PTOV1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell junction maintenance (GO:0045217)4.26582123
2semaphorin-plexin signaling pathway (GO:0071526)4.03098650
3planar cell polarity pathway involved in neural tube closure (GO:0090179)3.99554379
4gonadal mesoderm development (GO:0007506)3.90289968
5layer formation in cerebral cortex (GO:0021819)3.90100208
6cerebellar granule cell differentiation (GO:0021707)3.81714789
7peptidyl-arginine omega-N-methylation (GO:0035247)3.80724225
8regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.78167289
9cell migration in hindbrain (GO:0021535)3.72404111
10positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.66981861
11paraxial mesoderm development (GO:0048339)3.65453108
12embryonic foregut morphogenesis (GO:0048617)3.61988852
13protein retention in ER lumen (GO:0006621)3.54404622
14polarized epithelial cell differentiation (GO:0030859)3.54192081
15peptidyl-arginine methylation (GO:0018216)3.48226702
16peptidyl-arginine N-methylation (GO:0035246)3.48226702
17establishment of mitochondrion localization (GO:0051654)3.48081352
18negative regulation of microtubule polymerization (GO:0031115)3.41705711
19cell communication by electrical coupling (GO:0010644)3.40876353
20mitochondrion transport along microtubule (GO:0047497)3.40239454
21establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.40239454
22regulation of ARF GTPase activity (GO:0032312)3.37335662
23cell junction maintenance (GO:0034331)3.29081159
24establishment of apical/basal cell polarity (GO:0035089)3.22215644
25glial cell proliferation (GO:0014009)3.20643057
26neuron projection extension involved in neuron projection guidance (GO:1902284)3.20476382
27axon extension involved in axon guidance (GO:0048846)3.20476382
28neuronal ion channel clustering (GO:0045161)3.20176999
29regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.15844459
30negative regulation of catenin import into nucleus (GO:0035414)3.15768506
31synaptic vesicle exocytosis (GO:0016079)3.12968893
32peptidyl-lysine dimethylation (GO:0018027)3.11880402
33regulation of synapse maturation (GO:0090128)3.07256893
34histone H4 deacetylation (GO:0070933)3.04198891
35establishment of monopolar cell polarity (GO:0061162)3.02217077
36establishment or maintenance of monopolar cell polarity (GO:0061339)3.02217077
37negative regulation of cell size (GO:0045792)3.01189156
38glutamate secretion (GO:0014047)3.01128413
39maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.00761845
40establishment of nucleus localization (GO:0040023)3.00228953
41synaptic vesicle maturation (GO:0016188)2.99424948
42proximal/distal pattern formation (GO:0009954)2.99138453
43dopamine receptor signaling pathway (GO:0007212)2.98423809
44positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.98111373
45histone arginine methylation (GO:0034969)2.97808203
46positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.97393559
47postsynaptic membrane organization (GO:0001941)2.97369202
48cranial nerve morphogenesis (GO:0021602)2.96817674
49gastrulation with mouth forming second (GO:0001702)2.96064495
50cerebellar Purkinje cell layer development (GO:0021680)2.89251413
51regulation of mammary gland epithelial cell proliferation (GO:0033599)2.87871209
52pre-miRNA processing (GO:0031054)2.84680147
53positive regulation of synapse maturation (GO:0090129)2.84304093
54growth hormone secretion (GO:0030252)2.83304406
55ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.83013998
56regulation of early endosome to late endosome transport (GO:2000641)2.82980998
57protein-DNA complex disassembly (GO:0032986)2.81808829
58nucleosome disassembly (GO:0006337)2.81808829
59cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.80534276
60negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.80000615
61regulation of ARF protein signal transduction (GO:0032012)2.79293636
62regulation of NFAT protein import into nucleus (GO:0051532)2.79186913
63Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.78903469
64regulation of short-term neuronal synaptic plasticity (GO:0048172)2.75054471
65establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.73802273
66peptidyl-tyrosine autophosphorylation (GO:0038083)2.73562403
67establishment of planar polarity (GO:0001736)2.72918163
68establishment of tissue polarity (GO:0007164)2.72918163
69axonal fasciculation (GO:0007413)2.71633319
70regulation of establishment of planar polarity (GO:0090175)2.71130933
71membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.69738673
72intracellular estrogen receptor signaling pathway (GO:0030520)2.66311816
73cochlea morphogenesis (GO:0090103)2.64476592
74body morphogenesis (GO:0010171)2.63895741
75collecting duct development (GO:0072044)2.63880240
76regulation of synaptic vesicle exocytosis (GO:2000300)2.63876535
77histone H3 deacetylation (GO:0070932)2.63795140
78G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.63560159
79cardiac myofibril assembly (GO:0055003)2.63557139
80dendritic spine organization (GO:0097061)2.63427998
81dendritic spine morphogenesis (GO:0060997)2.61894935
82regulation of glycogen (starch) synthase activity (GO:2000465)2.61612209
83hippo signaling (GO:0035329)2.59779538
