PTPRR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1short-term memory (GO:0007614)7.81859089
2C4-dicarboxylate transport (GO:0015740)5.05692726
3cerebellar Purkinje cell layer development (GO:0021680)5.05310040
4neurofilament cytoskeleton organization (GO:0060052)4.94898702
5response to histamine (GO:0034776)4.91457951
6neuronal action potential propagation (GO:0019227)4.82479780
7sodium ion export (GO:0071436)4.81116925
8positive regulation of dendritic spine morphogenesis (GO:0061003)4.72095802
9neuron cell-cell adhesion (GO:0007158)4.69768947
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.64325274
11cellular sodium ion homeostasis (GO:0006883)4.61999339
12fructose metabolic process (GO:0006000)4.56534510
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.36400899
14behavioral response to nicotine (GO:0035095)4.32597658
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.30354881
16positive regulation of synaptic transmission, GABAergic (GO:0032230)4.29430974
17vocalization behavior (GO:0071625)4.28252030
18glutamate receptor signaling pathway (GO:0007215)4.26645902
19synaptic vesicle exocytosis (GO:0016079)4.25648661
20synaptic transmission, glutamatergic (GO:0035249)4.18107567
21G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.13313149
22regulation of synaptic vesicle exocytosis (GO:2000300)4.13225816
23layer formation in cerebral cortex (GO:0021819)4.11941539
24cerebellar Purkinje cell differentiation (GO:0021702)4.11575919
25retinal cone cell development (GO:0046549)4.10019613
26prepulse inhibition (GO:0060134)4.07699950
27protein heterotetramerization (GO:0051290)4.05978686
28regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.02582342
29presynaptic membrane assembly (GO:0097105)3.99500421
30positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.99168406
31locomotory exploration behavior (GO:0035641)3.94142740
32gamma-aminobutyric acid signaling pathway (GO:0007214)3.91956464
33neuron-neuron synaptic transmission (GO:0007270)3.87591504
34glutamate secretion (GO:0014047)3.85139153
35positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.84968889
36metanephric nephron tubule development (GO:0072234)3.82347752
37metanephric tubule development (GO:0072170)3.82347752
38cerebellar granule cell differentiation (GO:0021707)3.80580543
39presynaptic membrane organization (GO:0097090)3.78116319
40regulation of synaptic vesicle transport (GO:1902803)3.74469308
41detection of calcium ion (GO:0005513)3.70462184
42protein localization to synapse (GO:0035418)3.68710811
43inositol phosphate-mediated signaling (GO:0048016)3.68561312
44negative regulation of synaptic transmission, GABAergic (GO:0032229)3.62649892
45serotonin metabolic process (GO:0042428)3.59329406
46positive regulation of muscle hypertrophy (GO:0014742)3.58093506
47positive regulation of cardiac muscle hypertrophy (GO:0010613)3.58093506
48musculoskeletal movement (GO:0050881)3.53096100
49multicellular organismal movement (GO:0050879)3.53096100
50response to pheromone (GO:0019236)3.52121943
51postsynaptic membrane organization (GO:0001941)3.50351507
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.48375699
53gamma-aminobutyric acid transport (GO:0015812)3.46123151
54metanephric nephron epithelium development (GO:0072243)3.42667489
55neurotransmitter secretion (GO:0007269)3.41652904
56potassium ion homeostasis (GO:0055075)3.41547846
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.41341272
58regulation of dendritic spine morphogenesis (GO:0061001)3.41051507
59regulation of potassium ion transmembrane transporter activity (GO:1901016)3.38760088
60relaxation of smooth muscle (GO:0044557)3.38645495
61regulation of glutamate receptor signaling pathway (GO:1900449)3.37624124
62collecting duct development (GO:0072044)3.36434538
63transmission of nerve impulse (GO:0019226)3.35793380
64regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.32826639
65cell differentiation in hindbrain (GO:0021533)3.32205951
66regulation of potassium ion transmembrane transport (GO:1901379)3.31738723
67synaptic vesicle maturation (GO:0016188)3.30564256
68primary amino compound metabolic process (GO:1901160)3.27206369
69membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.26374166
70acidic amino acid transport (GO:0015800)3.23493354
71regulation of vesicle fusion (GO:0031338)3.23275695
72regulation of neurotransmitter secretion (GO:0046928)3.21353342
73retina layer formation (GO:0010842)3.20696349
74metanephric epithelium development (GO:0072207)3.15250734
75regulation of excitatory postsynaptic membrane potential (GO:0060079)3.13047806
76synaptic vesicle endocytosis (GO:0048488)3.12337863
77behavioral response to ethanol (GO:0048149)3.11743292
78regulation of synapse structural plasticity (GO:0051823)3.10453634
79membrane depolarization during action potential (GO:0086010)3.09314524
80neuronal action potential (GO:0019228)3.06965900
