PUS10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Pseudouridination, the isomerization of uridine to pseudouridine, is the most common posttranscriptional nucleotide modification found in RNA and is essential for biologic functions such as spliceosome biogenesis. Pseudouridylate synthases, such as PUS10, catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. These enzymes also act as RNA chaperones, facilitating the correct folding and assembly of tRNAs (McCleverty et al., 2007 [PubMed 17900615]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.90343853
2nuclear pore organization (GO:0006999)4.81087824
3folic acid-containing compound biosynthetic process (GO:0009396)4.54812035
4DNA unwinding involved in DNA replication (GO:0006268)4.26095799
5mitotic nuclear envelope disassembly (GO:0007077)4.04215986
6protein localization to kinetochore (GO:0034501)3.98305114
7indolalkylamine metabolic process (GO:0006586)3.96983685
8nucleobase biosynthetic process (GO:0046112)3.85749497
9DNA replication initiation (GO:0006270)3.77755979
10indole-containing compound catabolic process (GO:0042436)3.76396591
11indolalkylamine catabolic process (GO:0046218)3.76396591
12tryptophan catabolic process (GO:0006569)3.76396591
13membrane disassembly (GO:0030397)3.74972780
14nuclear envelope disassembly (GO:0051081)3.74972780
15positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.70646744
16pore complex assembly (GO:0046931)3.68958581
17DNA strand elongation involved in DNA replication (GO:0006271)3.68925675
18tryptophan metabolic process (GO:0006568)3.68808752
19fucose catabolic process (GO:0019317)3.62622526
20L-fucose metabolic process (GO:0042354)3.62622526
21L-fucose catabolic process (GO:0042355)3.62622526
22respiratory chain complex IV assembly (GO:0008535)3.56405925
23IMP biosynthetic process (GO:0006188)3.53790155
24DNA strand elongation (GO:0022616)3.53011075
25telomere maintenance via semi-conservative replication (GO:0032201)3.48755041
26mitotic sister chromatid cohesion (GO:0007064)3.48394844
27maturation of SSU-rRNA (GO:0030490)3.45225487
28telomere maintenance via recombination (GO:0000722)3.43573052
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.42516535
30NADH dehydrogenase complex assembly (GO:0010257)3.42516535
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42516535
32DNA replication-dependent nucleosome organization (GO:0034723)3.40434409
33DNA replication-dependent nucleosome assembly (GO:0006335)3.40434409
34cellular response to ethanol (GO:0071361)3.40213398
35positive regulation of natural killer cell differentiation (GO:0032825)3.39462143
36regulation of centriole replication (GO:0046599)3.38653549
37tetrahydrofolate metabolic process (GO:0046653)3.37968009
38mitotic recombination (GO:0006312)3.37107107
39histone-serine phosphorylation (GO:0035404)3.33112697
40DNA geometric change (GO:0032392)3.32770914
41DNA deamination (GO:0045006)3.32002226
42DNA duplex unwinding (GO:0032508)3.31622947
43protein localization to chromosome, centromeric region (GO:0071459)3.29952642
44mitotic chromosome condensation (GO:0007076)3.29611272
45cellular ketone body metabolic process (GO:0046950)3.27405018
46regulation of spindle organization (GO:0090224)3.25445607
47protein complex biogenesis (GO:0070271)3.24532791
48water-soluble vitamin biosynthetic process (GO:0042364)3.24401414
49purine nucleobase biosynthetic process (GO:0009113)3.23185993
50IMP metabolic process (GO:0046040)3.22573184
51peptidyl-histidine modification (GO:0018202)3.22531958
52response to pheromone (GO:0019236)3.20060531
53regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.19948545
54cytochrome complex assembly (GO:0017004)3.17270882
55folic acid metabolic process (GO:0046655)3.16768364
56kynurenine metabolic process (GO:0070189)3.16035317
57cellular response to exogenous dsRNA (GO:0071360)3.10881819
58mitochondrial respiratory chain complex assembly (GO:0033108)3.09393700
59regulation of histone H3-K9 methylation (GO:0051570)3.08773554
60S-adenosylmethionine metabolic process (GO:0046500)3.08600839
61mitotic metaphase plate congression (GO:0007080)3.07497720
62ribosomal small subunit assembly (GO:0000028)3.06097607
63preassembly of GPI anchor in ER membrane (GO:0016254)3.04942652
64formation of translation preinitiation complex (GO:0001731)3.04287911
65neural tube formation (GO:0001841)3.02383451
66DNA replication checkpoint (GO:0000076)3.02178068
67pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.02080328
68rRNA catabolic process (GO:0016075)3.02033140
69ribosome assembly (GO:0042255)3.01681505
70regulation of centrosome cycle (GO:0046605)3.00482264
71chromatin remodeling at centromere (GO:0031055)2.98046955
72CENP-A containing nucleosome assembly (GO:0034080)2.97859909
73C4-dicarboxylate transport (GO:0015740)2.95956128
74epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.93642501
75ubiquinone biosynthetic process (GO:0006744)2.91383104
76attachment of spindle microtubules to kinetochore (GO:0008608)2.90624566
77metaphase plate congression (GO:0051310)2.89515292
78behavioral response to nicotine (GO:0035095)2.89295811
79DNA replication-independent nucleosome organization (GO:0034724)2.89194330
80DNA replication-independent nucleosome assembly (GO:0006336)2.89194330
81kinetochore organization (GO:0051383)2.87639232
82pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.86436478
83UMP biosynthetic process (GO:0006222)2.86436478
84pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.86436478
85UMP metabolic process (GO:0046049)2.86436478
86quinone biosynthetic process (GO:1901663)2.83868972
87nuclear envelope organization (GO:0006998)2.82383687
88exogenous drug catabolic process (GO:0042738)2.82078246
89telomere maintenance via telomere lengthening (GO:0010833)2.81277535
90translesion synthesis (GO:0019985)2.81205265
91telomere maintenance (GO:0000723)2.80671261
92regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.80450799
93aromatic amino acid family catabolic process (GO:0009074)2.78587578
94DNA conformation change (GO:0071103)2.78518622
95ketone body metabolic process (GO:1902224)2.78161099
96DNA topological change (GO:0006265)2.78049241
97telomere organization (GO:0032200)2.77247177
98negative regulation of histone methylation (GO:0031061)2.76600043
99pteridine-containing compound biosynthetic process (GO:0042559)2.76459399
100somatic hypermutation of immunoglobulin genes (GO:0016446)2.76341788
