PTRF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)5.72731961
2collagen fibril organization (GO:0030199)4.96983748
3chondrocyte proliferation (GO:0035988)4.54673195
4barbed-end actin filament capping (GO:0051016)4.42247798
5retina vasculature morphogenesis in camera-type eye (GO:0061299)4.39766452
6regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.37492561
7vascular endothelial growth factor signaling pathway (GO:0038084)4.27071689
8plasma membrane repair (GO:0001778)4.15435802
9basement membrane organization (GO:0071711)4.07583710
10low-density lipoprotein particle clearance (GO:0034383)4.05971687
11kidney mesenchyme development (GO:0072074)3.98901996
12type B pancreatic cell proliferation (GO:0044342)3.89597713
13endodermal cell differentiation (GO:0035987)3.87663093
14COPI coating of Golgi vesicle (GO:0048205)3.87635368
15Golgi transport vesicle coating (GO:0048200)3.87635368
16sequestering of extracellular ligand from receptor (GO:0035581)3.84272465
17positive regulation of endothelial cell apoptotic process (GO:2000353)3.78863989
18regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.75706360
19hemidesmosome assembly (GO:0031581)3.72813958
20protein localization to endosome (GO:0036010)3.66291673
21substrate-dependent cell migration (GO:0006929)3.66275259
22regulation of tight junction assembly (GO:2000810)3.65716903
23wound healing, spreading of epidermal cells (GO:0035313)3.65460422
24cell adhesion mediated by integrin (GO:0033627)3.64801269
25endothelial cell morphogenesis (GO:0001886)3.60094277
26renal filtration (GO:0097205)3.55494016
27axon extension involved in axon guidance (GO:0048846)3.53830727
28neuron projection extension involved in neuron projection guidance (GO:1902284)3.53830727
29cell-substrate adherens junction assembly (GO:0007045)3.52231712
30focal adhesion assembly (GO:0048041)3.52231712
31epithelial cell-cell adhesion (GO:0090136)3.51577155
32collagen metabolic process (GO:0032963)3.50870278
33cardiac myofibril assembly (GO:0055003)3.45013725
34sarcomere organization (GO:0045214)3.43819942
35skin morphogenesis (GO:0043589)3.43638449
36negative regulation of fatty acid transport (GO:2000192)3.42853196
37apoptotic cell clearance (GO:0043277)3.42493513
38muscle filament sliding (GO:0030049)3.42434355
39actin-myosin filament sliding (GO:0033275)3.42434355
40glomerular filtration (GO:0003094)3.37949058
41glomerular basement membrane development (GO:0032836)3.35272627
42multicellular organismal macromolecule metabolic process (GO:0044259)3.34247589
43collagen catabolic process (GO:0030574)3.33795910
44cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.33526969
45heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.33400531
46metanephric mesenchyme development (GO:0072075)3.29892767
47cell-substrate junction assembly (GO:0007044)3.26779558
48membrane raft organization (GO:0031579)3.24874894
49fibroblast migration (GO:0010761)3.24109329
50protein retention in ER lumen (GO:0006621)3.20277559
51actin-mediated cell contraction (GO:0070252)3.19879393
52multicellular organismal metabolic process (GO:0044236)3.18797422
53maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.16544755
54regulation of integrin-mediated signaling pathway (GO:2001044)3.13785420
55stress fiber assembly (GO:0043149)3.13016886
56negative regulation of nitric-oxide synthase activity (GO:0051001)3.11973773
57lymph vessel development (GO:0001945)3.11573430
58lymphangiogenesis (GO:0001946)3.10678088
59multicellular organismal catabolic process (GO:0044243)3.08030505
60planar cell polarity pathway involved in neural tube closure (GO:0090179)3.07559941
61extracellular fibril organization (GO:0043206)3.07333490
62extracellular matrix disassembly (GO:0022617)3.06396490
63atrioventricular valve morphogenesis (GO:0003181)3.06229316
64cell migration involved in sprouting angiogenesis (GO:0002042)3.05967436
65heart trabecula formation (GO:0060347)3.03868742
66sprouting angiogenesis (GO:0002040)3.02495868
67dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.02218055
68virion attachment to host cell (GO:0019062)3.00888782
69adhesion of symbiont to host cell (GO:0044650)3.00888782
70hypotonic response (GO:0006971)2.99678822
71positive regulation of epithelial to mesenchymal transition (GO:0010718)2.97321981
72ovulation from ovarian follicle (GO:0001542)2.96730829
73protein localization to cell surface (GO:0034394)2.96520337
74regulation of plasminogen activation (GO:0010755)2.94709170
75venous blood vessel morphogenesis (GO:0048845)2.93979848
76cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.93221689
