PTX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the pentraxin superfamily, whose members encode highly conserved multifunctional proteins. The encoded protein, like other members of this family, contains a conserved pentraxin domain at the C-terminus. The highest levels of expression of the protein were observed in bone marrow, small intestine and testes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratan sulfate catabolic process (GO:0042340)9.31689252
2skeletal muscle adaptation (GO:0043501)8.06495567
3cornea development in camera-type eye (GO:0061303)7.31028419
4negative regulation of stress fiber assembly (GO:0051497)6.70044666
5myoblast migration (GO:0051451)6.56081274
6neuronal ion channel clustering (GO:0045161)6.40922224
7peripheral nervous system axon ensheathment (GO:0032292)6.03797763
8myelination in peripheral nervous system (GO:0022011)6.03797763
9extracellular matrix assembly (GO:0085029)6.02196588
10negative regulation of actin filament bundle assembly (GO:0032232)5.88279323
11negative regulation of Rho protein signal transduction (GO:0035024)5.86581811
12positive regulation of B cell differentiation (GO:0045579)5.69992888
13positive regulation of gamma-delta T cell activation (GO:0046645)5.55754331
14negative regulation of phagocytosis (GO:0050765)5.49161677
15cellular extravasation (GO:0045123)5.45704536
16reactive oxygen species biosynthetic process (GO:1903409)5.18121784
17keratan sulfate biosynthetic process (GO:0018146)5.06574118
18respiratory burst (GO:0045730)5.05693499
19behavioral response to pain (GO:0048266)4.96092200
20negative regulation of interleukin-10 production (GO:0032693)4.82317821
21mannose metabolic process (GO:0006013)4.76480741
22protein heterotrimerization (GO:0070208)4.48757596
23response to peptidoglycan (GO:0032494)4.42819716
24vocalization behavior (GO:0071625)4.42344564
25positive regulation of interleukin-4 production (GO:0032753)4.37362177
26regulation of mitochondrial depolarization (GO:0051900)4.31564759
27negative regulation of erythrocyte differentiation (GO:0045647)4.27958842
28establishment of protein localization to mitochondrial membrane (GO:0090151)4.25270808
29complement activation, alternative pathway (GO:0006957)4.24651948
30keratan sulfate metabolic process (GO:0042339)4.22224693
31negative regulation of B cell apoptotic process (GO:0002903)4.21829551
32L-fucose catabolic process (GO:0042355)4.19354091
33fucose catabolic process (GO:0019317)4.19354091
34L-fucose metabolic process (GO:0042354)4.19354091
35regulation of B cell differentiation (GO:0045577)4.16389726
36striated muscle hypertrophy (GO:0014897)4.03885234
37NAD biosynthetic process (GO:0009435)3.99420939
38macrophage differentiation (GO:0030225)3.95769825
39cellular response to cadmium ion (GO:0071276)3.94851647
40positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.93906532
41cellular sodium ion homeostasis (GO:0006883)3.89764644
42regulation of gamma-delta T cell activation (GO:0046643)3.88184888
43negative regulation of growth of symbiont in host (GO:0044130)3.85961500
44negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.85961500
45modulation of growth of symbiont involved in interaction with host (GO:0044144)3.85961500
46regulation of growth of symbiont in host (GO:0044126)3.85961500
47regulation of gamma-delta T cell differentiation (GO:0045586)3.84594095
48dosage compensation (GO:0007549)3.84082001
49viral transcription (GO:0019083)3.81321522
50defense response to fungus (GO:0050832)3.80370332
51UTP biosynthetic process (GO:0006228)3.72774792
52negative regulation of cell-matrix adhesion (GO:0001953)3.70404330
53epithelial cell-cell adhesion (GO:0090136)3.70223017
54extracellular fibril organization (GO:0043206)3.66859530
55B cell receptor signaling pathway (GO:0050853)3.64750689
56UTP metabolic process (GO:0046051)3.64082628
57DNA unwinding involved in DNA replication (GO:0006268)3.61729332
58muscle hypertrophy (GO:0014896)3.61110615
59neutrophil activation involved in immune response (GO:0002283)3.58292119
60regulation of B cell apoptotic process (GO:0002902)3.55198803
61ionotropic glutamate receptor signaling pathway (GO:0035235)3.53583594
62T cell migration (GO:0072678)3.53352176
63translational termination (GO:0006415)3.52360921
64GTP biosynthetic process (GO:0006183)3.52022295
65muscle cell migration (GO:0014812)3.49451032
66DNA replication initiation (GO:0006270)3.43210480
67striated muscle adaptation (GO:0014888)3.42385939
68regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.42122074
69regulation of mast cell degranulation (GO:0043304)3.40865967
70peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.34917664
71DNA strand renaturation (GO:0000733)3.33965492
72collagen fibril organization (GO:0030199)3.33064083
73maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.29651658
74regulation of myeloid leukocyte mediated immunity (GO:0002886)3.29160419
75regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.28686012
76fibril organization (GO:0097435)3.26375601
77oxygen transport (GO:0015671)3.25556403
78regulation of fibroblast migration (GO:0010762)3.25445378
79sequestering of extracellular ligand from receptor (GO:0035581)3.25440207
80nicotinamide nucleotide biosynthetic process (GO:0019359)3.25341926
81pyridine nucleotide biosynthetic process (GO:0019363)3.25341926
82negative regulation of interleukin-6 production (GO:0032715)3.22501943
83cell wall macromolecule catabolic process (GO:0016998)3.21402705
84positive regulation of granulocyte differentiation (GO:0030854)3.20516561
85auditory receptor cell differentiation (GO:0042491)3.18802373
86regulation of leukocyte degranulation (GO:0043300)3.16564581
87positive regulation of focal adhesion assembly (GO:0051894)3.14366999
88positive regulation of cell junction assembly (GO:1901890)3.14366999
89fucosylation (GO:0036065)3.10763702
90positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.09984555
91short-term memory (GO:0007614)3.09591551
92inner ear receptor cell development (GO:0060119)3.07364107
93regulation of mast cell activation involved in immune response (GO:0033006)3.06923869
94leukocyte degranulation (GO:0043299)3.06454616
95regulation of interleukin-4 production (GO:0032673)3.06108216
96mast cell degranulation (GO:0043303)3.05350385
97mast cell activation involved in immune response (GO:0002279)3.05350385
98positive thymic T cell selection (GO:0045059)3.05098698
99regulation of complement activation (GO:0030449)3.04744919
100regulation of B cell receptor signaling pathway (GO:0050855)3.04508529
101bone trabecula formation (GO:0060346)3.03866064
102translational elongation (GO:0006414)3.01505810
103negative regulation of inclusion body assembly (GO:0090084)3.00183175
104DNA strand elongation involved in DNA replication (GO:0006271)2.99597739
105interleukin-1-mediated signaling pathway (GO:0070498)2.99151459
106positive regulation of cell adhesion mediated by integrin (GO:0033630)2.98841266
107response to muramyl dipeptide (GO:0032495)2.98692157
108positive regulation of adherens junction organization (GO:1903393)2.98301515