101somatic diversification of immune receptors via somatic mutation (GO:0002566)2.76341788
102positive regulation of defense response to virus by host (GO:0002230)2.76313792
103nucleotide-excision repair, DNA gap filling (GO:0006297)2.74572609
104drug catabolic process (GO:0042737)2.73818190
105signal peptide processing (GO:0006465)2.73469281
106ubiquinone metabolic process (GO:0006743)2.71859821
107regulation of centrosome duplication (GO:0010824)2.71104076
108pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.70944534
109regulation of sister chromatid cohesion (GO:0007063)2.69777111
110histone exchange (GO:0043486)2.68816605
111high-density lipoprotein particle remodeling (GO:0034375)2.68344703
112positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.67954582
113RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.66098530
114regulation of translational fidelity (GO:0006450)2.65838446
115cholesterol efflux (GO:0033344)2.65429852
116regulation of mitotic spindle organization (GO:0060236)2.65224735
117mitochondrial RNA metabolic process (GO:0000959)2.64101765
118indole-containing compound metabolic process (GO:0042430)2.63429388
119folic acid-containing compound metabolic process (GO:0006760)2.63267238
120chromatin assembly or disassembly (GO:0006333)2.61543242
121meiotic chromosome segregation (GO:0045132)2.61435437
122glycine metabolic process (GO:0006544)2.61288461
123transcription from mitochondrial promoter (GO:0006390)2.59799506
124regulation of DNA endoreduplication (GO:0032875)2.59786225
125chromatin assembly (GO:0031497)2.58615035
126amine catabolic process (GO:0009310)2.58175587
127cellular biogenic amine catabolic process (GO:0042402)2.58175587
128kidney morphogenesis (GO:0060993)2.57612301
129establishment of chromosome localization (GO:0051303)2.56895081
130piRNA metabolic process (GO:0034587)2.56835944
131positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.54005616
132L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.53244548
133NAD biosynthetic process (GO:0009435)2.52969233
134postreplication repair (GO:0006301)2.52643128
135one-carbon metabolic process (GO:0006730)2.52491930
136regulation of natural killer cell differentiation (GO:0032823)2.52323301
137intestinal cholesterol absorption (GO:0030299)2.51709762
138NIK/NF-kappaB signaling (GO:0038061)2.50912972
139regulation of B cell receptor signaling pathway (GO:0050855)2.50125558
140ribosomal large subunit biogenesis (GO:0042273)2.49305094
141amino acid salvage (GO:0043102)2.48581886
142L-methionine salvage (GO:0071267)2.48581886
143L-methionine biosynthetic process (GO:0071265)2.48581886
144regulation of translational termination (GO:0006449)2.48200947
145somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.47433082
146isotype switching (GO:0045190)2.47433082
147somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.47433082
148spindle checkpoint (GO:0031577)2.47422229
149regulation of helicase activity (GO:0051095)2.46660012
150histone mRNA catabolic process (GO:0071044)2.46307791
151protein localization to chromosome (GO:0034502)2.45631618
152methionine biosynthetic process (GO:0009086)2.45319161
153detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.44376159
154regulation of chromosome segregation (GO:0051983)2.44023373
155exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.43847465
156serine family amino acid biosynthetic process (GO:0009070)2.43293515
157tRNA methylation (GO:0030488)2.42626325
158tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.41923429
159RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.41923429
160negative regulation of RNA splicing (GO:0033119)2.41822628
161nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.40689123
162spindle assembly checkpoint (GO:0071173)2.39646044
163polyol catabolic process (GO:0046174)2.39410057
164protein K11-linked deubiquitination (GO:0035871)2.39397726
165DNA demethylation (GO:0080111)2.38888916
166positive regulation of protein homooligomerization (GO:0032464)2.37558487
167very-low-density lipoprotein particle assembly (GO:0034379)2.36974832
168regulation of hexokinase activity (GO:1903299)2.35947349
169regulation of glucokinase activity (GO:0033131)2.35947349
170chromosome segregation (GO:0007059)2.35843648
171ribosome biogenesis (GO:0042254)2.35432239
172reverse cholesterol transport (GO:0043691)2.35415896
173synapsis (GO:0007129)2.35022960
174recombinational repair (GO:0000725)2.34833637
175GPI anchor metabolic process (GO:0006505)2.34688506
176double-strand break repair via homologous recombination (GO:0000724)2.34583910
177plasma lipoprotein particle assembly (GO:0034377)2.33484392
178aromatic amino acid family metabolic process (GO:0009072)2.33080953
179reciprocal DNA recombination (GO:0035825)2.29661897
180reciprocal meiotic recombination (GO:0007131)2.29661897
181urate metabolic process (GO:0046415)2.28949953
182establishment of protein localization to mitochondrial membrane (GO:0090151)2.28913687
183sulfation (GO:0051923)2.28580065
184platelet dense granule organization (GO:0060155)2.28397415
185mannosylation (GO:0097502)2.26700715
186cellular response to dsRNA (GO:0071359)2.25541315
187prenylation (GO:0097354)2.24420952
188protein prenylation (GO:0018342)2.24420952
189protein-lipid complex remodeling (GO:0034368)2.23274813
190macromolecular complex remodeling (GO:0034367)2.23274813
191plasma lipoprotein particle remodeling (GO:0034369)2.23274813
192oxidative demethylation (GO:0070989)2.22553828
193interferon-gamma production (GO:0032609)2.22415452
194cilium or flagellum-dependent cell motility (GO:0001539)2.21917635
195negative regulation of DNA-dependent DNA replication (GO:2000104)2.21349186
196positive regulation of fatty acid transport (GO:2000193)2.20722899

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.36645643
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.86778702
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.84013142
4ZNF274_21170338_ChIP-Seq_K562_Hela3.54107460
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.49392810
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.94586541
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93021782
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.92043232
9VDR_22108803_ChIP-Seq_LS180_Human2.61825723
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.56156144
11IGF1R_20145208_ChIP-Seq_DFB_Human2.38875704
