PTPRZ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1auditory behavior (GO:0031223)7.32430232
2startle response (GO:0001964)5.94956608
3innervation (GO:0060384)5.84233741
4response to auditory stimulus (GO:0010996)5.69605949
5neuron cell-cell adhesion (GO:0007158)5.55529853
6mechanosensory behavior (GO:0007638)5.47989600
7locomotory exploration behavior (GO:0035641)5.13070355
8pyrimidine nucleobase catabolic process (GO:0006208)4.82763543
9neurotransmitter uptake (GO:0001504)4.75683419
10chondroitin sulfate catabolic process (GO:0030207)4.65611453
11postsynaptic membrane organization (GO:0001941)4.62118998
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.34726330
13amino acid import (GO:0043090)4.31138540
14alanine transport (GO:0032328)4.30555891
15dermatan sulfate biosynthetic process (GO:0030208)4.28141027
16neurotransmitter-gated ion channel clustering (GO:0072578)4.22431956
17layer formation in cerebral cortex (GO:0021819)4.20053775
18L-amino acid import (GO:0043092)4.17868407
19dermatan sulfate metabolic process (GO:0030205)4.15791019
20presynaptic membrane assembly (GO:0097105)4.14965661
21vocalization behavior (GO:0071625)4.11290068
22phenol-containing compound catabolic process (GO:0019336)4.09384714
23gamma-aminobutyric acid transport (GO:0015812)4.04262506
24C4-dicarboxylate transport (GO:0015740)3.97592223
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.96134935
26regulation of cardiac muscle cell contraction (GO:0086004)3.91795263
27positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.87151822
28ionotropic glutamate receptor signaling pathway (GO:0035235)3.83127730
29cochlea development (GO:0090102)3.79523701
30regulation of timing of cell differentiation (GO:0048505)3.78492630
31cerebellar granule cell differentiation (GO:0021707)3.78280334
32regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.76422901
33exploration behavior (GO:0035640)3.73517828
34nucleobase catabolic process (GO:0046113)3.72759722
35cellular potassium ion homeostasis (GO:0030007)3.71588022
36glial cell proliferation (GO:0014009)3.71305913
37glutamate receptor signaling pathway (GO:0007215)3.69644700
38neuronal action potential propagation (GO:0019227)3.69541131
39regulation of glutamate receptor signaling pathway (GO:1900449)3.67455669
40response to pheromone (GO:0019236)3.64039063
41regulation of short-term neuronal synaptic plasticity (GO:0048172)3.63012526
42cell morphogenesis involved in neuron differentiation (GO:0048667)3.62063014
43negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.59227388
44astrocyte differentiation (GO:0048708)3.59140476
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.57588426
46negative regulation of sodium ion transport (GO:0010766)3.57477312
47negative regulation of cytosolic calcium ion concentration (GO:0051481)3.53784103
48sodium ion export (GO:0071436)3.53043119
49olfactory bulb development (GO:0021772)3.52891180
50protein localization to synapse (GO:0035418)3.49543320
51limb bud formation (GO:0060174)3.48523933
52membrane assembly (GO:0071709)3.47708001
53cell communication by electrical coupling (GO:0010644)3.47705727
54positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.47648081
55synaptic transmission, glutamatergic (GO:0035249)3.47228770
56presynaptic membrane organization (GO:0097090)3.46247461
57gonadal mesoderm development (GO:0007506)3.45892830
58synapse assembly (GO:0007416)3.43515917
59prepulse inhibition (GO:0060134)3.43355970
60proline transport (GO:0015824)3.42571443
61negative regulation of neurotransmitter transport (GO:0051589)3.41821839
62cellular response to sterol (GO:0036315)3.40470636
63central nervous system projection neuron axonogenesis (GO:0021952)3.38734508
64dendrite morphogenesis (GO:0048813)3.38139032
65regulation of synapse structural plasticity (GO:0051823)3.35403377
66tongue development (GO:0043586)3.32002643
67reflex (GO:0060004)3.31623971
68regulation of synaptic transmission, glutamatergic (GO:0051966)3.31623845
69negative regulation of smoothened signaling pathway (GO:0045879)3.30365252
70regulation of phospholipid biosynthetic process (GO:0071071)3.29889481
71acidic amino acid transport (GO:0015800)3.29635356
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.27956301
73regulation of development, heterochronic (GO:0040034)3.27938235
74negative regulation of oligodendrocyte differentiation (GO:0048715)3.24330068
75regulation of respiratory system process (GO:0044065)3.22649960
76axonal fasciculation (GO:0007413)3.22177673
77cerebral cortex cell migration (GO:0021795)3.18088886
78L-serine transport (GO:0015825)3.14844072
79photoreceptor cell differentiation (GO:0046530)3.13047339
80eye photoreceptor cell differentiation (GO:0001754)3.13047339
81positive regulation of synapse assembly (GO:0051965)3.08688964
82* oligodendrocyte differentiation (GO:0048709)3.07970009
83cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.07918865
84L-glutamate transport (GO:0015813)3.07791104
85transmission of nerve impulse (GO:0019226)3.06104939