84epithelial cell fate commitment (GO:0072148)2.59199640
85positive regulation of gastrulation (GO:2000543)2.59024466
86positive regulation of dendrite morphogenesis (GO:0050775)2.57472455
87negative regulation of potassium ion transmembrane transport (GO:1901380)2.57333328
88activation of MAPKKK activity (GO:0000185)2.56792999
89neuromuscular process controlling balance (GO:0050885)2.56694113
90UV protection (GO:0009650)2.56355550
91non-canonical Wnt signaling pathway (GO:0035567)2.55728309
92outer ear morphogenesis (GO:0042473)2.55468076
93atrioventricular valve morphogenesis (GO:0003181)2.55405964
94adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.54474004
95maternal placenta development (GO:0001893)2.54218089
96mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.53881962
97negative regulation of erythrocyte differentiation (GO:0045647)2.53846399
98mannose metabolic process (GO:0006013)2.53721989
99apoptotic process involved in morphogenesis (GO:0060561)2.53525274
100neural tube development (GO:0021915)2.53203050
101plasma membrane repair (GO:0001778)2.51965289
102renal system development (GO:0072001)2.50640085
103negative regulation of axon extension involved in axon guidance (GO:0048843)2.50006542
104locomotory exploration behavior (GO:0035641)2.49919624
105cytoskeletal anchoring at plasma membrane (GO:0007016)2.49728184
106regulation of chromatin binding (GO:0035561)2.48190616
107convergent extension (GO:0060026)2.47288104
108pyrimidine nucleobase catabolic process (GO:0006208)2.46917508
109synaptic vesicle endocytosis (GO:0048488)2.45792041
110protein insertion into membrane (GO:0051205)2.45241617
111focal adhesion assembly (GO:0048041)2.43993319
112cell-substrate adherens junction assembly (GO:0007045)2.43993319
113regulation of axon extension involved in axon guidance (GO:0048841)2.43532960
114regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.43213603
115membrane repolarization during action potential (GO:0086011)2.43137990
116lung epithelium development (GO:0060428)2.42565998
117cerebral cortex neuron differentiation (GO:0021895)2.42440588
118spinal cord development (GO:0021510)2.42214310
119synaptic vesicle docking involved in exocytosis (GO:0016081)2.41954031
120vocalization behavior (GO:0071625)2.41115158
121neuron projection extension (GO:1990138)2.40390663
122regulation of synapse structural plasticity (GO:0051823)2.39387470
123central nervous system myelination (GO:0022010)2.39220621
124axon ensheathment in central nervous system (GO:0032291)2.39220621
125regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.38910848
126lung-associated mesenchyme development (GO:0060484)2.38497729
127negative regulation of oligodendrocyte differentiation (GO:0048715)2.37361355
128heterochromatin organization (GO:0070828)2.36669326
129skeletal muscle organ development (GO:0060538)2.36198299
130positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.35555042
131cellular component maintenance (GO:0043954)2.35067833
132establishment or maintenance of apical/basal cell polarity (GO:0035088)2.34712439
133establishment or maintenance of bipolar cell polarity (GO:0061245)2.34712439
134cardiac muscle cell proliferation (GO:0060038)2.34473328
135negative regulation of RNA splicing (GO:0033119)2.34125506
136G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.33524184
137anatomical structure regression (GO:0060033)2.32332678
138regulation of axon guidance (GO:1902667)2.31876138
139response to parathyroid hormone (GO:0071107)2.31465559
140negative regulation of axon guidance (GO:1902668)2.30814438
141regulation of neuronal synaptic plasticity (GO:0048168)2.30760127
142endocardial cushion morphogenesis (GO:0003203)2.30087957
143cellular potassium ion homeostasis (GO:0030007)2.30001718
144positive regulation of axonogenesis (GO:0050772)2.29700663
145negative regulation of glial cell proliferation (GO:0060253)2.29691071
146cardiovascular system development (GO:0072358)2.29634455
147glucocorticoid receptor signaling pathway (GO:0042921)2.29581643
148regulation of hippo signaling (GO:0035330)2.29561482
149axon extension (GO:0048675)2.29497489
150heart valve formation (GO:0003188)2.29261168
151positive regulation of RNA splicing (GO:0033120)2.28672960
152membrane repolarization (GO:0086009)2.26837489
153adherens junction assembly (GO:0034333)2.26434307
154ectodermal placode formation (GO:0060788)2.25048640
155lateral sprouting from an epithelium (GO:0060601)2.23257374
156respiratory system process (GO:0003016)2.23206834
157dorsal/ventral axis specification (GO:0009950)2.22725842
158camera-type eye morphogenesis (GO:0048593)2.21912110
159negative regulation of cytosolic calcium ion concentration (GO:0051481)2.21832203
160neuron recognition (GO:0008038)2.20733798
161sodium ion export (GO:0071436)2.20420044

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.01953885
2ZFP281_18757296_ChIP-ChIP_E14_Mouse3.14000681
3EZH2_22144423_ChIP-Seq_EOC_Human2.95393148
4ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.84574253
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.73791236
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.64436360
7ZFP281_27345836_Chip-Seq_ESCs_Mouse2.26284414
8* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.25261776
9EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.22358367
10LXR_22292898_ChIP-Seq_THP-1_Human2.15732737
11KDM2B_26808549_Chip-Seq_K562_Human2.13648107
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.09471101
13ERG_21242973_ChIP-ChIP_JURKAT_Human2.07306722
14KDM2B_26808549_Chip-Seq_DND41_Human1.91727567
15EZH2_27304074_Chip-Seq_ESCs_Mouse1.88946557
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88782659
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88569377
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88569377
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86508514
20* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.82613856
21OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.81772040
22ZNF263_19887448_ChIP-Seq_K562_Human1.77842558
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75230024
24MYC_22102868_ChIP-Seq_BL_Human1.75137909
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75048501
26* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.72738868
27TP53_20018659_ChIP-ChIP_R1E_Mouse1.72346915
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.72151693
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.68289344
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.67345014
31DNAJC2_21179169_ChIP-ChIP_NT2_Human1.67213735
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64864151
33CTCF_27219007_Chip-Seq_ERYTHROID_Human1.62065318
34TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.61310677
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60619951
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.58760582
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.58414567
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.57605669
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56823983
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.55571617
41KDM2B_26808549_Chip-Seq_JURKAT_Human1.55131924
42SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.54614869
43ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.53394683
44CREB1_26743006_Chip-Seq_LNCaP_Human1.52943125
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.52891807
46RING1B_27294783_Chip-Seq_NPCs_Mouse1.52446604
47UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.50361524
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.49419472
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46275369
50ELF1_20517297_ChIP-Seq_JURKAT_Human1.45759200
51* RARB_27405468_Chip-Seq_BRAIN_Mouse1.44573668
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44058495
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42868830
54SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.41139459
55CTCF_27219007_Chip-Seq_Bcells_Human1.38575949
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.36185128
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34222252
58BCOR_27268052_Chip-Seq_Bcells_Human1.33932102
59* TCF7_22412390_ChIP-Seq_EML_Mouse1.33919812
60P68_20966046_ChIP-Seq_HELA_Human1.32884162
61BCL6_27268052_Chip-Seq_Bcells_Human1.32264376
62PHF8_20622854_ChIP-Seq_HELA_Human1.31611196
63RACK7_27058665_Chip-Seq_MCF-7_Human1.31423446
64CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31191429
65SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.31085342
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29073236
67* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.28082327
68SA1_27219007_Chip-Seq_ERYTHROID_Human1.27789166
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.27652180
70VDR_21846776_ChIP-Seq_THP-1_Human1.27542517
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24928865
72MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24249932
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24171070
74* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24167215
75P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23909081
76SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.23225261
77CLOCK_20551151_ChIP-Seq_293T_Human1.22532792
78RARA_24833708_ChIP-Seq_LIVER_Mouse1.22489686
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22301281
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22247784
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22145842
82DROSHA_22980978_ChIP-Seq_HELA_Human1.21989821
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21780405
84ISL1_27105846_Chip-Seq_CPCs_Mouse1.21378428
85SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20954404
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19479670
87SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19242900
88TET1_21490601_ChIP-Seq_MESCs_Mouse1.18945856
89E2F1_20622854_ChIP-Seq_HELA_Human1.18737378
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18349920
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18338136
92SA1_27219007_Chip-Seq_Bcells_Human1.17486763
93NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16521926
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15959476
95RARB_24833708_ChIP-Seq_LIVER_Mouse1.15713349
96CIITA_25753668_ChIP-Seq_RAJI_Human1.14954459
97TET1_21451524_ChIP-Seq_MESCs_Mouse1.14774911
