PTPN18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.60387012
2neutrophil activation involved in immune response (GO:0002283)6.18366202
3viral transcription (GO:0019083)5.37041243
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.36420336
5negative regulation of cell killing (GO:0031342)5.15366563
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.15366563
7translational termination (GO:0006415)5.07639277
8DNA deamination (GO:0045006)4.96098073
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.92060157
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.92060157
11ribosomal small subunit biogenesis (GO:0042274)4.59881768
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.51926098
13positive regulation by symbiont of host defense response (GO:0052509)4.45598966
14modulation by symbiont of host defense response (GO:0052031)4.45598966
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.45598966
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.45598966
17positive regulation by organism of defense response of other organism involved in symbiotic interact4.45598966
18modulation by symbiont of host immune response (GO:0052553)4.45598966
19cotranslational protein targeting to membrane (GO:0006613)4.40481995
20antigen processing and presentation of endogenous antigen (GO:0019883)4.39596198
21protein targeting to ER (GO:0045047)4.38511921
22translational elongation (GO:0006414)4.31958441
23regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.30067406
24positive regulation of gamma-delta T cell activation (GO:0046645)4.22508275
25antigen processing and presentation via MHC class Ib (GO:0002475)4.22431435
26response to interferon-beta (GO:0035456)4.19146925
27protein localization to endoplasmic reticulum (GO:0070972)4.17700397
28detection of other organism (GO:0098543)4.16918910
29neutrophil activation (GO:0042119)4.15889277
30establishment of protein localization to endoplasmic reticulum (GO:0072599)4.15868538
31detection of bacterium (GO:0016045)4.14881253
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.05002050
33positive regulation of mast cell activation (GO:0033005)3.99389430
34viral life cycle (GO:0019058)3.92048628
35platelet dense granule organization (GO:0060155)3.91357468
36macrophage activation involved in immune response (GO:0002281)3.89069098
37regulation of B cell receptor signaling pathway (GO:0050855)3.81064988
38nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.80934366
39regulation of mast cell degranulation (GO:0043304)3.76468767
40cellular protein complex disassembly (GO:0043624)3.75602332
41granulocyte activation (GO:0036230)3.75438750
42definitive hemopoiesis (GO:0060216)3.69652673
43maturation of SSU-rRNA (GO:0030490)3.66983522
44leukocyte migration involved in inflammatory response (GO:0002523)3.64993349
45cellular extravasation (GO:0045123)3.60079478
46regulation of platelet aggregation (GO:0090330)3.58343043
47positive regulation of B cell differentiation (GO:0045579)3.51988494
48mast cell activation (GO:0045576)3.48027631
49defense response to protozoan (GO:0042832)3.46168477
50regulation of mast cell activation involved in immune response (GO:0033006)3.45869374
51myeloid cell activation involved in immune response (GO:0002275)3.45413359
52mature B cell differentiation involved in immune response (GO:0002313)3.44789513
53cellular response to interferon-beta (GO:0035458)3.41528513
54translational initiation (GO:0006413)3.41221454
55regulation of myeloid leukocyte mediated immunity (GO:0002886)3.39100634
56lymphoid progenitor cell differentiation (GO:0002320)3.38779745
57response to protozoan (GO:0001562)3.37331685
58detection of external biotic stimulus (GO:0098581)3.37105052
59regulation of mast cell activation (GO:0033003)3.34219273
60negative regulation of erythrocyte differentiation (GO:0045647)3.31239185
61microglial cell activation (GO:0001774)3.29477480
62protein complex disassembly (GO:0043241)3.27630001
63negative regulation of lymphocyte mediated immunity (GO:0002707)3.27073753
64negative regulation of interleukin-12 production (GO:0032695)3.27006701
65negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.26603330
66type I interferon signaling pathway (GO:0060337)3.25318045
67cellular response to type I interferon (GO:0071357)3.25318045
68regulation of leukocyte degranulation (GO:0043300)3.25139040
69response to type I interferon (GO:0034340)3.23878366
70response to host immune response (GO:0052572)3.23303466
71response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.23303466
72immunoglobulin mediated immune response (GO:0016064)3.21914020
73regulation of B cell differentiation (GO:0045577)3.21742503
74mature B cell differentiation (GO:0002335)3.19957207
75leukocyte degranulation (GO:0043299)3.15228013
76thrombin receptor signaling pathway (GO:0070493)3.13714211
77positive regulation of mast cell activation involved in immune response (GO:0033008)3.13691964
78positive regulation of mast cell degranulation (GO:0043306)3.13691964
79germinal center formation (GO:0002467)3.13058882
80ribosomal large subunit biogenesis (GO:0042273)3.12765610
81regulation of T-helper 2 cell differentiation (GO:0045628)3.11993668
82regulation of interferon-beta biosynthetic process (GO:0045357)3.10114991
83telomere maintenance via semi-conservative replication (GO:0032201)3.09299628
84positive regulation of cellular amide metabolic process (GO:0034250)3.06163737
