PTPN20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes. The encoded protein appears to be targeted to sites of actin polymerization. A pseudogene of this gene has been defined on chromosome 10. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis (GO:0007140)9.74789145
2binding of sperm to zona pellucida (GO:0007339)9.67202822
3acrosome reaction (GO:0007340)9.49539807
4motile cilium assembly (GO:0044458)9.26269101
5cilium movement (GO:0003341)9.22688120
6cell-cell recognition (GO:0009988)9.22222805
7plasma membrane fusion (GO:0045026)9.20491667
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.02797033
9synaptonemal complex organization (GO:0070193)9.02407267
10spermatid development (GO:0007286)8.74312103
11synaptonemal complex assembly (GO:0007130)8.65415268
12reproduction (GO:0000003)8.08847770
13DNA methylation involved in gamete generation (GO:0043046)7.80759567
14cell wall macromolecule catabolic process (GO:0016998)7.59148708
15cell wall macromolecule metabolic process (GO:0044036)7.59148708
16regulation of cilium movement (GO:0003352)7.58358271
17single fertilization (GO:0007338)6.95178729
18male meiosis I (GO:0007141)6.84160367
19sperm capacitation (GO:0048240)6.51727179
20chemosensory behavior (GO:0007635)6.30753005
21fertilization (GO:0009566)6.17005288
22chromosome organization involved in meiosis (GO:0070192)6.14277418
23ventricular system development (GO:0021591)5.85185270
24meiotic nuclear division (GO:0007126)5.80110144
25negative regulation of inclusion body assembly (GO:0090084)5.79369157
26spermatogenesis (GO:0007283)5.63257583
27male gamete generation (GO:0048232)5.61432527
28meiosis I (GO:0007127)5.55091250
29cellular ketone body metabolic process (GO:0046950)5.51262090
30meiotic cell cycle (GO:0051321)5.47924659
31germ cell development (GO:0007281)5.27031527
32protein localization to cilium (GO:0061512)5.20362831
33cellular process involved in reproduction in multicellular organism (GO:0022412)5.16186026
34gamete generation (GO:0007276)5.15604127
35positive regulation of glycolytic process (GO:0045821)5.10123884
36seminiferous tubule development (GO:0072520)5.09510954
37ketone body metabolic process (GO:1902224)4.83590050
38gene silencing by RNA (GO:0031047)4.76160358
39regulation of inclusion body assembly (GO:0090083)4.61834772
40regulation of type B pancreatic cell apoptotic process (GO:2000674)4.59471541
41regulation of microtubule-based movement (GO:0060632)4.53661870
42detection of light stimulus involved in sensory perception (GO:0050962)4.52933610
43detection of light stimulus involved in visual perception (GO:0050908)4.52933610
44organic cation transport (GO:0015695)4.50565077
45left/right pattern formation (GO:0060972)4.50539337
46cell recognition (GO:0008037)4.50513668
47microtubule severing (GO:0051013)4.49127765
48negative regulation of cytosolic calcium ion concentration (GO:0051481)4.47044366
49microtubule depolymerization (GO:0007019)4.35357264
50calcium ion-dependent exocytosis (GO:0017156)4.29109785
51intraciliary transport (GO:0042073)4.28802019
52genitalia morphogenesis (GO:0035112)4.22842717
53regulation of meiosis I (GO:0060631)4.12900370
54axoneme assembly (GO:0035082)4.11024225
55multicellular organismal reproductive process (GO:0048609)4.04023153
56negative regulation of organelle assembly (GO:1902116)3.95457595
57monoubiquitinated protein deubiquitination (GO:0035520)3.94850768
58regulation of energy homeostasis (GO:2000505)3.81526589
59establishment of protein localization to Golgi (GO:0072600)3.80986120
60microtubule-based movement (GO:0007018)3.78519484
61protein polyglutamylation (GO:0018095)3.73040980
62meiotic cell cycle process (GO:1903046)3.70766241
63embryonic retina morphogenesis in camera-type eye (GO:0060059)3.69878172
64negative regulation of gluconeogenesis (GO:0045721)3.65980453
65regulation of centriole replication (GO:0046599)3.65327393
66positive regulation of glycogen biosynthetic process (GO:0045725)3.62313203
67synapsis (GO:0007129)3.60308904
68protein targeting to Golgi (GO:0000042)3.56731089
69fatty acid homeostasis (GO:0055089)3.53150629
70regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.43014399
71chaperone-mediated protein complex assembly (GO:0051131)3.42091628
72regulation of hexokinase activity (GO:1903299)3.42056621
73regulation of glucokinase activity (GO:0033131)3.42056621
74regulation of protein polyubiquitination (GO:1902914)3.38400810
75coenzyme catabolic process (GO:0009109)3.35673472
76cilium organization (GO:0044782)3.32075108
77positive regulation of glycogen metabolic process (GO:0070875)3.31896799
78insulin secretion (GO:0030073)3.29804263
79negative regulation of DNA repair (GO:0045738)3.29147848
80regulation of protein glycosylation (GO:0060049)3.28873190
81carnitine transmembrane transport (GO:1902603)3.28087920
82multicellular organismal development (GO:0007275)3.26062460
83nucleoside diphosphate phosphorylation (GO:0006165)3.25099893
84retrograde transport, vesicle recycling within Golgi (GO:0000301)3.23849815
85carnitine transport (GO:0015879)3.23672805
86amino-acid betaine transport (GO:0015838)3.23672805
87negative regulation of protein oligomerization (GO:0032460)3.21953302
88nuclear pore complex assembly (GO:0051292)3.21764686
89lactate metabolic process (GO:0006089)3.21672765
90dendritic spine morphogenesis (GO:0060997)3.19709403
91calcium ion import (GO:0070509)3.19490513
92alditol metabolic process (GO:0019400)3.16285220
93endocrine pancreas development (GO:0031018)3.13452008
94cilium assembly (GO:0042384)3.12188044
95gene silencing (GO:0016458)3.09612339
96centriole replication (GO:0007099)3.09556468
97spermatid nucleus differentiation (GO:0007289)3.03712230
98retinal cone cell development (GO:0046549)3.03015797
99photoreceptor cell maintenance (GO:0045494)3.01245403
100cilium morphogenesis (GO:0060271)2.99533520
101cellular component assembly involved in morphogenesis (GO:0010927)2.96733807
102DNA alkylation (GO:0006305)2.96277726