77fibril organization (GO:0097435)2.92747488
78actin filament depolymerization (GO:0030042)2.91929424
79phagocytosis, recognition (GO:0006910)2.90250466
80hippo signaling (GO:0035329)2.89841175
81bone trabecula formation (GO:0060346)2.89304505
82wound healing, spreading of cells (GO:0044319)2.88992739
83trabecula formation (GO:0060343)2.87839434
84substrate adhesion-dependent cell spreading (GO:0034446)2.86581313
85blood vessel maturation (GO:0001955)2.85751404
86hyaluronan catabolic process (GO:0030214)2.85341329
87actomyosin structure organization (GO:0031032)2.84803568
88dermatan sulfate biosynthetic process (GO:0030208)2.84739782
89muscle cell migration (GO:0014812)2.84556393
90blood vessel endothelial cell migration (GO:0043534)2.84496008
91regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.84265299
92positive regulation of blood vessel endothelial cell migration (GO:0043536)2.84236187
93negative regulation of chondrocyte differentiation (GO:0032331)2.84047475
94positive regulation of receptor recycling (GO:0001921)2.79415316
95positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.79283046
96cellular response to vitamin (GO:0071295)2.79230598
97endocardial cushion development (GO:0003197)2.78860292
98myofibril assembly (GO:0030239)2.78030083
99positive regulation of osteoblast proliferation (GO:0033690)2.77625822
100regulation of skeletal muscle contraction (GO:0014819)2.75416101
101insulin-like growth factor receptor signaling pathway (GO:0048009)2.75270743
102positive regulation of fibroblast migration (GO:0010763)2.75146299
103protein targeting to plasma membrane (GO:0072661)2.74811622
104vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.73921695
105peptidyl-proline hydroxylation (GO:0019511)2.73286167
106pericardium development (GO:0060039)2.72421866
107cell migration involved in heart development (GO:0060973)2.72187075
108cellular response to vitamin D (GO:0071305)2.72119634
109adherens junction assembly (GO:0034333)2.71679742
110negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.71548610
111white fat cell differentiation (GO:0050872)2.71295093
112negative regulation of cartilage development (GO:0061037)2.71159029
113positive regulation of endothelial cell migration (GO:0010595)2.69487094
114negative regulation of smooth muscle cell migration (GO:0014912)2.68779321
115positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.68567323
116protein hydroxylation (GO:0018126)2.68389565
117extracellular matrix assembly (GO:0085029)2.68069194
118adhesion of symbiont to host (GO:0044406)2.63870598
119actin filament-based movement (GO:0030048)2.63438283
120keratan sulfate catabolic process (GO:0042340)2.61594356
121extracellular matrix organization (GO:0030198)2.61534151
122regulation of early endosome to late endosome transport (GO:2000641)2.60710857
123endothelial cell proliferation (GO:0001935)2.60484470
124extracellular structure organization (GO:0043062)2.60396029
125paraxial mesoderm development (GO:0048339)2.60337654
126endocytic recycling (GO:0032456)2.58701618
127regulation of sequestering of triglyceride (GO:0010889)2.57005976
128negative regulation of BMP signaling pathway (GO:0030514)2.56951537
129mesenchymal-epithelial cell signaling (GO:0060638)2.56789876
130response to fluid shear stress (GO:0034405)2.56252970
131dermatan sulfate metabolic process (GO:0030205)2.54786148
132cardiac muscle cell proliferation (GO:0060038)2.52822956
133mesodermal cell differentiation (GO:0048333)2.51236773
134desmosome organization (GO:0002934)2.50694940
135ventricular cardiac muscle cell development (GO:0055015)2.50596823
136positive regulation of glycogen biosynthetic process (GO:0045725)2.50458660

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.43478027
2TRIM28_21343339_ChIP-Seq_HEK293_Human6.08412610
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.17287159
4RARG_19884340_ChIP-ChIP_MEFs_Mouse5.01550293
5CLOCK_20551151_ChIP-Seq_293T_Human4.10591933
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.21120315
7* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.93666327
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.88160797
9* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.83085548
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.75431790
11* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.69857867
12EP300_21415370_ChIP-Seq_HL-1_Mouse2.60457354
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.56448735
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.53304951
15CJUN_26792858_Chip-Seq_BT549_Human2.48736213
16CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.43584835
17ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.19764786
18GATA2_21666600_ChIP-Seq_HMVEC_Human2.19305354
19CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.18976208
20* ELK3_25401928_ChIP-Seq_HUVEC_Human2.07064286
21* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.05251871
22ESR1_21235772_ChIP-Seq_MCF-7_Human2.05000423
23PPAR_26484153_Chip-Seq_NCI-H1993_Human2.04298244
24SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.99492275
25SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.99492275
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.92840440
27* BRD4_25478319_ChIP-Seq_HGPS_Human1.89701610
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.88885427
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.85548614
30ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.80902514
31TBX20_22080862_ChIP-Seq_HEART_Mouse1.79327785
32TBX20_22328084_ChIP-Seq_HEART_Mouse1.79327785
33ESR1_20079471_ChIP-ChIP_T-47D_Human1.76203488
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68225761
35* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61915804
36SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.60994030
37* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58236529
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.54290997
39NRF2_20460467_ChIP-Seq_MEFs_Mouse1.54290997
40MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.52366225
41* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.52026338
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.51760561
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.51239021
44SALL4_18804426_ChIP-ChIP_XEN_Mouse1.51127394
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48648524
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.47922129
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.47373443
48ATF3_27146783_Chip-Seq_COLON_Human1.47065071
49* LXR_22292898_ChIP-Seq_THP-1_Human1.46030961
50* SOX2_20726797_ChIP-Seq_SW620_Human1.44878534
51* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43291378
52UBF1/2_26484160_Chip-Seq_HMECs_Human1.42489665
53SMC1_22415368_ChIP-Seq_MEFs_Mouse1.39570733
54NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.38052661
55P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36752120
56RACK7_27058665_Chip-Seq_MCF-7_Human1.32676789
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32361696
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.30744126
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30608123
60TP53_18474530_ChIP-ChIP_U2OS_Human1.26563257
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25944416
62P63_26484246_Chip-Seq_KERATINOCYTES_Human1.23500160
63* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.21570030
64TP53_22127205_ChIP-Seq_IMR90_Human1.19050667
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18971584
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18590673
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18053816
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17826935
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15003932
70* EED_16625203_ChIP-ChIP_MESCs_Mouse1.14612558
71ZNF263_19887448_ChIP-Seq_K562_Human1.13735876
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.12736572
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10497380
74DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10047563
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09794515
76* TET1_21490601_ChIP-Seq_MESCs_Mouse1.09496719
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08720886
78FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07510838
79* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07150960
80TP53_23651856_ChIP-Seq_MEFs_Mouse1.05875894
81TP53_16413492_ChIP-PET_HCT116_Human1.04352173
82GATA1_22025678_ChIP-Seq_K562_Human1.04006415
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03772465
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02339020
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01245735
86* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.00858262
87* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.00858262
88GATA4_21415370_ChIP-Seq_HL-1_Mouse1.00757462
89* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00382385
90STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00044699
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97311759
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97275720
93FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96641985
94SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96537925
95* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96497051
96ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94107353
97ISL1_27105846_Chip-Seq_CPCs_Mouse0.93000826
98KLF5_25053715_ChIP-Seq_YYC3_Human0.92835376
99* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92121289
100* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90929382
101AR_21909140_ChIP-Seq_LNCAP_Human0.90342084
102KDM2B_26808549_Chip-Seq_JURKAT_Human0.88622020
103RUNX1_27514584_Chip-Seq_MCF-7_Human0.88324028
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88220474
105ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87870838
106TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87783755
107NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86298319
108ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85122432
109ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85094787
110TCF4_18268006_ChIP-ChIP_LS174T_Human0.84859890
111CDX2_20551321_ChIP-Seq_CACO-2_Human0.82526122
112GATA3_24758297_ChIP-Seq_MCF-7_Human0.82015382
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80500809
114* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80467247
115NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80299729
116SA1_22415368_ChIP-Seq_MEFs_Mouse0.80091117
117KDM2B_26808549_Chip-Seq_K562_Human0.79954814
118ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.79471038
119TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.78772058
120EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.78311631

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.46801593
2MP0005275_abnormal_skin_tensile4.42829298
3MP0003705_abnormal_hypodermis_morpholog4.08117652
4MP0005503_abnormal_tendon_morphology3.64761899
5MP0003279_aneurysm3.41641815
6MP0004272_abnormal_basement_membrane3.34217684
7MP0001958_emphysema2.73352860
8MP0010368_abnormal_lymphatic_system2.71281666
9MP0003566_abnormal_cell_adhesion2.41076722
10MP0005623_abnormal_meninges_morphology2.35304926
11MP0005670_abnormal_white_adipose2.20637075
12MP0004084_abnormal_cardiac_muscle2.14763405
13MP0009384_cardiac_valve_regurgitation2.09681783
14MP0001879_abnormal_lymphatic_vessel2.07876845
15MP0000751_myopathy2.05426987
16MP0006054_spinal_hemorrhage1.95671867
17MP0000013_abnormal_adipose_tissue1.92969310
18MP0000750_abnormal_muscle_regeneration1.91719358
19MP0003091_abnormal_cell_migration1.84972877
20MP0002060_abnormal_skin_morphology1.81955818
21MP0000749_muscle_degeneration1.81862334
22MP0003828_pulmonary_edema1.73821301
23MP0002837_dystrophic_cardiac_calcinosis1.72560760
24MP0005023_abnormal_wound_healing1.69177125
25MP0010030_abnormal_orbit_morphology1.61712274
26MP0002295_abnormal_pulmonary_circulatio1.60230273
27MP0005330_cardiomyopathy1.58203609
28MP0005508_abnormal_skeleton_morphology1.57946068
29MP0006138_congestive_heart_failure1.57395195
30MP0002108_abnormal_muscle_morphology1.56177361
31MP0000733_abnormal_muscle_development1.55865374
32MP0000767_abnormal_smooth_muscle1.51997153
33MP0002877_abnormal_melanocyte_morpholog1.51927380
34MP0004087_abnormal_muscle_fiber1.47354150
35MP0005666_abnormal_adipose_tissue1.46779061
36MP0001542_abnormal_bone_strength1.44724405
37MP0010352_gastrointestinal_tract_polyps1.43801973
38MP0000003_abnormal_adipose_tissue1.38024002
39MP0005375_adipose_tissue_phenotype1.35094381
40MP0004130_abnormal_muscle_cell1.33680865
41MP0008775_abnormal_heart_ventricle1.32098463
42MP0003941_abnormal_skin_development1.31932855
43MP0004185_abnormal_adipocyte_glucose1.29784001
44MP0002972_abnormal_cardiac_muscle1.29183310
45MP0004858_abnormal_nervous_system1.28522606
46MP0001849_ear_inflammation1.26918010
47MP0005385_cardiovascular_system_phenoty1.25381135
48MP0001544_abnormal_cardiovascular_syste1.25381135
49MP0010630_abnormal_cardiac_muscle1.24845820
50MP0004036_abnormal_muscle_relaxation1.23471623
51MP0005620_abnormal_muscle_contractility1.23101493
52* MP0003950_abnormal_plasma_membrane1.23032491
53MP0005409_darkened_coat_color1.22034174
54MP0003385_abnormal_body_wall1.19405248
55MP0002896_abnormal_bone_mineralization1.17345815
56MP0000759_abnormal_skeletal_muscle1.16462843
57MP0009250_abnormal_appendicular_skeleto1.16441327
58MP0001348_abnormal_lacrimal_gland1.15556153
59MP0001243_abnormal_dermal_layer1.14158397
60MP0000343_altered_response_to1.07525092
61MP0002128_abnormal_blood_circulation1.05871379
62MP0009278_abnormal_bone_marrow1.02789018
63MP0003045_fibrosis1.02214056
64MP0001299_abnormal_eye_distance/1.00491460
65MP0004215_abnormal_myocardial_fiber0.99653327
66MP0005595_abnormal_vascular_smooth0.96843704
67MP0001614_abnormal_blood_vessel0.96028034
68MP0000163_abnormal_cartilage_morphology0.95759701