86synapse organization (GO:0050808)3.04865736
87long-term synaptic potentiation (GO:0060291)3.02531764
88negative regulation of astrocyte differentiation (GO:0048712)3.00783841
89calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.99974331
90membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.98958421
91cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.98017331
92nonmotile primary cilium assembly (GO:0035058)2.97605572
93regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.95123598
94negative regulation of synaptic transmission, GABAergic (GO:0032229)2.94687069
95fatty acid elongation (GO:0030497)2.93584882
96otic vesicle formation (GO:0030916)2.91965161
97regulation of actin filament-based movement (GO:1903115)2.91832911
98regulation of respiratory gaseous exchange (GO:0043576)2.89137366
99glutamate secretion (GO:0014047)2.89069746
100cerebellar Purkinje cell layer development (GO:0021680)2.87049232
101synaptic vesicle exocytosis (GO:0016079)2.86802012
102cranial nerve development (GO:0021545)2.86426763
103positive regulation of synapse maturation (GO:0090129)2.84105081
104axon regeneration (GO:0031103)2.83769906
105regulation of translation, ncRNA-mediated (GO:0045974)2.83740117
106negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.83740117
107negative regulation of translation, ncRNA-mediated (GO:0040033)2.83740117
108forebrain neuron differentiation (GO:0021879)2.83386306
109negative regulation of protein localization to cell surface (GO:2000009)2.82627183
110regulation of sister chromatid cohesion (GO:0007063)2.81797456
111neuron-neuron synaptic transmission (GO:0007270)2.81053407
112synaptic vesicle maturation (GO:0016188)2.81002341
113heart valve formation (GO:0003188)2.80170195
114appendage development (GO:0048736)2.79956107
115limb development (GO:0060173)2.79956107
116central nervous system neuron axonogenesis (GO:0021955)2.79920614
117long-chain fatty acid biosynthetic process (GO:0042759)2.78650840
118dicarboxylic acid biosynthetic process (GO:0043650)2.78423049
119positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.77168169
120atrial cardiac muscle cell action potential (GO:0086014)2.77005076
121neuronal stem cell maintenance (GO:0097150)2.76902808
122positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.76510488
123neuron fate determination (GO:0048664)2.76271301
124axon ensheathment in central nervous system (GO:0032291)2.76071011
125central nervous system myelination (GO:0022010)2.76071011
126regulation of neuron projection regeneration (GO:0070570)2.75760811
127regulation of axon regeneration (GO:0048679)2.75760811
128neurotransmitter secretion (GO:0007269)2.74151413
129regulation of inositol phosphate biosynthetic process (GO:0010919)2.74115423
130ovulation cycle (GO:0042698)2.72808164
131cellular response to cholesterol (GO:0071397)2.72242022
132neuron recognition (GO:0008038)2.72000398
133chondroitin sulfate biosynthetic process (GO:0030206)2.71873133
134L-serine metabolic process (GO:0006563)2.69475224
135cerebral cortex radially oriented cell migration (GO:0021799)2.69283126
136mesenchymal-epithelial cell signaling (GO:0060638)2.68550054
137hormone catabolic process (GO:0042447)2.68387281
138gamma-aminobutyric acid signaling pathway (GO:0007214)2.67702923
139potassium ion import (GO:0010107)2.67525708
140potassium ion homeostasis (GO:0055075)2.66914617
141negative regulation of transcription regulatory region DNA binding (GO:2000678)2.65195230
142regulation of neuronal synaptic plasticity (GO:0048168)2.65134048
143negative regulation of glial cell differentiation (GO:0045686)2.64860996
144cellular sodium ion homeostasis (GO:0006883)2.64711164
145lateral sprouting from an epithelium (GO:0060601)2.63772118
146regulation of long-term neuronal synaptic plasticity (GO:0048169)2.62137821
147regulation of astrocyte differentiation (GO:0048710)2.61729973
148serine transport (GO:0032329)2.60933249
149regulation of synaptic vesicle exocytosis (GO:2000300)2.60185277
150dendritic spine morphogenesis (GO:0060997)2.59781243

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.29476106
2GBX2_23144817_ChIP-Seq_PC3_Human3.82318949
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05547358
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04862649
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.02093071
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95437782
7AR_21572438_ChIP-Seq_LNCaP_Human2.93445037
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.87046727
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81703651
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.79213216
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.74419677
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.64467170
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62344185
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60354861
15* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54227188
16* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54227188
