PTPN5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.75901651
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.71561495
3locomotory exploration behavior (GO:0035641)5.52637062
4synaptic vesicle maturation (GO:0016188)5.49870187
5vocalization behavior (GO:0071625)5.27360394
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.23588103
7regulation of synapse structural plasticity (GO:0051823)5.18336256
8prepulse inhibition (GO:0060134)5.06915241
9synaptic vesicle exocytosis (GO:0016079)4.99585650
10cellular potassium ion homeostasis (GO:0030007)4.93579703
11regulation of glutamate receptor signaling pathway (GO:1900449)4.90043050
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.81003069
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.71864332
14regulation of long-term neuronal synaptic plasticity (GO:0048169)4.65011871
15neurotransmitter-gated ion channel clustering (GO:0072578)4.60685865
16synaptic transmission, dopaminergic (GO:0001963)4.60386304
17regulation of synaptic vesicle exocytosis (GO:2000300)4.51961400
18regulation of neuronal synaptic plasticity (GO:0048168)4.50200682
19sodium ion export (GO:0071436)4.44380656
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.41285696
21protein localization to synapse (GO:0035418)4.38708313
22glutamate secretion (GO:0014047)4.37961451
23membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.31579940
24auditory behavior (GO:0031223)4.28841787
25neurotransmitter secretion (GO:0007269)4.24806777
26positive regulation of synaptic transmission, GABAergic (GO:0032230)4.21840996
27exploration behavior (GO:0035640)4.13955322
28positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.13161925
29regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.13021952
30positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.09957804
31neuron-neuron synaptic transmission (GO:0007270)4.08945014
32striatum development (GO:0021756)4.08808479
33neuron cell-cell adhesion (GO:0007158)4.06298166
34regulation of synaptic vesicle transport (GO:1902803)4.06239335
35adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.04143062
36synaptic transmission, glutamatergic (GO:0035249)4.01801816
37G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.98950377
38positive regulation of neurotransmitter transport (GO:0051590)3.98180533
39long-term memory (GO:0007616)3.95167828
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.94964174
41dendritic spine morphogenesis (GO:0060997)3.93564305
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.92004417
43regulation of dendritic spine morphogenesis (GO:0061001)3.89145133
44adenosine receptor signaling pathway (GO:0001973)3.87856396
45cerebellar granule cell differentiation (GO:0021707)3.86625273
46neuronal action potential propagation (GO:0019227)3.86160160
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.84280459
48response to amphetamine (GO:0001975)3.84000394
49positive regulation of membrane potential (GO:0045838)3.83897260
50dopamine receptor signaling pathway (GO:0007212)3.81212381
51cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.80738553
52L-amino acid import (GO:0043092)3.80243359
53behavioral response to cocaine (GO:0048148)3.79533167
54regulation of glutamate secretion (GO:0014048)3.79485358
55positive regulation of neurotransmitter secretion (GO:0001956)3.79323708
56layer formation in cerebral cortex (GO:0021819)3.78818449
57presynaptic membrane organization (GO:0097090)3.78274646
58negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.77867401
59response to auditory stimulus (GO:0010996)3.77075494
60positive regulation of dendritic spine morphogenesis (GO:0061003)3.75340934
61positive regulation of dendritic spine development (GO:0060999)3.74575873
62response to histamine (GO:0034776)3.73862426
63regulation of synaptic plasticity (GO:0048167)3.72626440
64establishment of mitochondrion localization (GO:0051654)3.72117880
65glutamate receptor signaling pathway (GO:0007215)3.71249597
66cerebellar Purkinje cell differentiation (GO:0021702)3.71017042
67gamma-aminobutyric acid transport (GO:0015812)3.70485420
68regulation of synaptic transmission, glutamatergic (GO:0051966)3.69448703
69regulation of postsynaptic membrane potential (GO:0060078)3.67823807
70long-term synaptic potentiation (GO:0060291)3.65576112
71axonal fasciculation (GO:0007413)3.65188085
72pyrimidine nucleobase catabolic process (GO:0006208)3.64370004
73synaptic vesicle endocytosis (GO:0048488)3.63422745
74presynaptic membrane assembly (GO:0097105)3.61693382