98SMC4_20622854_ChIP-Seq_HELA_Human1.13576585
99TP63_22573176_ChIP-Seq_HFKS_Human1.13463240
100* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.13455875
101ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12571302
102* MAF_26560356_Chip-Seq_TH2_Human1.12022411
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11361182
104* FOXP1_21924763_ChIP-Seq_HESCs_Human1.11105022
105OCT4_19829295_ChIP-Seq_ESCs_Human1.10601299
106TP53_22127205_ChIP-Seq_IMR90_Human1.10260553
107ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09672626
108MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.09660526
109SOX3_22085726_ChIP-Seq_NPCs_Mouse1.08764395
110NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06696303
111KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06405880
112YY1_22570637_ChIP-Seq_MALME-3M_Human1.06359675
113* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05707028
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05626905
115RUNX1_27514584_Chip-Seq_MCF-7_Human1.05050013
116POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04150280
117NANOG_21062744_ChIP-ChIP_HESCs_Human1.03950998
118DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03692333
119XRN2_22483619_ChIP-Seq_HELA_Human1.03521043
120SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03227059
121CTCF_21964334_ChIP-Seq_BJAB-B_Human1.02856967
122CTCF_21964334_Chip-Seq_Bcells_Human1.01867177
123RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01823093
124JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.01743962
125SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01429354
126REST_18959480_ChIP-ChIP_MESCs_Mouse1.01039215
127* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.00761736
128CTCF_20526341_ChIP-Seq_ESCs_Human1.00643381
129HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00560630
130* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00554537
131SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00399568

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ3.53155608
2MP0003122_maternal_imprinting3.41674624
3MP0005423_abnormal_somatic_nervous3.36728838
4MP0010030_abnormal_orbit_morphology2.98801513
5MP0000537_abnormal_urethra_morphology2.78842660
6MP0003123_paternal_imprinting2.73799609
7MP0002653_abnormal_ependyma_morphology2.70278538
8MP0005409_darkened_coat_color2.50825749
9MP0002234_abnormal_pharynx_morphology2.41099977
10MP0000566_synostosis2.34722549
11MP0002822_catalepsy2.28215585
12MP0004859_abnormal_synaptic_plasticity2.25013923
13MP0000751_myopathy2.17159670
14MP0003119_abnormal_digestive_system2.14697014
15MP0004858_abnormal_nervous_system2.12681992
16MP0003705_abnormal_hypodermis_morpholog2.10194968
17MP0003942_abnormal_urinary_system2.05714300
18MP0000534_abnormal_ureter_morphology1.92044589
19MP0003121_genomic_imprinting1.86435764
20MP0005623_abnormal_meninges_morphology1.85688700
21MP0000049_abnormal_middle_ear1.85325751
22MP0001188_hyperpigmentation1.84381622
23MP0003115_abnormal_respiratory_system1.83029622
24MP0003385_abnormal_body_wall1.79739495
25MP0002249_abnormal_larynx_morphology1.74507596
26MP0009053_abnormal_anal_canal1.74286210
27MP0001502_abnormal_circadian_rhythm1.67319961
28MP0000778_abnormal_nervous_system1.63457005
29MP0009379_abnormal_foot_pigmentation1.61057704
30MP0003329_amyloid_beta_deposits1.60916108
31MP0000428_abnormal_craniofacial_morphol1.55840802
32MP0004133_heterotaxia1.55442675
33MP0004233_abnormal_muscle_weight1.54557707
34MP0002932_abnormal_joint_morphology1.53130525
35MP0003879_abnormal_hair_cell1.51161370
36MP0003136_yellow_coat_color1.49035032
37MP0005187_abnormal_penis_morphology1.46130324
38MP0008961_abnormal_basal_metabolism1.44297460
39MP0003861_abnormal_nervous_system1.40912881
40MP0002282_abnormal_trachea_morphology1.39661906
41MP0003935_abnormal_craniofacial_develop1.38369260
42MP0000678_abnormal_parathyroid_gland1.38335477
43MP0003567_abnormal_fetal_cardiomyocyte1.37359890
44MP0009780_abnormal_chondrocyte_physiolo1.37233102
45MP0008789_abnormal_olfactory_epithelium1.37190076
46MP0003878_abnormal_ear_physiology1.35091137
47MP0005377_hearing/vestibular/ear_phenot1.35091137
48MP0001849_ear_inflammation1.34393694
49MP0004145_abnormal_muscle_electrophysio1.31985732
50MP0009278_abnormal_bone_marrow1.31728252
51MP0002909_abnormal_adrenal_gland1.30872222
52MP0004272_abnormal_basement_membrane1.30869668
53MP0005394_taste/olfaction_phenotype1.30518516
54MP0005499_abnormal_olfactory_system1.30518516
55MP0002734_abnormal_mechanical_nocicepti1.30485594
56MP0002751_abnormal_autonomic_nervous1.28626480
57MP0001346_abnormal_lacrimal_gland1.26663610
58MP0000955_abnormal_spinal_cord1.24151649
59MP0009384_cardiac_valve_regurgitation1.23074698
60MP0002184_abnormal_innervation1.23000440
61MP0002116_abnormal_craniofacial_bone1.21160031
62MP0003635_abnormal_synaptic_transmissio1.19762829
63MP0002064_seizures1.18688719
64MP0003880_abnormal_central_pattern1.18243381
65MP0003315_abnormal_perineum_morphology1.17817840
66MP0002572_abnormal_emotion/affect_behav1.16054026
67MP0001968_abnormal_touch/_nociception1.15103993
68MP0000733_abnormal_muscle_development1.14965818
69MP0002084_abnormal_developmental_patter1.14589360
70MP0002089_abnormal_postnatal_growth/wei1.14498838
