PTPRU

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)4.74243351
2epithelial cell-cell adhesion (GO:0090136)4.73296802
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.63035494
4regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.59068849
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.58685889
6vocalization behavior (GO:0071625)4.48520455
7synaptic vesicle exocytosis (GO:0016079)4.39004449
8layer formation in cerebral cortex (GO:0021819)4.29965637
9desmosome organization (GO:0002934)4.24073591
10hemidesmosome assembly (GO:0031581)4.19974096
11synaptic vesicle maturation (GO:0016188)4.18638789
12Golgi transport vesicle coating (GO:0048200)4.05096176
13COPI coating of Golgi vesicle (GO:0048205)4.05096176
14dendritic spine morphogenesis (GO:0060997)4.03196443
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.00676942
16lung epithelium development (GO:0060428)3.89772032
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.86967073
18synaptic vesicle endocytosis (GO:0048488)3.75261348
19glutamate secretion (GO:0014047)3.74942134
20synaptic vesicle docking involved in exocytosis (GO:0016081)3.66731544
21exploration behavior (GO:0035640)3.64406921
22regulation of glutamate receptor signaling pathway (GO:1900449)3.63383265
23regulation of synaptic vesicle exocytosis (GO:2000300)3.58377548
24axonemal dynein complex assembly (GO:0070286)3.58323698
25paraxial mesoderm development (GO:0048339)3.56977876
26Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.54974419
27semaphorin-plexin signaling pathway (GO:0071526)3.49289849
28regulation of neuronal synaptic plasticity (GO:0048168)3.47775112
29dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.47603845
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.42757229
31adherens junction assembly (GO:0034333)3.41364659
32neuron cell-cell adhesion (GO:0007158)3.40466373
33positive regulation of dendritic spine morphogenesis (GO:0061003)3.38644600
34neuron recognition (GO:0008038)3.37513833
35ionotropic glutamate receptor signaling pathway (GO:0035235)3.36256246
36protein retention in ER lumen (GO:0006621)3.35635998
37axonal fasciculation (GO:0007413)3.35382580
38regulation of establishment of planar polarity (GO:0090175)3.35230953
39activation of protein kinase A activity (GO:0034199)3.32338655
40maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.29391037
41establishment of planar polarity (GO:0001736)3.28409642
42establishment of tissue polarity (GO:0007164)3.28409642
43basement membrane organization (GO:0071711)3.27535000
44neurotransmitter secretion (GO:0007269)3.22092410
45positive regulation of synapse maturation (GO:0090129)3.20161395
46notochord development (GO:0030903)3.20152589
47neuromuscular process controlling balance (GO:0050885)3.18169371
48dendritic spine organization (GO:0097061)3.17669211
49cell-substrate junction assembly (GO:0007044)3.17239428
50protein localization to synapse (GO:0035418)3.16240781
51proline transport (GO:0015824)3.15971739
52apoptotic process involved in morphogenesis (GO:0060561)3.14187992
53cell migration in hindbrain (GO:0021535)3.10615994
54regulation of synaptic vesicle transport (GO:1902803)3.08996476
55cell-substrate adherens junction assembly (GO:0007045)3.08502951
56focal adhesion assembly (GO:0048041)3.08502951
57neuronal action potential propagation (GO:0019227)3.07312420
58non-canonical Wnt signaling pathway (GO:0035567)3.06864519
59regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.06355844
60retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.05418507
61innervation (GO:0060384)3.05148158
62signal complex assembly (GO:0007172)3.02590019
63glutamate receptor signaling pathway (GO:0007215)3.02342409
64motile cilium assembly (GO:0044458)2.99413872
65neuromuscular process controlling posture (GO:0050884)2.97754755
66regulation of dendritic spine morphogenesis (GO:0061001)2.96748709
67bundle of His cell to Purkinje myocyte communication (GO:0086069)2.96656247
68cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.95881093
69vitamin transmembrane transport (GO:0035461)2.94082905
70regulation of mammary gland epithelial cell proliferation (GO:0033599)2.94072826
71regulation of synapse structural plasticity (GO:0051823)2.93644895
72neuronal ion channel clustering (GO:0045161)2.93492314
73establishment or maintenance of bipolar cell polarity (GO:0061245)2.91659396
74establishment or maintenance of apical/basal cell polarity (GO:0035088)2.91659396
75synaptic transmission, glutamatergic (GO:0035249)2.91082841
76regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.91071125
77auditory behavior (GO:0031223)2.91013777
78branching involved in salivary gland morphogenesis (GO:0060445)2.89998093
79mating behavior (GO:0007617)2.89441825
80establishment of apical/basal cell polarity (GO:0035089)2.88418593
81proline metabolic process (GO:0006560)2.86964933
82protein localization to endosome (GO:0036010)2.86785273
83cell communication by electrical coupling (GO:0010644)2.85309280
84glomerular epithelial cell development (GO:0072310)2.80142921
85sodium ion export (GO:0071436)2.78155888
86positive regulation of pseudopodium assembly (GO:0031274)2.77923109
87dendrite morphogenesis (GO:0048813)2.77485447
88lens fiber cell development (GO:0070307)2.76489139
89cellular potassium ion homeostasis (GO:0030007)2.76482806
90activation of Rac GTPase activity (GO:0032863)2.76179942
91maternal placenta development (GO:0001893)2.75908872
92negative regulation of chondrocyte differentiation (GO:0032331)2.75540164
93positive regulation of smoothened signaling pathway (GO:0045880)2.75537682
94long-term memory (GO:0007616)2.74346662
95regulation of excitatory postsynaptic membrane potential (GO:0060079)2.73650575
96apical protein localization (GO:0045176)2.73378755
97cerebellar Purkinje cell layer development (GO:0021680)2.73153008
98lens development in camera-type eye (GO:0002088)2.71198524
99positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.70879838
100craniofacial suture morphogenesis (GO:0097094)2.70827408
101G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.70743369
102regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.70065818
103regulation of cardioblast differentiation (GO:0051890)2.69976217
104regulation of cAMP-dependent protein kinase activity (GO:2000479)2.69955262