109regulation of hypersensitivity (GO:0002883)2.98020220
110negative regulation of T cell mediated immunity (GO:0002710)2.97780974
111regulation of plasminogen activation (GO:0010755)2.97338769
112ribosomal small subunit assembly (GO:0000028)2.96866812
113autophagic vacuole fusion (GO:0000046)2.96489282
114opioid receptor signaling pathway (GO:0038003)2.95218382
115tryptophan catabolic process (GO:0006569)2.94784733
116indole-containing compound catabolic process (GO:0042436)2.94784733
117indolalkylamine catabolic process (GO:0046218)2.94784733
118SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.94653217
119endothelial cell morphogenesis (GO:0001886)2.94604239
120muscle adaptation (GO:0043500)2.93508958
121regulation of glutamate receptor signaling pathway (GO:1900449)2.91889329
122cytolysis (GO:0019835)2.91648836
123positive regulation of neutrophil chemotaxis (GO:0090023)2.91383953
124positive regulation of neutrophil migration (GO:1902624)2.91383953
125locomotory exploration behavior (GO:0035641)2.90941452
126guanosine-containing compound biosynthetic process (GO:1901070)2.90556994
127response to fungus (GO:0009620)2.90335702
128regulation of histone phosphorylation (GO:0033127)2.90238222
129negative thymic T cell selection (GO:0045060)2.89514223
130dendritic spine morphogenesis (GO:0060997)2.88634927
131cotranslational protein targeting to membrane (GO:0006613)2.87628414
132protein targeting to ER (GO:0045047)2.84925381
133DNA strand elongation (GO:0022616)2.84513951
134leukocyte aggregation (GO:0070486)2.84481173
135sulfur compound catabolic process (GO:0044273)2.83808728
136detection of molecule of bacterial origin (GO:0032490)2.83106979
137G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.83061391
138regulation of regulated secretory pathway (GO:1903305)2.82953433
139embryonic retina morphogenesis in camera-type eye (GO:0060059)2.82468392
140negative regulation of granulocyte differentiation (GO:0030853)2.82154632
141positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.81926792
142inner mitochondrial membrane organization (GO:0007007)2.81316548
143innate immune response in mucosa (GO:0002227)2.80956805
144phosphatidylglycerol biosynthetic process (GO:0006655)2.80727394
145response to pain (GO:0048265)2.80671759
146myeloid cell activation involved in immune response (GO:0002275)2.80228416
147peptidyl-threonine dephosphorylation (GO:0035970)2.80031135
148positive regulation of synaptic transmission, GABAergic (GO:0032230)2.79933985
149regulation of mast cell activation (GO:0033003)2.79924033
150replication fork processing (GO:0031297)2.78980769
151vitamin transmembrane transport (GO:0035461)2.78200999
152regulation of protein activation cascade (GO:2000257)2.77325705
153nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.75627622
154pentose-phosphate shunt (GO:0006098)2.75508761
155ribosomal small subunit biogenesis (GO:0042274)2.73873798
156negative regulation of interleukin-8 production (GO:0032717)2.73866885
157neuron cell-cell adhesion (GO:0007158)2.73807239
158DNA topological change (GO:0006265)2.73146254
159positive regulation of granulocyte chemotaxis (GO:0071624)2.73110402
160glutamate receptor signaling pathway (GO:0007215)2.72973527
161response to protozoan (GO:0001562)2.72923416
162lymphocyte migration (GO:0072676)2.72763928
163negative regulation of interleukin-12 production (GO:0032695)2.72508088
164protein localization to endoplasmic reticulum (GO:0070972)2.70676781
165hydrogen peroxide catabolic process (GO:0042744)2.70253804
166regulation of membrane depolarization (GO:0003254)2.65104974
167sodium ion homeostasis (GO:0055078)2.59910391
168collagen metabolic process (GO:0032963)2.57175663
169non-canonical Wnt signaling pathway (GO:0035567)2.56623494
170gamma-aminobutyric acid signaling pathway (GO:0007214)2.55133796
171negative regulation of cardiac muscle hypertrophy (GO:0010614)2.54178466
172multicellular organismal macromolecule metabolic process (GO:0044259)2.52541447
173protein localization to synapse (GO:0035418)2.51882405
174response to BMP (GO:0071772)2.51592651
175cellular response to BMP stimulus (GO:0071773)2.51592651
176bone development (GO:0060348)2.51492084
177glycosaminoglycan biosynthetic process (GO:0006024)2.50087647
178positive regulation of stress fiber assembly (GO:0051496)2.48831061
179negative regulation of leukocyte chemotaxis (GO:0002689)2.47541136
180collagen catabolic process (GO:0030574)2.46643571
181aminoglycan biosynthetic process (GO:0006023)2.46540431
182negative regulation of Ras protein signal transduction (GO:0046580)2.46228917
183regulation of Rho protein signal transduction (GO:0035023)2.45633762
184positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.45379027
185negative regulation of muscle hypertrophy (GO:0014741)2.43261172
186head development (GO:0060322)2.42750568
187membrane depolarization during action potential (GO:0086010)2.40721731
188neuronal action potential propagation (GO:0019227)2.39565090
189multicellular organismal metabolic process (GO:0044236)2.38947488
190regulation of short-term neuronal synaptic plasticity (GO:0048172)2.38941765
191positive regulation of gastrulation (GO:2000543)2.37737930
192negative regulation of small GTPase mediated signal transduction (GO:0051058)2.37647254
193regulation of focal adhesion assembly (GO:0051893)2.37299647
194regulation of cell-substrate junction assembly (GO:0090109)2.37299647
195retina layer formation (GO:0010842)2.36840835
196negative regulation of angiogenesis (GO:0016525)2.36425408
197synaptic transmission, glutamatergic (GO:0035249)2.34482281
198negative regulation of complement activation (GO:0045916)2.33109973
199negative regulation of cell-substrate adhesion (GO:0010812)2.32704755

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.48621688
2VDR_21846776_ChIP-Seq_THP-1_Human5.59295953
3EZH2_22144423_ChIP-Seq_EOC_Human5.36249319
4VDR_24763502_ChIP-Seq_THP-1_Human3.64304118
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.52296850
6MYC_22102868_ChIP-Seq_BL_Human3.35380405
7SCL_19346495_ChIP-Seq_HPC-7_Human3.02030959
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87706641
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76346297
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.74765168
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.72718410
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72579959
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72579959
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.70189300
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.63706355
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63693384
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49133476
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.47143882
19GBX2_23144817_ChIP-Seq_PC3_Human2.44945906
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36772469
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36554271
22GATA1_22025678_ChIP-Seq_K562_Human2.35314529
23SPI1_23547873_ChIP-Seq_NB4_Human2.29664963