75cell migration in hindbrain (GO:0021535)3.61578076
76neuromuscular process controlling balance (GO:0050885)3.59758998
77transmission of nerve impulse (GO:0019226)3.54131540
78regulation of synapse maturation (GO:0090128)3.53895368
79activation of protein kinase A activity (GO:0034199)3.51930335
80potassium ion homeostasis (GO:0055075)3.49017532
81neuromuscular synaptic transmission (GO:0007274)3.48377191
82amino acid import (GO:0043090)3.47480678
83gamma-aminobutyric acid signaling pathway (GO:0007214)3.47299222
84regulation of female receptivity (GO:0045924)3.44828755
85cell communication by electrical coupling (GO:0010644)3.42594720
86neuronal ion channel clustering (GO:0045161)3.41864897
87regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.41804681
88regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.41804681
89axon ensheathment in central nervous system (GO:0032291)3.41532011
90central nervous system myelination (GO:0022010)3.41532011
91membrane hyperpolarization (GO:0060081)3.34211511
92dendritic spine organization (GO:0097061)3.33102861
93behavioral defense response (GO:0002209)3.30662620
94behavioral fear response (GO:0001662)3.30662620
95mechanosensory behavior (GO:0007638)3.30362644
96negative regulation of dendrite morphogenesis (GO:0050774)3.29508402
97visual learning (GO:0008542)3.29209149
98positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.28944127
99positive regulation of synapse maturation (GO:0090129)3.27588265
100neurotransmitter transport (GO:0006836)3.25467566
101cAMP catabolic process (GO:0006198)3.23374669
102membrane depolarization (GO:0051899)3.21989849
103negative regulation of synaptic transmission, GABAergic (GO:0032229)3.20606271
104regulation of neurotransmitter levels (GO:0001505)3.19639922
105membrane depolarization during action potential (GO:0086010)3.19415815
106regulation of synaptic transmission, GABAergic (GO:0032228)3.18695009
107positive regulation of synaptic transmission (GO:0050806)3.18684799
108regulation of dendritic spine development (GO:0060998)3.17728882
109proline transport (GO:0015824)3.15322181
110learning (GO:0007612)3.14622475
111synaptic transmission (GO:0007268)3.14024944
112potassium ion import (GO:0010107)3.13489292
113negative regulation of cytosolic calcium ion concentration (GO:0051481)3.12781516
114neuron recognition (GO:0008038)3.12461399
115regulation of neurotransmitter transport (GO:0051588)3.12043287
116substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.11801303
117substrate-independent telencephalic tangential migration (GO:0021826)3.11801303
118magnesium ion transport (GO:0015693)3.11783481
119establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.11766262
120mitochondrion transport along microtubule (GO:0047497)3.11766262
121adult walking behavior (GO:0007628)3.11683473
122negative regulation of dendrite development (GO:2000171)3.11069614
123regulation of neurotransmitter secretion (GO:0046928)3.10964870
124nucleobase catabolic process (GO:0046113)3.10788779
125regulation of neurotransmitter uptake (GO:0051580)3.09806836
126regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.08419893
127regulation of ARF protein signal transduction (GO:0032012)3.08127124
128visual behavior (GO:0007632)3.07980377
129regulation of synaptic transmission (GO:0050804)3.05737680
130establishment of synaptic vesicle localization (GO:0097480)3.04330934
131synaptic vesicle transport (GO:0048489)3.04330934
132female mating behavior (GO:0060180)3.03152260
133regulation of Rap GTPase activity (GO:0032317)3.02788938
134postsynaptic membrane organization (GO:0001941)3.02500221
135regulation of voltage-gated calcium channel activity (GO:1901385)3.01222494
136regulation of vesicle fusion (GO:0031338)2.96986926
137fear response (GO:0042596)2.96473202

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.77483321
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.51366792
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06604769
4GBX2_23144817_ChIP-Seq_PC3_Human3.04945603
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01274111
6DROSHA_22980978_ChIP-Seq_HELA_Human2.90940400
7IKZF1_21737484_ChIP-ChIP_HCT116_Human2.90646947
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89491661
9REST_21632747_ChIP-Seq_MESCs_Mouse2.75402022
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.74663426
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63677651
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63677651
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56359488