105cerebellar Purkinje cell differentiation (GO:0021702)2.69644713
106cell-cell junction maintenance (GO:0045217)2.69592401
107cytoskeletal anchoring at plasma membrane (GO:0007016)2.69564755
108establishment or maintenance of monopolar cell polarity (GO:0061339)2.68670040
109establishment of monopolar cell polarity (GO:0061162)2.68670040
110gamma-aminobutyric acid transport (GO:0015812)2.68022444
111positive regulation of dendritic spine development (GO:0060999)2.67206974
112lateral sprouting from an epithelium (GO:0060601)2.67021497
113establishment of nucleus localization (GO:0040023)2.66001261
1144-hydroxyproline metabolic process (GO:0019471)2.65252909
115neuron-neuron synaptic transmission (GO:0007270)2.64978378
116regulation of synaptic plasticity (GO:0048167)2.64742517
117regulation of translational fidelity (GO:0006450)2.64442899
118regulation of postsynaptic membrane potential (GO:0060078)2.62676451
119neurotransmitter transport (GO:0006836)2.62210496
120neuromuscular process (GO:0050905)2.62133966
121cochlea morphogenesis (GO:0090103)2.61845287
122mitotic G1 DNA damage checkpoint (GO:0031571)2.60183174
123cochlea development (GO:0090102)2.59098395
124regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.58927291
125central nervous system projection neuron axonogenesis (GO:0021952)2.57404684
126regulation of respiratory system process (GO:0044065)2.55457037
127postsynaptic membrane organization (GO:0001941)2.52643044
128positive regulation of membrane potential (GO:0045838)2.52630682
129gap junction assembly (GO:0016264)2.51623149
130regulation of pseudopodium assembly (GO:0031272)2.51466984
131positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.50228133
132synapse organization (GO:0050808)2.49913332
133establishment of synaptic vesicle localization (GO:0097480)2.49680213
134synaptic vesicle transport (GO:0048489)2.49680213
135chemosensory behavior (GO:0007635)2.48940005
136synapse assembly (GO:0007416)2.48083867
137polarized epithelial cell differentiation (GO:0030859)2.47772976
138protein complex localization (GO:0031503)2.47650403
139asymmetric protein localization (GO:0008105)2.46909244
140hippo signaling (GO:0035329)2.44851945
141skin morphogenesis (GO:0043589)2.43793230
142transmission of nerve impulse (GO:0019226)2.43318924
143membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.42886043
144developmental programmed cell death (GO:0010623)2.39737663
145camera-type eye morphogenesis (GO:0048593)2.38875534
146convergent extension (GO:0060026)2.38515742
147G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.37889871
148positive regulation of synaptic transmission, GABAergic (GO:0032230)2.37742029
149proline biosynthetic process (GO:0006561)2.37550262
150regulation of neurotransmitter levels (GO:0001505)2.37378443
151regulation of synapse maturation (GO:0090128)2.37147020
152left/right pattern formation (GO:0060972)2.37004412
153negative regulation of catenin import into nucleus (GO:0035414)2.35686751
154glomerular basement membrane development (GO:0032836)2.35451646
155barbed-end actin filament capping (GO:0051016)2.35399492
156cellular sodium ion homeostasis (GO:0006883)2.34697739
157surfactant homeostasis (GO:0043129)2.34663258
158planar cell polarity pathway involved in neural tube closure (GO:0090179)2.33846008
159regulation of vesicle fusion (GO:0031338)2.33511425
160morphogenesis of embryonic epithelium (GO:0016331)2.33495416
161endothelial cell morphogenesis (GO:0001886)2.32984046
162histone arginine methylation (GO:0034969)2.32936772
163regulation of calcium ion-dependent exocytosis (GO:0017158)2.31859342
164somatic stem cell division (GO:0048103)2.31776191
165neurotransmitter-gated ion channel clustering (GO:0072578)2.31620518
166response to auditory stimulus (GO:0010996)2.31178929
167regulation of axon extension involved in axon guidance (GO:0048841)2.30056690
168vesicle transport along microtubule (GO:0047496)2.29867748
169long-term synaptic potentiation (GO:0060291)2.29582984
170regulation of cholesterol homeostasis (GO:2000188)2.29571133
171dopamine biosynthetic process (GO:0042416)2.29544803
172muscle cell migration (GO:0014812)2.29305935
173renal system development (GO:0072001)2.28407682
174cellular protein complex localization (GO:0034629)2.28336431
175mitotic G1/S transition checkpoint (GO:0044819)2.27725450
176apoptotic process involved in development (GO:1902742)2.27555832
177lung-associated mesenchyme development (GO:0060484)2.26765389
178peptidyl-proline hydroxylation (GO:0019511)2.26642087
179body morphogenesis (GO:0010171)2.25980639
180G1 DNA damage checkpoint (GO:0044783)2.25819817
181negative regulation of cell fate specification (GO:0009996)2.24900135
182embryonic camera-type eye development (GO:0031076)2.24117173
183peptidyl-arginine omega-N-methylation (GO:0035247)2.24062450
184regulation of catenin import into nucleus (GO:0035412)2.23479954
185cilium or flagellum-dependent cell motility (GO:0001539)2.22947649
186cranial suture morphogenesis (GO:0060363)2.20162915
187branching involved in mammary gland duct morphogenesis (GO:0060444)2.19711860
188regulation of cholesterol biosynthetic process (GO:0045540)2.17891425
189eye morphogenesis (GO:0048592)2.17649872
190negative regulation of cell size (GO:0045792)2.15299441
191neural tube development (GO:0021915)2.15026031

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.74337870
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.81807516
3RARG_19884340_ChIP-ChIP_MEFs_Mouse2.95670127
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70839952
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69480762
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.67359370
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63725671
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63725671
9* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.56831406
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55778047
11ERG_21242973_ChIP-ChIP_JURKAT_Human2.50820775
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44310944
13* RACK7_27058665_Chip-Seq_MCF-7_Human2.42506419
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.35489401
15DROSHA_22980978_ChIP-Seq_HELA_Human2.33436364
16RNF2_27304074_Chip-Seq_ESCs_Mouse2.30950987
