PTP4A2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1inner mitochondrial membrane organization (GO:0007007)4.98587556
2respiratory chain complex IV assembly (GO:0008535)4.93403821
3cytochrome complex assembly (GO:0017004)4.85552267
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.70135040
5protein complex biogenesis (GO:0070271)4.61211149
6positive regulation of glycoprotein biosynthetic process (GO:0010560)4.50163449
7cellular ketone body metabolic process (GO:0046950)4.44572970
8misfolded or incompletely synthesized protein catabolic process (GO:0006515)4.44017443
9positive regulation of actin filament depolymerization (GO:0030836)4.38587081
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.30056390
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.27955078
12ATP synthesis coupled proton transport (GO:0015986)4.27955078
13inositol phosphate dephosphorylation (GO:0046855)4.24620841
14phosphorylated carbohydrate dephosphorylation (GO:0046838)4.24620841
15protein import into peroxisome matrix (GO:0016558)4.20629164
16mitochondrial respiratory chain complex assembly (GO:0033108)4.17317002
17artery smooth muscle contraction (GO:0014824)4.12698708
18ketone body metabolic process (GO:1902224)4.05286704
19inositol phosphate catabolic process (GO:0071545)4.04082951
20positive regulation of glycoprotein metabolic process (GO:1903020)4.02253761
21regulation of hexokinase activity (GO:1903299)3.99393504
22regulation of glucokinase activity (GO:0033131)3.99393504
23regulation of mitochondrial translation (GO:0070129)3.84114020
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.74824602
25behavioral response to nicotine (GO:0035095)3.72393222
26intracellular protein transmembrane import (GO:0044743)3.70403902
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.69058137
28NADH dehydrogenase complex assembly (GO:0010257)3.69058137
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.69058137
30platelet dense granule organization (GO:0060155)3.61448383
31tonic smooth muscle contraction (GO:0014820)3.40350816
32regulation of cilium movement (GO:0003352)3.37354891
33very-low-density lipoprotein particle assembly (GO:0034379)3.34769936
34electron transport chain (GO:0022900)3.33786509
35autophagic vacuole fusion (GO:0000046)3.31418961
36respiratory electron transport chain (GO:0022904)3.27134211
37amino-acid betaine metabolic process (GO:0006577)3.19084863
38indolalkylamine metabolic process (GO:0006586)3.18359829
39insulin secretion (GO:0030073)3.16037274
40interkinetic nuclear migration (GO:0022027)3.14899452
41magnesium ion transport (GO:0015693)3.14782481
42polyol catabolic process (GO:0046174)3.14697876
43positive regulation of cardiac muscle hypertrophy (GO:0010613)3.09085650
44positive regulation of muscle hypertrophy (GO:0014742)3.09085650
45energy homeostasis (GO:0097009)3.08671209
46glycerophospholipid catabolic process (GO:0046475)3.07377250
47vascular smooth muscle contraction (GO:0014829)3.05739732
48detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.03569268
49organelle membrane fusion (GO:0090174)3.03220849
50inner ear receptor cell development (GO:0060119)3.02066795
51serotonin metabolic process (GO:0042428)3.00413829
52epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.98940276
53erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.98112371
54L-phenylalanine catabolic process (GO:0006559)2.98112371
55hydrogen ion transmembrane transport (GO:1902600)2.96292118
56urate metabolic process (GO:0046415)2.95411394
57ovulation cycle (GO:0042698)2.95276928
58L-phenylalanine metabolic process (GO:0006558)2.94178212
59erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.94178212
60kidney morphogenesis (GO:0060993)2.92310844
61proteasome assembly (GO:0043248)2.90380714
62signal peptide processing (GO:0006465)2.88454812
63purine nucleoside triphosphate biosynthetic process (GO:0009145)2.84276590
64high-density lipoprotein particle remodeling (GO:0034375)2.83656204
65regulation of protein glycosylation (GO:0060049)2.83280814
66adenosine metabolic process (GO:0046085)2.82842655
67endocrine pancreas development (GO:0031018)2.81538911
