PTPN12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.83051684
2positive regulation by symbiont of host defense response (GO:0052509)4.68431312
3modulation by symbiont of host defense response (GO:0052031)4.68431312
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.68431312
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.68431312
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.68431312
7modulation by symbiont of host immune response (GO:0052553)4.68431312
8hypotonic response (GO:0006971)3.93363884
9cell adhesion mediated by integrin (GO:0033627)3.79001823
10response to peptidoglycan (GO:0032494)3.60640359
11definitive hemopoiesis (GO:0060216)3.55168624
12wound healing, spreading of epidermal cells (GO:0035313)3.52684371
13positive regulation of interferon-alpha production (GO:0032727)3.41698059
14regulation of platelet activation (GO:0010543)3.36794585
15macrophage activation involved in immune response (GO:0002281)3.26601396
16regulation of interferon-alpha production (GO:0032647)3.23317067
17leukocyte migration involved in inflammatory response (GO:0002523)3.21397157
18neutrophil activation involved in immune response (GO:0002283)3.20365597
19positive regulation of receptor recycling (GO:0001921)3.12370408
20positive regulation of cellular amide metabolic process (GO:0034250)3.07992154
21response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.07146831
22response to host immune response (GO:0052572)3.07146831
23Arp2/3 complex-mediated actin nucleation (GO:0034314)3.04859757
24positive regulation of hemostasis (GO:1900048)3.04737186
25positive regulation of blood coagulation (GO:0030194)3.04737186
26immunoglobulin mediated immune response (GO:0016064)3.04321470
27endothelium development (GO:0003158)3.03369018
28regulation of early endosome to late endosome transport (GO:2000641)3.02914435
29stress fiber assembly (GO:0043149)3.02752778
30response to muramyl dipeptide (GO:0032495)3.01570760
31positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.01502137
32morphogenesis of an endothelium (GO:0003159)2.97657331
33endothelial tube morphogenesis (GO:0061154)2.97657331
34positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.97419611
35angiogenesis involved in wound healing (GO:0060055)2.96861900
36thrombin receptor signaling pathway (GO:0070493)2.96858450
37positive regulation of coagulation (GO:0050820)2.96335871
38regulation of interferon-beta biosynthetic process (GO:0045357)2.96147991
39vascular endothelial growth factor signaling pathway (GO:0038084)2.95875015
40regulation of integrin activation (GO:0033623)2.95630116
41response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.93322154
42response to host (GO:0075136)2.93322154
43response to host defenses (GO:0052200)2.93322154
44regulation of T-helper 2 cell differentiation (GO:0045628)2.92885607
45response to interferon-alpha (GO:0035455)2.91530131
46positive regulation of mast cell activation (GO:0033005)2.90763013
47regulation of meiosis I (GO:0060631)2.89860418
48substrate-dependent cell migration (GO:0006929)2.89335619
49regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.87339795
50apoptotic cell clearance (GO:0043277)2.87002620
51production of molecular mediator involved in inflammatory response (GO:0002532)2.82396250
52germ cell migration (GO:0008354)2.82056622
53negative regulation of protein localization to plasma membrane (GO:1903077)2.81984797
54lipopolysaccharide-mediated signaling pathway (GO:0031663)2.81145058
55regulation of platelet aggregation (GO:0090330)2.80663416
56positive regulation of chemokine biosynthetic process (GO:0045080)2.77956567
57granulocyte activation (GO:0036230)2.75599874
58phagocytosis, engulfment (GO:0006911)2.75349977
59regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.73173400
60positive regulation of focal adhesion assembly (GO:0051894)2.73047982
61positive regulation of cell junction assembly (GO:1901890)2.73047982
62negative regulation of homotypic cell-cell adhesion (GO:0034111)2.68886776
63positive regulation of adherens junction organization (GO:1903393)2.68336557
64positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.67551454
65basement membrane organization (GO:0071711)2.66910224
66negative regulation of platelet activation (GO:0010544)2.66602912
67negative regulation of interleukin-12 production (GO:0032695)2.65132456
68positive regulation of interferon-beta production (GO:0032728)2.64234978
69positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.64114350
70mitotic sister chromatid cohesion (GO:0007064)2.63751114
71endodermal cell differentiation (GO:0035987)2.63320349
72positive regulation of protein import into nucleus, translocation (GO:0033160)2.63316377
73skin morphogenesis (GO:0043589)2.63315900
74protein localization to endosome (GO:0036010)2.62989715
75neutrophil activation (GO:0042119)2.60813714
76I-kappaB phosphorylation (GO:0007252)2.59544823
77blood vessel maturation (GO:0001955)2.59213482
78cellular extravasation (GO:0045123)2.58472803
79positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.57809024
80negative regulation of interleukin-17 production (GO:0032700)2.57784978
