PTPN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.02588511
2L-phenylalanine catabolic process (GO:0006559)5.02588511
3L-phenylalanine metabolic process (GO:0006558)4.92990618
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.92990618
5kynurenine metabolic process (GO:0070189)4.64047761
6lysine metabolic process (GO:0006553)4.53838785
7lysine catabolic process (GO:0006554)4.53838785
8aromatic amino acid family catabolic process (GO:0009074)4.52940052
9cysteine metabolic process (GO:0006534)4.33983519
10indole-containing compound catabolic process (GO:0042436)4.19796313
11indolalkylamine catabolic process (GO:0046218)4.19796313
12tryptophan catabolic process (GO:0006569)4.19796313
13dicarboxylic acid biosynthetic process (GO:0043650)4.19358210
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.16380295
15urea metabolic process (GO:0019627)4.08679070
16urea cycle (GO:0000050)4.08679070
17bile acid biosynthetic process (GO:0006699)4.06629225
18sulfur amino acid catabolic process (GO:0000098)4.01917350
19glyoxylate metabolic process (GO:0046487)3.99586874
20homocysteine metabolic process (GO:0050667)3.92540610
21alpha-linolenic acid metabolic process (GO:0036109)3.87766646
22high-density lipoprotein particle remodeling (GO:0034375)3.87189458
23tryptophan metabolic process (GO:0006568)3.86954439
24regulation of protein activation cascade (GO:2000257)3.84741883
25glutamate metabolic process (GO:0006536)3.79234019
262-oxoglutarate metabolic process (GO:0006103)3.77456166
27nitrogen cycle metabolic process (GO:0071941)3.71187462
28amino-acid betaine metabolic process (GO:0006577)3.70272755
29serine family amino acid catabolic process (GO:0009071)3.69922937
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.66717300
31aspartate family amino acid catabolic process (GO:0009068)3.65815662
32regulation of cholesterol homeostasis (GO:2000188)3.65070967
33complement activation, alternative pathway (GO:0006957)3.64649431
34regulation of complement activation (GO:0030449)3.63023879
35cellular ketone body metabolic process (GO:0046950)3.54225810
36regulation of triglyceride catabolic process (GO:0010896)3.53348010
37cellular modified amino acid catabolic process (GO:0042219)3.52229314
38negative regulation of fibrinolysis (GO:0051918)3.50977150
39drug catabolic process (GO:0042737)3.50257966
40bile acid metabolic process (GO:0008206)3.49120413
41peptidyl-glutamic acid carboxylation (GO:0017187)3.48628298
42protein carboxylation (GO:0018214)3.48628298
43alpha-amino acid catabolic process (GO:1901606)3.47152256
44carnitine transmembrane transport (GO:1902603)3.44558950
45reverse cholesterol transport (GO:0043691)3.40868392
46bundle of His cell to Purkinje myocyte communication (GO:0086069)3.40423435
47muscle filament sliding (GO:0030049)3.40316156
48actin-myosin filament sliding (GO:0033275)3.40316156
49epoxygenase P450 pathway (GO:0019373)3.37410134
50fatty acid transmembrane transport (GO:1902001)3.36726204
51carnitine shuttle (GO:0006853)3.33936810
52acetyl-CoA metabolic process (GO:0006084)3.33454314
53regulation of fibrinolysis (GO:0051917)3.33217439
54triglyceride homeostasis (GO:0070328)3.32429542
55acylglycerol homeostasis (GO:0055090)3.32429542
56cellular glucuronidation (GO:0052695)3.32146883
57regulation of bile acid biosynthetic process (GO:0070857)3.32088550
58quaternary ammonium group transport (GO:0015697)3.32058562
59ethanol oxidation (GO:0006069)3.30817310
60short-chain fatty acid metabolic process (GO:0046459)3.30480886
61cellular amino acid catabolic process (GO:0009063)3.29719416
62cilium or flagellum-dependent cell motility (GO:0001539)3.26725495
63negative regulation of cholesterol transport (GO:0032375)3.24617256
64negative regulation of sterol transport (GO:0032372)3.24617256
65regulation of glucokinase activity (GO:0033131)3.23948832
66regulation of hexokinase activity (GO:1903299)3.23948832
67aromatic amino acid family metabolic process (GO:0009072)3.21541194
68phospholipid efflux (GO:0033700)3.21537006
69protein-lipid complex remodeling (GO:0034368)3.19903479
70macromolecular complex remodeling (GO:0034367)3.19903479
71plasma lipoprotein particle remodeling (GO:0034369)3.19903479
72macroautophagy (GO:0016236)3.17447281
73exogenous drug catabolic process (GO:0042738)3.14570316
74phospholipid homeostasis (GO:0055091)3.13424941
75bile acid and bile salt transport (GO:0015721)3.13344080
76regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.10639782
77coenzyme catabolic process (GO:0009109)3.09571785
78actin-mediated cell contraction (GO:0070252)3.07018918
79benzene-containing compound metabolic process (GO:0042537)3.06445843
80regulation of cholesterol esterification (GO:0010872)3.05900406
81ketone body metabolic process (GO:1902224)3.05040186
82drug transmembrane transport (GO:0006855)3.02992235
83negative regulation of protein activation cascade (GO:2000258)3.02764805
84fatty acid beta-oxidation (GO:0006635)2.98029767
85flavonoid metabolic process (GO:0009812)2.97841875
86intestinal epithelial cell development (GO:0060576)2.97276100
87response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.96801118
88oxidative demethylation (GO:0070989)2.95667049
89positive regulation of glycolytic process (GO:0045821)2.95577820
90fatty acid oxidation (GO:0019395)2.94480952
91desmosome organization (GO:0002934)2.94137487