103DNA methylation (GO:0006306)2.96277726
104detection of calcium ion (GO:0005513)2.94000710
105signal peptide processing (GO:0006465)2.93942048
106positive regulation of meiosis (GO:0045836)2.93442446
107inositol phosphate catabolic process (GO:0071545)2.91892621
108proline transport (GO:0015824)2.90795044
109nitric oxide mediated signal transduction (GO:0007263)2.89524916
110primary amino compound metabolic process (GO:1901160)2.88852117
111glycerol metabolic process (GO:0006071)2.88447160
112neurofilament cytoskeleton organization (GO:0060052)2.88038730
113regulation of spindle checkpoint (GO:0090231)2.87695351
114protein refolding (GO:0042026)2.87433111
115membrane depolarization during action potential (GO:0086010)2.87318877
116positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.85224378
117mitotic sister chromatid cohesion (GO:0007064)2.84708499
118positive regulation of insulin secretion (GO:0032024)2.83721002
119centriole assembly (GO:0098534)2.83439897
120protein localization to Golgi apparatus (GO:0034067)2.79675511
121polyol catabolic process (GO:0046174)2.77104128
122glycerol ether metabolic process (GO:0006662)2.77031428
123regulation of histone H3-K9 methylation (GO:0051570)2.76550492
124regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.76545135
125GTP biosynthetic process (GO:0006183)2.76218456
126male sex determination (GO:0030238)2.74896155
127positive regulation of meiotic cell cycle (GO:0051446)2.74136169
128DNA packaging (GO:0006323)2.73065836
129sex differentiation (GO:0007548)2.72986098
130positive regulation of peptide hormone secretion (GO:0090277)2.72367751
131positive regulation of glucose metabolic process (GO:0010907)2.72094355
132peptidyl-glutamic acid modification (GO:0018200)2.71758459
133neuronal action potential (GO:0019228)2.71666455
134indolalkylamine metabolic process (GO:0006586)2.71304514
135carnitine shuttle (GO:0006853)2.70301217
136positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.70222647
137translesion synthesis (GO:0019985)2.69740255
138alanine transport (GO:0032328)2.68229440
139urinary tract smooth muscle contraction (GO:0014848)2.67502350
140Golgi to endosome transport (GO:0006895)2.66488711
141positive regulation of cellular carbohydrate metabolic process (GO:0010676)2.65917343
142fatty acid transmembrane transport (GO:1902001)2.65301391
143cyclic nucleotide catabolic process (GO:0009214)2.65184344
144regulation of chromatin binding (GO:0035561)2.65176614
145left/right axis specification (GO:0070986)2.64174604
146chromosome condensation (GO:0030261)2.64091868
147positive regulation of peptide secretion (GO:0002793)2.62271131
148regulation of acrosome reaction (GO:0060046)2.60805564
149sister chromatid cohesion (GO:0007062)2.60465172
150regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.57870275
151regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.57418913
152xenobiotic catabolic process (GO:0042178)2.49167375
153negative regulation of dendrite morphogenesis (GO:0050774)2.48500280
154cAMP catabolic process (GO:0006198)2.47879259
155phosphorylated carbohydrate dephosphorylation (GO:0046838)2.47487745
156inositol phosphate dephosphorylation (GO:0046855)2.47487745
157negative regulation of cAMP-mediated signaling (GO:0043951)2.47222358
158relaxation of cardiac muscle (GO:0055119)2.47128048
159spinal cord motor neuron differentiation (GO:0021522)2.46235361
160membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.45912563
161positive regulation of carbohydrate metabolic process (GO:0045913)2.45106544
162regulation of glycolytic process (GO:0006110)2.44779633
163phosphatidylethanolamine biosynthetic process (GO:0006646)2.41999765
164righting reflex (GO:0060013)2.40155088
165serotonin metabolic process (GO:0042428)2.38417665
166regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.37867244
167histone H2A acetylation (GO:0043968)2.34802026
168synaptic vesicle docking involved in exocytosis (GO:0016081)2.34724402
169auditory receptor cell stereocilium organization (GO:0060088)2.33523663
170indolalkylamine catabolic process (GO:0046218)2.32599038
171cilium or flagellum-dependent cell motility (GO:0001539)17.8872714
172piRNA metabolic process (GO:0034587)12.6821582
173fusion of sperm to egg plasma membrane (GO:0007342)12.0867674
174axonemal dynein complex assembly (GO:0070286)11.3946606
175sperm motility (GO:0030317)11.2465548
176sperm-egg recognition (GO:0035036)10.3310907
177acrosome assembly (GO:0001675)10.1900255
178epithelial cilium movement (GO:0003351)10.0305406
179multicellular organism reproduction (GO:0032504)10.0282816

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.66404123
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.58405723
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.56872310
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.53179220
5GBX2_23144817_ChIP-Seq_PC3_Human3.35873258
6IGF1R_20145208_ChIP-Seq_DFB_Human2.54682903
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.49201137
8TAF15_26573619_Chip-Seq_HEK293_Human2.40870133
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32404383
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.28885682
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.28848159
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.21451621
13ZNF274_21170338_ChIP-Seq_K562_Hela2.13122610
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12285826
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11946130
16CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.09507005
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07471799
18GATA1_26923725_Chip-Seq_HPCs_Mouse2.06375176
19SMAD4_21799915_ChIP-Seq_A2780_Human2.03875705
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.03186527
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03100277
22PCGF2_27294783_Chip-Seq_ESCs_Mouse2.02753074
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.00666410
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.8647560