69MP0005369_muscle_phenotype0.94133142
70MP0005257_abnormal_intraocular_pressure0.92272871
71MP0004484_altered_response_of0.91937813
72MP0000467_abnormal_esophagus_morphology0.89320285
73MP0002925_abnormal_cardiovascular_devel0.88238951
74MP0005390_skeleton_phenotype0.88006196
75MP0005388_respiratory_system_phenotype0.87792794
76MP0002133_abnormal_respiratory_system0.87792794
77MP0002282_abnormal_trachea_morphology0.87519470
78MP0005164_abnormal_response_to0.87453037
79MP0002234_abnormal_pharynx_morphology0.86698010
80MP0001915_intracranial_hemorrhage0.85672635
81MP0002106_abnormal_muscle_physiology0.84439016
82MP0002168_other_aberrant_phenotype0.84273407
83MP0000428_abnormal_craniofacial_morphol0.84169712
84MP0002115_abnormal_skeleton_extremities0.81562931
85MP0003115_abnormal_respiratory_system0.80100342
86MP0000266_abnormal_heart_morphology0.79312799
87MP0002933_joint_inflammation0.78866767
88MP0005197_abnormal_uvea_morphology0.78827992
89MP0000249_abnormal_blood_vessel0.78460674
90MP0000534_abnormal_ureter_morphology0.77033358
91MP0003448_altered_tumor_morphology0.76530665
92MP0001661_extended_life_span0.76395675
93MP0004233_abnormal_muscle_weight0.74992486
94MP0009780_abnormal_chondrocyte_physiolo0.74459932
95MP0004883_abnormal_blood_vessel0.74373442
96MP0003942_abnormal_urinary_system0.74037045
97MP0000762_abnormal_tongue_morphology0.74009520
98MP0002796_impaired_skin_barrier0.72460351
99MP0009115_abnormal_fat_cell0.72180740
100MP0002113_abnormal_skeleton_development0.72117075
101MP0001175_abnormal_lung_morphology0.72096181
102MP0002269_muscular_atrophy0.72029829
103MP0000858_altered_metastatic_potential0.71253683
104MP0000747_muscle_weakness0.71050317
105MP0005165_increased_susceptibility_to0.70792577
106MP0003191_abnormal_cellular_cholesterol0.68884083
107MP0004134_abnormal_chest_morphology0.68558244
108MP0003300_gastrointestinal_ulcer0.68336818
109MP0009379_abnormal_foot_pigmentation0.66559257
110MP0001533_abnormal_skeleton_physiology0.65932746
111MP0009053_abnormal_anal_canal0.65706339
112MP0002998_abnormal_bone_remodeling0.65321255
113MP0005076_abnormal_cell_differentiation0.65117178
114MP0000516_abnormal_urinary_system0.64660802
115MP0005193_abnormal_anterior_eye0.64388065
116MP0000462_abnormal_digestive_system0.64021940
117MP0009840_abnormal_foam_cell0.63904246
118MP0003755_abnormal_palate_morphology0.62870667
119MP0003453_abnormal_keratinocyte_physiol0.61226058
120MP0005501_abnormal_skin_physiology0.60617535
121MP0000432_abnormal_head_morphology0.58829687
122MP0010771_integument_phenotype0.57863723
123MP0005171_absent_coat_pigmentation0.56488964

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.82810387
2Protrusio acetabuli (HP:0003179)6.76709307
3Increased connective tissue (HP:0009025)4.90002800
4Ankle contracture (HP:0006466)4.66048009
5Aortic dissection (HP:0002647)4.37042271
6Type 1 muscle fiber predominance (HP:0003803)4.29894530
7Atrophic scars (HP:0001075)4.12693518
8Aortic aneurysm (HP:0004942)4.11016888
9Cerebral aneurysm (HP:0004944)3.99109408
10Broad metatarsal (HP:0001783)3.89269111
11Shallow orbits (HP:0000586)3.79019941
12* Spinal rigidity (HP:0003306)3.68063827
13Follicular hyperkeratosis (HP:0007502)3.64330369
14Soft skin (HP:0000977)3.56694095
15Fragile skin (HP:0001030)3.47493458
16Dilatation of the ascending aorta (HP:0005111)3.40247528
17Neonatal short-limb short stature (HP:0008921)3.35772150
18Bladder diverticulum (HP:0000015)3.32217869
19Muscle fiber splitting (HP:0003555)3.29543324
20Cervical subluxation (HP:0003308)3.28997232
21Mildly elevated creatine phosphokinase (HP:0008180)3.12833747
22Peritonitis (HP:0002586)3.09744854
23Increased variability in muscle fiber diameter (HP:0003557)3.08670866
24Abnormality of dentin (HP:0010299)3.07878203
25Right ventricular cardiomyopathy (HP:0011663)3.04505955
26Wormian bones (HP:0002645)2.98072362
27Abnormality of skeletal muscle fiber size (HP:0012084)2.92799828
28Difficulty climbing stairs (HP:0003551)2.78984555
29Blue sclerae (HP:0000592)2.76140576
30Lipoatrophy (HP:0100578)2.73879098
31Short nail (HP:0001799)2.73006835
32Spondylolisthesis (HP:0003302)2.71887046
33Mitral valve prolapse (HP:0001634)2.69551387
34Vertebral compression fractures (HP:0002953)2.66281817
35Aortic regurgitation (HP:0001659)2.62234201
36Vascular tortuosity (HP:0004948)2.61658447
37Wrist flexion contracture (HP:0001239)2.60715845
38Distal lower limb muscle weakness (HP:0009053)2.58385216
39Hyporeflexia of lower limbs (HP:0002600)2.57134965
40Osteolytic defects of the hand bones (HP:0009699)2.55308864
41Osteolytic defects of the phalanges of the hand (HP:0009771)2.55308864