81cellular potassium ion homeostasis (GO:0030007)3.06500033
82regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05951917
83innervation (GO:0060384)3.05596863
84synaptic vesicle docking involved in exocytosis (GO:0016081)3.05562771
85synapse assembly (GO:0007416)3.04850130
86regulation of postsynaptic membrane potential (GO:0060078)3.04642048
87regulation of synaptic transmission, glutamatergic (GO:0051966)3.04230710
88long-term memory (GO:0007616)3.03557993
89positive regulation of dendritic spine development (GO:0060999)3.03438764
90chemosensory behavior (GO:0007635)3.03027303
91neurotransmitter-gated ion channel clustering (GO:0072578)3.02792069
92neurotransmitter transport (GO:0006836)3.02583932
93negative regulation of heart rate (GO:0010459)3.01354371
94exploration behavior (GO:0035640)3.00633692
95righting reflex (GO:0060013)2.99227810
96positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.96171287
97relaxation of cardiac muscle (GO:0055119)2.95530256
98cGMP metabolic process (GO:0046068)2.94775223
99regulation of synapse maturation (GO:0090128)2.94050199
100regulation of neurotransmitter transport (GO:0051588)2.93008921
101regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.92856591
102sodium ion homeostasis (GO:0055078)2.92829459
103positive regulation of potassium ion transport (GO:0043268)2.91471386
104startle response (GO:0001964)2.90222687
105positive regulation of membrane potential (GO:0045838)2.89684063
106membrane depolarization (GO:0051899)2.87954000
107neuron recognition (GO:0008038)2.86183650
108L-glutamate transport (GO:0015813)2.86183345
109synapse organization (GO:0050808)2.86106044
110regulation of respiratory system process (GO:0044065)2.85874597
111positive regulation of synapse assembly (GO:0051965)2.82358035
112regulation of long-term neuronal synaptic plasticity (GO:0048169)2.82080979
113membrane hyperpolarization (GO:0060081)2.82014040
114negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80634979
115long-term synaptic potentiation (GO:0060291)2.80314973
116synaptic transmission (GO:0007268)2.75791590
117adult walking behavior (GO:0007628)2.73911173
118calcium ion-dependent exocytosis (GO:0017156)2.73894660
119proline transport (GO:0015824)2.73041144
120regulation of neuronal synaptic plasticity (GO:0048168)2.71845678
121positive regulation of synapse maturation (GO:0090129)2.67968293
122regulation of calcium ion-dependent exocytosis (GO:0017158)2.66733180
123neuromuscular synaptic transmission (GO:0007274)2.65309200
124positive regulation of exocytosis (GO:0045921)2.65009965
125positive regulation of potassium ion transmembrane transport (GO:1901381)2.64464346
126regulation of neurotransmitter levels (GO:0001505)2.63627368
127urinary tract smooth muscle contraction (GO:0014848)2.61512495
128potassium ion transmembrane transport (GO:0071805)2.61485592
129cellular potassium ion transport (GO:0071804)2.61485592
130regulation of respiratory gaseous exchange (GO:0043576)2.60022558
131establishment of synaptic vesicle localization (GO:0097480)2.59376785
132synaptic vesicle transport (GO:0048489)2.59376785
133axonal fasciculation (GO:0007413)2.58019598
134regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.57830849
135cochlea development (GO:0090102)2.56854278
136adult behavior (GO:0030534)2.55945243
137neuromuscular process controlling posture (GO:0050884)2.54925026
138response to auditory stimulus (GO:0010996)2.53368017
139fear response (GO:0042596)2.53169905
140negative regulation of dendrite morphogenesis (GO:0050774)2.53158718
141regulation of exocytosis (GO:0017157)2.51951216
142mechanosensory behavior (GO:0007638)2.51798247
143cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.51219954
144regulation of synaptic transmission, GABAergic (GO:0032228)2.50882243
145learning (GO:0007612)2.50854648
146regulation of synaptic plasticity (GO:0048167)2.50719441

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.95624156
2* GBX2_23144817_ChIP-Seq_PC3_Human4.06635433
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66302379
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.57991269
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54676595
6CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.44188536
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.30585184
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30170073
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23865551
10REST_21632747_ChIP-Seq_MESCs_Mouse2.23487526
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20297842
12TAF15_26573619_Chip-Seq_HEK293_Human2.19291039
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16529422
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16529422
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16226789
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.13905632
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.12850319
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12751412