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53941989
18IGF1R_20145208_ChIP-Seq_DFB_Human2.48851249
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.37236555
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.31807511
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13880421
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12658150
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.07164890
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.06622557
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02531856
26REST_21632747_ChIP-Seq_MESCs_Mouse2.01473889
27DROSHA_22980978_ChIP-Seq_HELA_Human1.94938226
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.94419032
29PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.89801866
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86704983
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76243995
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.69102690
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69101840
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.66136624
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65727001
36* EWS_26573619_Chip-Seq_HEK293_Human1.64492705
37* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61347817
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.59147430
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58190172
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57297844
41TAF15_26573619_Chip-Seq_HEK293_Human1.57277506
42* SMAD4_21799915_ChIP-Seq_A2780_Human1.56933286
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.56675166
44* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54516338
45SOX9_26525672_Chip-Seq_HEART_Mouse1.53263764
46ER_23166858_ChIP-Seq_MCF-7_Human1.52060598
47RING1B_27294783_Chip-Seq_ESCs_Mouse1.50787550
48* P300_19829295_ChIP-Seq_ESCs_Human1.48907159
49ZNF274_21170338_ChIP-Seq_K562_Hela1.47783964
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46247066
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.45369572
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44542721
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.41332140
54KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.40120824
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37602947
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37389274
57STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.37351149
58* SOX2_21211035_ChIP-Seq_LN229_Gbm1.34842658
59TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.33500236
60RARB_27405468_Chip-Seq_BRAIN_Mouse1.32855606
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32163029
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31332043
63TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27676257
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27476195
65AR_19668381_ChIP-Seq_PC3_Human1.26692938
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25826974
67AR_25329375_ChIP-Seq_VCAP_Human1.25761516
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25403299
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25114911
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24918729
71FUS_26573619_Chip-Seq_HEK293_Human1.24626221
72* STAT3_23295773_ChIP-Seq_U87_Human1.24243184
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22588601
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.21237527
75CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.20915453
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.20911695
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.20745817
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18899254
79AHR_22903824_ChIP-Seq_MCF-7_Human1.16400733
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15823521
81BCAT_22108803_ChIP-Seq_LS180_Human1.15596355
82POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14302254
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13257164
84VDR_22108803_ChIP-Seq_LS180_Human1.13251718
85TP53_20018659_ChIP-ChIP_R1E_Mouse1.13063463
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12564536
87EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12379058
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12260342
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11794365
90YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11766774
91POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.11362753
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11224245
93TRIM28_21343339_ChIP-Seq_HEK293_Human1.10729905
94TP53_16413492_ChIP-PET_HCT116_Human1.10112395
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09781265
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09391740
97TCF4_22108803_ChIP-Seq_LS180_Human1.09281534
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09048254
99MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08939722
100SMAD3_21741376_ChIP-Seq_HESCs_Human1.08065076
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07547219
102TAL1_26923725_Chip-Seq_HPCs_Mouse1.07239995