81natural killer cell mediated cytotoxicity (GO:0042267)2.57414467
82natural killer cell mediated immunity (GO:0002228)2.57414467
83cellular response to virus (GO:0098586)2.56671823
84negative regulation of focal adhesion assembly (GO:0051895)2.56477145
85negative regulation of cell junction assembly (GO:1901889)2.56477145
86negative regulation of adherens junction organization (GO:1903392)2.56477145
87regulation of T-helper 1 cell differentiation (GO:0045625)2.54981992
88adenosine receptor signaling pathway (GO:0001973)2.54567460
89positive regulation of gamma-delta T cell activation (GO:0046645)2.54180257
90regulation of podosome assembly (GO:0071801)2.52262218
91retina vasculature morphogenesis in camera-type eye (GO:0061299)2.51247793
92detection of molecule of bacterial origin (GO:0032490)2.50506276
93cellular response to interferon-alpha (GO:0035457)2.50063200
94nerve growth factor signaling pathway (GO:0038180)2.47126949
95low-density lipoprotein particle clearance (GO:0034383)2.47061640
96mRNA transcription (GO:0009299)2.46709270
97respiratory burst (GO:0045730)2.46371305
98regulation of cholesterol storage (GO:0010885)2.46151656
99mesodermal cell differentiation (GO:0048333)2.45234082
100SMAD protein complex assembly (GO:0007183)2.44801519
101positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.44291564
102membrane invagination (GO:0010324)2.43323204
103Rap protein signal transduction (GO:0032486)2.42859971
104positive regulation of vasculogenesis (GO:2001214)2.42768526
105epithelial cell-cell adhesion (GO:0090136)2.41320194
106cellular response to thyroid hormone stimulus (GO:0097067)2.40607843
107megakaryocyte development (GO:0035855)2.39975657
108positive regulation of SMAD protein import into nucleus (GO:0060391)2.37754355
109negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.37113733
110positive regulation of leukocyte degranulation (GO:0043302)2.36907797
111negative regulation of stress fiber assembly (GO:0051497)2.36512990
112establishment of endothelial barrier (GO:0061028)2.36139386
113B cell mediated immunity (GO:0019724)2.35982094
114regulation of cell junction assembly (GO:1901888)2.35946485
115negative regulation of lipid storage (GO:0010888)2.35465992
116regulation of membrane protein ectodomain proteolysis (GO:0051043)2.33961429
117regulation of SMAD protein import into nucleus (GO:0060390)2.33878267
118positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.33842478
119regulation of mast cell degranulation (GO:0043304)2.33678851
120leukocyte cell-cell adhesion (GO:0007159)2.33329509
121hydrogen peroxide biosynthetic process (GO:0050665)2.32989178
122positive regulation of endothelial cell apoptotic process (GO:2000353)2.32396375
123positive regulation of p38MAPK cascade (GO:1900745)2.32217267
124superoxide anion generation (GO:0042554)2.30345682
125actin nucleation (GO:0045010)2.29528237
126regulation of mast cell activation (GO:0033003)2.28452582
127cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.28389349
128peptide catabolic process (GO:0043171)2.28222077
129regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.27473970
130regulation of cell-substrate junction assembly (GO:0090109)2.27371803
131regulation of focal adhesion assembly (GO:0051893)2.27371803
132regulation of heterotypic cell-cell adhesion (GO:0034114)2.27045691
133regulation of integrin-mediated signaling pathway (GO:2001044)2.26904710
134macrophage activation (GO:0042116)2.26299926
135regulation of adherens junction organization (GO:1903391)2.26186914
136negative regulation of T-helper cell differentiation (GO:0045623)2.25395306
137negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.25395306
138positive regulation of Cdc42 GTPase activity (GO:0043089)2.25316823
139intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.24963396
140regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.24865457
141positive regulation of interleukin-6 production (GO:0032755)2.24167629
142pinocytosis (GO:0006907)2.24162623
143response to vitamin D (GO:0033280)2.23659112
144regulation of leukocyte degranulation (GO:0043300)2.23488881
145regulation of macrophage cytokine production (GO:0010935)2.23155245
146response to laminar fluid shear stress (GO:0034616)2.22786445
147positive regulation of mast cell activation involved in immune response (GO:0033008)2.22505927
148positive regulation of mast cell degranulation (GO:0043306)2.22505927
149positive regulation of Rho protein signal transduction (GO:0035025)2.21954493
150regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.21744701
151regulation of mast cell activation involved in immune response (GO:0033006)2.21576771
152lymphangiogenesis (GO:0001946)2.21023262
153wound healing, spreading of cells (GO:0044319)2.21022017
154integrin-mediated signaling pathway (GO:0007229)2.20968315
155lymph vessel development (GO:0001945)2.20786865
156positive regulation vascular endothelial growth factor production (GO:0010575)2.20109906
157hippo signaling (GO:0035329)2.19304743
158pathway-restricted SMAD protein phosphorylation (GO:0060389)2.19251555
159leukocyte aggregation (GO:0070486)2.19171475
160myeloid cell homeostasis (GO:0002262)2.18495355

