PTPRM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)4.43013643
2regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.36916887
3plasma membrane repair (GO:0001778)4.19945388
4positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.15215175
5lymph vessel development (GO:0001945)4.10257306
6sarcomere organization (GO:0045214)4.06989855
7regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.98248409
8regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.89227111
9vascular endothelial growth factor signaling pathway (GO:0038084)3.87137211
10cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.86091528
11negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.84862055
12myofibril assembly (GO:0030239)3.72513602
13negative regulation of potassium ion transmembrane transport (GO:1901380)3.62033002
14glomerular basement membrane development (GO:0032836)3.61060690
15surfactant homeostasis (GO:0043129)3.50807802
16regulation of actin filament-based movement (GO:1903115)3.49827021
17cell communication by electrical coupling (GO:0010644)3.44739642
18heart trabecula formation (GO:0060347)3.43664625
19cardiac muscle contraction (GO:0060048)3.38637135
20regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.24301023
21regulation of membrane repolarization (GO:0060306)3.21729748
22regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.20717756
23cell communication involved in cardiac conduction (GO:0086065)3.19132619
24retina vasculature morphogenesis in camera-type eye (GO:0061299)3.18077721
25relaxation of cardiac muscle (GO:0055119)3.14965621
26regulation of the force of heart contraction (GO:0002026)3.08693533
27regulation of cell communication by electrical coupling (GO:0010649)3.07785946
28regulation of relaxation of muscle (GO:1901077)3.05091837
29regulation of cardiac muscle cell contraction (GO:0086004)3.04145682
30peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.03343251
31regulation of sarcomere organization (GO:0060297)3.03131668
32cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.02704267
33chemical homeostasis within a tissue (GO:0048875)3.02291745
34detection of calcium ion (GO:0005513)2.99273752
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.96805103
36actomyosin structure organization (GO:0031032)2.93287941
37positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.91013391
38cell adhesion mediated by integrin (GO:0033627)2.90811530
39lymphangiogenesis (GO:0001946)2.90660915
40basement membrane organization (GO:0071711)2.87220750
41endothelium development (GO:0003158)2.86868834
42potassium ion import (GO:0010107)2.86253941
43ventricular cardiac muscle cell action potential (GO:0086005)2.84986327
44regulation of striated muscle contraction (GO:0006942)2.80311692
45sarcoplasmic reticulum calcium ion transport (GO:0070296)2.79952095
46collagen fibril organization (GO:0030199)2.79786512
47regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.79037901
48blood vessel maturation (GO:0001955)2.78696031
49vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.78611672
50endodermal cell differentiation (GO:0035987)2.77867542
51muscle filament sliding (GO:0030049)2.76880967
52actin-myosin filament sliding (GO:0033275)2.76880967
53cardiac muscle hypertrophy (GO:0003300)2.74476205
54adult heart development (GO:0007512)2.74107083
55activation of protein kinase A activity (GO:0034199)2.73046244
56regulation of cardiac muscle contraction (GO:0055117)2.72456559
57ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.68687431
58tricarboxylic acid cycle (GO:0006099)2.65342013
59cardiac muscle cell development (GO:0055013)2.65295067
60striated muscle hypertrophy (GO:0014897)2.63738126
61negative regulation of protein localization to cell surface (GO:2000009)2.61733723
62peripheral nervous system axon ensheathment (GO:0032292)2.61258389
63myelination in peripheral nervous system (GO:0022011)2.61258389
64carnitine shuttle (GO:0006853)2.61018186
65cardiac muscle tissue morphogenesis (GO:0055008)2.60518120
66cell migration involved in heart development (GO:0060973)2.60514821
67negative regulation of potassium ion transport (GO:0043267)2.59706082
68negative regulation of Rho protein signal transduction (GO:0035024)2.59525359
69regulation of skeletal muscle contraction (GO:0014819)2.59424007
70regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.58096887
71mesenchymal-epithelial cell signaling (GO:0060638)2.57769964
72positive regulation of vasculogenesis (GO:2001214)2.56092677
73regulation of cardioblast differentiation (GO:0051890)2.55995879
74cardiac conduction (GO:0061337)2.55013129
75regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.54129225
76fatty acid transmembrane transport (GO:1902001)2.54019802
77negative regulation of cytosolic calcium ion concentration (GO:0051481)2.53552843
78cardiac cell development (GO:0055006)2.53165595
79positive regulation of potassium ion transmembrane transport (GO:1901381)2.53084388