68aggressive behavior (GO:0002118)2.79598983
69proton transport (GO:0015992)2.79178608
70cell wall macromolecule catabolic process (GO:0016998)2.78891474
71piRNA metabolic process (GO:0034587)2.78091513
72hydrogen transport (GO:0006818)2.77680328
73epithelial cell fate commitment (GO:0072148)2.76769854
74negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.75663395
75DNA deamination (GO:0045006)2.75588410
76protein targeting to peroxisome (GO:0006625)2.73534930
77establishment of protein localization to peroxisome (GO:0072663)2.73534930
78protein localization to peroxisome (GO:0072662)2.73534930
79protein neddylation (GO:0045116)2.72158257
80ATP biosynthetic process (GO:0006754)2.71278605
81intracellular protein transmembrane transport (GO:0065002)2.70484384
82phasic smooth muscle contraction (GO:0014821)2.70453353
83carnitine metabolic process (GO:0009437)2.68376728
84indole-containing compound metabolic process (GO:0042430)2.67712189
85heart process (GO:0003015)2.64948334
86heart contraction (GO:0060047)2.64948334
87regulation of cytokine secretion involved in immune response (GO:0002739)2.64698107
88primary amino compound metabolic process (GO:1901160)2.64308286
89protein peptidyl-prolyl isomerization (GO:0000413)2.61983447
90aromatic amino acid family catabolic process (GO:0009074)2.61365699
91reverse cholesterol transport (GO:0043691)2.60556225
92thyroid hormone metabolic process (GO:0042403)2.60293598
93detection of light stimulus involved in sensory perception (GO:0050962)2.59437114
94detection of light stimulus involved in visual perception (GO:0050908)2.59437114
95nitric oxide mediated signal transduction (GO:0007263)2.58360966
96opioid receptor signaling pathway (GO:0038003)2.57757514
97negative regulation of protein oligomerization (GO:0032460)2.57578087
98keratinocyte development (GO:0003334)2.56755955
99nephron epithelium morphogenesis (GO:0072088)2.55040410
100nephron tubule morphogenesis (GO:0072078)2.55040410

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.52885275
2VDR_22108803_ChIP-Seq_LS180_Human3.31906857
3ZNF274_21170338_ChIP-Seq_K562_Hela3.11087553
4FLI1_27457419_Chip-Seq_LIVER_Mouse2.72808463
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.66988319
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.49888638
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38258843
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31427521
9FUS_26573619_Chip-Seq_HEK293_Human2.24574794
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.20638990
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18648555
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16365036
13ER_23166858_ChIP-Seq_MCF-7_Human2.14889519
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.14173355
15PCGF2_27294783_Chip-Seq_ESCs_Mouse1.98866000
16SALL1_21062744_ChIP-ChIP_HESCs_Human1.98041843
17EWS_26573619_Chip-Seq_HEK293_Human1.93475939
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93165412
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92270672
20EGR1_23403033_ChIP-Seq_LIVER_Mouse1.92090888
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82557659
22GBX2_23144817_ChIP-Seq_PC3_Human1.78561809
23ELK1_19687146_ChIP-ChIP_HELA_Human1.78158838
24EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.76945059
25P300_19829295_ChIP-Seq_ESCs_Human1.76233237
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.74470600
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.69585965
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68343102
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66225090
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64615907
31CBP_20019798_ChIP-Seq_JUKART_Human1.64615907
32SOX2_19829295_ChIP-Seq_ESCs_Human1.63828441
33NANOG_19829295_ChIP-Seq_ESCs_Human1.63828441
34TP53_22573176_ChIP-Seq_HFKS_Human1.61680351
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58887009
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52663469
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50892298
38TCF4_22108803_ChIP-Seq_LS180_Human1.50261670
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.48116870