25FUS_26573619_Chip-Seq_HEK293_Human1.96422925
26P300_19829295_ChIP-Seq_ESCs_Human1.91334419
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.90042130
28STAT3_23295773_ChIP-Seq_U87_Human1.89175628
29VDR_22108803_ChIP-Seq_LS180_Human1.77854992
30AR_25329375_ChIP-Seq_VCAP_Human1.72091022
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69993220
32SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.67932619
33* ELK4_26923725_Chip-Seq_MESODERM_Mouse1.62593095
34SMAD3_21741376_ChIP-Seq_EPCs_Human1.62416433
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59773588
36TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53889453
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53524570
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52499850
39NFE2_27457419_Chip-Seq_LIVER_Mouse1.49715088
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48615624
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46234676
42WDR5_24793694_ChIP-Seq_LNCAP_Human1.45988196
43STAT1_17558387_ChIP-Seq_HELA_Human1.44126296
44* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.42195583
45KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.42070907
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.40376141
47TAL1_26923725_Chip-Seq_HPCs_Mouse1.39541247
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39007902
49RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.38195155
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37697705
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37386070
52CBP_20019798_ChIP-Seq_JUKART_Human1.37386070
53KAP1_22055183_ChIP-Seq_ESCs_Mouse1.37351050
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36679178
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35984755
56RUNX2_22187159_ChIP-Seq_PCA_Human1.35376447
57ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34742971
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34738982
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.34287433
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.34016751
61AHR_22903824_ChIP-Seq_MCF-7_Human1.31943865
62GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.31461182
63SOX2_19829295_ChIP-Seq_ESCs_Human1.30910570
64NANOG_19829295_ChIP-Seq_ESCs_Human1.30910570
65FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29947608
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29022113
67* REST_21632747_ChIP-Seq_MESCs_Mouse1.28753710
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26934386
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23914118
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23243511
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.22650123
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.22128119
73MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21734136
74SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21671875
75TCF4_22108803_ChIP-Seq_LS180_Human1.21578616
76KDM2B_26808549_Chip-Seq_REH_Human1.21319241
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20647619
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20647619
79SOX2_22085726_ChIP-Seq_NPCs_Mouse1.20079513
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19760410
81SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.19081814
82AR_21572438_ChIP-Seq_LNCaP_Human1.18836883
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17936112
84EWS_26573619_Chip-Seq_HEK293_Human1.17161466
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.17152856
86HTT_18923047_ChIP-ChIP_STHdh_Human1.16183298
87GATA3_21867929_ChIP-Seq_CD8_Mouse1.15350327
88ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14268955
89TBL1_22424771_ChIP-Seq_293T_Human1.12889064
90SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12542530
91FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12418173
92DROSHA_22980978_ChIP-Seq_HELA_Human1.11506204
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11269822
94FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11263876
95CRX_20693478_ChIP-Seq_RETINA_Mouse1.10046159
96TP53_22573176_ChIP-Seq_HFKS_Human1.09603911
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.08656430
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08595052
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08286430
100CDX2_22108803_ChIP-Seq_LS180_Human1.07467243
101OCT4_18555785_Chip-Seq_ESCs_Mouse1.06451419
102LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.04784382
103E2F1_18555785_Chip-Seq_ESCs_Mouse1.04765782
104SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04394428
105BCAT_22108803_ChIP-Seq_LS180_Human1.04222281
106MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02322948
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.02105604
108EZH2_27294783_Chip-Seq_NPCs_Mouse1.01827944
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01569324
110NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01019227
111EP300_21415370_ChIP-Seq_HL-1_Mouse1.00886625
112P53_21459846_ChIP-Seq_SAOS-2_Human1.00774484
113ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00699546
114GATA3_21867929_ChIP-Seq_TH1_Mouse1.00694983
115NFYB_21822215_ChIP-Seq_K562_Human1.00650441
116CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00578052
117* RNF2_27304074_Chip-Seq_NSC_Mouse1.00189292
118RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00144420
119TCF4_23295773_ChIP-Seq_U87_Human0.98219776
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97599196
121P53_22387025_ChIP-Seq_ESCs_Mouse0.97137293
122CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97119223
123FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97034956
124P300_18555785_Chip-Seq_ESCs_Mouse0.96688584
125PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96656725
126OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96636124
127KLF4_18555785_Chip-Seq_ESCs_Mouse0.95320019
128STAT3_18555785_Chip-Seq_ESCs_Mouse0.94483224
129RUNX1_26923725_Chip-Seq_HPCs_Mouse0.93985864
130TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93104636
131EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92412398
132GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92332699
133PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92059465
134ESRRB_18555785_Chip-Seq_ESCs_Mouse0.91106656
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90808703
136ER_23166858_ChIP-Seq_MCF-7_Human0.90702343
137ERG_20517297_ChIP-Seq_VCAP_Human0.88481774
138* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88469298
139YY1_22570637_ChIP-Seq_MALME-3M_Human0.88016185
140* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87771233
141SOX2_21211035_ChIP-Seq_LN229_Human0.87449926
142* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87217492
143* GF1_26923725_Chip-Seq_HPCs_Mouse0.86900710
144EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86102985
145CMYC_18555785_Chip-Seq_ESCs_Mouse0.86098766
146SMAD4_21741376_ChIP-Seq_EPCs_Human0.85799282
147RUNX1_27457419_Chip-Seq_LIVER_Mouse0.84646734
148RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84554560
149PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84067172
150SUZ12_18555785_Chip-Seq_ESCs_Mouse0.84006159
151PU1_27457419_Chip-Seq_LIVER_Mouse0.83142617
152PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82470613
153ESET_19884257_ChIP-Seq_ESCs_Mouse0.82422509
154FOXA1_27270436_Chip-Seq_PROSTATE_Human0.81973772
155FOXA1_25329375_ChIP-Seq_VCAP_Human0.81973772
156MYC_27129775_Chip-Seq_CORNEA_Mouse0.80490619

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.97671048
2MP0003698_abnormal_male_reproductive5.91940232
3MP0001929_abnormal_gametogenesis5.52117566
4MP0002210_abnormal_sex_determination4.08828379
5MP0003195_calcinosis4.03666180
6MP0002653_abnormal_ependyma_morphology3.88920116
7MP0001145_abnormal_male_reproductive3.40807539
8MP0002837_dystrophic_cardiac_calcinosis3.29061259
9MP0002161_abnormal_fertility/fecundity3.18678298
10MP0009780_abnormal_chondrocyte_physiolo3.03627673
11MP0000653_abnormal_sex_gland2.95624963
12MP0010234_abnormal_vibrissa_follicle2.77629242
13MP0005623_abnormal_meninges_morphology2.63268950
14MP0008057_abnormal_DNA_replication2.47527210
15MP0002160_abnormal_reproductive_system2.25083074
16MP0002735_abnormal_chemical_nociception2.06070990
17MP0009745_abnormal_behavioral_response2.04058958
18MP0001501_abnormal_sleep_pattern2.03531068
19MP0005410_abnormal_fertilization14.3551291
20MP0001944_abnormal_pancreas_morphology1.89256720
21MP0004215_abnormal_myocardial_fiber1.82594673
22MP0002693_abnormal_pancreas_physiology1.81790317
23MP0004859_abnormal_synaptic_plasticity1.68135840
24MP0010386_abnormal_urinary_bladder1.66267097
25MP0003283_abnormal_digestive_organ1.63397223
26MP0005379_endocrine/exocrine_gland_phen1.63134646
27MP0002064_seizures1.54273035
28MP0009046_muscle_twitch1.54211384
29MP0001756_abnormal_urination1.52680877
30MP0001968_abnormal_touch/_nociception1.49539322
31MP0005386_behavior/neurological_phenoty1.47719270
32MP0004924_abnormal_behavior1.47719270
33MP0003646_muscle_fatigue1.47688811
34MP0001486_abnormal_startle_reflex1.46865876
35MP0010094_abnormal_chromosome_stability1.46846262
36MP0002282_abnormal_trachea_morphology1.41805981
37MP0002909_abnormal_adrenal_gland1.41498955
38MP0008058_abnormal_DNA_repair1.41185567
39MP0003635_abnormal_synaptic_transmissio1.39798264
40MP0006276_abnormal_autonomic_nervous1.39322414
41MP0002163_abnormal_gland_morphology1.36739808
42MP0010678_abnormal_skin_adnexa1.36422267
43MP0000013_abnormal_adipose_tissue1.36236925
44MP0003787_abnormal_imprinting1.34614037
45MP0002078_abnormal_glucose_homeostasis1.30996175
46MP0002638_abnormal_pupillary_reflex1.30013259
47MP0005645_abnormal_hypothalamus_physiol1.29222188
48MP0003011_delayed_dark_adaptation1.26542147
49MP0004085_abnormal_heartbeat1.23300227
50MP0002090_abnormal_vision1.22516031
51MP0002557_abnormal_social/conspecific_i1.22105490
52MP0010368_abnormal_lymphatic_system1.21419095
53MP0008995_early_reproductive_senescence1.20457331
54MP0001970_abnormal_pain_threshold1.17145247
55MP0005647_abnormal_sex_gland1.15553432
56MP0005670_abnormal_white_adipose1.15106876
57MP0010329_abnormal_lipoprotein_level1.14080855
58MP0001485_abnormal_pinna_reflex1.12863387
59MP0004510_myositis1.12293571
60MP0002067_abnormal_sensory_capabilities1.11566399
61MP0005389_reproductive_system_phenotype1.10842331
62MP0000631_abnormal_neuroendocrine_gland1.08424397
63MP0003953_abnormal_hormone_level1.07737001
64MP0001984_abnormal_olfaction1.06600104
65MP0008872_abnormal_physiological_respon1.05627300
66MP0003786_premature_aging1.03205645
67MP0000538_abnormal_urinary_bladder1.01603651
68MP0005448_abnormal_energy_balance1.00402050
69MP0008007_abnormal_cellular_replicative0.99852431
70MP0002063_abnormal_learning/memory/cond0.98767795
71MP0004084_abnormal_cardiac_muscle0.98111745
72MP0000383_abnormal_hair_follicle0.97878921
73MP0005220_abnormal_exocrine_pancreas0.96757810
74MP0004233_abnormal_muscle_weight0.95443635
75MP0000569_abnormal_digit_pigmentation0.95234939
76MP0003880_abnormal_central_pattern0.91083941
77MP0000003_abnormal_adipose_tissue0.90558066
78MP0001529_abnormal_vocalization0.88787405
79MP0002876_abnormal_thyroid_physiology0.88597127
80MP0005332_abnormal_amino_acid0.87379670
81MP0001765_abnormal_ion_homeostasis0.85440226
82MP0002138_abnormal_hepatobiliary_system0.84832779
83MP0005266_abnormal_metabolism0.84400490
84MP0005535_abnormal_body_temperature0.83847683
85MP0004145_abnormal_muscle_electrophysio0.82990673
86MP0003122_maternal_imprinting0.81760217
87MP0000358_abnormal_cell_content/0.81203771
88MP0002734_abnormal_mechanical_nocicepti0.80509803
89MP0003950_abnormal_plasma_membrane0.74898060
90MP0004134_abnormal_chest_morphology0.72407080
91MP0003111_abnormal_nucleus_morphology0.71468256
92MP0003329_amyloid_beta_deposits0.68071733
93MP0004808_abnormal_hematopoietic_stem0.64364140
94MP0003878_abnormal_ear_physiology0.59745432
95MP0005377_hearing/vestibular/ear_phenot0.59745432
96MP0001545_abnormal_hematopoietic_system0.58183048