80regulation of synapse structural plasticity (GO:0051823)2.52169212
81regulation of vasculogenesis (GO:2001212)2.52145078
82regulation of calcium ion transmembrane transport (GO:1903169)2.51832451
83regulation of calcium ion transmembrane transporter activity (GO:1901019)2.51832451
84cell migration involved in sprouting angiogenesis (GO:0002042)2.51830424
85coronary vasculature morphogenesis (GO:0060977)2.51729410
86protein heterotrimerization (GO:0070208)2.51397313
87cell-substrate junction assembly (GO:0007044)2.50517732
88regulation of p38MAPK cascade (GO:1900744)2.48744359
89positive regulation of cation channel activity (GO:2001259)2.47582810
90peptidyl-tyrosine autophosphorylation (GO:0038083)2.47255195
91cardiac muscle cell action potential (GO:0086001)2.47225704
92striated muscle contraction (GO:0006941)2.46834425
93protein localization to cell surface (GO:0034394)2.46456939
94metanephric nephron epithelium development (GO:0072243)2.46066735
95metanephric tubule development (GO:0072170)2.45857829
96metanephric nephron tubule development (GO:0072234)2.45857829
97regulation of heart rate (GO:0002027)2.45579708
98cardiac muscle cell action potential involved in contraction (GO:0086002)2.44502447
99membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.44117285
100positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.43882359
101glomerular filtration (GO:0003094)2.43221502
102endothelial cell morphogenesis (GO:0001886)2.41847848
103actin-mediated cell contraction (GO:0070252)2.41235617
104regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.41121038
105regulation of heart contraction (GO:0008016)2.39966057
106skin morphogenesis (GO:0043589)2.39834943
107trabecula formation (GO:0060343)2.39562150
108bundle of His cell to Purkinje myocyte communication (GO:0086069)2.39476191
109muscle tissue morphogenesis (GO:0060415)2.37978883
110regulation of heart rate by cardiac conduction (GO:0086091)2.36410106
111axon extension involved in axon guidance (GO:0048846)2.35998219
112neuron projection extension involved in neuron projection guidance (GO:1902284)2.35998219
113establishment of nucleus localization (GO:0040023)2.34800122
114layer formation in cerebral cortex (GO:0021819)2.34425102
115positive regulation of heart rate (GO:0010460)2.34051580
116embryonic heart tube development (GO:0035050)2.33570229
117venous blood vessel morphogenesis (GO:0048845)2.33537796
118renal filtration (GO:0097205)2.33061968
119actin filament-based movement (GO:0030048)2.32856357
120neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.32703677
121positive regulation of heart contraction (GO:0045823)2.32347792
122regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.31974384
123chondrocyte proliferation (GO:0035988)2.31466706
124collagen metabolic process (GO:0032963)2.30574794
125adherens junction assembly (GO:0034333)2.30567905
126succinate metabolic process (GO:0006105)2.30120216
127sodium ion export (GO:0071436)2.29913522
128protein targeting to Golgi (GO:0000042)2.29433760
129vocalization behavior (GO:0071625)2.29352485
130metanephric epithelium development (GO:0072207)2.27099648
131focal adhesion assembly (GO:0048041)2.25930819
132cell-substrate adherens junction assembly (GO:0007045)2.25930819
133substrate-dependent cell migration (GO:0006929)2.25787761
134negative regulation of fatty acid transport (GO:2000192)2.24555616
135response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.24351869
136cellular response to epinephrine stimulus (GO:0071872)2.23217151
137substrate adhesion-dependent cell spreading (GO:0034446)2.23018054
138extracellular matrix assembly (GO:0085029)2.22356035
139response to epinephrine (GO:0071871)2.21490187
140collagen catabolic process (GO:0030574)2.21002477
141endocrine hormone secretion (GO:0060986)2.20746006
142negative regulation of vascular permeability (GO:0043116)2.20738792
143insulin-like growth factor receptor signaling pathway (GO:0048009)2.19457853
144paraxial mesoderm development (GO:0048339)2.19022074
145multicellular organismal macromolecule metabolic process (GO:0044259)2.18703229
146regulation of lipoprotein metabolic process (GO:0050746)2.18523938
147cytoskeletal anchoring at plasma membrane (GO:0007016)2.18139516
148regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.14027173
149multicellular organismal metabolic process (GO:0044236)2.13069766
150regulation of integrin-mediated signaling pathway (GO:2001044)2.12729005
151endocardial cushion development (GO:0003197)2.12432059
152extracellular fibril organization (GO:0043206)2.12356160
153positive regulation of osteoblast proliferation (GO:0033690)2.11824913
154regulation of axon extension involved in axon guidance (GO:0048841)2.11182793
155muscle hypertrophy (GO:0014896)2.10294753
156positive regulation of cardiac muscle hypertrophy (GO:0010613)2.09634897
157positive regulation of muscle hypertrophy (GO:0014742)2.09634897
158apoptotic cell clearance (GO:0043277)2.07423408