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.48116870
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.47837004
42VDR_23849224_ChIP-Seq_CD4+_Human1.47693135
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43858654
44P53_22387025_ChIP-Seq_ESCs_Mouse1.42094329
45BCAT_22108803_ChIP-Seq_LS180_Human1.40176872
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.35453186
47CRX_20693478_ChIP-Seq_RETINA_Mouse1.34806187
48EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34672564
49STAT3_23295773_ChIP-Seq_U87_Human1.34412275
50SMAD4_21799915_ChIP-Seq_A2780_Human1.33903487
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33415830
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31816955
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30773429
54TAF15_26573619_Chip-Seq_HEK293_Human1.30458025
55TCF4_23295773_ChIP-Seq_U87_Human1.29292377
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.29061564
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28907156
58RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28118073
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26801212
60AR_25329375_ChIP-Seq_VCAP_Human1.26447013
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24886778
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24550416
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22720181
64NCOR_22424771_ChIP-Seq_293T_Human1.21850273
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.21777500
66STAT3_18555785_Chip-Seq_ESCs_Mouse1.21179399
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20922181
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20537585
69OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20052246
70OCT4_18555785_Chip-Seq_ESCs_Mouse1.19203805
71MYC_18940864_ChIP-ChIP_HL60_Human1.18898480
72ETS1_20019798_ChIP-Seq_JURKAT_Human1.18383515
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18011072
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16565038
75CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16372491
76EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14678446
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14668888
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14563753
79IGF1R_20145208_ChIP-Seq_DFB_Human1.14331295
80P300_18555785_Chip-Seq_ESCs_Mouse1.14058396
81SOX2_18555785_Chip-Seq_ESCs_Mouse1.12995152
82GATA3_21878914_ChIP-Seq_MCF-7_Human1.12210826
83CMYC_18555785_Chip-Seq_ESCs_Mouse1.11724857
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.11352588
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10824084
86SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10505202
87CTCF_18555785_Chip-Seq_ESCs_Mouse1.10244257
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10058817
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07280571
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05396906
91PHF8_20622853_ChIP-Seq_HELA_Human1.05133618
92RNF2_27304074_Chip-Seq_NSC_Mouse1.04869030
93REST_21632747_ChIP-Seq_MESCs_Mouse1.04582229
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04284265
95CDX2_22108803_ChIP-Seq_LS180_Human1.04180010
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03830954
97HTT_18923047_ChIP-ChIP_STHdh_Human1.03615697
98ZFX_18555785_Chip-Seq_ESCs_Mouse1.03365637
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03037471
100ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01558354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.29909915
2MP0002938_white_spotting3.74642771
3MP0003787_abnormal_imprinting3.33213502
4MP0004147_increased_porphyrin_level3.28774331
5MP0003011_delayed_dark_adaptation2.88685876
6MP0002837_dystrophic_cardiac_calcinosis2.57982373
7MP0002254_reproductive_system_inflammat2.46420998
8MP0003806_abnormal_nucleotide_metabolis2.43030863
9MP0000372_irregular_coat_pigmentation2.41871388
10MP0003136_yellow_coat_color2.37411024
11MP0005075_abnormal_melanosome_morpholog2.37263029
12MP0000647_abnormal_sebaceous_gland2.36810420
13MP0005187_abnormal_penis_morphology2.32986244
14MP0005645_abnormal_hypothalamus_physiol2.32066549
15MP0006072_abnormal_retinal_apoptosis2.21795433