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.23424466
25UTX_26944678_Chip-Seq_JUKART_Human2.23266712
26DROSHA_22980978_ChIP-Seq_HELA_Human2.22233553
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.20912512
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.20777352
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.16146220
30SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13158941
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.12145276
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.11697452
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08640225
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08443038
35MAF_26560356_Chip-Seq_TH1_Human2.07892144
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02804275
37IRF8_22096565_ChIP-ChIP_GC-B_Human2.00019032
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.97483942
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94226493
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.93852042
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.91047236
42KDM2B_26808549_Chip-Seq_DND41_Human1.88208200
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.87876138
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85236675
45MYC_18555785_ChIP-Seq_MESCs_Mouse1.85149789
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.84030115
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83994540
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.83960406
49TCF7_22412390_ChIP-Seq_EML_Mouse1.80808437
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.79909701
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79044319
52MAF_26560356_Chip-Seq_TH2_Human1.78137222
53MYB_26560356_Chip-Seq_TH2_Human1.77461157
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76828745
55MYB_26560356_Chip-Seq_TH1_Human1.76211023
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73312484
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72700059
58* LXR_22292898_ChIP-Seq_THP-1_Human1.71438020
59PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.71378838
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.71277957
61AR_21572438_ChIP-Seq_LNCaP_Human1.69203226
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65356967
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64387042
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61854790
65SPI1_23127762_ChIP-Seq_K562_Human1.60313969
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.58273756
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.57430495
68SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57159079
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52297182
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51557667
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49977109
72* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.47302541
73ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46845651
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46277449
75BP1_19119308_ChIP-ChIP_Hs578T_Human1.46247912
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.46176030
77P68_20966046_ChIP-Seq_HELA_Human1.45694274
78SMAD4_21799915_ChIP-Seq_A2780_Human1.45394715
79CIITA_25753668_ChIP-Seq_RAJI_Human1.44379595
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44277657
81FOXP3_21729870_ChIP-Seq_TREG_Human1.43519352
82MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42986676
83P300_19829295_ChIP-Seq_ESCs_Human1.42577654
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41097551
85REST_21632747_ChIP-Seq_MESCs_Mouse1.40802726
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40243631
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.39397117
88TP53_18474530_ChIP-ChIP_U2OS_Human1.39391257
89TAF15_26573619_Chip-Seq_HEK293_Human1.39148893
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38848522
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34581849
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33395100
93CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31891244
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31475918
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31411011
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30928757
97ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30725390
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30571016
99* PHF8_20622854_ChIP-Seq_HELA_Human1.29708672
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29216115
101BCL6_27268052_Chip-Seq_Bcells_Human1.29008760
102GATA1_19941827_ChIP-Seq_MEL_Mouse1.28914243
103ELF1_20517297_ChIP-Seq_JURKAT_Human1.28039245
104LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27370887
105SA1_27219007_Chip-Seq_ERYTHROID_Human1.27308774
106NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27100568
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26998889
108CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26856303
109PIAS1_25552417_ChIP-Seq_VCAP_Human1.26505503
110STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25957619
111KDM5A_27292631_Chip-Seq_BREAST_Human1.25624723
112BCOR_27268052_Chip-Seq_Bcells_Human1.25537740
113E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22568122
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21196634
115TP53_16413492_ChIP-PET_HCT116_Human1.21089500
116WT1_19549856_ChIP-ChIP_CCG9911_Human1.20475964
117SMAD3_21741376_ChIP-Seq_EPCs_Human1.20322046
118NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19094388
119PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18165969
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17094614
121ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16961368
122EGR1_19032775_ChIP-ChIP_M12_Human1.16193046
123VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15901927
124TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14916165
125ELK3_25401928_ChIP-Seq_HUVEC_Human1.14624220
126P300_27268052_Chip-Seq_Bcells_Human1.14459411
127SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11781198
128CTCF_21964334_ChIP-Seq_BJAB-B_Human1.11695274
129* E2F1_20622854_ChIP-Seq_HELA_Human1.11588862
130KDM2B_26808549_Chip-Seq_JURKAT_Human1.10848338
131ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10330534
132FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09909218
133NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09424538
134ETS1_20019798_ChIP-Seq_JURKAT_Human1.09198998
135THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09052324
136ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08804952
137MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08775814
138CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07030352
139IRF8_27001747_Chip-Seq_BMDM_Mouse1.06815240
140EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06378276
141UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06213832
142* CTCF_26484167_Chip-Seq_Bcells_Mouse1.06127742
143GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05978038
144DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05824966
145VDR_22108803_ChIP-Seq_LS180_Human1.05329220
146POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05294039
147CJUN_26792858_Chip-Seq_BT549_Human1.05225602
148RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05171676
149CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05004130
150XRN2_22483619_ChIP-Seq_HELA_Human1.04786764
151CTCF_21964334_Chip-Seq_Bcells_Human1.04773361
152ZNF274_21170338_ChIP-Seq_K562_Hela1.04439002
153SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04399252
154RUNX2_22187159_ChIP-Seq_PCA_Human1.03996884
155E2F1_21310950_ChIP-Seq_MCF-7_Human1.03601885
156TP53_20018659_ChIP-ChIP_R1E_Mouse1.03585886
157SOX2_21211035_ChIP-Seq_LN229_Gbm1.03489183
158POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03289916
159TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03289916
160PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03072070
161SMAD_19615063_ChIP-ChIP_OVARY_Human1.02411988
162NCOR1_26117541_ChIP-Seq_K562_Human1.01204980
163* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01136099
164KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00925764
165KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00925764
166KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00925764
167MYC_19079543_ChIP-ChIP_MESCs_Mouse1.00052434
168HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99648450
169BCAT_22108803_ChIP-Seq_LS180_Human0.99445699
170WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98835050
171AR_25329375_ChIP-Seq_VCAP_Human0.98733002
172CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98710950
173RING1B_27294783_Chip-Seq_NPCs_Mouse0.98418166
174* SPI1_20517297_ChIP-Seq_HL60_Human0.98073915
175YY1_21170310_ChIP-Seq_MESCs_Mouse0.97764574
176FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97166014
177RNF2_27304074_Chip-Seq_NSC_Mouse0.97154966
178AR_19668381_ChIP-Seq_PC3_Human0.97129259
179GABP_19822575_ChIP-Seq_HepG2_Human0.96001836
180ARNT_22903824_ChIP-Seq_MCF-7_Human0.95887810
181MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95402401
182ERG_21242973_ChIP-ChIP_JURKAT_Human0.95147300
183REST_18959480_ChIP-ChIP_MESCs_Mouse0.95008863
184STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.94995448
185NFE2_27457419_Chip-Seq_LIVER_Mouse0.94618304
186EP300_21415370_ChIP-Seq_HL-1_Mouse0.94528003
187EZH2_27294783_Chip-Seq_NPCs_Mouse0.93991708
188GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93653748
189TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93262391
190WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92920410
191SMAD4_21741376_ChIP-Seq_HESCs_Human0.92475334
192NANOG_18555785_Chip-Seq_ESCs_Mouse0.91345922
193EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90670729
194TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88777176
195RARB_27405468_Chip-Seq_BRAIN_Mouse0.88602060
196CTCF_27219007_Chip-Seq_Bcells_Human0.86420569
197TCF4_22108803_ChIP-Seq_LS180_Human0.86327289
198VDR_24787735_ChIP-Seq_THP-1_Human0.85986234
199SMAD3_21741376_ChIP-Seq_HESCs_Human0.83527065

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005257_abnormal_intraocular_pressure8.15127350
2MP0005503_abnormal_tendon_morphology7.45702265
3MP0002396_abnormal_hematopoietic_system5.34653322
4MP0008438_abnormal_cutaneous_collagen5.26599555
5MP0005275_abnormal_skin_tensile5.10591664
6MP0000751_myopathy3.55531143
7MP0003172_abnormal_lysosome_physiology3.25115176
8MP0001835_abnormal_antigen_presentation3.04352288
9MP0010094_abnormal_chromosome_stability3.00066903
10MP0004859_abnormal_synaptic_plasticity2.98256994
11MP0003436_decreased_susceptibility_to2.94159375
12MP0009278_abnormal_bone_marrow2.92146208
13MP0002108_abnormal_muscle_morphology2.87281014
14MP0002419_abnormal_innate_immunity2.70798556
15MP0005058_abnormal_lysosome_morphology2.53988714
16MP0003724_increased_susceptibility_to2.39245787
17MP0004185_abnormal_adipocyte_glucose2.37691469
18MP0005025_abnormal_response_to2.33186137
19MP0009379_abnormal_foot_pigmentation2.23593914
20MP0005397_hematopoietic_system_phenotyp2.20644580
21MP0001545_abnormal_hematopoietic_system2.20644580
22MP0004145_abnormal_muscle_electrophysio2.11995352
23MP0003635_abnormal_synaptic_transmissio2.10490311
24MP0005464_abnormal_platelet_physiology2.09377741
25MP0002420_abnormal_adaptive_immunity2.01699289
26MP0002009_preneoplasia2.00650548
27MP0001819_abnormal_immune_cell1.98831078
28MP0008057_abnormal_DNA_replication1.96869020
29MP0003763_abnormal_thymus_physiology1.94370674
30MP0002398_abnormal_bone_marrow1.93564138
31MP0002405_respiratory_system_inflammati1.88309419
32MP0004270_analgesia1.84119086
33MP0001800_abnormal_humoral_immune1.81194452
34MP0009745_abnormal_behavioral_response1.78285427
35MP0003111_abnormal_nucleus_morphology1.77777401
36MP0005000_abnormal_immune_tolerance1.77110936
37MP0003880_abnormal_central_pattern1.74976655
38MP0005508_abnormal_skeleton_morphology1.74235665
39MP0004272_abnormal_basement_membrane1.71026545
40MP0005174_abnormal_tail_pigmentation1.70266579
41MP0002723_abnormal_immune_serum1.70222786
42MP0000716_abnormal_immune_system1.68984176
43MP0005666_abnormal_adipose_tissue1.68470784
44MP0004130_abnormal_muscle_cell1.68282450
45MP0004808_abnormal_hematopoietic_stem1.66750257
46MP0002722_abnormal_immune_system1.62744833
47MP0002822_catalepsy1.61910549
48MP0002272_abnormal_nervous_system1.61734402
49MP0002452_abnormal_antigen_presenting1.61327165
50MP0001501_abnormal_sleep_pattern1.59009314
51MP0005671_abnormal_response_to1.58031255
52MP0000490_abnormal_crypts_of1.57908131
53MP0000747_muscle_weakness1.57750693
54MP0002064_seizures1.57483624
55MP0001486_abnormal_startle_reflex1.56645136
56MP0001958_emphysema1.56619714
57MP0009250_abnormal_appendicular_skeleto1.55928138
58MP0003656_abnormal_erythrocyte_physiolo1.55106572
59MP0002429_abnormal_blood_cell1.55026137
60MP0003300_gastrointestinal_ulcer1.54862093
61MP0000689_abnormal_spleen_morphology1.48313190
62MP0009780_abnormal_chondrocyte_physiolo1.47794765
63MP0000703_abnormal_thymus_morphology1.47738671
64MP0001968_abnormal_touch/_nociception1.47432055
65MP0008007_abnormal_cellular_replicative1.47163057
66MP0003303_peritoneal_inflammation1.36606423
67MP0002877_abnormal_melanocyte_morpholog1.34893933
68MP0003122_maternal_imprinting1.33987574
69MP0004381_abnormal_hair_follicle1.33060230
70MP0001790_abnormal_immune_system1.32118947
71MP0005387_immune_system_phenotype1.32118947
72MP0002063_abnormal_learning/memory/cond1.31835913
73MP0002249_abnormal_larynx_morphology1.31826244
74MP0004147_increased_porphyrin_level1.29246850
75MP0002060_abnormal_skin_morphology1.28721133
76MP0001346_abnormal_lacrimal_gland1.27836342
77MP0005623_abnormal_meninges_morphology1.25771977
78MP0002736_abnormal_nociception_after1.24273240
79MP0002572_abnormal_emotion/affect_behav1.24205401
80MP0001845_abnormal_inflammatory_respons1.23688959
81MP0002735_abnormal_chemical_nociception1.23483834
82MP0000685_abnormal_immune_system1.23149033
83MP0002734_abnormal_mechanical_nocicepti1.23145533
84MP0002295_abnormal_pulmonary_circulatio1.21607609
85MP0006054_spinal_hemorrhage1.21151371
86MP0002090_abnormal_vision1.20681632
87MP0005369_muscle_phenotype1.20004852
