PTPN7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.46831829
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.46831829
3positive regulation of gamma-delta T cell activation (GO:0046645)5.14714098
4cytidine deamination (GO:0009972)5.13204893
5cytidine metabolic process (GO:0046087)5.13204893
6cytidine catabolic process (GO:0006216)5.13204893
7antigen processing and presentation of endogenous antigen (GO:0019883)4.71275956
8pyrimidine ribonucleoside catabolic process (GO:0046133)4.69478316
9ribosomal small subunit assembly (GO:0000028)4.60139238
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.33895522
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.30597611
12negative regulation of phagocytosis (GO:0050765)3.98878406
13Arp2/3 complex-mediated actin nucleation (GO:0034314)3.93640476
14leukocyte aggregation (GO:0070486)3.93433373
15positive regulation of B cell differentiation (GO:0045579)3.90835349
16regulation of gamma-delta T cell differentiation (GO:0045586)3.89128117
17regulation of B cell receptor signaling pathway (GO:0050855)3.86995271
18DNA strand elongation involved in DNA replication (GO:0006271)3.69520654
19telomere maintenance via semi-conservative replication (GO:0032201)3.64861454
20mast cell activation (GO:0045576)3.64100146
21DNA unwinding involved in DNA replication (GO:0006268)3.62860745
22regulation of gamma-delta T cell activation (GO:0046643)3.62689700
23viral transcription (GO:0019083)3.59722058
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.58583719
25regulation of regulatory T cell differentiation (GO:0045589)3.56985214
26negative T cell selection (GO:0043383)3.56836134
27DNA strand elongation (GO:0022616)3.54652244
28positive regulation of defense response to virus by host (GO:0002230)3.52159302
29Peyers patch development (GO:0048541)3.47661097
30mucosal-associated lymphoid tissue development (GO:0048537)3.47661097
31regulation of alpha-beta T cell proliferation (GO:0046640)3.47233654
32negative thymic T cell selection (GO:0045060)3.47161936
33regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.46698154
34regulation of natural killer cell mediated immunity (GO:0002715)3.46698154
35translational termination (GO:0006415)3.45978281
36regulation of B cell differentiation (GO:0045577)3.42351872
37T cell homeostasis (GO:0043029)3.40903039
38regulation of lymphocyte chemotaxis (GO:1901623)3.40899019
39regulation of activation of Janus kinase activity (GO:0010533)3.39473240
40positive regulation of natural killer cell mediated immunity (GO:0002717)3.30144798
41regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.29292133
42positive regulation of alpha-beta T cell proliferation (GO:0046641)3.28378818
43antigen processing and presentation via MHC class Ib (GO:0002475)3.27590788
44interferon-gamma production (GO:0032609)3.24380538
45telomere maintenance via recombination (GO:0000722)3.23412900
46negative regulation of T cell mediated immunity (GO:0002710)3.22389757
47response to interleukin-15 (GO:0070672)3.19605310
48positive thymic T cell selection (GO:0045059)3.18673600
49negative regulation of T cell apoptotic process (GO:0070233)3.18316239
50positive regulation of lymphocyte migration (GO:2000403)3.18100964
51B cell receptor signaling pathway (GO:0050853)3.17607789
52regulation of T cell tolerance induction (GO:0002664)3.16040826
53T cell migration (GO:0072678)3.15164562
54positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.12998334
55negative regulation by host of viral transcription (GO:0043922)3.10314592
56DNA deamination (GO:0045006)3.09936926
57negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.09920238
58negative regulation of cell killing (GO:0031342)3.09920238
59positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.09488179
60DNA replication initiation (GO:0006270)3.09167161
61regulation of chronic inflammatory response (GO:0002676)3.09124878
62mast cell activation involved in immune response (GO:0002279)3.08221323
63mast cell degranulation (GO:0043303)3.08221323
64tolerance induction (GO:0002507)3.07424825
65regulation of leukocyte mediated cytotoxicity (GO:0001910)3.06941242
66SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.06904478
67translational elongation (GO:0006414)3.06057612
68regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.02386612
69activated T cell proliferation (GO:0050798)3.01454900
70mitotic recombination (GO:0006312)3.01113581
71natural killer cell differentiation (GO:0001779)3.00675384
72positive regulation of granulocyte differentiation (GO:0030854)3.00623758
73ribosomal small subunit biogenesis (GO:0042274)3.00445503
74granulocyte activation (GO:0036230)2.99957744
75positive regulation of T cell mediated cytotoxicity (GO:0001916)2.98982481
