PURA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.11657084
2central nervous system myelination (GO:0022010)6.11657084
3cellular potassium ion homeostasis (GO:0030007)5.60360565
4neuron cell-cell adhesion (GO:0007158)5.39691221
5membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.24861046
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.16751511
7sodium ion export (GO:0071436)5.12848201
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.79679332
9presynaptic membrane assembly (GO:0097105)4.67272361
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.64148818
11glutamate secretion (GO:0014047)4.61588971
12fatty acid elongation (GO:0030497)4.56434598
13negative regulation of neurotransmitter transport (GO:0051589)4.50388280
14cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.49260357
15presynaptic membrane organization (GO:0097090)4.47505267
16long-chain fatty acid biosynthetic process (GO:0042759)4.39792243
17energy coupled proton transport, down electrochemical gradient (GO:0015985)4.33688348
18ATP synthesis coupled proton transport (GO:0015986)4.33688348
19relaxation of cardiac muscle (GO:0055119)4.20643114
20dopamine biosynthetic process (GO:0042416)4.11949362
21cellular sodium ion homeostasis (GO:0006883)4.11575453
22gamma-aminobutyric acid signaling pathway (GO:0007214)4.06760100
23potassium ion import (GO:0010107)3.99684130
24regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.88202124
25potassium ion homeostasis (GO:0055075)3.83922683
26transmission of nerve impulse (GO:0019226)3.81371059
27establishment of protein localization to mitochondrial membrane (GO:0090151)3.80061563
28respiratory electron transport chain (GO:0022904)3.79369235
29neuron recognition (GO:0008038)3.75820818
30electron transport chain (GO:0022900)3.70870777
31neuron remodeling (GO:0016322)3.69611471
32neuronal action potential propagation (GO:0019227)3.67122347
33myelination (GO:0042552)3.59860256
34cell communication by electrical coupling (GO:0010644)3.59410554
35vocalization behavior (GO:0071625)3.58266994
36negative regulation of synaptic transmission, GABAergic (GO:0032229)3.57217120
37negative regulation of cytosolic calcium ion concentration (GO:0051481)3.56523681
38ensheathment of neurons (GO:0007272)3.56514973
39axon ensheathment (GO:0008366)3.56514973
40positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.55546947
41positive regulation of synapse assembly (GO:0051965)3.48115283
42regulation of catecholamine metabolic process (GO:0042069)3.46964483
43regulation of dopamine metabolic process (GO:0042053)3.46964483
44regulation of clathrin-mediated endocytosis (GO:2000369)3.46573481
45ionotropic glutamate receptor signaling pathway (GO:0035235)3.42371374
46negative regulation of neurotransmitter secretion (GO:0046929)3.42056090
47dopamine transport (GO:0015872)3.40412962
48glutamate receptor signaling pathway (GO:0007215)3.37658231
49regulation of glutamate secretion (GO:0014048)3.34749879
50synaptic vesicle exocytosis (GO:0016079)3.33694414
51mating behavior (GO:0007617)3.33396412
52neurotransmitter catabolic process (GO:0042135)3.32340215
53relaxation of muscle (GO:0090075)3.31255458
54protein localization to synapse (GO:0035418)3.29061138
55membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.26835434
56neurotransmitter uptake (GO:0001504)3.24070131
57synaptic vesicle maturation (GO:0016188)3.18290177
58regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.15965481
59relaxation of smooth muscle (GO:0044557)3.13238670
60regulation of long-term neuronal synaptic plasticity (GO:0048169)3.13131756
61positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.11949176
62regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.10732527
63substantia nigra development (GO:0021762)3.09840929
64chaperone-mediated protein transport (GO:0072321)3.07809680
65regulation of ARF protein signal transduction (GO:0032012)3.05123150
66locomotory exploration behavior (GO:0035641)3.02805238
67neuron-neuron synaptic transmission (GO:0007270)3.01893759
68regulation of synaptic vesicle exocytosis (GO:2000300)3.01719760
69negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.01009598
70glycerophospholipid catabolic process (GO:0046475)3.00305948
71protein neddylation (GO:0045116)3.00233111
72regulation of protein kinase A signaling (GO:0010738)2.97633799
73regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.97565623
74positive regulation of action potential (GO:0045760)2.96964068
75cell communication involved in cardiac conduction (GO:0086065)2.96209567
76synaptic transmission, dopaminergic (GO:0001963)2.94487057
77positive regulation of potassium ion transmembrane transport (GO:1901381)2.94257271
78axonal fasciculation (GO:0007413)2.92200667
79regulation of neuronal synaptic plasticity (GO:0048168)2.91860774
80startle response (GO:0001964)2.91018708
81postsynaptic membrane organization (GO:0001941)2.91000601
82regulation of synaptic vesicle transport (GO:1902803)2.88794886
83regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.87376001
84regulation of cell communication by electrical coupling (GO:0010649)2.87368343
85regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.86778885
86oligodendrocyte differentiation (GO:0048709)2.86304411
87positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.85742385
88cellular response to epinephrine stimulus (GO:0071872)2.85586910
89serotonin metabolic process (GO:0042428)2.82816299
90regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.81811759
91response to histamine (GO:0034776)2.81482078