71MP0004197_abnormal_fetal_growth/weight/1.13358501
72MP0002233_abnormal_nose_morphology1.12401202
73MP0003755_abnormal_palate_morphology1.12366295
74MP0000631_abnormal_neuroendocrine_gland1.11795762
75MP0005058_abnormal_lysosome_morphology1.11661916
76MP0005666_abnormal_adipose_tissue1.10483705
77MP0008569_lethality_at_weaning1.10395665
78MP0004084_abnormal_cardiac_muscle1.10023606
79MP0005171_absent_coat_pigmentation1.09170936
80MP0004185_abnormal_adipocyte_glucose1.07992255
81MP0002085_abnormal_embryonic_tissue1.07981003
82MP0004811_abnormal_neuron_physiology1.07626800
83MP0005375_adipose_tissue_phenotype1.07561128
84MP0001270_distended_abdomen1.07519426
85MP0005503_abnormal_tendon_morphology1.05941705
86MP0009250_abnormal_appendicular_skeleto1.05809517
87MP0002735_abnormal_chemical_nociception1.05703477
88MP0003634_abnormal_glial_cell1.05591617
89MP0003137_abnormal_impulse_conducting1.04869183
90MP0002152_abnormal_brain_morphology1.04213292
91MP0001293_anophthalmia1.03261248
92MP0002697_abnormal_eye_size1.03034345
93MP0008260_abnormal_autophagy1.01659853
94MP0001970_abnormal_pain_threshold0.99728236
95MP0002081_perinatal_lethality0.99146257
96MP0000026_abnormal_inner_ear0.98954376
97MP0005076_abnormal_cell_differentiation0.97768730
98MP0002938_white_spotting0.97405437
99MP0003937_abnormal_limbs/digits/tail_de0.97292237
100MP0003172_abnormal_lysosome_physiology0.96381406
101MP0006292_abnormal_olfactory_placode0.95590502
102MP0004270_analgesia0.95427423
103MP0005248_abnormal_Harderian_gland0.93109563
104MP0005670_abnormal_white_adipose0.92396706
105MP0004885_abnormal_endolymph0.91149517
106MP0002063_abnormal_learning/memory/cond0.90677572
107MP0003787_abnormal_imprinting0.89935909
108MP0002882_abnormal_neuron_morphology0.89117952
109MP0002114_abnormal_axial_skeleton0.88814895
110MP0004087_abnormal_muscle_fiber0.88253135
111MP0008438_abnormal_cutaneous_collagen0.87414316
112MP0001486_abnormal_startle_reflex0.87355168
113MP0002896_abnormal_bone_mineralization0.86585502
114MP0003938_abnormal_ear_development0.86467210
115MP0000759_abnormal_skeletal_muscle0.85718844
116MP0002733_abnormal_thermal_nociception0.85213283
117MP0000681_abnormal_thyroid_gland0.85164126
118MP0000747_muscle_weakness0.84204839
119MP0010368_abnormal_lymphatic_system0.83400516
120MP0002092_abnormal_eye_morphology0.81645345
121MP0005257_abnormal_intraocular_pressure0.81537671
122MP0009672_abnormal_birth_weight0.81404949
123MP0002111_abnormal_tail_morphology0.81261080
124MP0010630_abnormal_cardiac_muscle0.80511894
125MP0002066_abnormal_motor_capabilities/c0.80276853
126MP0002557_abnormal_social/conspecific_i0.79727133
127MP0002106_abnormal_muscle_physiology0.78669515
128MP0001348_abnormal_lacrimal_gland0.78667922
129MP0003890_abnormal_embryonic-extraembry0.78490672
130MP0000003_abnormal_adipose_tissue0.77604035
131MP0000750_abnormal_muscle_regeneration0.75725157
132MP0002837_dystrophic_cardiac_calcinosis0.75314449
133MP0001958_emphysema0.74138943
134MP0006138_congestive_heart_failure0.73818479
135MP0001697_abnormal_embryo_size0.73249951
136MP0001299_abnormal_eye_distance/0.71789517
137MP0005369_muscle_phenotype0.71676888
138MP0005508_abnormal_skeleton_morphology0.71590493
139MP0001986_abnormal_taste_sensitivity0.71100261
140MP0003453_abnormal_keratinocyte_physiol0.70792114
141MP0004130_abnormal_muscle_cell0.69397476
142MP0000462_abnormal_digestive_system0.69333810
143MP0001963_abnormal_hearing_physiology0.68960688

Predicted human phenotypes

RankGene SetZ-score
1Renal duplication (HP:0000075)4.24709737
2Hyperacusis (HP:0010780)4.10449974
3Obstructive sleep apnea (HP:0002870)3.91352557
4Ulnar bowing (HP:0003031)3.58684643
5Insomnia (HP:0100785)3.52133442
6Elfin facies (HP:0004428)3.35431280
7Shallow orbits (HP:0000586)3.17277545
8Renovascular hypertension (HP:0100817)3.15331538
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.12659211
10Short 4th metacarpal (HP:0010044)3.12659211
11Overriding aorta (HP:0002623)3.10277610
12Thin bony cortex (HP:0002753)3.09306473
13Broad distal phalanx of finger (HP:0009836)3.07128100
14Bladder diverticulum (HP:0000015)2.97123474
15Abnormality of the 4th metacarpal (HP:0010012)2.81347627
16Protrusio acetabuli (HP:0003179)2.77194492
17Thin ribs (HP:0000883)2.76089811
18Abnormality of the lower motor neuron (HP:0002366)2.73880817
19Myopathic facies (HP:0002058)2.71389790
20Broad face (HP:0000283)2.70992116
21Rib fusion (HP:0000902)2.68249559
22Pointed chin (HP:0000307)2.65392186
23Flat cornea (HP:0007720)2.60316297
24Lymphangioma (HP:0100764)2.55808499
25Bowel diverticulosis (HP:0005222)2.54105322
26Coronal craniosynostosis (HP:0004440)2.51072975
27Atelectasis (HP:0100750)2.49234745
28Hyperthyroidism (HP:0000836)2.40491350
29Long palpebral fissure (HP:0000637)2.39048108
30Annular pancreas (HP:0001734)2.37531331
31Partial duplication of thumb phalanx (HP:0009944)2.36497643
32Stridor (HP:0010307)2.36257505
33Akinesia (HP:0002304)2.35650706
34Testicular atrophy (HP:0000029)2.34575685
35Abnormality of the aortic arch (HP:0012303)2.33827017
36Cerebral aneurysm (HP:0004944)2.33047520
37Broad metatarsal (HP:0001783)2.32947263
38Neoplasm of the heart (HP:0100544)2.32214480