76cotranslational protein targeting to membrane (GO:0006613)2.98875777
77positive regulation of calcium-mediated signaling (GO:0050850)2.98710857
78positive regulation of tolerance induction (GO:0002645)2.98387281
79protein targeting to ER (GO:0045047)2.97914861
80regulation of T cell mediated cytotoxicity (GO:0001914)2.97172884
81regulation of interleukin-12 biosynthetic process (GO:0045075)2.96953511
82megakaryocyte development (GO:0035855)2.96896143
83actin nucleation (GO:0045010)2.95936221
84positive regulation of cell killing (GO:0031343)2.91480517
85regulation of tolerance induction (GO:0002643)2.91419396
86regulation of T cell receptor signaling pathway (GO:0050856)2.91327197
87regulation of granulocyte differentiation (GO:0030852)2.89634165
88natural killer cell activation (GO:0030101)2.89221852
89negative regulation of lymphocyte mediated immunity (GO:0002707)2.88910856
90positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.88311684
91regulation of cell killing (GO:0031341)2.88305773
92lymphocyte migration (GO:0072676)2.86520938
93regulation of isotype switching to IgG isotypes (GO:0048302)2.86192209
94nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.85736764
95regulation of lymphocyte migration (GO:2000401)2.84748777
96establishment of protein localization to endoplasmic reticulum (GO:0072599)2.84324690
97definitive hemopoiesis (GO:0060216)2.83991413
98negative regulation of leukocyte mediated immunity (GO:0002704)2.83766534
99neutrophil activation (GO:0042119)2.83735457
100lymphocyte chemotaxis (GO:0048247)2.81934268
101positive regulation of interleukin-2 production (GO:0032743)2.81392488
102lymph node development (GO:0048535)2.80841539
103protein localization to endoplasmic reticulum (GO:0070972)2.80110477
104positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.80082761
105lymphocyte homeostasis (GO:0002260)2.79953174
106positive T cell selection (GO:0043368)2.79900682
107thymic T cell selection (GO:0045061)2.79163489
108positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.78918955
109positive regulation of T cell chemotaxis (GO:0010820)2.78798216
110regulation of T cell chemotaxis (GO:0010819)2.78798216
111respiratory burst (GO:0045730)2.78268851
112negative regulation of viral genome replication (GO:0045071)2.76505547
113cellular response to interleukin-15 (GO:0071350)2.75168791
114antigen receptor-mediated signaling pathway (GO:0050851)2.74544928
115regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.74217511
116T cell selection (GO:0045058)2.71345874
117viral life cycle (GO:0019058)2.71134898
118maturation of SSU-rRNA (GO:0030490)2.70644967
119immunoglobulin mediated immune response (GO:0016064)2.69605607
120myeloid dendritic cell activation (GO:0001773)2.68459841
121positive regulation of macrophage differentiation (GO:0045651)2.68027698
122response to protozoan (GO:0001562)2.66419928
123cellular protein complex disassembly (GO:0043624)2.64667422
124nucleotide-excision repair, DNA gap filling (GO:0006297)2.64072429
125negative regulation of erythrocyte differentiation (GO:0045647)2.63917765
126telomere maintenance via telomere lengthening (GO:0010833)2.63206081
127T cell receptor signaling pathway (GO:0050852)2.62085367
128translational initiation (GO:0006413)2.59996389
129neutrophil activation involved in immune response (GO:0002283)2.57954170
130regulation of necroptotic process (GO:0060544)2.57176918
131positive regulation of isotype switching (GO:0045830)2.56310680
132defense response to protozoan (GO:0042832)2.55868207
133NIK/NF-kappaB signaling (GO:0038061)2.55439271
134translesion synthesis (GO:0019985)2.51405564
135neutrophil mediated immunity (GO:0002446)2.50845569
136leukocyte degranulation (GO:0043299)2.50550045
137leukocyte homeostasis (GO:0001776)2.50389595
138positive regulation of lamellipodium assembly (GO:0010592)2.48846923
139B cell mediated immunity (GO:0019724)2.46233513
140regulation of erythrocyte differentiation (GO:0045646)2.46144924
141negative regulation of interleukin-12 production (GO:0032695)2.45362344
142protein localization to kinetochore (GO:0034501)2.45075729
143T cell costimulation (GO:0031295)2.43938122
144cellular response to zinc ion (GO:0071294)2.43804574
145lymphocyte costimulation (GO:0031294)2.42690966
146regulation of interleukin-2 biosynthetic process (GO:0045076)2.42656994
147protein complex disassembly (GO:0043241)2.41690918
148pinocytosis (GO:0006907)2.40986237
149response to fungus (GO:0009620)2.40530723
150cellular extravasation (GO:0045123)2.40387820
151IMP metabolic process (GO:0046040)2.40266341
152negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.40233006

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.88233419
2* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.04989329
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.00784673
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.98870679
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.96397850
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.93590311
7SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.78395837
8* MYC_22102868_ChIP-Seq_BL_Human2.78255967
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.76791612
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.74821832
11SCL_19346495_ChIP-Seq_HPC-7_Human2.73643018
12* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.67702172
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.63394360
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.60060569
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.57727880
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.55371174
17* VDR_21846776_ChIP-Seq_THP-1_Human2.54533472
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.47905526
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.40948464
20* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.31433721
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.29627876
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.21450167
23* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.18939095
24* SPI1_23547873_ChIP-Seq_NB4_Human2.17411453
25* MYB_26560356_Chip-Seq_TH2_Human2.15650878
26* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.13983357
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.04268116
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.03952954
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.00187836
30* MAF_26560356_Chip-Seq_TH1_Human1.92259321
31* MYB_26560356_Chip-Seq_TH1_Human1.88352189
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.87616104
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.87088061
34* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.85632618
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83399598
36VDR_24763502_ChIP-Seq_THP-1_Human1.82934983
37* UTX_26944678_Chip-Seq_JUKART_Human1.81528036
38* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81485886
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79160747
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.78263038
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77983282
42VDR_23849224_ChIP-Seq_CD4+_Human1.77582700
43CIITA_25753668_ChIP-Seq_RAJI_Human1.77438530
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.75657933
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75269704
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70675696
47* GATA3_26560356_Chip-Seq_TH2_Human1.70013510
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.69730802
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.69584017
50FOXP3_21729870_ChIP-Seq_TREG_Human1.68701323
51RUNX_20019798_ChIP-Seq_JUKART_Human1.63395756
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.63334653
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60691874
54* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57414893
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.57069884
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.49452779
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.49327076
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49216047
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48812145
60* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.48498189
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48173445
62TCF7_22412390_ChIP-Seq_EML_Mouse1.47617693
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44148969
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.43581688
65XRN2_22483619_ChIP-Seq_HELA_Human1.42819584
66* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.39564118
67KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38938812
68* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36143804
69* MAF_26560356_Chip-Seq_TH2_Human1.33634208
70* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33503817
71* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.33392824
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32021503
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27702125
74SPI1_23127762_ChIP-Seq_K562_Human1.25918980
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25778522
76ELK1_19687146_ChIP-ChIP_HELA_Human1.21430899
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19533707
78CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19369394
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.18252698
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18018773
81GABP_19822575_ChIP-Seq_HepG2_Human1.14066750