88MP0005075_abnormal_melanosome_morpholog1.18568124
89MP0005076_abnormal_cell_differentiation1.18102232
90MP0003866_abnormal_defecation1.17581204
91MP0002233_abnormal_nose_morphology1.15993869
92MP0002019_abnormal_tumor_incidence1.15363903
93MP0003693_abnormal_embryo_hatching1.15259045
94MP0002933_joint_inflammation1.14224892
95MP0000015_abnormal_ear_pigmentation1.14148471
96MP0001663_abnormal_digestive_system1.13853045
97MP0010155_abnormal_intestine_physiology1.12401888
98MP0009046_muscle_twitch1.10849989
99MP0002282_abnormal_trachea_morphology1.10619564
100MP0008995_early_reproductive_senescence1.10137711
101MP0002102_abnormal_ear_morphology1.08630128
102MP0003077_abnormal_cell_cycle1.08167083
103MP0003075_altered_response_to1.08120420
104MP0001853_heart_inflammation1.07774136
105MP0003786_premature_aging1.07447413
106MP0002166_altered_tumor_susceptibility1.07033938
107MP0005390_skeleton_phenotype1.06047597
108MP0005645_abnormal_hypothalamus_physiol1.05295200
109MP0009333_abnormal_splenocyte_physiolog1.05081010
110MP0005409_darkened_coat_color1.04240975
111MP0004510_myositis1.03912736
112MP0003045_fibrosis1.00709219
113MP0002148_abnormal_hypersensitivity_rea1.00679062
114MP0005451_abnormal_body_composition0.99715825
115MP0003828_pulmonary_edema0.98131451
116MP0000778_abnormal_nervous_system0.97992868
117MP0001970_abnormal_pain_threshold0.97823119
118MP0002184_abnormal_innervation0.97637541
119MP0001986_abnormal_taste_sensitivity0.97195625
120MP0004858_abnormal_nervous_system0.96978963
121MP0008469_abnormal_protein_level0.96405834
122MP0000759_abnormal_skeletal_muscle0.95234598
123MP0002067_abnormal_sensory_capabilities0.91546914
124MP0010307_abnormal_tumor_latency0.90896991
125MP0000462_abnormal_digestive_system0.89586057
126MP0000465_gastrointestinal_hemorrhage0.88870644
127MP0002075_abnormal_coat/hair_pigmentati0.88462249
128MP0004134_abnormal_chest_morphology0.87307309
129MP0000749_muscle_degeneration0.87101042
130MP0003221_abnormal_cardiomyocyte_apopto0.87071119
131MP0000163_abnormal_cartilage_morphology0.85822129
132MP0002733_abnormal_thermal_nociception0.84978842
133MP0002896_abnormal_bone_mineralization0.83475182
134MP0001873_stomach_inflammation0.82316663
135MP0005197_abnormal_uvea_morphology0.81936473
136MP0001440_abnormal_grooming_behavior0.80632187
137MP0000604_amyloidosis0.80586542
138MP0008961_abnormal_basal_metabolism0.79085870
139MP0005381_digestive/alimentary_phenotyp0.78916232
140MP0003279_aneurysm0.77790511
141MP0009785_altered_susceptibility_to0.76886639
142MP0001533_abnormal_skeleton_physiology0.76880811
143MP0004742_abnormal_vestibular_system0.75866210
144MP0006082_CNS_inflammation0.75849426
145MP0002837_dystrophic_cardiac_calcinosis0.74829570
146MP0000013_abnormal_adipose_tissue0.74764187
147MP0008873_increased_physiological_sensi0.74652936
148MP0003011_delayed_dark_adaptation0.74635313
149MP0001188_hyperpigmentation0.74552366
150MP0000750_abnormal_muscle_regeneration0.74099927
151MP0002095_abnormal_skin_pigmentation0.73983814
152MP0009672_abnormal_birth_weight0.73037221
153MP0002106_abnormal_muscle_physiology0.72592694
154MP0001177_atelectasis0.72582535
155MP0001299_abnormal_eye_distance/0.72525363
156MP0002006_tumorigenesis0.71035903
157MP0002115_abnormal_skeleton_extremities0.70953360
158MP0009763_increased_sensitivity_to0.69874869
159MP0001851_eye_inflammation0.69390324
160MP0000313_abnormal_cell_death0.69128386
161MP0001963_abnormal_hearing_physiology0.68927567
162MP0002133_abnormal_respiratory_system0.68679637
163MP0005388_respiratory_system_phenotype0.68679637
164MP0003690_abnormal_glial_cell0.68135473
165MP0005319_abnormal_enzyme/_coenzyme0.67475823
166MP0001727_abnormal_embryo_implantation0.67191210
167MP0002066_abnormal_motor_capabilities/c0.67160464
168MP0000534_abnormal_ureter_morphology0.67145092
169MP0005165_increased_susceptibility_to0.66207123
170MP0003646_muscle_fatigue0.65846624
171MP0004883_abnormal_blood_vessel0.65845933
172MP0003787_abnormal_imprinting0.64557399
173MP0003385_abnormal_body_wall0.64017488
174MP0001529_abnormal_vocalization0.63317069
175MP0005310_abnormal_salivary_gland0.63296653
176MP0005621_abnormal_cell_physiology0.62985609
177MP0009764_decreased_sensitivity_to0.62309079
178MP0000955_abnormal_spinal_cord0.59602790
179MP0000350_abnormal_cell_proliferation0.58797267
180MP0008058_abnormal_DNA_repair0.58766474
181MP0005164_abnormal_response_to0.57565003
182MP0008569_lethality_at_weaning0.57355705
183MP0008260_abnormal_autophagy0.56969959
184MP0004087_abnormal_muscle_fiber0.56323510
185MP0003633_abnormal_nervous_system0.55753262
186MP0003283_abnormal_digestive_organ0.55034754
187MP0001542_abnormal_bone_strength0.54514434
188MP0002557_abnormal_social/conspecific_i0.54336118
189MP0000733_abnormal_muscle_development0.53425934
190MP0003938_abnormal_ear_development0.53403100
191MP0000049_abnormal_middle_ear0.53121631
192MP0004133_heterotaxia0.51809422

Predicted human phenotypes

RankGene SetZ-score
1Flat cornea (HP:0007720)6.48155295
2Protrusio acetabuli (HP:0003179)6.02825559
3Ankle contracture (HP:0006466)5.27743022
4Type 1 muscle fiber predominance (HP:0003803)5.25652761
5Increased connective tissue (HP:0009025)4.81622048
6Muscle fiber splitting (HP:0003555)4.58050151
7Amyloidosis (HP:0011034)4.42368315
8Recurrent gram-negative bacterial infections (HP:0005420)4.40865215
9Focal motor seizures (HP:0011153)4.31589025
10Chronic obstructive pulmonary disease (HP:0006510)4.29795767
11Obstructive lung disease (HP:0006536)4.29795767
12Recurrent abscess formation (HP:0002722)4.26391696
13Slender build (HP:0001533)4.25119165
14Premature rupture of membranes (HP:0001788)4.25071455
15Follicular hyperkeratosis (HP:0007502)4.21059724
16Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.15397272
17Increased neuronal autofluorescent lipopigment (HP:0002074)4.14820836
18Complement deficiency (HP:0004431)4.11204505
19Broad metatarsal (HP:0001783)4.04097498
20Acute myeloid leukemia (HP:0004808)3.95286704
21Bronchomalacia (HP:0002780)3.94148127
22Recurrent bacterial skin infections (HP:0005406)3.90481513
23Acute lymphatic leukemia (HP:0006721)3.76659067
24Increased cerebral lipofuscin (HP:0011813)3.72873429
25Eczematoid dermatitis (HP:0000976)3.64000973
26Round ear (HP:0100830)3.61712821
27Spinal rigidity (HP:0003306)3.46439748
28Increased variability in muscle fiber diameter (HP:0003557)3.45468275
29Abnormality of the prostate (HP:0008775)3.43656723
30B lymphocytopenia (HP:0010976)3.37834385
31Abnormality of B cell number (HP:0010975)3.34494994
32Recurrent fungal infections (HP:0002841)3.31928697
33Thrombocytosis (HP:0001894)3.30816961
34Granulocytopenia (HP:0001913)3.28557732
35Panhypogammaglobulinemia (HP:0003139)3.25616283
36Soft skin (HP:0000977)3.21229823
37Chromosomal breakage induced by crosslinking agents (HP:0003221)3.17827230
38Reticulocytopenia (HP:0001896)3.15630572
39Striae distensae (HP:0001065)3.14690179
40Wrist flexion contracture (HP:0001239)3.08027981
41Abnormality of skeletal muscle fiber size (HP:0012084)3.02977931
42Chronic mucocutaneous candidiasis (HP:0002728)3.02218833