97MP0005397_hematopoietic_system_phenotyp0.58183048
98MP0010307_abnormal_tumor_latency0.53677537
99MP0009278_abnormal_bone_marrow0.52559964
100MP0005551_abnormal_eye_electrophysiolog0.51898689
101MP0005253_abnormal_eye_physiology0.49960695
102MP0003115_abnormal_respiratory_system0.49250242
103MP0003699_abnormal_female_reproductive0.48706163
104MP0002234_abnormal_pharynx_morphology0.48039884
105MP0001119_abnormal_female_reproductive0.47800948
106MP0001293_anophthalmia0.44965582
107MP0001730_embryonic_growth_arrest0.41765336
108MP0001661_extended_life_span0.40356860
109MP0000427_abnormal_hair_cycle0.40331213
110MP0005391_vision/eye_phenotype0.40046906
111MP0005636_abnormal_mineral_homeostasis0.39869787
112MP0002928_abnormal_bile_duct0.39191212
113MP0002152_abnormal_brain_morphology0.37590233
114MP0003077_abnormal_cell_cycle0.37237367
115MP0004133_heterotaxia0.36664473
116MP0001440_abnormal_grooming_behavior0.36380647
117MP0003861_abnormal_nervous_system0.36318508
118MP0000604_amyloidosis0.35712735
119MP0005423_abnormal_somatic_nervous0.35554797
120MP0001727_abnormal_embryo_implantation0.35304265
121MP0001986_abnormal_taste_sensitivity0.34263756
122MP0003879_abnormal_hair_cell0.33084339
123MP0004036_abnormal_muscle_relaxation0.31574906
124MP0004811_abnormal_neuron_physiology0.29510779
125MP0002084_abnormal_developmental_patter0.29449550
126MP0000313_abnormal_cell_death0.28634669
127MP0001324_abnormal_eye_pigmentation0.28254384
128MP0006036_abnormal_mitochondrial_physio0.27988593
129MP0002971_abnormal_brown_adipose0.27962050
130MP0004019_abnormal_vitamin_homeostasis0.27237339
131MP0006035_abnormal_mitochondrial_morpho0.26699010
132MP0002269_muscular_atrophy0.26088764
133MP0000751_myopathy0.25535828
134MP0002092_abnormal_eye_morphology0.25529112
135MP0006072_abnormal_retinal_apoptosis0.25420756
136MP0003631_nervous_system_phenotype0.25058073
137MP0001851_eye_inflammation0.24876711
138MP0002572_abnormal_emotion/affect_behav0.24493152
139MP0000015_abnormal_ear_pigmentation0.24054814
140MP0003045_fibrosis0.24045025
141MP0002229_neurodegeneration0.23988635
142MP0003633_abnormal_nervous_system0.23772879
143MP0002102_abnormal_ear_morphology0.23068568
144MP0002108_abnormal_muscle_morphology0.22108329
145MP0004742_abnormal_vestibular_system0.22033713
146MP0000955_abnormal_spinal_cord0.21474569
147MP0003936_abnormal_reproductive_system0.20379090
148MP0005646_abnormal_pituitary_gland0.20094534
149MP0001764_abnormal_homeostasis0.20091079
150MP0004270_analgesia0.19891031
151MP0002272_abnormal_nervous_system0.19341270
152MP0005666_abnormal_adipose_tissue0.18624396
153MP0003634_abnormal_glial_cell0.18350405
154MP0005174_abnormal_tail_pigmentation0.18304103
155MP0004043_abnormal_pH_regulation0.18213728
156MP0000647_abnormal_sebaceous_gland0.17808255
157MP0008932_abnormal_embryonic_tissue0.17663482
158MP0003632_abnormal_nervous_system0.17278367
159MP0001697_abnormal_embryo_size0.17044902

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.64822038
2Abnormal respiratory motile cilium morphology (HP:0005938)8.77571611
3Abnormal respiratory epithelium morphology (HP:0012253)8.77571611
4Rhinitis (HP:0012384)8.33676294
5Abnormal ciliary motility (HP:0012262)7.87459453
6Chronic bronchitis (HP:0004469)7.15066347
7Nasal polyposis (HP:0100582)6.39488820
8Infertility (HP:0000789)6.22454873
9Abnormality of the nasal mucosa (HP:0000433)5.22596495
10Bronchiectasis (HP:0002110)4.85125110
11Nephronophthisis (HP:0000090)4.60414642
12Bronchitis (HP:0012387)4.43714554
13Hypothermia (HP:0002045)4.42681604
14Ketoacidosis (HP:0001993)4.17800247
15Abnormality of the lower motor neuron (HP:0002366)4.12852474
16Hyperglycemia (HP:0003074)3.84475039
17Calf muscle hypertrophy (HP:0008981)3.82215824
18Hypoglycemic seizures (HP:0002173)3.80291510
19Hyperinsulinemic hypoglycemia (HP:0000825)3.73789416
20Hypoglycemic coma (HP:0001325)3.57697934
21Muscle hypertrophy of the lower extremities (HP:0008968)3.56855281
22Abnormality of the renal medulla (HP:0100957)3.54079962
23Gonadotropin excess (HP:0000837)3.42998909
24Febrile seizures (HP:0002373)3.39919386
25Retinal atrophy (HP:0001105)3.36543969
26Recurrent otitis media (HP:0000403)3.33407714
27Intestinal atresia (HP:0011100)3.26653738
28Amyotrophic lateral sclerosis (HP:0007354)3.25741678
29Recurrent sinusitis (HP:0011108)3.23678602
30Large for gestational age (HP:0001520)3.16266456
31Abnormality of the pancreatic islet cells (HP:0006476)3.07656899
32Abnormality of endocrine pancreas physiology (HP:0012093)3.07656899
33Tubulointerstitial nephritis (HP:0001970)3.05796070
34Hyperventilation (HP:0002883)3.00655395
35Congenital stationary night blindness (HP:0007642)2.99727460
36Attenuation of retinal blood vessels (HP:0007843)2.95377333
37Insulin-resistant diabetes mellitus (HP:0000831)2.94380942
38Focal motor seizures (HP:0011153)2.87800917
39Fibular hypoplasia (HP:0003038)2.82482395
40Severe visual impairment (HP:0001141)2.76574372
41Ketosis (HP:0001946)2.74948826
42Increased circulating renin level (HP:0000848)2.72015187
43Hypomagnesemia (HP:0002917)2.70301111
44Sex reversal (HP:0012245)2.68814350
45Abnormal sex determination (HP:0012244)2.68814350
46Bony spicule pigmentary retinopathy (HP:0007737)2.68632083
47Male infertility (HP:0003251)2.65971445
48Epileptiform EEG discharges (HP:0011182)2.65075390
49Abnormal spermatogenesis (HP:0008669)2.64296142
50EEG with generalized epileptiform discharges (HP:0011198)2.64204475
51Recurrent bronchitis (HP:0002837)2.62813359
52Absence seizures (HP:0002121)2.62163952
53Syncope (HP:0001279)2.61886208
54Dialeptic seizures (HP:0011146)2.61512231
55Focal seizures (HP:0007359)2.58702682
56Late onset (HP:0003584)2.58576126
57Hemiparesis (HP:0001269)2.56898108
58Medial flaring of the eyebrow (HP:0010747)2.54683197
59Molar tooth sign on MRI (HP:0002419)2.52548649
60Abnormality of midbrain morphology (HP:0002418)2.52548649
61Abnormality of the calf musculature (HP:0001430)2.51212522
62Hypsarrhythmia (HP:0002521)2.51140084