42Aneurysm (HP:0002617)2.49080760
43Slender build (HP:0001533)2.46474843
44Scapular winging (HP:0003691)2.45986970
45Biconcave vertebral bodies (HP:0004586)2.36626865
46Ventricular tachycardia (HP:0004756)2.36423266
47Reduced subcutaneous adipose tissue (HP:0003758)2.34061456
48Distal lower limb amyotrophy (HP:0008944)2.30469880
49Elbow flexion contracture (HP:0002987)2.29012294
50Genu recurvatum (HP:0002816)2.27233499
51Aortic valve stenosis (HP:0001650)2.24229162
52Achilles tendon contracture (HP:0001771)2.22217312
53Abnormality of the calf musculature (HP:0001430)2.21577647
54Mitral stenosis (HP:0001718)2.19994885
55Disproportionate tall stature (HP:0001519)2.17732227
56Sudden death (HP:0001699)2.16996759
57Joint stiffness (HP:0001387)2.15910935
58Round ear (HP:0100830)2.15605805
59Hyperextensible skin (HP:0000974)2.15409243
60Overgrowth (HP:0001548)2.14641039
61Arterial tortuosity (HP:0005116)2.13583178
62Generalized amyotrophy (HP:0003700)2.13344652
63Hypoventilation (HP:0002791)2.09917639
64Joint laxity (HP:0001388)2.08475658
65Abnormality of the acetabulum (HP:0003170)2.08235074
66Difficulty running (HP:0009046)2.08156147
67Mesomelia (HP:0003027)2.07851736
68Abnormal delivery (HP:0001787)2.06919737
69Mitral regurgitation (HP:0001653)2.06494505
70Bowel diverticulosis (HP:0005222)2.05320523
71* Acanthosis nigricans (HP:0000956)2.02810098
72Venous abnormality (HP:0002624)1.98814243
73Pulmonary artery stenosis (HP:0004415)1.98671583
74Wide anterior fontanel (HP:0000260)1.95850624
75Lower limb amyotrophy (HP:0007210)1.95465024
76Breech presentation (HP:0001623)1.95328426
77EMG: myopathic abnormalities (HP:0003458)1.94255496
78Distal upper limb amyotrophy (HP:0007149)1.93843429
79Upper limb amyotrophy (HP:0009129)1.93843429
80Camptodactyly of toe (HP:0001836)1.93258853
81Hyperacusis (HP:0010780)1.92720560
82Nonimmune hydrops fetalis (HP:0001790)1.92321384
83Abnormality of carpal bone ossification (HP:0006257)1.91642511
84Abnormality of the Achilles tendon (HP:0005109)1.91343151
85Long toe (HP:0010511)1.91173084
86Abnormal ossification of hand bones (HP:0005921)1.90833261
87Cardiovascular calcification (HP:0011915)1.89922236
88Enlarged penis (HP:0000040)1.89438779
89Coronal craniosynostosis (HP:0004440)1.88709689
90Thin bony cortex (HP:0002753)1.88684413
91Alopecia of scalp (HP:0002293)1.88440979
92Hypoplastic ischia (HP:0003175)1.87985316
93Spinal cord lesions (HP:0100561)1.85869104
94Syringomyelia (HP:0003396)1.85869104
95Exercise-induced muscle cramps (HP:0003710)1.85179234
96Abnormality of the calcaneus (HP:0008364)1.85135474
97Ectopia lentis (HP:0001083)1.84397795
98Congenital, generalized hypertrichosis (HP:0004540)1.83427614
99Bowing of the arm (HP:0006488)1.82361105
100Bowed forearm bones (HP:0003956)1.82361105
101Broad face (HP:0000283)1.82086785
102Hip contracture (HP:0003273)1.81237462
103Delayed cranial suture closure (HP:0000270)1.80832520
104Knee flexion contracture (HP:0006380)1.80164841
105Coxa vara (HP:0002812)1.79514455
106Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.78429181
107* Atrial fibrillation (HP:0005110)1.78264895
108Ulnar bowing (HP:0003031)1.78003590
109Cupped ribs (HP:0000887)1.77551396
110Natal tooth (HP:0000695)1.77543614
111Protruding ear (HP:0000411)1.76992302
112Platyspondyly (HP:0000926)1.74510000
113Advanced eruption of teeth (HP:0006288)1.74078737
114Entropion (HP:0000621)1.73955495
115Limb-girdle muscle weakness (HP:0003325)1.73207138
116Thin skin (HP:0000963)1.72124633
117Limb-girdle muscle atrophy (HP:0003797)1.71201841
118Dilated cardiomyopathy (HP:0001644)1.70738175
119Absent frontal sinuses (HP:0002688)1.69770037
120Short clavicles (HP:0000894)1.69108973
121Radial bowing (HP:0002986)1.69040257
122Abnormality of the left ventricular outflow tract (HP:0011103)1.68961215
123Subaortic stenosis (HP:0001682)1.68961215
124Inguinal hernia (HP:0000023)1.68918935
125Abnormality of the ischium (HP:0003174)1.67256475
126Rectal prolapse (HP:0002035)1.66932281
127Deviation of the hallux (HP:0010051)1.66517853
128Osteoarthritis (HP:0002758)1.66367258
129Hypoplasia of the iris (HP:0007676)1.65613059
130Hallux valgus (HP:0001822)1.65308103
131Hydroureter (HP:0000072)1.65296753
132Back pain (HP:0003418)1.64836512

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.26179843
2TTN4.09860861
3TIE13.26565683
4DDR23.12507505
5MYLK2.82133562
6PDGFRA2.53931868
7TRPM72.44116442
8PKN22.38428184
9NTRK12.37496221
10LATS22.35270923
11EPHB22.30217690
12LATS12.06798000
13MAP3K31.95368206
14ERN11.90481803
15RIPK11.89956232
16TGFBR21.89677921
17PAK21.84497263
18TESK11.74851332
19FER1.67341304