43Recurrent cutaneous fungal infections (HP:0011370)3.02218833
44Recurrent viral infections (HP:0004429)3.02039427
45Parakeratosis (HP:0001036)3.01489671
46Meningitis (HP:0001287)3.00677013
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.98305747
48Vacuolated lymphocytes (HP:0001922)2.96480982
49Mediastinal lymphadenopathy (HP:0100721)2.96405145
50Neonatal short-limb short stature (HP:0008921)2.93972093
51Dysmetric saccades (HP:0000641)2.93848063
52Abnormal number of erythroid precursors (HP:0012131)2.93220748
53Abnormality of complement system (HP:0005339)2.89595715
54Hypoventilation (HP:0002791)2.88792670
55Rectal prolapse (HP:0002035)2.85974916
56Encephalitis (HP:0002383)2.85590341
57Chromsome breakage (HP:0040012)2.83387151
58Shallow orbits (HP:0000586)2.83084748
59Mutism (HP:0002300)2.82259765
60Thoracic kyphosis (HP:0002942)2.81721322
61Stomatitis (HP:0010280)2.75923661
62Abnormality of cells of the erythroid lineage (HP:0012130)2.74360544
63Birth length less than 3rd percentile (HP:0003561)2.72311538
64Focal seizures (HP:0007359)2.67699307
65Mildly elevated creatine phosphokinase (HP:0008180)2.66937964
66Recurrent skin infections (HP:0001581)2.66057356
67Pallor (HP:0000980)2.65872087
68Pulmonary artery stenosis (HP:0004415)2.64349067
69Chest pain (HP:0100749)2.60859488
70Abnormal ciliary motility (HP:0012262)2.60747369
71Cellulitis (HP:0100658)2.60432022
72Abnormality of dentin (HP:0010299)2.59141708
73Atrophic scars (HP:0001075)2.58280348
74Limb hypertonia (HP:0002509)2.58138789
75Myokymia (HP:0002411)2.57523094
76Atonic seizures (HP:0010819)2.57001741
77Increased IgE level (HP:0003212)2.52910166
78Joint laxity (HP:0001388)2.48012938
79Myelodysplasia (HP:0002863)2.47830577
80Patent foramen ovale (HP:0001655)2.46590682
81Wormian bones (HP:0002645)2.45971519
8211 pairs of ribs (HP:0000878)2.43404947
83Respiratory difficulties (HP:0002880)2.42271566
84Partial agenesis of the corpus callosum (HP:0001338)2.40469609
85Annular pancreas (HP:0001734)2.38490025
86Abnormality of the thoracic spine (HP:0100711)2.36530510
87Cerebral aneurysm (HP:0004944)2.36486333
88Prolonged bleeding time (HP:0003010)2.35196097
89Epistaxis (HP:0000421)2.33509310
90Bell-shaped thorax (HP:0001591)2.32992844
91Fatigue (HP:0012378)2.32546148
92Mitral valve prolapse (HP:0001634)2.28629119
93Abnormality of macrophages (HP:0004311)2.28071921
94Muscle fiber inclusion bodies (HP:0100299)2.27713124
95Ureteral stenosis (HP:0000071)2.26134323
96Dilatation of the ascending aorta (HP:0005111)2.23648118
97Achilles tendon contracture (HP:0001771)2.21367332
98Concave nail (HP:0001598)2.21331585
99Spondylolisthesis (HP:0003302)2.20783068
100Bladder diverticulum (HP:0000015)2.20252015
101Abnormality of T cell physiology (HP:0011840)2.19592700
102Focal dystonia (HP:0004373)2.18557922
103Abnormality of male internal genitalia (HP:0000022)2.18518121
104Vertebral compression fractures (HP:0002953)2.18121683
105Pseudobulbar signs (HP:0002200)2.17700313
106Duplicated collecting system (HP:0000081)2.17131613
107Abnormal respiratory motile cilium physiology (HP:0012261)2.16256733
108Narrow nasal bridge (HP:0000446)2.16018216
109Torticollis (HP:0000473)2.15525089
110Thin bony cortex (HP:0002753)2.13538262
111Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.12402645
112Skin rash (HP:0000988)2.12018390
113Mesomelia (HP:0003027)2.11767183
114Hyperextensible skin (HP:0000974)2.10977969
115Urticaria (HP:0001025)2.07626666
116Abnormality of the fingertips (HP:0001211)2.07400624
117Gingivitis (HP:0000230)2.07274961
118Dynein arm defect of respiratory motile cilia (HP:0012255)2.05984141
119Absent/shortened dynein arms (HP:0200106)2.05984141
120Spontaneous hematomas (HP:0007420)2.05781171
121Hypoplasia of the iris (HP:0007676)2.05683041
122Broad-based gait (HP:0002136)2.04824118
123Abnormality of the Achilles tendon (HP:0005109)2.04525697
124Agammaglobulinemia (HP:0004432)2.04336088
125Limb-girdle muscle weakness (HP:0003325)2.04221519
126Abnormality of ocular smooth pursuit (HP:0000617)2.03819745
127Aortic dissection (HP:0002647)2.03292802
128Inflammation of the large intestine (HP:0002037)2.02719032
129Ureteral obstruction (HP:0006000)2.02615969
130Exercise-induced myalgia (HP:0003738)2.01447642
131Impaired smooth pursuit (HP:0007772)2.01000067
132Centrally nucleated skeletal muscle fibers (HP:0003687)2.00433923
133Gastrointestinal inflammation (HP:0004386)2.00207750
134Absence seizures (HP:0002121)2.00059962
135Diaphragmatic weakness (HP:0009113)1.99909342
136Lipid accumulation in hepatocytes (HP:0006561)1.99600025
137Wide anterior fontanel (HP:0000260)1.99506864
138Genu recurvatum (HP:0002816)1.99483666
139Hemoptysis (HP:0002105)1.99009872
140Generalized tonic-clonic seizures (HP:0002069)1.98831306
141Osteomyelitis (HP:0002754)1.98422213
142Biconcave vertebral bodies (HP:0004586)1.97385718
143Pustule (HP:0200039)1.96210619
144Mild short stature (HP:0003502)1.96105675
145Dialeptic seizures (HP:0011146)1.95753327
146Myositis (HP:0100614)1.95744625
147Obstructive sleep apnea (HP:0002870)1.94880541
148Craniofacial dystonia (HP:0012179)1.94367621
149Upper motor neuron abnormality (HP:0002127)1.94095519
150Chin dimple (HP:0010751)1.94003500
151Fragile skin (HP:0001030)1.93746500
152Limited hip movement (HP:0008800)1.93518225
153Corneal dystrophy (HP:0001131)1.92329540
154Increased muscle lipid content (HP:0009058)1.91772689
155Submucous cleft hard palate (HP:0000176)1.88013179
156Bone marrow hypocellularity (HP:0005528)1.87643307
157Abnormal platelet function (HP:0011869)1.87361396
158Impaired platelet aggregation (HP:0003540)1.87361396
159Abnormality of the calf musculature (HP:0001430)1.86946589
160Tachypnea (HP:0002789)1.85971063
161Progressive muscle weakness (HP:0003323)1.84857210
162Abnormality of the preputium (HP:0100587)1.83116350
163Venous insufficiency (HP:0005293)1.82179029
164Visual hallucinations (HP:0002367)1.81900996
165Coronal craniosynostosis (HP:0004440)1.81581440
166Increased hepatocellular lipid droplets (HP:0006565)1.81522792
167Nemaline bodies (HP:0003798)1.81405494
168Hypergonadotropic hypogonadism (HP:0000815)1.81193815
169Limb ataxia (HP:0002070)1.80852710
170Onion bulb formation (HP:0003383)1.80383082
171Aplasia/Hypoplasia of the uvula (HP:0010293)1.79933769
172Impulsivity (HP:0100710)1.79616960
173Increased intramyocellular lipid droplets (HP:0012240)1.79568009
174Hypoplastic ischia (HP:0003175)1.79351779
175Abnormality of chromosome stability (HP:0003220)1.78956791
176Teleangiectasia of the skin (HP:0100585)1.77729113
177Clubbing of toes (HP:0100760)1.76309840
178Colitis (HP:0002583)1.75891368
179Venous abnormality (HP:0002624)1.75714141
180Abnormal delivery (HP:0001787)1.75206937
181Pulmonary embolism (HP:0002204)1.74928595
182Elevated erythrocyte sedimentation rate (HP:0003565)1.74400292
183Abnormal respiratory motile cilium morphology (HP:0005938)1.74130410
184Abnormal respiratory epithelium morphology (HP:0012253)1.74130410
185Synostosis involving the elbow (HP:0003938)1.73668165
186Humeroradial synostosis (HP:0003041)1.73668165
187Bulbar palsy (HP:0001283)1.72806154