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54931914
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52642783
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49870219
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43344705
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.37093428
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.33653367
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33592173
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.33255461
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26697769
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.24159917
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.14062690
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.06714258
26AR_21572438_ChIP-Seq_LNCaP_Human1.99554505
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95110990
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90271992
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.86843959
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72350107
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66722530
32DNAJC2_21179169_ChIP-ChIP_NT2_Human1.65020536
33RNF2_27304074_Chip-Seq_NSC_Mouse1.61628191
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.55073024
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41898991
36* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40472489
37TAF15_26573619_Chip-Seq_HEK293_Human1.38178949
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37646005
39KDM2B_26808549_Chip-Seq_K562_Human1.37320945
40RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34371647
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33772495
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32313173
43GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32271298
44SMAD4_21799915_ChIP-Seq_A2780_Human1.31893147
45GATA1_26923725_Chip-Seq_HPCs_Mouse1.31792528
46* RING1B_27294783_Chip-Seq_ESCs_Mouse1.31147006
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30727643
48WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30488935
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30440372
50* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29652542
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29479347
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.25878109
53OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.25468116
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24852236
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24848723
56* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23198689
57P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18416190
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.16870065
59AR_19668381_ChIP-Seq_PC3_Human1.16616015
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14826012
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13440313
62AHR_22903824_ChIP-Seq_MCF-7_Human1.12916141
63RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10659128
64* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10229527
65* SMAD3_21741376_ChIP-Seq_EPCs_Human1.09534833
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08957570
67* CTCF_27219007_Chip-Seq_Bcells_Human1.07980145
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05482170
69* RING1B_27294783_Chip-Seq_NPCs_Mouse1.04565174
70* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03290309
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01193880
72* STAT3_23295773_ChIP-Seq_U87_Human1.00836444
73ZNF274_21170338_ChIP-Seq_K562_Hela1.00079440
74P300_19829295_ChIP-Seq_ESCs_Human0.99916337
75ARNT_22903824_ChIP-Seq_MCF-7_Human0.99875257
76AR_25329375_ChIP-Seq_VCAP_Human0.99715799
77SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99272305
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99269432
79FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98986292
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97535659
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96448740
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96448740
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96403630
84RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96367798
85* TCF4_23295773_ChIP-Seq_U87_Human0.96365748
86RXR_22108803_ChIP-Seq_LS180_Human0.96350444
87PRDM14_20953172_ChIP-Seq_ESCs_Human0.95970355
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94418275
89DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94328153
90KDM2B_26808549_Chip-Seq_DND41_Human0.93352118