39Hypoventilation (HP:0002791)2.31574010
40Increased variability in muscle fiber diameter (HP:0003557)2.31477837
41Bronchomalacia (HP:0002780)2.26540658
42Enlarged penis (HP:0000040)2.26376076
43Cervical subluxation (HP:0003308)2.26251942
44Supranuclear gaze palsy (HP:0000605)2.23541125
45Disproportionate tall stature (HP:0001519)2.19974858
46Truncus arteriosus (HP:0001660)2.19915661
47Deviation of the hallux (HP:0010051)2.19624935
48Abnormality of the diencephalon (HP:0010662)2.17591993
49Mitral regurgitation (HP:0001653)2.17135303
50Hallux valgus (HP:0001822)2.16350537
51Choanal stenosis (HP:0000452)2.15178221
52Megalencephaly (HP:0001355)2.15091006
53Partial duplication of the phalanx of hand (HP:0009999)2.12111684
54Hypercortisolism (HP:0001578)2.09178626
55Biconcave vertebral bodies (HP:0004586)2.08984370
56Shoulder girdle muscle weakness (HP:0003547)2.06922727
57Ankle contracture (HP:0006466)2.05883904
58Myokymia (HP:0002411)2.04430006
59Metaphyseal cupping (HP:0003021)2.03820546
60Hepatoblastoma (HP:0002884)2.00836238
61Vaginal fistula (HP:0004320)1.99951855
62Ankle clonus (HP:0011448)1.98574043
63Turricephaly (HP:0000262)1.97869882
64Megalocornea (HP:0000485)1.97642153
65Increased nuchal translucency (HP:0010880)1.96776692
66Pelvic girdle muscle weakness (HP:0003749)1.96688520
67Intestinal fistula (HP:0100819)1.94083471
68Abnormality of skeletal muscle fiber size (HP:0012084)1.93266489
69Facial hemangioma (HP:0000329)1.92969433
70Sleep apnea (HP:0010535)1.92094696
71Termporal pattern (HP:0011008)1.91072188
72Insidious onset (HP:0003587)1.91072188
73Back pain (HP:0003418)1.89820524
74Ependymoma (HP:0002888)1.89644916
75Germ cell neoplasia (HP:0100728)1.89504752
76Adducted thumb (HP:0001181)1.89299678
77Flattened epiphyses (HP:0003071)1.88923277
78Mildly elevated creatine phosphokinase (HP:0008180)1.86071937
79Sacral dimple (HP:0000960)1.85740631
80Delayed epiphyseal ossification (HP:0002663)1.84782067
81Hypercalcemia (HP:0003072)1.83540749
82Bell-shaped thorax (HP:0001591)1.82392423
83Rectal prolapse (HP:0002035)1.82227681
84Arnold-Chiari malformation (HP:0002308)1.81446840
85Absent epiphyses (HP:0010577)1.81003441
86Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.81003441
87Sudden death (HP:0001699)1.80850501
88Difficulty climbing stairs (HP:0003551)1.79964588
89Buphthalmos (HP:0000557)1.79538484
90Difficulty running (HP:0009046)1.79370200
91Hand muscle atrophy (HP:0009130)1.78799937
92Generalized hypotonia (HP:0001290)1.77688712
93Fetal akinesia sequence (HP:0001989)1.77438174
94Bowing of the arm (HP:0006488)1.77337091
95Bowed forearm bones (HP:0003956)1.77337091
96Upper limb amyotrophy (HP:0009129)1.76163377
97Distal upper limb amyotrophy (HP:0007149)1.76163377
98Precocious puberty (HP:0000826)1.75678422
99Spina bifida occulta (HP:0003298)1.75598404
100Limb-girdle muscle atrophy (HP:0003797)1.74768197
101Neurofibrillary tangles (HP:0002185)1.74728144
102High anterior hairline (HP:0009890)1.74607423
103Long toe (HP:0010511)1.74190546
104Broad thumb (HP:0011304)1.74085649
105Patellar dislocation (HP:0002999)1.73203270
106Genu recurvatum (HP:0002816)1.72123628
107Abnormality of the musculature of the pelvis (HP:0001469)1.71775798
108Abnormality of the hip-girdle musculature (HP:0001445)1.71775798
109Congenital glaucoma (HP:0001087)1.71324836
110Bowel incontinence (HP:0002607)1.71130292
111Abnormality of the distal phalanx of the thumb (HP:0009617)1.69501845
112Type 1 muscle fiber predominance (HP:0003803)1.69115050
113Agitation (HP:0000713)1.68954042
114Rectal fistula (HP:0100590)1.68516142
115Rectovaginal fistula (HP:0000143)1.68516142
116Astrocytoma (HP:0009592)1.68145761
117Abnormality of the astrocytes (HP:0100707)1.68145761
118Limb-girdle muscle weakness (HP:0003325)1.68079794
119Colon cancer (HP:0003003)1.66977975
120Adenoma sebaceum (HP:0009720)1.66637166
121Angiofibromas (HP:0010615)1.66637166
122Spinal canal stenosis (HP:0003416)1.66625034
123Depression (HP:0000716)1.63816167
124Visual hallucinations (HP:0002367)1.63555825
125Peritonitis (HP:0002586)1.63355987
126Ventricular fibrillation (HP:0001663)1.63343530
127Hyperparathyroidism (HP:0000843)1.62239651
128Mitral valve prolapse (HP:0001634)1.61672223
129Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.61646499
130Joint stiffness (HP:0001387)1.61493693
131Abnormality of the phalanges of the hallux (HP:0010057)1.60909645
132Testicular neoplasm (HP:0010788)1.60399571
133Vitreoretinal degeneration (HP:0000655)1.60385628
134Macroorchidism (HP:0000053)1.60038599
135Fibroma (HP:0010614)1.59394668
136Aplasia involving bones of the upper limbs (HP:0009823)1.59227669
137Aplasia of the phalanges of the hand (HP:0009802)1.59227669
138Aplasia involving bones of the extremities (HP:0009825)1.59227669
139Hemorrhage of the eye (HP:0011885)1.59142445
140Cerebral inclusion bodies (HP:0100314)1.58480936
141Nuclear cataract (HP:0100018)1.58402181
142Broad finger (HP:0001500)1.58019302
143Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.56970188
144Fibrous tissue neoplasm (HP:0012316)1.56922354
145Deep palmar crease (HP:0006191)1.56516501
146Abnormality of the Achilles tendon (HP:0005109)1.56374391
147Intestinal polyp (HP:0005266)1.55616517