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07143099
104KDM2B_26808549_Chip-Seq_REH_Human1.06912310
105* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06380768
106SMAD3_21741376_ChIP-Seq_ESCs_Human1.06100081
107TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05067044
108SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.04881594
109TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04524607
110RUNX2_22187159_ChIP-Seq_PCA_Human1.04493894
111RNF2_27304074_Chip-Seq_NSC_Mouse1.04226899
112* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04208294
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03538732
114TCF4_23295773_ChIP-Seq_U87_Human1.01975439
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00651206
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00651206
117ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98666738
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98232056
119RXR_22108803_ChIP-Seq_LS180_Human0.98046044
120TP53_18474530_ChIP-ChIP_U2OS_Human0.97831492
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97820082
122ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97218663
123PRDM14_20953172_ChIP-Seq_ESCs_Human0.96787599
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.94234006
125LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94218052
126JUN_21703547_ChIP-Seq_K562_Human0.93919823

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.59256679
2MP0003136_yellow_coat_color4.50276743
3MP0003880_abnormal_central_pattern3.23950937
4MP0004858_abnormal_nervous_system3.17759150
5* MP0003635_abnormal_synaptic_transmissio2.98682457
6MP0005423_abnormal_somatic_nervous2.85892380
7MP0001486_abnormal_startle_reflex2.62692801
8MP0000778_abnormal_nervous_system2.58753670
9MP0009745_abnormal_behavioral_response2.43327248
10MP0005171_absent_coat_pigmentation2.36342236
11MP0004270_analgesia2.36243568
12* MP0002063_abnormal_learning/memory/cond2.32765699
13MP0005646_abnormal_pituitary_gland2.32305186
14MP0002064_seizures2.28245705
15MP0002572_abnormal_emotion/affect_behav2.27928756
16MP0001502_abnormal_circadian_rhythm2.27925053
17MP0004885_abnormal_endolymph2.27681837
18MP0001984_abnormal_olfaction2.19093041
19MP0003868_abnormal_feces_composition2.18646728
20MP0008789_abnormal_olfactory_epithelium2.13457125
21MP0003941_abnormal_skin_development2.10671059
22MP0009046_muscle_twitch2.08038056
23MP0002184_abnormal_innervation1.87577718
24MP0002557_abnormal_social/conspecific_i1.87337281
25* MP0002067_abnormal_sensory_capabilities1.86313438
26MP0005248_abnormal_Harderian_gland1.85264153
27MP0000566_synostosis1.81289728
28MP0003690_abnormal_glial_cell1.78592243
29MP0002734_abnormal_mechanical_nocicepti1.71047631
30MP0000631_abnormal_neuroendocrine_gland1.66621365
31MP0002272_abnormal_nervous_system1.66218887
32MP0005645_abnormal_hypothalamus_physiol1.60844249
33MP0000955_abnormal_spinal_cord1.58865183
34MP0001958_emphysema1.54330595
35MP0000569_abnormal_digit_pigmentation1.53535521
36MP0009053_abnormal_anal_canal1.52435981
37MP0004742_abnormal_vestibular_system1.49872291
38MP0001440_abnormal_grooming_behavior1.48976822
39* MP0003634_abnormal_glial_cell1.48423175
40MP0008569_lethality_at_weaning1.48229379
41MP0000579_abnormal_nail_morphology1.46818687
42* MP0001968_abnormal_touch/_nociception1.46478619
43MP0002234_abnormal_pharynx_morphology1.44471817
44MP0002882_abnormal_neuron_morphology1.38855114
45MP0008961_abnormal_basal_metabolism1.37450079
46MP0005551_abnormal_eye_electrophysiolog1.35372539
47MP0001293_anophthalmia1.35262089
48MP0002152_abnormal_brain_morphology1.33624838
49MP0009780_abnormal_chondrocyte_physiolo1.32834040
50MP0003937_abnormal_limbs/digits/tail_de1.32511179
51MP0001529_abnormal_vocalization1.31602685
52MP0002653_abnormal_ependyma_morphology1.29807540
53MP0003329_amyloid_beta_deposits1.29782184
54MP0004142_abnormal_muscle_tone1.29383936
55MP0000026_abnormal_inner_ear1.28772181
56MP0003632_abnormal_nervous_system1.24778570
57MP0010234_abnormal_vibrissa_follicle1.24519248
58MP0000647_abnormal_sebaceous_gland1.24299180
59MP0005167_abnormal_blood-brain_barrier1.23854292
60MP0005391_vision/eye_phenotype1.22955153
61MP0001299_abnormal_eye_distance/1.21042927
62MP0004811_abnormal_neuron_physiology1.17656297
63MP0006276_abnormal_autonomic_nervous1.16223975
64* MP0002736_abnormal_nociception_after1.15615615
65* MP0002066_abnormal_motor_capabilities/c1.13495451
66MP0009384_cardiac_valve_regurgitation1.12417447
67MP0002735_abnormal_chemical_nociception1.12407788
68* MP0001970_abnormal_pain_threshold1.11027220
69MP0001963_abnormal_hearing_physiology1.10829629
70MP0001501_abnormal_sleep_pattern1.10551656
71MP0005257_abnormal_intraocular_pressure1.10483540
72MP0004215_abnormal_myocardial_fiber1.09916719
73MP0005367_renal/urinary_system_phenotyp1.09533911
74MP0000516_abnormal_urinary_system1.09533911
75MP0005195_abnormal_posterior_eye1.09359374
76MP0002751_abnormal_autonomic_nervous1.08127978
77MP0003787_abnormal_imprinting1.07168772