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28915658
18* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27150821
19* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24776578
20* EED_16625203_ChIP-ChIP_MESCs_Mouse2.22488456
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.18753103
22* REST_21632747_ChIP-Seq_MESCs_Mouse2.16182665
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15831732
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14913422
25* EZH2_27294783_Chip-Seq_ESCs_Mouse2.10687226
26RARB_27405468_Chip-Seq_BRAIN_Mouse2.08854694
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04543901
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.02938673
29CLOCK_20551151_ChIP-Seq_293T_Human2.00449050
30* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.98422029
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.95036981
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.88152420
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.87020975
34* REST_18959480_ChIP-ChIP_MESCs_Mouse1.85350835
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.83205612
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.82826149
37* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.81634204
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79237471
39* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.78387026
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77170060
41* KDM2B_26808549_Chip-Seq_K562_Human1.76498289
42* RING1B_27294783_Chip-Seq_NPCs_Mouse1.74788660
43* RING1B_27294783_Chip-Seq_ESCs_Mouse1.73578380
44* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.73477270
45GBX2_23144817_ChIP-Seq_PC3_Human1.71776417
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.69748957
47* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.68117960
48* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65443304
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.64460923
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.63561034
51ZFP281_27345836_Chip-Seq_ESCs_Mouse1.63549870
52ZNF274_21170338_ChIP-Seq_K562_Hela1.58315798
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57302150
54P300_27058665_Chip-Seq_ZR-75-30cells_Human1.55319999
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.55244099
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.51998732
57TRIM28_21343339_ChIP-Seq_HEK293_Human1.51019384
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50850285
59RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.50008098
60* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48328365
61SMC4_20622854_ChIP-Seq_HELA_Human1.46176995
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.46160895
63* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.43944645
64RUNX1_27514584_Chip-Seq_MCF-7_Human1.42227118
65ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.41455435
66* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.41340122
67* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.40343065
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40254612
69* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39986703
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.39623571
71TP53_22127205_ChIP-Seq_IMR90_Human1.38704131
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38670618
73TET1_21451524_ChIP-Seq_MESCs_Mouse1.37211382
74P68_20966046_ChIP-Seq_HELA_Human1.34369309
75* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33891511
76ATF3_27146783_Chip-Seq_COLON_Human1.33805928
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32394486
78* LXR_22292898_ChIP-Seq_THP-1_Human1.31497426
79* TP53_20018659_ChIP-ChIP_R1E_Mouse1.31426445
80MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30963766
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30667025
82* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30395267
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30276909
84OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.29855308
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29445162
86KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28584190
87* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25597398
88DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25438370
89SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24690852
90* SA1_27219007_Chip-Seq_ERYTHROID_Human1.24453629
91* CTCF_27219007_Chip-Seq_Bcells_Human1.23476204
92* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21240340
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19358966
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17973326
95* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17914485
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16467325
97AR_19668381_ChIP-Seq_PC3_Human1.16111090
98AHR_22903824_ChIP-Seq_MCF-7_Human1.15250836
99* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14228059
100SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13799490
101* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13782585
102RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13756219
103AR_21572438_ChIP-Seq_LNCaP_Human1.13632142
104NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.12481097
105* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10948443
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10510887
107CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10323722
108KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09898396
109KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09898396
110KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09898396
111ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09071663
112* UBF1/2_26484160_Chip-Seq_HMECs_Human1.08975537
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08603986
114* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08516298
115EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07885104
116SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07632541
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07259393
118* KDM2B_26808549_Chip-Seq_JURKAT_Human1.07114606
119KAP1_27257070_Chip-Seq_ESCs_Mouse1.07056030
120NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05831524
121CBX2_27304074_Chip-Seq_ESCs_Mouse1.05487319
122SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05371723