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33687222
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27350694
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.27121092
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26657595
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.26086084
17AR_21909140_ChIP-Seq_LNCAP_Human2.24144819
18GATA1_22025678_ChIP-Seq_K562_Human2.21225775
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.21111932
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16544419
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.08340790
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06517275
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05131460
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.03676833
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.91183321
26VDR_23849224_ChIP-Seq_CD4+_Human1.88999208
27EWS_26573619_Chip-Seq_HEK293_Human1.88403905
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86394842
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.86275448
30FUS_26573619_Chip-Seq_HEK293_Human1.83511463
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82939676
32ER_23166858_ChIP-Seq_MCF-7_Human1.80640099
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79006752
34XRN2_22483619_ChIP-Seq_HELA_Human1.73603368
35IRF1_19129219_ChIP-ChIP_H3396_Human1.73475319
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.71816202
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.69668113
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69611107
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68816442
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67061985
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66942634
42* FOXP3_21729870_ChIP-Seq_TREG_Human1.65785163
43* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.65060426
44ELK1_19687146_ChIP-ChIP_HELA_Human1.64874937
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64004993
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63969870
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62565360
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.62344576
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61907524
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61636399
51MYC_22102868_ChIP-Seq_BL_Human1.60682170
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60060601
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.60035462
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59008596
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58532606
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57916783
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.57827832
58P300_19829295_ChIP-Seq_ESCs_Human1.57444421
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56587545
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55945628
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53723954
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52477634
63ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.52384273
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51560410
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49371289
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.47458417
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44487907
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43974714
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43944973
70GATA3_26560356_Chip-Seq_TH2_Human1.42084738
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40270825
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.40173410
73TAF15_26573619_Chip-Seq_HEK293_Human1.39143989
74TFEB_21752829_ChIP-Seq_HELA_Human1.38983257
75DCP1A_22483619_ChIP-Seq_HELA_Human1.38963967
76CIITA_25753668_ChIP-Seq_RAJI_Human1.38929391
77EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38229903
78* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35908082
79YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35876654
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.34616259
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34434568
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34098664
83TP53_22573176_ChIP-Seq_HFKS_Human1.33578509
84NANOG_19829295_ChIP-Seq_ESCs_Human1.32905664
85SOX2_19829295_ChIP-Seq_ESCs_Human1.32905664
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31022963
87GBX2_23144817_ChIP-Seq_PC3_Human1.30084120
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30001728
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29896581
90TTF2_22483619_ChIP-Seq_HELA_Human1.28999250
91FOXA1_25329375_ChIP-Seq_VCAP_Human1.28803607
92FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28803607
93SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27645410
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26872192
95MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26432496
96GABP_19822575_ChIP-Seq_HepG2_Human1.25793671
97STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25439125
98* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23480920
99FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21380983
100MYC_18940864_ChIP-ChIP_HL60_Human1.21186158
101PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19956578
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19395100
103TCF4_22108803_ChIP-Seq_LS180_Human1.18785657
104KDM5A_27292631_Chip-Seq_BREAST_Human1.18596976
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18290198
106CBP_20019798_ChIP-Seq_JUKART_Human1.18290198
107BCAT_22108803_ChIP-Seq_LS180_Human1.18241521
108CDX2_22108803_ChIP-Seq_LS180_Human1.17531700
109AR_20517297_ChIP-Seq_VCAP_Human1.16948283
110FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16446991
111ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16223158
112STAT3_23295773_ChIP-Seq_U87_Human1.16108022
113GATA3_21878914_ChIP-Seq_MCF-7_Human1.15215748
114MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14296036
115OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14186151
116HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13911707
117SPI1_23547873_ChIP-Seq_NB4_Human1.13877782
118SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12922171
119STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12871107
120NOTCH1_21737748_ChIP-Seq_TLL_Human1.10841061
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10777486
122KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09897478
123ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09531984
124MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09403482
125TCF4_23295773_ChIP-Seq_U87_Human1.08952902
126POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08472894
127CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08278248
128NCOR_22424771_ChIP-Seq_293T_Human1.08058701
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07957944
130IRF8_21731497_ChIP-ChIP_J774_Mouse1.07284493
131STAT3_18555785_Chip-Seq_ESCs_Mouse1.07101963
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06868951
133FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05894037
134AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05716340
135CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05440748
136HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04308576
137KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03813262
138ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03567645
139* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03207644
140HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02983785
141FLI1_21867929_ChIP-Seq_TH2_Mouse1.02015703
142PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01917718
143* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01498280
144P53_22387025_ChIP-Seq_ESCs_Mouse1.01395375
145MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00799027
146IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00194531
147MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98339165
148NANOG_18555785_Chip-Seq_ESCs_Mouse0.98166295
149SALL4_22934838_ChIP-ChIP_CD34+_Human0.98148549
150P300_18555785_Chip-Seq_ESCs_Mouse0.97769344
151BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97759010
152PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.96460969
153SRF_21415370_ChIP-Seq_HL-1_Mouse0.96440205
154PRDM14_20953172_ChIP-Seq_ESCs_Human0.96146090
155POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94427915
156SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.93878051
157MYB_26560356_Chip-Seq_TH1_Human0.91905519
158VDR_21846776_ChIP-Seq_THP-1_Human0.90777078
159* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90165395
160STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88996759
161NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.88296578
162CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87386944
163THAP11_20581084_ChIP-Seq_MESCs_Mouse0.86088236
164CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86031708
165CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85877886
166MYB_26560356_Chip-Seq_TH2_Human0.85418205
167NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84943152
168HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84941572
169CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84825540

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.93660580
2MP0010094_abnormal_chromosome_stability3.59182968
3MP0003693_abnormal_embryo_hatching3.26520438
4MP0003806_abnormal_nucleotide_metabolis3.22239433
5MP0003111_abnormal_nucleus_morphology3.08686239
6MP0004957_abnormal_blastocyst_morpholog2.91157440
7MP0003077_abnormal_cell_cycle2.83045324
8MP0008057_abnormal_DNA_replication2.78030842
9MP0008007_abnormal_cellular_replicative2.54867367
10MP0010352_gastrointestinal_tract_polyps2.48159884
11MP0004147_increased_porphyrin_level2.41868681
12MP0001986_abnormal_taste_sensitivity2.32526983
13MP0003646_muscle_fatigue2.29864291
14MP0002396_abnormal_hematopoietic_system2.28619485
15MP0008058_abnormal_DNA_repair2.17598948
16MP0005084_abnormal_gallbladder_morpholo2.16469577
17MP0010307_abnormal_tumor_latency2.08565324
18MP0004808_abnormal_hematopoietic_stem1.80215518
19MP0004043_abnormal_pH_regulation1.76227190
20MP0000569_abnormal_digit_pigmentation1.75634566
21MP0010329_abnormal_lipoprotein_level1.75241091
22MP0001666_abnormal_nutrient_absorption1.73485702
23MP0001730_embryonic_growth_arrest1.72694615
24MP0002139_abnormal_hepatobiliary_system1.62974716
25MP0005551_abnormal_eye_electrophysiolog1.62186990
26MP0003950_abnormal_plasma_membrane1.60012276
27MP0002102_abnormal_ear_morphology1.59862087
28MP0005671_abnormal_response_to1.56856918
29MP0003705_abnormal_hypodermis_morpholog1.56685889
30MP0000350_abnormal_cell_proliferation1.56281725
31MP0005332_abnormal_amino_acid1.53934360
32MP0001835_abnormal_antigen_presentation1.53844637
33MP0005360_urolithiasis1.53790637
34MP0002163_abnormal_gland_morphology1.53242906
35MP0005167_abnormal_blood-brain_barrier1.52862860
36MP0005379_endocrine/exocrine_gland_phen1.49714477
37MP0005076_abnormal_cell_differentiation1.44057236
38MP0004142_abnormal_muscle_tone1.42695290
39MP0006054_spinal_hemorrhage1.40268688
40MP0002876_abnormal_thyroid_physiology1.36843219
41MP0005387_immune_system_phenotype1.36122194
42MP0001790_abnormal_immune_system1.36122194
43MP0002132_abnormal_respiratory_system1.35059914
44MP0003724_increased_susceptibility_to1.34194273
45MP0008932_abnormal_embryonic_tissue1.33783159
46MP0002138_abnormal_hepatobiliary_system1.33644974
47MP0002166_altered_tumor_susceptibility1.29084752
48MP0003787_abnormal_imprinting1.28550535
49MP0005075_abnormal_melanosome_morpholog1.27077180
50MP0001672_abnormal_embryogenesis/_devel1.25698213
51MP0005380_embryogenesis_phenotype1.25698213
52MP0005389_reproductive_system_phenotype1.24978737
53MP0009764_decreased_sensitivity_to1.24756599
54MP0002019_abnormal_tumor_incidence1.24229779
55MP0009333_abnormal_splenocyte_physiolog1.24185184
56MP0002837_dystrophic_cardiac_calcinosis1.23936030
57MP0003436_decreased_susceptibility_to1.23282649
58MP0003718_maternal_effect1.22849623
59MP0002398_abnormal_bone_marrow1.21983689
60MP0000490_abnormal_crypts_of1.20289413
61MP0005085_abnormal_gallbladder_physiolo1.20100568
62MP0001919_abnormal_reproductive_system1.19689257
63MP0003984_embryonic_growth_retardation1.19530190
64MP0002086_abnormal_extraembryonic_tissu1.19294433
65MP0001697_abnormal_embryo_size1.18961982
66MP0004197_abnormal_fetal_growth/weight/1.18363055
67MP0003786_premature_aging1.18148817
68MP0002088_abnormal_embryonic_growth/wei1.17424231
69MP0002080_prenatal_lethality1.16212618
70MP0006036_abnormal_mitochondrial_physio1.16116561
71MP0003186_abnormal_redox_activity1.13636009
72MP0008877_abnormal_DNA_methylation1.12722154
73MP0000427_abnormal_hair_cycle1.12469188
74MP0004145_abnormal_muscle_electrophysio1.12100104
75MP0003123_paternal_imprinting1.11794081
76MP0003763_abnormal_thymus_physiology1.11405313