82NELFA_20434984_ChIP-Seq_ESCs_Mouse1.13895478
83DCP1A_22483619_ChIP-Seq_HELA_Human1.12976142
84* GATA3_27048872_Chip-Seq_THYMUS_Human1.12288630
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11889101
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10515961
87GATA1_22025678_ChIP-Seq_K562_Human1.09596078
88RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09144440
89* PU_27001747_Chip-Seq_BMDM_Mouse1.08729269
90BCL6_27268052_Chip-Seq_Bcells_Human1.08394254
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06776852
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05041907
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04562368
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04003657
95TTF2_22483619_ChIP-Seq_HELA_Human1.03804027
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03368278
97VDR_24787735_ChIP-Seq_THP-1_Human1.01628071
98* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99353403
99KDM5A_27292631_Chip-Seq_BREAST_Human0.98035676
100KDM2B_26808549_Chip-Seq_DND41_Human0.97160501
101CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97019859
102TFEB_21752829_ChIP-Seq_HELA_Human0.95224258
103GATA1_19941826_ChIP-Seq_K562_Human0.95169210
104GATA1_19941827_ChIP-Seq_MEL_Mouse0.94947395
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94300737
106BCOR_27268052_Chip-Seq_Bcells_Human0.94061903
107SRF_21415370_ChIP-Seq_HL-1_Mouse0.93657812
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93199224
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92589247
110CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.92008741
111PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91482036
112HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91443037
113* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91414961
114NCOR1_26117541_ChIP-Seq_K562_Human0.89040434
115PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88518814
116P300_27268052_Chip-Seq_Bcells_Human0.88344840
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88297897
118RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87783926
119CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87688357
120CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85795936
121VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85538565
122* GATA3_26560356_Chip-Seq_TH1_Human0.84386547
123E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.81919921
124CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80261694

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.77707029
2MP0001835_abnormal_antigen_presentation3.58148632
3MP0003763_abnormal_thymus_physiology3.39686724
4MP0005671_abnormal_response_to3.18462010
5MP0000685_abnormal_immune_system2.83737482
6MP0001800_abnormal_humoral_immune2.75777162
7MP0009785_altered_susceptibility_to2.69643354
8MP0002398_abnormal_bone_marrow2.65418731
9MP0003436_decreased_susceptibility_to2.65146990
10MP0005000_abnormal_immune_tolerance2.55249642
11MP0002420_abnormal_adaptive_immunity2.53978499
12MP0001819_abnormal_immune_cell2.50701810
13MP0005025_abnormal_response_to2.49406775
14MP0002452_abnormal_antigen_presenting2.47685388
15MP0002723_abnormal_immune_serum2.44439427
16MP0001790_abnormal_immune_system2.41903596
17MP0005387_immune_system_phenotype2.41903596
18MP0002166_altered_tumor_susceptibility2.41253513
19MP0009333_abnormal_splenocyte_physiolog2.40087149
20MP0004808_abnormal_hematopoietic_stem2.37687299
21MP0005464_abnormal_platelet_physiology2.32776313
22MP0002419_abnormal_innate_immunity2.29453979
23MP0010094_abnormal_chromosome_stability2.26449099
24MP0000716_abnormal_immune_system2.26183189
25MP0005397_hematopoietic_system_phenotyp2.25256194
26MP0001545_abnormal_hematopoietic_system2.25256194
27MP0000689_abnormal_spleen_morphology2.21232842
28MP0002722_abnormal_immune_system2.21066066
29MP0003303_peritoneal_inflammation2.18850874
30MP0008057_abnormal_DNA_replication2.17209107
31MP0003693_abnormal_embryo_hatching2.17051177
32MP0002405_respiratory_system_inflammati2.10937401
33MP0000703_abnormal_thymus_morphology2.06648892
34MP0002148_abnormal_hypersensitivity_rea2.05855882
35MP0003724_increased_susceptibility_to2.05053803
36MP0000465_gastrointestinal_hemorrhage2.02752926
37MP0002429_abnormal_blood_cell2.01094811
38MP0002006_tumorigenesis1.97211789
39MP0000490_abnormal_crypts_of1.96449299
40MP0001873_stomach_inflammation1.94475037
41MP0005174_abnormal_tail_pigmentation1.94156869
42MP0010155_abnormal_intestine_physiology1.89362717
43MP0003111_abnormal_nucleus_morphology1.83845837
44MP0001853_heart_inflammation1.76947020
45MP0003300_gastrointestinal_ulcer1.72803048
46MP0003866_abnormal_defecation1.72114559
47MP0003077_abnormal_cell_cycle1.71035306
48MP0006082_CNS_inflammation1.66564348