159extracellular matrix disassembly (GO:0022617)2.07394894
160sequestering of extracellular ligand from receptor (GO:0035581)2.07043389
161smooth muscle tissue development (GO:0048745)2.05983582
162camera-type eye morphogenesis (GO:0048593)2.05687880
163macroautophagy (GO:0016236)2.04098807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.47283789
2EP300_21415370_ChIP-Seq_HL-1_Mouse2.62910215
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.55048173
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.39747063
5* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22616994
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.19753869
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.17235216
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12895500
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12895500
10GBX2_23144817_ChIP-Seq_PC3_Human2.09582286
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97994335
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.94701841
13* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.92522164
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91481806
15EED_16625203_ChIP-ChIP_MESCs_Mouse1.91260829
16DROSHA_22980978_ChIP-Seq_HELA_Human1.90067777
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87144527
18* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.86728524
19SMAD_19615063_ChIP-ChIP_OVARY_Human1.74847389
20* EZH2_27304074_Chip-Seq_ESCs_Mouse1.74357706
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73317092
22* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72151429
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.66954711
24* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.65925638
25* TBX20_22328084_ChIP-Seq_HEART_Mouse1.65694288
26* TBX20_22080862_ChIP-Seq_HEART_Mouse1.65694288
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.59912187
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.57334639
29GATA2_21666600_ChIP-Seq_HMVEC_Human1.55833019
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.52615164
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52005488
32AR_21572438_ChIP-Seq_LNCaP_Human1.51693833
33CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.47228662
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47108025
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46460016
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.40890501
37AHR_22903824_ChIP-Seq_MCF-7_Human1.40838593
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39858554
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38211991
40CLOCK_20551151_ChIP-Seq_293T_Human1.35419524
41SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34831921
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34428728
43* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30983581
44NFIB_24661679_ChIP-Seq_LUNG_Mouse1.30835211
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.30084444
46* FOXA2_19822575_ChIP-Seq_HepG2_Human1.29885556
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29548084
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29533684
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.29189165
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.28805058
51* SMAD4_21799915_ChIP-Seq_A2780_Human1.27249237
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26940399
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26855013
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.26315392
55BCAT_22108803_ChIP-Seq_LS180_Human1.25139821
56* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25030949
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22728231
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22596988
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22282443
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22265585
61CJUN_26792858_Chip-Seq_BT549_Human1.21693988
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21502315
63BRD4_25478319_ChIP-Seq_HGPS_Human1.21450007
64ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.20938291
65* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19786124
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19346376
67ISL1_27105846_Chip-Seq_CPCs_Mouse1.19325439
68RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17510198
69* SOX2_21211035_ChIP-Seq_LN229_Gbm1.16250562
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.15959005
71LXR_22158963_ChIP-Seq_LIVER_Mouse1.15575107
72* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14493869
73ZNF274_21170338_ChIP-Seq_K562_Hela1.12883654
74CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12468350
75* SMAD4_21741376_ChIP-Seq_HESCs_Human1.11437692
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10158854
77* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10094440
78* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10094440
79* SMAD3_21741376_ChIP-Seq_HESCs_Human1.08946462
80TCF4_18268006_ChIP-ChIP_LS174T_Human1.08640374
81* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08503036
82* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07953919
83* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07732332
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.07206855
85ZNF263_19887448_ChIP-Seq_K562_Human1.07206827
86KDM2B_26808549_Chip-Seq_K562_Human1.06801453
87* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06710290
88* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05143127
89CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04857510
90* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04122458
91RARB_27405468_Chip-Seq_BRAIN_Mouse1.03696566
92FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03223915
93* TP53_16413492_ChIP-PET_HCT116_Human1.03208164
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02957508
95* SMAD3_21741376_ChIP-Seq_EPCs_Human1.00516151
96SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00499981
97* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00241545
98* AR_19668381_ChIP-Seq_PC3_Human0.99355199
99RXR_22108803_ChIP-Seq_LS180_Human0.99169689
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99022307
101* TP53_18474530_ChIP-ChIP_U2OS_Human0.98861704
102MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.98478849
103TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97690103
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97256456
105TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97243216
106* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97115133
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96639672
108KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96619063
109PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95584478
110TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95561912
111* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94599105
112PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94339489
113AR_25329375_ChIP-Seq_VCAP_Human0.94146916
114* STAT3_23295773_ChIP-Seq_U87_Human0.92840535
115SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92736063
116DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92194332
117ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91360598
118* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91270872
119NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90882788
120CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90530499
121GATA1_22025678_ChIP-Seq_K562_Human0.90325988
122* TP53_23651856_ChIP-Seq_MEFs_Mouse0.90217816

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.61640483
2MP0004084_abnormal_cardiac_muscle4.30228868
3MP0004215_abnormal_myocardial_fiber3.67105023
4MP0000751_myopathy3.66999820
5MP0010368_abnormal_lymphatic_system3.28268551
6MP0004036_abnormal_muscle_relaxation3.02172857
7MP0004272_abnormal_basement_membrane2.96041263
8MP0005257_abnormal_intraocular_pressure2.85449199
9MP0003646_muscle_fatigue2.75576140
10MP0001879_abnormal_lymphatic_vessel2.75237103
11MP0005167_abnormal_blood-brain_barrier2.57777600
12MP0006138_congestive_heart_failure2.52007451
13MP0005330_cardiomyopathy2.46003817
14MP0004484_altered_response_of2.43873415
15MP0002972_abnormal_cardiac_muscle2.34102030
16MP0008775_abnormal_heart_ventricle2.17796702
17MP0009780_abnormal_chondrocyte_physiolo2.15529177
18MP0000749_muscle_degeneration2.10874548
19MP0004130_abnormal_muscle_cell2.10092821
20MP0005171_absent_coat_pigmentation2.08448069
21MP0005623_abnormal_meninges_morphology2.08104883
22MP0005620_abnormal_muscle_contractility2.05264670
23MP0000013_abnormal_adipose_tissue2.02184947
24MP0004087_abnormal_muscle_fiber1.99618725
25MP0008438_abnormal_cutaneous_collagen1.98855608
26MP0003828_pulmonary_edema1.94638692
27MP0004085_abnormal_heartbeat1.92130165
28MP0001544_abnormal_cardiovascular_syste1.91997362
29MP0005385_cardiovascular_system_phenoty1.91997362
30MP0003137_abnormal_impulse_conducting1.85301787
31MP0004145_abnormal_muscle_electrophysio1.82905013
32MP0003279_aneurysm1.81303826
33MP0010630_abnormal_cardiac_muscle1.76120272
34MP0001958_emphysema1.70832565
35MP0005670_abnormal_white_adipose1.65547923
36MP0000750_abnormal_muscle_regeneration1.64108731
37MP0005409_darkened_coat_color1.52132390
38MP0003705_abnormal_hypodermis_morpholog1.44810048
39MP0002106_abnormal_muscle_physiology1.44458156
40MP0003045_fibrosis1.35264657
41MP0005369_muscle_phenotype1.34350950
42MP0004859_abnormal_synaptic_plasticity1.29874274
43MP0005666_abnormal_adipose_tissue1.27540099
44MP0002332_abnormal_exercise_endurance1.27506811
45MP0002127_abnormal_cardiovascular_syste1.27340446
46MP0010030_abnormal_orbit_morphology1.26769924
47MP0002909_abnormal_adrenal_gland1.26166371
48MP0002295_abnormal_pulmonary_circulatio1.25371958
49MP0000759_abnormal_skeletal_muscle1.24427899
50MP0002108_abnormal_muscle_morphology1.24230973
51MP0000003_abnormal_adipose_tissue1.20616057
52MP0005165_increased_susceptibility_to1.20583141
53MP0003950_abnormal_plasma_membrane1.20055523
54MP0004233_abnormal_muscle_weight1.19735806
