PTN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a secreted heparin-binding growth factor. The protein has significant roles in cell growth and survival, cell migration, angiogenesis and tumorigenesis. Alternative splicing and the use of alternative promoters results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.19118286
2central nervous system myelination (GO:0022010)8.19118286
3fatty acid elongation (GO:0030497)5.43336839
4myelination (GO:0042552)5.37001736
5axon ensheathment (GO:0008366)5.34015891
6ensheathment of neurons (GO:0007272)5.34015891
7pyrimidine nucleobase catabolic process (GO:0006208)5.18343363
8presynaptic membrane assembly (GO:0097105)4.64212369
9neuronal stem cell maintenance (GO:0097150)4.50919126
10presynaptic membrane organization (GO:0097090)4.49556509
11long-chain fatty acid biosynthetic process (GO:0042759)4.26244677
12oligodendrocyte differentiation (GO:0048709)4.13848396
13negative regulation of neurotransmitter transport (GO:0051589)4.11513261
14negative regulation of neurotransmitter secretion (GO:0046929)4.07409077
15Notch signaling involved in heart development (GO:0061314)4.05254583
16apical protein localization (GO:0045176)3.96301050
17neuron cell-cell adhesion (GO:0007158)3.93959021
18positive regulation of vascular permeability (GO:0043117)3.91340045
19nucleobase catabolic process (GO:0046113)3.91030232
20asymmetric protein localization (GO:0008105)3.79086882
21photoreceptor cell differentiation (GO:0046530)3.76849941
22eye photoreceptor cell differentiation (GO:0001754)3.76849941
23startle response (GO:0001964)3.73019517
24myelin maintenance (GO:0043217)3.69527716
25spinal cord development (GO:0021510)3.69159505
26negative regulation of protein localization to cell surface (GO:2000009)3.66013908
27astrocyte differentiation (GO:0048708)3.64584529
28cerebral cortex radially oriented cell migration (GO:0021799)3.61354353
29L-amino acid import (GO:0043092)3.56668588
30astrocyte development (GO:0014002)3.53533383
31lateral sprouting from an epithelium (GO:0060601)3.51586855
32cholesterol biosynthetic process (GO:0006695)3.49853966
33limb bud formation (GO:0060174)3.47232178
34peripheral nervous system axon ensheathment (GO:0032292)3.43558655
35myelination in peripheral nervous system (GO:0022011)3.43558655
36radial glial cell differentiation (GO:0060019)3.40839686
37cerebellar granule cell differentiation (GO:0021707)3.40158244
38heart valve formation (GO:0003188)3.38853688
39negative regulation of oligodendrocyte differentiation (GO:0048715)3.38113808
40retinal ganglion cell axon guidance (GO:0031290)3.37216253
41nonmotile primary cilium assembly (GO:0035058)3.33399526
42calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.30780256
43cell migration in hindbrain (GO:0021535)3.30688856
44regulation of axon extension involved in axon guidance (GO:0048841)3.26684623
45tongue development (GO:0043586)3.25938215
46cellular response to cholesterol (GO:0071397)3.23326516
47synapse assembly (GO:0007416)3.22835060
48cerebral cortex cell migration (GO:0021795)3.16637506
49establishment of planar polarity (GO:0001736)3.15955544
50establishment of tissue polarity (GO:0007164)3.15955544
51suckling behavior (GO:0001967)3.14598950
52synaptic transmission, glutamatergic (GO:0035249)3.12701592
53negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.12070677
54regulation of axon guidance (GO:1902667)3.11600029
55vocalization behavior (GO:0071625)3.08340303
56transmission of nerve impulse (GO:0019226)3.04907059
57positive regulation of oligodendrocyte differentiation (GO:0048714)3.04339642
58sterol biosynthetic process (GO:0016126)3.02271667
59negative regulation of JUN kinase activity (GO:0043508)3.00239196
60establishment of mitochondrion localization (GO:0051654)2.99203694
61lens fiber cell development (GO:0070307)2.98300338
62appendage development (GO:0048736)2.96780815
63limb development (GO:0060173)2.96780815
64regulation of collateral sprouting (GO:0048670)2.96363197
65adhesion of symbiont to host cell (GO:0044650)2.96214621
66virion attachment to host cell (GO:0019062)2.96214621