85positive thymic T cell selection (GO:0045059)3.04308008
86Arp2/3 complex-mediated actin nucleation (GO:0034314)3.03812510
87macromolecular complex disassembly (GO:0032984)3.03766391
88response to interferon-alpha (GO:0035455)3.02434074
89negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.01958293
90negative regulation of T-helper cell differentiation (GO:0045623)3.01958293
91negative regulation of leukocyte mediated immunity (GO:0002704)3.01116198
92deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.00656717
93regulation of gamma-delta T cell differentiation (GO:0045586)3.00583813
94response to host (GO:0075136)2.99672189
95response to host defenses (GO:0052200)2.99672189
96response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.99672189
97T cell homeostasis (GO:0043029)2.99013524
98negative thymic T cell selection (GO:0045060)2.96963795
99myeloid dendritic cell activation (GO:0001773)2.96801842
100negative regulation of phagocytosis (GO:0050765)2.95874501
101detection of biotic stimulus (GO:0009595)2.94504017
102lymph node development (GO:0048535)2.94416089
103tolerance induction (GO:0002507)2.93663022
104regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.92255798
105regulation of gamma-delta T cell activation (GO:0046643)2.92055561
106positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.91388661
107T cell selection (GO:0045058)2.90562976
108B cell receptor signaling pathway (GO:0050853)2.89158830
109macrophage activation (GO:0042116)2.89047298
110negative T cell selection (GO:0043383)2.88116158
111actin filament polymerization (GO:0030041)2.88088955
112positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.88086097
113positive regulation of T cell mediated cytotoxicity (GO:0001916)2.87828282
114nuclear-transcribed mRNA catabolic process (GO:0000956)2.87823597
115megakaryocyte development (GO:0035855)2.87322507
116detection of molecule of bacterial origin (GO:0032490)2.83192568
117regulation of platelet activation (GO:0010543)2.82164894
118mRNA catabolic process (GO:0006402)2.81324895
119interferon-gamma production (GO:0032609)2.79714391
120endosome to pigment granule transport (GO:0043485)2.78636434
121endosome to melanosome transport (GO:0035646)2.78636434
122regulation of natural killer cell mediated immunity (GO:0002715)2.78512654
123regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.78512654
124G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.77991813
125dendritic cell chemotaxis (GO:0002407)2.77650823
126positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.76210001
127regulation of tolerance induction (GO:0002643)2.76111874
128protein targeting to membrane (GO:0006612)2.75763242
129regulation of T cell mediated cytotoxicity (GO:0001914)2.75378145
130regulation of regulated secretory pathway (GO:1903305)2.75178831
131regulation of alpha-beta T cell proliferation (GO:0046640)2.75095885
132regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.74704307
133telomere maintenance via recombination (GO:0000722)2.74396088
134regulation of T cell receptor signaling pathway (GO:0050856)2.73228669
135regulation of dendritic cell antigen processing and presentation (GO:0002604)2.73180706
136negative regulation of T cell mediated immunity (GO:0002710)2.71695329
137regulation of T cell tolerance induction (GO:0002664)2.71445719
138secretory granule organization (GO:0033363)2.70538619
139mast cell activation involved in immune response (GO:0002279)2.70486174
140mast cell degranulation (GO:0043303)2.70486174
141positive regulation of B cell mediated immunity (GO:0002714)2.70224764
142positive regulation of immunoglobulin mediated immune response (GO:0002891)2.70224764
143positive regulation of granulocyte differentiation (GO:0030854)2.68344861
144B cell mediated immunity (GO:0019724)2.66348253
145negative regulation of nitric oxide biosynthetic process (GO:0045019)2.66262266
146interferon-gamma-mediated signaling pathway (GO:0060333)2.65609136
147RNA catabolic process (GO:0006401)2.65395333
148positive regulation of macrophage differentiation (GO:0045651)2.64542693
149CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.64060948
150positive regulation of antigen processing and presentation (GO:0002579)2.62585880
151negative regulation of granulocyte differentiation (GO:0030853)2.60534876
152leukocyte aggregation (GO:0070486)2.60527736
153purine deoxyribonucleotide catabolic process (GO:0009155)2.59898840
154regulation of respiratory burst (GO:0060263)2.58289774
155regulation of regulatory T cell differentiation (GO:0045589)2.57981907
156T cell migration (GO:0072678)2.56625773
157translation (GO:0006412)2.54159379
158cellular response to zinc ion (GO:0071294)2.54047071
159DNA strand elongation involved in DNA replication (GO:0006271)2.51352338
160NIK/NF-kappaB signaling (GO:0038061)2.49827091
161DNA strand elongation (GO:0022616)2.49557016
162respiratory chain complex IV assembly (GO:0008535)2.49174266
163response to peptidoglycan (GO:0032494)2.48257631
164phospholipid scrambling (GO:0017121)2.45646951
165negative regulation of viral genome replication (GO:0045071)2.45449968
166cellular response to exogenous dsRNA (GO:0071360)2.45111217
167regulation of antigen processing and presentation (GO:0002577)2.44655597
168myeloid dendritic cell differentiation (GO:0043011)2.42383738
169respiratory burst (GO:0045730)2.42037240

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.40338913
2E2F7_22180533_ChIP-Seq_HELA_Human4.12063286
3* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.75346277
4SCL_19346495_ChIP-Seq_HPC-7_Human3.69936771
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.35924527
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.26587611
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.25553668
8SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.11767691
9* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.09886594
10* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.05185878
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.92821472
12FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.87062323
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.82206120
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.78125042
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.76942672
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.64836974
17TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.56298011
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.46677807
19* SPI1_23547873_ChIP-Seq_NB4_Human2.46165147
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.40355274
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33575006
22VDR_21846776_ChIP-Seq_THP-1_Human2.32432729
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.32346670
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31644970
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.30459630
26MYC_18555785_ChIP-Seq_MESCs_Mouse2.26527110
27MYC_22102868_ChIP-Seq_BL_Human2.18536028
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.18460061
29SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.14159228
30* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.10511841
31MYB_26560356_Chip-Seq_TH2_Human2.07945069
32ERG_20887958_ChIP-Seq_HPC-7_Mouse2.06514220
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04673106
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.04514032
35LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.97356787
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.93996315
37* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.93803741
38* IRF8_27001747_Chip-Seq_BMDM_Mouse1.93417771
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.93344865
40GATA1_19941826_ChIP-Seq_K562_Human1.91503869
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.91320278
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.90630539
43VDR_24763502_ChIP-Seq_THP-1_Human1.88793267
44VDR_23849224_ChIP-Seq_CD4+_Human1.87819286
45MAF_26560356_Chip-Seq_TH1_Human1.83911147
46MYB_26560356_Chip-Seq_TH1_Human1.82671251
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82633836
48* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.80320982
49* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79801388
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.79405710
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.77967396
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74795395
53FOXP3_21729870_ChIP-Seq_TREG_Human1.73591592
54* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.72297920
55LXR_22292898_ChIP-Seq_THP-1_Human1.72247381
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.69171355
57* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67196278
58GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.67061805
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64471221
60KDM2B_26808549_Chip-Seq_DND41_Human1.63561353
61GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.61726994
62RUNX_20019798_ChIP-Seq_JUKART_Human1.61680435
63UTX_26944678_Chip-Seq_JUKART_Human1.61297160
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.60222603
65GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.59600706
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.55568235
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.55252259
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53499873
69GATA2_22383799_ChIP-Seq_G1ME_Mouse1.53430131
70GATA2_19941826_ChIP-Seq_K562_Human1.50722420
71E2F4_17652178_ChIP-ChIP_JURKAT_Human1.50241053
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45200787
73CIITA_25753668_ChIP-Seq_RAJI_Human1.43082572
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.42601972
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42272992
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40495137
77GATA2_21666600_ChIP-Seq_HMVEC_Human1.39416984
78KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38526143
79* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38465095
80* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37943414
81VDR_24787735_ChIP-Seq_THP-1_Human1.37469485
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37261090
83* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35979018
84MAF_26560356_Chip-Seq_TH2_Human1.34896129
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33715348
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.32531805
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30448437
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29056122
89MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28033314
90XRN2_22483619_ChIP-Seq_HELA_Human1.27928415
91BCL6_27268052_Chip-Seq_Bcells_Human1.27911926
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27444521
93GATA1_22025678_ChIP-Seq_K562_Human1.24203155
94NCOR1_26117541_ChIP-Seq_K562_Human1.23756313
95* SPI1_23127762_ChIP-Seq_K562_Human1.22234469
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21141855