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human5.53888765
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.29245325
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.14029362
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.40553586
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.31941980
6* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.16001518
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.00595511
8* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.94212094
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.90314674
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83666042
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.82649543
12E2F7_22180533_ChIP-Seq_HELA_Human2.78195005
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.76273769
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.67057105
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.67004269
16* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.52586865
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.40851326
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.37595375
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.34364662
20SCL_19346495_ChIP-Seq_HPC-7_Human2.33367312
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.32146150
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.22066431
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.22066431
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.22066431
25TRIM28_21343339_ChIP-Seq_HEK293_Human2.21746427
26STAT6_21828071_ChIP-Seq_BEAS2B_Human2.15846569
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.09648557
28BRD4_27068464_Chip-Seq_AML-cells_Mouse2.05642255
29CLOCK_20551151_ChIP-Seq_293T_Human2.01781028
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.97395663
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.95853255
32TCF7_22412390_ChIP-Seq_EML_Mouse1.87149955
33* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.82941997
34* GATA2_21666600_ChIP-Seq_HMVEC_Human1.82884723
35* ELK3_25401928_ChIP-Seq_HUVEC_Human1.81253897
36GATA1_22025678_ChIP-Seq_K562_Human1.76558424
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74967478
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74724525
39SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.72590160
40SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.72590160
41* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.71871618
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.69283747
43* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64636084
44MYC_22102868_ChIP-Seq_BL_Human1.64213277
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.62760462
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62184641
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60789805
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58709177
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56488900
50RUNX_20019798_ChIP-Seq_JUKART_Human1.55895475
51BRD4_25478319_ChIP-Seq_HGPS_Human1.55716943
52VDR_24763502_ChIP-Seq_THP-1_Human1.55106056
53* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.53904862
54MAF_26560356_Chip-Seq_TH1_Human1.52849098
55* SPI1_23547873_ChIP-Seq_NB4_Human1.51242488
56SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50768244
57WT1_19549856_ChIP-ChIP_CCG9911_Human1.48942712
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47163280
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47049842
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44330359
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43991494
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.42971190
63* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38558724
64ESR1_21235772_ChIP-Seq_MCF-7_Human1.36697738
65* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.35990791
66PU_27001747_Chip-Seq_BMDM_Mouse1.35712687
67* RUNX1_22412390_ChIP-Seq_EML_Mouse1.35336721
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.35312806
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34745363
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34477457
71VDR_24787735_ChIP-Seq_THP-1_Human1.33864874
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33814453
73MYB_26560356_Chip-Seq_TH2_Human1.33011073
74PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31838393
75STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30509754
76ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27931532
77VDR_21846776_ChIP-Seq_THP-1_Human1.27658847
78CJUN_26792858_Chip-Seq_BT549_Human1.26582628
79ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.26053763
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26019743
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25355251
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.24885625
83* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24792540
84MYB_26560356_Chip-Seq_TH1_Human1.24132830
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23034527
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22121495
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.20770881
88* SPI1_23127762_ChIP-Seq_K562_Human1.20682979
89KDM2B_26808549_Chip-Seq_DND41_Human1.17690884