20SIK11.66904682
21PDK21.66077741
22DMPK1.62925552
23PTK2B1.54085051
24PIK3CA1.48241241
25LIMK11.46163426
26KDR1.42613456
27STK38L1.39288601
28STK381.39192479
29ILK1.38159982
30INSRR1.36049911
31MAP2K31.31550667
32ICK1.29244138
33PIM21.28911713
34LRRK21.28732425
35PTK21.27666918
36EPHA21.25030805
37ERBB41.24084003
38LMTK21.23942470
39IRAK31.21423416
40PTK61.21226323
41CAMK1D1.20075324
42TGFBR11.20069399
43SMG11.19646947
44BMX1.18465678
45MET1.18182505
46EPHA31.17435379
47MAP3K61.17243349
48ZAK1.13832699
49PAK41.13269968
50MOS1.13171190
51PAK31.12734051
52MAPKAPK31.12101520
53ROCK11.10314725
54PDK41.10042925
55PDK31.10042925
56ABL21.09609722
57OBSCN1.08224468
58FRK1.08015139
59ARAF1.03105999
60EEF2K1.02853319
61MAP2K11.01770935
62PRKG21.01231744
63RPS6KA40.99755254
64NEK90.96980444
65ERBB30.93865543
66STK30.92460548
67AKT30.91657515
68RPS6KA20.88955726
69CDK80.88006664
70PAK60.86553801
71EPHB10.84896896
72PDGFRB0.81521870
73MAP3K80.81427347
74ADRBK10.80566305
75PIK3CG0.77671603
76MTOR0.77172002
77PRPF4B0.76807812
78FGFR10.75844687
79PRKD10.75514665
80STK240.75179416
81BCKDK0.71939177
82DAPK30.67976533
83MST1R0.64894150
84FLT30.63731849
85CDK120.62703685
86SCYL20.62291678
87MELK0.62001229
88PRKD30.61164866
89CDK60.61104677
90CDC42BPA0.58561468
91KSR20.57013260
92ROCK20.56172495
93NME20.53693752
94STK100.53534444
95FGFR40.51775749
96INSR0.48596257
97CAMK2G0.47970448
98NLK0.47376073
99TAOK20.46581028
100CAMK1G0.46396862
101MAPK120.45961531
102WNK10.44559556
103PHKG10.42548442
104PHKG20.42548442
105NEK10.42094909
106PRKD20.42035296
107PAK10.41223440
108CLK10.41161469
109MAPKAPK20.39568463
110RET0.39499007
111FGFR30.39234437
112IGF1R0.38645272
113NUAK10.37828467
114CDK90.37286034
115PRKAA20.36824733
116TESK20.34903588
117SRC0.34656600
118ZAP700.33881617
119TAOK10.33681013
120GSK3A0.33498113
121MAP3K120.33256150
122PRKCH0.32568745
123MAP3K70.32058081
124MAP3K50.30485463
125RPS6KB20.29968881
126BRAF0.29785936
127MUSK0.29688655
128MAPK70.29549278
129GRK70.29283543
130MARK20.28989506
131MAP2K20.27668039
132RPS6KC10.27621493
133RPS6KL10.27621493
134MAP3K130.27108975
135PDPK10.25408350
136JAK30.23384365

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.20986784
2Focal adhesion_Homo sapiens_hsa045103.27676348
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.02140319
4Dilated cardiomyopathy_Homo sapiens_hsa054142.92606458
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.55985951
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.49696139
7Adherens junction_Homo sapiens_hsa045202.48633738
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.28865660
9Proteoglycans in cancer_Homo sapiens_hsa052052.25951118
10Protein digestion and absorption_Homo sapiens_hsa049742.19485596
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.13600497
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.09164581
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.00373664
14Amoebiasis_Homo sapiens_hsa051461.98529150
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.97746607
16Small cell lung cancer_Homo sapiens_hsa052221.95169523
17TGF-beta signaling pathway_Homo sapiens_hsa043501.76641842
18Viral myocarditis_Homo sapiens_hsa054161.72294135
19PPAR signaling pathway_Homo sapiens_hsa033201.70945551
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.61911260
21Bladder cancer_Homo sapiens_hsa052191.56851083
22Hippo signaling pathway_Homo sapiens_hsa043901.56102174
23PI3K-Akt signaling pathway_Homo sapiens_hsa041511.55813179
24Malaria_Homo sapiens_hsa051441.55357454
25Tight junction_Homo sapiens_hsa045301.48841508
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40448090
27MicroRNAs in cancer_Homo sapiens_hsa052061.37228189
28HIF-1 signaling pathway_Homo sapiens_hsa040661.28953405
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28614056
30Regulation of actin cytoskeleton_Homo sapiens_hsa048101.27210655
31Chronic myeloid leukemia_Homo sapiens_hsa052201.20843866
32Prion diseases_Homo sapiens_hsa050201.19569963
33Other glycan degradation_Homo sapiens_hsa005111.19262390
34Basal cell carcinoma_Homo sapiens_hsa052171.17302499
35Adipocytokine signaling pathway_Homo sapiens_hsa049201.16770898
36Platelet activation_Homo sapiens_hsa046111.15480643
37Propanoate metabolism_Homo sapiens_hsa006401.14770777
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11176678
39Melanoma_Homo sapiens_hsa052181.10705994
40Shigellosis_Homo sapiens_hsa051311.09026003
41Fatty acid biosynthesis_Homo sapiens_hsa000611.06889503
42Fatty acid metabolism_Homo sapiens_hsa012121.05996915
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04699984