92positive regulation of potassium ion transport (GO:0043268)2.81157742
93regulation of short-term neuronal synaptic plasticity (GO:0048172)2.80446600
94regulation of energy homeostasis (GO:2000505)2.80402972
95ATP hydrolysis coupled proton transport (GO:0015991)2.80187555
96energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.80187555
97membrane repolarization during action potential (GO:0086011)2.79829391
98neurotransmitter secretion (GO:0007269)2.79792670
99cerebellar granule cell differentiation (GO:0021707)2.79012904
100negative regulation of dendrite morphogenesis (GO:0050774)2.79001339
101positive regulation of muscle hypertrophy (GO:0014742)2.77764744
102positive regulation of cardiac muscle hypertrophy (GO:0010613)2.77764744
103urinary tract smooth muscle contraction (GO:0014848)2.75568914
104adult walking behavior (GO:0007628)2.75369716
105macroautophagy (GO:0016236)2.72484347
106synaptic transmission, glutamatergic (GO:0035249)2.71599120
107membrane depolarization during action potential (GO:0086010)2.70643088
108import into cell (GO:0098657)2.70440673
109regulation of collateral sprouting (GO:0048670)2.69277922
110response to epinephrine (GO:0071871)2.68670104
111negative regulation of protein localization to cell surface (GO:2000009)2.68160162
112negative regulation of synaptic transmission (GO:0050805)2.68157213
113positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.68134854
114regulation of glutamate receptor signaling pathway (GO:1900449)2.68081090
115regulation of feeding behavior (GO:0060259)2.68024231
116positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.67611405
117positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.66824668
118response to cocaine (GO:0042220)2.66761566
119regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.65261382
120synapse assembly (GO:0007416)2.65231770
121cytoskeletal anchoring at plasma membrane (GO:0007016)2.65098912
122regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.64897853
123response to methylmercury (GO:0051597)2.64492543
124righting reflex (GO:0060013)2.64365405
125Golgi to endosome transport (GO:0006895)2.64315011
126lipid translocation (GO:0034204)2.63695068
127phospholipid translocation (GO:0045332)2.63695068
128primary amino compound metabolic process (GO:1901160)2.63604490
129neurotransmitter transport (GO:0006836)2.63236850
130membrane assembly (GO:0071709)2.63099092
131cardiac conduction (GO:0061337)2.62275355
132regulation of excitatory postsynaptic membrane potential (GO:0060079)2.62234800
133hydrogen ion transmembrane transport (GO:1902600)2.61234071
134dendrite development (GO:0016358)2.60724679
135regulation of vesicle fusion (GO:0031338)2.60462884
136regulation of postsynaptic membrane potential (GO:0060078)2.60352418
137regulation of synapse assembly (GO:0051963)2.60143398
138establishment of protein localization to Golgi (GO:0072600)2.59502792
139behavioral response to cocaine (GO:0048148)2.59460746
140negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.59367147
141detection of calcium ion (GO:0005513)2.58739314
142regulation of voltage-gated calcium channel activity (GO:1901385)2.58694180
143phenol-containing compound catabolic process (GO:0019336)2.58494476
144L-amino acid import (GO:0043092)2.57137578
145myelin maintenance (GO:0043217)2.56829979
146G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56699396
147regulation of synaptic plasticity (GO:0048167)2.55280387
148cerebral cortex radially oriented cell migration (GO:0021799)2.55262700
149catecholamine biosynthetic process (GO:0042423)2.55235157
150catechol-containing compound biosynthetic process (GO:0009713)2.55235157
151interkinetic nuclear migration (GO:0022027)2.54743630
152long-term synaptic potentiation (GO:0060291)2.54572815
153positive regulation of sodium ion transport (GO:0010765)2.53570302
154catecholamine transport (GO:0051937)2.53287223
155inner mitochondrial membrane organization (GO:0007007)2.53008145
156gamma-aminobutyric acid transport (GO:0015812)2.52029547
157limb bud formation (GO:0060174)2.51033450
158maternal behavior (GO:0042711)2.50880459
159proline transport (GO:0015824)2.47463396
160regulation of sodium ion transmembrane transporter activity (GO:2000649)2.45227370
161cerebellar Purkinje cell differentiation (GO:0021702)2.45208171
162regulation of neurotransmitter secretion (GO:0046928)2.44169487
163regulation of sodium ion transmembrane transport (GO:1902305)2.42095880
164regulation of neurotransmitter transport (GO:0051588)2.40262706
165membrane repolarization (GO:0086009)2.39427269
166potassium ion transmembrane transport (GO:0071805)2.39306483
167cellular potassium ion transport (GO:0071804)2.39306483
168inositol phosphate-mediated signaling (GO:0048016)2.38852216
169regulation of potassium ion transmembrane transport (GO:1901379)2.36972033
170regulation of dendritic spine development (GO:0060998)2.33659426
171regulation of Rac protein signal transduction (GO:0035020)2.32704344
172astrocyte differentiation (GO:0048708)2.31218182
173positive regulation of cation channel activity (GO:2001259)2.31165362
174positive regulation of synapse maturation (GO:0090129)2.30894905
175positive regulation of gluconeogenesis (GO:0045722)2.30790152
176regulation of potassium ion transmembrane transporter activity (GO:1901016)2.28883728
177regulation of calcium ion transmembrane transport (GO:1903169)2.28837422
178regulation of calcium ion transmembrane transporter activity (GO:1901019)2.28837422

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.73237355
2GBX2_23144817_ChIP-Seq_PC3_Human3.76415787
3TAF15_26573619_Chip-Seq_HEK293_Human3.35052955