90TP53_16413492_ChIP-PET_HCT116_Human1.17565521
91* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17080244
92* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15191404
93TCF4_18268006_ChIP-ChIP_LS174T_Human1.14786309
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13682251
95PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.13092195
96* TP63_23658742_ChIP-Seq_EP156T_Human1.12634131
97UBF1/2_26484160_Chip-Seq_HMECs_Human1.11918858
98SOX2_20726797_ChIP-Seq_SW620_Human1.11715123
99NCOR1_26117541_ChIP-Seq_K562_Human1.11010698
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10385874
101UTX_26944678_Chip-Seq_JUKART_Human1.10322356
102RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10258235
103SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10120706
104SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09829336
105TP63_19390658_ChIP-ChIP_HaCaT_Human1.09818522
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09497217
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08706282
108PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.08227986
109SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06870788
110ESR2_21235772_ChIP-Seq_MCF-7_Human1.06708952
111* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06397032
112EP300_21415370_ChIP-Seq_HL-1_Mouse1.06338379
113JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06167995
114NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05955443
115* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.05548919
116* ATF3_27146783_Chip-Seq_COLON_Human1.03764578
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03033788
118ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01771242
119GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00918394
120FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00910521
121GATA1_19941826_ChIP-Seq_K562_Human1.00724965
122RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99063412
123P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99001768
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98293575
125GATA2_19941826_ChIP-Seq_K562_Human0.96661826
126* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94887038
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94681317
128NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94681317
129TCF3_18692474_ChIP-Seq_MESCs_Mouse0.94659471
130SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94603705
131JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94136402
132KDM2B_26808549_Chip-Seq_JURKAT_Human0.94010917
133EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91711242
134NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91258748
135ELK4_26923725_Chip-Seq_MESODERM_Mouse0.90540218
136TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90031056
137FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89549905
138CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89368652

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.09654452
2MP0008004_abnormal_stomach_pH3.08054393
3MP0003705_abnormal_hypodermis_morpholog3.07485579
4MP0003436_decreased_susceptibility_to2.68695906
5MP0009278_abnormal_bone_marrow2.63952214
6MP0003724_increased_susceptibility_to2.63627185
7MP0003566_abnormal_cell_adhesion2.51540920
8MP0010352_gastrointestinal_tract_polyps2.29997732
9MP0010368_abnormal_lymphatic_system2.25396990
10MP0005076_abnormal_cell_differentiation2.23941832
11MP0001879_abnormal_lymphatic_vessel2.18709159
12MP0005167_abnormal_blood-brain_barrier1.99623287
13MP0003828_pulmonary_edema1.98529505
14MP0002419_abnormal_innate_immunity1.97607366
15MP0008438_abnormal_cutaneous_collagen1.97274426
16MP0004808_abnormal_hematopoietic_stem1.86722450
17MP0003448_altered_tumor_morphology1.85201598
18MP0009785_altered_susceptibility_to1.84020384
19MP0002877_abnormal_melanocyte_morpholog1.83875003
20MP0000343_altered_response_to1.82182035
21MP0004510_myositis1.81809033
22MP0001958_emphysema1.81686525
23MP0001835_abnormal_antigen_presentation1.77966152
24MP0004272_abnormal_basement_membrane1.77118766
25MP0001545_abnormal_hematopoietic_system1.77087201
26MP0005397_hematopoietic_system_phenotyp1.77087201
27MP0005409_darkened_coat_color1.76960216
28MP0001533_abnormal_skeleton_physiology1.74494138
29MP0003279_aneurysm1.66064102
30MP0002796_impaired_skin_barrier1.65711448
31MP0000733_abnormal_muscle_development1.63659884
32MP0005464_abnormal_platelet_physiology1.61870322
33MP0000569_abnormal_digit_pigmentation1.61808671
34MP0005025_abnormal_response_to1.54638529
35MP0008260_abnormal_autophagy1.53480690
36MP0003300_gastrointestinal_ulcer1.51467881
37* MP0005000_abnormal_immune_tolerance1.50520788
38MP0003091_abnormal_cell_migration1.48515636
39MP0002452_abnormal_antigen_presenting1.47761984
40MP0000465_gastrointestinal_hemorrhage1.47532431
41MP0003950_abnormal_plasma_membrane1.46768837
42MP0004883_abnormal_blood_vessel1.45690013
43MP0006082_CNS_inflammation1.45495147
44MP0002148_abnormal_hypersensitivity_rea1.43315909
45MP0000767_abnormal_smooth_muscle1.42478129
46MP0003656_abnormal_erythrocyte_physiolo1.37837066
47MP0006054_spinal_hemorrhage1.37715646
48MP0010307_abnormal_tumor_latency1.32151329