97TCF7_22412390_ChIP-Seq_EML_Mouse1.20817790
98ELK1_19687146_ChIP-ChIP_HELA_Human1.20740660
99BCOR_27268052_Chip-Seq_Bcells_Human1.20067077
100MYC_19079543_ChIP-ChIP_MESCs_Mouse1.19361717
101CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17164831
102CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15356945
103CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15057901
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13417803
105KDM2B_26808549_Chip-Seq_JURKAT_Human1.12129528
106PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11526328
107CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10905270
108EGR1_19374776_ChIP-ChIP_THP-1_Human1.09290005
109DCP1A_22483619_ChIP-Seq_HELA_Human1.08028947
110* PU_27001747_Chip-Seq_BMDM_Mouse1.07279241
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06247674
112TTF2_22483619_ChIP-Seq_HELA_Human1.05371921
113CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03497343
114ELF1_20517297_ChIP-Seq_JURKAT_Human1.00565732
115SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00353692
116CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00124778
117E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99999967
118GATA3_26560356_Chip-Seq_TH2_Human0.99315239
119TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99039794
120GABP_19822575_ChIP-Seq_HepG2_Human0.99025253
121STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98026456
122SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97710648
123PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97430177
124MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97376620
125SPI1_20517297_ChIP-Seq_HL60_Human0.97262977
126PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96446237
127GATA3_27048872_Chip-Seq_THYMUS_Human0.96288892
128GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95746743
129RACK7_27058665_Chip-Seq_MCF-7_Human0.95379054
130* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95340991
131RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95160583
132TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95000122
133RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94436951
134PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93698241
135GATA1_19941827_ChIP-Seq_MEL_Mouse0.93173001
136YY1_21170310_ChIP-Seq_MESCs_Mouse0.92335875
137P68_20966046_ChIP-Seq_HELA_Human0.91942240
138PPARA_22158963_ChIP-Seq_LIVER_Mouse0.91087080
139NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91042958
140CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90771448
141ETS1_22383799_ChIP-Seq_G1ME_Mouse0.90220361
142SA1_27219007_Chip-Seq_ERYTHROID_Human0.90138436

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.20297937
2MP0005671_abnormal_response_to3.45317049
3MP0002396_abnormal_hematopoietic_system3.35569895
4MP0009785_altered_susceptibility_to3.11790012
5MP0000685_abnormal_immune_system2.95428458
6MP0003763_abnormal_thymus_physiology2.93758323
7MP0001800_abnormal_humoral_immune2.69877389
8MP0005174_abnormal_tail_pigmentation2.66981582
9MP0005025_abnormal_response_to2.64264955
10MP0002148_abnormal_hypersensitivity_rea2.63995029
11MP0003724_increased_susceptibility_to2.62494193
12MP0001873_stomach_inflammation2.52470920
13MP0005000_abnormal_immune_tolerance2.49717812
14MP0002452_abnormal_antigen_presenting2.47924290
15MP0003436_decreased_susceptibility_to2.47580493
16MP0002420_abnormal_adaptive_immunity2.47238538
17MP0001819_abnormal_immune_cell2.44648024
18MP0002723_abnormal_immune_serum2.43854015
19MP0001790_abnormal_immune_system2.38714861
20MP0005387_immune_system_phenotype2.38714861
21MP0008004_abnormal_stomach_pH2.35374966
22MP0002398_abnormal_bone_marrow2.32372109
23MP0000490_abnormal_crypts_of2.30003742
24MP0000465_gastrointestinal_hemorrhage2.27701427
25MP0005464_abnormal_platelet_physiology2.27483014
26MP0002419_abnormal_innate_immunity2.21879982
27MP0002166_altered_tumor_susceptibility2.21807670
28MP0005075_abnormal_melanosome_morpholog2.20109680
29MP0010155_abnormal_intestine_physiology2.17831776
30MP0009379_abnormal_foot_pigmentation2.14334771
31MP0009333_abnormal_splenocyte_physiolog2.11240566
32MP0004808_abnormal_hematopoietic_stem2.10979125
33MP0000716_abnormal_immune_system2.09544208
34MP0003866_abnormal_defecation2.01070985
35MP0000689_abnormal_spleen_morphology1.99956413
36MP0002722_abnormal_immune_system1.92094935
37MP0002405_respiratory_system_inflammati1.88869278
38MP0001986_abnormal_taste_sensitivity1.86262052
39MP0001853_heart_inflammation1.85795191
40MP0002429_abnormal_blood_cell1.82999772
41MP0005397_hematopoietic_system_phenotyp1.80614007
42MP0001545_abnormal_hematopoietic_system1.80614007
43MP0002006_tumorigenesis1.77973559
44MP0002095_abnormal_skin_pigmentation1.77108045
45MP0000015_abnormal_ear_pigmentation1.74569264
46MP0003693_abnormal_embryo_hatching1.60890450
47MP0001845_abnormal_inflammatory_respons1.60103143
48MP0001851_eye_inflammation1.59818228
49MP0000703_abnormal_thymus_morphology1.54901694
50MP0003191_abnormal_cellular_cholesterol1.45707342
51MP0006292_abnormal_olfactory_placode1.42862339
52MP0008058_abnormal_DNA_repair1.42680324
53MP0002132_abnormal_respiratory_system1.40757104
54MP0008260_abnormal_autophagy1.39581231
55MP0006082_CNS_inflammation1.38957237
56MP0005083_abnormal_biliary_tract1.33669465
57MP0008469_abnormal_protein_level1.22935569
58MP0008007_abnormal_cellular_replicative1.21870069
59MP0005451_abnormal_body_composition1.19018691