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92782392
92TP53_20018659_ChIP-ChIP_R1E_Mouse0.92608160
93KDM2B_26808549_Chip-Seq_JURKAT_Human0.92258211
94IGF1R_20145208_ChIP-Seq_DFB_Human0.91850250
95YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90115891
96TP53_16413492_ChIP-PET_HCT116_Human0.88174139
97LXR_22292898_ChIP-Seq_THP-1_Human0.87987810
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87448667
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.86613756
100LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85856403
101TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.85691159
102SMAD3_21741376_ChIP-Seq_HESCs_Human0.85649811
103TET1_21490601_ChIP-Seq_MESCs_Mouse0.85610909
104CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85024145
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84465981
106OCT4_19829295_ChIP-Seq_ESCs_Human0.84404505
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84036552
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.84003628
109ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83468087
110CBX2_27304074_Chip-Seq_ESCs_Mouse0.82720294
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82343766
112KLF4_19829295_ChIP-Seq_ESCs_Human0.81181112
113NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80532158
114ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.79639985
115RUNX2_22187159_ChIP-Seq_PCA_Human0.79243985
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78927881
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78647207
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78493835
119DPY_21335234_ChIP-Seq_ESCs_Mouse0.77295102
120TOP2B_26459242_ChIP-Seq_MCF-7_Human0.77056588
121JUN_21703547_ChIP-Seq_K562_Human0.75975408
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75378314
123EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.74068999
124SOX9_26525672_Chip-Seq_HEART_Mouse0.74030765
125TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.73793509

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.73567295
2MP0002822_catalepsy6.29338068
3MP0003880_abnormal_central_pattern4.75025483
4MP0003635_abnormal_synaptic_transmissio4.23504415
5MP0009745_abnormal_behavioral_response3.69885211
6MP0002063_abnormal_learning/memory/cond3.69283342
7MP0004270_analgesia3.30576240
8MP0002064_seizures3.18263024
9MP0002572_abnormal_emotion/affect_behav3.11204203
10MP0005423_abnormal_somatic_nervous2.84018118
11MP0009046_muscle_twitch2.79885341
12MP0001968_abnormal_touch/_nociception2.77972256
13MP0001486_abnormal_startle_reflex2.65383647
14MP0002272_abnormal_nervous_system2.42583360
15MP0002909_abnormal_adrenal_gland2.31401564
16MP0001529_abnormal_vocalization2.22159220
17MP0002734_abnormal_mechanical_nocicepti2.11548842
18MP0001501_abnormal_sleep_pattern2.07342703
19MP0002736_abnormal_nociception_after2.05622829
20MP0002557_abnormal_social/conspecific_i1.99854489
21MP0005646_abnormal_pituitary_gland1.92661625
22MP0001440_abnormal_grooming_behavior1.92023129
23MP0002733_abnormal_thermal_nociception1.89243873
24MP0001970_abnormal_pain_threshold1.84041319
25MP0004924_abnormal_behavior1.83221545
26MP0005386_behavior/neurological_phenoty1.83221545
27MP0008569_lethality_at_weaning1.81972004
28MP0003123_paternal_imprinting1.78693969
29MP0004811_abnormal_neuron_physiology1.74228802
30MP0009780_abnormal_chondrocyte_physiolo1.71393443
31MP0002735_abnormal_chemical_nociception1.68827643
32MP0002067_abnormal_sensory_capabilities1.67243155
33MP0001984_abnormal_olfaction1.61959536
34MP0003879_abnormal_hair_cell1.59021424
35MP0003329_amyloid_beta_deposits1.57226791
36MP0002837_dystrophic_cardiac_calcinosis1.53044347
37MP0002184_abnormal_innervation1.48665461
38MP0003303_peritoneal_inflammation1.47020119
39MP0008961_abnormal_basal_metabolism1.45162040
40MP0000778_abnormal_nervous_system1.43530136
41MP0003121_genomic_imprinting1.42026066
42MP0001905_abnormal_dopamine_level1.37421718
43MP0000955_abnormal_spinal_cord1.35567124
44MP0002066_abnormal_motor_capabilities/c1.35480172
45MP0008872_abnormal_physiological_respon1.30501324
46MP0005409_darkened_coat_color1.29471954
47MP0003787_abnormal_imprinting1.28130423
48MP0003633_abnormal_nervous_system1.27738619
49MP0004885_abnormal_endolymph1.23866705
50MP0005645_abnormal_hypothalamus_physiol1.22762896
51MP0008874_decreased_physiological_sensi1.22738905
52MP0002882_abnormal_neuron_morphology1.19135314
53MP0008877_abnormal_DNA_methylation1.18564784
54MP0004858_abnormal_nervous_system1.16759759
55MP0002638_abnormal_pupillary_reflex1.12579781