188Protruding ear (HP:0000411)1.71583088
189Turricephaly (HP:0000262)1.71182069
190Tracheomalacia (HP:0002779)1.70935660
191Rhinitis (HP:0012384)1.70540675
192Febrile seizures (HP:0002373)1.69355465
193Prominent supraorbital ridges (HP:0000336)1.69011875
194Action tremor (HP:0002345)1.67596937
195Abnormality of the renal collecting system (HP:0004742)1.64489972
196EMG: myopathic abnormalities (HP:0003458)1.64397119
197Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.63135812

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.70226415
2MAPK154.02324535
3MAP2K33.58832998
4MAP4K13.49712362
5TRIB33.28625392
6CDK123.15717851
7TSSK62.68230902
8DDR22.60947672
9EEF2K2.54812806
10PNCK2.51306993
11TLK12.48223607
12MAP3K132.40341538
13PIK3CG2.27201076
14SIK22.23608704
15KIT2.17811921
16ERN12.13438196
17RIPK12.11191590
18LATS22.00502513
19TEC1.90451741
20CASK1.88179824
21RPS6KA41.85825786
22ICK1.85031080
23TNK21.82894302
24BTK1.81000486
25CAMK1G1.79680738
26CDC71.78535208
27OBSCN1.76556569
28MARK11.75134213
29MAP3K111.71168311
30IRAK41.69815252
31TESK21.68650564
32IRAK31.60956975
33GRK61.57655043
34CSK1.53879207
35LATS11.52704358
36CDK41.51658423
37NEK61.51576572
38CAMK1D1.51548519
39TYK21.50734726
40NTRK21.47652777
41PASK1.43036910
42SIK11.39530964
43SYK1.39237237
44CDK61.37038180
45EPHB11.36084904
46DMPK1.35868797
47PIK3CA1.30446552
48MAP3K91.28498708
49PAK61.26515231
50PRKCH1.26069527
51PHKG11.24409267
52PHKG21.24409267
53MAPK131.23901462
54BLK1.21885202
55MAP2K41.21861393
56TAOK11.21401566
57ATR1.21314212
58PKN21.20735143
59DAPK21.20734968
60MAP3K21.20358225
61ZAP701.19612182
62MAP3K71.18266213
63SMG11.10128658
64CSF1R1.09643838
65TTN1.09125988
66NME11.08337738
67PTK2B1.08031073
68LYN1.06954396
69ITK1.06882898
70RET1.03861314
71BRD41.03089304
72HCK1.02849318
73NME21.02068543
74PKN11.00285864
75GRK50.96975799
76PAK20.96812981
77MAP3K140.96170301
78EPHA40.95435620
79CAMKK10.95180219
80PDGFRA0.94658083
81NEK20.94503294
82MAP3K40.94162612
83MAP3K10.91933512
84BMPR1B0.91361435
85MAP2K20.91212100
86CDK50.89557826
87HIPK20.89075760
88STK390.88009144
89PDPK10.87441114
90CDK190.87335802
91PIM20.86341619
92PRKCG0.84317161
93RPS6KA60.82495548
94LCK0.80675058
95CAMK2A0.80398699
96MAPKAPK50.79440133
97ABL20.79143367
98SIK30.78464433
99EPHA30.78403976
100RPS6KB20.76884578
101CAMK2B0.76385424
102ADRBK20.76225802
103MAP2K10.75797922
104EPHB20.75562428
105MAP2K60.75279965
106RIPK40.74857517
107PLK40.74690311
108PDK10.73651960
109MAP2K70.73219627
110MAPK120.72638512
111ROCK20.71757905
112STK110.71656775
113MINK10.71194940
114UHMK10.71185395
115RPS6KC10.70759505
116RPS6KL10.70759505
117CAMK10.68386766
118CDK70.67046025
119FGFR20.66902107
120CLK10.66727952
121FES0.64932589
122MATK0.64013604
123TRPM70.63953083
124AKT30.63350152
125IRAK20.61672481
126PRKCE0.61518272
127CHEK20.59827370
128TAOK30.59436851
129KSR10.59231631
130WNK10.58378169
131JAK20.58246489
132PRKAA20.57514993
133OXSR10.56872009
134NTRK10.56813932
135PRPF4B0.56545716
136MAP3K80.56073648
137PDGFRB0.55916287
138GSK3A0.55014305
139PAK30.52866382
140MARK20.52265734
141JAK10.52064651
142MST1R0.51888660
143MAP3K60.51515548
144MAP3K50.50949937
145CDC42BPA0.50811834
146PAK40.50661740
147PIM10.50125169
148MAPK40.49798166
149MTOR0.49375631
150PRKCQ0.48806533
151BMX0.47909357
152ALK0.47212251
153LRRK20.45124634
154PRKACA0.45093568
155CHEK10.44909332
156RPS6KA20.44343474
157CAMK40.44266384
158CSNK1E0.44179402
159RPS6KA50.43152473
160SGK2230.42458056
161SGK4940.42458056
162PRKD10.42154883
163SGK10.42076369
164TGFBR20.41832316
165ERBB40.41132555
166MAPK100.40780593
167JAK30.40337320
168RPS6KA30.40161353
169MAPK30.40133505
170CDK20.38043293
171KSR20.37564515
172TAOK20.35389856
173MAPK110.35133795
174TXK0.35079633
175RAF10.34829409
176GRK10.33507290
177PRKD20.33372367
178MAP3K30.30946565

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.67463310
2Nicotine addiction_Homo sapiens_hsa050333.54581685
3ECM-receptor interaction_Homo sapiens_hsa045123.28084336
4Asthma_Homo sapiens_hsa053103.12722428
5Acute myeloid leukemia_Homo sapiens_hsa052212.93444331
6Ribosome_Homo sapiens_hsa030102.57557857
7Malaria_Homo sapiens_hsa051442.50805551
8B cell receptor signaling pathway_Homo sapiens_hsa046622.45184831
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.34562584
10Leishmaniasis_Homo sapiens_hsa051402.20859958
11Base excision repair_Homo sapiens_hsa034102.20015326
12Other glycan degradation_Homo sapiens_hsa005112.14925099
13GABAergic synapse_Homo sapiens_hsa047272.10447091
14Prion diseases_Homo sapiens_hsa050202.10057713
15Homologous recombination_Homo sapiens_hsa034402.00574996
16Non-homologous end-joining_Homo sapiens_hsa034501.99682954
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.97543806
18Circadian entrainment_Homo sapiens_hsa047131.90339546
19Dilated cardiomyopathy_Homo sapiens_hsa054141.87705724
20Fanconi anemia pathway_Homo sapiens_hsa034601.84383641
21Protein digestion and absorption_Homo sapiens_hsa049741.82400426
22Morphine addiction_Homo sapiens_hsa050321.80774295
23Non-small cell lung cancer_Homo sapiens_hsa052231.80657163
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78162263
25Amphetamine addiction_Homo sapiens_hsa050311.77038055
26Pancreatic cancer_Homo sapiens_hsa052121.74712899
27Glutamatergic synapse_Homo sapiens_hsa047241.73443767
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.71803503
29Salivary secretion_Homo sapiens_hsa049701.68947384
30Calcium signaling pathway_Homo sapiens_hsa040201.66260031
31Taste transduction_Homo sapiens_hsa047421.60970983
32Chronic myeloid leukemia_Homo sapiens_hsa052201.57572045
33Cardiac muscle contraction_Homo sapiens_hsa042601.57118029
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.56495785
35Cocaine addiction_Homo sapiens_hsa050301.55747192
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.53527003
37Type II diabetes mellitus_Homo sapiens_hsa049301.50980347
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.49998392
39Oxytocin signaling pathway_Homo sapiens_hsa049211.49379793
40Focal adhesion_Homo sapiens_hsa045101.48792220
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45680461
42Long-term potentiation_Homo sapiens_hsa047201.43696094
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41939374
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41047655
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40312303
46Prolactin signaling pathway_Homo sapiens_hsa049171.39724778
47Renin secretion_Homo sapiens_hsa049241.39513665
48Estrogen signaling pathway_Homo sapiens_hsa049151.36665476
49Olfactory transduction_Homo sapiens_hsa047401.36029017
50Axon guidance_Homo sapiens_hsa043601.35684302
51Serotonergic synapse_Homo sapiens_hsa047261.35124075
52Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29392486
53Gastric acid secretion_Homo sapiens_hsa049711.26648852
54Insulin secretion_Homo sapiens_hsa049111.26597208
55Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25594399
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24897071
57Synaptic vesicle cycle_Homo sapiens_hsa047211.23636985