49MP0001845_abnormal_inflammatory_respons1.61059339
50MP0005075_abnormal_melanosome_morpholog1.53723621
51MP0009278_abnormal_bone_marrow1.50241789
52MP0004957_abnormal_blastocyst_morpholog1.46046817
53MP0008058_abnormal_DNA_repair1.44062819
54MP0004947_skin_inflammation1.38615412
55MP0002019_abnormal_tumor_incidence1.35045184
56MP0008007_abnormal_cellular_replicative1.33414968
57MP0000858_altered_metastatic_potential1.30727977
58MP0010307_abnormal_tumor_latency1.28232177
59MP0003172_abnormal_lysosome_physiology1.26172215
60MP0002095_abnormal_skin_pigmentation1.24849190
61MP0002933_joint_inflammation1.23760769
62MP0000015_abnormal_ear_pigmentation1.22028425
63MP0002009_preneoplasia1.18810588
64MP0008469_abnormal_protein_level1.17244729
65MP0001533_abnormal_skeleton_physiology1.17234003
66MP0005310_abnormal_salivary_gland1.11250516
67MP0002132_abnormal_respiratory_system1.08898375
68MP0003656_abnormal_erythrocyte_physiolo1.08789852
69MP0002138_abnormal_hepatobiliary_system1.02870375
70MP0003045_fibrosis1.01792361
71MP0005058_abnormal_lysosome_morphology1.00507646
72MP0010352_gastrointestinal_tract_polyps0.99828363
73MP0003183_abnormal_peptide_metabolism0.99209311
74MP0000313_abnormal_cell_death0.97497473
75MP0006054_spinal_hemorrhage0.94456198
76MP0003448_altered_tumor_morphology0.93968521
77MP0002163_abnormal_gland_morphology0.90874608
78MP0001851_eye_inflammation0.87980910
79MP0001986_abnormal_taste_sensitivity0.80070096
80MP0000343_altered_response_to0.79817370
81MP0004510_myositis0.79699481
82MP0001663_abnormal_digestive_system0.78734543
83MP0000350_abnormal_cell_proliferation0.77758927
84MP0000372_irregular_coat_pigmentation0.71767265
85MP0009763_increased_sensitivity_to0.71672536
86MP0009764_decreased_sensitivity_to0.70280380
87MP0004147_increased_porphyrin_level0.69044118
88MP0000604_amyloidosis0.67665596
89MP0002877_abnormal_melanocyte_morpholog0.67488226
90MP0003786_premature_aging0.66171249
91MP0003075_altered_response_to0.62107947
92MP0002693_abnormal_pancreas_physiology0.60314028
93MP0004381_abnormal_hair_follicle0.59691803
94MP0000477_abnormal_intestine_morphology0.59411182
95MP0008873_increased_physiological_sensi0.57900546
96MP0005409_darkened_coat_color0.56086331
97MP0000609_abnormal_liver_physiology0.56065708
98MP0005645_abnormal_hypothalamus_physiol0.55329328
99MP0002277_abnormal_respiratory_mucosa0.54890641
100MP0002998_abnormal_bone_remodeling0.54657092
101MP0005166_decreased_susceptibility_to0.53113430
102MP0000569_abnormal_digit_pigmentation0.53029640
103MP0003943_abnormal_hepatobiliary_system0.52859812
104MP0001730_embryonic_growth_arrest0.52624899
105MP0006036_abnormal_mitochondrial_physio0.52467053
106MP0001919_abnormal_reproductive_system0.51020160
107MP0005076_abnormal_cell_differentiation0.50797598
108MP0002083_premature_death0.50514193
109MP0009765_abnormal_xenobiotic_induced0.50073842
110MP0009840_abnormal_foam_cell0.49868439
111MP0005379_endocrine/exocrine_gland_phen0.49398998
112MP0000371_diluted_coat_color0.48491050
113MP0003795_abnormal_bone_structure0.48330779
114MP0003806_abnormal_nucleotide_metabolis0.47978179
115MP0000598_abnormal_liver_morphology0.45910024
116MP0002080_prenatal_lethality0.45442130
117MP0008877_abnormal_DNA_methylation0.45165398
118MP0000249_abnormal_blood_vessel0.44952330
119MP0003191_abnormal_cellular_cholesterol0.44400223
120MP0003828_pulmonary_edema0.44318777

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)4.61717077
2Chronic otitis media (HP:0000389)4.44776800
3Thrombocytosis (HP:0001894)4.42710883
4Recurrent abscess formation (HP:0002722)4.41382826
5Eczematoid dermatitis (HP:0000976)4.25665319
6Elevated erythrocyte sedimentation rate (HP:0003565)4.23621767
7Recurrent viral infections (HP:0004429)4.21669544
8Recurrent fungal infections (HP:0002841)4.09467614
9Panhypogammaglobulinemia (HP:0003139)4.00042482
10Myositis (HP:0100614)3.85193628
11Petechiae (HP:0000967)3.82573979
12Recurrent bacterial skin infections (HP:0005406)3.78975690
13T lymphocytopenia (HP:0005403)3.72835791
14B lymphocytopenia (HP:0010976)3.69033005
15Abnormality of B cell number (HP:0010975)3.69033005
16Abnormality of T cells (HP:0002843)3.68024414
17Recurrent bronchitis (HP:0002837)3.65075114
18Abnormal number of erythroid precursors (HP:0012131)3.60166442
19Abnormality of cells of the erythroid lineage (HP:0012130)3.54321186
20Abnormality of T cell number (HP:0011839)3.53798426
21Meningitis (HP:0001287)3.48841398
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.48764390
23Abnormality of T cell physiology (HP:0011840)3.46349609
24Prolonged bleeding time (HP:0003010)3.38942079
25Increased IgM level (HP:0003496)3.38061264
26Obstructive lung disease (HP:0006536)3.25063536