123TCF7_22412390_ChIP-Seq_EML_Mouse1.05268779
124SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05050742
125SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04858191
126AR_21909140_ChIP-Seq_LNCAP_Human1.04722380
127TP63_22573176_ChIP-Seq_HFKS_Human1.04203885
128* SOX2_21211035_ChIP-Seq_LN229_Gbm1.04155879
129ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03911472
130STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03897550
131ARNT_22903824_ChIP-Seq_MCF-7_Human1.03752928
132CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03576441
133* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02983483
134SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01757896
135* TET1_21490601_ChIP-Seq_MESCs_Mouse1.00755467
136ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00268458
137ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00041166
138TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.99901070
139TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99535426
140BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99429923
141PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98256283
142ESR2_21235772_ChIP-Seq_MCF-7_Human0.97538038
143TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97171755
144* KDM2B_26808549_Chip-Seq_DND41_Human0.96256596
145CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95805151
146ISL1_27105846_Chip-Seq_CPCs_Mouse0.95345740
147TBX20_22080862_ChIP-Seq_HEART_Mouse0.94738279
148TBX20_22328084_ChIP-Seq_HEART_Mouse0.94738279
149TP53_23651856_ChIP-Seq_MEFs_Mouse0.94603671
150* SMAD3_21741376_ChIP-Seq_ESCs_Human0.94080991
151NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93906664
152CREB1_26743006_Chip-Seq_LNCaP_Human0.93840004
153TP63_17297297_ChIP-ChIP_HaCaT_Human0.93004734
154ESR1_20079471_ChIP-ChIP_T-47D_Human0.91260681
155NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91003898
156* SMAD4_21799915_ChIP-Seq_A2780_Human0.89601384
157* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87531121
158* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87000632
159POU5F1_16518401_ChIP-PET_MESCs_Mouse0.86489263
160PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.85520546
161GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84324029
162* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83941422
163* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83935268
164TBX3_20139965_ChIP-Seq_MESCs_Mouse0.83407630
165ZNF263_19887448_ChIP-Seq_K562_Human0.83219520
166CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82918066
167TBX3_20139965_ChIP-Seq_ESCs_Mouse0.82687586
168THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82548440
169NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.82302524

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.98054732
2MP0002877_abnormal_melanocyte_morpholog4.03002651
3MP0003705_abnormal_hypodermis_morpholog3.44355381
4MP0005257_abnormal_intraocular_pressure3.33390545
5MP0003283_abnormal_digestive_organ3.11022287
6MP0003880_abnormal_central_pattern2.98840676
7MP0003635_abnormal_synaptic_transmissio2.97792007
8MP0002063_abnormal_learning/memory/cond2.45218164
9MP0001188_hyperpigmentation2.41593748
10MP0008438_abnormal_cutaneous_collagen2.37914257
11MP0009780_abnormal_chondrocyte_physiolo2.23450790
12MP0001849_ear_inflammation2.20790075
13MP0000467_abnormal_esophagus_morphology2.20107812
14MP0003879_abnormal_hair_cell2.13757784
15MP0004270_analgesia2.12143832
16MP0005409_darkened_coat_color2.08151209
17MP0009745_abnormal_behavioral_response2.02259203
18MP0002572_abnormal_emotion/affect_behav1.99748277
19MP0002064_seizures1.99203601
20MP0003566_abnormal_cell_adhesion1.95839711
21MP0006072_abnormal_retinal_apoptosis1.91263998
22MP0000778_abnormal_nervous_system1.89734887
23MP0002909_abnormal_adrenal_gland1.85734136
24MP0001486_abnormal_startle_reflex1.82822794
25MP0002089_abnormal_postnatal_growth/wei1.81359526
26MP0010030_abnormal_orbit_morphology1.77269224
27MP0009046_muscle_twitch1.76809873
28MP0002653_abnormal_ependyma_morphology1.72429671
29MP0004264_abnormal_extraembryonic_tissu1.70074973
30MP0003122_maternal_imprinting1.63091429
31MP0002272_abnormal_nervous_system1.61343871
32MP0001348_abnormal_lacrimal_gland1.60518032
33MP0004233_abnormal_muscle_weight1.58884072
34MP0001299_abnormal_eye_distance/1.58136675
35MP0004858_abnormal_nervous_system1.56629261
36MP0002697_abnormal_eye_size1.56617376
37MP0001485_abnormal_pinna_reflex1.56209140
38MP0004885_abnormal_endolymph1.54561084
39MP0002796_impaired_skin_barrier1.53760490
40MP0002184_abnormal_innervation1.53122118
41MP0003119_abnormal_digestive_system1.52447233
42MP0005248_abnormal_Harderian_gland1.52153823
43MP0000762_abnormal_tongue_morphology1.51717722
44MP0003453_abnormal_keratinocyte_physiol1.48712357
45MP0002234_abnormal_pharynx_morphology1.48367379
46MP0002734_abnormal_mechanical_nocicepti1.47582315
47MP0001501_abnormal_sleep_pattern1.45853877
48MP0000955_abnormal_spinal_cord1.42504536
49MP0000678_abnormal_parathyroid_gland1.40774825
50MP0002098_abnormal_vibrissa_morphology1.40676427
51MP0002249_abnormal_larynx_morphology1.39720187
52MP0001346_abnormal_lacrimal_gland1.38890910
53MP0002060_abnormal_skin_morphology1.38818531
54MP0002733_abnormal_thermal_nociception1.37877562
55MP0000537_abnormal_urethra_morphology1.36658823
56MP0005423_abnormal_somatic_nervous1.36605058
57MP0004811_abnormal_neuron_physiology1.36278193
58MP0001968_abnormal_touch/_nociception1.30670830
59MP0005167_abnormal_blood-brain_barrier1.30364904
60MP0000534_abnormal_ureter_morphology1.29798664
61MP0000566_synostosis1.29273232
62MP0010234_abnormal_vibrissa_follicle1.27250498
63MP0003787_abnormal_imprinting1.24613535
64MP0002882_abnormal_neuron_morphology1.23225389
65MP0006292_abnormal_olfactory_placode1.23020761
66MP0001970_abnormal_pain_threshold1.21385903
67MP0002557_abnormal_social/conspecific_i1.21297028
68MP0003890_abnormal_embryonic-extraembry1.20768256
69MP0004272_abnormal_basement_membrane1.20690610
70MP0003941_abnormal_skin_development1.20326970
71MP0005187_abnormal_penis_morphology1.19720329
72MP0002067_abnormal_sensory_capabilities1.18904066
73MP0000631_abnormal_neuroendocrine_gland1.18068999
74MP0005253_abnormal_eye_physiology1.17200734
75MP0000049_abnormal_middle_ear1.17115090