67neuron recognition (GO:0008038)2.95834742
68negative regulation of astrocyte differentiation (GO:0048712)2.95484044
69amino acid import (GO:0043090)2.94877817
70substantia nigra development (GO:0021762)2.93892861
71axonal fasciculation (GO:0007413)2.92590167
72glycerophospholipid catabolic process (GO:0046475)2.88976574
73positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.87987505
74negative regulation of axonogenesis (GO:0050771)2.87837542
75regulation of respiratory system process (GO:0044065)2.87148555
76axon extension (GO:0048675)2.85236965
77epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.84837605
78coronary vasculature morphogenesis (GO:0060977)2.83767972
79neurotransmitter-gated ion channel clustering (GO:0072578)2.81695443
80endocardial cushion morphogenesis (GO:0003203)2.79745232
81import into cell (GO:0098657)2.79059065
82dendritic spine morphogenesis (GO:0060997)2.78020093
83regulation of synapse structural plasticity (GO:0051823)2.77237155
84neuron migration (GO:0001764)2.77112055
85response to methylmercury (GO:0051597)2.76406984
86membrane assembly (GO:0071709)2.75962304
87isoprenoid biosynthetic process (GO:0008299)2.75515927
88peripheral nervous system neuron development (GO:0048935)2.74040042
89central nervous system neuron axonogenesis (GO:0021955)2.72847161
90positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.72452657
91regulation of penile erection (GO:0060405)2.72144120
92neuronal action potential propagation (GO:0019227)2.70388622
93negative regulation of axon extension (GO:0030517)2.69833624
94peptidyl-tyrosine autophosphorylation (GO:0038083)2.68551122
95retinal rod cell development (GO:0046548)2.68006077
96negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.65354648
97cellular potassium ion homeostasis (GO:0030007)2.65152039
98pattern specification involved in kidney development (GO:0061004)2.64830979
99cell surface receptor signaling pathway involved in heart development (GO:0061311)2.63461222
100positive regulation of synapse assembly (GO:0051965)2.62781933
101long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.62769561
102bone trabecula formation (GO:0060346)2.62241578
103central nervous system neuron development (GO:0021954)2.62204774
104synapse organization (GO:0050808)2.60649628
105neuron fate determination (GO:0048664)2.60381139
106glial cell differentiation (GO:0010001)2.60366562
107response to lipoprotein particle (GO:0055094)2.59890174
108postsynaptic membrane organization (GO:0001941)2.59259385
109dendrite morphogenesis (GO:0048813)2.59214467
110L-serine transport (GO:0015825)2.58729816
111positive regulation of neuroblast proliferation (GO:0002052)2.58510352
112axon regeneration (GO:0031103)2.57517186
113L-serine metabolic process (GO:0006563)2.57385259
114organ growth (GO:0035265)2.57088625
115creatine metabolic process (GO:0006600)2.56680134
116neuromuscular junction development (GO:0007528)2.56572325
117embryonic retina morphogenesis in camera-type eye (GO:0060059)2.56493860
118ventricular trabecula myocardium morphogenesis (GO:0003222)2.56263965
119membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.55914042
120auditory behavior (GO:0031223)2.55464569
121dendrite development (GO:0016358)2.54434802
122cerebral cortex development (GO:0021987)2.54026816
123adult walking behavior (GO:0007628)2.53987883
124cellular response to sterol (GO:0036315)2.53590292
125lens morphogenesis in camera-type eye (GO:0002089)2.52954710
126response to redox state (GO:0051775)2.52951522
127negative regulation of glial cell differentiation (GO:0045686)2.52084601
128dermatan sulfate biosynthetic process (GO:0030208)2.51185954
129neurotransmitter uptake (GO:0001504)2.51157405
130axon development (GO:0061564)2.50223077
131regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.49955967
132C4-dicarboxylate transport (GO:0015740)2.48823163
133enteric nervous system development (GO:0048484)2.48433105
134axonogenesis (GO:0007409)2.48232410
135negative regulation of synaptic transmission, GABAergic (GO:0032229)2.47591442
136positive regulation of action potential (GO:0045760)2.46887082