77MP0000015_abnormal_ear_pigmentation1.11234544
78MP0003567_abnormal_fetal_cardiomyocyte1.09188967
79MP0008872_abnormal_physiological_respon1.08313691
80MP0001800_abnormal_humoral_immune1.07469729
81MP0000372_irregular_coat_pigmentation1.06771905
82MP0005397_hematopoietic_system_phenotyp1.06251373
83MP0001545_abnormal_hematopoietic_system1.06251373
84MP0002722_abnormal_immune_system1.05659170
85MP0005365_abnormal_bile_salt1.05425178
86MP0001853_heart_inflammation1.05253323
87MP0002928_abnormal_bile_duct1.05067605
88MP0005645_abnormal_hypothalamus_physiol1.04831240
89MP0002148_abnormal_hypersensitivity_rea1.04643928
90MP0000689_abnormal_spleen_morphology1.04159676
91MP0000313_abnormal_cell_death1.02258520
92MP0000685_abnormal_immune_system1.01297140
93MP0000703_abnormal_thymus_morphology1.01118354
94MP0002095_abnormal_skin_pigmentation1.00347922
95MP0002006_tumorigenesis0.99815115
96MP0005410_abnormal_fertilization0.99390953
97MP0003566_abnormal_cell_adhesion0.98997987
98MP0002429_abnormal_blood_cell0.98091324
99MP0003183_abnormal_peptide_metabolism0.97531774
100MP0003868_abnormal_feces_composition0.97353600
101MP0009053_abnormal_anal_canal0.97053528
102MP0006292_abnormal_olfactory_placode0.96962981
103MP0002160_abnormal_reproductive_system0.96697236
104MP0009840_abnormal_foam_cell0.96581843
105MP0000598_abnormal_liver_morphology0.96499971
106MP0003656_abnormal_erythrocyte_physiolo0.96075314
107MP0005253_abnormal_eye_physiology0.95394742
108MP0003303_peritoneal_inflammation0.95208473
109MP0002452_abnormal_antigen_presenting0.94767780
110MP0003122_maternal_imprinting0.94439567
111MP0002877_abnormal_melanocyte_morpholog0.94299043
112MP0010234_abnormal_vibrissa_follicle0.94100049
113MP0003943_abnormal_hepatobiliary_system0.93441632
114MP0000716_abnormal_immune_system0.92675557
115MP0002084_abnormal_developmental_patter0.91966709
116MP0009697_abnormal_copulation0.91394849
117MP0005266_abnormal_metabolism0.91156480
118MP0000371_diluted_coat_color0.90896121
119MP0005636_abnormal_mineral_homeostasis0.90771234
120MP0003191_abnormal_cellular_cholesterol0.90571029
121MP0005023_abnormal_wound_healing0.88775297
122MP0006035_abnormal_mitochondrial_morpho0.88292727
123MP0005174_abnormal_tail_pigmentation0.87956616
124MP0003121_genomic_imprinting0.87689565
125MP0000609_abnormal_liver_physiology0.86984425
126MP0008469_abnormal_protein_level0.86898000
127MP0004947_skin_inflammation0.86044753
128MP0004264_abnormal_extraembryonic_tissu0.85135262
129MP0005464_abnormal_platelet_physiology0.84927060
130MP0005025_abnormal_response_to0.84581177
131MP0002085_abnormal_embryonic_tissue0.83935095
132MP0003890_abnormal_embryonic-extraembry0.83832766
133MP0002723_abnormal_immune_serum0.83526738
134MP0005646_abnormal_pituitary_gland0.83342641
135MP0001915_intracranial_hemorrhage0.83271750
136MP0001845_abnormal_inflammatory_respons0.82923711
137MP0002693_abnormal_pancreas_physiology0.82811341
138MP0009785_altered_susceptibility_to0.82555148
139MP0002420_abnormal_adaptive_immunity0.81904376
140MP0006072_abnormal_retinal_apoptosis0.81776171
141MP0001819_abnormal_immune_cell0.81341522
142MP0005647_abnormal_sex_gland0.80691739
143MP0002419_abnormal_innate_immunity0.80550597
144MP0009046_muscle_twitch0.80528635
145MP0000465_gastrointestinal_hemorrhage0.80265404
146MP0002118_abnormal_lipid_homeostasis0.79857378
147MP0002254_reproductive_system_inflammat0.79850903
148MP0002060_abnormal_skin_morphology0.79749202
149MP0001929_abnormal_gametogenesis0.77405358
150MP0004782_abnormal_surfactant_physiolog0.77094035
151MP0002405_respiratory_system_inflammati0.76699438
152MP0001764_abnormal_homeostasis0.76596248
153MP0005367_renal/urinary_system_phenotyp0.75846046
154MP0000516_abnormal_urinary_system0.75846046
155MP0005376_homeostasis/metabolism_phenot0.75560157
156MP0005000_abnormal_immune_tolerance0.75458593
157MP0003252_abnormal_bile_duct0.74796311
158MP0000858_altered_metastatic_potential0.74425618
159MP0009763_increased_sensitivity_to0.74192381
160MP0008438_abnormal_cutaneous_collagen0.73065192
161MP0008995_early_reproductive_senescence0.73038687
162MP0008875_abnormal_xenobiotic_pharmacok0.73010330
163MP0002277_abnormal_respiratory_mucosa0.72684029
164MP0001243_abnormal_dermal_layer0.72457151

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.20360822
2Birth length less than 3rd percentile (HP:0003561)3.86322534
33-Methylglutaconic aciduria (HP:0003535)3.65374488
4Pancreatic cysts (HP:0001737)3.60031186
5Abnormality of pyrimidine metabolism (HP:0004353)3.51433495
6Chromsome breakage (HP:0040012)3.43868092
7Abnormality of the renal cortex (HP:0011035)3.14096159
8Thrombocytosis (HP:0001894)3.11127497
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.08040783
10Congenital stationary night blindness (HP:0007642)3.04980183
11Reticulocytopenia (HP:0001896)3.03608627
12Recurrent gram-negative bacterial infections (HP:0005420)3.03334668
13Pancreatic fibrosis (HP:0100732)3.02843349
14True hermaphroditism (HP:0010459)3.00823230
15Renal cortical cysts (HP:0000803)2.94207342
16Hyperglycinuria (HP:0003108)2.88485906
17Chronic hepatic failure (HP:0100626)2.85179898
18Abnormality of midbrain morphology (HP:0002418)2.84386143
19Molar tooth sign on MRI (HP:0002419)2.84386143
20Abnormality of chromosome stability (HP:0003220)2.78414277
21Acute myeloid leukemia (HP:0004808)2.76116749
22Abnormality of monocarboxylic acid metabolism (HP:0010996)2.72570774
23Myelodysplasia (HP:0002863)2.69820220
24Abnormality of alanine metabolism (HP:0010916)2.67010253
25Hyperalaninemia (HP:0003348)2.67010253
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.67010253
27Colon cancer (HP:0003003)2.65468333
28Increased CSF lactate (HP:0002490)2.64630230
29Recurrent viral infections (HP:0004429)2.60220047
30Recurrent bronchitis (HP:0002837)2.59936313
31Hypobetalipoproteinemia (HP:0003563)2.59684791
32Selective tooth agenesis (HP:0001592)2.59556344
33Abnormality of the anterior horn cell (HP:0006802)2.56861971
34Degeneration of anterior horn cells (HP:0002398)2.56861971
35Agnosia (HP:0010524)2.52727498
36Nephronophthisis (HP:0000090)2.48706507
37Ectopic kidney (HP:0000086)2.47998724
38Acute necrotizing encephalopathy (HP:0006965)2.45528331
39Prolonged partial thromboplastin time (HP:0003645)2.45104322
40Oral leukoplakia (HP:0002745)2.44203411
41Acute encephalopathy (HP:0006846)2.43229803
42Medulloblastoma (HP:0002885)2.41380661
43Abnormality of methionine metabolism (HP:0010901)2.40745026