55MP0005375_adipose_tissue_phenotype1.16281387
56MP0000747_muscle_weakness1.13897615
57MP0005023_abnormal_wound_healing1.12826755
58MP0002269_muscular_atrophy1.12460293
59MP0009384_cardiac_valve_regurgitation1.10082232
60MP0005275_abnormal_skin_tensile1.09129895
61MP0009046_muscle_twitch1.09110186
62MP0005508_abnormal_skeleton_morphology1.08746933
63MP0000767_abnormal_smooth_muscle1.08134392
64MP0000534_abnormal_ureter_morphology1.07054027
65MP0003635_abnormal_synaptic_transmissio1.06784992
66MP0003122_maternal_imprinting1.06564162
67MP0001661_extended_life_span1.05233729
68MP0002971_abnormal_brown_adipose1.02594537
69MP0005503_abnormal_tendon_morphology1.00928464
70MP0004185_abnormal_adipocyte_glucose1.00132884
71MP0004510_myositis0.96449714
72MP0003941_abnormal_skin_development0.96328837
73MP0009250_abnormal_appendicular_skeleto0.94905603
74MP0002128_abnormal_blood_circulation0.93919479
75MP0003566_abnormal_cell_adhesion0.93847495
76* MP0005595_abnormal_vascular_smooth0.93064105
77MP0000266_abnormal_heart_morphology0.90543396
78MP0000230_abnormal_systemic_arterial0.88456979
79MP0003879_abnormal_hair_cell0.88000193
80MP0009840_abnormal_foam_cell0.87148264
81MP0001915_intracranial_hemorrhage0.85743073
82MP0002877_abnormal_melanocyte_morpholog0.83473175
83MP0003091_abnormal_cell_migration0.81797839
84MP0000733_abnormal_muscle_development0.80633459
85MP0002133_abnormal_respiratory_system0.80249572
86MP0005388_respiratory_system_phenotype0.80249572
87MP0001542_abnormal_bone_strength0.80238575
88MP0000343_altered_response_to0.79851344
89MP0002925_abnormal_cardiovascular_devel0.79174086
90MP0008961_abnormal_basal_metabolism0.78836070
91MP0004147_increased_porphyrin_level0.78012098
92MP0000762_abnormal_tongue_morphology0.77399302
93MP0001299_abnormal_eye_distance/0.75442211
94MP0005164_abnormal_response_to0.75359902
95MP0002060_abnormal_skin_morphology0.75298185
96MP0005248_abnormal_Harderian_gland0.75245514
97MP0005187_abnormal_penis_morphology0.75150036
98MP0006054_spinal_hemorrhage0.74793830
99MP0000372_irregular_coat_pigmentation0.72960338
100MP0000163_abnormal_cartilage_morphology0.72201313
101MP0002064_seizures0.72151030
102MP0003942_abnormal_urinary_system0.71594249
103MP0002896_abnormal_bone_mineralization0.70989565
104MP0003283_abnormal_digestive_organ0.70555340
105MP0009745_abnormal_behavioral_response0.68504831
106MP0002876_abnormal_thyroid_physiology0.66490209
107MP0002168_other_aberrant_phenotype0.66197092
108MP0008569_lethality_at_weaning0.65956219
109MP0004858_abnormal_nervous_system0.65808583
110MP0004270_analgesia0.65254400
111MP0003329_amyloid_beta_deposits0.64839172
112MP0001486_abnormal_startle_reflex0.64690302
113MP0002115_abnormal_skeleton_extremities0.64148886
114MP0001614_abnormal_blood_vessel0.63561073
115MP0004924_abnormal_behavior0.63540430
116MP0005386_behavior/neurological_phenoty0.63540430
117MP0000462_abnormal_digestive_system0.62911839
118MP0002063_abnormal_learning/memory/cond0.60105361
119MP0003633_abnormal_nervous_system0.58595523
120MP0002272_abnormal_nervous_system0.58264952
121MP0002234_abnormal_pharynx_morphology0.58255402
122MP0000249_abnormal_blood_vessel0.58040966
123MP0001177_atelectasis0.57328494
124MP0004043_abnormal_pH_regulation0.57286129
125MP0003385_abnormal_body_wall0.55323584

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.70175235
2Atrial fibrillation (HP:0005110)4.60298224
3Muscle fiber splitting (HP:0003555)4.58185305
4Ventricular tachycardia (HP:0004756)4.30940700
5Primary atrial arrhythmia (HP:0001692)4.29510886
6Supraventricular arrhythmia (HP:0005115)4.13382193
7Hyporeflexia of lower limbs (HP:0002600)4.04755008
8Supraventricular tachycardia (HP:0004755)4.04515505
9Calf muscle hypertrophy (HP:0008981)4.01841654
10Exercise-induced muscle cramps (HP:0003710)3.84244926
11Exercise-induced myalgia (HP:0003738)3.81613260
12Broad metatarsal (HP:0001783)3.80353565
13Prolonged QT interval (HP:0001657)3.76310896
14Abnormality of the calf musculature (HP:0001430)3.72870671
15Syncope (HP:0001279)3.67049714
16Muscle hypertrophy of the lower extremities (HP:0008968)3.65189457
17Lipoatrophy (HP:0100578)3.53203153
18Bundle branch block (HP:0011710)3.47432737
19Difficulty running (HP:0009046)3.47043094
20Right ventricular cardiomyopathy (HP:0011663)3.39629557
21Increased connective tissue (HP:0009025)3.38114031
22Cerebral aneurysm (HP:0004944)3.22506527
23Asymmetric septal hypertrophy (HP:0001670)3.10823615
24Increased variability in muscle fiber diameter (HP:0003557)3.08196039
25Myotonia (HP:0002486)3.04618758
26Wormian bones (HP:0002645)3.03446567
27Ventricular fibrillation (HP:0001663)2.99487258
28EMG: myopathic abnormalities (HP:0003458)2.96466158
29Abnormality of the left ventricular outflow tract (HP:0011103)2.93974955
30Subaortic stenosis (HP:0001682)2.93974955
31Ventricular arrhythmia (HP:0004308)2.90111561
32Myoglobinuria (HP:0002913)2.85043764
33Dilated cardiomyopathy (HP:0001644)2.79678334