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.11076419
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.07778144
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.03636958
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02387611
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.01097805
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00422457
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98937646
26* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96094833
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.94903365
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.92422735
29IGF1R_20145208_ChIP-Seq_DFB_Human1.89439959
30SMAD4_21799915_ChIP-Seq_A2780_Human1.88757377
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.82162876
32* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82084966
33P300_19829295_ChIP-Seq_ESCs_Human1.80794757
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73862399
35DROSHA_22980978_ChIP-Seq_HELA_Human1.73200306
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72752621
37VDR_22108803_ChIP-Seq_LS180_Human1.67237243
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.67006228
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.63724456
40* REST_18959480_ChIP-ChIP_MESCs_Mouse1.59547622
41AR_21572438_ChIP-Seq_LNCaP_Human1.55307704
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54706007
43RNF2_27304074_Chip-Seq_NSC_Mouse1.52333397
44* STAT3_23295773_ChIP-Seq_U87_Human1.51408168
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50077758
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49380981
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49274344
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48995380
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.48807384
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.48491581
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45996959
52AR_25329375_ChIP-Seq_VCAP_Human1.41631905
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40847780
54* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40842419
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40441696
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39865790
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39324321
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38252347
59FUS_26573619_Chip-Seq_HEK293_Human1.37110174
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35865467
61ZNF274_21170338_ChIP-Seq_K562_Hela1.35690706
62FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.35293987
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.35009251
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34645711
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34639034
66E2F1_18555785_Chip-Seq_ESCs_Mouse1.30262955
67RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30247153
68* TCF4_23295773_ChIP-Seq_U87_Human1.29830121
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28508608
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27892632
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27465301
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27399075
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27300618
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27300618
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27209739
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26021837
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25975337
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25488070
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24935733
80P53_22387025_ChIP-Seq_ESCs_Mouse1.24435753
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22984910
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.22718556
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22567942
84RUNX2_22187159_ChIP-Seq_PCA_Human1.22006557
85JUN_21703547_ChIP-Seq_K562_Human1.21821186
86SOX2_21211035_ChIP-Seq_LN229_Gbm1.21112503
87SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18655509
88RARB_27405468_Chip-Seq_BRAIN_Mouse1.18526055
89STAT3_18555785_Chip-Seq_ESCs_Mouse1.18201860
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16978568
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16469048
92ER_23166858_ChIP-Seq_MCF-7_Human1.15680429
93NMYC_18555785_Chip-Seq_ESCs_Mouse1.14365456
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13754888
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12490049
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11463489
97SOX2_18555785_Chip-Seq_ESCs_Mouse1.10760777
98KDM2B_26808549_Chip-Seq_REH_Human1.09665063
99BCAT_22108803_ChIP-Seq_LS180_Human1.09369377
100P300_18555785_Chip-Seq_ESCs_Mouse1.09180299
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.09033920
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07463758
103TP53_18474530_ChIP-ChIP_U2OS_Human1.07342178