27Chronic obstructive pulmonary disease (HP:0006510)3.25063536
28Recurrent cutaneous fungal infections (HP:0011370)3.24187614
29Chronic mucocutaneous candidiasis (HP:0002728)3.24187614
30Reticulocytopenia (HP:0001896)3.20060548
31Cellulitis (HP:0100658)3.04924691
32Severe combined immunodeficiency (HP:0004430)3.03168737
33Recurrent skin infections (HP:0001581)3.01899764
34IgG deficiency (HP:0004315)3.01181915
35Nasal polyposis (HP:0100582)2.99851374
36Gastrointestinal infarctions (HP:0005244)2.98994612
37Mediastinal lymphadenopathy (HP:0100721)2.92556327
38Eosinophilia (HP:0001880)2.89433958
39Abnormality of the prostate (HP:0008775)2.88050006
40Granulocytopenia (HP:0001913)2.87943016
41Aplastic anemia (HP:0001915)2.80994495
42Epistaxis (HP:0000421)2.80290455
43Lymphopenia (HP:0001888)2.79847247
44Combined immunodeficiency (HP:0005387)2.78982210
45Thyroiditis (HP:0100646)2.77645908
46Abnormality of cells of the lymphoid lineage (HP:0012140)2.74115501
47Leukocytosis (HP:0001974)2.71191792
48Agammaglobulinemia (HP:0004432)2.70227645
49Lymphoma (HP:0002665)2.68701666
50Abnormality of eosinophils (HP:0001879)2.66838488
51Inflammation of the large intestine (HP:0002037)2.63968112
52Gastrointestinal inflammation (HP:0004386)2.63126691
53Vasculitis (HP:0002633)2.61986333
54Abnormality of the fingertips (HP:0001211)2.60830832
55Abnormality of the nasal mucosa (HP:0000433)2.60168917
56Stomatitis (HP:0010280)2.59308157
57Joint swelling (HP:0001386)2.53908441
58Abnormal platelet function (HP:0011869)2.53402168
59Impaired platelet aggregation (HP:0003540)2.53402168
60Retrobulbar optic neuritis (HP:0100654)2.52378915
61Optic neuritis (HP:0100653)2.52378915
62Abnormality of macrophages (HP:0004311)2.51610509
63Keratoconjunctivitis (HP:0001096)2.51563061
64Encephalitis (HP:0002383)2.50372524
65Spontaneous hematomas (HP:0007420)2.49781678
66Hypoplasia of the thymus (HP:0000778)2.49386292
67Orchitis (HP:0100796)2.48720230
68Pustule (HP:0200039)2.47608352
69Gangrene (HP:0100758)2.39431015
70Abnormality of male internal genitalia (HP:0000022)2.38768032
71Recurrent gram-negative bacterial infections (HP:0005420)2.38566942
72Abnormal platelet volume (HP:0011876)2.38257079
73Myelodysplasia (HP:0002863)2.37012203
74Pallor (HP:0000980)2.36278294
75Pulmonary embolism (HP:0002204)2.34561696
76Acute myeloid leukemia (HP:0004808)2.31720923
77Poikiloderma (HP:0001029)2.31367732
78Periodontitis (HP:0000704)2.30559012
79Skin rash (HP:0000988)2.30211903
80Abnormality of the pleura (HP:0002103)2.29753895
81Increased neuronal autofluorescent lipopigment (HP:0002074)2.29718650
82Chest pain (HP:0100749)2.29514632
83IgA deficiency (HP:0002720)2.29424993
84Hemoptysis (HP:0002105)2.27620899
85Osteomyelitis (HP:0002754)2.23663190
86Increased IgE level (HP:0003212)2.21792073
87Urticaria (HP:0001025)2.18862970
88Autoimmune thrombocytopenia (HP:0001973)2.18371132
89Amaurosis fugax (HP:0100576)2.17629494
90Hypochromic anemia (HP:0001931)2.15437265
91Prostate neoplasm (HP:0100787)2.15119547
92Gingival bleeding (HP:0000225)2.14308274
93Chromsome breakage (HP:0040012)2.13577534
94Colitis (HP:0002583)2.12808210
95Chronic diarrhea (HP:0002028)2.10961282
96Gastrointestinal stroma tumor (HP:0100723)2.10379171
97Polyneuropathy (HP:0001271)2.06634489
98Reduced antithrombin III activity (HP:0001976)2.05761484
99Hypergammaglobulinemia (HP:0010702)2.05599494
100Pulmonary infiltrates (HP:0002113)2.05401611
101Chronic sinusitis (HP:0011109)2.05016378
102Increased cerebral lipofuscin (HP:0011813)2.04843761
103Arterial thrombosis (HP:0004420)2.03078372
104Autoimmune hemolytic anemia (HP:0001890)2.01998982
105Keratoconjunctivitis sicca (HP:0001097)2.00862322
106Neutropenia (HP:0001875)2.00730798
107Papilloma (HP:0012740)1.99859189
108Verrucae (HP:0200043)1.99859189
109Ureteral stenosis (HP:0000071)1.98785944
110Basal cell carcinoma (HP:0002671)1.98676297
111Recurrent sinusitis (HP:0011108)1.98586899
112Anorexia (HP:0002039)1.98287963
113Skin ulcer (HP:0200042)1.97602749
114Abnormality of glycolipid metabolism (HP:0010969)1.97067658
115Abnormality of liposaccharide metabolism (HP:0010968)1.97067658
116Abnormality of glycosphingolipid metabolism (HP:0004343)1.97067658
117Aplasia/Hypoplasia of the thymus (HP:0010515)1.96858958
118Abnormality of DNA repair (HP:0003254)1.96822403
119Vacuolated lymphocytes (HP:0001922)1.96639538
120Pulmonary fibrosis (HP:0002206)1.95415535
121Acute lymphatic leukemia (HP:0006721)1.94901680
122Bronchitis (HP:0012387)1.94755963
123Hypoproteinemia (HP:0003075)1.94316568
124Hepatosplenomegaly (HP:0001433)1.90791799
125Glomerulopathy (HP:0100820)1.90471597
126Ureteral obstruction (HP:0006000)1.86933496
127Seborrheic dermatitis (HP:0001051)1.86571251
128Keratitis (HP:0000491)1.84550031