60MP0005409_darkened_coat_color1.18296321
61MP0001188_hyperpigmentation1.17846601
62MP0004883_abnormal_blood_vessel1.17722487
63MP0005310_abnormal_salivary_gland1.12625090
64MP0002933_joint_inflammation1.11959351
65MP0003075_altered_response_to1.11889696
66MP0001663_abnormal_digestive_system1.11035928
67MP0000858_altered_metastatic_potential1.10735248
68MP0002019_abnormal_tumor_incidence1.10260545
69MP0009278_abnormal_bone_marrow1.08573382
70MP0003303_peritoneal_inflammation1.08482386
71MP0001533_abnormal_skeleton_physiology1.08009857
72MP0004947_skin_inflammation1.07324820
73MP0005166_decreased_susceptibility_to1.02147071
74MP0004381_abnormal_hair_follicle1.01738868
75MP0002277_abnormal_respiratory_mucosa1.00949837
76MP0010094_abnormal_chromosome_stability1.00935515
77MP0000249_abnormal_blood_vessel0.99109960
78MP0009764_decreased_sensitivity_to0.94695282
79MP0004147_increased_porphyrin_level0.93802056
80MP0000372_irregular_coat_pigmentation0.92548900
81MP0005365_abnormal_bile_salt0.88793369
82MP0003077_abnormal_cell_cycle0.86163644
83MP0002138_abnormal_hepatobiliary_system0.85682775
84MP0000343_altered_response_to0.85671914
85MP0003879_abnormal_hair_cell0.85456108
86MP0003786_premature_aging0.84194601
87MP0008057_abnormal_DNA_replication0.84151173
88MP0003690_abnormal_glial_cell0.81017068
89MP0000477_abnormal_intestine_morphology0.80963398
90MP0004510_myositis0.80717026
91MP0003828_pulmonary_edema0.80306043
92MP0008874_decreased_physiological_sensi0.78800397
93MP0003566_abnormal_cell_adhesion0.78674131
94MP0003656_abnormal_erythrocyte_physiolo0.78131186
95MP0005164_abnormal_response_to0.77979867
96MP0000681_abnormal_thyroid_gland0.77829961
97MP0004130_abnormal_muscle_cell0.75452318
98MP0002009_preneoplasia0.75280024
99MP0003045_fibrosis0.74938539
100MP0005390_skeleton_phenotype0.74124945
101MP0003943_abnormal_hepatobiliary_system0.73532810
102MP0003300_gastrointestinal_ulcer0.73501383
103MP0006054_spinal_hemorrhage0.72210095
104MP0005058_abnormal_lysosome_morphology0.71863070
105MP0008995_early_reproductive_senescence0.71611931
106MP0000313_abnormal_cell_death0.70586508
107MP0003795_abnormal_bone_structure0.69156892
108MP0003183_abnormal_peptide_metabolism0.68608444
109MP0003868_abnormal_feces_composition0.68265634
110MP0000371_diluted_coat_color0.67385240
111MP0009840_abnormal_foam_cell0.67028995
112MP0001765_abnormal_ion_homeostasis0.66732802
113MP0009763_increased_sensitivity_to0.65989227
114MP0002075_abnormal_coat/hair_pigmentati0.65896155
115MP0009642_abnormal_blood_homeostasis0.65194828
116MP0003638_abnormal_response/metabolism_0.64684632
117MP0005167_abnormal_blood-brain_barrier0.63534526
118MP0003091_abnormal_cell_migration0.63368522
119MP0003448_altered_tumor_morphology0.63220980
120MP0005085_abnormal_gallbladder_physiolo0.61957971
121MP0003172_abnormal_lysosome_physiology0.61897283
122MP0010329_abnormal_lipoprotein_level0.61501275
123MP0005381_digestive/alimentary_phenotyp0.60228976
124MP0005084_abnormal_gallbladder_morpholo0.60060076
125MP0003453_abnormal_keratinocyte_physiol0.59305693
126MP0009765_abnormal_xenobiotic_induced0.57983569
127MP0004957_abnormal_blastocyst_morpholog0.57707650
128MP0003111_abnormal_nucleus_morphology0.55784907
129MP0001186_pigmentation_phenotype0.55157011
130MP0002998_abnormal_bone_remodeling0.53836747
131MP0003186_abnormal_redox_activity0.52488251

Predicted human phenotypes

RankGene SetZ-score
1Abnormal platelet volume (HP:0011876)4.92540403
2Menorrhagia (HP:0000132)4.87206141
3Elevated erythrocyte sedimentation rate (HP:0003565)4.76262817
4Gingival bleeding (HP:0000225)4.73277437
5IgM deficiency (HP:0002850)4.56444055
6Increased mean platelet volume (HP:0011877)4.51336274
7Myositis (HP:0100614)4.27221835
8Thrombocytosis (HP:0001894)4.23797667
9Reticulocytopenia (HP:0001896)4.23308140
10Abnormality of cells of the erythroid lineage (HP:0012130)4.21441846
11Abnormal number of erythroid precursors (HP:0012131)4.08813972
12Chronic otitis media (HP:0000389)4.00767032
13Recurrent abscess formation (HP:0002722)3.93854668
14Reduced antithrombin III activity (HP:0001976)3.75932689
15Aplastic anemia (HP:0001915)3.72727937
16Type I transferrin isoform profile (HP:0003642)3.63185996
17Recurrent gram-negative bacterial infections (HP:0005420)3.56476153
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.53857124
19Petechiae (HP:0000967)3.53574788
20Prolonged bleeding time (HP:0003010)3.51447989
21Panhypogammaglobulinemia (HP:0003139)3.39853562
22Recurrent bacterial skin infections (HP:0005406)3.36619503
23Recurrent bronchitis (HP:0002837)3.35603506
24Agammaglobulinemia (HP:0004432)3.29485135
25Meningitis (HP:0001287)3.27830620
26Abnormality of T cell physiology (HP:0011840)3.22418237
27Chronic mucocutaneous candidiasis (HP:0002728)3.15940897
28Recurrent cutaneous fungal infections (HP:0011370)3.15940897
29Eczematoid dermatitis (HP:0000976)3.13346627
30Recurrent fungal infections (HP:0002841)3.10817186
31Gastrointestinal infarctions (HP:0005244)3.09057915
32Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.99532066
33Abnormal protein N-linked glycosylation (HP:0012347)2.99532066
34Abnormal protein glycosylation (HP:0012346)2.99532066
35Abnormal glycosylation (HP:0012345)2.99532066
36Recurrent viral infections (HP:0004429)2.96420412
37Inflammation of the large intestine (HP:0002037)2.91437087
38Nasal polyposis (HP:0100582)2.89276264
39Pallor (HP:0000980)2.88026610