104* TAL1_26923725_Chip-Seq_HPCs_Mouse1.07148521
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.06982477
106P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06437199
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.05429647
108ARNT_22903824_ChIP-Seq_MCF-7_Human1.04820346
109MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04626695
110YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02747466
111* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02534418
112* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02220159
113* AR_19668381_ChIP-Seq_PC3_Human1.02219640
114RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01932910
115CBP_20019798_ChIP-Seq_JUKART_Human0.97679787
116IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97679787
117MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97112983
118PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95009108
119FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94422787
120GATA1_26923725_Chip-Seq_HPCs_Mouse0.94004183
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93398241
122NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.91880967
123EWS_26573619_Chip-Seq_HEK293_Human0.91758865
124* FLI1_21867929_ChIP-Seq_TH2_Mouse0.89602752
125SMAD4_21741376_ChIP-Seq_HESCs_Human0.89540527
126TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89178760
127TCF4_22108803_ChIP-Seq_LS180_Human0.86421647

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.08573335
2MP0003880_abnormal_central_pattern3.57704008
3MP0004270_analgesia3.35784460
4MP0003635_abnormal_synaptic_transmissio3.24140477
5MP0001968_abnormal_touch/_nociception3.07071443
6MP0009046_muscle_twitch3.05217400
7MP0002734_abnormal_mechanical_nocicepti2.86442675
8MP0001188_hyperpigmentation2.83694628
9MP0009745_abnormal_behavioral_response2.81635547
10MP0002736_abnormal_nociception_after2.77013073
11MP0002735_abnormal_chemical_nociception2.73071730
12MP0002272_abnormal_nervous_system2.59755171
13MP0002064_seizures2.52731148
14MP0002572_abnormal_emotion/affect_behav2.51849841
15MP0002063_abnormal_learning/memory/cond2.51447040
16MP0010386_abnormal_urinary_bladder2.44477051
17MP0001984_abnormal_olfaction2.38952300
18MP0001486_abnormal_startle_reflex2.24338650
19MP0002067_abnormal_sensory_capabilities2.23666217
20MP0006276_abnormal_autonomic_nervous2.21326508
21MP0006035_abnormal_mitochondrial_morpho2.20795757
22MP0001440_abnormal_grooming_behavior2.20581597
23MP0005423_abnormal_somatic_nervous2.16527317
24MP0005646_abnormal_pituitary_gland2.13108993
25MP0001501_abnormal_sleep_pattern2.12871890
26MP0002733_abnormal_thermal_nociception2.10564740
27MP0001970_abnormal_pain_threshold2.01633438
28MP0002184_abnormal_innervation2.00226857
29MP0002822_catalepsy1.96901161
30MP0001986_abnormal_taste_sensitivity1.96335830
31MP0008569_lethality_at_weaning1.90681692
32MP0002557_abnormal_social/conspecific_i1.81311671
33MP0005645_abnormal_hypothalamus_physiol1.80697026
34MP0003787_abnormal_imprinting1.75228808
35MP0006292_abnormal_olfactory_placode1.71139950
36MP0000778_abnormal_nervous_system1.64862974
37MP0002638_abnormal_pupillary_reflex1.63285938
38MP0005386_behavior/neurological_phenoty1.59054521
39MP0004924_abnormal_behavior1.59054521
40MP0001502_abnormal_circadian_rhythm1.57779392
41MP0004742_abnormal_vestibular_system1.56003313
42MP0008875_abnormal_xenobiotic_pharmacok1.49619832
43MP0005171_absent_coat_pigmentation1.49560776
44MP0001905_abnormal_dopamine_level1.43544989
45MP0009780_abnormal_chondrocyte_physiolo1.43128850
46MP0003879_abnormal_hair_cell1.42974093
47MP0008874_decreased_physiological_sensi1.40129069
48MP0004145_abnormal_muscle_electrophysio1.37009869
49MP0004142_abnormal_muscle_tone1.35166234
50MP0001529_abnormal_vocalization1.34571850
51MP0000955_abnormal_spinal_cord1.34275414
52MP0002102_abnormal_ear_morphology1.33164372
53MP0005551_abnormal_eye_electrophysiolog1.32487508
54MP0006072_abnormal_retinal_apoptosis1.32286005
55MP0002882_abnormal_neuron_morphology1.28610073
56MP0002876_abnormal_thyroid_physiology1.25774188
57MP0003137_abnormal_impulse_conducting1.22853477
58* MP0002066_abnormal_motor_capabilities/c1.19381500
59MP0004858_abnormal_nervous_system1.16913091
60MP0004043_abnormal_pH_regulation1.15950976
61MP0005394_taste/olfaction_phenotype1.15761442
62MP0005499_abnormal_olfactory_system1.15761442
63MP0005379_endocrine/exocrine_gland_phen1.14149986
64MP0004811_abnormal_neuron_physiology1.11475948
65MP0000631_abnormal_neuroendocrine_gland1.11350893
66MP0003121_genomic_imprinting1.10951812
67MP0001963_abnormal_hearing_physiology1.09572066
68MP0002909_abnormal_adrenal_gland1.07057197
69MP0003633_abnormal_nervous_system1.03018239
70MP0002837_dystrophic_cardiac_calcinosis1.02114398
71MP0003183_abnormal_peptide_metabolism1.01613455
72MP0004147_increased_porphyrin_level0.99745459
73MP0002229_neurodegeneration0.98984249
74MP0002752_abnormal_somatic_nervous0.95494873
75MP0003631_nervous_system_phenotype0.93127522