92carnitine metabolic process (GO:0009437)2.93798588
93positive regulation of lipid catabolic process (GO:0050996)2.93693488
94cholesterol efflux (GO:0033344)2.91439002
95myofibril assembly (GO:0030239)2.89959049
96organic acid catabolic process (GO:0016054)2.89384226
97carboxylic acid catabolic process (GO:0046395)2.89384226
98tyrosine metabolic process (GO:0006570)2.89130862
99lipid oxidation (GO:0034440)2.88329448
100monocarboxylic acid catabolic process (GO:0072329)2.88160164
101sarcomere organization (GO:0045214)2.88027809
102sarcoplasmic reticulum calcium ion transport (GO:0070296)2.87778673
103skeletal muscle adaptation (GO:0043501)2.87698634
104glucuronate metabolic process (GO:0019585)2.87656087
105uronic acid metabolic process (GO:0006063)2.87656087
106plasma membrane repair (GO:0001778)2.86307680
107fatty acid catabolic process (GO:0009062)2.85137886
108regulation of acrosome reaction (GO:0060046)2.84695113
109axonemal dynein complex assembly (GO:0070286)2.84534072
110ventricular cardiac muscle cell action potential (GO:0086005)2.82272422
111regulation of skeletal muscle contraction (GO:0014819)2.82028945
112serine family amino acid metabolic process (GO:0009069)2.81099533
113omega-hydroxylase P450 pathway (GO:0097267)2.80812174
114pyrimidine nucleoside catabolic process (GO:0046135)2.79998162
115negative regulation of lipase activity (GO:0060192)2.79563400
116skeletal muscle contraction (GO:0003009)2.79074161
117positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.77500712
118phenylpropanoid metabolic process (GO:0009698)2.76852490
119intestinal cholesterol absorption (GO:0030299)2.75744783
120plasma lipoprotein particle clearance (GO:0034381)2.74801269
121positive regulation of fatty acid beta-oxidation (GO:0032000)2.74002566
122indolalkylamine metabolic process (GO:0006586)2.72919817
123cell communication involved in cardiac conduction (GO:0086065)2.72567136
124amino-acid betaine transport (GO:0015838)2.71157278
125carnitine transport (GO:0015879)2.71157278
126drug metabolic process (GO:0017144)2.70366616
127glycine metabolic process (GO:0006544)2.69880638
128cilium movement (GO:0003341)2.66286229
129regulation of relaxation of muscle (GO:1901077)2.63386907
130establishment of skin barrier (GO:0061436)2.56103247
131positive regulation of fatty acid oxidation (GO:0046321)2.52506361
132response to muscle activity (GO:0014850)2.52171528
133ethanol metabolic process (GO:0006067)2.51935580
134actomyosin structure organization (GO:0031032)2.49398963
135regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.48487094
136regulation of cell communication by electrical coupling (GO:0010649)2.47728726
137multicellular organismal water homeostasis (GO:0050891)2.47170945
138auditory receptor cell stereocilium organization (GO:0060088)2.46056418
139striated muscle atrophy (GO:0014891)2.45903623
140biotin metabolic process (GO:0006768)2.44376442
141regulation of water loss via skin (GO:0033561)2.44259263
142vitamin transmembrane transport (GO:0035461)2.43319112
143glycogen catabolic process (GO:0005980)2.42897292
144axoneme assembly (GO:0035082)2.41914872
145striated muscle contraction (GO:0006941)2.39247591
146L-methionine biosynthetic process (GO:0071265)2.37247858
147amino acid salvage (GO:0043102)2.37247858
148L-methionine salvage (GO:0071267)2.37247858
149organic cation transport (GO:0015695)2.36314575
150thyroid hormone metabolic process (GO:0042403)2.34599897
151establishment of protein localization to Golgi (GO:0072600)2.30853039
152water homeostasis (GO:0030104)2.29868471
153negative regulation of cytosolic calcium ion concentration (GO:0051481)2.29824833
154piRNA metabolic process (GO:0034587)2.28004538
155actin filament-based movement (GO:0030048)2.27462908
156glucan catabolic process (GO:0009251)2.27118961
157cardiac muscle cell action potential (GO:0086001)2.25870499
158regulation of fatty acid oxidation (GO:0046320)2.25212713
159primary alcohol catabolic process (GO:0034310)2.23716772
160cardiac myofibril assembly (GO:0055003)2.23055665
161epithelial cilium movement (GO:0003351)2.22375587
162regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.21337612
163cardiac conduction (GO:0061337)2.20375185

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.64020595
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.71916120
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.12183097
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.92486918
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.29526832
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.13918826
7* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.06858959
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.89650568
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.33862386
10VDR_22108803_ChIP-Seq_LS180_Human2.33738582
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.27487591
12ZNF263_19887448_ChIP-Seq_K562_Human2.11930919
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98438478
14ER_23166858_ChIP-Seq_MCF-7_Human1.97444466
15ESR2_21235772_ChIP-Seq_MCF-7_Human1.94244369
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89434258
17POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85984077
18IGF1R_20145208_ChIP-Seq_DFB_Human1.80592100
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79765248
20* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.78234983
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.77469158
22ZNF274_21170338_ChIP-Seq_K562_Hela1.77381378
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73338001
24FOXM1_26456572_ChIP-Seq_MCF-7_Human1.69729320
25CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.68973511
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64457542
27FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.63522250
28TAF15_26573619_Chip-Seq_HEK293_Human1.61102458
29EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.60390132
30FOXA2_19822575_ChIP-Seq_HepG2_Human1.57780833
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57516376
32CDX2_22108803_ChIP-Seq_LS180_Human1.53528745
33* STAT3_23295773_ChIP-Seq_U87_Human1.53226704
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.53016049
35NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52570225
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50652775
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50135538
38EZH2_22144423_ChIP-Seq_EOC_Human1.49025961
39TCF4_23295773_ChIP-Seq_U87_Human1.48702860
40TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.45168803
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44801391
42AR_25329375_ChIP-Seq_VCAP_Human1.44703604
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42331777
44DROSHA_22980978_ChIP-Seq_HELA_Human1.42326687
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41552470
46* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.41524277
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37936350
48FUS_26573619_Chip-Seq_HEK293_Human1.37295189
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37284577
50CBP_20019798_ChIP-Seq_JUKART_Human1.37284577
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35405918
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.34743517
53* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34344499
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34270281
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33058475
56CLOCK_20551151_ChIP-Seq_293T_Human1.30338200
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29703195
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28472284
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.28191406
60FOXA1_25552417_ChIP-Seq_VCAP_Human1.27112392
61TCF4_22108803_ChIP-Seq_LS180_Human1.25285430
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24940086
63CJUN_26792858_Chip-Seq_BT549_Human1.24604000
64* TP63_23658742_ChIP-Seq_EP156T_Human1.22519464
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.21644324
66TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21277312
67RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21263769
68P300_19829295_ChIP-Seq_ESCs_Human1.21082651
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20803006
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20237174
71SMAD4_21741376_ChIP-Seq_EPCs_Human1.20079070
72* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18570744
73* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18485743
74MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17643968
75SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16756013
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.16629891
77SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16333794
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13131620
79AHR_22903824_ChIP-Seq_MCF-7_Human1.12365244
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10434273
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10190807
82GATA3_24758297_ChIP-Seq_MCF-7_Human1.10017840
83EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09805599
84RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09805599
85TCF4_18268006_ChIP-ChIP_LS174T_Human1.08599162
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08479392
87FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.08270681
88RARB_27405468_Chip-Seq_BRAIN_Mouse1.07940243
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07231380
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07109808
91GBX2_23144817_ChIP-Seq_PC3_Human1.06874192
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06318683
93ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05975906
94AR_21572438_ChIP-Seq_LNCaP_Human1.05672669
95BCAT_22108803_ChIP-Seq_LS180_Human1.05134387
96SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05040845
97RUNX2_22187159_ChIP-Seq_PCA_Human1.04164045
98HNF4A_19822575_ChIP-Seq_HepG2_Human1.02807852
99AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02691161
100EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02603404
101TBL1_22424771_ChIP-Seq_293T_Human1.01420368
102* FOXO3_23340844_ChIP-Seq_DLD1_Human1.01044428
103CDX2_20551321_ChIP-Seq_CACO-2_Human1.00834019
104EZH2_27294783_Chip-Seq_NPCs_Mouse1.00341797
105JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00123002
106ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99994231
107* AR_20517297_ChIP-Seq_VCAP_Human0.98729419
108PHF8_20622853_ChIP-Seq_HELA_Human0.98325795
109ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98253853
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97554740
111FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96721168
112FOXA1_25329375_ChIP-Seq_VCAP_Human0.96721168
113NANOG_18555785_Chip-Seq_ESCs_Mouse0.96692603
114DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96546130
115ARNT_22903824_ChIP-Seq_MCF-7_Human0.96264541
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96216740
117NFE2_27457419_Chip-Seq_LIVER_Mouse0.96162624
118TP53_18474530_ChIP-ChIP_U2OS_Human0.95887705
119SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95715733
120HTT_18923047_ChIP-ChIP_STHdh_Human0.95291274
121PIAS1_25552417_ChIP-Seq_VCAP_Human0.94983740
122EP300_21415370_ChIP-Seq_HL-1_Mouse0.94479840
123SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92822413
124GATA1_22025678_ChIP-Seq_K562_Human0.92744697
125NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90753209
126NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90753209
127PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90554058
128TBX20_22328084_ChIP-Seq_HEART_Mouse0.90253149
129TBX20_22080862_ChIP-Seq_HEART_Mouse0.90253149
130CTCF_27219007_Chip-Seq_Bcells_Human0.88989053
131SMAD3_21741376_ChIP-Seq_HESCs_Human0.88325354
132CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88161602
133RACK7_27058665_Chip-Seq_MCF-7_Human0.87896757
134SMAD4_21741376_ChIP-Seq_HESCs_Human0.86868701
135EZH2_27294783_Chip-Seq_ESCs_Mouse0.86854983
136SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.86737933
137* SOX2_21211035_ChIP-Seq_LN229_Gbm0.86175224
138KDM2B_26808549_Chip-Seq_K562_Human0.86002972
139SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85006423
140TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.84620234
141REST_21632747_ChIP-Seq_MESCs_Mouse0.83560050
142SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.83530582
143NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83156379
144JARID2_20064375_ChIP-Seq_MESCs_Mouse0.82912035
145SMAD4_21799915_ChIP-Seq_A2780_Human0.82297614
146RUNX1_27514584_Chip-Seq_MCF-7_Human0.81092462
147NR3C1_23031785_ChIP-Seq_PC12_Mouse0.81035731
148REST_18959480_ChIP-ChIP_MESCs_Mouse0.80086717
149* GATA4_25053715_ChIP-Seq_YYC3_Human0.79648302
150LXR_22292898_ChIP-Seq_THP-1_Human0.79535459
151* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79015159
152TP53_16413492_ChIP-PET_HCT116_Human0.78670204
153RXR_22108803_ChIP-Seq_LS180_Human0.78512781
154* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.78038909
155CREB1_26743006_Chip-Seq_LNCaP_Human0.77651940
156CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.77438763
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76881582
158AR_19668381_ChIP-Seq_PC3_Human0.76637966
159CTNNB1_20460455_ChIP-Seq_HCT116_Human0.73668981
160SOX2_20726797_ChIP-Seq_SW620_Human0.73239919
161GATA6_25053715_ChIP-Seq_YYC3_Human0.73230273
162CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.73222092
163GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.72247988

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.76491196
2MP0002139_abnormal_hepatobiliary_system5.63818442
3MP0005085_abnormal_gallbladder_physiolo5.11921248
4MP0005365_abnormal_bile_salt4.39114002
5MP0008875_abnormal_xenobiotic_pharmacok3.85282930
6MP0010234_abnormal_vibrissa_follicle3.08331974
7MP0003252_abnormal_bile_duct3.00100250
8MP0003806_abnormal_nucleotide_metabolis2.85320820
9MP0010329_abnormal_lipoprotein_level2.75997355
10MP0005083_abnormal_biliary_tract2.53087283
11MP0002837_dystrophic_cardiac_calcinosis2.50769498
12MP0001666_abnormal_nutrient_absorption2.31015990
13MP0005332_abnormal_amino_acid2.22914239
14MP0000383_abnormal_hair_follicle2.16621392
15MP0003195_calcinosis2.02259210
16MP0004859_abnormal_synaptic_plasticity1.98292008
17MP0000751_myopathy1.95170499
18MP0009840_abnormal_foam_cell1.91892207
19MP0002796_impaired_skin_barrier1.89662485
20MP0002254_reproductive_system_inflammat1.85744271
21MP0003705_abnormal_hypodermis_morpholog1.84292954
22MP0003646_muscle_fatigue1.81088753
23MP0004130_abnormal_muscle_cell1.78250919
24MP0004019_abnormal_vitamin_homeostasis1.73596238
25MP0002118_abnormal_lipid_homeostasis1.68989377
26MP0003950_abnormal_plasma_membrane1.57818771
27MP0003191_abnormal_cellular_cholesterol1.56630235
28MP0005670_abnormal_white_adipose1.54966086
29MP0000579_abnormal_nail_morphology1.48873988
30MP0000566_synostosis1.47556473
31MP0004270_analgesia1.45022595
32MP0005319_abnormal_enzyme/_coenzyme1.41862490
33MP0000749_muscle_degeneration1.41098988
34MP0000609_abnormal_liver_physiology1.37962137
35MP0004036_abnormal_muscle_relaxation1.37331361
36MP0000747_muscle_weakness1.37198303
37MP0002269_muscular_atrophy1.35739603
38MP0004145_abnormal_muscle_electrophysio1.35671656
39MP0000013_abnormal_adipose_tissue1.34869317
40MP0005646_abnormal_pituitary_gland1.34759673
41MP0003329_amyloid_beta_deposits1.25115150
42MP0004043_abnormal_pH_regulation1.22873493
43MP0002138_abnormal_hepatobiliary_system1.20513272
44MP0005584_abnormal_enzyme/coenzyme_acti1.17360180
45MP0004215_abnormal_myocardial_fiber1.15923858
46MP0003868_abnormal_feces_composition1.15759423
47MP0002234_abnormal_pharynx_morphology1.15697700
48MP0005551_abnormal_eye_electrophysiolog1.13904069
49MP0005330_cardiomyopathy1.13557337
50MP0004087_abnormal_muscle_fiber1.12696585
51MP0004484_altered_response_of1.11928363
52MP0002108_abnormal_muscle_morphology1.09735277
53MP0009780_abnormal_chondrocyte_physiolo1.08204037
54MP0005620_abnormal_muscle_contractility1.06336816
55MP0002909_abnormal_adrenal_gland1.05930852
56MP0003718_maternal_effect1.05747868
57MP0000604_amyloidosis1.03442424
58MP0002822_catalepsy1.02185526
59MP0003045_fibrosis1.01798758
60MP0004264_abnormal_extraembryonic_tissu1.01610125
61MP0003635_abnormal_synaptic_transmissio1.01489521
62MP0004084_abnormal_cardiac_muscle1.00425478
63MP0002098_abnormal_vibrissa_morphology0.99419261
64MP0009643_abnormal_urine_homeostasis0.98981302
65MP0000003_abnormal_adipose_tissue0.98682742
66MP0004858_abnormal_nervous_system0.98421272
67MP0006036_abnormal_mitochondrial_physio0.97594227
68MP0001944_abnormal_pancreas_morphology0.96234488
69MP0005645_abnormal_hypothalamus_physiol0.94272785
70MP0005451_abnormal_body_composition0.94195246
71MP0002160_abnormal_reproductive_system0.93239571
72MP0004185_abnormal_adipocyte_glucose0.91840158
73MP0010678_abnormal_skin_adnexa0.91833685
74MP0001765_abnormal_ion_homeostasis0.91468872
75MP0001661_extended_life_span0.90142460
76MP0005666_abnormal_adipose_tissue0.89216379
77MP0005535_abnormal_body_temperature0.87616686
78MP0005395_other_phenotype0.86784048
79MP0002168_other_aberrant_phenotype0.85075004
80MP0003880_abnormal_central_pattern0.85032205
81MP0002078_abnormal_glucose_homeostasis0.82411739
82MP0002063_abnormal_learning/memory/cond0.80242812
83MP0003011_delayed_dark_adaptation0.79778425
84MP0005636_abnormal_mineral_homeostasis0.79602033
85MP0009745_abnormal_behavioral_response0.79231462
86MP0008961_abnormal_basal_metabolism0.78996013
87MP0000467_abnormal_esophagus_morphology0.78552056
88MP0008874_decreased_physiological_sensi0.78417902
89MP0002106_abnormal_muscle_physiology0.78194290
90MP0009046_muscle_twitch0.77589410
91MP0001501_abnormal_sleep_pattern0.76628788
92MP0005501_abnormal_skin_physiology0.75324646
93MP0005647_abnormal_sex_gland0.75182081
94MP0002971_abnormal_brown_adipose0.74648024
95MP0003953_abnormal_hormone_level0.74593128
96MP0000427_abnormal_hair_cycle0.74040620
97MP0005275_abnormal_skin_tensile0.74022818
98MP0005266_abnormal_metabolism0.73785350
99MP0000759_abnormal_skeletal_muscle0.73340242
100MP0003941_abnormal_skin_development0.73293643
101MP0002972_abnormal_cardiac_muscle0.72661117
102MP0010386_abnormal_urinary_bladder0.72364237
103MP0002693_abnormal_pancreas_physiology0.72161379
104MP0001664_abnormal_digestion0.72021169
105MP0002876_abnormal_thyroid_physiology0.71843312
106MP0002332_abnormal_exercise_endurance0.71792007
107MP0005166_decreased_susceptibility_to0.69592553
108MP0003075_altered_response_to0.68908363
109MP0001764_abnormal_homeostasis0.68628099
110MP0008872_abnormal_physiological_respon0.67778337
111MP0005187_abnormal_penis_morphology0.67218209
112MP0001756_abnormal_urination0.66682793
113MP0001485_abnormal_pinna_reflex0.66237532
114MP0004233_abnormal_muscle_weight0.65920070
115MP0002127_abnormal_cardiovascular_syste0.65635076
116MP0001440_abnormal_grooming_behavior0.64414059
117MP0000569_abnormal_digit_pigmentation0.64404794
118MP0005386_behavior/neurological_phenoty0.64281695
119MP0004924_abnormal_behavior0.64281695
120MP0005448_abnormal_energy_balance0.63981941
121MP0003879_abnormal_hair_cell0.62940128
122MP0005369_muscle_phenotype0.62682420
123MP0002064_seizures0.62441851
124MP0006138_congestive_heart_failure0.61062092
125MP0006035_abnormal_mitochondrial_morpho0.60986118
126MP0004085_abnormal_heartbeat0.60959372
127MP0000538_abnormal_urinary_bladder0.60619260
128MP0000230_abnormal_systemic_arterial0.59410518
129MP0002735_abnormal_chemical_nociception0.58152502
130MP0005165_increased_susceptibility_to0.57848189
131MP0008775_abnormal_heart_ventricle0.57670609
132MP0003137_abnormal_impulse_conducting0.57388985
133MP0001984_abnormal_olfaction0.57284533

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.05105702
2Deep venous thrombosis (HP:0002625)4.72328252
3Abnormality of monocarboxylic acid metabolism (HP:0010996)4.42053618
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.26964977
5Xanthomatosis (HP:0000991)4.20160118
6Right ventricular cardiomyopathy (HP:0011663)4.10834024
7Hypobetalipoproteinemia (HP:0003563)3.96757396
8Exercise-induced myalgia (HP:0003738)3.73431730
9Hyperammonemia (HP:0001987)3.61521176
10Ketosis (HP:0001946)3.60543538
11Complement deficiency (HP:0004431)3.51234084
12Abnormality of glutamine family amino acid metabolism (HP:0010902)3.46953372
13Prolonged partial thromboplastin time (HP:0003645)3.45239079
14Hyperglycinemia (HP:0002154)3.42200737
15Hyperglycinuria (HP:0003108)3.41338763
16Hypolipoproteinemia (HP:0010981)3.38618889
17Hyporeflexia of lower limbs (HP:0002600)3.33355379
18Hypoalphalipoproteinemia (HP:0003233)3.29492298
19Gout (HP:0001997)3.27936758
20Hyperkalemia (HP:0002153)3.27741489
21Exercise-induced muscle cramps (HP:0003710)3.27541104
22Muscle fiber inclusion bodies (HP:0100299)3.22539881
23Hyperlipoproteinemia (HP:0010980)3.21143732
24Epidermoid cyst (HP:0200040)3.20049328
25Abnormality of serine family amino acid metabolism (HP:0010894)3.18699867
26Abnormality of glycine metabolism (HP:0010895)3.18699867
27Ketoacidosis (HP:0001993)3.18046502
28Myoglobinuria (HP:0002913)3.16558261
29Hypoglycemic coma (HP:0001325)3.00333594
30Sudden death (HP:0001699)2.94775858
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.91718143
32Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.91089181
33Hyperactive renin-angiotensin system (HP:0000841)2.90314340
34Abnormality of sulfur amino acid metabolism (HP:0004339)2.89356501
35Fat malabsorption (HP:0002630)2.83953755
36Abnormality of aspartate family amino acid metabolism (HP:0010899)2.75967168
37Calf muscle hypertrophy (HP:0008981)2.73812998
38Muscle hypertrophy of the lower extremities (HP:0008968)2.71366653
39Hyperglycemia (HP:0003074)2.68915523
40Abnormality of the common coagulation pathway (HP:0010990)2.67889651
41Fair hair (HP:0002286)2.66002553
42Nemaline bodies (HP:0003798)2.62015397
43Abnormal ciliary motility (HP:0012262)2.60158854
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.59739542
45Abnormality of purine metabolism (HP:0004352)2.59293790
46Absent/shortened dynein arms (HP:0200106)2.57497206
47Dynein arm defect of respiratory motile cilia (HP:0012255)2.57497206
48Decreased circulating renin level (HP:0003351)2.56935036
49Proximal tubulopathy (HP:0000114)2.56285181
50Type 1 muscle fiber predominance (HP:0003803)2.55957423
51Abnormality of the renal cortex (HP:0011035)2.55954124
52Abnormal respiratory motile cilium physiology (HP:0012261)2.50170754
53Abnormality of fatty-acid metabolism (HP:0004359)2.48696044
54Cholelithiasis (HP:0001081)2.48437056
55Abnormality of the Achilles tendon (HP:0005109)2.47117048
56Neonatal onset (HP:0003623)2.46493423
57Ventricular fibrillation (HP:0001663)2.46017071
58Gaze-evoked nystagmus (HP:0000640)2.41117177
59Increased connective tissue (HP:0009025)2.39954035
60Metabolic acidosis (HP:0001942)2.39840291
61Skin nodule (HP:0200036)2.37380513
62Focal motor seizures (HP:0011153)2.37346406
63Heart block (HP:0012722)2.36931313
64Abnormality of complement system (HP:0005339)2.36776469
65Abnormality of methionine metabolism (HP:0010901)2.36009147
66Hyperuricemia (HP:0002149)2.35963006
67Increased purine levels (HP:0004368)2.35963006
68Large for gestational age (HP:0001520)2.35734641
69Abnormality of renin-angiotensin system (HP:0000847)2.35638316
70Abnormality of potassium homeostasis (HP:0011042)2.35215481
71Abnormal respiratory motile cilium morphology (HP:0005938)2.34724241
72Abnormal respiratory epithelium morphology (HP:0012253)2.34724241
73Malnutrition (HP:0004395)2.34579105
74Conjugated hyperbilirubinemia (HP:0002908)2.33823031
75Abnormal gallbladder morphology (HP:0012437)2.33642956
76Abnormality of nucleobase metabolism (HP:0010932)2.32526746
77Difficulty running (HP:0009046)2.31974339
78Lip pit (HP:0100267)2.31684764
79Syncope (HP:0001279)2.30861716
80Abnormality of the intrinsic pathway (HP:0010989)2.28694221
81Popliteal pterygium (HP:0009756)2.27876335
82Abnormal gallbladder physiology (HP:0012438)2.26240752
83Cholecystitis (HP:0001082)2.26240752
84Delayed CNS myelination (HP:0002188)2.25951237
85Insulin-resistant diabetes mellitus (HP:0000831)2.25916914
86Generalized aminoaciduria (HP:0002909)2.25775989
87Muscle fiber splitting (HP:0003555)2.24780261
88Pancreatic cysts (HP:0001737)2.24681899
89Genetic anticipation (HP:0003743)2.20935699
90EMG: myopathic abnormalities (HP:0003458)2.17800939
91Distal arthrogryposis (HP:0005684)2.17344290
92Myopathic facies (HP:0002058)2.16524097
93Ventricular tachycardia (HP:0004756)2.16486644
94Increased circulating renin level (HP:0000848)2.15743238
95Bundle branch block (HP:0011710)2.15355363
96Rhinitis (HP:0012384)2.15218307
97Abnormality of serum amino acid levels (HP:0003112)2.13809457
98Abnormality of the lower motor neuron (HP:0002366)2.13370929
99Abnormal atrioventricular conduction (HP:0005150)2.13326252
100Rimmed vacuoles (HP:0003805)2.12088738
101Tubular atrophy (HP:0000092)2.11980211
102Rhabdomyolysis (HP:0003201)2.10293266
103Renal cortical cysts (HP:0000803)2.10078633
104Hypercholesterolemia (HP:0003124)2.09962235
105Pancreatic fibrosis (HP:0100732)2.08471677
106Joint hemorrhage (HP:0005261)2.08298310
107Muscle stiffness (HP:0003552)2.06931246
108Hypokalemia (HP:0002900)2.06814335
109Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.06681449
110Ventricular arrhythmia (HP:0004308)2.06185905
111Dysmetric saccades (HP:0000641)2.05917276
112Spontaneous abortion (HP:0005268)2.03927228
113Status epilepticus (HP:0002133)2.03000804
114Achilles tendon contracture (HP:0001771)2.02341019
115Generalized hypopigmentation of hair (HP:0011358)2.02098443
116Abnormality of the calf musculature (HP:0001430)2.01856998
117Abnormality of the left ventricular outflow tract (HP:0011103)2.00753305
118Subaortic stenosis (HP:0001682)2.00753305
119Hydroxyprolinuria (HP:0003080)1.97845367
120Abnormality of proline metabolism (HP:0010907)1.97845367
121Cardiovascular calcification (HP:0011915)1.96464153
122Distal lower limb muscle weakness (HP:0009053)1.95952077
123Hyperbilirubinemia (HP:0002904)1.95893703
124Palpitations (HP:0001962)1.95070913
125Sensorimotor neuropathy (HP:0007141)1.94467633
126Abnormality of chloride homeostasis (HP:0011422)1.92835541
127Myokymia (HP:0002411)1.92160133
128Lethargy (HP:0001254)1.91477821
129Hyperaldosteronism (HP:0000859)1.91349240
130Difficulty climbing stairs (HP:0003551)1.90822743
131Glycosuria (HP:0003076)1.90320662
132Abnormality of urine glucose concentration (HP:0011016)1.90320662
133Furrowed tongue (HP:0000221)1.89719520
134Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88529892
135Dicarboxylic aciduria (HP:0003215)1.88529892
136True hermaphroditism (HP:0010459)1.88408229
137Steatorrhea (HP:0002570)1.88292865
138Myotonia (HP:0002486)1.87863667
139Hypoglycemic seizures (HP:0002173)1.84367182
140Hyperinsulinemic hypoglycemia (HP:0000825)1.84181148
141Cystic liver disease (HP:0006706)1.83917581
142Chronic bronchitis (HP:0004469)1.83557794
143Vascular calcification (HP:0004934)1.82630587
144Hypomagnesemia (HP:0002917)1.82198142
145Late onset (HP:0003584)1.81433860
146Hyperphosphatemia (HP:0002905)1.81288453
147Hepatocellular carcinoma (HP:0001402)1.80800207
148Hypothermia (HP:0002045)1.80755323
149Hyperventilation (HP:0002883)1.79682005
150Chronic hepatic failure (HP:0100626)1.76739062
151Progressive cerebellar ataxia (HP:0002073)1.75553966
152Amelogenesis imperfecta (HP:0000705)1.70915532
153Abnormality of the renal medulla (HP:0100957)1.70814175
154Polydipsia (HP:0001959)1.70006184
155Abnormal drinking behavior (HP:0030082)1.70006184
156Neck muscle weakness (HP:0000467)1.69817779

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN3.10294862
2BCKDK2.85185759
3MAP2K42.65720502
4MAP3K92.48651258
5BMPR1B2.42329380
6EPHA42.36185673
7TTN2.30266699
8NTRK32.25146173
9DAPK22.14859924
10MET2.11723930
11TRPM72.11045916
12LMTK22.06102191
13PHKG21.96693837
14PHKG11.96693837
15KSR21.91174838
16NEK11.84515676
17STK391.84102577
18MAP3K21.83783672
19PKN21.80842832
20MAP3K41.80522979
21FER1.74809118
22FRK1.74554253
23TRIB31.72996033
24RIPK11.70221279
25PIK3CG1.68094430
26SIK11.65564767
27STK381.64188096
28LATS11.61027114
29ACVR1B1.60602958
30PDK31.59195268
31PDK41.59195268
32MUSK1.54186330
33LATS21.52601206
34GRK11.50822873
35EEF2K1.50264308
36FGFR41.49203124
37ERN11.41483136
38NTRK11.38181108
39NME11.36335793
40PINK11.35442532
41EPHA21.35292525
42MST1R1.34471558
43MST41.30183571
44PAK61.23119542
45BRSK21.16832185
46INSRR1.13117534
47ERBB41.11869160
48AKT31.09475213
49ADRBK21.06978301
50MINK11.06871105
51* MAP3K71.03893205
52STK38L1.03354314
53RET1.03159843
54PAK31.01619168
55ERBB31.01433139
56PDK21.01340840
57MAPKAPK31.01107286
58TAOK10.99940833
59CAMKK10.99459508
60PTK60.98941775
61STK30.93969623
62SGK30.92624265
63MAP3K10.92029770
64STK240.91861457
65PRKCE0.87036146
66DMPK0.85850797
67MAP2K60.85646194
68MAP4K20.84898986
69MAP2K10.84882983
70RPS6KB20.83327229
71PRKD30.82492042
72MAPK110.81587139
73CAMK1D0.78071177
74PDPK10.77903029
75CAMK2G0.77299650
76MAP3K30.76749475
77PRKCI0.73365996
78CAMK2D0.73048588
79MAP2K70.72757174
80PRKAA20.72353944
81MAPK150.72292407
82MAP2K30.71823104
83FGFR30.71479694
84KSR10.71071337
85FGFR20.70532172
86MAPK120.69440617
87PTK20.68160672
88TAOK30.66047363
89DAPK10.65987576
90PDK10.65961024
91CASK0.65394209
92PRKAA10.65130866
93MAPKAPK50.64766930
94SGK20.64680242
95OXSR10.64658393
96MAP3K120.63399577
97WNK40.60757176
98PDGFRA0.60051453
99STK110.59106718
100EIF2AK30.57099086
101MAPK130.56132438
102BCR0.55899458
103MAP3K50.55743292
104CAMK2A0.55721723
105MAP3K130.55499819
106TGFBR10.54775162
107JAK20.53511706
108CDK50.53322011
109EPHA30.53306915
110PIK3CA0.52716011
111TNK20.52685637
112PNCK0.52612500
113SGK2230.52148234
114SGK4940.52148234
115CAMK10.51201988
116SGK10.51003174
117PRKCG0.50873731
118GRK50.50763189
119NEK60.50111349
120NLK0.50098539
121MAP3K110.49683235
122RPS6KB10.48154309
123ERBB20.48034094
124FGFR10.47403009
125RIPK40.46741472
126BMX0.45267190
127CAMK40.45177072
128MYLK0.45140669
129PTK2B0.44658407
130ZAK0.44104814
131PRKACG0.43562323
132PRKACA0.42477806
133AKT20.42279408
134CAMK1G0.40660502
135WNK30.40565600
136PRKCZ0.40432045
137MTOR0.39971974
138PRKG10.39847989
139WNK10.34299866
140ADRBK10.33393712
141PBK0.31193184
142CDK190.30109089
143MELK0.29551158

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.89262150
2Nitrogen metabolism_Homo sapiens_hsa009103.73849298
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.33469209
4Arginine biosynthesis_Homo sapiens_hsa002203.04749606
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.65030454
6Fatty acid degradation_Homo sapiens_hsa000712.38967017
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.21061386
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.20683528
9Tryptophan metabolism_Homo sapiens_hsa003802.17205137
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.10977748
11Linoleic acid metabolism_Homo sapiens_hsa005912.00357435
12Propanoate metabolism_Homo sapiens_hsa006401.99437183
13Butanoate metabolism_Homo sapiens_hsa006501.90489287
14Bile secretion_Homo sapiens_hsa049761.79389486
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.78413867
16Circadian rhythm_Homo sapiens_hsa047101.73549916
17Complement and coagulation cascades_Homo sapiens_hsa046101.73259714
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.72437463
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.70903587
20Fatty acid metabolism_Homo sapiens_hsa012121.63971574
21PPAR signaling pathway_Homo sapiens_hsa033201.62756954
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.62708929
23Starch and sucrose metabolism_Homo sapiens_hsa005001.57584609
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.57013060
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.55163424
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54116828
27Peroxisome_Homo sapiens_hsa041461.46462506
28beta-Alanine metabolism_Homo sapiens_hsa004101.43284218
29Phenylalanine metabolism_Homo sapiens_hsa003601.40176241
30Pyruvate metabolism_Homo sapiens_hsa006201.39908157
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38514836
32Chemical carcinogenesis_Homo sapiens_hsa052041.37537679
33Carbon metabolism_Homo sapiens_hsa012001.33547269
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.32777846
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30451820
36Histidine metabolism_Homo sapiens_hsa003401.29626958
37Fat digestion and absorption_Homo sapiens_hsa049751.23897433
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.17755829
39Biosynthesis of amino acids_Homo sapiens_hsa012301.16215084
40Caffeine metabolism_Homo sapiens_hsa002321.14493417
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05993825
42Ovarian steroidogenesis_Homo sapiens_hsa049131.05629669
43Sulfur metabolism_Homo sapiens_hsa009201.04179768
44Tyrosine metabolism_Homo sapiens_hsa003501.04116330
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.01982831
46Retinol metabolism_Homo sapiens_hsa008301.00938049
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00699355
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99219803
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98357851
50ABC transporters_Homo sapiens_hsa020100.97762440
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.96440086
52Arachidonic acid metabolism_Homo sapiens_hsa005900.92562785
53Vitamin B6 metabolism_Homo sapiens_hsa007500.89855471
54Selenocompound metabolism_Homo sapiens_hsa004500.86704004
55Ether lipid metabolism_Homo sapiens_hsa005650.84793613
56Phototransduction_Homo sapiens_hsa047440.83129405
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.81806478
58Fatty acid biosynthesis_Homo sapiens_hsa000610.80696692
59Mineral absorption_Homo sapiens_hsa049780.79753658
60Arginine and proline metabolism_Homo sapiens_hsa003300.79689665
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78799484
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78266473
63Sphingolipid metabolism_Homo sapiens_hsa006000.76299208
64Glucagon signaling pathway_Homo sapiens_hsa049220.73864101
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72682155
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70645875
67Glycerolipid metabolism_Homo sapiens_hsa005610.68625965
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68148237
69Vitamin digestion and absorption_Homo sapiens_hsa049770.68084722
70Fructose and mannose metabolism_Homo sapiens_hsa000510.65860811
71Lysine degradation_Homo sapiens_hsa003100.65590245
72Gastric acid secretion_Homo sapiens_hsa049710.65554728
73Salivary secretion_Homo sapiens_hsa049700.61893423
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61317373
75Insulin resistance_Homo sapiens_hsa049310.60537050
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59985729
77Staphylococcus aureus infection_Homo sapiens_hsa051500.59821165
78Tight junction_Homo sapiens_hsa045300.59581850
79Insulin secretion_Homo sapiens_hsa049110.59113325
80Fatty acid elongation_Homo sapiens_hsa000620.57448064
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.57318555
82Galactose metabolism_Homo sapiens_hsa000520.56619709
83Nicotine addiction_Homo sapiens_hsa050330.55669067
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54889868
85Synaptic vesicle cycle_Homo sapiens_hsa047210.53596508
86Regulation of autophagy_Homo sapiens_hsa041400.53441913
87Metabolic pathways_Homo sapiens_hsa011000.53419858
88Long-term potentiation_Homo sapiens_hsa047200.53190258
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.53146957
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52078472
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51893098
92Cardiac muscle contraction_Homo sapiens_hsa042600.48897226
93Dilated cardiomyopathy_Homo sapiens_hsa054140.48248940
94Type II diabetes mellitus_Homo sapiens_hsa049300.46202367
95GABAergic synapse_Homo sapiens_hsa047270.46058857
96Serotonergic synapse_Homo sapiens_hsa047260.45759951
97Insulin signaling pathway_Homo sapiens_hsa049100.45126823
98Circadian entrainment_Homo sapiens_hsa047130.44203019
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42823541
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.41649299
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41189844
102Dorso-ventral axis formation_Homo sapiens_hsa043200.40860672
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40500313
104GnRH signaling pathway_Homo sapiens_hsa049120.40061971
105Renin secretion_Homo sapiens_hsa049240.39789966
106Calcium signaling pathway_Homo sapiens_hsa040200.39406215
107Oxytocin signaling pathway_Homo sapiens_hsa049210.38872863
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38761033
109Olfactory transduction_Homo sapiens_hsa047400.38323445
110AMPK signaling pathway_Homo sapiens_hsa041520.36796438
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.36380691
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35595219
113Amphetamine addiction_Homo sapiens_hsa050310.35488689
114Glutathione metabolism_Homo sapiens_hsa004800.35281853
115Folate biosynthesis_Homo sapiens_hsa007900.35094362
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34676874
117Thyroid hormone synthesis_Homo sapiens_hsa049180.33983525
118Pancreatic secretion_Homo sapiens_hsa049720.33453050
119Prion diseases_Homo sapiens_hsa050200.33071682
120Glutamatergic synapse_Homo sapiens_hsa047240.31818034
121Pentose phosphate pathway_Homo sapiens_hsa000300.27499911
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.26779537
123Taste transduction_Homo sapiens_hsa047420.26697622

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