16MP0005174_abnormal_tail_pigmentation2.16814204
17MP0004043_abnormal_pH_regulation2.08330562
18MP0002139_abnormal_hepatobiliary_system2.06791361
19MP0002909_abnormal_adrenal_gland2.03689248
20MP0008877_abnormal_DNA_methylation2.03177112
21MP0000013_abnormal_adipose_tissue1.99767162
22MP0005379_endocrine/exocrine_gland_phen1.98182853
23MP0008004_abnormal_stomach_pH1.97428835
24MP0002163_abnormal_gland_morphology1.96087681
25MP0005551_abnormal_eye_electrophysiolog1.89018129
26MP0005646_abnormal_pituitary_gland1.81287909
27MP0000427_abnormal_hair_cycle1.78078295
28MP0008995_early_reproductive_senescence1.73997430
29MP0009840_abnormal_foam_cell1.71169034
30MP0002876_abnormal_thyroid_physiology1.70538684
31MP0003195_calcinosis1.65338746
32MP0003315_abnormal_perineum_morphology1.64096926
33MP0005253_abnormal_eye_physiology1.62234355
34MP0002638_abnormal_pupillary_reflex1.57655091
35MP0004381_abnormal_hair_follicle1.53935829
36MP0001968_abnormal_touch/_nociception1.53503955
37MP0010329_abnormal_lipoprotein_level1.51648694
38MP0002095_abnormal_skin_pigmentation1.45948130
39MP0005084_abnormal_gallbladder_morpholo1.42495238
40MP0006054_spinal_hemorrhage1.39600248
41MP0002138_abnormal_hepatobiliary_system1.35850373
42MP0004885_abnormal_endolymph1.35354122
43MP0001986_abnormal_taste_sensitivity1.33542182
44MP0000639_abnormal_adrenal_gland1.33531960
45MP0002557_abnormal_social/conspecific_i1.29732842
46MP0003122_maternal_imprinting1.26768076
47MP0003121_genomic_imprinting1.26144149
48MP0009046_muscle_twitch1.25153068
49MP0005332_abnormal_amino_acid1.25138312
50MP0005365_abnormal_bile_salt1.24307730
51MP0000566_synostosis1.23989642
52MP0003283_abnormal_digestive_organ1.23531105
53MP0003186_abnormal_redox_activity1.22647118
54MP0005636_abnormal_mineral_homeostasis1.22024684
55MP0008875_abnormal_xenobiotic_pharmacok1.21817661
56MP0002693_abnormal_pancreas_physiology1.18379628
57MP0003786_premature_aging1.15770923
58MP0002751_abnormal_autonomic_nervous1.14529945
59MP0001944_abnormal_pancreas_morphology1.12042895
60MP0002736_abnormal_nociception_after1.11746182
61MP0001905_abnormal_dopamine_level1.11123790
62MP0005220_abnormal_exocrine_pancreas1.08150477
63MP0001485_abnormal_pinna_reflex1.07381279
64MP0004133_heterotaxia1.05711555
65MP0005310_abnormal_salivary_gland1.05148021
66MP0008872_abnormal_physiological_respon1.02117745
67MP0009745_abnormal_behavioral_response0.99431747
68MP0004142_abnormal_muscle_tone0.94876248
69MP0002928_abnormal_bile_duct0.91795498
70MP0004215_abnormal_myocardial_fiber0.90338685
71MP0002102_abnormal_ear_morphology0.89858894
72MP0001756_abnormal_urination0.88086426
73MP0002272_abnormal_nervous_system0.87410119
74MP0003718_maternal_effect0.85859912
75MP0001984_abnormal_olfaction0.85348855
76MP0001919_abnormal_reproductive_system0.84464818
77MP0006036_abnormal_mitochondrial_physio0.81640223
78MP0005389_reproductive_system_phenotype0.81431468
79MP0000015_abnormal_ear_pigmentation0.80608294
80MP0001873_stomach_inflammation0.80503744
81MP0001324_abnormal_eye_pigmentation0.79972749
82MP0003868_abnormal_feces_composition0.79289870
83MP0002277_abnormal_respiratory_mucosa0.77601236
84MP0003045_fibrosis0.76640127
85MP0002160_abnormal_reproductive_system0.76121498
86MP0001970_abnormal_pain_threshold0.74358970
87MP0005408_hypopigmentation0.73202295
88MP0003953_abnormal_hormone_level0.72174121
89MP0003880_abnormal_central_pattern0.71582474
90MP0010386_abnormal_urinary_bladder0.71083650
91MP0002078_abnormal_glucose_homeostasis0.70834438
92MP0004019_abnormal_vitamin_homeostasis0.70744618
93MP0006035_abnormal_mitochondrial_morpho0.70338888
94MP0002229_neurodegeneration0.69208997
95MP0003123_paternal_imprinting0.67406409
96MP0001243_abnormal_dermal_layer0.66958410
97MP0005535_abnormal_body_temperature0.61632716
98MP0004924_abnormal_behavior0.59699536
99MP0005386_behavior/neurological_phenoty0.59699536
100MP0001765_abnormal_ion_homeostasis0.59349996

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)4.55813949
2Acute necrotizing encephalopathy (HP:0006965)4.10061010
3Type II lissencephaly (HP:0007260)3.87879228
4Progressive macrocephaly (HP:0004481)3.74034519