148Abnormality of the calcaneus (HP:0008364)1.55125647
149Achilles tendon contracture (HP:0001771)1.54843028
150Hypercalciuria (HP:0002150)1.54787279
151Broad phalanges of the hand (HP:0009768)1.54753026
152Amblyopia (HP:0000646)1.54016682
153Obsessive-compulsive behavior (HP:0000722)1.53901956
154Trigonocephaly (HP:0000243)1.53820000
155Ankyloglossia (HP:0010296)1.53770456
156Large eyes (HP:0001090)1.53259536
157Wide anterior fontanel (HP:0000260)1.51998202
158Broad toe (HP:0001837)1.51858905

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.25993250
2PKN23.07640070
3SMG12.80194538
4EEF2K2.77611998
5EPHB22.57976596
6PRKD32.56174345
7MAP3K102.54774556
8ICK2.32732568
9MAPK152.24307082
10RIPK12.18506757
11PDGFRA2.08443291
12PRPF4B2.00755052
13LATS21.99091079
14TYRO31.98726268
15KSR11.95555426
16MARK11.92908726
17MAP3K91.90906830
18DDR21.59672446
19KSR21.59502800
20DYRK31.56742024
21UHMK11.56224371
22PHKG21.48504706
23PHKG11.48504706
24LMTK21.45419707
25NEK11.40896981
26PTK61.38674692
27ARAF1.33290670
28PAK61.32946500
29ILK1.31009686
30NTRK21.30588973
31MINK11.27959245
32CAMKK11.27497444
33NTRK31.26434318
34TTN1.23399040
35FGFR41.18435063
36PASK1.16244550
37BRAF1.16151036
38PAK41.14716156
39CDK191.10117797
40ERBB21.06429688
41DAPK21.03810894
42SIK20.99751085
43ERN10.97747815
44TNK20.97593827
45TAOK10.96296843
46SIK10.94974228
47RET0.94370288
48TGFBR10.93132616
49MTOR0.92866263
50DYRK1B0.92579937
51LIMK10.92136059
52MAP2K20.89739174
53RPS6KC10.89620871
54RPS6KL10.89620871
55MAP3K40.89514163
56MAP3K70.89001802
57PDPK10.87674842
58MAP2K30.87401372
59PTK20.86584524
60FER0.85469581
61RPS6KA20.85084657
62DYRK20.83748515
63DMPK0.81340094
64ALK0.80456435
65NTRK10.80362017
66SCYL20.79958258
67PRKD20.79925275
68TESK10.79582602
69MAPK130.78926501
70PAK20.77838442
71MAP3K110.77179054
72LATS10.76580222
73CAMK1G0.76439154
74STK110.74912317
75CDC42BPA0.74396557
76MAPKAPK30.72627295
77RPS6KA60.71216112
78EPHA20.71086213
79CDK140.70977165
80LRRK20.70823731
81EPHB10.70346033
82PAK30.70154229
83CDK11A0.70067312
84HIPK20.69000788
85FGFR10.68755986
86CDK150.68091596
87DAPK30.68090515
88CDK180.68002156
89SGK2230.67301690
90SGK4940.67301690
91NEK20.66416590
92MAPK120.65598191
93CAMK10.65408076
94EPHA40.63584124
95MAP3K10.63490088
96CDK120.62680807
97CAMK1D0.61509982
98STK380.60938815
99CAMK40.60103220
100RPS6KB20.59885987
101MAP3K130.58592999
102TAOK20.57424556
103CDK50.55959731
104DAPK10.55644371
105MARK20.53643368
106WNK10.53360675
107BMX0.52762815
108AKT20.52354284
109AURKA0.51666144
110PRKD10.51225644
111BCKDK0.51158683
112PRKCH0.49895999
113BRSK10.49161144
114NME20.48479257
115ROCK10.47523226
116MAP2K40.47406093
117MAPK80.46931782
118IRAK20.46844814
119IRAK30.46222428
120RPS6KA10.45941411
121MAPK100.45828045
122FGFR20.45469180
123ERBB30.45342900
124MAPK90.43530322
125SGK30.43292314
126PRKCZ0.43129945
127CDK40.42488794
128CDK70.42191223
129PTK2B0.40265077
130CSNK1G20.39975624
131CSNK1G30.39388968
132WNK30.38641191
133TESK20.38026900

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.61731880
2Hedgehog signaling pathway_Homo sapiens_hsa043402.38442133
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.11877238
4Notch signaling pathway_Homo sapiens_hsa043302.05505165
5Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.03043749
6Hippo signaling pathway_Homo sapiens_hsa043901.93246606
7Melanogenesis_Homo sapiens_hsa049161.75041870
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.63658785
9Axon guidance_Homo sapiens_hsa043601.62366160
10Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57780793
11Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.55053526
12Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.52997117
13Gap junction_Homo sapiens_hsa045401.52617572
14Endometrial cancer_Homo sapiens_hsa052131.44447994
15Bladder cancer_Homo sapiens_hsa052191.42070868
16Wnt signaling pathway_Homo sapiens_hsa043101.41241646
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40750393
18Circadian entrainment_Homo sapiens_hsa047131.37676370
19Insulin secretion_Homo sapiens_hsa049111.36518422
20Glioma_Homo sapiens_hsa052141.35841028
21Cocaine addiction_Homo sapiens_hsa050301.35282776
22Dopaminergic synapse_Homo sapiens_hsa047281.34615411
23Dilated cardiomyopathy_Homo sapiens_hsa054141.34493166
24Estrogen signaling pathway_Homo sapiens_hsa049151.34043729
25Colorectal cancer_Homo sapiens_hsa052101.33799945
26Thyroid hormone signaling pathway_Homo sapiens_hsa049191.31559203
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.31057903
28Synaptic vesicle cycle_Homo sapiens_hsa047211.28657705
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.28416967
30Fructose and mannose metabolism_Homo sapiens_hsa000511.25542408
31Chronic myeloid leukemia_Homo sapiens_hsa052201.25213849
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24639765
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23653405
34Olfactory transduction_Homo sapiens_hsa047401.23424712
35Neurotrophin signaling pathway_Homo sapiens_hsa047221.23210089
36Oocyte meiosis_Homo sapiens_hsa041141.23111352
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20195200
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.19807384