56MP0003122_maternal_imprinting1.11652212
57MP0006276_abnormal_autonomic_nervous1.11078063
58MP0001188_hyperpigmentation1.07938478
59MP0003075_altered_response_to1.05481089
60MP0001502_abnormal_circadian_rhythm1.05372658
61MP0004142_abnormal_muscle_tone1.02496979
62MP0002069_abnormal_eating/drinking_beha1.01350922
63MP0005551_abnormal_eye_electrophysiolog1.01276020
64MP0004742_abnormal_vestibular_system1.01180074
65MP0001177_atelectasis0.99811008
66MP0003631_nervous_system_phenotype0.98600993
67MP0002152_abnormal_brain_morphology0.96647358
68MP0005535_abnormal_body_temperature0.92098192
69MP0002653_abnormal_ependyma_morphology0.91909490
70MP0001986_abnormal_taste_sensitivity0.89786665
71MP0004085_abnormal_heartbeat0.89396884
72MP0003690_abnormal_glial_cell0.87205832
73MP0000751_myopathy0.86514235
74MP0000013_abnormal_adipose_tissue0.86173837
75MP0004147_increased_porphyrin_level0.84056273
76MP0000569_abnormal_digit_pigmentation0.82502034
77MP0005499_abnormal_olfactory_system0.80729249
78MP0005394_taste/olfaction_phenotype0.80729249
79MP0001348_abnormal_lacrimal_gland0.78088097
80MP0001485_abnormal_pinna_reflex0.77545304
81MP0000631_abnormal_neuroendocrine_gland0.74562708
82MP0003861_abnormal_nervous_system0.73739935
83MP0000920_abnormal_myelination0.73018255
84MP0000604_amyloidosis0.72067302
85MP0010234_abnormal_vibrissa_follicle0.71753984
86MP0005167_abnormal_blood-brain_barrier0.71166878
87MP0004510_myositis0.70301599
88MP0001943_abnormal_respiration0.67574478
89MP0000026_abnormal_inner_ear0.67272698
90MP0003183_abnormal_peptide_metabolism0.66746360
91MP0002229_neurodegeneration0.66613623
92MP0003172_abnormal_lysosome_physiology0.65181471
93MP0001346_abnormal_lacrimal_gland0.64520119
94MP0003634_abnormal_glial_cell0.61706584
95MP0002090_abnormal_vision0.61582980
96MP0003938_abnormal_ear_development0.61224103
97MP0003283_abnormal_digestive_organ0.61166541
98MP0004130_abnormal_muscle_cell0.61111459
99MP0005166_decreased_susceptibility_to0.56790633
100MP0001299_abnormal_eye_distance/0.56182166
101MP0001963_abnormal_hearing_physiology0.55151866
102MP0004133_heterotaxia0.54967483
103MP0005187_abnormal_penis_morphology0.51126954
104MP0003137_abnormal_impulse_conducting0.50897814
105MP0003632_abnormal_nervous_system0.49739673
106MP0010769_abnormal_survival0.48007719
107MP0003956_abnormal_body_size0.46384489
108MP0002752_abnormal_somatic_nervous0.46284766
109MP0005623_abnormal_meninges_morphology0.45121284
110MP0002082_postnatal_lethality0.44679406
111MP0010770_preweaning_lethality0.44679406
112MP0010768_mortality/aging0.44447421
113MP0001664_abnormal_digestion0.44267713
114MP0005387_immune_system_phenotype0.43053705
115MP0001790_abnormal_immune_system0.43053705
116MP0005448_abnormal_energy_balance0.41546516
117MP0010386_abnormal_urinary_bladder0.41390056
118MP0005310_abnormal_salivary_gland0.39778232

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.14603839
2Focal motor seizures (HP:0011153)7.66013314
3Focal seizures (HP:0007359)5.79544235
4Visual hallucinations (HP:0002367)4.66195313
5Epileptic encephalopathy (HP:0200134)4.27810781
6Poor eye contact (HP:0000817)3.88209071
7Febrile seizures (HP:0002373)3.86623389
8Atonic seizures (HP:0010819)3.75355040
9Annular pancreas (HP:0001734)3.71661470
10Torticollis (HP:0000473)3.69301608
11Ankle clonus (HP:0011448)3.67663291
12Broad-based gait (HP:0002136)3.65189051
13Abnormal social behavior (HP:0012433)3.59334817
14Impaired social interactions (HP:0000735)3.59334817
15Absence seizures (HP:0002121)3.59211883
16Impaired vibration sensation in the lower limbs (HP:0002166)3.54248273
17Abnormal eating behavior (HP:0100738)3.52987493
18Urinary bladder sphincter dysfunction (HP:0002839)3.52382095
19Generalized tonic-clonic seizures (HP:0002069)3.49216208
20Depression (HP:0000716)3.48765594
21Hyperventilation (HP:0002883)3.35211470
22Anxiety (HP:0000739)3.35184415
23Dialeptic seizures (HP:0011146)3.33670435
24Action tremor (HP:0002345)3.33283789
25Progressive cerebellar ataxia (HP:0002073)3.31785994
26Focal dystonia (HP:0004373)3.26296863
27Supranuclear gaze palsy (HP:0000605)3.26235036
28Urinary urgency (HP:0000012)3.23407825
29Dysdiadochokinesis (HP:0002075)3.21630406
30Truncal ataxia (HP:0002078)3.19869307
31Resting tremor (HP:0002322)3.17064361
32Craniofacial dystonia (HP:0012179)3.10997176
33Stereotypic behavior (HP:0000733)3.05775422
34Gaze-evoked nystagmus (HP:0000640)3.03081383
35Dysmetric saccades (HP:0000641)3.00431019
36Dysmetria (HP:0001310)3.00232139
37Postural instability (HP:0002172)2.96667097