5Acute encephalopathy (HP:0006846)3.58516554
6Mitochondrial inheritance (HP:0001427)3.53307064
7Abnormal mitochondria in muscle tissue (HP:0008316)3.45860679
8Congenital, generalized hypertrichosis (HP:0004540)3.45467375
9Increased CSF lactate (HP:0002490)3.43842782
10Congenital stationary night blindness (HP:0007642)3.32267303
11Pancreatic cysts (HP:0001737)3.09530161
12Concave nail (HP:0001598)2.80992470
13Molar tooth sign on MRI (HP:0002419)2.76893532
14Abnormality of midbrain morphology (HP:0002418)2.76893532
15Dry hair (HP:0011359)2.74541789
16Pancreatic fibrosis (HP:0100732)2.70413308
17Cerebellar dysplasia (HP:0007033)2.69431123
18Chronic hepatic failure (HP:0100626)2.68725487
19Increased hepatocellular lipid droplets (HP:0006565)2.64683895
20Abnormality of the renal cortex (HP:0011035)2.63519426
21Neuroendocrine neoplasm (HP:0100634)2.63082724
22Hepatocellular necrosis (HP:0001404)2.57077260
23Cerebral edema (HP:0002181)2.56953471
24Patchy hypopigmentation of hair (HP:0011365)2.49064919
25Hepatic necrosis (HP:0002605)2.48226711
26Neoplasm of the adrenal cortex (HP:0100641)2.44010139
27Lipid accumulation in hepatocytes (HP:0006561)2.39620195
28Pheochromocytoma (HP:0002666)2.38405735
29Neoplasm of the adrenal gland (HP:0100631)2.34572716
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.33911516
31True hermaphroditism (HP:0010459)2.32982567
32Optic disc pallor (HP:0000543)2.30966241
33Respiratory failure (HP:0002878)2.29026824
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.26377330
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.26377330
36Delayed CNS myelination (HP:0002188)2.25409953
37White forelock (HP:0002211)2.24730058
38Abnormal pancreas size (HP:0012094)2.24672682
39Hypobetalipoproteinemia (HP:0003563)2.23019221
40Ketoacidosis (HP:0001993)2.18047315
41Renal cortical cysts (HP:0000803)2.16752625
42Type I transferrin isoform profile (HP:0003642)2.16289616
43Medial flaring of the eyebrow (HP:0010747)2.16228059
44Renal Fanconi syndrome (HP:0001994)2.15359560
45Hypoplasia of the fovea (HP:0007750)2.15184244
46Aplasia/Hypoplasia of the fovea (HP:0008060)2.15184244
47Abdominal situs inversus (HP:0003363)2.12476095
48Abnormality of abdominal situs (HP:0011620)2.12476095
49Tongue fasciculations (HP:0001308)2.12151126
50Hyperglycemia (HP:0003074)2.09629366
51Nephronophthisis (HP:0000090)2.09402648
52Lissencephaly (HP:0001339)2.07179849
53Abnormality of renal resorption (HP:0011038)2.05837856
54Abnormality of the pons (HP:0007361)2.05330732
55Vascular calcification (HP:0004934)2.05242821
56Abnormality of aromatic amino acid family metabolism (HP:0004338)2.03575211
57Lethargy (HP:0001254)2.01020560
58Abnormal rod and cone electroretinograms (HP:0008323)2.00670366
59Limb dystonia (HP:0002451)1.99654106
60Increased serum pyruvate (HP:0003542)1.98766630
61Decreased circulating renin level (HP:0003351)1.97533632
62Hypoplasia of the pons (HP:0012110)1.97165524
63Adrenal hypoplasia (HP:0000835)1.95530345
64Furrowed tongue (HP:0000221)1.93669629
65Lactic acidosis (HP:0003128)1.91190347
66Increased serum lactate (HP:0002151)1.88808083
67Poor suck (HP:0002033)1.87742133
68Limb hypertonia (HP:0002509)1.87497936
69Abnormal albumin level (HP:0012116)1.86896705
70Hypoalbuminemia (HP:0003073)1.86896705
71Brushfield spots (HP:0001088)1.85812495
72Epiphyseal stippling (HP:0010655)1.84248894
73Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83748541
74Large eyes (HP:0001090)1.83663750
75Leukodystrophy (HP:0002415)1.83241192
76Epileptic encephalopathy (HP:0200134)1.82958187
77Abnormality of urine glucose concentration (HP:0011016)1.81835542
78Glycosuria (HP:0003076)1.81835542
79Cystic liver disease (HP:0006706)1.80579683
80Prolonged QT interval (HP:0001657)1.80541041
81Abnormal protein N-linked glycosylation (HP:0012347)1.78661635
82Abnormal protein glycosylation (HP:0012346)1.78661635
83Abnormal glycosylation (HP:0012345)1.78661635
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78661635
85Aplasia/Hypoplasia of the spleen (HP:0010451)1.78620957
86Abnormality of the renal medulla (HP:0100957)1.77996928
87Abnormality of glycolysis (HP:0004366)1.76608472