76MP0000013_abnormal_adipose_tissue0.92778519
77MP0001485_abnormal_pinna_reflex0.92640238
78MP0000015_abnormal_ear_pigmentation0.90992041
79MP0008877_abnormal_DNA_methylation0.89747390
80MP0002152_abnormal_brain_morphology0.88308035
81MP0003283_abnormal_digestive_organ0.87289586
82MP0000026_abnormal_inner_ear0.85080535
83MP0003329_amyloid_beta_deposits0.84778694
84MP0001664_abnormal_digestion0.84506474
85MP0002693_abnormal_pancreas_physiology0.83940403
86MP0002163_abnormal_gland_morphology0.83402086
87MP0005253_abnormal_eye_physiology0.82673258
88MP0008872_abnormal_physiological_respon0.82509432
89MP0008789_abnormal_olfactory_epithelium0.81104607
90MP0004885_abnormal_endolymph0.80841464
91MP0002751_abnormal_autonomic_nervous0.77996154
92MP0005409_darkened_coat_color0.77529297
93MP0002069_abnormal_eating/drinking_beha0.77428141
94MP0000538_abnormal_urinary_bladder0.77421769
95MP0001299_abnormal_eye_distance/0.77165840
96MP0003123_paternal_imprinting0.75440622
97MP0003632_abnormal_nervous_system0.71791706
98MP0000678_abnormal_parathyroid_gland0.71488334
99MP0005535_abnormal_body_temperature0.70843851
100MP0005410_abnormal_fertilization0.70493159
101MP0000462_abnormal_digestive_system0.70370800
102MP0004085_abnormal_heartbeat0.70365846
103MP0000920_abnormal_myelination0.69887222
104MP0005620_abnormal_muscle_contractility0.69656438
105MP0004215_abnormal_myocardial_fiber0.68987464
106MP0003122_maternal_imprinting0.68515586
107MP0000569_abnormal_digit_pigmentation0.68375940
108MP0009697_abnormal_copulation0.68170944
109MP0000534_abnormal_ureter_morphology0.66345716
110MP0004484_altered_response_of0.61908365
111MP0000566_synostosis0.61369108
112MP0003868_abnormal_feces_composition0.61357481
113MP0008775_abnormal_heart_ventricle0.61226238
114MP0000749_muscle_degeneration0.60828489
115MP0000372_irregular_coat_pigmentation0.60239490
116MP0000358_abnormal_cell_content/0.59277687
117MP0004036_abnormal_muscle_relaxation0.53972576
118MP0001177_atelectasis0.53326283
119MP0003956_abnormal_body_size0.52140786
120MP0005085_abnormal_gallbladder_physiolo0.51874342
121MP0000751_myopathy0.49526780
122MP0002160_abnormal_reproductive_system0.48622212
123MP0010770_preweaning_lethality0.47869218

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.61068757
2Febrile seizures (HP:0002373)5.92293078
3Dysmetric saccades (HP:0000641)5.68035662
4Atonic seizures (HP:0010819)5.47579165
5Progressive cerebellar ataxia (HP:0002073)4.81824228
6Horizontal nystagmus (HP:0000666)4.63098594
7Epileptic encephalopathy (HP:0200134)4.63019149
8Focal seizures (HP:0007359)4.30288849
9Impaired vibration sensation in the lower limbs (HP:0002166)4.22788661
10Myokymia (HP:0002411)4.17219842
11Postural tremor (HP:0002174)4.05470080
12Intention tremor (HP:0002080)3.89867351
13Absence seizures (HP:0002121)3.69575735
14Gaze-evoked nystagmus (HP:0000640)3.56979298
15Action tremor (HP:0002345)3.49692306
16Degeneration of the lateral corticospinal tracts (HP:0002314)3.49150398
17Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.49150398
18Hypothermia (HP:0002045)3.47626763
19Abnormality of the corticospinal tract (HP:0002492)3.41826269
20Visual hallucinations (HP:0002367)3.33964589
21Dialeptic seizures (HP:0011146)3.27802039
22Generalized tonic-clonic seizures (HP:0002069)3.13177842
23Broad-based gait (HP:0002136)3.11892724
24Status epilepticus (HP:0002133)2.93644601
25Gait imbalance (HP:0002141)2.76499619
26Fetal akinesia sequence (HP:0001989)2.75051769
27Acute necrotizing encephalopathy (HP:0006965)2.69726513
28Urinary urgency (HP:0000012)2.66622897
29Medial flaring of the eyebrow (HP:0010747)2.65857611
30Hyperventilation (HP:0002883)2.63952136
31Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.63757716
32Abnormality of saccadic eye movements (HP:0000570)2.62861490
33Insidious onset (HP:0003587)2.58912926
34Termporal pattern (HP:0011008)2.58912926
35Limb dystonia (HP:0002451)2.53160448
36Congenital primary aphakia (HP:0007707)2.52108593
37Autoamputation (HP:0001218)2.51153144
38Abnormal mitochondria in muscle tissue (HP:0008316)2.49520612
39Abnormality of calcium-phosphate metabolism (HP:0100530)2.48898714
40Truncal ataxia (HP:0002078)2.47116349
41Dysdiadochokinesis (HP:0002075)2.46971761
42Absent speech (HP:0001344)2.46913376
43Limb ataxia (HP:0002070)2.44983698
44Nephrogenic diabetes insipidus (HP:0009806)2.41801635
45Hemiparesis (HP:0001269)2.40869309
46Retinal dysplasia (HP:0007973)2.39892726
47Ankle clonus (HP:0011448)2.39569986
48Abnormal hair whorl (HP:0010721)2.37326952
49Epileptiform EEG discharges (HP:0011182)2.36752456
50Impaired smooth pursuit (HP:0007772)2.35772145
51Scanning speech (HP:0002168)2.35615973
52Genital tract atresia (HP:0001827)2.33380300
53Split foot (HP:0001839)2.30771987
54Pancreatic fibrosis (HP:0100732)2.29785884
55Progressive macrocephaly (HP:0004481)2.26345146
56Impaired vibratory sensation (HP:0002495)2.26144922
57Dysmetria (HP:0001310)2.26100755