44Spontaneous abortion (HP:0005268)2.39660537
45Stomatitis (HP:0010280)2.36806346
46Abnormality of the renal medulla (HP:0100957)2.36468642
47Abnormality of sulfur amino acid metabolism (HP:0004339)2.32979804
48Abnormal biliary tract physiology (HP:0012439)2.31647439
49Bile duct proliferation (HP:0001408)2.31647439
50Hypothermia (HP:0002045)2.31456262
51Abnormality of serine family amino acid metabolism (HP:0010894)2.31110483
52Abnormality of glycine metabolism (HP:0010895)2.31110483
53Hyperglycinemia (HP:0002154)2.30843634
54Abnormality of B cell number (HP:0010975)2.29029313
55Impulsivity (HP:0100710)2.27984409
56Medial flaring of the eyebrow (HP:0010747)2.27065468
57Increased serum lactate (HP:0002151)2.26907574
58Abnormality of cells of the erythroid lineage (HP:0012130)2.26643039
59Mitochondrial inheritance (HP:0001427)2.26630327
60Progressive macrocephaly (HP:0004481)2.25738198
61Volvulus (HP:0002580)2.25444847
62Abolished electroretinogram (ERG) (HP:0000550)2.24233823
63Breast hypoplasia (HP:0003187)2.22315025
64Duplicated collecting system (HP:0000081)2.21551705
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.21350075
66Recurrent fungal infections (HP:0002841)2.20771119
67Bone marrow hypocellularity (HP:0005528)2.16485432
68Spastic diplegia (HP:0001264)2.16397925
69Increased mean platelet volume (HP:0011877)2.14916135
70Abnormal number of erythroid precursors (HP:0012131)2.14785127
71Hypoplasia of the thymus (HP:0000778)2.14465883
72Hepatic necrosis (HP:0002605)2.13495066
73Fair hair (HP:0002286)2.12163438
74Attenuation of retinal blood vessels (HP:0007843)2.11747723
75Pallor (HP:0000980)2.11679824
76Eczematoid dermatitis (HP:0000976)2.11393405
77Tubular atrophy (HP:0000092)2.09761727
78Abnormality of the preputium (HP:0100587)2.09002014
79Abnormal biliary tract morphology (HP:0012440)2.08881774
80Absent thumb (HP:0009777)2.08605587
81Meckel diverticulum (HP:0002245)2.08453256
82Intrahepatic cholestasis (HP:0001406)2.07535258
83Hypoglycemic coma (HP:0001325)2.06617502
84Abnormal platelet volume (HP:0011876)2.06188624
85High pitched voice (HP:0001620)2.05406836
86Abnormal delayed hypersensitivity skin test (HP:0002963)2.05302656
87Ependymoma (HP:0002888)2.05148577
88Rhabdomyosarcoma (HP:0002859)2.03201518
89Panhypogammaglobulinemia (HP:0003139)2.02255224
90Abnormal mitochondria in muscle tissue (HP:0008316)2.00759822
91Abnormality of urine glucose concentration (HP:0011016)2.00529800
92Glycosuria (HP:0003076)2.00529800
93Furrowed tongue (HP:0000221)1.98896911
94Lipid accumulation in hepatocytes (HP:0006561)1.98795138
95Pancytopenia (HP:0001876)1.98449057
96Deviation of the thumb (HP:0009603)1.97597034
97Proximal placement of thumb (HP:0009623)1.96958350
98Generalized aminoaciduria (HP:0002909)1.96281360
99Abnormality of the ileum (HP:0001549)1.95410042
100Abnormality of the fingertips (HP:0001211)1.94764099
101B lymphocytopenia (HP:0010976)1.93657667
102T lymphocytopenia (HP:0005403)1.91600252
103Pendular nystagmus (HP:0012043)1.91559259
104Lethargy (HP:0001254)1.91127790
105Abnormality of T cell number (HP:0011839)1.91013584
106Type II lissencephaly (HP:0007260)1.90064277
107Progressive inability to walk (HP:0002505)1.89931358
108Abnormality of aspartate family amino acid metabolism (HP:0010899)1.89805719
109Sloping forehead (HP:0000340)1.89577822
110Hyperventilation (HP:0002883)1.87893523
111IgA deficiency (HP:0002720)1.87124000
112Amaurosis fugax (HP:0100576)1.87116516
113Ketosis (HP:0001946)1.86731466
114Premature graying of hair (HP:0002216)1.86692145
115Congenital, generalized hypertrichosis (HP:0004540)1.86666765
116Methylmalonic acidemia (HP:0002912)1.86290571
117Abnormality of DNA repair (HP:0003254)1.85897987
118Hepatocellular necrosis (HP:0001404)1.85881196
119Basal cell carcinoma (HP:0002671)1.85700904
120Osteomyelitis (HP:0002754)1.85262029
121Cerebral edema (HP:0002181)1.85231484
122Squamous cell carcinoma (HP:0002860)1.84610135
123Increased hepatocellular lipid droplets (HP:0006565)1.84102797
124Lymphoma (HP:0002665)1.83928521
125Abnormality of serum amino acid levels (HP:0003112)1.83751850
126Abnormal spermatogenesis (HP:0008669)1.83617149
127Lactic acidosis (HP:0003128)1.83018770
128Abnormal rod and cone electroretinograms (HP:0008323)1.82917343
129Stomach cancer (HP:0012126)1.82307188
130Abnormality of the renal collecting system (HP:0004742)1.80654808
131Epidermoid cyst (HP:0200040)1.80390468
132Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80293247
133Metaphyseal dysplasia (HP:0100255)1.79627707
134Cutaneous melanoma (HP:0012056)1.79498368
135Cellular immunodeficiency (HP:0005374)1.79342908
136Methylmalonic aciduria (HP:0012120)1.78862653
137Small intestinal stenosis (HP:0012848)1.78860010
138Duodenal stenosis (HP:0100867)1.78860010
139Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78462671
140Elevated erythrocyte sedimentation rate (HP:0003565)1.78311460
141Absent/shortened dynein arms (HP:0200106)1.78095117
142Dynein arm defect of respiratory motile cilia (HP:0012255)1.78095117
143Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77634752
144Abnormal protein N-linked glycosylation (HP:0012347)1.77634752
145Abnormal protein glycosylation (HP:0012346)1.77634752
146Abnormal glycosylation (HP:0012345)1.77634752
147Cellulitis (HP:0100658)1.77532282
148Abnormality of vitamin B metabolism (HP:0004340)1.77445768
149Cystic liver disease (HP:0006706)1.77275690
150Megaloblastic anemia (HP:0001889)1.77232901
151Conjunctival telangiectasia (HP:0000524)1.77105147
152Acanthocytosis (HP:0001927)1.77032674
153Abnormality of the common coagulation pathway (HP:0010990)1.76830359
154Abnormality of the prostate (HP:0008775)1.76291496
155Autoimmune hemolytic anemia (HP:0001890)1.75972595
156Hypochromic microcytic anemia (HP:0004840)1.74345690
157Inability to walk (HP:0002540)1.72501239
158Hydroxyprolinuria (HP:0003080)1.72293617
159Abnormality of proline metabolism (HP:0010907)1.72293617
160Deep philtrum (HP:0002002)1.71845862
161Encephalitis (HP:0002383)1.71645656
162Biliary tract neoplasm (HP:0100574)1.71461990
163Type I transferrin isoform profile (HP:0003642)1.71296792
164Hypolipoproteinemia (HP:0010981)1.70628873
165Decreased electroretinogram (ERG) amplitude (HP:0000654)1.70486768
166Progressive microcephaly (HP:0000253)1.70138771
167Conjugated hyperbilirubinemia (HP:0002908)1.69233374
168Abnormality of T cells (HP:0002843)1.69093246