88Intestinal atresia (HP:0011100)1.76415573
89Abnormality of aspartate family amino acid metabolism (HP:0010899)1.73305012
90Anhidrosis (HP:0000970)1.73034922
91Asplenia (HP:0001746)1.72415867
92Hypokinesia (HP:0002375)1.72014618
93Progressive inability to walk (HP:0002505)1.70948250
94Hypoglycemic coma (HP:0001325)1.70451882
95Hypolipoproteinemia (HP:0010981)1.69365421
96Sclerocornea (HP:0000647)1.67210755
97Hyperalaninemia (HP:0003348)1.67040658
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67040658
99Abnormality of alanine metabolism (HP:0010916)1.67040658
100Dialeptic seizures (HP:0011146)1.66637993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.99597793
2EIF2AK33.00004266
3TLK12.90079510
4OXSR12.87991244
5GRK12.64281094
6ADRBK22.56152136
7MAP3K122.54592637
8PAK32.40004003
9WNK42.38555996
10NEK92.19116382
11STK392.17466494
12EIF2AK11.80859061
13PHKG11.75765718
14PHKG21.75765718
15TXK1.73251202
16MST41.70170160
17PLK21.68410235
18DAPK21.67967365
19STK38L1.64155939
20ZAK1.57876502
21MKNK21.52974825
22WNK31.52413516
23MAP2K61.46934659
24NEK11.46607963
25PRKCE1.43815549
26BMPR1B1.41845929
27NME11.41804500
28PINK11.39423053
29MAPK131.36681244
30CASK1.31565433
31FGFR21.28519883
32NUAK11.28159367
33INSRR1.22329160
34MAP3K41.18019483
35WEE11.12823581
36CSNK1G21.12486837
37PRKD31.10470462
38FER1.06185853
39ADRBK11.03794161
40MKNK11.02415947
41CDK191.02393942
42CCNB10.99552138
43MINK10.98553833
44PRKCI0.97774800
45PTK2B0.96949378
46PNCK0.92002839
47PLK30.90753805
48UHMK10.89570399
49PRKCG0.84241562
50TIE10.83996443
51MYLK0.83316717
52CSNK1G30.82375011
53LIMK10.80497333
54ERBB30.74535006
55MAP3K60.74380925
56EPHA40.72971476
57VRK20.71555562
58MAP4K20.67008528
59ACVR1B0.64273946
60STK30.63225951
61STK240.62020039
62CSNK1G10.61227596
63TSSK60.59714276
64CDK30.56685368
65FGFR10.55154426
66TGFBR10.53878225
67WNK10.52885656
68DAPK10.52745799
69BUB10.52328444
70CAMK2A0.51932709
71CAMKK20.50749838
72MAP2K40.49149276
73PDK20.49127712
74STK160.48032533
75EIF2AK20.47435106
76OBSCN0.47313969
77BRSK20.46603477
78CAMK2D0.44944318
79DAPK30.42017901
80MAPKAPK30.40146374
81ROCK10.38123270
82PRKCA0.37979971
83PRKACA0.35820862
84PRKAA10.35273552
85ITK0.35150478
86ILK0.34606640
87KIT0.33593149
88IKBKB0.33213992
89PRKACB0.31894541
90BCR0.30526440
91PRKG10.30323794
92FLT30.30165108
93VRK10.28884327
94IGF1R0.28727906
95ERBB20.28319144
96PRKCQ0.27945032
97MAP3K50.27678552
98MAP2K10.27106642
99CAMK40.25045517
100TEC0.24425468

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.95999323
2Protein export_Homo sapiens_hsa030603.49338032
3Oxidative phosphorylation_Homo sapiens_hsa001903.38371125
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.17453585
5Parkinsons disease_Homo sapiens_hsa050122.55260638
6Butanoate metabolism_Homo sapiens_hsa006502.35086649
7Proteasome_Homo sapiens_hsa030502.33657066
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32060485
9Propanoate metabolism_Homo sapiens_hsa006402.22679238
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.97668159
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89764445
12Tryptophan metabolism_Homo sapiens_hsa003801.88761491
13Sulfur metabolism_Homo sapiens_hsa009201.74575071
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73644475
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72530918
16Peroxisome_Homo sapiens_hsa041461.71242844
17Alzheimers disease_Homo sapiens_hsa050101.63953579
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.63789559
19Type I diabetes mellitus_Homo sapiens_hsa049401.63773649
20Nitrogen metabolism_Homo sapiens_hsa009101.60679988
21Huntingtons disease_Homo sapiens_hsa050161.58972092
22Folate biosynthesis_Homo sapiens_hsa007901.55359948
23Phototransduction_Homo sapiens_hsa047441.48986209
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.47107971
25RNA polymerase_Homo sapiens_hsa030201.45016861
26Cardiac muscle contraction_Homo sapiens_hsa042601.38201191
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36617172
28Selenocompound metabolism_Homo sapiens_hsa004501.34130692
29beta-Alanine metabolism_Homo sapiens_hsa004101.28056360
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.24990842