129Increased serum ferritin (HP:0003281)1.83749887

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.78570436
2TXK3.47794280
3EEF2K2.75735728
4KIT2.50037521
5ZAP702.45484478
6BLK2.44569381
7BTK2.38175948
8TEC2.33207317
9JAK32.28815250
10CDC72.08519675
11NME22.07725093
12IRAK42.06139406
13TYK21.88989543
14STK101.88387537
15SYK1.86987726
16ITK1.81889153
17TAOK31.70446807
18GRK61.67725917
19FES1.63715860
20CLK11.58290023
21WEE11.54146335
22PIM21.53505172
23IKBKE1.49939855
24CSF1R1.46699509
25MAP3K131.43606952
26LCK1.42742840
27TESK21.38324586
28PKN21.38304100
29TBK11.36533720
30BCKDK1.36457447
31NEK21.32960275
32MAP2K31.29951901
33KDR1.26260076
34PRPF4B1.26030031
35PIM11.24799298
36MAP3K141.22428092
37STK161.22144014
38FLT31.19947602
39HCK1.19399635
40LRRK21.18450578
41LYN1.17351552
42* PRKCQ1.15546453
43CDK41.12875181
44SCYL21.07188177
45BMPR21.07175611
46EIF2AK31.06776927
47MAP3K101.04271269
48ATR1.02553285
49TGFBR11.02334072
50ACVR1B1.01653971
51MAP2K20.99824216
52JAK10.99406869
53NUAK10.98457030
54STK40.97341003
55RPS6KB20.95356203
56IKBKB0.95212468
57RPS6KA40.90268340
58EIF2AK10.89586676
59VRK10.88733297
60PASK0.87766264
61CSK0.87659230
62NLK0.87296210
63TNK20.85928381
64SIK20.81897547
65IRAK30.79179960
66BUB10.78911834
67TSSK60.77519044
68BRSK20.75861206
69SRPK10.73196737
70SMG10.71978762
71RIPK40.71181694
72MKNK10.71085928
73MAP2K60.69317927
74JAK20.68162034
75CDK70.67382127
76MAPK120.66588782
77MAPKAPK30.65881936
78PIK3CG0.64746155
79FGFR40.63130430
80MAPK40.62911638
81MAP3K80.62535598
82CAMKK20.61443908
83FGFR30.60952044
84PDK10.60558582
85TRPM70.58361681
86ERN10.58075819
87ADRBK20.57470423
88AURKB0.56267678
89CDK60.55727713
90MAPK110.55073134
91TLK10.54535702
92TRIB30.53294636
93RPS6KA60.53282463
94EPHB10.51917903
95MAP3K120.51156383
96MAP3K70.50280771
97ZAK0.49259257
98TGFBR20.49189309
99HIPK20.49165744
100TAOK20.48909317
101CDK190.48635132
102SIK30.48511430
103MST40.48506210
104GRK70.47121936
105MAP3K110.47022157
106IRAK10.45493418
107FYN0.44284903
108RPS6KL10.44150586
109RPS6KC10.44150586
110MATK0.44022603
111MARK30.43614590
112MAP4K20.43320669
113DYRK30.42557672
114RPS6KA50.42362185
115NEK90.42339239
116ALK0.41304660
117CHUK0.41071765
118CDK120.40819625
119MKNK20.40257907
120DAPK10.38086734
121VRK20.37981938
122CCNB10.37408322
123RAF10.37040457
124* MAPK30.36154953
125MAPKAPK20.34977462
126CHEK10.34955677
127ABL10.31180244
128EIF2AK20.30424141
129MAPK70.29716707
130CAMKK10.26944653
131IGF1R0.25880611
132INSR0.25337477
133FGR0.22062356

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.09153021
2Primary immunodeficiency_Homo sapiens_hsa053403.61971637
3Mismatch repair_Homo sapiens_hsa034302.84414549
4Ribosome_Homo sapiens_hsa030102.74820553
5Base excision repair_Homo sapiens_hsa034102.40944884
6Leishmaniasis_Homo sapiens_hsa051402.14206410
7Homologous recombination_Homo sapiens_hsa034402.05815438
8Measles_Homo sapiens_hsa051622.04624818
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.01138372
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.98986327
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.98191958
12Antigen processing and presentation_Homo sapiens_hsa046121.97662387
13Non-homologous end-joining_Homo sapiens_hsa034501.92388959
14Hematopoietic cell lineage_Homo sapiens_hsa046401.91659445
15Spliceosome_Homo sapiens_hsa030401.88320817
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.87609978
17Rheumatoid arthritis_Homo sapiens_hsa053231.86133223
18B cell receptor signaling pathway_Homo sapiens_hsa046621.84597533
19Nucleotide excision repair_Homo sapiens_hsa034201.77523981
20T cell receptor signaling pathway_Homo sapiens_hsa046601.75537084
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.73061286
22Herpes simplex infection_Homo sapiens_hsa051681.60661929
23Osteoclast differentiation_Homo sapiens_hsa043801.57206936
24Cell cycle_Homo sapiens_hsa041101.50422112
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46170250
26Allograft rejection_Homo sapiens_hsa053301.43852264
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40694624
28Fanconi anemia pathway_Homo sapiens_hsa034601.40125535
29Asthma_Homo sapiens_hsa053101.39968547
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35005914
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.34470623
32One carbon pool by folate_Homo sapiens_hsa006701.34433372
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33504533
34Pyrimidine metabolism_Homo sapiens_hsa002401.30287781
35Legionellosis_Homo sapiens_hsa051341.24348512
36Other glycan degradation_Homo sapiens_hsa005111.22979909
37RNA transport_Homo sapiens_hsa030131.17900367
38Shigellosis_Homo sapiens_hsa051311.17412742
39Acute myeloid leukemia_Homo sapiens_hsa052211.16216924
40Proteasome_Homo sapiens_hsa030501.15927432