76MP0009672_abnormal_birth_weight1.15152563
77MP0000026_abnormal_inner_ear1.14452776
78MP0005501_abnormal_skin_physiology1.12354899
79MP0002938_white_spotting1.11568998
80MP0001502_abnormal_circadian_rhythm1.11346693
81MP0008569_lethality_at_weaning1.10628722
82MP0005645_abnormal_hypothalamus_physiol1.10438545
83MP0000013_abnormal_adipose_tissue1.10356602
84MP0005451_abnormal_body_composition1.09977543
85MP0000462_abnormal_digestive_system1.09718609
86MP0002822_catalepsy1.09433635
87MP0001440_abnormal_grooming_behavior1.08682190
88MP0002152_abnormal_brain_morphology1.08515127
89MP0005394_taste/olfaction_phenotype1.07604987
90MP0005499_abnormal_olfactory_system1.07604987
91MP0004145_abnormal_muscle_electrophysio1.07428669
92MP0000733_abnormal_muscle_development1.06566411
93MP0004133_heterotaxia1.05743709
94MP0003937_abnormal_limbs/digits/tail_de1.04327191
95MP0002735_abnormal_chemical_nociception1.03922177
96MP0000428_abnormal_craniofacial_morphol1.03633569
97MP0002066_abnormal_motor_capabilities/c1.03578815
98MP0005503_abnormal_tendon_morphology1.03346771
99MP0001963_abnormal_hearing_physiology1.02807221
100MP0003942_abnormal_urinary_system1.02759303
101MP0005408_hypopigmentation1.02069774
102MP0005023_abnormal_wound_healing1.00710917
103MP0000003_abnormal_adipose_tissue1.00641405
104MP0005058_abnormal_lysosome_morphology1.00574304
105MP0003115_abnormal_respiratory_system0.99789430
106MP0004924_abnormal_behavior0.98859111
107MP0005386_behavior/neurological_phenoty0.98859111
108MP0005377_hearing/vestibular/ear_phenot0.98260332
109MP0003878_abnormal_ear_physiology0.98260332
110MP0002092_abnormal_eye_morphology0.98181778
111MP0006276_abnormal_autonomic_nervous0.94053370
112MP0003861_abnormal_nervous_system0.93931520
113MP0002282_abnormal_trachea_morphology0.93496260
114MP0005646_abnormal_pituitary_gland0.92985037
115MP0008932_abnormal_embryonic_tissue0.91224070
116MP0005197_abnormal_uvea_morphology0.91209923
117MP0004147_increased_porphyrin_level0.90658154
118MP0005623_abnormal_meninges_morphology0.90376381
119MP0002085_abnormal_embryonic_tissue0.89513740
120MP0002084_abnormal_developmental_patter0.89408970
121MP0010678_abnormal_skin_adnexa0.89228133
122MP0008961_abnormal_basal_metabolism0.88722581
123MP0005171_absent_coat_pigmentation0.88070709
124MP0003633_abnormal_nervous_system0.87903986
125MP0001270_distended_abdomen0.87649957
126MP0005275_abnormal_skin_tensile0.87375837
127MP0008260_abnormal_autophagy0.86856192
128MP0009053_abnormal_anal_canal0.85992582
129MP0005508_abnormal_skeleton_morphology0.84859426
130MP0003329_amyloid_beta_deposits0.84575027
131MP0002736_abnormal_nociception_after0.84221692
132MP0000751_myopathy0.84171372
133MP0004782_abnormal_surfactant_physiolog0.83574000
134MP0000432_abnormal_head_morphology0.83186365
135MP0003385_abnormal_body_wall0.83131003
136MP0003935_abnormal_craniofacial_develop0.83127778
137MP0000579_abnormal_nail_morphology0.82603149
138MP0003136_yellow_coat_color0.81511413
139MP0002116_abnormal_craniofacial_bone0.81358956
140MP0001943_abnormal_respiration0.81025722
141MP0010352_gastrointestinal_tract_polyps0.80948125
142MP0000639_abnormal_adrenal_gland0.80427378
143MP0000377_abnormal_hair_follicle0.79493847
144MP0003123_paternal_imprinting0.79104754
145MP0002111_abnormal_tail_morphology0.78727726
146MP0008789_abnormal_olfactory_epithelium0.78714307
147MP0003755_abnormal_palate_morphology0.78600531
148MP0000516_abnormal_urinary_system0.78415423
149MP0005367_renal/urinary_system_phenotyp0.78415423
150MP0002108_abnormal_muscle_morphology0.78393634
151MP0002233_abnormal_nose_morphology0.78285614
152MP0005076_abnormal_cell_differentiation0.78260564
153MP0002896_abnormal_bone_mineralization0.77727270
154MP0001730_embryonic_growth_arrest0.77285035
155MP0004185_abnormal_adipocyte_glucose0.74399311
156MP0010630_abnormal_cardiac_muscle0.74246923
157MP0002932_abnormal_joint_morphology0.73585773
158MP0005380_embryogenesis_phenotype0.73515878
159MP0001672_abnormal_embryogenesis/_devel0.73515878
160MP0000383_abnormal_hair_follicle0.73466456
161MP0009384_cardiac_valve_regurgitation0.73308332
162MP0002075_abnormal_coat/hair_pigmentati0.73255569
163MP0010771_integument_phenotype0.72528808
164MP0003634_abnormal_glial_cell0.72272847
165MP0006138_congestive_heart_failure0.72063562
166MP0001958_emphysema0.70800823
167MP0003091_abnormal_cell_migration0.70383111

Predicted human phenotypes

RankGene SetZ-score
1Nuclear cataract (HP:0100018)6.55290773
2Zonular cataract (HP:0010920)5.34232847
3Myokymia (HP:0002411)3.75016636
4Premature rupture of membranes (HP:0001788)3.69131340
5Visual hallucinations (HP:0002367)3.67303616
6Focal motor seizures (HP:0011153)3.51862863
7Annular pancreas (HP:0001734)3.32060465
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.24847908
9Amblyopia (HP:0000646)3.24616173
10Protrusio acetabuli (HP:0003179)3.17699055
11Focal seizures (HP:0007359)3.00796619
12Ulnar bowing (HP:0003031)2.90377499
13White forelock (HP:0002211)2.86762693
14Distal upper limb amyotrophy (HP:0007149)2.80252441
15Upper limb amyotrophy (HP:0009129)2.80252441
16Turricephaly (HP:0000262)2.79202418
17Atonic seizures (HP:0010819)2.77325784
18Atrophic scars (HP:0001075)2.70725650
19Action tremor (HP:0002345)2.69010775
20Chronic bronchitis (HP:0004469)2.62602253
21Hand muscle atrophy (HP:0009130)2.61697719
22Pterygium (HP:0001059)2.61657113
23Shallow orbits (HP:0000586)2.60462807
24Right ventricular cardiomyopathy (HP:0011663)2.55467186
25Epileptic encephalopathy (HP:0200134)2.53943266
26Flat acetabular roof (HP:0003180)2.50838839
27Abnormal respiratory motile cilium physiology (HP:0012261)2.49062212
28Germ cell neoplasia (HP:0100728)2.48384184
29Progressive cerebellar ataxia (HP:0002073)2.48190143
30Natal tooth (HP:0000695)2.45177122
31Rhinitis (HP:0012384)2.44486301
32Abnormality of the distal phalanges of the toes (HP:0010182)2.43925636
33Abnormal respiratory motile cilium morphology (HP:0005938)2.43280717
34Abnormal respiratory epithelium morphology (HP:0012253)2.43280717
35Abnormality of the lower motor neuron (HP:0002366)2.40234099
36Coronal craniosynostosis (HP:0004440)2.39555894
37Advanced eruption of teeth (HP:0006288)2.38246933
38Absence seizures (HP:0002121)2.34726482
39Cervical subluxation (HP:0003308)2.32852480
40Patchy hypopigmentation of hair (HP:0011365)2.32293286