169Abnormality of the vitamin B12 metabolism (HP:0004341)1.68708879
170Acute hepatic failure (HP:0006554)1.68431988
171Periodontitis (HP:0000704)1.68095229
172Microvesicular hepatic steatosis (HP:0001414)1.67891533
173Nephrogenic diabetes insipidus (HP:0009806)1.67758884
174Homocystinuria (HP:0002156)1.67397156
175Abnormality of homocysteine metabolism (HP:0010919)1.67397156
176Male pseudohermaphroditism (HP:0000037)1.67303862
177Polydipsia (HP:0001959)1.67027635
178Abnormal drinking behavior (HP:0030082)1.67027635
179Ketoacidosis (HP:0001993)1.66896175
180Myocardial infarction (HP:0001658)1.66136504
181Neoplasm of the pancreas (HP:0002894)1.66049666
182Recurrent bacterial skin infections (HP:0005406)1.64973646
183Abnormality of reticulocytes (HP:0004312)1.64869849
184Long eyelashes (HP:0000527)1.64692095
185Hypochromic anemia (HP:0001931)1.64201120
186Chronic mucocutaneous candidiasis (HP:0002728)1.63766503
187Recurrent cutaneous fungal infections (HP:0011370)1.63766503
188Decreased central vision (HP:0007663)1.63154776
189Ureteral duplication (HP:0000073)1.62137729
190Abnormality of the vasculature of the conjunctiva (HP:0008054)1.61047206
191Abnormality of T cell physiology (HP:0011840)1.60238080
192Supernumerary spleens (HP:0009799)1.59490767
193Blepharitis (HP:0000498)1.58732077
194Increased nuchal translucency (HP:0010880)1.58568304
195Leukopenia (HP:0001882)1.58091116
196Ascites (HP:0001541)1.56465326
197Leukocytosis (HP:0001974)1.56128641

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.86319373
2CDC73.43134836
3TAOK33.26886410
4BRSK23.11708926
5BUB12.84711167
6BMPR1B2.80569648
7NUAK12.73563351
8NEK22.65365920
9EIF2AK12.51605573
10MST42.47358163
11RPS6KA42.39317950
12ADRBK22.16614162
13CAMKK22.16271062
14ACVR1B2.12179263
15CDK121.99073797
16WNK41.92035882
17STK101.91722404
18TXK1.91245041
19GRK11.83215597
20IRAK41.78698495
21SRPK11.72469200
22PASK1.71628442
23SCYL21.69041901
24TTK1.68011294
25INSRR1.65153090
26ATR1.64322656
27EIF2AK31.57654267
28MKNK11.57154592
29STK41.55393501
30FLT31.53177616
31AURKB1.51912586
32MAP4K21.50136523
33ZAK1.48133585
34RPS6KB21.47361667
35MAP3K81.44375859
36AKT31.43600629
37PLK11.39977286
38MAP3K101.39848981
39PIK3CA1.37512755
40VRK11.37249871
41TYK21.34796638
42WNK31.33535814
43PIK3CG1.28655341
44TLK11.28305815
45TSSK61.27911675
46NEK11.27828081
47MAP2K31.26803445
48PINK11.25507148
49TGFBR11.24095179
50EEF2K1.23682072
51MAP3K141.23639279
52CDK71.20484128
53STK391.20447764
54KIT1.19850088
55NEK91.19704260
56MAP3K41.17570783
57TEC1.17549874
58CDK41.16372728
59MKNK21.15711677
60DYRK31.14385597
61BCR1.13745205
62PLK31.11452349
63BRSK11.11255804
64LRRK21.10946841
65JAK31.10797326
66CDK61.10666052
67CHEK11.10539147
68PIM11.07490381
69MAP4K11.05051428
70PLK41.02937950
71TIE11.02352687
72PKN21.01796796
73OXSR10.99144869
74BTK0.98816410
75STK30.96009750
76FGFR40.95990199
77MAPKAPK30.95897232
78SYK0.93217386
79IKBKE0.92969264
80ATM0.91380882
81CHUK0.89341123
82TAOK20.88284145
83CHEK20.87190064
84BLK0.86175207
85MAPK130.86009150
86PRKCQ0.85043494
87CSF1R0.84810155
88NME20.81384896
89STK160.81295540
90STK38L0.80698225
91BCKDK0.80419291
92MAP3K30.80253281
93BRD40.79925860
94IKBKB0.79811212
95STK240.79424071
96PAK30.76328915
97CAMK1D0.75647233
98MAPKAPK50.75247894
99FGFR10.74480911
100EIF2AK20.74171949
101PRKAA20.73886358
102PTK60.71187453
103PAK40.70240143
104NLK0.69331181
105FRK0.69286113
106CASK0.69245112
107CDK20.68789665
108CSK0.68107495
109TRIM280.67755855
110RPS6KA50.66858815
111LYN0.66379755
112IRAK10.66060249
113DAPK20.65585677
114ITK0.63363982
115PDK30.62096946
116PDK40.62096946
117EPHA20.62031550
118MATK0.61318408
119CSNK2A20.59484709
120AURKA0.58821208
121MTOR0.58245702
122GRK60.56915462
123FGFR30.56403169
124TESK10.55929070
125CSNK2A10.55741713
126TRPM70.55156325
127MAPK110.54809569
128LCK0.54114739
129PDK20.53643008
130CSNK1A1L0.53015507
131ERN10.52021313
132ALK0.52007282
133CDK10.51718362
134JAK10.50296270
135TNIK0.49849214
136CAMK1G0.49037306
137BMPR20.48992101
138MAP3K50.48336032
139PRKCE0.47097152
140RPS6KB10.45537106
141IGF1R0.45271390
142ZAP700.44947870
143MAP2K70.44923238
144TTN0.44763260
145WNK10.44152296
146ADRBK10.43716524
147CSNK1G10.43136639
148OBSCN0.41459469
149TESK20.39655583
150GRK70.39493281
151MAPKAPK20.39358391
152PTK2B0.37965907
153TBK10.37664692
154MAPK150.37166443
155RIPK40.35958887
156ABL10.35225897
157CSNK1G30.35126060
158RPS6KA10.34889826
159PRKACA0.33337515
160PRKCG0.32990143
161CSNK1G20.32409478
162ERBB30.32058253

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.83760624
2One carbon pool by folate_Homo sapiens_hsa006703.56973105
3Mismatch repair_Homo sapiens_hsa034303.32681494
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.77777005
5RNA transport_Homo sapiens_hsa030132.42756015
6Butanoate metabolism_Homo sapiens_hsa006502.34827051
7Base excision repair_Homo sapiens_hsa034102.34082245
8Protein export_Homo sapiens_hsa030602.31110943
9Homologous recombination_Homo sapiens_hsa034402.22177433
10Linoleic acid metabolism_Homo sapiens_hsa005912.15960591
11Spliceosome_Homo sapiens_hsa030402.15094457
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.12902143
13Nucleotide excision repair_Homo sapiens_hsa034202.11538568
14Selenocompound metabolism_Homo sapiens_hsa004502.09196760
15Cell cycle_Homo sapiens_hsa041102.06597550
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.03119781
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02168239
18Asthma_Homo sapiens_hsa053101.96681990
19Non-homologous end-joining_Homo sapiens_hsa034501.94964340
20Proteasome_Homo sapiens_hsa030501.88496007
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86695321
22Oxidative phosphorylation_Homo sapiens_hsa001901.80486963
23Systemic lupus erythematosus_Homo sapiens_hsa053221.69852047
24Allograft rejection_Homo sapiens_hsa053301.68262343
25Fanconi anemia pathway_Homo sapiens_hsa034601.60862397
26Pyrimidine metabolism_Homo sapiens_hsa002401.60461735
27Ribosome_Homo sapiens_hsa030101.60289098
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.56823360
29Type I diabetes mellitus_Homo sapiens_hsa049401.55836073
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.55434246
31Graft-versus-host disease_Homo sapiens_hsa053321.50605588
32Autoimmune thyroid disease_Homo sapiens_hsa053201.50110212
33RNA degradation_Homo sapiens_hsa030181.48592465
34Ether lipid metabolism_Homo sapiens_hsa005651.47384028
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.46676677