78MP0002752_abnormal_somatic_nervous1.06371308
79MP0005187_abnormal_penis_morphology1.05355816
80MP0005253_abnormal_eye_physiology1.05096081
81MP0003861_abnormal_nervous_system1.05023170
82MP0002249_abnormal_larynx_morphology1.04987080
83MP0002090_abnormal_vision1.04663165
84* MP0002733_abnormal_thermal_nociception1.03954564
85MP0002938_white_spotting1.03358672
86MP0003633_abnormal_nervous_system1.03148544
87MP0000428_abnormal_craniofacial_morphol1.02633501
88MP0001177_atelectasis1.02040275
89MP0002092_abnormal_eye_morphology1.00677742
90MP0001485_abnormal_pinna_reflex1.00412695
91MP0005386_behavior/neurological_phenoty1.00009782
92MP0004924_abnormal_behavior1.00009782
93MP0004130_abnormal_muscle_cell0.99817662
94MP0003122_maternal_imprinting0.99432191
95MP0003631_nervous_system_phenotype0.98633700
96MP0009250_abnormal_appendicular_skeleto0.98229667
97MP0002697_abnormal_eye_size0.98198790
98MP0003755_abnormal_palate_morphology0.98112313
99MP0000383_abnormal_hair_follicle0.97352044
100MP0002089_abnormal_postnatal_growth/wei0.95055414
101MP0006292_abnormal_olfactory_placode0.94501521
102MP0000049_abnormal_middle_ear0.93954445
103MP0003935_abnormal_craniofacial_develop0.93680945
104MP0003115_abnormal_respiratory_system0.92941846
105MP0000537_abnormal_urethra_morphology0.92498471
106MP0000534_abnormal_ureter_morphology0.92031984
107MP0003938_abnormal_ear_development0.90604122
108MP0003119_abnormal_digestive_system0.89910808
109MP0002282_abnormal_trachea_morphology0.89735509
110MP0003121_genomic_imprinting0.89680219
111MP0001286_abnormal_eye_development0.87438347
112MP0003942_abnormal_urinary_system0.85132140
113MP0002116_abnormal_craniofacial_bone0.84937635
114MP0003183_abnormal_peptide_metabolism0.84736223
115MP0000613_abnormal_salivary_gland0.83095320
116MP0006072_abnormal_retinal_apoptosis0.82641821
117MP0002095_abnormal_skin_pigmentation0.82336430
118MP0002098_abnormal_vibrissa_morphology0.82329316
119MP0002638_abnormal_pupillary_reflex0.78937935
120MP0001943_abnormal_respiration0.77938281
121MP0002233_abnormal_nose_morphology0.77472943
122MP0005409_darkened_coat_color0.76027945
123* MP0000920_abnormal_myelination0.75084563
124MP0003137_abnormal_impulse_conducting0.71623605
125MP0003385_abnormal_body_wall0.70704458
126MP0005394_taste/olfaction_phenotype0.70258287
127MP0005499_abnormal_olfactory_system0.70258287
128MP0001905_abnormal_dopamine_level0.69824272
129MP0002069_abnormal_eating/drinking_beha0.68765359

Predicted human phenotypes

RankGene SetZ-score
1Aplasia of the phalanges of the hand (HP:0009802)4.33470481
2Aplasia involving bones of the extremities (HP:0009825)4.33470481
3Aplasia involving bones of the upper limbs (HP:0009823)4.33470481
4Hepatoblastoma (HP:0002884)4.16437574
5Humeroradial synostosis (HP:0003041)3.99367151
6Synostosis involving the elbow (HP:0003938)3.99367151
7Megalencephaly (HP:0001355)3.83385935
8Colon cancer (HP:0003003)3.74594336
9Focal motor seizures (HP:0011153)3.38855681
10Hemiparesis (HP:0001269)3.37376490
11Myokymia (HP:0002411)3.16130038
12Oligodactyly (hands) (HP:0001180)3.15063475
13Aqueductal stenosis (HP:0002410)2.95608457
14Medulloblastoma (HP:0002885)2.93540404
15Septo-optic dysplasia (HP:0100842)2.92186953
16Hemiplegia (HP:0002301)2.86441507
17Progressive cerebellar ataxia (HP:0002073)2.86313543
18Epileptic encephalopathy (HP:0200134)2.82985334
19Glioma (HP:0009733)2.78225009
20Intestinal atresia (HP:0011100)2.74100752
21Abnormality of the astrocytes (HP:0100707)2.73718479
22Astrocytoma (HP:0009592)2.73718479
23Papillary thyroid carcinoma (HP:0002895)2.71363935
24Action tremor (HP:0002345)2.68386798
25Epidermoid cyst (HP:0200040)2.68205906
26Stomach cancer (HP:0012126)2.67782682
27Neoplasm of the oral cavity (HP:0100649)2.65114085
28Large earlobe (HP:0009748)2.62735304
29Congenital primary aphakia (HP:0007707)2.62378992
30Medial flaring of the eyebrow (HP:0010747)2.61298934
31Spastic gait (HP:0002064)2.57711027
32Oligodactyly (HP:0012165)2.55531174
33Diplopia (HP:0000651)2.53393515
34Abnormality of binocular vision (HP:0011514)2.53393515
35Gastrointestinal atresia (HP:0002589)2.53287106
36Retinal dysplasia (HP:0007973)2.52145148
37Focal seizures (HP:0007359)2.51720071
38Genital tract atresia (HP:0001827)2.50717428
39Split foot (HP:0001839)2.50215738
40Germ cell neoplasia (HP:0100728)2.49552132
41Hyperventilation (HP:0002883)2.46691986
42Aplasia/Hypoplasia of the sternum (HP:0006714)2.42352713
43Fibular aplasia (HP:0002990)2.41281865
44Bronchomalacia (HP:0002780)2.39846798
45Vaginal atresia (HP:0000148)2.39121351
46Increased nuchal translucency (HP:0010880)2.37395083
47Blue irides (HP:0000635)2.36398756
48Nephrogenic diabetes insipidus (HP:0009806)2.36292036
49Neoplasm of the adrenal cortex (HP:0100641)2.32565238
50Vitreoretinal degeneration (HP:0000655)2.32257795
51Abnormality of the labia minora (HP:0012880)2.29780543
52Skull defect (HP:0001362)2.27951824
53Protruding tongue (HP:0010808)2.27294878
54Broad foot (HP:0001769)2.25240439
55Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.24775988