40Abnormality of T cells (HP:0002843)2.83760954
41Chest pain (HP:0100749)2.81275898
42Gastrointestinal inflammation (HP:0004386)2.80897143
43Recurrent skin infections (HP:0001581)2.79784629
44Abnormality of the nasal mucosa (HP:0000433)2.76059803
45Obstructive lung disease (HP:0006536)2.75462689
46Chronic obstructive pulmonary disease (HP:0006510)2.75462689
47Gingivitis (HP:0000230)2.74861621
48IgG deficiency (HP:0004315)2.65840616
49Abnormality of the prostate (HP:0008775)2.63891933
50Epistaxis (HP:0000421)2.63475779
51Orchitis (HP:0100796)2.62974051
52Cellulitis (HP:0100658)2.60668191
53Mediastinal lymphadenopathy (HP:0100721)2.56254137
54Urticaria (HP:0001025)2.55874947
55Macrocytic anemia (HP:0001972)2.54871107
56Absent rod-and cone-mediated responses on ERG (HP:0007688)2.54795700
57Vasculitis (HP:0002633)2.52811898
58Arterial thrombosis (HP:0004420)2.52327516
59Increased cerebral lipofuscin (HP:0011813)2.51572265
60Lymphopenia (HP:0001888)2.50097410
61B lymphocytopenia (HP:0010976)2.48812045
62Abnormality of B cell number (HP:0010975)2.48812045
63Optic neuritis (HP:0100653)2.47511466
64Retrobulbar optic neuritis (HP:0100654)2.47511466
65Hyperlipoproteinemia (HP:0010980)2.46622703
66Episodic fever (HP:0001954)2.46379373
67Vacuolated lymphocytes (HP:0001922)2.45502239
68Dysostosis multiplex (HP:0000943)2.44565285
69Abnormality of macrophages (HP:0004311)2.43619078
70Pustule (HP:0200039)2.43468221
71Increased IgM level (HP:0003496)2.43275369
72Chronic diarrhea (HP:0002028)2.41764388
73Abnormality of cells of the lymphoid lineage (HP:0012140)2.41717263
74Pulmonary embolism (HP:0002204)2.40569893
75Systemic lupus erythematosus (HP:0002725)2.40517538
76Encephalitis (HP:0002383)2.40138295
77Increased serum ferritin (HP:0003281)2.39445078
78Hepatosplenomegaly (HP:0001433)2.38459436
79Type 2 muscle fiber atrophy (HP:0003554)2.37413490
80Pulmonary infiltrates (HP:0002113)2.37329247
81Poikiloderma (HP:0001029)2.35693174
82Abnormality of iron homeostasis (HP:0011031)2.35553518
83Thyroiditis (HP:0100646)2.31975639
84Colitis (HP:0002583)2.31854514
85Keratoconjunctivitis sicca (HP:0001097)2.31719602
86Muscle fiber atrophy (HP:0100295)2.30270829
87Bruising susceptibility (HP:0000978)2.29302447
88Leukocytosis (HP:0001974)2.29264495
89Chronic sinusitis (HP:0011109)2.27398792
90Lymphoma (HP:0002665)2.26293381
91Albinism (HP:0001022)2.25327969
92Increased neuronal autofluorescent lipopigment (HP:0002074)2.24623503
93Interstitial pulmonary disease (HP:0006530)2.23554552
94Impaired platelet aggregation (HP:0003540)2.23323343
95Abnormal platelet function (HP:0011869)2.23323343
96Joint swelling (HP:0001386)2.22648572
97Spontaneous hematomas (HP:0007420)2.21951727
98Stomatitis (HP:0010280)2.19611646
99Osteomyelitis (HP:0002754)2.17738100
100Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.17642747
101Decreased activity of mitochondrial respiratory chain (HP:0008972)2.17642747
102Microcytic anemia (HP:0001935)2.16919796
103Recurrent sinusitis (HP:0011108)2.16718630
104Pancytopenia (HP:0001876)2.14222754
105Gastrointestinal stroma tumor (HP:0100723)2.12716106
106Polycythemia (HP:0001901)2.12318962
107Keratoconjunctivitis (HP:0001096)2.09037528
108Hypoproteinemia (HP:0003075)2.08456596
109Hypochromic anemia (HP:0001931)2.08165017
110Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07459784
111Hemoptysis (HP:0002105)2.05843860
112Neutropenia (HP:0001875)2.05449751
113Amyloidosis (HP:0011034)2.05363876
114T lymphocytopenia (HP:0005403)2.04016899
115Abnormality of the common coagulation pathway (HP:0010990)2.03606199
116Abnormality of DNA repair (HP:0003254)2.03584160
117Autoimmune hemolytic anemia (HP:0001890)2.03218497
118Granulocytopenia (HP:0001913)2.02256325
119Exertional dyspnea (HP:0002875)2.01253815
120Increased density of long bones (HP:0006392)2.01229718
121Clubbing of toes (HP:0100760)2.01203171
122Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99284693
123Joint hemorrhage (HP:0005261)1.99196159
124Myelodysplasia (HP:0002863)1.98499060
125Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97224948
126Hypergammaglobulinemia (HP:0010702)1.96529025
127Metaphyseal cupping (HP:0003021)1.96277292
128Abnormality of the vasculature of the conjunctiva (HP:0008054)1.95864528
129Abnormality of T cell number (HP:0011839)1.95797079
130Purpura (HP:0000979)1.95698724
131Periodontitis (HP:0000704)1.95155181
132Severe combined immunodeficiency (HP:0004430)1.95030445
133Chromsome breakage (HP:0040012)1.94316498
134Conjunctival telangiectasia (HP:0000524)1.92314558
13511 pairs of ribs (HP:0000878)1.91755001
136Abnormality of lateral ventricle (HP:0030047)1.91727528
137Recurrent lower respiratory tract infections (HP:0002783)1.90598279
138Anorexia (HP:0002039)1.89885053
139Abnormality of transition element cation homeostasis (HP:0011030)1.89863701
140Basal ganglia calcification (HP:0002135)1.89686236
141Hypochromic microcytic anemia (HP:0004840)1.89435356
142Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89058033
143Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88635661
144Restrictive lung disease (HP:0002091)1.88190705
145Increased IgE level (HP:0003212)1.87910482
146Hemorrhage of the eye (HP:0011885)1.84488408
147Arthralgia (HP:0002829)1.84449804
148Vertigo (HP:0002321)1.84283954
149Malnutrition (HP:0004395)1.83664503
150Emphysema (HP:0002097)1.81164549

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.79421550
2NME23.48212847
3KIT3.02872536
4TXK2.66395855