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.82635607
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.79457694
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.70682441
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.46384449
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41151980
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.40275049
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.35458332
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35195880
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.31906203
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29417139
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.25965688
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22564750
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22564750
17ZNF217_24962896_ChIP-Seq_MCF-7_Human2.16045122
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14939907
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14454012
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12176359
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10439339
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08560838
23* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06687483
24VDR_22108803_ChIP-Seq_LS180_Human2.06206011
25FUS_26573619_Chip-Seq_HEK293_Human2.02053772
26GATA1_22025678_ChIP-Seq_K562_Human1.99701759
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99514394
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99060283
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.98297539
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93555884
31P300_19829295_ChIP-Seq_ESCs_Human1.91599202
32AR_21572438_ChIP-Seq_LNCaP_Human1.91037200
33AHR_22903824_ChIP-Seq_MCF-7_Human1.89731672
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.88978989
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86302096
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85099106
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.79087307
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.78600228
39* REST_21632747_ChIP-Seq_MESCs_Mouse1.78403742
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73139279
41ER_23166858_ChIP-Seq_MCF-7_Human1.71766302
42* RNF2_27304074_Chip-Seq_ESCs_Mouse1.70937058
43IGF1R_20145208_ChIP-Seq_DFB_Human1.68953746
44ARNT_22903824_ChIP-Seq_MCF-7_Human1.68591692
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.67625718
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67081830
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.65729093
48SMAD4_21799915_ChIP-Seq_A2780_Human1.62867867
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59195161
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59136419
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58109245
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57145311
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.54988422
54RNF2_27304074_Chip-Seq_NSC_Mouse1.53802146
55CTNNB1_20460455_ChIP-Seq_HCT116_Human1.53306529
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52649365
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48352890
58* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47142344
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.41141430
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40862092
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40511639
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40511639
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39564840
64FOXM1_26456572_ChIP-Seq_MCF-7_Human1.38748073
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38674251
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34120554
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.32699595
68ZNF274_21170338_ChIP-Seq_K562_Hela1.31986875
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31237784
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31052302
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.30544493
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30507814
73DROSHA_22980978_ChIP-Seq_HELA_Human1.29398086
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.28409215
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.27918283
76* REST_18959480_ChIP-ChIP_MESCs_Mouse1.27661304
77EWS_26573619_Chip-Seq_HEK293_Human1.26373748
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23029308
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22319550
80NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22165429
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21856353
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.20488412
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18383465
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17166775
85AR_25329375_ChIP-Seq_VCAP_Human1.16805403
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.16133098
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16017409
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15540767
89RUNX2_22187159_ChIP-Seq_PCA_Human1.15136895
90YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14426065
91* RARB_27405468_Chip-Seq_BRAIN_Mouse1.13248307
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13191983
93JUN_21703547_ChIP-Seq_K562_Human1.13151617
94TP53_18474530_ChIP-ChIP_U2OS_Human1.13141693
95STAT3_23295773_ChIP-Seq_U87_Human1.12964188
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10829517
97BCAT_22108803_ChIP-Seq_LS180_Human1.10796811
98CMYC_18555785_Chip-Seq_ESCs_Mouse1.09269016
99FOXA2_19822575_ChIP-Seq_HepG2_Human1.08399535
100CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08088750
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08025307
102TCF4_23295773_ChIP-Seq_U87_Human1.06225821
103TAL1_26923725_Chip-Seq_HPCs_Mouse1.05689236
104SOX2_21211035_ChIP-Seq_LN229_Gbm1.04867297
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04854213
106P53_22387025_ChIP-Seq_ESCs_Mouse1.04767225
107CJUN_26792858_Chip-Seq_BT549_Human1.04671144
108AR_19668381_ChIP-Seq_PC3_Human1.04372809
109ESR2_21235772_ChIP-Seq_MCF-7_Human1.03716150
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03294818
111TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03156761
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03005487
113KDM2B_26808549_Chip-Seq_REH_Human1.02980127
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02827527
115TP53_16413492_ChIP-PET_HCT116_Human1.02286067
116E2F1_18555785_Chip-Seq_ESCs_Mouse1.02219422
117SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02128413
118SMAD_19615063_ChIP-ChIP_OVARY_Human1.01611935
119WT1_19549856_ChIP-ChIP_CCG9911_Human1.00932578
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00811398
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.00722220
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00443622
123TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99833132
124P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99044606
125P300_18555785_Chip-Seq_ESCs_Mouse0.99033895
126CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98634433
127* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98604245
128AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97633873
129EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97196432
130TRIM28_21343339_ChIP-Seq_HEK293_Human0.97159648
131LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95003767
132MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94860198
133* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94834232

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.63523487
2MP0000569_abnormal_digit_pigmentation3.38089356
3MP0001529_abnormal_vocalization3.25964868
4MP0003635_abnormal_synaptic_transmissio2.91864217
5MP0009745_abnormal_behavioral_response2.89484536
6MP0001905_abnormal_dopamine_level2.84349419
7MP0004859_abnormal_synaptic_plasticity2.84100327
8MP0004270_analgesia2.80148020
9* MP0002064_seizures2.78002274
10MP0006276_abnormal_autonomic_nervous2.76274728
11MP0009046_muscle_twitch2.74691990
12MP0002272_abnormal_nervous_system2.70920122
13MP0001440_abnormal_grooming_behavior2.53505261
14MP0001486_abnormal_startle_reflex2.45853486
15MP0001968_abnormal_touch/_nociception2.45346929
16MP0000920_abnormal_myelination2.43392874
17MP0002572_abnormal_emotion/affect_behav2.39305810
18MP0005423_abnormal_somatic_nervous2.34122771
19MP0001501_abnormal_sleep_pattern2.28568904
20MP0002063_abnormal_learning/memory/cond2.26425100
21MP0002736_abnormal_nociception_after2.15403545
22MP0002734_abnormal_mechanical_nocicepti2.15060414
23MP0004142_abnormal_muscle_tone2.14276629
24MP0003879_abnormal_hair_cell2.08812640
25MP0003329_amyloid_beta_deposits2.01832037
26MP0004742_abnormal_vestibular_system2.00574440
27MP0002909_abnormal_adrenal_gland2.00067813
28MP0002067_abnormal_sensory_capabilities1.94926090
29MP0005409_darkened_coat_color1.94093973
30MP0003787_abnormal_imprinting1.93237299
31MP0002735_abnormal_chemical_nociception1.90502682
32MP0004036_abnormal_muscle_relaxation1.88415862
33MP0001970_abnormal_pain_threshold1.82406419
34MP0004084_abnormal_cardiac_muscle1.82402602
35MP0003136_yellow_coat_color1.82184535
36MP0002009_preneoplasia1.82181586
37MP0003045_fibrosis1.78228632
38MP0005386_behavior/neurological_phenoty1.77759753
39MP0004924_abnormal_behavior1.77759753
40MP0002733_abnormal_thermal_nociception1.77746827
41* MP0000778_abnormal_nervous_system1.76138212
42MP0005645_abnormal_hypothalamus_physiol1.62379324
43MP0005171_absent_coat_pigmentation1.61016524
44MP0001188_hyperpigmentation1.59878822
45MP0010234_abnormal_vibrissa_follicle1.58362764
46MP0004215_abnormal_myocardial_fiber1.57856482
47MP0003122_maternal_imprinting1.56822166
48MP0005551_abnormal_eye_electrophysiolog1.56134210
49MP0002822_catalepsy1.51905220
50MP0002557_abnormal_social/conspecific_i1.49755125
51MP0003690_abnormal_glial_cell1.48844753
52MP0009379_abnormal_foot_pigmentation1.45463965
53MP0002184_abnormal_innervation1.45213242
54MP0001984_abnormal_olfaction1.40780405
55MP0002837_dystrophic_cardiac_calcinosis1.38647635
56MP0005379_endocrine/exocrine_gland_phen1.38047592
57MP0005646_abnormal_pituitary_gland1.36161172
58MP0004130_abnormal_muscle_cell1.34140051
59MP0005503_abnormal_tendon_morphology1.33889150
60MP0000003_abnormal_adipose_tissue1.33112130
61MP0003634_abnormal_glial_cell1.31788173
62MP0004885_abnormal_endolymph1.31098372
63MP0002229_neurodegeneration1.30461998
64* MP0002066_abnormal_motor_capabilities/c1.27031392
65MP0001348_abnormal_lacrimal_gland1.26881989
66* MP0002882_abnormal_neuron_morphology1.26690359
67MP0004145_abnormal_muscle_electrophysio1.25181921
68MP0000955_abnormal_spinal_cord1.23714074
69MP0006072_abnormal_retinal_apoptosis1.23317166
70MP0004484_altered_response_of1.23294777
71MP0005174_abnormal_tail_pigmentation1.17609611
72MP0001963_abnormal_hearing_physiology1.16860628
73MP0001485_abnormal_pinna_reflex1.13703884
74MP0008569_lethality_at_weaning1.13128990
75MP0001502_abnormal_circadian_rhythm1.12726653
76MP0001765_abnormal_ion_homeostasis1.09525238
77MP0004147_increased_porphyrin_level1.08025689
78MP0005410_abnormal_fertilization1.07269183
79MP0002752_abnormal_somatic_nervous1.06922167