44AMPK signaling pathway_Homo sapiens_hsa041521.03740943
45Rap1 signaling pathway_Homo sapiens_hsa040151.02339339
46Pathways in cancer_Homo sapiens_hsa052001.01832482
47Fatty acid degradation_Homo sapiens_hsa000711.01507490
48Insulin resistance_Homo sapiens_hsa049311.00826058
49Toxoplasmosis_Homo sapiens_hsa051451.00496881
50Pentose phosphate pathway_Homo sapiens_hsa000300.93538024
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.90494151
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.86049059
53Ovarian steroidogenesis_Homo sapiens_hsa049130.85522790
54Galactose metabolism_Homo sapiens_hsa000520.85256204
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82523237
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82469289
57Vibrio cholerae infection_Homo sapiens_hsa051100.82221094
58p53 signaling pathway_Homo sapiens_hsa041150.81303397
59N-Glycan biosynthesis_Homo sapiens_hsa005100.81142463
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80443740
61HTLV-I infection_Homo sapiens_hsa051660.80144714
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80012782
63Prostate cancer_Homo sapiens_hsa052150.78799574
64Thyroid cancer_Homo sapiens_hsa052160.76746957
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76706402
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76270968
67Pancreatic cancer_Homo sapiens_hsa052120.74654485
68Cardiac muscle contraction_Homo sapiens_hsa042600.73739409
69TNF signaling pathway_Homo sapiens_hsa046680.73402829
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73353497
71Insulin signaling pathway_Homo sapiens_hsa049100.71797430
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71416471
73Carbon metabolism_Homo sapiens_hsa012000.68789755
74GnRH signaling pathway_Homo sapiens_hsa049120.67266672
75Hedgehog signaling pathway_Homo sapiens_hsa043400.67121764
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66283117
77Apoptosis_Homo sapiens_hsa042100.66014333
78Salmonella infection_Homo sapiens_hsa051320.62806367
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62077973
80Glioma_Homo sapiens_hsa052140.61470468
81Notch signaling pathway_Homo sapiens_hsa043300.59982770
82Axon guidance_Homo sapiens_hsa043600.59094958
83Renal cell carcinoma_Homo sapiens_hsa052110.58993476
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57584654
85Gap junction_Homo sapiens_hsa045400.57270903
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55591513
87ErbB signaling pathway_Homo sapiens_hsa040120.55499934
88FoxO signaling pathway_Homo sapiens_hsa040680.52885534
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52613083
90Wnt signaling pathway_Homo sapiens_hsa043100.52465407
91Complement and coagulation cascades_Homo sapiens_hsa046100.52299331
92Glucagon signaling pathway_Homo sapiens_hsa049220.52040456
93Non-small cell lung cancer_Homo sapiens_hsa052230.51382072
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49678959
95Acute myeloid leukemia_Homo sapiens_hsa052210.48082279
96Endometrial cancer_Homo sapiens_hsa052130.47539944
97Melanogenesis_Homo sapiens_hsa049160.47531408
98Sulfur metabolism_Homo sapiens_hsa009200.47499253
99VEGF signaling pathway_Homo sapiens_hsa043700.46080513
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45429184
101Ras signaling pathway_Homo sapiens_hsa040140.44962938
102Lysosome_Homo sapiens_hsa041420.44161389
103Endocytosis_Homo sapiens_hsa041440.43698414
104Estrogen signaling pathway_Homo sapiens_hsa049150.43043188
105MAPK signaling pathway_Homo sapiens_hsa040100.42761447
106Fructose and mannose metabolism_Homo sapiens_hsa000510.41909445
107Thyroid hormone synthesis_Homo sapiens_hsa049180.41352418
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41034811
109mTOR signaling pathway_Homo sapiens_hsa041500.41012056
110Pertussis_Homo sapiens_hsa051330.40858787
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40168743
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38144354
113Oxytocin signaling pathway_Homo sapiens_hsa049210.36590162
114Colorectal cancer_Homo sapiens_hsa052100.36077621
115Phagosome_Homo sapiens_hsa041450.35533457
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.35364612
117Viral carcinogenesis_Homo sapiens_hsa052030.35306605
118Caffeine metabolism_Homo sapiens_hsa002320.35242262
119Pyruvate metabolism_Homo sapiens_hsa006200.33775799
120Starch and sucrose metabolism_Homo sapiens_hsa005000.33466349
121Hepatitis B_Homo sapiens_hsa051610.32750283
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.31897416
123Renin-angiotensin system_Homo sapiens_hsa046140.31366595

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