5STK162.65986218
6IRAK42.47620093
7BLK2.38974531
8BTK2.37045042
9TNIK2.27768333
10IKBKE2.14339912
11PRPF4B2.07083227
12IRAK31.88677740
13ZAP701.88406139
14TBK11.86143855
15PIM21.85927422
16EIF2AK31.81958040
17MUSK1.79940044
18FLT31.78621997
19CSF1R1.74004088
20JAK31.69406868
21NLK1.67585209
22FGR1.62935620
23SYK1.62230623
24TRIB31.61311661
25MAP3K121.59490228
26* TEC1.59454144
27CDK191.56268291
28MAP3K141.55657253
29TGFBR21.55549937
30TYK21.48781700
31IKBKB1.47723478
32BMX1.45853747
33EEF2K1.42594952
34TAOK11.36932486
35MAP2K31.35756115
36MAP3K31.35683879
37FES1.34011918
38ADRBK21.33401699
39TGFBR11.33119003
40VRK11.26480023
41TAOK31.26141196
42MKNK21.24793050
43LYN1.24325965
44RPS6KB21.21659118
45EPHB11.21535403
46ACVR1B1.21247828
47MKNK11.20756776
48BMPR21.16162423
49LCK1.16014851
50MAP3K111.14701165
51KDR1.13473771
52TLK11.12109023
53PIM11.10530881
54PDK11.10206744
55CLK11.07153696
56JAK21.04906843
57EIF2AK21.03577018
58WEE11.00847204
59TIE11.00823748
60PDPK10.99682378
61TNK20.99391949
62CAMKK20.98670923
63MAP3K10.98540208
64GRK60.95106204
65MATK0.93976327
66RPS6KA40.93651357
67PTK2B0.91361121
68HCK0.90792277
69CDC42BPA0.89645951
70DYRK30.89413272
71MARK20.88866303
72SIK10.88738906
73ERN10.87576591
74SIK20.86747514
75MAPK120.85945311
76SMG10.85289810
77MARK30.84865253
78ITK0.83607099
79TESK20.82538841
80CDK80.81881627
81MAP2K60.79334539
82LRRK20.78691247
83STK100.76597498
84FGFR40.74921758
85PRKD20.73840926
86IRAK20.73160368
87TAOK20.72169768
88PRKG20.72045165
89RET0.71972920
90MYLK0.69432517
91PKN20.69244492
92KSR20.68609170
93CDK70.67614414
94CHUK0.65883689
95FYN0.65788946
96CSK0.63935938
97CAMK10.63758212
98SRPK10.63181179
99CCNB10.62633660
100MAPKAPK50.62633616
101MAPK110.62000952
102HIPK20.60988539
103SIK30.60383221
104RIPK40.59062046
105PRKCQ0.57644526
106YES10.57476297
107JAK10.55733248
108FGFR30.55387225
109ATR0.53768778
110MAPKAPK30.52766974
111MAPK40.52344648
112TRPM70.52185113
113PTK60.51860460
114BMPR1B0.51515779
115MST40.51227333
116RPS6KA60.48791929
117EIF2AK10.48145898
118GRK50.47438068
119PIK3CG0.47272354
120MAPK70.47078520
121MAP3K20.46821836
122IRAK10.45029447
123CDK40.44499322
124RPS6KA50.44304905
125GRK10.43141239
126PRKD10.41395714
127MAPKAPK20.40594866
128MAP3K100.40143126
129MAP3K70.39708654
130CAMKK10.39305147
131RPS6KC10.38746527
132RPS6KL10.38746527
133SGK30.38081830
134MAP3K130.38064044
135STK240.37283059
136ZAK0.36225977
137MAP3K50.36047809
138STK40.35638422
139CDK120.35481670
140BUB10.34597151
141BRSK20.33302788
142MAP3K60.32322273
143BCKDK0.32143856
144AURKB0.31865046
145MAP2K20.31690019
146EPHA30.31672240
147PRKCD0.26972000
148PAK10.26779470

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.49588937
2Primary immunodeficiency_Homo sapiens_hsa053403.22890143
3DNA replication_Homo sapiens_hsa030303.21666902
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.65078990
5Mismatch repair_Homo sapiens_hsa034302.22008979
6Base excision repair_Homo sapiens_hsa034102.20317577
7Homologous recombination_Homo sapiens_hsa034402.06689771
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.04229688
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.99837526
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.94332585
11Leishmaniasis_Homo sapiens_hsa051401.90800093
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.88552085
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.86479026
14Measles_Homo sapiens_hsa051621.85617537
15Hematopoietic cell lineage_Homo sapiens_hsa046401.84329939
16Type I diabetes mellitus_Homo sapiens_hsa049401.74329426
17Antigen processing and presentation_Homo sapiens_hsa046121.73850387
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.73175224
19Other glycan degradation_Homo sapiens_hsa005111.69345726
20RNA polymerase_Homo sapiens_hsa030201.64991069
21Pyrimidine metabolism_Homo sapiens_hsa002401.64039673
22Allograft rejection_Homo sapiens_hsa053301.60399716
23Herpes simplex infection_Homo sapiens_hsa051681.60232350
24B cell receptor signaling pathway_Homo sapiens_hsa046621.60081406
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.59428512
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.54050107
27Protein export_Homo sapiens_hsa030601.50201765
28Nucleotide excision repair_Homo sapiens_hsa034201.47452859
29Spliceosome_Homo sapiens_hsa030401.39824110
30Fanconi anemia pathway_Homo sapiens_hsa034601.38951021
31Non-homologous end-joining_Homo sapiens_hsa034501.38150348
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.34412772
33Proteasome_Homo sapiens_hsa030501.34001295
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.33998827
35Osteoclast differentiation_Homo sapiens_hsa043801.24977076
36Phagosome_Homo sapiens_hsa041451.22468113
37Non-small cell lung cancer_Homo sapiens_hsa052231.21886823
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21656108
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20292305
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17862942
41Pertussis_Homo sapiens_hsa051331.16598935
42Asthma_Homo sapiens_hsa053101.12179712
43Graft-versus-host disease_Homo sapiens_hsa053321.10922919
44N-Glycan biosynthesis_Homo sapiens_hsa005101.06569501
45Influenza A_Homo sapiens_hsa051641.05714512
46Malaria_Homo sapiens_hsa051441.05334226
47Pancreatic cancer_Homo sapiens_hsa052121.04699167
48Legionellosis_Homo sapiens_hsa051341.02973178
49Acute myeloid leukemia_Homo sapiens_hsa052211.00547428
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99409301