80MP0003632_abnormal_nervous_system1.05933403
81MP0003631_nervous_system_phenotype1.03561349
82MP0005275_abnormal_skin_tensile1.02745392
83MP0010352_gastrointestinal_tract_polyps1.01148528
84MP0000631_abnormal_neuroendocrine_gland1.00963733
85MP0002163_abnormal_gland_morphology0.98863480
86MP0005187_abnormal_penis_morphology0.98582585
87MP0001299_abnormal_eye_distance/0.98527600
88MP0003633_abnormal_nervous_system0.97233810
89MP0002876_abnormal_thyroid_physiology0.96218080
90MP0010386_abnormal_urinary_bladder0.95811267
91MP0002971_abnormal_brown_adipose0.94790371
92MP0005670_abnormal_white_adipose0.94352329
93MP0003123_paternal_imprinting0.93925224
94MP0000639_abnormal_adrenal_gland0.93078426
95MP0000015_abnormal_ear_pigmentation0.92855574
96MP0000026_abnormal_inner_ear0.92581245
97MP0005623_abnormal_meninges_morphology0.91914114
98MP0002166_altered_tumor_susceptibility0.90299848
99MP0002090_abnormal_vision0.90175097
100MP0005620_abnormal_muscle_contractility0.89979284
101MP0001756_abnormal_urination0.89457698
102MP0000604_amyloidosis0.88866146
103MP0001879_abnormal_lymphatic_vessel0.88483368
104* MP0002152_abnormal_brain_morphology0.85987784
105MP0008872_abnormal_physiological_respon0.85979673
106MP0001958_emphysema0.85945067
107MP0000462_abnormal_digestive_system0.84444264
108MP0002877_abnormal_melanocyte_morpholog0.83396705
109MP0005375_adipose_tissue_phenotype0.83122008
110MP0001944_abnormal_pancreas_morphology0.81479291
111MP0003950_abnormal_plasma_membrane0.81413972
112MP0002638_abnormal_pupillary_reflex0.78482997
113MP0001664_abnormal_digestion0.77934472
114MP0003938_abnormal_ear_development0.77685931
115MP0003705_abnormal_hypodermis_morpholog0.77192439
116MP0004381_abnormal_hair_follicle0.77005383
117MP0005535_abnormal_body_temperature0.76463373
118MP0005253_abnormal_eye_physiology0.76405449
119MP0010368_abnormal_lymphatic_system0.76389520
120MP0002160_abnormal_reproductive_system0.75920736
121MP0008438_abnormal_cutaneous_collagen0.75674791
122MP0010678_abnormal_skin_adnexa0.75626650
123MP0005195_abnormal_posterior_eye0.75340014
124MP0000427_abnormal_hair_cycle0.75223134
125MP0004134_abnormal_chest_morphology0.73811354
126MP0010329_abnormal_lipoprotein_level0.71818544
127MP0000681_abnormal_thyroid_gland0.71216752
128MP0002108_abnormal_muscle_morphology0.69598049
129MP0008874_decreased_physiological_sensi0.69485304
130MP0006138_congestive_heart_failure0.69036998
131MP0001943_abnormal_respiration0.68242686
132MP0000751_myopathy0.68046840
133MP0004085_abnormal_heartbeat0.67953948
134MP0000013_abnormal_adipose_tissue0.67891646
135MP0004811_abnormal_neuron_physiology0.67125934
136MP0001177_atelectasis0.66493556
137MP0001727_abnormal_embryo_implantation0.66393960
138MP0009780_abnormal_chondrocyte_physiolo0.65414504
139MP0000747_muscle_weakness0.64155256
140MP0001986_abnormal_taste_sensitivity0.63044858
141MP0002069_abnormal_eating/drinking_beha0.62676801
142MP0002332_abnormal_exercise_endurance0.60402700
143MP0005394_taste/olfaction_phenotype0.58443995
144MP0005499_abnormal_olfactory_system0.58443995
145MP0004043_abnormal_pH_regulation0.57068017

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.93299274
2Papilledema (HP:0001085)4.49227274
3Neurofibrillary tangles (HP:0002185)4.46754363
4Obstructive sleep apnea (HP:0002870)4.28941955
5Acute necrotizing encephalopathy (HP:0006965)4.24086920
6Degeneration of the lateral corticospinal tracts (HP:0002314)4.12544354
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.12544354
8Cerebral inclusion bodies (HP:0100314)3.89048571
9Action tremor (HP:0002345)3.84216900
10Bundle branch block (HP:0011710)3.76030767
11Progressive macrocephaly (HP:0004481)3.74416768
12Atonic seizures (HP:0010819)3.65889958
13Mitochondrial inheritance (HP:0001427)3.59414925
14Abnormal mitochondria in muscle tissue (HP:0008316)3.56143392
15Abnormal ciliary motility (HP:0012262)3.53089904
16Focal seizures (HP:0007359)3.44469312
17Parakeratosis (HP:0001036)3.29627723
18Acute encephalopathy (HP:0006846)3.29076011
19Hyperventilation (HP:0002883)3.27527046
20Limb dystonia (HP:0002451)3.22125749
21Peripheral hypomyelination (HP:0007182)3.19892978
22Abnormality of the corticospinal tract (HP:0002492)3.11201205
23Macroorchidism (HP:0000053)3.05536477
24Dysmetric saccades (HP:0000641)3.05166985
25Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.03302648
26Increased hepatocellular lipid droplets (HP:0006565)3.03080476
27Sensory axonal neuropathy (HP:0003390)3.02998308
28Abnormal respiratory motile cilium morphology (HP:0005938)3.02336850
29Abnormal respiratory epithelium morphology (HP:0012253)3.02336850
30Renal Fanconi syndrome (HP:0001994)3.01045574
31Visual hallucinations (HP:0002367)3.01001537
32Increased circulating renin level (HP:0000848)2.98321606
33Dialeptic seizures (HP:0011146)2.95434168
34Epileptic encephalopathy (HP:0200134)2.94395775
35Abnormal respiratory motile cilium physiology (HP:0012261)2.91517599
36Retinal dysplasia (HP:0007973)2.87696742
37Absent/shortened dynein arms (HP:0200106)2.85929981
38Dynein arm defect of respiratory motile cilia (HP:0012255)2.85929981
39Leukodystrophy (HP:0002415)2.82759061
40Absence seizures (HP:0002121)2.81990558
41Blue irides (HP:0000635)2.77185450
42Myokymia (HP:0002411)2.76753784
43Optic disc pallor (HP:0000543)2.76637839
44Protruding tongue (HP:0010808)2.72582050
45Increased CSF lactate (HP:0002490)2.70753640
46Overgrowth (HP:0001548)2.68171849
47Broad-based gait (HP:0002136)2.67900806
48Supranuclear gaze palsy (HP:0000605)2.66365083
49Epileptiform EEG discharges (HP:0011182)2.64663285
50Hyporeflexia of lower limbs (HP:0002600)2.59553539