39Proteoglycans in cancer_Homo sapiens_hsa052051.16430189
40Other glycan degradation_Homo sapiens_hsa005111.16220800
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15641834
42mTOR signaling pathway_Homo sapiens_hsa041501.12537908
43GnRH signaling pathway_Homo sapiens_hsa049121.12324838
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11983458
45Spliceosome_Homo sapiens_hsa030401.11645268
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11522969
47Cholinergic synapse_Homo sapiens_hsa047251.11092191
48Amphetamine addiction_Homo sapiens_hsa050311.09810512
49Thyroid cancer_Homo sapiens_hsa052161.09341454
50Non-small cell lung cancer_Homo sapiens_hsa052231.08113452
51VEGF signaling pathway_Homo sapiens_hsa043701.07468979
52Tight junction_Homo sapiens_hsa045301.06788811
53Insulin signaling pathway_Homo sapiens_hsa049101.06136247
54mRNA surveillance pathway_Homo sapiens_hsa030151.05409979
55Inositol phosphate metabolism_Homo sapiens_hsa005621.03932441
56Long-term potentiation_Homo sapiens_hsa047201.03823339
57GABAergic synapse_Homo sapiens_hsa047271.03295035
58Choline metabolism in cancer_Homo sapiens_hsa052311.02530756
59Oxytocin signaling pathway_Homo sapiens_hsa049211.02313981
60Acute myeloid leukemia_Homo sapiens_hsa052211.01950328
61Focal adhesion_Homo sapiens_hsa045101.01455081
62Cardiac muscle contraction_Homo sapiens_hsa042601.00884342
63Glucagon signaling pathway_Homo sapiens_hsa049220.98316805
64Gastric acid secretion_Homo sapiens_hsa049710.97588103
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97021059
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96550557
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96017926
68Renal cell carcinoma_Homo sapiens_hsa052110.96011349
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94741627
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94112616
71Glutamatergic synapse_Homo sapiens_hsa047240.91642689
72Dorso-ventral axis formation_Homo sapiens_hsa043200.90318893
73Protein digestion and absorption_Homo sapiens_hsa049740.89292033
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89197703
75Type II diabetes mellitus_Homo sapiens_hsa049300.88006762
76Nicotine addiction_Homo sapiens_hsa050330.87630944
77MicroRNAs in cancer_Homo sapiens_hsa052060.87447867
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86462727
79Biosynthesis of amino acids_Homo sapiens_hsa012300.85215277
80Alcoholism_Homo sapiens_hsa050340.84707325
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84359886
82Adherens junction_Homo sapiens_hsa045200.83998463
83TGF-beta signaling pathway_Homo sapiens_hsa043500.83734830
84MAPK signaling pathway_Homo sapiens_hsa040100.82785859
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.82678876
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80951307
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80254280
88Pathways in cancer_Homo sapiens_hsa052000.79965965
89Phenylalanine metabolism_Homo sapiens_hsa003600.79777022
90AMPK signaling pathway_Homo sapiens_hsa041520.79596674
91ErbB signaling pathway_Homo sapiens_hsa040120.79565871
92Lysine degradation_Homo sapiens_hsa003100.78168699
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77855573
94Rap1 signaling pathway_Homo sapiens_hsa040150.75537530
95ECM-receptor interaction_Homo sapiens_hsa045120.75400558
96N-Glycan biosynthesis_Homo sapiens_hsa005100.73741729
97Prion diseases_Homo sapiens_hsa050200.73723429
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73412841
99Insulin resistance_Homo sapiens_hsa049310.72771626
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72594566
101cAMP signaling pathway_Homo sapiens_hsa040240.71733963
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71508974
103Renin secretion_Homo sapiens_hsa049240.70625753
104Pancreatic cancer_Homo sapiens_hsa052120.70438025
105Morphine addiction_Homo sapiens_hsa050320.68610545
106Bile secretion_Homo sapiens_hsa049760.67462975
107Vibrio cholerae infection_Homo sapiens_hsa051100.65741437
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64331768
109Thyroid hormone synthesis_Homo sapiens_hsa049180.64199239
110Nitrogen metabolism_Homo sapiens_hsa009100.63190966
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.62992408
112Small cell lung cancer_Homo sapiens_hsa052220.61288274
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60756621
114Sulfur relay system_Homo sapiens_hsa041220.60180331
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.60024472
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59098729
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.57936496
118Salivary secretion_Homo sapiens_hsa049700.57314049
119Calcium signaling pathway_Homo sapiens_hsa040200.57276701
120Long-term depression_Homo sapiens_hsa047300.56836881
121HTLV-I infection_Homo sapiens_hsa051660.56516005
122Endocytosis_Homo sapiens_hsa041440.55049178
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54533038
124Arginine and proline metabolism_Homo sapiens_hsa003300.54309891
125Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53833682
126Melanoma_Homo sapiens_hsa052180.53664679
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53416590

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