137gamma-aminobutyric acid transport (GO:0015812)2.45239639
138regulation of somitogenesis (GO:0014807)2.43661183
139long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.42016432
140positive regulation of glial cell differentiation (GO:0045687)2.41190187
141protein palmitoylation (GO:0018345)2.41046465
142prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.40270680
143gamma-aminobutyric acid signaling pathway (GO:0007214)2.39102684
144regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.35868527
145peripheral nervous system development (GO:0007422)2.34905648
146neuronal ion channel clustering (GO:0045161)2.33889721
147neuron remodeling (GO:0016322)2.33411282
148mechanosensory behavior (GO:0007638)2.32856149
149regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.32207407
150protein localization to synapse (GO:0035418)2.31944197
151regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.31129271
152regulation of astrocyte differentiation (GO:0048710)2.31091415
153dermatan sulfate metabolic process (GO:0030205)2.28378451
154nerve growth factor signaling pathway (GO:0038180)2.27503927
155regulation of dendritic spine development (GO:0060998)2.25140369
156positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.25097713
157ionotropic glutamate receptor signaling pathway (GO:0035235)2.24850583
158regulation of dendritic spine morphogenesis (GO:0061001)2.24048481
159camera-type eye morphogenesis (GO:0048593)2.23112818
160layer formation in cerebral cortex (GO:0021819)2.23079794
161glutamate receptor signaling pathway (GO:0007215)2.22511814
162negative regulation of catenin import into nucleus (GO:0035414)2.20351772
163cellular response to epinephrine stimulus (GO:0071872)2.17952762
164central nervous system projection neuron axonogenesis (GO:0021952)2.17055590
165response to auditory stimulus (GO:0010996)2.16224722

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.23785192
2* GBX2_23144817_ChIP-Seq_PC3_Human3.31154659
3EZH2_22144423_ChIP-Seq_EOC_Human3.06437151
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94750507
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86531529
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.80687189
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.70780691
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64418703
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64418703
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.62987583
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62318152
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53957836
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.50891410
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46047576
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.36215400
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27096340
17* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.12683659
18AR_21572438_ChIP-Seq_LNCaP_Human2.12374920
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.12347838
20PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.11022820
21RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.04844930
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04500078
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.01267847
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97568089
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.95082322
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.93096880
27* TAF15_26573619_Chip-Seq_HEK293_Human1.92707950
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91869729
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84436316
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83871924
31* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.79266289
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.76415099
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73265055
34KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.71446998
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70189177
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69990716
37* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66824257