38Papilledema (HP:0001085)2.92799032
39Akinesia (HP:0002304)2.90761748
40Lower limb amyotrophy (HP:0007210)2.87326214
41Spastic gait (HP:0002064)2.86811139
42Cerebral hypomyelination (HP:0006808)2.85238575
43Progressive inability to walk (HP:0002505)2.72076395
44Amblyopia (HP:0000646)2.67715258
45Limb dystonia (HP:0002451)2.67221431
46Impaired smooth pursuit (HP:0007772)2.65441793
47Tetraplegia (HP:0002445)2.62436056
48Mutism (HP:0002300)2.62300075
49Abnormality of binocular vision (HP:0011514)2.59999602
50Diplopia (HP:0000651)2.59999602
51Pointed chin (HP:0000307)2.57827034
52Abnormality of the lower motor neuron (HP:0002366)2.57279965
53Delusions (HP:0000746)2.53920246
54Agammaglobulinemia (HP:0004432)2.52765944
55Scanning speech (HP:0002168)2.52705308
56Peripheral hypomyelination (HP:0007182)2.51369446
57Hemiplegia (HP:0002301)2.51257105
58Bradykinesia (HP:0002067)2.44599943
59Excessive salivation (HP:0003781)2.43629627
60Drooling (HP:0002307)2.43629627
61Ankyloglossia (HP:0010296)2.38274101
62Apathy (HP:0000741)2.36003175
63Polyphagia (HP:0002591)2.35944645
64Impaired vibratory sensation (HP:0002495)2.30821624
65Morphological abnormality of the pyramidal tract (HP:0002062)2.29330130
66Failure to thrive in infancy (HP:0001531)2.24392342
67Degeneration of the lateral corticospinal tracts (HP:0002314)2.23567321
68Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.23567321
69Hemiparesis (HP:0001269)2.22990888
70Abnormality of ocular smooth pursuit (HP:0000617)2.21353929
71Epileptiform EEG discharges (HP:0011182)2.20231796
72Lower limb muscle weakness (HP:0007340)2.19869870
73Spastic tetraplegia (HP:0002510)2.19030317
74Genetic anticipation (HP:0003743)2.18971257
75Intention tremor (HP:0002080)2.17489425
76Gait imbalance (HP:0002141)2.16910703
77Diminished motivation (HP:0000745)2.16435293
78Absent speech (HP:0001344)2.16227322
79Status epilepticus (HP:0002133)2.16226561
80Amyotrophic lateral sclerosis (HP:0007354)2.14766830
81Abnormal EKG (HP:0003115)2.12322770
82Split foot (HP:0001839)2.10869708
83Papilloma (HP:0012740)2.10764362
84Verrucae (HP:0200043)2.10764362
85CNS hypomyelination (HP:0003429)2.09573169
86Cerebral inclusion bodies (HP:0100314)2.09213879
87Megalencephaly (HP:0001355)2.09161181
88EEG with generalized epileptiform discharges (HP:0011198)2.08461918
89Neurofibrillary tangles (HP:0002185)2.08398728
90Ventricular fibrillation (HP:0001663)2.07641668
91Clonus (HP:0002169)2.05964282
92Incomplete penetrance (HP:0003829)2.03850100
93Hypsarrhythmia (HP:0002521)2.03032505
94Spinal canal stenosis (HP:0003416)2.02782086
95Distal lower limb amyotrophy (HP:0008944)2.02643365
96Insomnia (HP:0100785)2.01417670
97Obstructive sleep apnea (HP:0002870)2.00831077
98Abnormality of the corticospinal tract (HP:0002492)2.00189844
99Neoplasm of the heart (HP:0100544)2.00095820
100Generalized hypotonia (HP:0001290)1.99446035
101Abnormality of saccadic eye movements (HP:0000570)1.98223475
102Neuronal loss in central nervous system (HP:0002529)1.96956655
103Spastic tetraparesis (HP:0001285)1.96730880
104Deep palmar crease (HP:0006191)1.95889764
105Fetal akinesia sequence (HP:0001989)1.94083612
106Agitation (HP:0000713)1.93380366
107Inability to walk (HP:0002540)1.92613274
108Sleep apnea (HP:0010535)1.92598797
109Termporal pattern (HP:0011008)1.92496829
110Insidious onset (HP:0003587)1.92496829
111Hypoplasia of the corpus callosum (HP:0002079)1.91833121
112Specific learning disability (HP:0001328)1.90455383
113Lower limb asymmetry (HP:0100559)1.90233952
114Prolonged QT interval (HP:0001657)1.89788309
115Abnormality of oral frenula (HP:0000190)1.88671759
116Psychosis (HP:0000709)1.85530726
117Poor suck (HP:0002033)1.85048883
118Rapidly progressive (HP:0003678)1.84811988
119Rigidity (HP:0002063)1.81985439
120Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78318480
121Iris hypopigmentation (HP:0007730)1.78268730
122Hypoventilation (HP:0002791)1.77819356
123Abnormality of the labia minora (HP:0012880)1.76261277
124Paraplegia (HP:0010550)1.73027272
125Choreoathetosis (HP:0001266)1.71464241
126Hypoplasia of the brainstem (HP:0002365)1.71204395
127Aplasia/Hypoplasia of the brainstem (HP:0007362)1.71204395

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.94889196
2MAP3K94.15989624
3NTRK33.86744325
4DAPK22.74056416
5RIPK42.68002147
6MARK12.48614633
7MAP3K42.22450381
8MINK12.20466817
9KSR22.17807827
10SIK22.07412569
11CAMKK11.94096229
12NTRK21.90786230
13MAP4K11.87579200
14PAK61.85967355
15FES1.84508830
16PRKD31.79829606