51Progressive inability to walk (HP:0002505)2.59080442
52Generalized hypopigmentation of hair (HP:0011358)2.57028357
53Dysmetria (HP:0001310)2.56652297
54Hepatocellular necrosis (HP:0001404)2.56028843
55Gait imbalance (HP:0002141)2.49520496
56Postural instability (HP:0002172)2.48413590
57Vaginal atresia (HP:0000148)2.46992198
58Cerebral hemorrhage (HP:0001342)2.46625522
59Lipid accumulation in hepatocytes (HP:0006561)2.44749661
60Genital tract atresia (HP:0001827)2.44093256
61Abnormality of the ischium (HP:0003174)2.43946553
62Medial flaring of the eyebrow (HP:0010747)2.43113926
63Fair hair (HP:0002286)2.42573876
64Generalized tonic-clonic seizures (HP:0002069)2.41538192
65Hyperkalemia (HP:0002153)2.40196701
66Prolonged QT interval (HP:0001657)2.39447983
67Pheochromocytoma (HP:0002666)2.38258230
68Hypothermia (HP:0002045)2.35906686
69Progressive cerebellar ataxia (HP:0002073)2.35442854
70Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.34626380
71Short chin (HP:0000331)2.34608928
72Syncope (HP:0001279)2.33412718
73Humeroradial synostosis (HP:0003041)2.31417294
74Synostosis involving the elbow (HP:0003938)2.31417294
75Congenital primary aphakia (HP:0007707)2.29725414
76Abnormal pupillary function (HP:0007686)2.29050153
77Febrile seizures (HP:0002373)2.26615214
78Neuroendocrine neoplasm (HP:0100634)2.26391481
79Poor eye contact (HP:0000817)2.24217134
80Scanning speech (HP:0002168)2.22183968
81Clumsiness (HP:0002312)2.22181547
82EEG with generalized epileptiform discharges (HP:0011198)2.18834573
83Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.18529746
84Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.17633326
85Hypoplasia of the iris (HP:0007676)2.16416046
86Thickened helices (HP:0000391)2.14678903
87Abnormal hair whorl (HP:0010721)2.14383317
88Hyperthyroidism (HP:0000836)2.12651498
89Termporal pattern (HP:0011008)2.12187471
90Insidious onset (HP:0003587)2.12187471
91Rhinitis (HP:0012384)2.10836244
92Heart block (HP:0012722)2.10810374
93Anxiety (HP:0000739)2.09125892
94Diplopia (HP:0000651)2.08754461
95Abnormality of binocular vision (HP:0011514)2.08754461
96Cubitus valgus (HP:0002967)2.08320367
97Abnormality of renal resorption (HP:0011038)2.07933353
98Truncal ataxia (HP:0002078)2.07658640
99Metabolic alkalosis (HP:0200114)2.07398801
100Atrial fibrillation (HP:0005110)2.07284688
101Hemiparesis (HP:0001269)2.06620846
102Hyperglycemia (HP:0003074)2.06569792
103Polyphagia (HP:0002591)2.05524548
104X-linked dominant inheritance (HP:0001423)2.04715963
105Menstrual irregularities (HP:0000858)2.04148791
106Nephrogenic diabetes insipidus (HP:0009806)2.02174126
107Abnormal EKG (HP:0003115)2.01680914
1083-Methylglutaconic aciduria (HP:0003535)2.01228396
109Postural tremor (HP:0002174)2.00524427
110Akinesia (HP:0002304)1.99942046
111Excessive salivation (HP:0003781)1.99739253
112Drooling (HP:0002307)1.99739253
113Cerebral edema (HP:0002181)1.99449406
114Spastic gait (HP:0002064)1.97675552
115Abnormal atrioventricular conduction (HP:0005150)1.97038426
116Generalized myoclonic seizures (HP:0002123)1.96957077
117Hamartoma of the eye (HP:0010568)1.96835492
118Metaphyseal dysplasia (HP:0100255)1.96615816
119Absent speech (HP:0001344)1.96601769
120Subaortic stenosis (HP:0001682)1.95655166
121Abnormality of the left ventricular outflow tract (HP:0011103)1.95655166
122Esotropia (HP:0000565)1.94242365
123Widely spaced teeth (HP:0000687)1.93959888
124Hyperinsulinemic hypoglycemia (HP:0000825)1.93546264
125Gaze-evoked nystagmus (HP:0000640)1.93329060
126Genetic anticipation (HP:0003743)1.93222608
127Bradycardia (HP:0001662)1.92654701
128Abnormality of ocular smooth pursuit (HP:0000617)1.92258840
129Hypoplastic ischia (HP:0003175)1.92199573
130Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.92096531
131Dysdiadochokinesis (HP:0002075)1.91655070
132Impaired smooth pursuit (HP:0007772)1.91282657
133Cardiovascular calcification (HP:0011915)1.90661657
134Psychosis (HP:0000709)1.90296862
135Muscle hypertrophy of the lower extremities (HP:0008968)1.89163412
136Primary atrial arrhythmia (HP:0001692)1.88814903
137Inability to walk (HP:0002540)1.88399076
138Ventricular fibrillation (HP:0001663)1.87734559
139Congenital ichthyosiform erythroderma (HP:0007431)1.87527407
140Abnormality of glycolysis (HP:0004366)1.87090129
141Increased serum pyruvate (HP:0003542)1.87090129
142Respiratory failure (HP:0002878)1.86194812
143Amblyopia (HP:0000646)1.84614387
144Sudden death (HP:0001699)1.83859399
145Hypsarrhythmia (HP:0002521)1.83371649
146Sleep apnea (HP:0010535)1.82883328
147Increased intramyocellular lipid droplets (HP:0012240)1.82026172
148Intention tremor (HP:0002080)1.81931628
149Infantile muscular hypotonia (HP:0008947)1.80633726
150Autoamputation (HP:0001218)1.79797017
151Insulin-resistant diabetes mellitus (HP:0000831)1.79690998
152Status epilepticus (HP:0002133)1.76423149
153Impaired vibratory sensation (HP:0002495)1.75659871
154Atrioventricular canal defect (HP:0006695)1.74127538
155Truncal obesity (HP:0001956)1.73803822
156Volvulus (HP:0002580)1.72664424
157Mitral stenosis (HP:0001718)1.72645778
158Aortic aneurysm (HP:0004942)1.72064318
159Supraventricular tachycardia (HP:0004755)1.71856833
160Complete atrioventricular canal defect (HP:0001674)1.71676166
161Abnormality of the axillary hair (HP:0100134)1.70864399
162Abnormality of secondary sexual hair (HP:0009888)1.70864399
163Neonatal hypoglycemia (HP:0001998)1.70391712
164Vascular calcification (HP:0004934)1.70082562
165Ankyloglossia (HP:0010296)1.65560440
166Supraventricular arrhythmia (HP:0005115)1.64894773