38IGF1R_20145208_ChIP-Seq_DFB_Human1.65267535
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61217031
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.60501375
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.59052933
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.57208758
43DROSHA_22980978_ChIP-Seq_HELA_Human1.57201074
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50704671
45FUS_26573619_Chip-Seq_HEK293_Human1.48344287
46* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44382800
47* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.43304259
48* P300_19829295_ChIP-Seq_ESCs_Human1.42139071
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41762707
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41735400
51ER_23166858_ChIP-Seq_MCF-7_Human1.39072694
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36864274
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34721704
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33213305
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32108524
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32108524
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30304333
58TBX3_20139965_ChIP-Seq_MESCs_Mouse1.29183192
59TBX3_20139965_ChIP-Seq_ESCs_Mouse1.27116994
60TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26998164
61* SMAD4_21799915_ChIP-Seq_A2780_Human1.26663417
62CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26104547
63RING1B_27294783_Chip-Seq_NPCs_Mouse1.24435917
64* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23564352
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.23558085
66CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.22462541
67SOX9_26525672_Chip-Seq_HEART_Mouse1.22383301
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22332006
69TP53_18474530_ChIP-ChIP_U2OS_Human1.22226688
70EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21847840
71* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21429833
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.21113313
73* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.21017766
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20700892
75* EP300_21415370_ChIP-Seq_HL-1_Mouse1.19939733
76VDR_22108803_ChIP-Seq_LS180_Human1.19723348
77REST_21632747_ChIP-Seq_MESCs_Mouse1.18929084
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16074768
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13527286
80RARB_27405468_Chip-Seq_BRAIN_Mouse1.12997960
81SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.12287079
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.12270645
83RNF2_27304074_Chip-Seq_NSC_Mouse1.12165041
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11618804
85AHR_22903824_ChIP-Seq_MCF-7_Human1.11495596
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10660015
87SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09237660
88POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08824363
89ISL1_27105846_Chip-Seq_CPCs_Mouse1.08406301
90SALL1_21062744_ChIP-ChIP_HESCs_Human1.08152531
91* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07994601
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07203583
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06955886
94* STAT3_23295773_ChIP-Seq_U87_Human1.06873397
95REST_18959480_ChIP-ChIP_MESCs_Mouse1.06157912
96* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02574026
97TP53_16413492_ChIP-PET_HCT116_Human1.02484683
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.02351909
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01782110
100TP53_20018659_ChIP-ChIP_R1E_Mouse1.01278039
101* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00921165
102* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00297387
103NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99697934
104RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99321073
105P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97832759
106AR_25329375_ChIP-Seq_VCAP_Human0.97234304
107SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96792086
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96036824