36p53 signaling pathway_Homo sapiens_hsa041151.45295145
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.40185996
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.38905794
39Parkinsons disease_Homo sapiens_hsa050121.36309160
40RNA polymerase_Homo sapiens_hsa030201.35487458
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33653061
42Phototransduction_Homo sapiens_hsa047441.25041239
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.23188233
44Antigen processing and presentation_Homo sapiens_hsa046121.21010932
45Herpes simplex infection_Homo sapiens_hsa051681.19092159
46Vitamin digestion and absorption_Homo sapiens_hsa049771.18123890
47Biosynthesis of amino acids_Homo sapiens_hsa012301.17621288
48Basal transcription factors_Homo sapiens_hsa030221.17460821
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16322471
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14048487
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11814715
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.11100354
53NF-kappa B signaling pathway_Homo sapiens_hsa040641.10496249
54Viral carcinogenesis_Homo sapiens_hsa052031.08033376
55Sulfur metabolism_Homo sapiens_hsa009201.07360666
56Legionellosis_Homo sapiens_hsa051341.07211174
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05601923
58mRNA surveillance pathway_Homo sapiens_hsa030151.04110195
59Fatty acid degradation_Homo sapiens_hsa000711.01924268
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01696551
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00220966
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99637801
63Pentose phosphate pathway_Homo sapiens_hsa000300.97451124
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.94891275
65Fatty acid elongation_Homo sapiens_hsa000620.92658044
66Fatty acid metabolism_Homo sapiens_hsa012120.91818627
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91738291
68Carbon metabolism_Homo sapiens_hsa012000.89939840
69Small cell lung cancer_Homo sapiens_hsa052220.89351560
70Lysine degradation_Homo sapiens_hsa003100.88192042
71Huntingtons disease_Homo sapiens_hsa050160.86651499
72Epstein-Barr virus infection_Homo sapiens_hsa051690.86463058
73Arachidonic acid metabolism_Homo sapiens_hsa005900.86406017
74Folate biosynthesis_Homo sapiens_hsa007900.86358926
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85228154
76Caffeine metabolism_Homo sapiens_hsa002320.83957292
77Measles_Homo sapiens_hsa051620.83871883
78Tryptophan metabolism_Homo sapiens_hsa003800.83605135
79Regulation of autophagy_Homo sapiens_hsa041400.82856164
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81053950
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80184333
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77277602
83Leishmaniasis_Homo sapiens_hsa051400.73254069
84HTLV-I infection_Homo sapiens_hsa051660.72640645
85Complement and coagulation cascades_Homo sapiens_hsa046100.72363373
86Arginine biosynthesis_Homo sapiens_hsa002200.71571793
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70298869
88Metabolic pathways_Homo sapiens_hsa011000.70220544
89Apoptosis_Homo sapiens_hsa042100.69821297
90Steroid biosynthesis_Homo sapiens_hsa001000.69473485
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68357954
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67112719
93Thyroid cancer_Homo sapiens_hsa052160.65027321
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64743971
95Rheumatoid arthritis_Homo sapiens_hsa053230.64523870
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62359107
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62318293
98Nitrogen metabolism_Homo sapiens_hsa009100.61604313
99Alzheimers disease_Homo sapiens_hsa050100.61544683
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61486495
101Glycerolipid metabolism_Homo sapiens_hsa005610.61316783
102Primary immunodeficiency_Homo sapiens_hsa053400.60768379
103Purine metabolism_Homo sapiens_hsa002300.59576606
104Pyruvate metabolism_Homo sapiens_hsa006200.58390313
105Histidine metabolism_Homo sapiens_hsa003400.58082402
106Peroxisome_Homo sapiens_hsa041460.57565947
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57223094
108Influenza A_Homo sapiens_hsa051640.57039674
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56156555
110MicroRNAs in cancer_Homo sapiens_hsa052060.55745824
111beta-Alanine metabolism_Homo sapiens_hsa004100.55492789
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.54453891
113Propanoate metabolism_Homo sapiens_hsa006400.54355445
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53743596
115Fatty acid biosynthesis_Homo sapiens_hsa000610.53377890
116Olfactory transduction_Homo sapiens_hsa047400.53037006
117ABC transporters_Homo sapiens_hsa020100.52224700
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51411894
119Staphylococcus aureus infection_Homo sapiens_hsa051500.50988451
120Sphingolipid metabolism_Homo sapiens_hsa006000.50166485
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48646942
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48576013
123Sulfur relay system_Homo sapiens_hsa041220.47642618
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46336356
125PPAR signaling pathway_Homo sapiens_hsa033200.46128486
126Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44454325
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44297785
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44278736
129Glutathione metabolism_Homo sapiens_hsa004800.44094955
130Toxoplasmosis_Homo sapiens_hsa051450.42202328
131Hepatitis B_Homo sapiens_hsa051610.41043752
132Starch and sucrose metabolism_Homo sapiens_hsa005000.39427698
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38667845
134Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38606562
135Hematopoietic cell lineage_Homo sapiens_hsa046400.38127518
136Retinol metabolism_Homo sapiens_hsa008300.35385639
137Fat digestion and absorption_Homo sapiens_hsa049750.34162969
138Viral myocarditis_Homo sapiens_hsa054160.33546621
139Chemical carcinogenesis_Homo sapiens_hsa052040.33502742
140Arginine and proline metabolism_Homo sapiens_hsa003300.33233866
141Tyrosine metabolism_Homo sapiens_hsa003500.31710432
142Acute myeloid leukemia_Homo sapiens_hsa052210.31243989
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.31049463
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.30464459

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