31Asthma_Homo sapiens_hsa053101.23266857
32Steroid biosynthesis_Homo sapiens_hsa001001.21763321
33Fatty acid elongation_Homo sapiens_hsa000621.19062981
34Fatty acid degradation_Homo sapiens_hsa000711.15792713
35Other glycan degradation_Homo sapiens_hsa005111.10392935
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08174555
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07238875
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06109569
39Fatty acid metabolism_Homo sapiens_hsa012121.05635775
40Serotonergic synapse_Homo sapiens_hsa047261.05076781
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03956238
42Linoleic acid metabolism_Homo sapiens_hsa005911.03870733
43Caffeine metabolism_Homo sapiens_hsa002320.99795337
44Pyruvate metabolism_Homo sapiens_hsa006200.97071934
45Insulin secretion_Homo sapiens_hsa049110.95501592
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.92331484
47Chemical carcinogenesis_Homo sapiens_hsa052040.92328659
48Vitamin B6 metabolism_Homo sapiens_hsa007500.91761010
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91533248
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91295854
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89096751
52GABAergic synapse_Homo sapiens_hsa047270.88373066
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87076893
54Circadian rhythm_Homo sapiens_hsa047100.86298310
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82910866
56Retinol metabolism_Homo sapiens_hsa008300.80551322
57Glutathione metabolism_Homo sapiens_hsa004800.78642533
58Homologous recombination_Homo sapiens_hsa034400.74346220
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73663226
60Metabolic pathways_Homo sapiens_hsa011000.73071883
61Fatty acid biosynthesis_Homo sapiens_hsa000610.72974749
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71727152
63Morphine addiction_Homo sapiens_hsa050320.69927296
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.67138993
65Fat digestion and absorption_Homo sapiens_hsa049750.65998985
66Collecting duct acid secretion_Homo sapiens_hsa049660.65777098
67Regulation of autophagy_Homo sapiens_hsa041400.62756095
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62634555
69Allograft rejection_Homo sapiens_hsa053300.62132730
70Autoimmune thyroid disease_Homo sapiens_hsa053200.61133961
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60747631
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60687956
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59161140
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58662152
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58157374
76RNA degradation_Homo sapiens_hsa030180.57147415
77Tyrosine metabolism_Homo sapiens_hsa003500.56125672
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55249746
79Nicotine addiction_Homo sapiens_hsa050330.54022642
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53752520
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53302627
82Dopaminergic synapse_Homo sapiens_hsa047280.51059031
83Pyrimidine metabolism_Homo sapiens_hsa002400.51050786
84Purine metabolism_Homo sapiens_hsa002300.49907670
85Graft-versus-host disease_Homo sapiens_hsa053320.49469299
86Circadian entrainment_Homo sapiens_hsa047130.49048186
87Mineral absorption_Homo sapiens_hsa049780.46762373
88Histidine metabolism_Homo sapiens_hsa003400.45500912
89Arachidonic acid metabolism_Homo sapiens_hsa005900.44811562
90Sphingolipid metabolism_Homo sapiens_hsa006000.43251777
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42770043
92Non-homologous end-joining_Homo sapiens_hsa034500.42499105
93PPAR signaling pathway_Homo sapiens_hsa033200.39980517
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39508332
95Arginine biosynthesis_Homo sapiens_hsa002200.39041206
96Rheumatoid arthritis_Homo sapiens_hsa053230.38627761
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37732086
98Fanconi anemia pathway_Homo sapiens_hsa034600.36665986
99Taste transduction_Homo sapiens_hsa047420.36203823
100Dorso-ventral axis formation_Homo sapiens_hsa043200.35880116

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