56Abnormality of the ischium (HP:0003174)2.23992522
57Abnormality of the 4th metacarpal (HP:0010012)2.23219264
58Abnormality of the diencephalon (HP:0010662)2.23092389
59Pancreatic fibrosis (HP:0100732)2.21215428
60Postaxial hand polydactyly (HP:0001162)2.21192121
61Adactyly (HP:0009776)2.21002056
62Volvulus (HP:0002580)2.20314311
63Renal hypoplasia (HP:0000089)2.17636783
64Rib fusion (HP:0000902)2.17267950
65Midline defect of the nose (HP:0004122)2.13709745
66Preaxial foot polydactyly (HP:0001841)2.13686497
67Severe Myopia (HP:0011003)2.13270403
68Obsessive-compulsive behavior (HP:0000722)2.12597724
69Abnormal auditory evoked potentials (HP:0006958)2.12434681
70Optic nerve hypoplasia (HP:0000609)2.11462398
71Febrile seizures (HP:0002373)2.10916320
72Fibular hypoplasia (HP:0003038)2.08259316
73Aplasia/Hypoplasia of the tibia (HP:0005772)2.05267249
74Esophageal atresia (HP:0002032)2.05225315
75Dysdiadochokinesis (HP:0002075)2.03979390
76Bile duct proliferation (HP:0001408)2.03868661
77Abnormal biliary tract physiology (HP:0012439)2.03868661
78Hyperglycinemia (HP:0002154)2.03338246
79Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.02996666
80Aplasia/Hypoplasia of the nipples (HP:0006709)2.02723905
81Narrow nasal bridge (HP:0000446)2.01890859
82Drooling (HP:0002307)2.01685331
83Excessive salivation (HP:0003781)2.01685331
84Gastroesophageal reflux (HP:0002020)2.01283332
85Hemivertebrae (HP:0002937)1.99417086
86Neurofibrillary tangles (HP:0002185)1.97799705
87Absent septum pellucidum (HP:0001331)1.96822212
88Abnormality of the antihelix (HP:0009738)1.96578195
89Visual hallucinations (HP:0002367)1.93981278
90Poor coordination (HP:0002370)1.93834200
91Specific learning disability (HP:0001328)1.93821728
92Pancreatic cysts (HP:0001737)1.92419740
93White forelock (HP:0002211)1.92417864
94Aplasia involving forearm bones (HP:0009822)1.92214069
95Absent forearm bone (HP:0003953)1.92214069
96Postaxial foot polydactyly (HP:0001830)1.92113314
97Anophthalmia (HP:0000528)1.91729919
98Alacrima (HP:0000522)1.91217158
99Hypoplastic left heart (HP:0004383)1.90204947
100Abnormality of the septum pellucidum (HP:0007375)1.89683894
101Dysmetria (HP:0001310)1.89455939
102Round ear (HP:0100830)1.88306824
103Pachygyria (HP:0001302)1.87469026
104Facial hemangioma (HP:0000329)1.86039502
105Mixed hearing impairment (HP:0000410)1.86025561
106Atonic seizures (HP:0010819)1.84255707
107Hypoplastic nipples (HP:0002557)1.83712663
108Abnormality of glycine metabolism (HP:0010895)1.83138803
109Abnormality of serine family amino acid metabolism (HP:0010894)1.83138803
110Preaxial hand polydactyly (HP:0001177)1.83015823
111Abnormality of the middle phalanges of the toes (HP:0010183)1.83004973
112Coronal craniosynostosis (HP:0004440)1.82626511
113Abnormality of midbrain morphology (HP:0002418)1.82317805
114Molar tooth sign on MRI (HP:0002419)1.82317805
115Increased corneal curvature (HP:0100692)1.82055707
116Keratoconus (HP:0000563)1.82055707
117Supranuclear gaze palsy (HP:0000605)1.80518332
118Lower limb muscle weakness (HP:0007340)1.79044159
119Cutaneous syndactyly (HP:0012725)1.78509483
120Renal dysplasia (HP:0000110)1.77846831
121Leiomyosarcoma (HP:0100243)1.77398641
122Uterine leiomyosarcoma (HP:0002891)1.77398641
123Long nose (HP:0003189)1.76642684
124Urinary urgency (HP:0000012)1.76438606
125Short tibia (HP:0005736)1.75867536
126Hyperglycinuria (HP:0003108)1.75807481
127Cortical dysplasia (HP:0002539)1.75790260
128Subacute progressive viral hepatitis (HP:0006572)1.75726286
129Urinary bladder sphincter dysfunction (HP:0002839)1.74963980
130Hamartoma (HP:0010566)1.74934856
131Morphological abnormality of the middle ear (HP:0008609)1.74776349
132Broad-based gait (HP:0002136)1.74591999
133Nephronophthisis (HP:0000090)1.72395648
134Aplasia/Hypoplasia of the fibula (HP:0006492)1.71945898
135Depression (HP:0000716)1.71578228
136Sclerocornea (HP:0000647)1.71570019
137Insomnia (HP:0100785)1.70861096
138Ankle clonus (HP:0011448)1.70183696
139Type II lissencephaly (HP:0007260)1.70169763
140Abnormality of the metopic suture (HP:0005556)1.69683198
141Overriding aorta (HP:0002623)1.69662273
142Supernumerary spleens (HP:0009799)1.67488381
143Aplasia/Hypoplasia of the tongue (HP:0010295)1.67123586
144Cutaneous finger syndactyly (HP:0010554)1.66628417
145Gait imbalance (HP:0002141)1.66099392
146Decreased lacrimation (HP:0000633)1.65492834
147Myelomeningocele (HP:0002475)1.65328211
148Patchy hypopigmentation of hair (HP:0011365)1.64412770
149Elfin facies (HP:0004428)1.64200930
150Truncal ataxia (HP:0002078)1.63034508
151Generalized tonic-clonic seizures (HP:0002069)1.61406151
152Gait ataxia (HP:0002066)1.60716066
153Short 4th metacarpal (HP:0010044)1.60612511
154Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.60612511
155Widely spaced teeth (HP:0000687)1.60401643
156Impaired vibration sensation in the lower limbs (HP:0002166)1.59612561
157Absent speech (HP:0001344)1.59275696
158Neonatal short-limb short stature (HP:0008921)1.59011982