58EEG with generalized epileptiform discharges (HP:0011198)2.23367670
59Spastic gait (HP:0002064)2.21539773
60Aplasia/Hypoplasia of the fovea (HP:0008060)2.20624724
61Hypoplasia of the fovea (HP:0007750)2.20624724
62Amblyopia (HP:0000646)2.20592763
63Esotropia (HP:0000565)2.20440576
64Focal dystonia (HP:0004373)2.18327688
65Vaginal atresia (HP:0000148)2.17688142
66Generalized hypopigmentation of hair (HP:0011358)2.16947018
67Abnormal eating behavior (HP:0100738)2.14865884
68Acute encephalopathy (HP:0006846)2.14822205
69Pheochromocytoma (HP:0002666)2.14249146
70Genetic anticipation (HP:0003743)2.10571401
71Agitation (HP:0000713)2.10326290
72Abnormality of binocular vision (HP:0011514)2.10295212
73Diplopia (HP:0000651)2.10295212
74Poor suck (HP:0002033)2.09022618
75Inability to walk (HP:0002540)2.09010850
76Abnormality of macular pigmentation (HP:0008002)2.06906858
77Anxiety (HP:0000739)2.06120330
78Abnormal ciliary motility (HP:0012262)2.05405597
79Bradycardia (HP:0001662)2.05187810
80Abnormality of the fovea (HP:0000493)2.04456337
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.04452606
82Aplasia/Hypoplasia of the lens (HP:0008063)2.03867964
83Protruding tongue (HP:0010808)2.03076450
84Decreased circulating renin level (HP:0003351)2.00546226
85Mitochondrial inheritance (HP:0001427)2.00436998
86Syncope (HP:0001279)1.98915275
87Excessive salivation (HP:0003781)1.98315124
88Drooling (HP:0002307)1.98315124
89Spastic tetraplegia (HP:0002510)1.96627396
90Absent/shortened dynein arms (HP:0200106)1.96570343
91Dynein arm defect of respiratory motile cilia (HP:0012255)1.96570343
92Supranuclear gaze palsy (HP:0000605)1.96449467
93Morphological abnormality of the pyramidal tract (HP:0002062)1.95864738
94Poor eye contact (HP:0000817)1.95239914
95Hypsarrhythmia (HP:0002521)1.95094285
96Poor coordination (HP:0002370)1.94923613
97Blue irides (HP:0000635)1.94118493
98Abnormality of midbrain morphology (HP:0002418)1.92839842
99Molar tooth sign on MRI (HP:0002419)1.92839842
100Abnormal respiratory motile cilium physiology (HP:0012261)1.92814521
101Neuroendocrine neoplasm (HP:0100634)1.92580290
102Polyphagia (HP:0002591)1.91510309
103Abnormality of ocular smooth pursuit (HP:0000617)1.88928949
104Congenital sensorineural hearing impairment (HP:0008527)1.88855362
105Nonprogressive disorder (HP:0003680)1.85900078
106Progressive inability to walk (HP:0002505)1.85756071
107Urinary bladder sphincter dysfunction (HP:0002839)1.82442802
108Chronic hepatic failure (HP:0100626)1.82226303
109Cerebral edema (HP:0002181)1.78827219
110True hermaphroditism (HP:0010459)1.78411666
111Specific learning disability (HP:0001328)1.78140203
112Absent eyebrow (HP:0002223)1.76994161
113Failure to thrive in infancy (HP:0001531)1.76741542
114Akinesia (HP:0002304)1.76418148
115Cerebellar atrophy (HP:0001272)1.76032180
116Sleep apnea (HP:0010535)1.76006604
117Exotropia (HP:0000577)1.75229020
118Lower limb muscle weakness (HP:0007340)1.75160944
119Incomplete penetrance (HP:0003829)1.74914091
120Athetosis (HP:0002305)1.74120000
121Increased serum pyruvate (HP:0003542)1.73676242
122Epidermoid cyst (HP:0200040)1.73623885
123Ulnar claw (HP:0001178)1.73515771
124Optic nerve hypoplasia (HP:0000609)1.73226959
125Mutism (HP:0002300)1.73133394
126Depression (HP:0000716)1.72930291
127Slow progression (HP:0003677)1.71945961
128Thyroid-stimulating hormone excess (HP:0002925)1.70760936
129Abnormality of glycolysis (HP:0004366)1.69784483
130Cutaneous finger syndactyly (HP:0010554)1.69428171
131Increased hepatocellular lipid droplets (HP:0006565)1.67552393
132Papillary thyroid carcinoma (HP:0002895)1.66516769
133Fair hair (HP:0002286)1.66038035
134Nephronophthisis (HP:0000090)1.65125393
135Decreased central vision (HP:0007663)1.64611021
136Dysarthria (HP:0001260)1.61421772
137Abnormality of salivation (HP:0100755)1.60774302
138Aplasia/Hypoplasia of the brainstem (HP:0007362)1.60769892
139Hypoplasia of the brainstem (HP:0002365)1.60769892
140Type II lissencephaly (HP:0007260)1.60562853
141Insulin-resistant diabetes mellitus (HP:0000831)1.59657580
142Postaxial hand polydactyly (HP:0001162)1.59034074
143Atrophy/Degeneration involving motor neurons (HP:0007373)1.58864682
144Submucous cleft hard palate (HP:0000176)1.58698939
145Increased CSF lactate (HP:0002490)1.58683179
146Spinal canal stenosis (HP:0003416)1.58165515
147Osteomalacia (HP:0002749)1.57938661
148Abnormality of the labia minora (HP:0012880)1.57487261
149Gait ataxia (HP:0002066)1.57201322
150Median cleft lip (HP:0000161)1.57121934
151Amyotrophic lateral sclerosis (HP:0007354)1.55857915
152Neurofibrillary tangles (HP:0002185)1.55671715
153Humeroradial synostosis (HP:0003041)1.51445479
154Synostosis involving the elbow (HP:0003938)1.51445479
155Unsteady gait (HP:0002317)1.50679147
156Postural instability (HP:0002172)1.49553859

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.28322902
2NTRK33.65518151
3MAP2K73.12006253
