_Homo sapiens_hsa041461.15148347
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14027363
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12587183
42Herpes simplex infection_Homo sapiens_hsa051681.11391270
43p53 signaling pathway_Homo sapiens_hsa041151.07123960
44Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05391819
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03285041
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96470054
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95269864
48Antigen processing and presentation_Homo sapiens_hsa046120.93947761
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90905358
50Tryptophan metabolism_Homo sapiens_hsa003800.90210571
51Systemic lupus erythematosus_Homo sapiens_hsa053220.86143611
52Parkinsons disease_Homo sapiens_hsa050120.84618820
53Fatty acid metabolism_Homo sapiens_hsa012120.82117595
54Huntingtons disease_Homo sapiens_hsa050160.81546475
55Pentose phosphate pathway_Homo sapiens_hsa000300.81377011
56N-Glycan biosynthesis_Homo sapiens_hsa005100.76009948
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75890540
58Retinol metabolism_Homo sapiens_hsa008300.75834362
59Fatty acid degradation_Homo sapiens_hsa000710.75030664
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73122378
61Nitrogen metabolism_Homo sapiens_hsa009100.72800122
62beta-Alanine metabolism_Homo sapiens_hsa004100.72628142
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71316528
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69085646
65Cardiac muscle contraction_Homo sapiens_hsa042600.68762395
66Hematopoietic cell lineage_Homo sapiens_hsa046400.68354824
67Collecting duct acid secretion_Homo sapiens_hsa049660.67660124
68Measles_Homo sapiens_hsa051620.65450054
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65446071
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.65445125
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65260984
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.64744666
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64151690
74Viral carcinogenesis_Homo sapiens_hsa052030.62731230
75Oxidative phosphorylation_Homo sapiens_hsa001900.60765438
76Phototransduction_Homo sapiens_hsa047440.60422560
77Vitamin B6 metabolism_Homo sapiens_hsa007500.59726218
78Linoleic acid metabolism_Homo sapiens_hsa005910.59353049
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.58717223
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58540758
81Chemical carcinogenesis_Homo sapiens_hsa052040.57430862
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57409678
83Selenocompound metabolism_Homo sapiens_hsa004500.57025367
84Arginine biosynthesis_Homo sapiens_hsa002200.52349399
85Oocyte meiosis_Homo sapiens_hsa041140.51390889
86HTLV-I infection_Homo sapiens_hsa051660.50420701
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48661477
88Vitamin digestion and absorption_Homo sapiens_hsa049770.48502340
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47448933
90Arginine and proline metabolism_Homo sapiens_hsa003300.47087994
91Biosynthesis of amino acids_Homo sapiens_hsa012300.47044000
92Glutathione metabolism_Homo sapiens_hsa004800.46838422
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46836463
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.45507469
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44475443
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.41002820
97Shigellosis_Homo sapiens_hsa051310.40719634
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40117166
99Ether lipid metabolism_Homo sapiens_hsa005650.39590381
100Galactose metabolism_Homo sapiens_hsa000520.38816123
101Thyroid cancer_Homo sapiens_hsa052160.38711354
102T cell receptor signaling pathway_Homo sapiens_hsa046600.38696401
103Metabolic pathways_Homo sapiens_hsa011000.38498558
104Allograft rejection_Homo sapiens_hsa053300.36290561
105Legionellosis_Homo sapiens_hsa051340.35508933
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.33672603
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32924787
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32817409
109Fat digestion and absorption_Homo sapiens_hsa049750.31827796
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31443284
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31352931
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31311411
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.31150542
114Alcoholism_Homo sapiens_hsa050340.28846690
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28790066
116Tyrosine metabolism_Homo sapiens_hsa003500.28489719
117Hepatitis B_Homo sapiens_hsa051610.27310482
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27082454
119Alzheimers disease_Homo sapiens_hsa050100.26180815
120Regulation of autophagy_Homo sapiens_hsa041400.24664497
121Apoptosis_Homo sapiens_hsa042100.24175628
122Fatty acid biosynthesis_Homo sapiens_hsa000610.23758388
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22600484
124Starch and sucrose metabolism_Homo sapiens_hsa005000.21763520
125Nicotine addiction_Homo sapiens_hsa050330.21436305
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21064362
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21062859
128B cell receptor signaling pathway_Homo sapiens_hsa046620.20256792
129Fructose and mannose metabolism_Homo sapiens_hsa000510.20155452
130Acute myeloid leukemia_Homo sapiens_hsa052210.19585129
131Carbon metabolism_Homo sapiens_hsa012000.19157787
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18863287
133Influenza A_Homo sapiens_hsa051640.18303940
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17114337
135TGF-beta signaling pathway_Homo sapiens_hsa043500.16094655
136Small cell lung cancer_Homo sapiens_hsa052220.13664715
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.12274087
138Type I diabetes mellitus_Homo sapiens_hsa049400.11339101
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10578462
140Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.10188745
141Maturity onset diabetes of the young_Homo sapiens_hsa049500.07320781
142Leishmaniasis_Homo sapiens_hsa051400.07100480
143Hepatitis C_Homo sapiens_hsa051600.06997166
144Arachidonic acid metabolism_Homo sapiens_hsa005900.06757647
145Colorectal cancer_Homo sapiens_hsa052100.05266027

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