159Symphalangism affecting the phalanges of the hand (HP:0009773)1.56742664
160Aplasia cutis congenita (HP:0001057)1.56620313
161True hermaphroditism (HP:0010459)1.56075437
162Abnormal eating behavior (HP:0100738)1.56001045

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK24.97093729
2CASK4.18864068
3TNIK4.04261573
4MARK13.10352591
5NTRK32.72934112
6PRKD32.59186406
7PHKG12.47143393
8PHKG22.47143393
9EPHA42.33890791
10NEK12.26616279
11PDGFRA2.20682271
12MAPK132.17660375
13WNK31.93439751
14MAP3K41.90621664
15DYRK21.85523917
16LMTK21.84041833
17MAP3K121.73281918
18MAP2K71.66051879
19PAK61.63795841
20EPHB21.61184892
21STK381.57600891
22MUSK1.52253756
23MKNK11.44022932
24CSNK1G21.43865152
25BMPR1B1.43644785
26FRK1.42999047
27NEK61.38615319
28MINK11.36608242
29MAP2K41.34932104
30TYRO31.34694424
31CSNK1A1L1.29098884
32MAPK151.27573209
33WEE11.26473795
34CSNK1G31.23965204
35SIK11.23665735
36BCR1.21882682
37FER1.16497216
38CAMKK11.15781276
39NUAK11.14689105
40CSNK1G11.13932503
41MKNK21.12572848
42YES11.11382130
43CDK51.11311443
44PTK61.09023990
45SGK21.08706797
46MAP4K21.06506846
47PAK31.06070428
48CAMK1G1.05159324
49ERBB21.01701025
50MAP3K91.00630109
51STK38L0.98867811
52KSR10.98673034
53CCNB10.96009102
54FGR0.92324922
55PRKCG0.91490343
56SGK4940.91335348
57SGK2230.91335348
58NTRK10.84862119
59TSSK60.84222050
60SGK30.82006811
61PBK0.81615553
62PDGFRB0.81528726
63ERBB40.80771053
64EPHA30.79715263
65CAMK2A0.79674392
66PRKCH0.79260746
67STK110.79086281
68DYRK1A0.77625665
69PKN10.74935648
70FES0.74563443
71RAF10.72974795
72CAMK2G0.71902032
73PNCK0.71159930
74ICK0.70348666
75DMPK0.69934447
76ERBB30.68492078
77PRKD20.68144252
78FGFR20.67086804
79DDR20.65287936
80PRPF4B0.64818933
81RPS6KA40.64671101
82SGK10.64629423
83CAMK2B0.64103373
84SRPK10.64089476
85PRKCE0.61094640
86NEK90.59671844
87CAMK1D0.59553832
88PINK10.59453639
89KSR20.58881846
90DYRK30.58763501
91ROCK10.58155394
92CDC42BPA0.56121128
93DAPK20.55969433
94BMX0.55484762
95FGFR10.55351460
96ROCK20.55267604
97CDK30.54698328
98MARK20.53569881
99CAMK2D0.52715598
100PLK40.52078366
101SIK20.51980991
102CSNK1D0.51958202
103PRKD10.51586088
104FYN0.51268925
105STK390.51141503
106RPS6KA30.51010297
107CDK150.50343368
108STK240.49844679
109MAP3K70.48805056
110CDC70.48508504
111PLK20.48371719
112CDK180.48016318
113RET0.47258159
114PRKCZ0.46606278
115UHMK10.45816337
116RIPK10.45812829
117SRC0.45570130
118AKT20.43910713
119CDK11A0.43587857
120MAPK100.42447961
121PRKDC0.40789947
122PRKAA20.40120312
123PRKACB0.39236215
124CAMK10.38965010
125GSK3A0.38878054
126CSNK1A10.38668864
127IGF1R0.38644629
128CDK140.38425545
129INSRR0.38178374
130TAF10.37747965
131CDK60.37388746
132PLK30.36906937
133PRKG10.36331438
134ATM0.35010584
135PRKACA0.32688942
136NLK0.31680834
137VRK10.28363663
138GSK3B0.28171815
139TGFBR10.25792269
140MAPK70.25373352

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.71909739
2Nitrogen metabolism_Homo sapiens_hsa009103.28068962
3GABAergic synapse_Homo sapiens_hsa047272.58689310
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.51275143
5Glutamatergic synapse_Homo sapiens_hsa047242.47162235
6Circadian entrainment_Homo sapiens_hsa047132.40732035
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.25597034
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.22501990
9Propanoate metabolism_Homo sapiens_hsa006402.18467351
10Morphine addiction_Homo sapiens_hsa050322.15354022
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.93775603
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93712007
13Insulin secretion_Homo sapiens_hsa049111.92886463
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.90059083
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.81950124
16Salivary secretion_Homo sapiens_hsa049701.76310279
17Olfactory transduction_Homo sapiens_hsa047401.74662944
18Renin secretion_Homo sapiens_hsa049241.71203783
19Long-term potentiation_Homo sapiens_hsa047201.69336959
20Fatty acid biosynthesis_Homo sapiens_hsa000611.63097494
21Gap junction_Homo sapiens_hsa045401.61349422
22Gastric acid secretion_Homo sapiens_hsa049711.59564407
23Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.59545970
24Vitamin B6 metabolism_Homo sapiens_hsa007501.52828919
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.49602111
26Amphetamine addiction_Homo sapiens_hsa050311.49343913
27Calcium signaling pathway_Homo sapiens_hsa040201.47117807
28Axon guidance_Homo sapiens_hsa043601.46174317
29Long-term depression_Homo sapiens_hsa047301.43213177
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.38241661
31Dopaminergic synapse_Homo sapiens_hsa047281.35236858
32Synaptic vesicle cycle_Homo sapiens_hsa047211.34660062
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.33786702
34Cocaine addiction_Homo sapiens_hsa050301.32873409
35Basal cell carcinoma_Homo sapiens_hsa052171.31684086
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29025681
37Cholinergic synapse_Homo sapiens_hsa047251.28647933
38Serotonergic synapse_Homo sapiens_hsa047261.28539898
39Melanogenesis_Homo sapiens_hsa049161.27536951