63Impaired proprioception (HP:0010831)2.47755081
64Abnormal rod and cone electroretinograms (HP:0008323)2.45630642
65Tubulointerstitial abnormality (HP:0001969)2.45045908
66Tubular atrophy (HP:0000092)2.44426086
67Testicular neoplasm (HP:0010788)2.38761143
68Atonic seizures (HP:0010819)2.37794829
69Upper motor neuron abnormality (HP:0002127)2.36613737
70Prominent metopic ridge (HP:0005487)2.35685882
71Abnormality of macular pigmentation (HP:0008002)2.33214448
72Polyuria (HP:0000103)2.30436854
73Impulsivity (HP:0100710)2.30392230
74Increased density of long bones (HP:0006392)2.29815246
75Postaxial foot polydactyly (HP:0001830)2.28023758
76Hypoplasia of the capital femoral epiphysis (HP:0003090)2.27387560
77Azoospermia (HP:0000027)2.26850130
78Aplasia/Hypoplasia of the fovea (HP:0008060)2.21063458
79Hypoplasia of the fovea (HP:0007750)2.21063458
80Abnormality of the anterior horn cell (HP:0006802)2.20988806
81Degeneration of anterior horn cells (HP:0002398)2.20988806
82Symptomatic seizures (HP:0011145)2.19664631
83Abnormality of the metopic suture (HP:0005556)2.19131208
84Congenital sensorineural hearing impairment (HP:0008527)2.18983905
85Microglossia (HP:0000171)2.18877465
86Renal salt wasting (HP:0000127)2.17952614
87Progressive cerebellar ataxia (HP:0002073)2.10185392
88Absent frontal sinuses (HP:0002688)2.07978604
89Stage 5 chronic kidney disease (HP:0003774)2.06692499
90Difficulty running (HP:0009046)2.01056507
91Epileptic encephalopathy (HP:0200134)2.00613204
92J-shaped sella turcica (HP:0002680)2.00319360
93Hyperkalemia (HP:0002153)2.00274009
94Prolonged QT interval (HP:0001657)2.00206444
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.7891441
96Dynein arm defect of respiratory motile cilia (HP:0012255)12.0936719
97Absent/shortened dynein arms (HP:0200106)12.0936719
98Pancreatic cysts (HP:0001737)1.99032255
99Abnormal urine output (HP:0012590)1.97566449
100Atrial fibrillation (HP:0005110)1.96761083
101Abnormal pancreas size (HP:0012094)1.96372072
102Shoulder girdle muscle weakness (HP:0003547)1.96303754
103Congenital hepatic fibrosis (HP:0002612)1.96086285
104Chronic hepatic failure (HP:0100626)1.95595343
105Enlarged penis (HP:0000040)1.95344468
106Albinism (HP:0001022)1.93832637
107Tongue fasciculations (HP:0001308)1.92179770
108Short ribs (HP:0000773)1.92162545
109Male pseudohermaphroditism (HP:0000037)1.92137636
110Supernumerary spleens (HP:0009799)1.91812106
111Type I diabetes mellitus (HP:0100651)1.90959323
112Prolonged partial thromboplastin time (HP:0003645)1.90660063
113Pigmentary retinal degeneration (HP:0001146)1.88506115
114True hermaphroditism (HP:0010459)1.87742151
115Sudden death (HP:0001699)1.86867050
116Chronic sinusitis (HP:0011109)1.86439985
117Vascular calcification (HP:0004934)1.86423315
118Genital tract atresia (HP:0001827)1.85927636
119Spastic tetraparesis (HP:0001285)1.85789996
120Tubulointerstitial fibrosis (HP:0005576)1.83755168
12111 pairs of ribs (HP:0000878)1.82890365
122Oculomotor apraxia (HP:0000657)1.82608658
123Progressive inability to walk (HP:0002505)1.82470218
124Abnormality of the renal cortex (HP:0011035)1.82274707
125Abnormality of magnesium homeostasis (HP:0004921)1.82075047
126Abnormality of dentin (HP:0010299)1.81655649
127Stridor (HP:0010307)1.80161528
128Absent epiphyses (HP:0010577)1.79143404
129Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.79143404
130EMG: myopathic abnormalities (HP:0003458)1.78364787
131Renal dysplasia (HP:0000110)1.78259018
132Facial cleft (HP:0002006)1.78221112
133Broad-based gait (HP:0002136)1.77715990
134Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.74948597
135Aplasia/Hypoplasia of the fibula (HP:0006492)1.73917927
136Abnormality of potassium homeostasis (HP:0011042)1.73042284
137Abnormality of permanent molar morphology (HP:0011071)1.72972972
138Abnormality of the dental root (HP:0006486)1.72972972
139Taurodontia (HP:0000679)1.72972972
140Primary atrial arrhythmia (HP:0001692)1.72914261
141Vaginal atresia (HP:0000148)1.72801968
142Poor coordination (HP:0002370)1.72673411
143Ulnar claw (HP:0001178)1.72643258
144Abnormal albumin level (HP:0012116)1.72512523
145Hypoalbuminemia (HP:0003073)1.72512523
146Horizontal nystagmus (HP:0000666)1.72076417
147Postaxial hand polydactyly (HP:0001162)1.70333375
148Median cleft lip (HP:0000161)1.68993663
149Abnormal drinking behavior (HP:0030082)1.66633422
150Polydipsia (HP:0001959)1.66633422
151Heterotopia (HP:0002282)1.63486851
152Abnormal gallbladder physiology (HP:0012438)1.62199238
153Cholecystitis (HP:0001082)1.62199238
154Abnormality of molar (HP:0011077)1.61762189
155Abnormality of molar morphology (HP:0011070)1.61762189
156Short thorax (HP:0010306)1.59434856
157Abnormality of the dental pulp (HP:0006479)1.56035967
158Breast carcinoma (HP:0003002)1.53653506
159Aplasia/Hypoplasia of the tongue (HP:0010295)1.53177363
160Conjunctival telangiectasia (HP:0000524)1.50602934
161Bell-shaped thorax (HP:0001591)1.49067033
162Gait imbalance (HP:0002141)1.48847310
163Congenital primary aphakia (HP:0007707)1.48192772
164Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.46586219
165Deformed sella turcica (HP:0002681)1.42854057
166Selective tooth agenesis (HP:0001592)1.40038937
167Gaze-evoked nystagmus (HP:0000640)1.39106281
168Pachygyria (HP:0001302)1.37783622
169Abnormality of renal excretion (HP:0011036)1.37417909
170Nephropathy (HP:0000112)1.36967256
171Decreased motor nerve conduction velocity (HP:0003431)1.35855133
172Cystic liver disease (HP:0006706)1.33472229
173Broad distal phalanx of finger (HP:0009836)1.33131971
174Large eyes (HP:0001090)1.32918673
175Abnormality of ocular smooth pursuit (HP:0000617)1.30955031
176Pancreatic fibrosis (HP:0100732)1.29636246
177Atrophy/Degeneration involving motor neurons (HP:0007373)1.28958923
178Bile duct proliferation (HP:0001408)1.28167581
179Abnormal biliary tract physiology (HP:0012439)1.28167581
180Nephrogenic diabetes insipidus (HP:0009806)1.26520485
181Short femoral neck (HP:0100864)1.25909822
182Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.22977819
183Hypoplasia of dental enamel (HP:0006297)1.21256283
184Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.21189204

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.15106853
2PDK38.91730967
3PDK48.91730967
4PDK25.75626350
5TESK14.40186893
6PRKD33.48169582
7PNCK3.08840202
8ICK3.02683570
9MAP4K22.97455523
10WNK42.66305400
11STK392.62317465
12FGFR22.61874161
13PTK2B2.48291450
14INSRR2.34278556
15CASK2.32122107
16MST42.10130434
17ADRBK22.08849909
18NEK22.04558817
19STK162.01528852
20MAP3K21.92743197
21MAP3K71.91135974
22PAK31.72885933
23OBSCN1.68776878
24PHKG11.65358037
25PHKG21.65358037
26TRPM71.63944540
27NLK1.60213269
28DAPK21.49506621
29MAPK151.48241597
30FGFR31.47658272
31PLK21.35560124
32STK381.33789450
33ACVR1B1.33395415
34WNK11.29051471
35FER1.25398514
36CDC71.21063579
37MAPK131.16749301
38GRK11.11806316
39SGK21.08272191
40CCNB11.06711546
41CSNK1G11.03649935
42PIK3CG1.03593322
43PRKCE1.02203989
44STK31.00231549
45BMPR1B0.94331723
46PRKAA20.93977852
47PASK0.93567941
48OXSR10.92231832
49LATS10.92089525
50TYRO30.90235191
51WEE10.89630838
52DYRK1B0.77533203
53TTK0.76283567
54PDK10.76256544
55PINK10.76205151
56ADRBK10.76070407
57TNK20.75940599
58SGK4940.72982377
59SGK2230.72982377
60MYLK0.68487738
61ATR0.66975075
62NUAK10.65091079
63DDR20.64025444
64FLT30.64004160
65CAMK1G0.63774878
66DYRK30.59007578
67CHEK10.57905922
68ROCK10.56351642
69MAP3K120.56243836
70CAMK10.55303302
71SGK30.53634719
72CHEK20.53105337
73MAPK120.50359473
74CAMK2D0.50234649
75GRK70.50195909
76SGK10.49732804
77IRAK10.49404902
78NTRK20.48947601
79IRAK20.48596677
80CDK120.46497140
81CAMKK20.43708332
82PKN20.43583485
83CSNK1G20.43482533
84ATM0.43420015
85LMTK20.42693014
86TRIM280.42639643
87MAP2K10.41666928
88MAP3K40.39726618
89ZAK0.38531856
90PLK40.36621199
91EPHA30.36523349
92MET0.36432698
93PLK10.36279595
94CSNK1G30.35841620
95MTOR0.34974449
96WNK30.32749412
97ERBB30.31651339
98CSNK1A10.31572820
99CDK50.30912602
100GRK50.28943027
101CAMKK10.28671662
102DAPK10.28556279
103NEK90.28054907
104PRKCH0.27475526
105MUSK0.26191244
106EEF2K0.25631392
107MAP3K10.25320757
108PRKCG0.23991012
109CSNK1A1L0.23917261
110PAK20.23772019
111TNIK0.23625665
112PAK10.23059635
113TESK20.21645692
114PRKAA10.21055105
115PDPK10.20522528
116RPS6KB10.19863975
117MAP2K70.19132796
118MAPKAPK50.16265977
119RIPK40.15336172
120NME10.13672832
121PAK60.12814879
122MAP2K60.10481440
123CSNK1D0.10440923
124YES10.09787408
125CDK10.09771610
126MARK20.09612199
127STK38L0.09097958
128PRKDC0.07760685
129CDK20.07414372
130NEK60.07284674
131PRKACB0.06962042
132BRAF0.06555604
133CDK30.06471672
134PRKG10.06178898
135STK110.06075053
136BRSK20.05659281
137GSK3B0.05482240
138CSNK2A10.05261991
139MAPK80.05198613
140EGFR0.04092964
141MARK10.03760871
142PRKACG0.03689997
143PRKCZ0.02889392
144MAPK100.02720929
145MARK30.01852040
146CDK150.01303027
147RPS6KA30.01293793
148RPS6KA10.01058244
149CAMK2A0.00970699
150PRKCQ0.00533733
151AURKA-0.0478914
152SRC-0.0396060
153PRKACA-0.0385740
154PRKCA-0.0378836
155MAPK1-0.0367612
156PBK-0.0359820
157CSF1R-0.0339905
158CSNK1E-0.0282187
159NTRK3-0.0256645
160CDK14-0.0214543
161CDK11A-0.0156434
162CDK18-0.0047316
163PDGFRB-0.0039561
164CSNK2A2-0.0022230
165PRKCB-0.0001698

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.08076163
2Vitamin B6 metabolism_Homo sapiens_hsa007504.91315087
3Pyruvate metabolism_Homo sapiens_hsa006204.27385882
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.76201056
5Dorso-ventral axis formation_Homo sapiens_hsa043203.63031149
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.33336505
7Propanoate metabolism_Homo sapiens_hsa006403.26582114
8Butanoate metabolism_Homo sapiens_hsa006503.12876677
9Fanconi anemia pathway_Homo sapiens_hsa034602.93988881
10Glucagon signaling pathway_Homo sapiens_hsa049222.81888183
11Basal transcription factors_Homo sapiens_hsa030222.81232642
12Huntingtons disease_Homo sapiens_hsa050162.76718393
13Selenocompound metabolism_Homo sapiens_hsa004502.70021499
14Fatty acid biosynthesis_Homo sapiens_hsa000612.50471953
15Pentose phosphate pathway_Homo sapiens_hsa000302.43407722
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.43267132
17Linoleic acid metabolism_Homo sapiens_hsa005912.31689519
18Oocyte meiosis_Homo sapiens_hsa041142.26659332
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.08984250
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03007314
21Phototransduction_Homo sapiens_hsa047441.89232325
22Glycerolipid metabolism_Homo sapiens_hsa005611.84006689
23Tryptophan metabolism_Homo sapiens_hsa003801.82565997
24Amphetamine addiction_Homo sapiens_hsa050311.77602544
25Circadian rhythm_Homo sapiens_hsa047101.71572817
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.64643731
27Type II diabetes mellitus_Homo sapiens_hsa049301.62564456
28Regulation of autophagy_Homo sapiens_hsa041401.62277539
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.58764410
30mRNA surveillance pathway_Homo sapiens_hsa030151.56257541
31RNA transport_Homo sapiens_hsa030131.53665576
32Morphine addiction_Homo sapiens_hsa050321.53486957
33GABAergic synapse_Homo sapiens_hsa047271.52246148
34Renin secretion_Homo sapiens_hsa049241.46981005
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.46654433
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44816553
37beta-Alanine metabolism_Homo sapiens_hsa004101.38508957
38Cardiac muscle contraction_Homo sapiens_hsa042601.38499471
39PPAR signaling pathway_Homo sapiens_hsa033201.33742302
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31363278
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.28281143
42Carbon metabolism_Homo sapiens_hsa012001.25611255
43Serotonergic synapse_Homo sapiens_hsa047261.25512936
44Glycerophospholipid metabolism_Homo sapiens_hsa005641.22528743
45Nitrogen metabolism_Homo sapiens_hsa009101.19863221
46Fructose and mannose metabolism_Homo sapiens_hsa000511.18833432
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.18029585