49MP0002405_respiratory_system_inflammati1.31684392
50MP0004947_skin_inflammation1.31416111
51MP0005023_abnormal_wound_healing1.30198737
52MP0005257_abnormal_intraocular_pressure1.29774285
53MP0004084_abnormal_cardiac_muscle1.28481496
54MP0003941_abnormal_skin_development1.26533229
55MP0001853_heart_inflammation1.24925790
56MP0002254_reproductive_system_inflammat1.23693988
57MP0002998_abnormal_bone_remodeling1.22072995
58MP0000858_altered_metastatic_potential1.21717985
59MP0005275_abnormal_skin_tensile1.21346898
60* MP0001819_abnormal_immune_cell1.20917766
61* MP0002420_abnormal_adaptive_immunity1.20306855
62MP0005058_abnormal_lysosome_morphology1.18229111
63MP0010234_abnormal_vibrissa_follicle1.17573080
64* MP0002723_abnormal_immune_serum1.16541397
65MP0003183_abnormal_peptide_metabolism1.16236914
66MP0001800_abnormal_humoral_immune1.14518300
67MP0005390_skeleton_phenotype1.12247038
68MP0001915_intracranial_hemorrhage1.12148759
69MP0009764_decreased_sensitivity_to1.11674235
70MP0010155_abnormal_intestine_physiology1.11633390
71MP0003453_abnormal_keratinocyte_physiol1.09221426
72MP0005164_abnormal_response_to1.09115656
73MP0003567_abnormal_fetal_cardiomyocyte1.08934681
74MP0005666_abnormal_adipose_tissue1.07574193
75MP0005387_immune_system_phenotype1.06885172
76MP0001790_abnormal_immune_system1.06885172
77MP0002006_tumorigenesis1.06770913
78MP0002396_abnormal_hematopoietic_system1.06082078
79MP0001845_abnormal_inflammatory_respons1.05024239
80MP0003890_abnormal_embryonic-extraembry1.04970354
81MP0005174_abnormal_tail_pigmentation1.04876622
82MP0003075_altered_response_to1.01410995
83MP0005166_decreased_susceptibility_to1.01163431
84MP0005671_abnormal_response_to1.01084888
85MP0002138_abnormal_hepatobiliary_system1.00791801
86MP0001849_ear_inflammation1.00066747
87MP0001851_eye_inflammation0.99158548
88MP0003172_abnormal_lysosome_physiology0.98371609
89MP0009053_abnormal_anal_canal0.97491079
90* MP0002398_abnormal_bone_marrow0.96948556
91MP0002128_abnormal_blood_circulation0.96857808
92* MP0002925_abnormal_cardiovascular_devel0.96463887
93MP0005623_abnormal_meninges_morphology0.96144413
94* MP0001614_abnormal_blood_vessel0.95002529
95MP0009384_cardiac_valve_regurgitation0.94550223
96* MP0002086_abnormal_extraembryonic_tissu0.94495623
97MP0004185_abnormal_adipocyte_glucose0.92530651
98MP0006138_congestive_heart_failure0.91124774
99MP0005595_abnormal_vascular_smooth0.90670134
100MP0000750_abnormal_muscle_regeneration0.89909068
101MP0002133_abnormal_respiratory_system0.89723049
102MP0005388_respiratory_system_phenotype0.89723049
103MP0004782_abnormal_surfactant_physiolog0.89332739
104MP0000249_abnormal_blood_vessel0.89197411
105MP0010678_abnormal_skin_adnexa0.89041970
106MP0008469_abnormal_protein_level0.87683344
107MP0005367_renal/urinary_system_phenotyp0.86095626
108MP0000516_abnormal_urinary_system0.86095626
109* MP0000716_abnormal_immune_system0.86079014
110MP0001216_abnormal_epidermal_layer0.85921170
111MP0002060_abnormal_skin_morphology0.84455439
112MP0000490_abnormal_crypts_of0.84196395
113MP0003221_abnormal_cardiomyocyte_apopto0.83127562
114MP0001730_embryonic_growth_arrest0.82903511
115MP0005501_abnormal_skin_physiology0.82690450
116MP0005621_abnormal_cell_physiology0.82668580
117MP0001542_abnormal_bone_strength0.81831969
118MP0005451_abnormal_body_composition0.80807742
119MP0000383_abnormal_hair_follicle0.80093329
120* MP0002429_abnormal_blood_cell0.79496953
121MP0005248_abnormal_Harderian_gland0.76805820
122MP0002722_abnormal_immune_system0.76651436
123MP0003191_abnormal_cellular_cholesterol0.76368648
124MP0000685_abnormal_immune_system0.76087955
125MP0009840_abnormal_foam_cell0.75472040
126MP0002089_abnormal_postnatal_growth/wei0.75319534
127MP0004197_abnormal_fetal_growth/weight/0.75263276
128MP0002166_altered_tumor_susceptibility0.73177492
129MP0002896_abnormal_bone_mineralization0.71957848
130MP0010630_abnormal_cardiac_muscle0.71472799
131MP0001175_abnormal_lung_morphology0.71241708
132MP0001784_abnormal_fluid_regulation0.68657223

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.46953219
2Recurrent abscess formation (HP:0002722)4.18414227
3Recurrent gram-negative bacterial infections (HP:0005420)3.91423984
4Recurrent bacterial skin infections (HP:0005406)3.85492244
5Hematochezia (HP:0002573)3.76011276
6Interstitial pulmonary disease (HP:0006530)3.20286414
7Papillary thyroid carcinoma (HP:0002895)3.08236118
8Ankle contracture (HP:0006466)2.96703137
9Prolonged bleeding time (HP:0003010)2.86000992
10Protrusio acetabuli (HP:0003179)2.84039173
11Increased cerebral lipofuscin (HP:0011813)2.83962186
12Syringomyelia (HP:0003396)2.82210924
13Spinal cord lesions (HP:0100561)2.82210924
14Abnormality of macrophages (HP:0004311)2.77992296
15Osteolytic defects of the hand bones (HP:0009699)2.77395901
16Osteolytic defects of the phalanges of the hand (HP:0009771)2.77395901
17Mediastinal lymphadenopathy (HP:0100721)2.71795816
18Subacute progressive viral hepatitis (HP:0006572)2.71438171
19Disinhibition (HP:0000734)2.69072874
20Vascular tortuosity (HP:0004948)2.66681665
21Autoimmune thrombocytopenia (HP:0001973)2.64395029
22Thick nail (HP:0001805)2.63452223