4INSRR2.95217990
5TNIK2.60514359
6MAP3K122.58536324
7MAP3K42.47037988
8MAPK132.38075775
9AKT32.35799013
10MAP3K92.27653086
11CSNK1A1L2.19204086
12CSNK1G32.14797081
13MARK12.11693669
14BMPR21.88677202
15PRPF4B1.86487825
16EPHA41.85360294
17CAMKK21.84728793
18MINK11.66553774
19CSNK1G11.65275739
20TRIM281.59816333
21RIPK41.56358558
22MAP2K41.55777614
23NTRK21.54428986
24NTRK11.50908045
25SGK21.48684018
26SIK21.45579733
27MUSK1.42175889
28PAK61.37955585
29PLK21.31507221
30TESK11.30947767
31SGK2231.26065509
32SGK4941.26065509
33PRKG21.25852462
34GRK51.25233750
35BRAF1.24482749
36CCNB11.19387371
37LIMK11.19044462
38CDK191.16139168
39DAPK21.15766986
40PRKD31.15306248
41MYLK1.12848547
42CDK31.09317733
43PRKCG1.05979550
44MAPKAPK51.04389782
45PNCK1.02291316
46MAP4K21.01722736
47CAMK2A1.00745381
48PRKCE1.00418717
49FRK0.99970666
50CDK50.99809173
51NEK60.99151607
52ARAF0.97260177
53MAP3K60.93876525
54PINK10.93364778
55KSR20.91590554
56BCR0.91207851
57MAP3K20.89315589
58WNK10.87699468
59CAMKK10.86593439
60STK380.84716799
61CAMK2B0.83542496
62GRK10.81859110
63OXSR10.80211281
64LATS20.80118895
65TTK0.80007187
66DYRK1A0.76835306
67BMPR1B0.76747401
68GRK70.76588452
69KSR10.76555720
70CAMK2D0.72950756
71SGK30.69115435
72SIK30.68889182
73CDC42BPA0.68467544
74DAPK10.68452352
75NEK10.67145483
76SGK10.66576241
77PRKCA0.66551104
78STK38L0.64811803
79STK160.64694727
80YES10.64301067
81CSNK1A10.63102828
82FES0.63039015
83PAK30.62508618
84HIPK20.61740581
85PDK10.61723597
86CDK11A0.61570839
87MAPK150.61322260
88IRAK20.60413005
89FYN0.59818198
90ERBB40.59800757
91MAP3K130.59299264
92WNK30.59124710
93IRAK10.56092972
94UHMK10.55228335
95ADRBK20.55155779
96CAMK2G0.55102770
97RPS6KA30.54644849
98PRKD20.53894056
99CSNK1E0.53833455
100TNK20.52135983
101PRKCH0.51301670
102NME10.51105812
103PRKG10.51043949
104CAMK10.50220905
105PTK60.49842071
106MAP3K10.48505620
107FER0.48110170
108MARK20.47987349
109* PRKACA0.47686497
110ERBB30.46793079
111CDK180.46327472
112CSNK1G20.46088534
113MAP3K50.46005107
114PRKCZ0.45357706
115PTK2B0.45173812
116CSNK1D0.44951702
117PRKACG0.44267045
118DYRK20.44005551
119PHKG10.43072955
120PHKG20.43072955
121STK390.43044709
122MAP3K110.42777703
123ADRBK10.42344578
124RET0.41498565
125PRKCB0.41198051
126CDK140.40766752
127CDK150.40539755
128WNK40.40335826
129STK110.39115819
130CDK80.38377140
131NUAK10.38085235
132LATS10.37382172
133LMTK20.36120955
134SRC0.35459814
135TSSK60.34947064
136DAPK30.34331955
137CAMK40.32942913
138PRKDC0.30389623

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.93519188
2Nitrogen metabolism_Homo sapiens_hsa009103.37035177
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.85670925
4Synaptic vesicle cycle_Homo sapiens_hsa047212.84346170
5Taste transduction_Homo sapiens_hsa047422.76621854
6Glutamatergic synapse_Homo sapiens_hsa047242.73292693
7Circadian entrainment_Homo sapiens_hsa047132.48602844
8Morphine addiction_Homo sapiens_hsa050322.46997813
9GABAergic synapse_Homo sapiens_hsa047272.42346869
10Long-term potentiation_Homo sapiens_hsa047202.37716705
11Insulin secretion_Homo sapiens_hsa049112.36469206
12Olfactory transduction_Homo sapiens_hsa047402.29989945
13Long-term depression_Homo sapiens_hsa047302.23398148
14Serotonergic synapse_Homo sapiens_hsa047262.21671629
15Amphetamine addiction_Homo sapiens_hsa050312.21542727
16Dopaminergic synapse_Homo sapiens_hsa047281.99610016
17Salivary secretion_Homo sapiens_hsa049701.97280092
18Collecting duct acid secretion_Homo sapiens_hsa049661.87809983
19Cholinergic synapse_Homo sapiens_hsa047251.73564728
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60543416
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.58092879
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57663262
23Cocaine addiction_Homo sapiens_hsa050301.52641356
24Renin secretion_Homo sapiens_hsa049241.51042975
25Calcium signaling pathway_Homo sapiens_hsa040201.47826655
26Gastric acid secretion_Homo sapiens_hsa049711.41463336
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.40176173
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.36097763
29Fructose and mannose metabolism_Homo sapiens_hsa000511.35477182
30Vibrio cholerae infection_Homo sapiens_hsa051101.29165130
31Oxytocin signaling pathway_Homo sapiens_hsa049211.29047216
32Type II diabetes mellitus_Homo sapiens_hsa049301.24319900
33Circadian rhythm_Homo sapiens_hsa047101.23576602
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21618262
35GnRH signaling pathway_Homo sapiens_hsa049121.21310138
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18661188
37cAMP signaling pathway_Homo sapiens_hsa040241.15447327
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.14508560
39Pancreatic secretion_Homo sapiens_hsa049721.11637011
40Phototransduction_Homo sapiens_hsa047441.11089708
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07579521
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07146177