41Hepatitis B_Homo sapiens_hsa051611.14270002
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12304959
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11411951
44Apoptosis_Homo sapiens_hsa042101.05157596
45RNA degradation_Homo sapiens_hsa030181.03842550
46Toxoplasmosis_Homo sapiens_hsa051451.02878334
47p53 signaling pathway_Homo sapiens_hsa041151.02794646
48Viral myocarditis_Homo sapiens_hsa054161.02002248
49Influenza A_Homo sapiens_hsa051641.01047628
50Pentose phosphate pathway_Homo sapiens_hsa000301.00747068
51Graft-versus-host disease_Homo sapiens_hsa053321.00696854
52Epstein-Barr virus infection_Homo sapiens_hsa051690.99893515
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97517680
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96375206
55Pertussis_Homo sapiens_hsa051330.95512146
56Tuberculosis_Homo sapiens_hsa051520.95226730
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94611312
58Viral carcinogenesis_Homo sapiens_hsa052030.94113239
59RNA polymerase_Homo sapiens_hsa030200.91281832
60Platelet activation_Homo sapiens_hsa046110.90177620
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89017129
62Chronic myeloid leukemia_Homo sapiens_hsa052200.88131555
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.88120884
64HTLV-I infection_Homo sapiens_hsa051660.86658827
65Chemokine signaling pathway_Homo sapiens_hsa040620.86482001
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80884133
67Malaria_Homo sapiens_hsa051440.78841621
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78269545
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77755396
70Autoimmune thyroid disease_Homo sapiens_hsa053200.77726273
71Systemic lupus erythematosus_Homo sapiens_hsa053220.76093645
72N-Glycan biosynthesis_Homo sapiens_hsa005100.75071370
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74537397
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72647560
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.71410135
76Salmonella infection_Homo sapiens_hsa051320.69882074
77Pancreatic cancer_Homo sapiens_hsa052120.69823288
78African trypanosomiasis_Homo sapiens_hsa051430.68596793
79Staphylococcus aureus infection_Homo sapiens_hsa051500.68107246
80mRNA surveillance pathway_Homo sapiens_hsa030150.67234720
81TNF signaling pathway_Homo sapiens_hsa046680.66863758
82Non-small cell lung cancer_Homo sapiens_hsa052230.61821612
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60508082
84Basal transcription factors_Homo sapiens_hsa030220.59956624
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58378767
86Protein export_Homo sapiens_hsa030600.57860161
87Purine metabolism_Homo sapiens_hsa002300.53936967
88Small cell lung cancer_Homo sapiens_hsa052220.50495741
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50488566
90Colorectal cancer_Homo sapiens_hsa052100.49759931
91Sulfur relay system_Homo sapiens_hsa041220.49580307
92Hepatitis C_Homo sapiens_hsa051600.49161582
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48934123
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45035698
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.44747258
96Thyroid cancer_Homo sapiens_hsa052160.44239648
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43499915
98Type I diabetes mellitus_Homo sapiens_hsa049400.41487188
99Renin-angiotensin system_Homo sapiens_hsa046140.41169753
100VEGF signaling pathway_Homo sapiens_hsa043700.40133717
101Lysosome_Homo sapiens_hsa041420.36847736
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35622722
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.33265860
104HIF-1 signaling pathway_Homo sapiens_hsa040660.33167703
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31733082
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30737135
107Prolactin signaling pathway_Homo sapiens_hsa049170.29714276
108Phagosome_Homo sapiens_hsa041450.27806807
109Notch signaling pathway_Homo sapiens_hsa043300.27729383
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27371582
111Regulation of autophagy_Homo sapiens_hsa041400.23916043
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22365283
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21650111
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.21221710
115Linoleic acid metabolism_Homo sapiens_hsa005910.18710087
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.16015379
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15753443
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.12466818
119Dorso-ventral axis formation_Homo sapiens_hsa043200.11545645
120Endocytosis_Homo sapiens_hsa041440.11222698
121Insulin resistance_Homo sapiens_hsa049310.09475885

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