167Bell-shaped thorax (HP:0001591)1.63648658

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.31376520
2AKT34.29520840
3PNCK4.29319162
4STK394.03249315
5CASK3.27005143
6OXSR13.03825609
7TNIK2.55885772
8MAP3K122.47599139
9EPHA42.37422585
10NTRK32.21113774
11MAPKAPK52.20344768
12LATS22.15091605
13MAP3K22.12374358
14SGK22.08379966
15MAP2K72.03221969
16CAMKK21.96373696
17MAP3K41.90411122
18NTRK11.83365361
19WNK41.83204470
20FGR1.79611606
21BCR1.74946268
22RIPK41.73724415
23CDK191.71256281
24NME11.66410862
25SGK31.65702036
26GRK71.64513526
27PKN11.59920825
28DMPK1.59823266
29GRK51.54190910
30CAMK2B1.50454823
31MST41.50136175
32DAPK21.47627917
33ADRBK21.44097110
34CSNK1G31.42428650
35MUSK1.42084351
36STK381.37752842
37FES1.36874244
38ARAF1.36524029
39CAMK2A1.36120230
40PBK1.36068659
41TRPM71.35350993
42NTRK21.34231360
43BMPR21.33003187
44MARK11.28793746
45STK31.27335432
46CAMK2D1.27089283
47MAP2K41.26474431
48PINK11.26255841
49CSNK1G21.26030877
50PLK21.25118150
51UHMK11.23652537
52BMPR1B1.21290325
53FGFR31.20285677
54CAMK11.15802862
55CAMKK11.14877686
56MINK11.13302901
57ROCK21.10669521
58MAPK151.10604084
59STK241.09196292
60PRKCH1.07121116
61MAPK121.05323171
62WNK11.04890807
63CSNK1G11.03304008
64MAP3K91.01985782
65PDGFRB1.00836674
66CDK50.99234367
67MAPK130.98488984
68NEK60.95951401
69PRKCE0.93871699
70FGFR20.93163616
71JAK10.91883842
72ACVR1B0.89782473
73EPHB10.89454614
74PTK2B0.88253647
75CAMK2G0.86509181
76OBSCN0.86424165
77PRKD30.85444889
78NLK0.83954512
79PAK30.83928431
80CDK120.83473593
81MAP3K70.82506864
82CSNK1A1L0.82043886
83HIPK20.80924132
84MAP3K130.79734783
85FER0.78913164
86IRAK20.76473958
87MAPK70.75987260
88CAMK40.73627325
89PRKCQ0.72346931
90PAK60.71053950
91CDK140.69944891
92MAPK100.69254385
93PRKCG0.68724182
94STK160.68667559
95ADRBK10.66007979
96PDK10.62476863
97CAMK1G0.61698417
98RET0.59900520
99PRPF4B0.59849574
100STK38L0.58449839
101PRKAA20.57862491
102RPS6KA30.57636143
103SGK2230.57572935
104SGK4940.57572935
105PDGFRA0.57095572
106CDK30.56528790
107RAF10.56149626
108NEK90.56120388
109CDK150.55567178
110CDK180.55090844
111MAP2K10.54947678
112TYRO30.54863792
113SIK20.54021088
114PRKG10.53600922
115MET0.52601252
116PRKACA0.52593845
117MYLK0.52339350
118LIMK10.51768082
119TNK20.51600575
120GRK60.51526250
121DYRK1A0.51226655
122MAP3K10.51168973
123PHKG10.50335500
124PHKG20.50335500
125CDK11A0.49162970
126PRKD20.49096268
127MAP3K60.48657436
128MELK0.48224823
129TAF10.48017625
130WNK30.44906205
131ERBB40.44625039
132CAMK1D0.44366594
133KSR10.44045078
134FYN0.43825396
135MOS0.42354323
136STK110.41976247
137EEF2K0.41280458
138PRKD10.40406138
139GRK10.39770688
140CSNK1A10.39585842
141LATS10.38766439
142RIPK10.38174150
143MARK20.37175045
144KSR20.36542100
145SGK10.36255812
146YES10.35923287
147CSNK1E0.35586025
148DYRK20.33584296
149PIK3CA0.31434318
150PRKCA0.29989845
151PDPK10.29835418

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.27677507
2Nicotine addiction_Homo sapiens_hsa050333.49095870
3Parkinsons disease_Homo sapiens_hsa050123.29086419
4Alzheimers disease_Homo sapiens_hsa050102.98351367
5Collecting duct acid secretion_Homo sapiens_hsa049662.48664512
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.46271323
7GABAergic synapse_Homo sapiens_hsa047272.26323519
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.25846978
9Huntingtons disease_Homo sapiens_hsa050162.22193264
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.21247868
11Serotonergic synapse_Homo sapiens_hsa047262.17854476
12Fatty acid elongation_Homo sapiens_hsa000622.06940206
13Glutamatergic synapse_Homo sapiens_hsa047242.03196150
14Synaptic vesicle cycle_Homo sapiens_hsa047211.97060202
15Morphine addiction_Homo sapiens_hsa050321.96451566
16Cardiac muscle contraction_Homo sapiens_hsa042601.95120599
17Amphetamine addiction_Homo sapiens_hsa050311.87841076
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.87592348
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82707008
20Circadian rhythm_Homo sapiens_hsa047101.80702612
21Taste transduction_Homo sapiens_hsa047421.79820036
22Long-term depression_Homo sapiens_hsa047301.76712600
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71371151
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66995182
25Long-term potentiation_Homo sapiens_hsa047201.63258944
26Cocaine addiction_Homo sapiens_hsa050301.62028523
27Circadian entrainment_Homo sapiens_hsa047131.60830216
28Steroid biosynthesis_Homo sapiens_hsa001001.60427904
29Salivary secretion_Homo sapiens_hsa049701.60389711
30Dopaminergic synapse_Homo sapiens_hsa047281.59687413
31Ether lipid metabolism_Homo sapiens_hsa005651.59337208
32Vibrio cholerae infection_Homo sapiens_hsa051101.57320780
33Protein export_Homo sapiens_hsa030601.56451020
34Renin secretion_Homo sapiens_hsa049241.55527128
35Phototransduction_Homo sapiens_hsa047441.45498787
36Vitamin B6 metabolism_Homo sapiens_hsa007501.37090643
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28423531
38Olfactory transduction_Homo sapiens_hsa047401.24984983
39Calcium signaling pathway_Homo sapiens_hsa040201.23869402
40Gastric acid secretion_Homo sapiens_hsa049711.21209849
41Axon guidance_Homo sapiens_hsa043601.20618872
42Cholinergic synapse_Homo sapiens_hsa047251.18837147
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.17165931
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16517004
45Glioma_Homo sapiens_hsa052141.13577186
46Bile secretion_Homo sapiens_hsa049761.13403256
47Rheumatoid arthritis_Homo sapiens_hsa053231.10294640
48Sulfur metabolism_Homo sapiens_hsa009201.07337920
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.04091913