23Orchitis (HP:0100796)2.62695909
24Petechiae (HP:0000967)2.60950236
25Increased neuronal autofluorescent lipopigment (HP:0002074)2.60895741
26Arterial tortuosity (HP:0005116)2.58951990
27Myositis (HP:0100614)2.58491138
28Premature rupture of membranes (HP:0001788)2.52538318
29Increased mean platelet volume (HP:0011877)2.52179455
30Esophageal varix (HP:0002040)2.51948032
31Elevated erythrocyte sedimentation rate (HP:0003565)2.50668039
32Cervical subluxation (HP:0003308)2.49966674
33Myocardial infarction (HP:0001658)2.48861853
34Abnormal platelet volume (HP:0011876)2.45277581
35Cellulitis (HP:0100658)2.42061448
36Ankyloglossia (HP:0010296)2.39616887
37Curly hair (HP:0002212)2.39052814
38Shallow orbits (HP:0000586)2.37470401
39Menorrhagia (HP:0000132)2.37355822
40Gingivitis (HP:0000230)2.33175063
41Cerebral aneurysm (HP:0004944)2.31719644
42Peritonitis (HP:0002586)2.29767618
43Spontaneous hematomas (HP:0007420)2.29430064
44Gingival bleeding (HP:0000225)2.28444491
45Absent frontal sinuses (HP:0002688)2.27745540
46Chronic obstructive pulmonary disease (HP:0006510)2.25659007
47Obstructive lung disease (HP:0006536)2.25659007
48Vertebral arch anomaly (HP:0008438)2.25191812
49Abnormality of the common coagulation pathway (HP:0010990)2.23872336
50Recurrent skin infections (HP:0001581)2.23653689
51Recurrent fungal infections (HP:0002841)2.23069837
52Tetraparesis (HP:0002273)2.22882206
53Dilatation of the ascending aorta (HP:0005111)2.21766493
54Impaired platelet aggregation (HP:0003540)2.21058725
55Abnormal platelet function (HP:0011869)2.21058725
56Periodontitis (HP:0000704)2.19200885
57Abnormality of the nasal septum (HP:0000419)2.16295069
58Metaphyseal cupping (HP:0003021)2.14050465
59Mitral valve prolapse (HP:0001634)2.13305634
60Epistaxis (HP:0000421)2.12544844
61Arterial thrombosis (HP:0004420)2.10584971
62Aortic aneurysm (HP:0004942)2.10459549
63Vertebral compression fractures (HP:0002953)2.09685361
64Radial bowing (HP:0002986)2.09165396
65Prostate neoplasm (HP:0100787)2.07892582
66Increased connective tissue (HP:0009025)2.05126237
67Asymmetry of the thorax (HP:0001555)2.04385397
68Purpura (HP:0000979)2.01673912
69* Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.01050364
70Termporal pattern (HP:0011008)1.97024123
71Insidious onset (HP:0003587)1.97024123
72Polycythemia (HP:0001901)1.96624119
73Axonal loss (HP:0003447)1.96023605
74Systemic lupus erythematosus (HP:0002725)1.95846260
75Leukocytosis (HP:0001974)1.95564036
76Retrobulbar optic neuritis (HP:0100654)1.94471279
77Optic neuritis (HP:0100653)1.94471279
78Thin bony cortex (HP:0002753)1.93025437
79Conjunctival telangiectasia (HP:0000524)1.92977439
80Short 4th metacarpal (HP:0010044)1.89569983
81Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.89569983
82* Transitional cell carcinoma of the bladder (HP:0006740)1.88919511
83Acute myeloid leukemia (HP:0004808)1.88423271
84Abnormality of oral frenula (HP:0000190)1.87167155
85Viral hepatitis (HP:0006562)1.86346032
86Rectal prolapse (HP:0002035)1.86233859
87Increased density of long bones (HP:0006392)1.86232365
88Amaurosis fugax (HP:0100576)1.85686120
89Biliary tract neoplasm (HP:0100574)1.85299829
90Broad face (HP:0000283)1.84657761
91Aortic dissection (HP:0002647)1.83639447
92* Bladder carcinoma (HP:0002862)1.83528815
93* Bladder neoplasm (HP:0009725)1.83528815
94Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82687002
95Bruising susceptibility (HP:0000978)1.81967917
96Micronodular cirrhosis (HP:0001413)1.81057696
97Nephritis (HP:0000123)1.80551598
98Abnormality of the pericardium (HP:0001697)1.79522607
99Abnormality of the distal phalanges of the toes (HP:0010182)1.79502099
100Deep philtrum (HP:0002002)1.78847189
101* Gastrointestinal carcinoma (HP:0002672)1.77954047
102* Malignant gastrointestinal tract tumors (HP:0006749)1.77954047
103Hemorrhage of the eye (HP:0011885)1.77302823
104Upper motor neuron abnormality (HP:0002127)1.76569476
105Pustule (HP:0200039)1.76491816
106Coarse hair (HP:0002208)1.76070502
107Spondylolisthesis (HP:0003302)1.75860822
108Thyroid carcinoma (HP:0002890)1.74877691
109Abnormality of the vasculature of the conjunctiva (HP:0008054)1.74119079
110Agnosia (HP:0010524)1.73987808
111Right ventricular cardiomyopathy (HP:0011663)1.73772083
112Urticaria (HP:0001025)1.73409453
113Recurrent viral infections (HP:0004429)1.72691484
114Wrist flexion contracture (HP:0001239)1.70992678
115Atrophic scars (HP:0001075)1.70686405
116* Uterine leiomyosarcoma (HP:0002891)1.70513153
117* Leiomyosarcoma (HP:0100243)1.70513153
118Biconcave vertebral bodies (HP:0004586)1.70200479
119Bilateral sensorineural hearing impairment (HP:0008619)1.69334753
120Fused cervical vertebrae (HP:0002949)1.68364010
121Volvulus (HP:0002580)1.67585385
122Amyloidosis (HP:0011034)1.66878742
123Flat acetabular roof (HP:0003180)1.66527520
124Neurofibrillary tangles (HP:0002185)1.66018672
125Abnormality of liposaccharide metabolism (HP:0010968)1.65261241
126Abnormality of glycosphingolipid metabolism (HP:0004343)1.65261241
127Abnormality of glycolipid metabolism (HP:0010969)1.65261241
128Keratoconjunctivitis sicca (HP:0001097)1.64915352
129Vasculitis (HP:0002633)1.63882987