34Soft skin (HP:0000977)2.76046750
35Neonatal short-limb short stature (HP:0008921)2.72651066
36Heart block (HP:0012722)2.71630414
37Abnormal EKG (HP:0003115)2.67101676
38Atrioventricular block (HP:0001678)2.62413895
39Abnormality of skeletal muscle fiber size (HP:0012084)2.61288860
40Abnormal atrioventricular conduction (HP:0005150)2.58699844
41Palpitations (HP:0001962)2.55226625
42Hypoplastic ischia (HP:0003175)2.54470304
43Polycythemia (HP:0001901)2.51875354
44Mitral stenosis (HP:0001718)2.51174637
45Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.50968997
46Muscle fiber inclusion bodies (HP:0100299)2.45912330
47Difficulty climbing stairs (HP:0003551)2.43114075
48Cervical subluxation (HP:0003308)2.43033919
49Nemaline bodies (HP:0003798)2.39349392
50Lymphangioma (HP:0100764)2.35203686
51Abnormality of the ischium (HP:0003174)2.35161668
52Vertebral compression fractures (HP:0002953)2.34335541
53Hypoplasia of the iris (HP:0007676)2.33052067
54Osteolytic defects of the hand bones (HP:0009699)2.30065039
55Osteolytic defects of the phalanges of the hand (HP:0009771)2.30065039
56Protrusio acetabuli (HP:0003179)2.29165200
57Ankle contracture (HP:0006466)2.26433351
58Dysmetric saccades (HP:0000641)2.26187217
59Aneurysm (HP:0002617)2.25242702
60Wide anterior fontanel (HP:0000260)2.21065871
61Shallow orbits (HP:0000586)2.20129694
62Premature rupture of membranes (HP:0001788)2.19914250
63Fragile skin (HP:0001030)2.18644987
64Round ear (HP:0100830)2.16679670
65Abnormality of dentin (HP:0010299)2.13545805
66Mitral valve prolapse (HP:0001634)2.13315286
67Hemiplegia (HP:0002301)2.12542560
68Hematochezia (HP:0002573)2.10210523
69Limited hip movement (HP:0008800)2.07765248
70Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.07705534
71Focal motor seizures (HP:0011153)2.06809677
72Left ventricular hypertrophy (HP:0001712)2.05615177
73Spinal rigidity (HP:0003306)2.04208456
74Hyperinsulinemic hypoglycemia (HP:0000825)2.03676747
75Scapular winging (HP:0003691)2.02495101
76Mildly elevated creatine phosphokinase (HP:0008180)2.01629924
77Hyperextensible skin (HP:0000974)2.00907274
78Type 1 muscle fiber predominance (HP:0003803)1.99326194
79Ketoacidosis (HP:0001993)1.98437802
80Aortic aneurysm (HP:0004942)1.96709990
81Vascular tortuosity (HP:0004948)1.94447393
82Cardiovascular calcification (HP:0011915)1.94215586
83Overgrowth (HP:0001548)1.93899707
84Follicular hyperkeratosis (HP:0007502)1.92749225
85Cerebral hemorrhage (HP:0001342)1.92243457
86Blue sclerae (HP:0000592)1.91086334
87Visceral angiomatosis (HP:0100761)1.90746793
88Neck muscle weakness (HP:0000467)1.89821954
89Dilatation of the ascending aorta (HP:0005111)1.89535825
90Muscle stiffness (HP:0003552)1.88925377
91Hypoglycemic coma (HP:0001325)1.88762235
92Bradycardia (HP:0001662)1.88261478
93Pheochromocytoma (HP:0002666)1.87933837
94Arterial tortuosity (HP:0005116)1.87433860
95Striae distensae (HP:0001065)1.84644527
96Rapidly progressive (HP:0003678)1.84602107
97Spondylolisthesis (HP:0003302)1.84573403
98Vertebral arch anomaly (HP:0008438)1.84403213
99Muscular dystrophy (HP:0003560)1.83707235
100Ulnar bowing (HP:0003031)1.82394666
101Ulnar deviation of the wrist (HP:0003049)1.82169470
102Mitral regurgitation (HP:0001653)1.81394280
103Complement deficiency (HP:0004431)1.81296517
104Distal arthrogryposis (HP:0005684)1.81071312
105Bladder diverticulum (HP:0000015)1.80166314
106Joint laxity (HP:0001388)1.80035337
107Distal lower limb muscle weakness (HP:0009053)1.79110730
108Buphthalmos (HP:0000557)1.78441810
109Skin nodule (HP:0200036)1.78331630
110Hemangiomatosis (HP:0007461)1.77216921
111Coronal craniosynostosis (HP:0004440)1.76954250
112Aortic regurgitation (HP:0001659)1.76495095
113Hypoplastic left heart (HP:0004383)1.76435128
114Bronchomalacia (HP:0002780)1.75241728
115Wrist flexion contracture (HP:0001239)1.74771719
116Abnormality of the acetabulum (HP:0003170)1.72897123
117Deep venous thrombosis (HP:0002625)1.72394364
118Aortic dissection (HP:0002647)1.72252030
119Atonic seizures (HP:0010819)1.71971648
120Facial diplegia (HP:0001349)1.71605988
121Focal seizures (HP:0007359)1.71486294
122Hypoalphalipoproteinemia (HP:0003233)1.70950478
123Nephritis (HP:0000123)1.70818069
124Adactyly (HP:0009776)1.69347414
125Biconcave vertebral bodies (HP:0004586)1.69016602
126Hamartoma of the eye (HP:0010568)1.68677991
127Glomerulonephritis (HP:0000099)1.68408745
128Action tremor (HP:0002345)1.68113659
129Lower limb amyotrophy (HP:0007210)1.67659241
130Sudden cardiac death (HP:0001645)1.67622991
131Proximal amyotrophy (HP:0007126)1.67239543
132Cavernous hemangioma (HP:0001048)1.66431535
133Ectopia lentis (HP:0001083)1.65382993
134Hip contracture (HP:0003273)1.64803356
135Abnormal delivery (HP:0001787)1.63984966
136Peritonitis (HP:0002586)1.62761977
137Neurofibrillary tangles (HP:0002185)1.62347969
138Pulmonary artery stenosis (HP:0004415)1.62064280
139Distal lower limb amyotrophy (HP:0008944)1.60849005
140Aplasia involving bones of the upper limbs (HP:0009823)1.59879386