58Complement and coagulation cascades_Homo sapiens_hsa046101.23519790
59Systemic lupus erythematosus_Homo sapiens_hsa053221.22943760
60Dopaminergic synapse_Homo sapiens_hsa047281.22208269
61Vitamin digestion and absorption_Homo sapiens_hsa049771.21948908
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20986481
63Tuberculosis_Homo sapiens_hsa051521.17998529
64Glycerophospholipid metabolism_Homo sapiens_hsa005641.17505816
65T cell receptor signaling pathway_Homo sapiens_hsa046601.16767844
66Long-term depression_Homo sapiens_hsa047301.15606044
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.13561768
68Hepatitis B_Homo sapiens_hsa051611.13291607
69Phagosome_Homo sapiens_hsa041451.10751910
70MAPK signaling pathway_Homo sapiens_hsa040101.07670373
71Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07341842
72cAMP signaling pathway_Homo sapiens_hsa040241.06662404
73Primary immunodeficiency_Homo sapiens_hsa053401.05688999
74Cholinergic synapse_Homo sapiens_hsa047251.05543062
75Sulfur relay system_Homo sapiens_hsa041221.04281385
76GnRH signaling pathway_Homo sapiens_hsa049121.03824902
77Sphingolipid signaling pathway_Homo sapiens_hsa040711.02321308
78Vascular smooth muscle contraction_Homo sapiens_hsa042701.01686301
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01531028
80cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01132984
81Amoebiasis_Homo sapiens_hsa051461.00227917
82Gap junction_Homo sapiens_hsa045400.97698035
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.97689488
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97597982
85Dorso-ventral axis formation_Homo sapiens_hsa043200.96426478
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96306531
87Hematopoietic cell lineage_Homo sapiens_hsa046400.94047571
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93610551
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92061902
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87216395
91Viral carcinogenesis_Homo sapiens_hsa052030.86840831
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85711754
93Nucleotide excision repair_Homo sapiens_hsa034200.85558239
94Staphylococcus aureus infection_Homo sapiens_hsa051500.84634051
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83960129
96Alcoholism_Homo sapiens_hsa050340.83801503
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83257483
98Spliceosome_Homo sapiens_hsa030400.83124645
99mTOR signaling pathway_Homo sapiens_hsa041500.82128931
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.81173377
101Herpes simplex infection_Homo sapiens_hsa051680.81104646
102Influenza A_Homo sapiens_hsa051640.80752103
103ErbB signaling pathway_Homo sapiens_hsa040120.80175668
104Toxoplasmosis_Homo sapiens_hsa051450.80014324
105Colorectal cancer_Homo sapiens_hsa052100.79580414
106Bladder cancer_Homo sapiens_hsa052190.79478251
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.79098678
108Melanogenesis_Homo sapiens_hsa049160.78408744
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78278973
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77096201
111TNF signaling pathway_Homo sapiens_hsa046680.76530289
112Alzheimers disease_Homo sapiens_hsa050100.75270593
113Inositol phosphate metabolism_Homo sapiens_hsa005620.74851715
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74332828
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72682588
116Pentose phosphate pathway_Homo sapiens_hsa000300.70697213
117African trypanosomiasis_Homo sapiens_hsa051430.70338932
118Chemokine signaling pathway_Homo sapiens_hsa040620.70162726
119Rheumatoid arthritis_Homo sapiens_hsa053230.67467640
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67330721
121Measles_Homo sapiens_hsa051620.66140566
122Collecting duct acid secretion_Homo sapiens_hsa049660.65765057
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64944844
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.64060428
125Hepatitis C_Homo sapiens_hsa051600.63053090
126Epstein-Barr virus infection_Homo sapiens_hsa051690.62176307
127Wnt signaling pathway_Homo sapiens_hsa043100.61882455
128Cell cycle_Homo sapiens_hsa041100.61792713
129Fatty acid biosynthesis_Homo sapiens_hsa000610.61157835
130HTLV-I infection_Homo sapiens_hsa051660.60844949
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.60370082
132Antigen processing and presentation_Homo sapiens_hsa046120.60111172
133Glucagon signaling pathway_Homo sapiens_hsa049220.59725435
134Phototransduction_Homo sapiens_hsa047440.59616585
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57942773
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.57812178
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57340913
138Glioma_Homo sapiens_hsa052140.56487114
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55852825
140Choline metabolism in cancer_Homo sapiens_hsa052310.55562067
141Pyrimidine metabolism_Homo sapiens_hsa002400.55555136
142Ras signaling pathway_Homo sapiens_hsa040140.55412905
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55410173
144Oxidative phosphorylation_Homo sapiens_hsa001900.54677593
145Pancreatic secretion_Homo sapiens_hsa049720.53999514
146TGF-beta signaling pathway_Homo sapiens_hsa043500.51707914
147Renal cell carcinoma_Homo sapiens_hsa052110.51482268
148Hedgehog signaling pathway_Homo sapiens_hsa043400.51043600
149Insulin resistance_Homo sapiens_hsa049310.50033992
150Endometrial cancer_Homo sapiens_hsa052130.49577767
151Ether lipid metabolism_Homo sapiens_hsa005650.47982383
152Pertussis_Homo sapiens_hsa051330.46170371
153Graft-versus-host disease_Homo sapiens_hsa053320.45811204
154Phospholipase D signaling pathway_Homo sapiens_hsa040720.45568195
155Lysosome_Homo sapiens_hsa041420.44696725
156Legionellosis_Homo sapiens_hsa051340.44279488
157NF-kappa B signaling pathway_Homo sapiens_hsa040640.43444587
158Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43404390
159Mismatch repair_Homo sapiens_hsa034300.41782655
160Osteoclast differentiation_Homo sapiens_hsa043800.41620630
161Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40280924
162Ovarian steroidogenesis_Homo sapiens_hsa049130.40017458
163Insulin signaling pathway_Homo sapiens_hsa049100.39892971
164Vibrio cholerae infection_Homo sapiens_hsa051100.39213821
165Apoptosis_Homo sapiens_hsa042100.38470136
166Platelet activation_Homo sapiens_hsa046110.38064039
167Thyroid hormone synthesis_Homo sapiens_hsa049180.37844880
168Prostate cancer_Homo sapiens_hsa052150.36520769
169SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35485118
170Adipocytokine signaling pathway_Homo sapiens_hsa049200.34904459
171Circadian rhythm_Homo sapiens_hsa047100.34052029
172VEGF signaling pathway_Homo sapiens_hsa043700.33594217
173Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33180064
174Bile secretion_Homo sapiens_hsa049760.33156752
175Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32770016
176Huntingtons disease_Homo sapiens_hsa050160.32685245
177Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32529228
178Melanoma_Homo sapiens_hsa052180.32509298

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