130Portal hypertension (HP:0001409)1.62159738
131Mitral stenosis (HP:0001718)1.62026234
132Genu recurvatum (HP:0002816)1.60387472
133Bone pain (HP:0002653)1.58021660
134Porencephaly (HP:0002132)1.57811365
135Spinal rigidity (HP:0003306)1.57710501
136Abnormal vertebral ossification (HP:0100569)1.56921165
137Pulmonary infiltrates (HP:0002113)1.56554400
138Rickets (HP:0002748)1.55977462
139Abnormality of the fingertips (HP:0001211)1.55842047
140Long eyelashes (HP:0000527)1.55489992
141Cerebral inclusion bodies (HP:0100314)1.54835615
142Dysostosis multiplex (HP:0000943)1.54090885
143Abnormal auditory evoked potentials (HP:0006958)1.53866397
144Tibial bowing (HP:0002982)1.53731997
145Pulmonic stenosis (HP:0001642)1.53144091
146Absent hand (HP:0004050)1.51775397
147Blepharitis (HP:0000498)1.49485837
148Cortical dysplasia (HP:0002539)1.49221995
149Loss of speech (HP:0002371)1.47538114
150Thoracolumbar scoliosis (HP:0002944)1.46591638

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE13.66174911
2RIPK42.75487187
3YES12.46720143
4MAP3K142.45550168
5KDR2.23785579
6TGFBR12.22840255
7INSRR2.16300851
8PNCK2.08801804
9TRIB32.01715175
10TTN2.00425576
11TGFBR21.99956135
12ERN11.99625928
13TBK11.99582223
14MAP2K31.96405666
15LATS21.88573545
16CDK121.84341005
17PKN21.82731680
18IRAK41.82122350
19MAP3K31.77841874
20STK31.77541724
21RIPK11.74021829
22KIT1.73305255
23BMX1.69822912
24RPS6KA41.67846425
25CDK61.64661273
26SIK31.63944484
27TYK21.63323930
28PAK41.60759377
29ACVR1B1.60477322
30PDGFRA1.57306955
31MAP3K21.56782955
32MAP4K11.52788024
33PTK61.51061577
34STK101.49192134
35PIM11.47137401
36KSR11.44289398
37KSR21.43418649
38TYRO31.42148238
39PDGFRB1.41485436
40CSK1.34513629
41NEK91.34189789
42LMTK21.33959693
43DDR21.33046769
44PIM21.31571408
45ERBB31.29268118
46MATK1.27617366
47CAMK1G1.27293908
48NLK1.22745881
49BLK1.19359586
50LRRK21.18853247
51LATS11.17404727
52JAK31.16862839
53CHUK1.16458347
54MET1.13963450
55PBK1.11410010
56WNK11.10016195
57MARK31.08658120
58MST41.07967159
59DYRK31.07651840
60CDC42BPA1.07289180
61IRAK31.06672634
62FGFR30.96904770
63STK40.96207953
64STK38L0.94666829
65JAK10.94229944
66ABL20.93332125
67ZAP700.91862327
68IKBKB0.88625086
69BRD40.87888958
70EPHB20.86681885
71PTK2B0.86450000
72TEC0.85727334
73SGK30.84062669
74TRPM70.83385077
75EGFR0.82358151
76FGR0.82139942
77IKBKE0.82043930
78NEK20.80652115
79IRAK10.80599987
80TAOK30.80408829
81MAP3K50.78057398
82PAK20.77977228
83PRKG20.77026590
84BCR0.76402794
85EPHB10.75277769
86FER0.74466459
87HCK0.74338781
88SGK20.72012318
89MAP3K100.71903574
90FGFR10.71110081
91ALK0.70328918
92MAP3K60.69821669
93FES0.67786971
94EPHA20.67507768
95STK240.67312568
96FLT30.67158357
97MKNK10.66449477
98MOS0.66419911
99ERBB40.65115433
100CDK90.63961780
101CDK40.63870956
102MST1R0.63543064
103ABL10.63516979
104PTK20.63368983
105DMPK0.62336433
106BMPR20.61798156
107MAP3K80.61515322
108RET0.61208855
109CAMK1D0.59534235
110PRPF4B0.59496041
111JAK20.58054858
112IRAK20.56475970
113MAP3K110.54191684
114GRK70.52654807
115PIK3CG0.50937387
116BRSK20.50215931
117NUAK10.49956784
118STK380.49484513
119TAOK20.49311483
120MELK0.49064184
121CSF1R0.49051667
122MTOR0.48493708
123LCK0.48123359
124RPS6KA60.47815292
125GSK3A0.47544136
126EPHA30.47131146
127ERBB20.44932051
128TXK0.44281024
129TNIK0.43434760
130MAP3K130.42490937
131LYN0.41688330
132AKT20.41493788
133TAOK10.40910308
134FGFR40.39904858
135SIK10.39718418
136MAP3K10.39671887
137INSR0.38855474
138TAF10.37708402
139BTK0.37000146
140RAF10.36344085
141PDPK10.36094193

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.68006784
2Malaria_Homo sapiens_hsa051442.08575268
3Osteoclast differentiation_Homo sapiens_hsa043802.03853945
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01266857
5Staphylococcus aureus infection_Homo sapiens_hsa051502.00067566
6Toll-like receptor signaling pathway_Homo sapiens_hsa046201.95139706
7Legionellosis_Homo sapiens_hsa051341.92232163
8TNF signaling pathway_Homo sapiens_hsa046681.86195245
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.85574584
10Pertussis_Homo sapiens_hsa051331.82707838
11AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.79694494
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.77624103
13Tuberculosis_Homo sapiens_hsa051521.70047467
14Toxoplasmosis_Homo sapiens_hsa051451.69023865
15Chronic myeloid leukemia_Homo sapiens_hsa052201.62851070
16Measles_Homo sapiens_hsa051621.60510631
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.59291060
18ECM-receptor interaction_Homo sapiens_hsa045121.58621658
19Small cell lung cancer_Homo sapiens_hsa052221.57941380
20Adherens junction_Homo sapiens_hsa045201.55736655
21Hematopoietic cell lineage_Homo sapiens_hsa046401.55391185
22Shigellosis_Homo sapiens_hsa051311.54224317
23Amoebiasis_Homo sapiens_hsa051461.53787418
24Salmonella infection_Homo sapiens_hsa051321.53693750
25Acute myeloid leukemia_Homo sapiens_hsa052211.50952810
26Viral myocarditis_Homo sapiens_hsa054161.47346709
27Influenza A_Homo sapiens_hsa051641.46636210
28Proteoglycans in cancer_Homo sapiens_hsa052051.42936257
29Apoptosis_Homo sapiens_hsa042101.41835387
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40743066
31Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.40481545
32Graft-versus-host disease_Homo sapiens_hsa053321.38376067
33Focal adhesion_Homo sapiens_hsa045101.38276192
34B cell receptor signaling pathway_Homo sapiens_hsa046621.36799612
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35333290
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34892301
37MicroRNAs in cancer_Homo sapiens_hsa052061.34811366
38Herpes simplex infection_Homo sapiens_hsa051681.34645388
39Hepatitis B_Homo sapiens_hsa051611.34186738
40Platelet activation_Homo sapiens_hsa046111.32449538
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23755376
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18517980
43Pancreatic cancer_Homo sapiens_hsa052121.17483621
44Phagosome_Homo sapiens_hsa041451.16799873
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16209604
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.15881310
47Rheumatoid arthritis_Homo sapiens_hsa053231.15437540
48TGF-beta signaling pathway_Homo sapiens_hsa043501.11414203
49Phospholipase D signaling pathway_Homo sapiens_hsa040721.10866076
50Thyroid cancer_Homo sapiens_hsa052161.08904931
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08835334
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07001032
53Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05517655
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05182557
55Hepatitis C_Homo sapiens_hsa051601.02680946
56ErbB signaling pathway_Homo sapiens_hsa040121.00695821
57Antigen processing and presentation_Homo sapiens_hsa046120.99161404
58Complement and coagulation cascades_Homo sapiens_hsa046100.97623754
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.95494717
60Dorso-ventral axis formation_Homo sapiens_hsa043200.95230085
61Chemokine signaling pathway_Homo sapiens_hsa040620.95137622
62Endocytosis_Homo sapiens_hsa041440.93876050
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93005937
64Prostate cancer_Homo sapiens_hsa052150.89621633
65HTLV-I infection_Homo sapiens_hsa051660.88137745
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87873784
67Colorectal cancer_Homo sapiens_hsa052100.86616512
68Asthma_Homo sapiens_hsa053100.86528075
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86093108
70Choline metabolism in cancer_Homo sapiens_hsa052310.84509073
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84435804
72African trypanosomiasis_Homo sapiens_hsa051430.84234793
73HIF-1 signaling pathway_Homo sapiens_hsa040660.83028967
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.82435481
75FoxO signaling pathway_Homo sapiens_hsa040680.81380782
76Lysosome_Homo sapiens_hsa041420.81235988
77Renal cell carcinoma_Homo sapiens_hsa052110.81122558
78VEGF signaling pathway_Homo sapiens_hsa043700.80809281
79Bladder cancer_Homo sapiens_hsa052190.79444533
80PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78882356
81p53 signaling pathway_Homo sapiens_hsa041150.78204636
82Ras signaling pathway_Homo sapiens_hsa040140.77552832
83Rap1 signaling pathway_Homo sapiens_hsa040150.76611285
84Endometrial cancer_Homo sapiens_hsa052130.75940170
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75720366
86Gap junction_Homo sapiens_hsa045400.75338242
87Pathways in cancer_Homo sapiens_hsa052000.74600686
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.71572144
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71357786
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70670395
91Prolactin signaling pathway_Homo sapiens_hsa049170.69558370
92Viral carcinogenesis_Homo sapiens_hsa052030.69533347
93Insulin signaling pathway_Homo sapiens_hsa049100.67922806
94Allograft rejection_Homo sapiens_hsa053300.66993190
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66685256
96Melanoma_Homo sapiens_hsa052180.66398884
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.65916167
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65861238
99Notch signaling pathway_Homo sapiens_hsa043300.63525267
100Prion diseases_Homo sapiens_hsa050200.63326281
101Insulin resistance_Homo sapiens_hsa049310.63181458
102Hippo signaling pathway_Homo sapiens_hsa043900.63143217
103MAPK signaling pathway_Homo sapiens_hsa040100.61705709
104T cell receptor signaling pathway_Homo sapiens_hsa046600.61414128
105Glioma_Homo sapiens_hsa052140.61331690
106Epstein-Barr virus infection_Homo sapiens_hsa051690.60551596
107Long-term depression_Homo sapiens_hsa047300.60309420
108Estrogen signaling pathway_Homo sapiens_hsa049150.59827660
109GnRH signaling pathway_Homo sapiens_hsa049120.59092447
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55685103
111Nitrogen metabolism_Homo sapiens_hsa009100.54702899
112mTOR signaling pathway_Homo sapiens_hsa041500.53147280
113Non-small cell lung cancer_Homo sapiens_hsa052230.52659796
114Type II diabetes mellitus_Homo sapiens_hsa049300.52294991
115Cell cycle_Homo sapiens_hsa041100.52021097
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51959255
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48431991
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.47208682
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.47096960

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