141Aplasia of the phalanges of the hand (HP:0009802)1.59879386
142Aplasia involving bones of the extremities (HP:0009825)1.59879386
143Limb-girdle muscle atrophy (HP:0003797)1.58805008
144Rhabdomyolysis (HP:0003201)1.56746287
145Atrophic scars (HP:0001075)1.56104421
146Hypoglycemic seizures (HP:0002173)1.56047172
147Congestive heart failure (HP:0001635)1.54488271
148Venous abnormality (HP:0002624)1.53617757
149Short hallux (HP:0010109)1.52784727

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.26734736
2TTN3.17226733
3LMTK22.74180483
4KDR2.65000290
5DMPK2.54065395
6RIPK12.50354424
7PHKG12.43665680
8PHKG22.43665680
9TRIB32.42859768
10MYLK2.11121897
11TGFBR22.01723365
12CAMK1G1.77673758
13MARK11.74150186
14INSRR1.70620982
15PDK31.69960048
16PDK41.69960048
17STK38L1.69934279
18OBSCN1.69629118
19NEK91.67176029
20PRKD31.66197267
21PKN21.61724236
22PAK31.52573846
23TRPM71.51603318
24PDGFRA1.50940064
25FER1.50633208
26CAMK1D1.50371148
27PTK2B1.47446337
28PDK21.42485070
29ICK1.39128436
30EPHB21.30475901
31FGFR21.30213198
32NTRK31.24922636
33PRKD11.24788530
34PIK3CA1.23609010
35PAK21.21555226
36MOS1.15099777
37MAP3K41.13026443
38FGFR41.11777887
39MAP3K61.11027109
40PIK3CG1.09846482
41DDR21.08246631
42PRKCH1.06812480
43PTK61.04302065
44WNK11.00810955
45SIK10.98393927
46PAK60.95900466
47EEF2K0.94548806
48ROCK10.93912915
49MAPK120.93811901
50WNK40.93099525
51PRKCE0.92654586
52CDC42BPA0.92136599
53NTRK10.90712084
54EPHA20.90207686
55EPHB10.88800201
56MTOR0.88597700
57CASK0.88198304
58PRKAA20.87321148
59STK380.83168845
60RET0.80647827
61LATS20.78775039
62PINK10.77153823
63CAMK2D0.76928019
64CAMKK20.76924554
65MAPK70.75605458
66PRKG20.75348368
67STK240.75113858
68PDGFRB0.74490806
69TESK10.74302475
70GRK70.73033891
71CAMK2B0.72438111
72CAMK40.72317199
73ERBB40.71953364
74MST1R0.71897228
75PRKAA10.71667393
76MAP2K40.71432134
77LATS10.70228270
78CAMK10.69553307
79CAMK2A0.68865948
80MARK20.68833131
81FGFR30.68570421
82PTK20.67978656
83NTRK20.66713307
84ROCK20.66554175
85MAP3K90.66241265
86RPS6KA20.64692501
87CAMKK10.64523560
88LIMK10.64070537
89MAP3K120.63464530
90TAOK10.62810831
91ILK0.62031441
92SGK30.61946933
93PDPK10.61902889
94MUSK0.60829874
95TGFBR10.60195496
96EPHA30.60097496
97ERN10.59812557
98TYRO30.59123570
99DAPK20.56268622
100BMX0.55977191
101SGK20.55652934
102MET0.55551410
103KSR20.55447522
104CDK50.54662128
105MAP3K70.54203986
106CAMK2G0.53414295
107GRK50.52474195
108AKT30.52242588
109MARK30.52007895
110MAP3K10.51767592
111MAPKAPK30.51048956
112CDK120.50796875
113MAP3K130.50013962
114SGK4940.49296955
115SGK2230.49296955
116PRKD20.49238729
117PRKG10.49204671
118MAP2K10.49162173
119MAP3K30.48845902
120FLT30.47846656
121MINK10.46447897
122STK110.44377374
123GSK3A0.44335685
124MAPK40.43027560
125SGK10.42294164
126IGF1R0.41844913
127EPHA40.41807297
128DAPK30.41361869
129SRC0.40822460
130PAK40.38623868
131PRKACB0.37687837

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054142.75873712
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.65342596
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.42645752
4Cardiac muscle contraction_Homo sapiens_hsa042602.13213767
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.04793873
6Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77520037
7Complement and coagulation cascades_Homo sapiens_hsa046101.71763819
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.66457439
9ECM-receptor interaction_Homo sapiens_hsa045121.57995299
10Focal adhesion_Homo sapiens_hsa045101.49992565
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.49373068
12Insulin secretion_Homo sapiens_hsa049111.47464951
13GABAergic synapse_Homo sapiens_hsa047271.47321800
14Circadian entrainment_Homo sapiens_hsa047131.46934892
15Renin secretion_Homo sapiens_hsa049241.45445556
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41937536
17Gastric acid secretion_Homo sapiens_hsa049711.39967963
18cGMP-PKG signaling pathway_Homo sapiens_hsa040221.35694631
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29707454
20Salivary secretion_Homo sapiens_hsa049701.28683865
21Propanoate metabolism_Homo sapiens_hsa006401.28476736
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28319098
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27957630
24Morphine addiction_Homo sapiens_hsa050321.23834914
25Oxytocin signaling pathway_Homo sapiens_hsa049211.21387112
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.20089480
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17880175
28Dorso-ventral axis formation_Homo sapiens_hsa043201.15462167
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13493633
30Taste transduction_Homo sapiens_hsa047421.12470133
31Glutamatergic synapse_Homo sapiens_hsa047241.11574614
32Calcium signaling pathway_Homo sapiens_hsa040201.11553719
33cAMP signaling pathway_Homo sapiens_hsa040241.10832377
34Type II diabetes mellitus_Homo sapiens_hsa049301.08632424
35Long-term potentiation_Homo sapiens_hsa047201.08386210