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17183952
49Ovarian steroidogenesis_Homo sapiens_hsa049131.16981044
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14598675
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14094123
52Ether lipid metabolism_Homo sapiens_hsa005651.12452503
53Long-term potentiation_Homo sapiens_hsa047201.10851829
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.10694664
55Antigen processing and presentation_Homo sapiens_hsa046121.09307884
56ABC transporters_Homo sapiens_hsa020101.06279986
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04316545
58Purine metabolism_Homo sapiens_hsa002301.00848408
59Protein export_Homo sapiens_hsa030600.98690812
60Fat digestion and absorption_Homo sapiens_hsa049750.98179076
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92253852
62Peroxisome_Homo sapiens_hsa041460.91001634
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89423943
64Histidine metabolism_Homo sapiens_hsa003400.88543231
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83730749
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83396706
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82915248
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82412839
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82123002
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.81440964
71Collecting duct acid secretion_Homo sapiens_hsa049660.80794873
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79928303
73Fatty acid metabolism_Homo sapiens_hsa012120.78423948
74Fatty acid elongation_Homo sapiens_hsa000620.77386063
75Biosynthesis of amino acids_Homo sapiens_hsa012300.76792365
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.75805473
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74339867
78Oxytocin signaling pathway_Homo sapiens_hsa049210.73475324
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72290108
80Calcium signaling pathway_Homo sapiens_hsa040200.71755590
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70431914
82Insulin resistance_Homo sapiens_hsa049310.70249514
83Homologous recombination_Homo sapiens_hsa034400.69722091
84Type I diabetes mellitus_Homo sapiens_hsa049400.69498254
85Estrogen signaling pathway_Homo sapiens_hsa049150.69342726
86N-Glycan biosynthesis_Homo sapiens_hsa005100.68023554
87mTOR signaling pathway_Homo sapiens_hsa041500.66622981
88Dilated cardiomyopathy_Homo sapiens_hsa054140.66193227
89Cocaine addiction_Homo sapiens_hsa050300.65694157
90Long-term depression_Homo sapiens_hsa047300.64317385
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63905865
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63133573
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.62145893
94Mineral absorption_Homo sapiens_hsa049780.59159840
95Starch and sucrose metabolism_Homo sapiens_hsa005000.58626375
96Retinol metabolism_Homo sapiens_hsa008300.57298841
97Cholinergic synapse_Homo sapiens_hsa047250.57201790
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57057122
99Fatty acid degradation_Homo sapiens_hsa000710.56543436
100Synaptic vesicle cycle_Homo sapiens_hsa047210.54945070
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54093524
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54066751
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53890666
104VEGF signaling pathway_Homo sapiens_hsa043700.53889146
105RNA degradation_Homo sapiens_hsa030180.53819493
106Taste transduction_Homo sapiens_hsa047420.52481498
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52438148
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51799375
109Sphingolipid metabolism_Homo sapiens_hsa006000.47589688
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46689088
111Glutathione metabolism_Homo sapiens_hsa004800.46020233
112Arginine and proline metabolism_Homo sapiens_hsa003300.45251842
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43994602
114Bile secretion_Homo sapiens_hsa049760.43918992
115Arginine biosynthesis_Homo sapiens_hsa002200.43573806
116Arachidonic acid metabolism_Homo sapiens_hsa005900.42567241
117Insulin secretion_Homo sapiens_hsa049110.40451734
118Alzheimers disease_Homo sapiens_hsa050100.40235938
119Inositol phosphate metabolism_Homo sapiens_hsa005620.40138649
120Endocytosis_Homo sapiens_hsa041440.40100223
121AMPK signaling pathway_Homo sapiens_hsa041520.39521280
122Circadian entrainment_Homo sapiens_hsa047130.38479406
123Systemic lupus erythematosus_Homo sapiens_hsa053220.38309217
124Chemical carcinogenesis_Homo sapiens_hsa052040.38164610
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37424575
126Metabolic pathways_Homo sapiens_hsa011000.36728942
127Pyrimidine metabolism_Homo sapiens_hsa002400.35853302
128Cell cycle_Homo sapiens_hsa041100.33918585
129Proteasome_Homo sapiens_hsa030500.33658035
130Hedgehog signaling pathway_Homo sapiens_hsa043400.33512139
131Glutamatergic synapse_Homo sapiens_hsa047240.33384298
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.31656654
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.29354139
134Legionellosis_Homo sapiens_hsa051340.27266441
135Oxidative phosphorylation_Homo sapiens_hsa001900.27136692
136Wnt signaling pathway_Homo sapiens_hsa043100.25958993
137Nicotine addiction_Homo sapiens_hsa050330.24697335
138Gastric acid secretion_Homo sapiens_hsa049710.23827745
139Olfactory transduction_Homo sapiens_hsa047400.22869772
140Thyroid hormone synthesis_Homo sapiens_hsa049180.22658658
141Alcoholism_Homo sapiens_hsa050340.21509540
142Dopaminergic synapse_Homo sapiens_hsa047280.19374987
143Pancreatic secretion_Homo sapiens_hsa049720.17584666
144Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.17138456
145Viral carcinogenesis_Homo sapiens_hsa052030.16268307
146Salivary secretion_Homo sapiens_hsa049700.16238184
147cAMP signaling pathway_Homo sapiens_hsa040240.15696019
148Parkinsons disease_Homo sapiens_hsa050120.15232258

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