51T cell receptor signaling pathway_Homo sapiens_hsa046600.98655392
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95597319
53VEGF signaling pathway_Homo sapiens_hsa043700.93250745
54Lysosome_Homo sapiens_hsa041420.92957998
55Purine metabolism_Homo sapiens_hsa002300.92843469
56Arachidonic acid metabolism_Homo sapiens_hsa005900.92624163
57Shigellosis_Homo sapiens_hsa051310.92556949
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92547321
59RNA degradation_Homo sapiens_hsa030180.89318107
60Sulfur relay system_Homo sapiens_hsa041220.88937447
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88852497
62Chronic myeloid leukemia_Homo sapiens_hsa052200.87983184
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.87928302
64Endocytosis_Homo sapiens_hsa041440.84908775
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83988209
66p53 signaling pathway_Homo sapiens_hsa041150.82081793
67Basal transcription factors_Homo sapiens_hsa030220.81430617
68Hepatitis B_Homo sapiens_hsa051610.81252162
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.81182593
70Caffeine metabolism_Homo sapiens_hsa002320.80153063
71Toxoplasmosis_Homo sapiens_hsa051450.80051780
72Choline metabolism in cancer_Homo sapiens_hsa052310.79994245
73Apoptosis_Homo sapiens_hsa042100.79579317
74Autoimmune thyroid disease_Homo sapiens_hsa053200.79123783
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78890837
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78590399
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78503459
78Platelet activation_Homo sapiens_hsa046110.78313958
79Tuberculosis_Homo sapiens_hsa051520.76768595
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75999886
81Epstein-Barr virus infection_Homo sapiens_hsa051690.74473048
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73449314
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72423405
84Cell cycle_Homo sapiens_hsa041100.72123934
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.72095499
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70478744
87Renal cell carcinoma_Homo sapiens_hsa052110.68532318
88Folate biosynthesis_Homo sapiens_hsa007900.68373340
89Salmonella infection_Homo sapiens_hsa051320.67226761
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.67018240
91Staphylococcus aureus infection_Homo sapiens_hsa051500.66016628
92Systemic lupus erythematosus_Homo sapiens_hsa053220.65939030
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.64643037
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64585621
95Chemokine signaling pathway_Homo sapiens_hsa040620.64508307
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63429186
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63203543
98TNF signaling pathway_Homo sapiens_hsa046680.62833460
99Pentose phosphate pathway_Homo sapiens_hsa000300.62416951
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61103623
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.60558486
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.60131225
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59029899
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58533393
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57523926
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57373117
107Endometrial cancer_Homo sapiens_hsa052130.57227446
108Hepatitis C_Homo sapiens_hsa051600.55349962
109Amoebiasis_Homo sapiens_hsa051460.53243124
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.52300921
111Prolactin signaling pathway_Homo sapiens_hsa049170.51856939
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51504203
113GnRH signaling pathway_Homo sapiens_hsa049120.49580458
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49573060
115Galactose metabolism_Homo sapiens_hsa000520.48653512
116Complement and coagulation cascades_Homo sapiens_hsa046100.47096820
117HTLV-I infection_Homo sapiens_hsa051660.45966241
118Linoleic acid metabolism_Homo sapiens_hsa005910.45164810
119Pancreatic secretion_Homo sapiens_hsa049720.44433194
120Glycerolipid metabolism_Homo sapiens_hsa005610.44386281
121Insulin resistance_Homo sapiens_hsa049310.44238252
122mTOR signaling pathway_Homo sapiens_hsa041500.43298118
123Type II diabetes mellitus_Homo sapiens_hsa049300.42924302
124Viral carcinogenesis_Homo sapiens_hsa052030.41574487
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41371995
126FoxO signaling pathway_Homo sapiens_hsa040680.41298101
127Rap1 signaling pathway_Homo sapiens_hsa040150.41097576
128RNA transport_Homo sapiens_hsa030130.39819941
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38794057
130One carbon pool by folate_Homo sapiens_hsa006700.38531007
131African trypanosomiasis_Homo sapiens_hsa051430.38150754
132Inositol phosphate metabolism_Homo sapiens_hsa005620.36762927
133Collecting duct acid secretion_Homo sapiens_hsa049660.36101523
134HIF-1 signaling pathway_Homo sapiens_hsa040660.34545189
135Renin-angiotensin system_Homo sapiens_hsa046140.34503075
136Rheumatoid arthritis_Homo sapiens_hsa053230.33598705
137Notch signaling pathway_Homo sapiens_hsa043300.32994568
138Drug metabolism - other enzymes_Homo sapiens_hsa009830.32684692
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32630741
140Thyroid cancer_Homo sapiens_hsa052160.31329548
141Viral myocarditis_Homo sapiens_hsa054160.29824841
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28357365

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