36Gap junction_Homo sapiens_hsa045401.07518921
37Cholinergic synapse_Homo sapiens_hsa047251.06888922
38* Adherens junction_Homo sapiens_hsa045201.05834510
39Small cell lung cancer_Homo sapiens_hsa052221.05664765
40Fatty acid metabolism_Homo sapiens_hsa012121.04078643
41Estrogen signaling pathway_Homo sapiens_hsa049151.03525128
42Melanogenesis_Homo sapiens_hsa049161.03352602
43Fatty acid degradation_Homo sapiens_hsa000711.02471324
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00403537
45Nicotine addiction_Homo sapiens_hsa050330.97856550
46Olfactory transduction_Homo sapiens_hsa047400.95807745
47Insulin resistance_Homo sapiens_hsa049310.94867766
48Rap1 signaling pathway_Homo sapiens_hsa040150.94285172
49Butanoate metabolism_Homo sapiens_hsa006500.94166347
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.94087630
51Glucagon signaling pathway_Homo sapiens_hsa049220.94014365
52GnRH signaling pathway_Homo sapiens_hsa049120.93959806
53Viral myocarditis_Homo sapiens_hsa054160.92925417
54Prion diseases_Homo sapiens_hsa050200.92745894
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91574004
56Phenylalanine metabolism_Homo sapiens_hsa003600.91010557
57Dopaminergic synapse_Homo sapiens_hsa047280.90886446
58Synaptic vesicle cycle_Homo sapiens_hsa047210.90451261
59Axon guidance_Homo sapiens_hsa043600.90412493
60Tight junction_Homo sapiens_hsa045300.89601064
61Amphetamine addiction_Homo sapiens_hsa050310.89250954
62Fatty acid biosynthesis_Homo sapiens_hsa000610.88141564
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88117460
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87857316
65Pancreatic secretion_Homo sapiens_hsa049720.86060446
66Nitrogen metabolism_Homo sapiens_hsa009100.84882080
67Renal cell carcinoma_Homo sapiens_hsa052110.84662558
68Long-term depression_Homo sapiens_hsa047300.84281192
69Hippo signaling pathway_Homo sapiens_hsa043900.82284986
70Histidine metabolism_Homo sapiens_hsa003400.82202373
71Amoebiasis_Homo sapiens_hsa051460.81507293
72Proteoglycans in cancer_Homo sapiens_hsa052050.81108786
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79175772
74Insulin signaling pathway_Homo sapiens_hsa049100.79070110
75Arginine biosynthesis_Homo sapiens_hsa002200.78353057
76PPAR signaling pathway_Homo sapiens_hsa033200.78311739
77Cocaine addiction_Homo sapiens_hsa050300.77971279
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75572508
79Alzheimers disease_Homo sapiens_hsa050100.74831552
80Serotonergic synapse_Homo sapiens_hsa047260.73965898
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.73771833
82ABC transporters_Homo sapiens_hsa020100.73561729
83Protein digestion and absorption_Homo sapiens_hsa049740.73056356
84TGF-beta signaling pathway_Homo sapiens_hsa043500.72420510
85AMPK signaling pathway_Homo sapiens_hsa041520.71747225
86Bile secretion_Homo sapiens_hsa049760.70041881
87Thyroid hormone synthesis_Homo sapiens_hsa049180.69209324
88Ovarian steroidogenesis_Homo sapiens_hsa049130.68848911
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68838154
90Parkinsons disease_Homo sapiens_hsa050120.67148880
91Platelet activation_Homo sapiens_hsa046110.66661887
92HIF-1 signaling pathway_Homo sapiens_hsa040660.66153293
93Circadian rhythm_Homo sapiens_hsa047100.64894991
94Lysine degradation_Homo sapiens_hsa003100.64736906
95Glycerolipid metabolism_Homo sapiens_hsa005610.64659804
96Tyrosine metabolism_Homo sapiens_hsa003500.63905572
97Ras signaling pathway_Homo sapiens_hsa040140.63692551
98Oxidative phosphorylation_Homo sapiens_hsa001900.63526783
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62942351
100Pathways in cancer_Homo sapiens_hsa052000.62037539
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.61285541
102Glioma_Homo sapiens_hsa052140.60846788
103Hedgehog signaling pathway_Homo sapiens_hsa043400.60352986
104VEGF signaling pathway_Homo sapiens_hsa043700.57967297
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56708437
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55412997
107Basal cell carcinoma_Homo sapiens_hsa052170.54879374
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54220001
109Arginine and proline metabolism_Homo sapiens_hsa003300.53630398
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53056291
111* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52579076
112MAPK signaling pathway_Homo sapiens_hsa040100.52235993
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51170135
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51111660
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.50859773
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50133381
117beta-Alanine metabolism_Homo sapiens_hsa004100.48041895
118Vibrio cholerae infection_Homo sapiens_hsa051100.47664650
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46851388
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46294874
121Melanoma_Homo sapiens_hsa052180.45781910

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