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.25547773
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25116369
42Dorso-ventral axis formation_Homo sapiens_hsa043201.23462043
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23335305
44Glioma_Homo sapiens_hsa052141.22873951
45Taste transduction_Homo sapiens_hsa047421.21921944
46cAMP signaling pathway_Homo sapiens_hsa040241.21604185
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17513878
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16937086
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10204070
50Oxytocin signaling pathway_Homo sapiens_hsa049211.10192689
51GnRH signaling pathway_Homo sapiens_hsa049121.05385603
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02148314
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01710600
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97072641
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.95510542
56Hedgehog signaling pathway_Homo sapiens_hsa043400.94525003
57beta-Alanine metabolism_Homo sapiens_hsa004100.93339008
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93103459
59ErbB signaling pathway_Homo sapiens_hsa040120.91978440
60Dilated cardiomyopathy_Homo sapiens_hsa054140.91276884
61Notch signaling pathway_Homo sapiens_hsa043300.89973162
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88920533
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87728737
64Estrogen signaling pathway_Homo sapiens_hsa049150.87584715
65Bile secretion_Homo sapiens_hsa049760.86512256
66Wnt signaling pathway_Homo sapiens_hsa043100.86501123
67Fatty acid metabolism_Homo sapiens_hsa012120.85119880
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82742470
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81877117
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81586760
71Histidine metabolism_Homo sapiens_hsa003400.81556286
72Type II diabetes mellitus_Homo sapiens_hsa049300.81534511
73Arginine biosynthesis_Homo sapiens_hsa002200.81505388
74Endometrial cancer_Homo sapiens_hsa052130.80713220
75Phototransduction_Homo sapiens_hsa047440.80518113
76Choline metabolism in cancer_Homo sapiens_hsa052310.80323435
77Pancreatic secretion_Homo sapiens_hsa049720.76572366
78Fatty acid degradation_Homo sapiens_hsa000710.73819601
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73609508
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.70462823
81Rap1 signaling pathway_Homo sapiens_hsa040150.68300744
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66885690
83Peroxisome_Homo sapiens_hsa041460.66440965
84Circadian rhythm_Homo sapiens_hsa047100.66343413
85Glycerolipid metabolism_Homo sapiens_hsa005610.63909444
86Melanoma_Homo sapiens_hsa052180.62833289
87Hippo signaling pathway_Homo sapiens_hsa043900.62485905
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.61540504
89Fanconi anemia pathway_Homo sapiens_hsa034600.61216859
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61140100
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60781875
92Thyroid hormone synthesis_Homo sapiens_hsa049180.57531739
93Lysine degradation_Homo sapiens_hsa003100.57119583
94Ras signaling pathway_Homo sapiens_hsa040140.56694756
95Basal transcription factors_Homo sapiens_hsa030220.53039873
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52884817
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49822736
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49347343
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.48996095
100Oocyte meiosis_Homo sapiens_hsa041140.48607864
101MicroRNAs in cancer_Homo sapiens_hsa052060.48316072
102MAPK signaling pathway_Homo sapiens_hsa040100.48267585
103Ether lipid metabolism_Homo sapiens_hsa005650.48164991
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.46648978
105Cardiac muscle contraction_Homo sapiens_hsa042600.46376988
106TGF-beta signaling pathway_Homo sapiens_hsa043500.44681790
107Adherens junction_Homo sapiens_hsa045200.44475534
108Colorectal cancer_Homo sapiens_hsa052100.44453205
109Renal cell carcinoma_Homo sapiens_hsa052110.43984176
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41326390
111Tryptophan metabolism_Homo sapiens_hsa003800.39976663
112Focal adhesion_Homo sapiens_hsa045100.38406023
113Glucagon signaling pathway_Homo sapiens_hsa049220.38359320
114Steroid biosynthesis_Homo sapiens_hsa001000.38162087
115Butanoate metabolism_Homo sapiens_hsa006500.37949705
116Arginine and proline metabolism_Homo sapiens_hsa003300.37803647
117Tight junction_Homo sapiens_hsa045300.36416782
118PPAR signaling pathway_Homo sapiens_hsa033200.36067987
119ECM-receptor interaction_Homo sapiens_hsa045120.35072846
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34998492
121Prion diseases_Homo sapiens_hsa050200.34887992
122Fatty acid elongation_Homo sapiens_hsa000620.34779112
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34110023
124Prostate cancer_Homo sapiens_hsa052150.32534200

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