50mTOR signaling pathway_Homo sapiens_hsa041501.03487145
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03189021
52Insulin secretion_Homo sapiens_hsa049111.02304264
53Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00870971
54Type II diabetes mellitus_Homo sapiens_hsa049301.00553048
55Oxytocin signaling pathway_Homo sapiens_hsa049210.98436865
56Glucagon signaling pathway_Homo sapiens_hsa049220.97669033
57Sphingolipid metabolism_Homo sapiens_hsa006000.95775125
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93886852
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.93493797
60Gap junction_Homo sapiens_hsa045400.85801497
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84333337
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79961088
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78849355
64GnRH signaling pathway_Homo sapiens_hsa049120.78137422
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77451386
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76832892
67Pancreatic secretion_Homo sapiens_hsa049720.76793876
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76132087
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73200311
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72064319
71African trypanosomiasis_Homo sapiens_hsa051430.71636264
72FoxO signaling pathway_Homo sapiens_hsa040680.71168368
73Insulin resistance_Homo sapiens_hsa049310.70703540
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70222577
75ABC transporters_Homo sapiens_hsa020100.67597822
76Histidine metabolism_Homo sapiens_hsa003400.67409580
77cAMP signaling pathway_Homo sapiens_hsa040240.67404401
78Protein digestion and absorption_Homo sapiens_hsa049740.67272406
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66621878
80Linoleic acid metabolism_Homo sapiens_hsa005910.66039209
81Butanoate metabolism_Homo sapiens_hsa006500.65977967
82Melanogenesis_Homo sapiens_hsa049160.65702873
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65409790
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62992292
85Focal adhesion_Homo sapiens_hsa045100.61870609
86Insulin signaling pathway_Homo sapiens_hsa049100.61545228
87Platelet activation_Homo sapiens_hsa046110.61276845
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.60971928
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59793868
90Dorso-ventral axis formation_Homo sapiens_hsa043200.59672914
91Estrogen signaling pathway_Homo sapiens_hsa049150.59260581
92AMPK signaling pathway_Homo sapiens_hsa041520.57574845
93Rap1 signaling pathway_Homo sapiens_hsa040150.57515330
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55612839
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55111419
96Prolactin signaling pathway_Homo sapiens_hsa049170.54102902
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.53750197
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53233484
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.53014902
100Tight junction_Homo sapiens_hsa045300.52185527
101Phagosome_Homo sapiens_hsa041450.51847358
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51597953
103Melanoma_Homo sapiens_hsa052180.50661692
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49917343
105ECM-receptor interaction_Homo sapiens_hsa045120.49722621
106Oocyte meiosis_Homo sapiens_hsa041140.48079323
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.48024610
108VEGF signaling pathway_Homo sapiens_hsa043700.47823529
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47790478
110Ras signaling pathway_Homo sapiens_hsa040140.47705777
111ErbB signaling pathway_Homo sapiens_hsa040120.45080453
112Alcoholism_Homo sapiens_hsa050340.44471287
113Non-small cell lung cancer_Homo sapiens_hsa052230.44385257
114Ovarian steroidogenesis_Homo sapiens_hsa049130.44176541
115Thyroid hormone synthesis_Homo sapiens_hsa049180.43545749
116Arginine biosynthesis_Homo sapiens_hsa002200.43252486
117Tyrosine metabolism_Homo sapiens_hsa003500.43134703
118Selenocompound metabolism_Homo sapiens_hsa004500.43017271
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42916938
120Fatty acid biosynthesis_Homo sapiens_hsa000610.42502615
121Renal cell carcinoma_Homo sapiens_hsa052110.42243840
122Endometrial cancer_Homo sapiens_hsa052130.42141634
123Arachidonic acid metabolism_Homo sapiens_hsa005900.42001225
124Autoimmune thyroid disease_Homo sapiens_hsa053200.41439524
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40645235
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.39785240
127Choline metabolism in cancer_Homo sapiens_hsa052310.39474463
128Nitrogen metabolism_Homo sapiens_hsa009100.38518140
129Proteoglycans in cancer_Homo sapiens_hsa052050.36095207
130Type I diabetes mellitus_Homo sapiens_hsa049400.33230609
131MAPK signaling pathway_Homo sapiens_hsa040100.31818900
132Metabolic pathways_Homo sapiens_hsa011000.31752506
133Dilated cardiomyopathy_Homo sapiens_hsa054140.30669789
134Wnt signaling pathway_Homo sapiens_hsa043100.30638363
135Mineral absorption_Homo sapiens_hsa049780.28260684
136Prion diseases_Homo sapiens_hsa050200.27970015
137Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27007003
138Hedgehog signaling pathway_Homo sapiens_hsa043400.23311248
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23096012
140Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.22017412
141Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20643445
142Inositol phosphate metabolism_Homo sapiens_hsa005620.19961280
143Arginine and proline metabolism_Homo sapiens_hsa003300.18336439

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