17MAP3K131.78929285
18TAOK11.76905116
19MAP2K71.75049609
20KSR11.73296315
21DAPK11.64104522
22MAP3K121.63600237
23CDK51.63214833
24CDK191.59952416
25CASK1.54805497
26PRPF4B1.48717388
27ARAF1.48550031
28NTRK11.45673227
29SIK31.45250269
30PAK31.41407442
31LATS21.34218303
32TNIK1.24882990
33MAP2K41.20979364
34PRKCH1.19859194
35DYRK21.18025400
36STK111.08555674
37MARK21.04045569
38TNK21.01865119
39SGK2230.98775320
40SGK4940.98775320
41UHMK10.95276068
42SGK30.94897121
43ALK0.94392430
44SGK20.92824178
45RAF10.92512592
46STK380.92356814
47MAP3K20.91719645
48MAPK130.91032272
49GRK50.88018762
50TYRO30.87903412
51PRKCG0.87632682
52CDK180.87287353
53CAMKK20.86053376
54PDK10.82945806
55PKN10.82479862
56CDK150.82452812
57PLK20.81785373
58BMPR20.81270944
59CAMK10.76921004
60LIMK10.76619193
61PRKD20.76195431
62CAMK2A0.75799641
63SYK0.74736694
64BCR0.74687573
65CDK140.74028100
66CDK11A0.72742761
67SGK10.70392605
68PDPK10.69934224
69FYN0.65839651
70RET0.64886428
71MAP3K10.64841896
72PTK2B0.64151283
73NEK60.62977183
74CAMK2B0.62343232
75CSNK1G20.61992320
76DAPK30.61981103
77CAMK2G0.61951577
78GRK60.60846238
79MAP2K10.59132858
80TRIB30.58884027
81MAP3K110.58652195
82BRSK10.56922086
83PHKG10.55127190
84PHKG20.55127190
85CSNK1G30.54227288
86LMTK20.53577988
87PRKCZ0.52724959
88CSNK1A1L0.52574717
89PINK10.52117094
90FGR0.48568443
91CAMK40.47884585
92RPS6KA30.46950687
93RIPK10.45942520
94HCK0.42897192
95DYRK1B0.42571440
96RPS6KA20.42118208
97PRKCQ0.41943833
98CDC42BPA0.41770729
99MAPK120.37888317
100CAMK2D0.37887858
101MAPK100.37430340
102CSNK1E0.37305998
103TESK10.36614404
104PRKCB0.36409760
105MAP3K70.36322692
106CLK10.36283646
107OXSR10.36050917
108MAPK70.36036267
109DYRK1A0.35583433
110PRKCA0.35137946
111CAMK1G0.34602284
112JAK10.34535916
113FGFR20.33678867
114* PRKACA0.33311362
115DMPK0.33158860
116CSNK1A10.32719274
117BRAF0.32678501
118CSNK1D0.32594104
119PRKCE0.32498913
120PNCK0.32400317
121PRKG10.32002280
122CCNB10.31923406
123ERBB20.31624050
124BMX0.31454422
125CSNK1G10.30761528
126WNK30.30367967
127TRIM280.29633251
128MAPK80.28398210

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.15249966
2Olfactory transduction_Homo sapiens_hsa047403.14595129
3Synaptic vesicle cycle_Homo sapiens_hsa047213.00537250
4Morphine addiction_Homo sapiens_hsa050322.73845637
5Circadian entrainment_Homo sapiens_hsa047132.68503066
6GABAergic synapse_Homo sapiens_hsa047272.62616241
7Long-term potentiation_Homo sapiens_hsa047202.54649008
8Amphetamine addiction_Homo sapiens_hsa050312.50042358
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.41053607
10Glutamatergic synapse_Homo sapiens_hsa047242.39799364
11Dopaminergic synapse_Homo sapiens_hsa047282.26406320
12Cocaine addiction_Homo sapiens_hsa050302.24949781
13Cholinergic synapse_Homo sapiens_hsa047252.00592103
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.99767936
15Salivary secretion_Homo sapiens_hsa049701.97475224
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.89818757
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84870852
18Gastric acid secretion_Homo sapiens_hsa049711.77251632
19Insulin secretion_Homo sapiens_hsa049111.74827482
20Renin secretion_Homo sapiens_hsa049241.74708168
21Oxytocin signaling pathway_Homo sapiens_hsa049211.68616691
22Calcium signaling pathway_Homo sapiens_hsa040201.64211919
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57685715
24Long-term depression_Homo sapiens_hsa047301.54211055
25Serotonergic synapse_Homo sapiens_hsa047261.50333274
26Gap junction_Homo sapiens_hsa045401.45818387
27Taste transduction_Homo sapiens_hsa047421.43699256
28GnRH signaling pathway_Homo sapiens_hsa049121.36537982
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27109908
30cAMP signaling pathway_Homo sapiens_hsa040241.26850669
31Nitrogen metabolism_Homo sapiens_hsa009101.18999386
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18842740
33Glioma_Homo sapiens_hsa052141.18201389
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18058942
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12596351
36Collecting duct acid secretion_Homo sapiens_hsa049661.11313322
37B cell receptor signaling pathway_Homo sapiens_hsa046621.09597081
38Axon guidance_Homo sapiens_hsa043601.04644913
39Type II diabetes mellitus_Homo sapiens_hsa049301.02867830
40Estrogen signaling pathway_Homo sapiens_hsa049151.02448482
41ErbB signaling pathway_Homo sapiens_hsa040121.02336576
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00098437
43cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97468871