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06945887
44Gap junction_Homo sapiens_hsa045401.05525719
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.04177339
46Pentose phosphate pathway_Homo sapiens_hsa000301.01182165
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99260671
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96171699
49Mineral absorption_Homo sapiens_hsa049780.94715296
50Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91931381
51Axon guidance_Homo sapiens_hsa043600.89577492
52Oxidative phosphorylation_Homo sapiens_hsa001900.88961152
53Cardiac muscle contraction_Homo sapiens_hsa042600.88205176
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86658818
55Renin-angiotensin system_Homo sapiens_hsa046140.86217218
56Estrogen signaling pathway_Homo sapiens_hsa049150.85517504
57Thyroid hormone synthesis_Homo sapiens_hsa049180.85052133
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84963477
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83067168
60Alzheimers disease_Homo sapiens_hsa050100.83056034
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79275836
62Ovarian steroidogenesis_Homo sapiens_hsa049130.77808141
63Inositol phosphate metabolism_Homo sapiens_hsa005620.77643058
64Choline metabolism in cancer_Homo sapiens_hsa052310.77280244
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76427034
66Sphingolipid metabolism_Homo sapiens_hsa006000.73610337
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73047759
68Pyruvate metabolism_Homo sapiens_hsa006200.72321242
69Type I diabetes mellitus_Homo sapiens_hsa049400.71405908
70ErbB signaling pathway_Homo sapiens_hsa040120.71054465
71Melanogenesis_Homo sapiens_hsa049160.69233832
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68887811
73Ether lipid metabolism_Homo sapiens_hsa005650.68262811
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66661091
75Rheumatoid arthritis_Homo sapiens_hsa053230.66055417
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63259313
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.61969651
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61553091
79Ras signaling pathway_Homo sapiens_hsa040140.59744956
80Regulation of autophagy_Homo sapiens_hsa041400.59607403
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59514542
82* MAPK signaling pathway_Homo sapiens_hsa040100.56889657
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56639762
84Oocyte meiosis_Homo sapiens_hsa041140.51887170
85African trypanosomiasis_Homo sapiens_hsa051430.51836620
86Biosynthesis of amino acids_Homo sapiens_hsa012300.51398713
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50738150
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50158853
89Dorso-ventral axis formation_Homo sapiens_hsa043200.49368243
90Huntingtons disease_Homo sapiens_hsa050160.49315731
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.48877591
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46886750
93Glycerolipid metabolism_Homo sapiens_hsa005610.45084895
94Glioma_Homo sapiens_hsa052140.44602594
95Protein export_Homo sapiens_hsa030600.43614426
96Parkinsons disease_Homo sapiens_hsa050120.43322432
97Fatty acid elongation_Homo sapiens_hsa000620.41460402
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.41301429
99Dilated cardiomyopathy_Homo sapiens_hsa054140.40803269
100Phenylalanine metabolism_Homo sapiens_hsa003600.39956093
101Butanoate metabolism_Homo sapiens_hsa006500.38607627
102Arginine and proline metabolism_Homo sapiens_hsa003300.37903628
103Alcoholism_Homo sapiens_hsa050340.37222982
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36142428
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33870036
106Carbon metabolism_Homo sapiens_hsa012000.33471291
107Glucagon signaling pathway_Homo sapiens_hsa049220.33032929
108Arginine biosynthesis_Homo sapiens_hsa002200.32891359
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32853275
110Prolactin signaling pathway_Homo sapiens_hsa049170.32474488
111Bile secretion_Homo sapiens_hsa049760.32278581
112Rap1 signaling pathway_Homo sapiens_hsa040150.31663226
113Melanoma_Homo sapiens_hsa052180.30872299
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30862267
115Wnt signaling pathway_Homo sapiens_hsa043100.30823644
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30524200
117Phagosome_Homo sapiens_hsa041450.28809591
118Propanoate metabolism_Homo sapiens_hsa006400.28651803
119Sulfur metabolism_Homo sapiens_hsa009200.28468073
120Chemokine signaling pathway_Homo sapiens_hsa040620.24906458
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24596620
122Retinol metabolism_Homo sapiens_hsa008300.24377126
123Folate biosynthesis_Homo sapiens_hsa007900.22586943
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21546875
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21034356
126Fatty acid biosynthesis_Homo sapiens_hsa000610.20431227

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