41Hypercortisolism (HP:0001578)2.31295258
42Fragile skin (HP:0001030)2.28510355
43Abnormal ciliary motility (HP:0012262)2.25577341
44Neoplasm of the heart (HP:0100544)2.23706204
45Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.23601561
46Rib fusion (HP:0000902)2.22343590
47Cerebral aneurysm (HP:0004944)2.21978972
48Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.21670384
49Febrile seizures (HP:0002373)2.18172879
50Insomnia (HP:0100785)2.18047567
51Abnormality of the salivary glands (HP:0010286)2.17758982
52Neonatal short-limb short stature (HP:0008921)2.16352184
53Heterochromia iridis (HP:0001100)2.16287676
54Abnormality of the aortic arch (HP:0012303)2.14424960
55Short nail (HP:0001799)2.14086969
56Distal lower limb muscle weakness (HP:0009053)2.12734128
57Alacrima (HP:0000522)2.11149215
58Facial hemangioma (HP:0000329)2.09164006
59Anteriorly placed anus (HP:0001545)2.08259839
60Limb dystonia (HP:0002451)2.07023003
61Abnormality of dentin (HP:0010299)2.04264492
62Abnormality of molar morphology (HP:0011070)2.02475205
63Abnormality of molar (HP:0011077)2.02475205
64Depression (HP:0000716)2.02244746
65Supranuclear gaze palsy (HP:0000605)2.02244680
66Generalized tonic-clonic seizures (HP:0002069)2.01861447
67Mildly elevated creatine phosphokinase (HP:0008180)2.01469431
68Dynein arm defect of respiratory motile cilia (HP:0012255)2.01418707
69Absent/shortened dynein arms (HP:0200106)2.01418707
70Intestinal atresia (HP:0011100)2.01341668
71Broad face (HP:0000283)2.01286976
72Partial duplication of thumb phalanx (HP:0009944)2.00218434
73Genetic anticipation (HP:0003743)1.99263349
74Selective tooth agenesis (HP:0001592)1.97876392
75Growth hormone excess (HP:0000845)1.96522590
76Thickened helices (HP:0000391)1.96519320
77Abnormality of permanent molar morphology (HP:0011071)1.96394370
78Abnormality of the dental root (HP:0006486)1.96394370
79Taurodontia (HP:0000679)1.96394370
80Atelectasis (HP:0100750)1.95968435
81Dialeptic seizures (HP:0011146)1.94608076
82Facial cleft (HP:0002006)1.93454227
83Increased connective tissue (HP:0009025)1.92048893
84Dysdiadochokinesis (HP:0002075)1.90058896
85Bell-shaped thorax (HP:0001591)1.89841334
86Hyperparathyroidism (HP:0000843)1.89182550
87Humeroradial synostosis (HP:0003041)1.88816842
88Synostosis involving the elbow (HP:0003938)1.88816842
89Fetal akinesia sequence (HP:0001989)1.88321049
90Bronchomalacia (HP:0002780)1.87661240
91Broad-based gait (HP:0002136)1.87548003
92Partial duplication of the phalanx of hand (HP:0009999)1.87265915
93Narrow nasal bridge (HP:0000446)1.86566722
94Postural tremor (HP:0002174)1.86323555
95Megalencephaly (HP:0001355)1.86234300
96Fragile nails (HP:0001808)1.85351260
97Hypoplastic nipples (HP:0002557)1.85210373
98Vertebral compression fractures (HP:0002953)1.83901338
99Stridor (HP:0010307)1.83612842
100Ankle clonus (HP:0011448)1.83388488
101Spinal rigidity (HP:0003306)1.83108015
102Nasal polyposis (HP:0100582)1.82837854
103Distal lower limb amyotrophy (HP:0008944)1.82210912
104Clumsiness (HP:0002312)1.82115228
105Congenital glaucoma (HP:0001087)1.81674332
106Vertebral arch anomaly (HP:0008438)1.81593429
107Achilles tendon contracture (HP:0001771)1.81254391
108Obstructive sleep apnea (HP:0002870)1.80498225
109Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.79576909
110Absent epiphyses (HP:0010577)1.79576909
111Hypoplasia of the capital femoral epiphysis (HP:0003090)1.79143491
112Agitation (HP:0000713)1.78982972
113Pheochromocytoma (HP:0002666)1.78814083
114Popliteal pterygium (HP:0009756)1.78269367
115Abnormality of the dental pulp (HP:0006479)1.77239226
116Hyperacusis (HP:0010780)1.76362323
117Renal duplication (HP:0000075)1.76351499
118Amelogenesis imperfecta (HP:0000705)1.76187403
119Concave nail (HP:0001598)1.75963336
120Shawl scrotum (HP:0000049)1.75612773
121Asymmetry of the thorax (HP:0001555)1.75234011
122Trismus (HP:0000211)1.75176168
123Pointed chin (HP:0000307)1.75124470
124Premature skin wrinkling (HP:0100678)1.74550630
125Ankle contracture (HP:0006466)1.73318662
126Abnormality of carpal bone ossification (HP:0006257)1.72037017
127Hamartoma (HP:0010566)1.71769518
128Arterial tortuosity (HP:0005116)1.71768706
129Epileptiform EEG discharges (HP:0011182)1.71677157
130Arnold-Chiari malformation (HP:0002308)1.71510992
131Deep venous thrombosis (HP:0002625)1.71303359
132Pili torti (HP:0003777)1.70869595
133Aplasia involving bones of the extremities (HP:0009825)1.70326120
134Aplasia involving bones of the upper limbs (HP:0009823)1.70326120
135Aplasia of the phalanges of the hand (HP:0009802)1.70326120
136Anophthalmia (HP:0000528)1.69835864
137Neurofibrillary tangles (HP:0002185)1.68708856
138Bladder diverticulum (HP:0000015)1.68595999
139Spinal cord compression (HP:0002176)1.68181293
140Elfin facies (HP:0004428)1.68096925
141Anxiety (HP:0000739)1.67433299
142Cerebral inclusion bodies (HP:0100314)1.67135244
143EEG with generalized epileptiform discharges (HP:0011198)1.66818780
144Abnormality of the lacrimal duct (HP:0011481)1.66663804
145Abnormality of the Achilles tendon (HP:0005109)1.66279212
146Postural instability (HP:0002172)1.66230074
147Back pain (HP:0003418)1.65536894
148Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.65402197
149Hemiparesis (HP:0001269)1.65320185
150Male infertility (HP:0003251)1.65041478
151Hypercalcemia (HP:0003072)1.64505272
152Excessive salivation (HP:0003781)1.63190743
153Drooling (HP:0002307)1.63190743
154Absent eyelashes (HP:0000561)1.63121750
155Broad distal phalanx of finger (HP:0009836)1.63089489
156Midline defect of the nose (HP:0004122)1.63071050
157Bowing of the arm (HP:0006488)1.62133733
158Bowed forearm bones (HP:0003956)1.62133733
159Short 4th metacarpal (HP:0010044)1.61671323
160Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.61671323
161Poor eye contact (HP:0000817)1.61623258
162Abnormal ossification of hand bones (HP:0005921)1.61246194
163Vascular tortuosity (HP:0004948)1.61198442
164Dysmetria (HP:0001310)1.60923199
165Hypsarrhythmia (HP:0002521)1.60864091
166Impaired social interactions (HP:0000735)1.60385307
167Abnormal social behavior (HP:0012433)1.60385307
168Abnormality of the diencephalon (HP:0010662)1.59732702
169Nasolacrimal duct obstruction (HP:0000579)1.59708325
170Decreased lacrimation (HP:0000633)1.59080689
171Abnormality of the astrocytes (HP:0100707)1.58853112
172Astrocytoma (HP:0009592)1.58853112
173Adrenal overactivity (HP:0002717)1.58774351
174Choanal stenosis (HP:0000452)1.57901091
175Impaired vibration sensation in the lower limbs (HP:0002166)1.57281241
176Hypoventilation (HP:0002791)1.57153551
177Long palpebral fissure (HP:0000637)1.57081388
178Failure to thrive in infancy (HP:0001531)1.56423119
179Pancreatic islet-cell hyperplasia (HP:0004510)1.56188454
180Preaxial foot polydactyly (HP:0001841)1.54690498
181Impaired smooth pursuit (HP:0007772)1.54002468
182Volvulus (HP:0002580)1.53867375
183Abnormality of the labia minora (HP:0012880)1.53656176
184Anterior segment dysgenesis (HP:0007700)1.53396603
185Hydroureter (HP:0000072)1.53150667

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.64068650
2DDR23.78185955
3EEF2K3.55212226
4LMTK23.47885689
5SMG13.28713862
6NTRK33.17388531
7CDK193.03187582
8MAP3K92.77885074
9EPHA42.74296542
10MST1R2.56063543
11ICK2.46947853
12SIK12.35950061
13PRKD32.35661649
14CDK122.33579726
15TYRO32.14831758
16TIE12.14566242
17UHMK12.06862922
18DAPK12.02407548
19MAPK151.96288788
20PDGFRA1.93799393
21MAP3K41.92773421
22EPHB21.85274337
23MINK11.84471709
24NTRK21.83856203
25PKN21.83299568
26NTRK11.76284255
27MARK11.75301621
28PAK41.68971178
29FGFR41.67690823
30MET1.66589730
31NME21.66344272
32DAPK21.66040582
33MAP3K61.61498110
34PAK61.60922870
35LATS21.56761592
36MAP3K101.56566540
37TESK11.44817732
38RIPK11.44811585
39FGR1.41282928
40TTN1.40664819
41SIK21.40065329
42KSR11.33673274
43PNCK1.32900494
44MAP2K41.29804890
45PINK11.28701178
46MAP3K31.22223768
47CDC42BPA1.20807590
48STK381.16822358
49NME11.14237064
50PHKG21.14208877
51PHKG11.14208877
52CDK51.13486761
53MTOR1.12290308
54KSR21.11704010
55MAP3K21.10939029
56PRKD21.10013420
57PBK1.07947311
58ARAF1.05801942
59BMX0.98276770
60TTK0.96603246
61MAP2K70.95540339
62WEE10.94529709
63CAMKK10.93363126
64FER0.92706583
65AKT30.90321607
66TRIB30.85807877
67SGK10.85133707
68PTK60.84067275
69PTK20.83703345
70HIPK20.83390446
71DYRK1B0.81277506
72GRK50.80503487
73ALK0.78054049
74CDK70.77325630
75INSRR0.75928441
76PLK20.74796897
77CAMK2A0.74792020
78CSNK1G20.74312522
79CAMK2B0.74134627
80PRKCH0.74002308
81AKT20.72751232
82WNK40.72580090
83IRAK30.70986591
84STK110.70788543
85PAK30.70673365
86MAP3K120.69874228
87PRKCG0.69714663
88PTK2B0.68961955
89CDK11A0.68612943
90CAMK1G0.66644823
91TAOK10.65332085
92CDK150.63577150
93PRPF4B0.62868421
94FGFR20.62852212
95MAPKAPK30.62329738
96CDK180.61905212
97MATK0.61318741
98KIT0.59425267
99CDK140.59040286
100BRAF0.58575895
101RET0.58228398
102ERBB30.57448821
103LRRK20.55731278
104RPS6KB20.55486376
105EPHB10.54658980
106MAP3K110.54277583
107MAPK130.53817633
108MAPK100.53523307
109ERN10.52646884
110LATS10.52060617
111WNK30.51742465
112ILK0.51495109
113DMPK0.51458035
114RIPK40.50968592
115MARK20.50912427
116LIMK10.49648206
117PDPK10.49387551
118RPS6KA30.48632932
119SCYL20.47576887
120FGFR10.47568273
121CSNK1G10.47498277
122CSNK1G30.46803762
123YES10.46303190
124PRKCZ0.45675653
125STK38L0.45633498
126AURKA0.44810503
127RPS6KL10.44782138
128RPS6KC10.44782138
129ROCK20.44490671
130GSK3A0.44055067
131CDK60.43676731
132MAP2K20.42906264
133MUSK0.42277695
134KDR0.40811035
135TESK20.40534040
136ERBB20.40082327
137MAP3K80.39508074
138PDGFRB0.39440959
139CAMK2D0.39365824
140CSNK1E0.38750083
141DYRK1A0.37538756
142RPS6KA20.37316827
143CAMK2G0.35589454
144TAOK20.31900929
145RPS6KA10.30660707
146PRKCI0.30445710
147BRSK10.29777563
148MAP3K70.29532209
149CHEK20.28941881
150NEK60.28516164
151ABL20.26147716
152DAPK30.26116021
153SRC0.25807668
154SGK30.25681512
155RPS6KA60.25484071
156NEK20.25003014
157PAK20.23559485

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.82005598
2Synaptic vesicle cycle_Homo sapiens_hsa047212.65496356
3Amphetamine addiction_Homo sapiens_hsa050312.43293101
4Long-term potentiation_Homo sapiens_hsa047202.32222782
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23409164
6Circadian entrainment_Homo sapiens_hsa047132.22039891
7ECM-receptor interaction_Homo sapiens_hsa045122.14076980
8GABAergic synapse_Homo sapiens_hsa047272.13195172
9Insulin secretion_Homo sapiens_hsa049112.10148747
10Glutamatergic synapse_Homo sapiens_hsa047242.04869957
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.01942571
12Dopaminergic synapse_Homo sapiens_hsa047281.96402639
13Biosynthesis of amino acids_Homo sapiens_hsa012301.89818719
14Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84099617
15Olfactory transduction_Homo sapiens_hsa047401.82117474
16Cocaine addiction_Homo sapiens_hsa050301.76515489
17Phenylalanine metabolism_Homo sapiens_hsa003601.76028785
18Salivary secretion_Homo sapiens_hsa049701.75828828
19Morphine addiction_Homo sapiens_hsa050321.74840608
20Gastric acid secretion_Homo sapiens_hsa049711.71409280
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.71108465
22Long-term depression_Homo sapiens_hsa047301.63825640
23Taste transduction_Homo sapiens_hsa047421.58460902
24Cholinergic synapse_Homo sapiens_hsa047251.56335614
25Gap junction_Homo sapiens_hsa045401.54335325
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53820355
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.53368397
28Dorso-ventral axis formation_Homo sapiens_hsa043201.49066643
29Renin secretion_Homo sapiens_hsa049241.48723786
30Hedgehog signaling pathway_Homo sapiens_hsa043401.48049825
31Melanogenesis_Homo sapiens_hsa049161.46419840
32Small cell lung cancer_Homo sapiens_hsa052221.45375956
33Fructose and mannose metabolism_Homo sapiens_hsa000511.44673185
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43374436
35Pentose phosphate pathway_Homo sapiens_hsa000301.43052430
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42897377
37Galactose metabolism_Homo sapiens_hsa000521.41035462
38GnRH signaling pathway_Homo sapiens_hsa049121.40897084
39Estrogen signaling pathway_Homo sapiens_hsa049151.37791941
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37761326
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37486712
42Folate biosynthesis_Homo sapiens_hsa007901.36826208
43Thyroid cancer_Homo sapiens_hsa052161.35593630
44Type II diabetes mellitus_Homo sapiens_hsa049301.34185593
45Basal cell carcinoma_Homo sapiens_hsa052171.33318498
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33147867
47Oxytocin signaling pathway_Homo sapiens_hsa049211.33029158
48Axon guidance_Homo sapiens_hsa043601.32643076
49Tyrosine metabolism_Homo sapiens_hsa003501.30519708
50Serotonergic synapse_Homo sapiens_hsa047261.27912309
51Hippo signaling pathway_Homo sapiens_hsa043901.25823660
52Calcium signaling pathway_Homo sapiens_hsa040201.25461294
53Wnt signaling pathway_Homo sapiens_hsa043101.23246594
54Vitamin B6 metabolism_Homo sapiens_hsa007501.22666918
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.19561599
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17571161
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17532177
58Glioma_Homo sapiens_hsa052141.15320946
59Collecting duct acid secretion_Homo sapiens_hsa049661.12518862
60Fatty acid biosynthesis_Homo sapiens_hsa000611.11673430
61Carbon metabolism_Homo sapiens_hsa012001.09462992
62mTOR signaling pathway_Homo sapiens_hsa041501.09129909
63cAMP signaling pathway_Homo sapiens_hsa040241.08913971
64ErbB signaling pathway_Homo sapiens_hsa040121.08810212
65Protein digestion and absorption_Homo sapiens_hsa049741.08311928
66Circadian rhythm_Homo sapiens_hsa047101.07376955
67Vibrio cholerae infection_Homo sapiens_hsa051101.04475076
68Chronic myeloid leukemia_Homo sapiens_hsa052201.02606299
69Arginine biosynthesis_Homo sapiens_hsa002201.02136781
70Oocyte meiosis_Homo sapiens_hsa041141.01749008
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01626248
72Thyroid hormone synthesis_Homo sapiens_hsa049181.01142694
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01134537
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00554062
75Arginine and proline metabolism_Homo sapiens_hsa003301.00136564
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99647027
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99493938
78Notch signaling pathway_Homo sapiens_hsa043300.97830951
79Histidine metabolism_Homo sapiens_hsa003400.97602293
80VEGF signaling pathway_Homo sapiens_hsa043700.97427116
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95283761
82AMPK signaling pathway_Homo sapiens_hsa041520.95171727
83Lysine degradation_Homo sapiens_hsa003100.94615367
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94269036
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.92698176
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92239656
87Sulfur relay system_Homo sapiens_hsa041220.91604900
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88923356
89MicroRNAs in cancer_Homo sapiens_hsa052060.88503332
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87081845
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.86597971
92Other glycan degradation_Homo sapiens_hsa005110.85476470
93Inositol phosphate metabolism_Homo sapiens_hsa005620.84537895
94Glucagon signaling pathway_Homo sapiens_hsa049220.83872432
95Adherens junction_Homo sapiens_hsa045200.83670723
96N-Glycan biosynthesis_Homo sapiens_hsa005100.83446445
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83149722
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.82853251
99Bile secretion_Homo sapiens_hsa049760.82644575
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81989610
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81516357
102MAPK signaling pathway_Homo sapiens_hsa040100.79471068
103Choline metabolism in cancer_Homo sapiens_hsa052310.78566076
104Pancreatic secretion_Homo sapiens_hsa049720.78550425
105Tight junction_Homo sapiens_hsa045300.78278263
106Amoebiasis_Homo sapiens_hsa051460.78026531
107Rap1 signaling pathway_Homo sapiens_hsa040150.76784514
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76564152
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76304918
110Prostate cancer_Homo sapiens_hsa052150.76015586
111Pathways in cancer_Homo sapiens_hsa052000.74617549
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74431426
113Sphingolipid metabolism_Homo sapiens_hsa006000.73312473
114Acute myeloid leukemia_Homo sapiens_hsa052210.71362262
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71210712
116Melanoma_Homo sapiens_hsa052180.71009260
117Dilated cardiomyopathy_Homo sapiens_hsa054140.70864072
118Alcoholism_Homo sapiens_hsa050340.70598232
119Bladder cancer_Homo sapiens_hsa052190.70448660
120Endometrial cancer_Homo sapiens_hsa052130.68927095
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.68362741
122Insulin resistance_Homo sapiens_hsa049310.67100763
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66262892
124Colorectal cancer_Homo sapiens_hsa052100.65669087
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64446982
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64397708
127Proteoglycans in cancer_Homo sapiens_hsa052050.64102453
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63943693
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62976075
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62548201
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61465047
132Insulin signaling pathway_Homo sapiens_hsa049100.60661761
133Renal cell carcinoma_Homo sapiens_hsa052110.59466961
134Focal adhesion_Homo sapiens_hsa045100.58258952
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.57993012
136mRNA surveillance pathway_Homo sapiens_hsa030150.57476687
137TGF-beta signaling pathway_Homo sapiens_hsa043500.57470210
138Ras signaling pathway_Homo sapiens_hsa040140.57263957
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56507439
140Cardiac muscle contraction_Homo sapiens_hsa042600.56142757
141Phototransduction_Homo sapiens_hsa047440.53782306
142Glutathione metabolism_Homo sapiens_hsa004800.53719977
143Endocytosis_Homo sapiens_hsa041440.53563313
144p53 signaling pathway_Homo sapiens_hsa041150.53030258
145Prion diseases_Homo sapiens_hsa050200.50365220
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50055059
147Starch and sucrose metabolism_Homo sapiens_hsa005000.49378761
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49365130
149Pyruvate metabolism_Homo sapiens_hsa006200.48948930
150Central carbon metabolism in cancer_Homo sapiens_hsa052300.47143851
151Non-small cell lung cancer_Homo sapiens_hsa052230.42578640
152Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42037959
153Mineral absorption_Homo sapiens_hsa049780.39987010

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