44Vitamin B6 metabolism_Homo sapiens_hsa007500.96599943
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95810110
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94936459
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.93182136
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92250631
49Non-small cell lung cancer_Homo sapiens_hsa052230.88067540
50Dorso-ventral axis formation_Homo sapiens_hsa043200.85672981
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.83422045
52Melanogenesis_Homo sapiens_hsa049160.83417034
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.82389214
54* MAPK signaling pathway_Homo sapiens_hsa040100.81119288
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80736706
56Chemokine signaling pathway_Homo sapiens_hsa040620.78646236
57African trypanosomiasis_Homo sapiens_hsa051430.76898349
58VEGF signaling pathway_Homo sapiens_hsa043700.76064780
59Vibrio cholerae infection_Homo sapiens_hsa051100.75402753
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73171285
61Rap1 signaling pathway_Homo sapiens_hsa040150.69608287
62Dilated cardiomyopathy_Homo sapiens_hsa054140.68792518
63Alcoholism_Homo sapiens_hsa050340.67445200
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66383260
65Pancreatic secretion_Homo sapiens_hsa049720.66281945
66Choline metabolism in cancer_Homo sapiens_hsa052310.66078681
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64972573
68Oocyte meiosis_Homo sapiens_hsa041140.63605115
69Cardiac muscle contraction_Homo sapiens_hsa042600.63108259
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62615499
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61085047
72Thyroid hormone synthesis_Homo sapiens_hsa049180.60394604
73Alzheimers disease_Homo sapiens_hsa050100.59938318
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57372654
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56464979
76Endocytosis_Homo sapiens_hsa041440.55394475
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54639989
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53981366
79Phototransduction_Homo sapiens_hsa047440.53920605
80Ras signaling pathway_Homo sapiens_hsa040140.52494735
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.52162685
82Endometrial cancer_Homo sapiens_hsa052130.51384669
83Inositol phosphate metabolism_Homo sapiens_hsa005620.50170839
84Type I diabetes mellitus_Homo sapiens_hsa049400.49787951
85Glucagon signaling pathway_Homo sapiens_hsa049220.49475475
86Renal cell carcinoma_Homo sapiens_hsa052110.49026907
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48873685
88mTOR signaling pathway_Homo sapiens_hsa041500.48752105
89Platelet activation_Homo sapiens_hsa046110.47298902
90Regulation of autophagy_Homo sapiens_hsa041400.46799120
91T cell receptor signaling pathway_Homo sapiens_hsa046600.46185630
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45796473
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44782448
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44205961
95Wnt signaling pathway_Homo sapiens_hsa043100.41404417
96Insulin signaling pathway_Homo sapiens_hsa049100.40941176
97Circadian rhythm_Homo sapiens_hsa047100.40193089
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38611983
99Ovarian steroidogenesis_Homo sapiens_hsa049130.38611396
100Bile secretion_Homo sapiens_hsa049760.37044207
101Fatty acid biosynthesis_Homo sapiens_hsa000610.36401152
102Oxidative phosphorylation_Homo sapiens_hsa001900.35845647
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34709609
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34098982
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33752080
106Hippo signaling pathway_Homo sapiens_hsa043900.33452519
107Arginine and proline metabolism_Homo sapiens_hsa003300.33407163
108Parkinsons disease_Homo sapiens_hsa050120.32561738
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32232976
110Prion diseases_Homo sapiens_hsa050200.32109046
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32105685
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30506888
113Osteoclast differentiation_Homo sapiens_hsa043800.29602628
114AMPK signaling pathway_Homo sapiens_hsa041520.28252190
115Arginine biosynthesis_Homo sapiens_hsa002200.26813991
116Tight junction_Homo sapiens_hsa045300.26663062
117beta-Alanine metabolism_Homo sapiens_hsa004100.19248822
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.18617379
119Ether lipid metabolism_Homo sapiens_hsa005650.18360644

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »