PTPN21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)4.01417351
2plasma membrane repair (GO:0001778)3.86802014
3regulation of cardioblast differentiation (GO:0051890)3.84362518
4regulation of hippo signaling (GO:0035330)3.78484168
5fibroblast migration (GO:0010761)3.77551763
6mitotic metaphase plate congression (GO:0007080)3.56293475
7histone H2A monoubiquitination (GO:0035518)3.52391320
8sarcomere organization (GO:0045214)3.50457834
9regulation of transforming growth factor beta2 production (GO:0032909)3.47762875
10intestinal epithelial cell development (GO:0060576)3.40570026
11notochord development (GO:0030903)3.37585762
12cardiac muscle cell development (GO:0055013)3.31201065
13regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.31057940
14regulation of mitotic spindle organization (GO:0060236)3.30058805
15regulation of spindle organization (GO:0090224)3.22621774
16bundle of His cell to Purkinje myocyte communication (GO:0086069)3.21322124
17planar cell polarity pathway involved in neural tube closure (GO:0090179)3.20564656
18regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.20434703
19hemidesmosome assembly (GO:0031581)3.17946644
20cardiac cell development (GO:0055006)3.16405414
21carnitine shuttle (GO:0006853)3.12103499
22negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.10240182
23cardiac myofibril assembly (GO:0055003)3.10160130
24collagen fibril organization (GO:0030199)3.10086207
25ventricular cardiac muscle cell development (GO:0055015)3.09261382
26actin-mediated cell contraction (GO:0070252)3.03827949
27regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.03756934
28muscle filament sliding (GO:0030049)3.02933661
29actin-myosin filament sliding (GO:0033275)3.02933661
30epithelial cell-cell adhesion (GO:0090136)2.99918321
31negative regulation of fatty acid biosynthetic process (GO:0045717)2.96258764
32negative regulation of protein localization to cell surface (GO:2000009)2.94383183
33regulation of female gonad development (GO:2000194)2.92353882
34monoubiquitinated protein deubiquitination (GO:0035520)2.91878696
35desmosome organization (GO:0002934)2.89202570
36negative regulation of smooth muscle cell differentiation (GO:0051151)2.85391540
37mitotic chromosome condensation (GO:0007076)2.84850367
38protein heterotrimerization (GO:0070208)2.82205158
39histone H2A ubiquitination (GO:0033522)2.80621268
40cell migration involved in heart development (GO:0060973)2.79372813
41sequestering of extracellular ligand from receptor (GO:0035581)2.78949098
42bone trabecula formation (GO:0060346)2.78668834
43fatty acid transmembrane transport (GO:1902001)2.75749195
44regulation of cholesterol homeostasis (GO:2000188)2.74376422
45metaphase plate congression (GO:0051310)2.71888155
46axon extension involved in axon guidance (GO:0048846)2.71566294
47neuron projection extension involved in neuron projection guidance (GO:1902284)2.71566294
48skin morphogenesis (GO:0043589)2.65867735
49myoblast fusion (GO:0007520)2.65745206
50cell-substrate junction assembly (GO:0007044)2.64300992
51oocyte maturation (GO:0001556)2.63643281
52hippo signaling (GO:0035329)2.63634411
53myofibril assembly (GO:0030239)2.63622130
54kidney mesenchyme development (GO:0072074)2.62145850
55DNA damage induced protein phosphorylation (GO:0006975)2.60170507
56metanephric mesenchyme development (GO:0072075)2.58471383
57negative regulation of chondrocyte differentiation (GO:0032331)2.56890715
58camera-type eye morphogenesis (GO:0048593)2.56821747
59piRNA metabolic process (GO:0034587)2.56580548
60actin filament-based movement (GO:0030048)2.56560031
61extracellular matrix assembly (GO:0085029)2.55749673
62regulation of axon extension involved in axon guidance (GO:0048841)2.54510468
63Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.52427541
64chondrocyte proliferation (GO:0035988)2.51430495
65columnar/cuboidal epithelial cell development (GO:0002066)2.51276441
66ventricular cardiac muscle cell action potential (GO:0086005)2.50667180
67positive regulation of Cdc42 GTPase activity (GO:0043089)2.50619208
68retina vasculature morphogenesis in camera-type eye (GO:0061299)2.49104856
69cytoplasmic mRNA processing body assembly (GO:0033962)2.49016406
70negative regulation of fatty acid metabolic process (GO:0045922)2.47260701
71actomyosin structure organization (GO:0031032)2.46795327
72cell migration involved in sprouting angiogenesis (GO:0002042)2.46149840
73regulation of establishment of planar polarity (GO:0090175)2.45159237
74lymphangiogenesis (GO:0001946)2.44092571
75regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.44072204
76female gamete generation (GO:0007292)2.43346424
77regulation of Cdc42 GTPase activity (GO:0043088)2.39707069
78negative regulation of axon extension involved in axon guidance (GO:0048843)2.38450870
79mitotic nuclear envelope disassembly (GO:0007077)2.37788857
80axon extension (GO:0048675)2.37091953
81regulation of skeletal muscle contraction (GO:0014819)2.36338148
82regulation of meiosis (GO:0040020)2.36060815
83pericardium development (GO:0060039)2.35535343
84biotin metabolic process (GO:0006768)2.35168981
85COPII vesicle coating (GO:0048208)2.35141671
86vitamin transmembrane transport (GO:0035461)2.35040620
87myelination in peripheral nervous system (GO:0022011)2.34236771
88peripheral nervous system axon ensheathment (GO:0032292)2.34236771
89regulation of axon guidance (GO:1902667)2.33804161
90apical protein localization (GO:0045176)2.32752589
91sulfur amino acid catabolic process (GO:0000098)2.31463142
92tight junction assembly (GO:0070830)2.31446338
93negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.31388948
94gene silencing by RNA (GO:0031047)2.31338513
95embryonic foregut morphogenesis (GO:0048617)2.31212065
96cochlea morphogenesis (GO:0090103)2.31137661
97regulation of sister chromatid cohesion (GO:0007063)2.30978079
98membrane disassembly (GO:0030397)2.30649322
99nuclear envelope disassembly (GO:0051081)2.30649322
100embryonic retina morphogenesis in camera-type eye (GO:0060059)2.30408461
101outflow tract septum morphogenesis (GO:0003148)2.30370110
102glomerular basement membrane development (GO:0032836)2.29444804
103type B pancreatic cell development (GO:0003323)2.28494040
104establishment of planar polarity (GO:0001736)2.28395093
105establishment of tissue polarity (GO:0007164)2.28395093
106myoblast migration (GO:0051451)2.28110093
107negative regulation of fatty acid transport (GO:2000192)2.27944004
108dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.27467848
109regulation of the force of heart contraction (GO:0002026)2.26905438
110regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.26706207
111syncytium formation by plasma membrane fusion (GO:0000768)2.25628512
112cytoskeletal anchoring at plasma membrane (GO:0007016)2.25604352
113positive regulation of epithelial to mesenchymal transition (GO:0010718)2.24869330
114regulation of retinoic acid receptor signaling pathway (GO:0048385)2.24738770
115cell adhesion mediated by integrin (GO:0033627)2.24278918
116regulation of tight junction assembly (GO:2000810)2.23870268
117non-canonical Wnt signaling pathway (GO:0035567)2.23647044
118artery development (GO:0060840)2.23017373
119DNA damage response, signal transduction resulting in transcription (GO:0042772)2.22941445
120regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.22058168
121negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.21828683
122endocardial cushion development (GO:0003197)2.21362570
123carnitine transmembrane transport (GO:1902603)2.21326331
124smooth muscle tissue development (GO:0048745)2.21176042
125endothelial cell morphogenesis (GO:0001886)2.20781095
126negative regulation of potassium ion transmembrane transport (GO:1901380)2.19489913
127cell communication involved in cardiac conduction (GO:0086065)2.19299994
128basement membrane organization (GO:0071711)2.18557426
129adherens junction assembly (GO:0034333)2.18463781
130nuclear envelope organization (GO:0006998)2.18425713
131wound healing, spreading of cells (GO:0044319)2.18216207
132negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.17367731
133negative regulation of DNA-templated transcription, elongation (GO:0032785)2.17367731
134atrial septum morphogenesis (GO:0060413)2.17274943
135positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.16581665
136regulation of sequestering of triglyceride (GO:0010889)2.16195754
137negative regulation of cell size (GO:0045792)2.15911666
138cell-substrate adherens junction assembly (GO:0007045)2.15788566
139focal adhesion assembly (GO:0048041)2.15788566
140regulation of integrin-mediated signaling pathway (GO:2001044)2.15616071
141vascular endothelial growth factor signaling pathway (GO:0038084)2.15475914
142regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.15273749
143DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.15184134
144endodermal cell differentiation (GO:0035987)2.15096850
145intracellular lipid transport (GO:0032365)2.14928357
146amino-acid betaine transport (GO:0015838)2.14499416
147carnitine transport (GO:0015879)2.14499416
148negative regulation of cardiac muscle tissue development (GO:0055026)2.14449962
149atrioventricular valve morphogenesis (GO:0003181)2.13510662
150cell communication by electrical coupling (GO:0010644)2.13106061
151extracellular fibril organization (GO:0043206)2.12179968
152positive regulation of fatty acid beta-oxidation (GO:0032000)2.11953066
153axonal fasciculation (GO:0007413)2.11375794
154negative regulation of catenin import into nucleus (GO:0035414)2.11331686
155negative regulation of cardiac muscle tissue growth (GO:0055022)2.11108868
156negative regulation of heart growth (GO:0061117)2.11108868
157neuron projection extension (GO:1990138)2.10478320
158collagen metabolic process (GO:0032963)2.10412254
159meiotic cell cycle (GO:0051321)2.10302013
160peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.09751205
161substrate adhesion-dependent cell spreading (GO:0034446)2.09686081
162actin filament depolymerization (GO:0030042)2.09439099
163negative regulation of axon guidance (GO:1902668)2.09370141
164positive regulation of p38MAPK cascade (GO:1900745)2.09268604
165gap junction assembly (GO:0016264)2.08188311
166convergent extension (GO:0060026)2.06572644

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.76105863
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.57101181
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.04881952
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.98962465
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.76318395
6AR_21909140_ChIP-Seq_LNCAP_Human2.68065849
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.63923206
8* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.56314732
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.55844108
10CLOCK_20551151_ChIP-Seq_293T_Human2.53958431
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.45221129
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.36636580
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.32734796
14EZH2_22144423_ChIP-Seq_EOC_Human2.19804319
15ATF3_27146783_Chip-Seq_COLON_Human2.19665368
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19590146
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.15220241
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.11406511
19ZNF263_19887448_ChIP-Seq_K562_Human2.11202564
20ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.09607270
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.07787049
22ESR1_20079471_ChIP-ChIP_T-47D_Human2.06765197
23FOXO3_23340844_ChIP-Seq_DLD1_Human2.00008535
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.99855658
25EP300_21415370_ChIP-Seq_HL-1_Mouse1.99840031
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96480541
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.95427132
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.93860922
29TBX20_22328084_ChIP-Seq_HEART_Mouse1.92297777
30TBX20_22080862_ChIP-Seq_HEART_Mouse1.92297777
31SALL4_18804426_ChIP-ChIP_XEN_Mouse1.90220186
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88746781
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.88308123
34EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.88103021
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84930041
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.83032637
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.80624220
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.77965578
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77226287
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77226287
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73946291
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64722418
43* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.64622449
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.64458485
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64264424
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.63973930
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.62991532
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62121017
49GATA6_25053715_ChIP-Seq_YYC3_Human1.61603214
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.60871051
51CJUN_26792858_Chip-Seq_BT549_Human1.60572486
52UBF1/2_26484160_Chip-Seq_HMECs_Human1.58198574
53FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.57071430
54TP53_18474530_ChIP-ChIP_U2OS_Human1.55684938
55SOX9_24532713_ChIP-Seq_HFSC_Mouse1.55468235
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.54837861
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54515508
58TRIM28_21343339_ChIP-Seq_HEK293_Human1.53866786
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53598101
60GBX2_23144817_ChIP-Seq_PC3_Human1.53358680
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52906967
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49993660
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48644812
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.45301943
65P300_27058665_Chip-Seq_ZR-75-30cells_Human1.45185410
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44546081
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42793442
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.42391088
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41544791
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39117375
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38216815
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38216815
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.37460577
74* AHR_22903824_ChIP-Seq_MCF-7_Human1.37051081
75RACK7_27058665_Chip-Seq_MCF-7_Human1.36313592
76* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36152333
77* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36152333
78MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36067562
79NFIB_24661679_ChIP-Seq_LUNG_Mouse1.35830037
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34172918
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33911248
82HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33613960
83* BRD4_25478319_ChIP-Seq_HGPS_Human1.32834423
84ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.31772477
85GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31667927
86JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30804532
87NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.30670421
88* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29558388
89CBX2_27304074_Chip-Seq_ESCs_Mouse1.29505638
90ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.29318560
91TP53_16413492_ChIP-PET_HCT116_Human1.29305314
92CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27771013
93* FOXA2_19822575_ChIP-Seq_HepG2_Human1.27015674
94GATA4_25053715_ChIP-Seq_YYC3_Human1.25762751
95SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.25328159
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24537936
97* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23599587
98* ARNT_22903824_ChIP-Seq_MCF-7_Human1.23308240
99ELK3_25401928_ChIP-Seq_HUVEC_Human1.22930207
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22596267
101* SMAD4_21799915_ChIP-Seq_A2780_Human1.21809098
102* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21250866
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21170920
104* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20517616
105SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18522430
106EZH2_27294783_Chip-Seq_ESCs_Mouse1.17914996
107* GATA3_24758297_ChIP-Seq_MCF-7_Human1.17105093
108* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17039408
109ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15947095
110SMAD3_21741376_ChIP-Seq_HESCs_Human1.15585490
111YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15551999
112TP53_20018659_ChIP-ChIP_R1E_Mouse1.14725996
113TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13698398
114FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.13632298
115RING1B_27294783_Chip-Seq_ESCs_Mouse1.13412192
116KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12105634
117ISL1_27105846_Chip-Seq_CPCs_Mouse1.11581501
118RING1B_27294783_Chip-Seq_NPCs_Mouse1.10206688
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09893749
120DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09829219
121* CHD1_26751641_Chip-Seq_LNCaP_Human1.08488837
122* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08364861
123* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.07645172
124FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07293530
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07069804
126* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07035734
127JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06812541
128TP63_19390658_ChIP-ChIP_HaCaT_Human1.06634316
129SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06275978
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05705238
131STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04682138
132TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04271645
133TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03888057
134POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03865925
135GATA2_21666600_ChIP-Seq_HMVEC_Human1.03736277
136OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03462080
137TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03074541
138PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02605253
139FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02498145
140TCF4_18268006_ChIP-ChIP_LS174T_Human1.00989656
141SMAD3_21741376_ChIP-Seq_EPCs_Human1.00674471
142TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00561048
143* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99787612
144JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99329155
145TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99322493
146FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99271785
147ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99271039
148* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98684379
149STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98628942
150NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97965815
151NANOG_21062744_ChIP-ChIP_HESCs_Human0.97351222
152TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97257114
153SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96696662
154SMAD4_21741376_ChIP-Seq_HESCs_Human0.94961672
155ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94794831
156NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94414655
157EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92644637
158CREB1_26743006_Chip-Seq_LNCaP_Human0.92628312
159TP63_22573176_ChIP-Seq_HFKS_Human0.91400055
160NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.90520235
161* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90448290
162KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87435511
163TP63_23658742_ChIP-Seq_EP156T_Human0.87123455
164CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.86740196

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.33512633
2MP0005503_abnormal_tendon_morphology2.95083360
3MP0005451_abnormal_body_composition2.86844559
4MP0002877_abnormal_melanocyte_morpholog2.75333467
5MP0001958_emphysema2.59819808
6MP0005275_abnormal_skin_tensile2.32828018
7MP0003646_muscle_fatigue2.23203804
8MP0004084_abnormal_cardiac_muscle2.07711759
9MP0003718_maternal_effect2.06988116
10MP0008438_abnormal_cutaneous_collagen2.05122442
11MP0002837_dystrophic_cardiac_calcinosis2.03099652
12MP0009780_abnormal_chondrocyte_physiolo2.02984188
13MP0010030_abnormal_orbit_morphology1.99791780
14MP0000750_abnormal_muscle_regeneration1.98947596
15MP0003950_abnormal_plasma_membrane1.85758072
16MP0001299_abnormal_eye_distance/1.78960845
17MP0004185_abnormal_adipocyte_glucose1.78360704
18MP0005365_abnormal_bile_salt1.76217114
19MP0002139_abnormal_hepatobiliary_system1.75574020
20MP0002108_abnormal_muscle_morphology1.73599076
21MP0010368_abnormal_lymphatic_system1.72586375
22MP0003566_abnormal_cell_adhesion1.69882794
23MP0000733_abnormal_muscle_development1.69332667
24MP0009384_cardiac_valve_regurgitation1.68665061
25MP0000749_muscle_degeneration1.65303599
26MP0004087_abnormal_muscle_fiber1.60102164
27MP0000579_abnormal_nail_morphology1.56937113
28MP0002653_abnormal_ependyma_morphology1.56156839
29MP0000534_abnormal_ureter_morphology1.55294104
30MP0002269_muscular_atrophy1.54870692
31MP0001346_abnormal_lacrimal_gland1.53978564
32MP0002060_abnormal_skin_morphology1.51984712
33MP0000751_myopathy1.50340341
34MP0003252_abnormal_bile_duct1.48672936
35MP0000762_abnormal_tongue_morphology1.43333865
36MP0004264_abnormal_extraembryonic_tissu1.42488635
37MP0005023_abnormal_wound_healing1.40083065
38MP0000013_abnormal_adipose_tissue1.39768876
39MP0010352_gastrointestinal_tract_polyps1.38599371
40MP0005395_other_phenotype1.36658616
41MP0003693_abnormal_embryo_hatching1.35742634
42MP0005330_cardiomyopathy1.35554668
43MP0004272_abnormal_basement_membrane1.32596455
44MP0004036_abnormal_muscle_relaxation1.32082087
45MP0009840_abnormal_foam_cell1.31277397
46MP0006138_congestive_heart_failure1.31074563
47MP0009250_abnormal_appendicular_skeleto1.29622875
48MP0005666_abnormal_adipose_tissue1.28334871
49MP0005409_darkened_coat_color1.26189938
50MP0003385_abnormal_body_wall1.26163808
51MP0001879_abnormal_lymphatic_vessel1.25341270
52MP0010630_abnormal_cardiac_muscle1.25248513
53MP0003942_abnormal_urinary_system1.25182955
54MP0009053_abnormal_anal_canal1.24632586
55MP0002896_abnormal_bone_mineralization1.23111518
56MP0005670_abnormal_white_adipose1.22978130
57MP0010234_abnormal_vibrissa_follicle1.21610111
58MP0004233_abnormal_muscle_weight1.21253992
59MP0000462_abnormal_digestive_system1.19477655
60MP0001542_abnormal_bone_strength1.18541110
61MP0002295_abnormal_pulmonary_circulatio1.18303255
62MP0003283_abnormal_digestive_organ1.17661356
63MP0002796_impaired_skin_barrier1.16918685
64MP0002106_abnormal_muscle_physiology1.16477247
65MP0002234_abnormal_pharynx_morphology1.16363390
66MP0005257_abnormal_intraocular_pressure1.14604098
67MP0003011_delayed_dark_adaptation1.12532805
68MP0005623_abnormal_meninges_morphology1.10445045
69MP0005620_abnormal_muscle_contractility1.07421225
70MP0000566_synostosis1.07189331
71MP0005408_hypopigmentation1.06725763
72MP0003937_abnormal_limbs/digits/tail_de1.06067403
73MP0005076_abnormal_cell_differentiation1.05848674
74MP0000759_abnormal_skeletal_muscle1.05280378
75MP0000537_abnormal_urethra_morphology1.05243844
76MP0005085_abnormal_gallbladder_physiolo1.05243264
77MP0002254_reproductive_system_inflammat1.02428902
78MP0004145_abnormal_muscle_electrophysio1.02129865
79MP0003453_abnormal_keratinocyte_physiol1.01683322
80MP0005360_urolithiasis1.01406884
81MP0005380_embryogenesis_phenotype1.00739210
82MP0001672_abnormal_embryogenesis/_devel1.00739210
83MP0003935_abnormal_craniofacial_develop0.98051611
84MP0001915_intracranial_hemorrhage0.97995912
85MP0000747_muscle_weakness0.96177981
86MP0003984_embryonic_growth_retardation0.95666225
87MP0002233_abnormal_nose_morphology0.95345810
88MP0005595_abnormal_vascular_smooth0.95136173
89MP0002972_abnormal_cardiac_muscle0.94871290
90MP0002138_abnormal_hepatobiliary_system0.94656722
91MP0002088_abnormal_embryonic_growth/wei0.94193451
92MP0005248_abnormal_Harderian_gland0.93960104
93MP0003941_abnormal_skin_development0.93936901
94MP0000049_abnormal_middle_ear0.93541012
95MP0003091_abnormal_cell_migration0.93198534
96MP0002697_abnormal_eye_size0.92929851
97MP0004130_abnormal_muscle_cell0.92612273
98MP0000767_abnormal_smooth_muscle0.92503715
99MP0006072_abnormal_retinal_apoptosis0.92486958
100MP0005369_muscle_phenotype0.91906299
101MP0001730_embryonic_growth_arrest0.91824386
102MP0002249_abnormal_larynx_morphology0.91641076
103MP0005375_adipose_tissue_phenotype0.91410728
104MP0000778_abnormal_nervous_system0.90285981
105MP0002084_abnormal_developmental_patter0.89032755
106MP0005220_abnormal_exocrine_pancreas0.88924042
107MP0001849_ear_inflammation0.88865750
108MP0005508_abnormal_skeleton_morphology0.88754133
109MP0003699_abnormal_female_reproductive0.88264351
110MP0005385_cardiovascular_system_phenoty0.87114363
111MP0001544_abnormal_cardiovascular_syste0.87114363
112MP0004215_abnormal_myocardial_fiber0.86468901
113MP0002085_abnormal_embryonic_tissue0.86148634
114MP0003279_aneurysm0.85083620
115MP0004957_abnormal_blastocyst_morpholog0.84487526
116MP0004085_abnormal_heartbeat0.84355463
117MP0000432_abnormal_head_morphology0.83868480
118MP0001697_abnormal_embryo_size0.83679957
119MP0002168_other_aberrant_phenotype0.82940085
120MP0002127_abnormal_cardiovascular_syste0.81039941
121MP0003111_abnormal_nucleus_morphology0.81031279
122MP0003567_abnormal_fetal_cardiomyocyte0.79639732
123MP0002116_abnormal_craniofacial_bone0.79496594
124MP0000467_abnormal_esophagus_morphology0.78734031
125MP0000003_abnormal_adipose_tissue0.78558566
126MP0003755_abnormal_palate_morphology0.78000115
127MP0008775_abnormal_heart_ventricle0.77584332
128MP0003868_abnormal_feces_composition0.77492415
129MP0003115_abnormal_respiratory_system0.76682827
130MP0004782_abnormal_surfactant_physiolog0.76615681
131MP0008007_abnormal_cellular_replicative0.76340468
132MP0001216_abnormal_epidermal_layer0.76319142
133MP0003077_abnormal_cell_cycle0.76062711
134MP0008875_abnormal_xenobiotic_pharmacok0.75380539
135MP0000266_abnormal_heart_morphology0.74799110
136MP0000428_abnormal_craniofacial_morphol0.74241001
137MP0000163_abnormal_cartilage_morphology0.74160391
138MP0002128_abnormal_blood_circulation0.74157226
139MP0005197_abnormal_uvea_morphology0.73957787
140MP0004858_abnormal_nervous_system0.73850289
141MP0002282_abnormal_trachea_morphology0.67573702
142MP0010678_abnormal_skin_adnexa0.67300633
143MP0002925_abnormal_cardiovascular_devel0.67219135
144MP0002932_abnormal_joint_morphology0.66943535
145MP0001243_abnormal_dermal_layer0.66794558
146MP0005187_abnormal_penis_morphology0.65027689
147MP0001614_abnormal_blood_vessel0.64058783

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.14215759
2Muscle fiber splitting (HP:0003555)4.06101828
3Right ventricular cardiomyopathy (HP:0011663)3.99168827
4Protrusio acetabuli (HP:0003179)3.93646273
5Increased connective tissue (HP:0009025)3.77672934
6Vascular tortuosity (HP:0004948)3.70525800
7Hyperglycemia (HP:0003074)3.54465432
8Arterial tortuosity (HP:0005116)3.47938386
9Male infertility (HP:0003251)3.45390063
10Insulin-resistant diabetes mellitus (HP:0000831)3.25061690
11Ankle contracture (HP:0006466)3.24994945
12Hyporeflexia of lower limbs (HP:0002600)3.17352672
13Type 1 muscle fiber predominance (HP:0003803)3.16324784
14Broad metatarsal (HP:0001783)3.15989575
15Neonatal short-limb short stature (HP:0008921)3.13668067
16Difficulty climbing stairs (HP:0003551)3.12164615
17Ventricular tachycardia (HP:0004756)2.99525685
18Chorioretinal atrophy (HP:0000533)2.97656177
19Soft skin (HP:0000977)2.87133176
20Shallow orbits (HP:0000586)2.83307178
21Short nail (HP:0001799)2.78807223
22Pigmentary retinal degeneration (HP:0001146)2.73323084
23Overgrowth (HP:0001548)2.64256709
24Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.62877672
25Deep venous thrombosis (HP:0002625)2.59985795
26Lip pit (HP:0100267)2.57121246
27Exercise-induced muscle cramps (HP:0003710)2.56873724
28Exercise-induced myalgia (HP:0003738)2.56859394
29Bladder diverticulum (HP:0000015)2.56479591
30Muscle fiber inclusion bodies (HP:0100299)2.55454450
31Natal tooth (HP:0000695)2.53710425
32Shawl scrotum (HP:0000049)2.53060323
33Sudden death (HP:0001699)2.48658753
34Wormian bones (HP:0002645)2.46672521
35Gout (HP:0001997)2.43703048
36Atrioventricular block (HP:0001678)2.43251593
37Abnormality of dentin (HP:0010299)2.41618791
38Atrophic scars (HP:0001075)2.39912491
39Abnormality of the left ventricular outflow tract (HP:0011103)2.38006065
40Subaortic stenosis (HP:0001682)2.38006065
41Bundle branch block (HP:0011710)2.35916732
42Wrist flexion contracture (HP:0001239)2.33391438
43Lipoatrophy (HP:0100578)2.31482757
44Limited hip movement (HP:0008800)2.29265181
45Aortic dissection (HP:0002647)2.27442257
46Cerebral aneurysm (HP:0004944)2.25411917
47Difficulty running (HP:0009046)2.24515001
48Aneurysm (HP:0002617)2.24490359
49Abnormality of the fingertips (HP:0001211)2.23970375
50Follicular hyperkeratosis (HP:0007502)2.23922428
51Mildly elevated creatine phosphokinase (HP:0008180)2.22820298
52Increased variability in muscle fiber diameter (HP:0003557)2.22245298
53Abnormal delivery (HP:0001787)2.20019077
54Round ear (HP:0100830)2.19737676
55Ulnar deviation of the wrist (HP:0003049)2.15780355
56Breech presentation (HP:0001623)2.15413281
57Wide anterior fontanel (HP:0000260)2.14084247
58Abnormal atrioventricular conduction (HP:0005150)2.12451467
59Papillary thyroid carcinoma (HP:0002895)2.12310804
60Genu recurvatum (HP:0002816)2.11366046
61Insulin resistance (HP:0000855)2.11115658
62Hip contracture (HP:0003273)2.09680464
63Posterior subcapsular cataract (HP:0007787)2.08931150
64Pendular nystagmus (HP:0012043)2.08563489
65Abnormality of the calf musculature (HP:0001430)2.08042974
66Congenital stationary night blindness (HP:0007642)2.06699374
67Coronal craniosynostosis (HP:0004440)2.05920163
68Asymmetric septal hypertrophy (HP:0001670)2.05451100
69Aortic aneurysm (HP:0004942)2.05309205
70Hypoplastic ischia (HP:0003175)2.04902774
71Neonatal death (HP:0003811)2.04055970
72Calcaneovalgus deformity (HP:0001848)2.03468007
73Advanced eruption of teeth (HP:0006288)2.03293916
74Long toe (HP:0010511)1.99155839
75Spinal rigidity (HP:0003306)1.98851864
76Areflexia of lower limbs (HP:0002522)1.97940933
77Abnormality of the calcaneus (HP:0008364)1.96967994
78Hyperextensible skin (HP:0000974)1.96561177
79Camptodactyly of toe (HP:0001836)1.96080928
80Cervical subluxation (HP:0003308)1.96037180
81Osteolytic defects of the hand bones (HP:0009699)1.95564775
82Osteolytic defects of the phalanges of the hand (HP:0009771)1.95564775
83Alopecia of scalp (HP:0002293)1.94410018
84Hypoalphalipoproteinemia (HP:0003233)1.94401866
85Focal segmental glomerulosclerosis (HP:0000097)1.92517731
86Nemaline bodies (HP:0003798)1.92062593
87Distal lower limb amyotrophy (HP:0008944)1.91420542
88EMG: myopathic abnormalities (HP:0003458)1.91299494
89Limb-girdle muscle weakness (HP:0003325)1.91082688
90Distal lower limb muscle weakness (HP:0009053)1.90800490
91Popliteal pterygium (HP:0009756)1.90371137
92Atrial fibrillation (HP:0005110)1.90145104
93Ventricular arrhythmia (HP:0004308)1.89769741
94Hyperglycinuria (HP:0003108)1.89494488
95Joint laxity (HP:0001388)1.89397835
96Aplasia of the musculature (HP:0100854)1.89289487
97Heart block (HP:0012722)1.89255293
98Mitral regurgitation (HP:0001653)1.89078951
99EMG: neuropathic changes (HP:0003445)1.88870348
100Fragile skin (HP:0001030)1.88041025
101Abnormality of skeletal muscle fiber size (HP:0012084)1.87681428
102Peritonitis (HP:0002586)1.87458322
103Hypoglycemic coma (HP:0001325)1.86704110
104Distal arthrogryposis (HP:0005684)1.83859436
105Bradycardia (HP:0001662)1.83110547
106Myoglobinuria (HP:0002913)1.82796414
107Abnormality of the neuromuscular junction (HP:0003398)1.81533911
108Fatigable weakness (HP:0003473)1.81533911
109Knee flexion contracture (HP:0006380)1.81411609
110Deformed tarsal bones (HP:0008119)1.80863498
111Bowel diverticulosis (HP:0005222)1.79867219
112Mitral valve prolapse (HP:0001634)1.78584760
113Abnormality of the ischium (HP:0003174)1.78058897
114Blue sclerae (HP:0000592)1.76808881
115Bony spicule pigmentary retinopathy (HP:0007737)1.76331561
116Primary atrial arrhythmia (HP:0001692)1.75535011
117Dilatation of the ascending aorta (HP:0005111)1.75283506
118Ulnar bowing (HP:0003031)1.74527821
119Vertebral arch anomaly (HP:0008438)1.74201571
120Dilated cardiomyopathy (HP:0001644)1.72885519
121Thin ribs (HP:0000883)1.72613186
122Scapular winging (HP:0003691)1.71685721
123Mitral stenosis (HP:0001718)1.71188258
124Abnormality of lateral ventricle (HP:0030047)1.69878983
125Subcapsular cataract (HP:0000523)1.69841256
126Ventricular fibrillation (HP:0001663)1.69798049
127Limb-girdle muscle atrophy (HP:0003797)1.69541073
128Calf muscle hypertrophy (HP:0008981)1.69243168
129Pterygium (HP:0001059)1.68491027
130Hyperglycinemia (HP:0002154)1.68476485
131Intrahepatic cholestasis (HP:0001406)1.68406972
132Infantile muscular hypotonia (HP:0008947)1.65981502
133Aortic regurgitation (HP:0001659)1.63334408
134Hypoplasia of the iris (HP:0007676)1.63115157
135Supraventricular arrhythmia (HP:0005115)1.62591792
136Cardiovascular calcification (HP:0011915)1.61821234
137Slender build (HP:0001533)1.60143636
138Morphological abnormality of the middle ear (HP:0008609)1.59408028
139Supraventricular tachycardia (HP:0004755)1.59019814
140Abnormality of the acetabulum (HP:0003170)1.56200758
141Pulmonary artery stenosis (HP:0004415)1.55783505
142Striae distensae (HP:0001065)1.53199487
143Tibial bowing (HP:0002982)1.52217591
144Osteoarthritis (HP:0002758)1.51727645
145Aplasia involving bones of the extremities (HP:0009825)1.51431258
146Aplasia involving bones of the upper limbs (HP:0009823)1.51431258
147Aplasia of the phalanges of the hand (HP:0009802)1.51431258

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.67502326
2LATS23.78853432
3STK38L3.62868441
4MYLK3.17707822
5TTN2.96193154
6TRIB32.86497487
7TAOK32.39796796
8PNCK2.33954788
9STK32.24689242
10EEF2K2.23103660
11MOS2.11399181
12NTRK12.06598912
13MET2.01658193
14TAOK11.99249680
15TTK1.92080815
16MARK11.84343551
17PKN21.82449425
18MAPKAPK31.80122173
19ERBB41.73026444
20CDK121.66665587
21LIMK11.63263479
22MAP3K61.59931402
23DMPK1.51764981
24EPHA21.49356212
25RPS6KA41.45348075
26PLK41.42443757
27LMTK21.41169628
28ERN11.40976992
29CASK1.39988947
30TGFBR21.36208360
31OBSCN1.36000280
32ICK1.32033638
33RIPK11.31168061
34NEK21.31113696
35PRKD31.28771876
36MUSK1.25555091
37TESK11.25432651
38MTOR1.18832079
39PDGFRA1.15341611
40STK381.14746991
41NEK11.12505031
42STK241.10770542
43CAMK1G1.10232298
44CDK81.09489198
45ROCK21.08612584
46TIE11.08522096
47RPS6KB21.08301745
48MST1R1.07827324
49EPHB11.06440563
50TNIK1.04590496
51PRKAA21.02831424
52PTK21.02245365
53NEK91.01451853
54MAP3K31.00422993
55EPHA40.98777371
56PRKAA10.96525626
57STK100.95854438
58MAP2K30.91211629
59BCR0.90539607
60PDK40.90204972
61PDK30.90204972
62MELK0.89944712
63PTK60.89054333
64CHEK20.88851534
65PRKD20.88271897
66SIK10.87401186
67CDK90.85848694
68KSR20.83283765
69WNK10.82740912
70FGFR40.79677899
71DDR20.79599684
72CDC70.79336546
73RPS6KA20.78774147
74TRPM70.78539758
75PIK3CA0.77494411
76BRAF0.77164289
77CDK40.74844634
78SGK20.74560401
79PIK3CG0.73805069
80PAK20.73280833
81SGK30.72860917
82AURKB0.72204568
83EPHB20.71540171
84SGK4940.71467179
85SGK2230.71467179
86NUAK10.70944136
87FGFR20.69784405
88MAP3K80.69554273
89MAPK150.69079056
90MAP3K70.67945444
91CAMK2D0.67433675
92PAK30.67169492
93PINK10.67117857
94CAMK2G0.65803806
95CHUK0.64810891
96KSR10.64314262
97PLK10.63287740
98ABL20.62912202
99PRKCE0.62883904
100CAMK1D0.61864181
101BCKDK0.60735673
102ZAK0.59547500
103MAP3K50.58559879
104CDK60.58319200
105CAMK2B0.57798696
106RAF10.57722448
107FGFR10.57428253
108PDK20.56674075
109PDGFRB0.54498934
110FER0.54388955
111GSK3A0.54255164
112MAP2K10.50909313
113BRSK20.50379552
114ERBB30.50296357
115DYRK1B0.50161359
116INSRR0.49843689
117RET0.49590624
118MAPK70.49160069
119BRD40.48195306
120PRKD10.47909206
121PAK40.46936951
122NTRK30.45736918
123FLT30.44562956
124CDK70.44463708
125AKT30.43582976
126MARK20.42842399
127BMX0.41950167
128MAP3K100.41109446
129CAMK2A0.40875526
130ILK0.40634525
131STK390.40236296
132CDC42BPA0.38974349
133MAPK110.38481952
134NTRK20.38318085
135LRRK20.38161184
136CAMK10.38040744
137EPHA30.37629022
138PAK60.37356171
139PHKG10.37318401
140PHKG20.37318401
141DAPK30.37254173
142MAP3K90.37122768
143ROCK10.36316428
144NLK0.35760640
145CHEK10.35709231
146TGFBR10.33697867

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007502.42156603
2Circadian rhythm_Homo sapiens_hsa047102.28927509
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.04999492
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.04418033
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.86113289
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.84223257
7Maturity onset diabetes of the young_Homo sapiens_hsa049501.77444982
8Adherens junction_Homo sapiens_hsa045201.77274684
9Dilated cardiomyopathy_Homo sapiens_hsa054141.76402315
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.75094378
11ECM-receptor interaction_Homo sapiens_hsa045121.71387281
12p53 signaling pathway_Homo sapiens_hsa041151.68985185
13Fatty acid degradation_Homo sapiens_hsa000711.65091093
14Ovarian steroidogenesis_Homo sapiens_hsa049131.61238117
15Phototransduction_Homo sapiens_hsa047441.58223266
16Lysine degradation_Homo sapiens_hsa003101.55873711
17Small cell lung cancer_Homo sapiens_hsa052221.55176853
18Cell cycle_Homo sapiens_hsa041101.52888066
19Axon guidance_Homo sapiens_hsa043601.52330450
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51280990
21Arginine biosynthesis_Homo sapiens_hsa002201.49581975
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.41486955
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40579182
24Folate biosynthesis_Homo sapiens_hsa007901.40447179
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37871171
26Starch and sucrose metabolism_Homo sapiens_hsa005001.35386328
27Focal adhesion_Homo sapiens_hsa045101.33520143
28TGF-beta signaling pathway_Homo sapiens_hsa043501.31597179
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29616739
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28974356
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27170144
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25393541
33Hippo signaling pathway_Homo sapiens_hsa043901.22747118
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21476570
35MicroRNAs in cancer_Homo sapiens_hsa052061.21476081
36RNA degradation_Homo sapiens_hsa030181.20021920
37Bladder cancer_Homo sapiens_hsa052191.19489021
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19222659
39Insulin resistance_Homo sapiens_hsa049311.19202500
40Melanogenesis_Homo sapiens_hsa049161.17935428
41Tryptophan metabolism_Homo sapiens_hsa003801.17267909
42Regulation of actin cytoskeleton_Homo sapiens_hsa048101.17248150
43Gap junction_Homo sapiens_hsa045401.16637230
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13904525
45Tight junction_Homo sapiens_hsa045301.13475449
46PPAR signaling pathway_Homo sapiens_hsa033201.10770755
47Biosynthesis of amino acids_Homo sapiens_hsa012301.10684656
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07379203
49Longevity regulating pathway - mammal_Homo sapiens_hsa042111.06781043
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06316399
51Linoleic acid metabolism_Homo sapiens_hsa005911.05316279
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05258927
53mTOR signaling pathway_Homo sapiens_hsa041501.04409764
54Fatty acid metabolism_Homo sapiens_hsa012121.03774576
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.02207014
56Vascular smooth muscle contraction_Homo sapiens_hsa042701.01916072
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98346364
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98258987
59Complement and coagulation cascades_Homo sapiens_hsa046100.97754437
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97600928
61Pancreatic cancer_Homo sapiens_hsa052120.97166434
62Wnt signaling pathway_Homo sapiens_hsa043100.96469558
63PI3K-Akt signaling pathway_Homo sapiens_hsa041510.95918768
64Protein digestion and absorption_Homo sapiens_hsa049740.95454464
65Propanoate metabolism_Homo sapiens_hsa006400.94965726
66Carbon metabolism_Homo sapiens_hsa012000.94719902
67Cardiac muscle contraction_Homo sapiens_hsa042600.94170816
68Renin secretion_Homo sapiens_hsa049240.93976758
69AMPK signaling pathway_Homo sapiens_hsa041520.93974558
70Amoebiasis_Homo sapiens_hsa051460.93589417
71Selenocompound metabolism_Homo sapiens_hsa004500.91935160
72Proteoglycans in cancer_Homo sapiens_hsa052050.90944776
73Galactose metabolism_Homo sapiens_hsa000520.90082785
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89355995
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89045390
76Glucagon signaling pathway_Homo sapiens_hsa049220.87561167
77Insulin signaling pathway_Homo sapiens_hsa049100.85992779
78FoxO signaling pathway_Homo sapiens_hsa040680.83739335
79Retinol metabolism_Homo sapiens_hsa008300.83595690
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82223092
81Nitrogen metabolism_Homo sapiens_hsa009100.82100032
82Histidine metabolism_Homo sapiens_hsa003400.81900245
83Insulin secretion_Homo sapiens_hsa049110.81369262
84RNA transport_Homo sapiens_hsa030130.80979575
85Vitamin digestion and absorption_Homo sapiens_hsa049770.80968679
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80841260
87Pathways in cancer_Homo sapiens_hsa052000.80184866
88Thyroid cancer_Homo sapiens_hsa052160.79822093
89Thyroid hormone synthesis_Homo sapiens_hsa049180.78356597
90Cocaine addiction_Homo sapiens_hsa050300.78109515
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77203097
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77180675
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76639852
94Melanoma_Homo sapiens_hsa052180.76013508
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.75857188
96beta-Alanine metabolism_Homo sapiens_hsa004100.75738343
97Phenylalanine metabolism_Homo sapiens_hsa003600.75267526
98Fat digestion and absorption_Homo sapiens_hsa049750.74320270
99Sulfur metabolism_Homo sapiens_hsa009200.73700436
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73496812
101Chronic myeloid leukemia_Homo sapiens_hsa052200.73143583
102cAMP signaling pathway_Homo sapiens_hsa040240.71604706
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71415927
104Renal cell carcinoma_Homo sapiens_hsa052110.70841997
105Rap1 signaling pathway_Homo sapiens_hsa040150.70700759
106Prolactin signaling pathway_Homo sapiens_hsa049170.70386526
107Arginine and proline metabolism_Homo sapiens_hsa003300.70379937
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.70346935
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.68274002
110Gastric acid secretion_Homo sapiens_hsa049710.68206759
111Prion diseases_Homo sapiens_hsa050200.68069315
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67676476
113Estrogen signaling pathway_Homo sapiens_hsa049150.67426337
114Prostate cancer_Homo sapiens_hsa052150.66732075
115Oxytocin signaling pathway_Homo sapiens_hsa049210.66534050
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66005253
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64916294
118Notch signaling pathway_Homo sapiens_hsa043300.63930584
119Basal transcription factors_Homo sapiens_hsa030220.63373300
120Dorso-ventral axis formation_Homo sapiens_hsa043200.63098380
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.62662151
122Circadian entrainment_Homo sapiens_hsa047130.61111570
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.60785613
124Bile secretion_Homo sapiens_hsa049760.60726251
125GnRH signaling pathway_Homo sapiens_hsa049120.59831676
126Pancreatic secretion_Homo sapiens_hsa049720.59100017
127Glioma_Homo sapiens_hsa052140.57788768
128Endometrial cancer_Homo sapiens_hsa052130.57601322
129Caffeine metabolism_Homo sapiens_hsa002320.56988887
130Basal cell carcinoma_Homo sapiens_hsa052170.56987482
131Pyruvate metabolism_Homo sapiens_hsa006200.56976609
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55643709
133ErbB signaling pathway_Homo sapiens_hsa040120.54834396
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54570551
135Dopaminergic synapse_Homo sapiens_hsa047280.54028326
136Ras signaling pathway_Homo sapiens_hsa040140.53400642
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.53108306
138Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52263736
139Butanoate metabolism_Homo sapiens_hsa006500.52082968
140Chemical carcinogenesis_Homo sapiens_hsa052040.52056530
141Tyrosine metabolism_Homo sapiens_hsa003500.52039897
142Cholinergic synapse_Homo sapiens_hsa047250.51574006
143Glutamatergic synapse_Homo sapiens_hsa047240.50586786
144Amphetamine addiction_Homo sapiens_hsa050310.50371190
145Hedgehog signaling pathway_Homo sapiens_hsa043400.50189511
146Fructose and mannose metabolism_Homo sapiens_hsa000510.49590204
147Calcium signaling pathway_Homo sapiens_hsa040200.49130062
148AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49017104
149Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48878908
150Long-term depression_Homo sapiens_hsa047300.47443411
151Salivary secretion_Homo sapiens_hsa049700.46198304
152Choline metabolism in cancer_Homo sapiens_hsa052310.43629072

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