109TCF4_23295773_ChIP-Seq_U87_Human0.95261107
110* RUNX2_22187159_ChIP-Seq_PCA_Human0.94503221
111HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94483172
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94426568
113PRDM14_20953172_ChIP-Seq_ESCs_Human0.94163406
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93850287
115* NANOG_18555785_Chip-Seq_ESCs_Mouse0.92390905
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91824926
117POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91824926
118RXR_22108803_ChIP-Seq_LS180_Human0.91133629
119* EWS_26573619_Chip-Seq_HEK293_Human0.90939772
120* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90103021
121SMAD_19615063_ChIP-ChIP_OVARY_Human0.89676007

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.67930688
2MP0000920_abnormal_myelination3.49250256
3MP0004270_analgesia2.86161540
4MP0004859_abnormal_synaptic_plasticity2.63542262
5MP0005171_absent_coat_pigmentation2.60395690
6MP0003136_yellow_coat_color2.58834858
7MP0008438_abnormal_cutaneous_collagen2.54488208
8MP0000778_abnormal_nervous_system2.40597236
9MP0004885_abnormal_endolymph2.33160873
10MP0002638_abnormal_pupillary_reflex2.29903188
11MP0001486_abnormal_startle_reflex2.29002328
12MP0003690_abnormal_glial_cell2.26322098
13MP0006292_abnormal_olfactory_placode2.13620858
14MP0003329_amyloid_beta_deposits2.08808704
15MP0003950_abnormal_plasma_membrane2.04149329
16MP0005623_abnormal_meninges_morphology2.00227008
17* MP0003635_abnormal_synaptic_transmissio1.99242105
18MP0002272_abnormal_nervous_system1.98744946
19MP0001485_abnormal_pinna_reflex1.97533005
20MP0002064_seizures1.95754889
21MP0004742_abnormal_vestibular_system1.95287541
22MP0005503_abnormal_tendon_morphology1.92588232
23MP0003634_abnormal_glial_cell1.89632553
24MP0002653_abnormal_ependyma_morphology1.88494194
25MP0001984_abnormal_olfaction1.86886327
26MP0009745_abnormal_behavioral_response1.78712506
27MP0001905_abnormal_dopamine_level1.77454063
28MP0003878_abnormal_ear_physiology1.77364779
29MP0005377_hearing/vestibular/ear_phenot1.77364779
30MP0005423_abnormal_somatic_nervous1.77355079
31MP0009250_abnormal_appendicular_skeleto1.75278951
32MP0001529_abnormal_vocalization1.68322069
33MP0004134_abnormal_chest_morphology1.66316076
34MP0002734_abnormal_mechanical_nocicepti1.60953507
35MP0003121_genomic_imprinting1.57958499
36MP0009046_muscle_twitch1.56947595
37MP0002063_abnormal_learning/memory/cond1.56907587
38MP0001299_abnormal_eye_distance/1.55074207
39MP0009053_abnormal_anal_canal1.53805832
40MP0005499_abnormal_olfactory_system1.53030416
41MP0005394_taste/olfaction_phenotype1.53030416
42MP0002572_abnormal_emotion/affect_behav1.48502542
43MP0000566_synostosis1.45663848
44MP0003938_abnormal_ear_development1.45145872
45MP0005187_abnormal_penis_morphology1.43981642
46MP0000516_abnormal_urinary_system1.43043812
47MP0005367_renal/urinary_system_phenotyp1.43043812
48MP0003937_abnormal_limbs/digits/tail_de1.42946164
49MP0001293_anophthalmia1.42261618
50MP0001968_abnormal_touch/_nociception1.41427070
51MP0002909_abnormal_adrenal_gland1.41324209
52MP0008789_abnormal_olfactory_epithelium1.40167976
53MP0002249_abnormal_larynx_morphology1.37391884
54MP0004142_abnormal_muscle_tone1.36242978
55MP0000462_abnormal_digestive_system1.35721190
56MP0009384_cardiac_valve_regurgitation1.35701565
57MP0000049_abnormal_middle_ear1.35304041
58MP0005409_darkened_coat_color1.33917762
59MP0002736_abnormal_nociception_after1.33855476
60MP0003385_abnormal_body_wall1.33470304
61MP0000955_abnormal_spinal_cord1.33186802
62MP0000762_abnormal_tongue_morphology1.33102318
63MP0004858_abnormal_nervous_system1.32765781
64MP0001346_abnormal_lacrimal_gland1.31337708
65MP0000026_abnormal_inner_ear1.30761884
66MP0002882_abnormal_neuron_morphology1.30236079
67MP0003632_abnormal_nervous_system1.29844892
68* MP0001963_abnormal_hearing_physiology1.27803869
69MP0001440_abnormal_grooming_behavior1.25794922
70MP0010678_abnormal_skin_adnexa1.24273600
71MP0002067_abnormal_sensory_capabilities1.24066791
72MP0002697_abnormal_eye_size1.23640047
73MP0000569_abnormal_digit_pigmentation1.22615533
74MP0002822_catalepsy1.21677096
75MP0003283_abnormal_digestive_organ1.20950237
76MP0004272_abnormal_basement_membrane1.19217561
77MP0000534_abnormal_ureter_morphology1.18436483
78MP0009780_abnormal_chondrocyte_physiolo1.17420674
79MP0000383_abnormal_hair_follicle1.16889446
80MP0004811_abnormal_neuron_physiology1.16494544
81MP0003755_abnormal_palate_morphology1.16231857
82MP0001502_abnormal_circadian_rhythm1.15638393
83MP0008569_lethality_at_weaning1.15154816
84MP0005257_abnormal_intraocular_pressure1.14772952
85MP0002234_abnormal_pharynx_morphology1.09883770
86MP0002295_abnormal_pulmonary_circulatio1.09015616
87MP0002184_abnormal_innervation1.08864382
88MP0005508_abnormal_skeleton_morphology1.08370108
89MP0002092_abnormal_eye_morphology1.07013048
90MP0001879_abnormal_lymphatic_vessel1.05747238
91MP0002752_abnormal_somatic_nervous1.05638821
92MP0003631_nervous_system_phenotype1.05492353
93MP0010368_abnormal_lymphatic_system1.05141744
94MP0002229_neurodegeneration1.04452565
95MP0001970_abnormal_pain_threshold1.04028482
96MP0002066_abnormal_motor_capabilities/c1.04022389
97MP0001286_abnormal_eye_development1.03132850
98MP0002938_white_spotting1.03035807
99MP0004133_heterotaxia1.02863460
100MP0006276_abnormal_autonomic_nervous1.01972862
101MP0003942_abnormal_urinary_system1.01653828
102MP0002152_abnormal_brain_morphology1.00088213
103MP0005391_vision/eye_phenotype1.00034733
104MP0002233_abnormal_nose_morphology0.99741045
105MP0004924_abnormal_behavior0.98465488
106MP0005386_behavior/neurological_phenoty0.98465488
107MP0005253_abnormal_eye_physiology0.98396577
108MP0005551_abnormal_eye_electrophysiolog0.98293857
109MP0001177_atelectasis0.97963031
110MP0002108_abnormal_muscle_morphology0.97642103
111MP0002733_abnormal_thermal_nociception0.96741367
112MP0003633_abnormal_nervous_system0.96410526
113MP0002557_abnormal_social/conspecific_i0.94423351
114MP0003935_abnormal_craniofacial_develop0.93808354
115MP0000631_abnormal_neuroendocrine_gland0.93776387
116MP0001340_abnormal_eyelid_morphology0.93653790
117MP0000428_abnormal_craniofacial_morphol0.93526076
118MP0003011_delayed_dark_adaptation0.93118237
119MP0001958_emphysema0.91419561
120MP0002102_abnormal_ear_morphology0.89946649
121MP0003119_abnormal_digestive_system0.89613409
122MP0000579_abnormal_nail_morphology0.88875056
123MP0005275_abnormal_skin_tensile0.87122026
124MP0002877_abnormal_melanocyte_morpholog0.86562715
125MP0003122_maternal_imprinting0.86038179
126MP0000647_abnormal_sebaceous_gland0.85846052
127MP0002116_abnormal_craniofacial_bone0.85749216
128MP0005195_abnormal_posterior_eye0.84398472
129MP0005410_abnormal_fertilization0.81275018
130MP0006072_abnormal_retinal_apoptosis0.81176876
131MP0002735_abnormal_chemical_nociception0.81132627
132MP0000467_abnormal_esophagus_morphology0.80436460
133MP0005248_abnormal_Harderian_gland0.80302820
134MP0000604_amyloidosis0.80279690
135MP0003861_abnormal_nervous_system0.79369725
136MP0000537_abnormal_urethra_morphology0.78100862

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.41099798
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.00282568
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.00282568
4Cerebral inclusion bodies (HP:0100314)4.09550432
5Aplasia involving bones of the extremities (HP:0009825)3.96206037
6Aplasia involving bones of the upper limbs (HP:0009823)3.96206037
7Aplasia of the phalanges of the hand (HP:0009802)3.96206037
8Abnormality of the corticospinal tract (HP:0002492)3.71394272
9Sensory axonal neuropathy (HP:0003390)3.62267074
10Parakeratosis (HP:0001036)3.51906178
11Megalencephaly (HP:0001355)3.29105821
12Abnormality of the ischium (HP:0003174)3.25967785
13Hemiplegia (HP:0002301)3.22471540
14Alacrima (HP:0000522)3.20588365
15Coronal craniosynostosis (HP:0004440)3.17568180
16Peripheral hypomyelination (HP:0007182)3.08431138
17Wide anterior fontanel (HP:0000260)3.04612549
18Supranuclear gaze palsy (HP:0000605)2.91162988
19Humeroradial synostosis (HP:0003041)2.88487989
20Synostosis involving the elbow (HP:0003938)2.88487989
21Termporal pattern (HP:0011008)2.80281781
22Insidious onset (HP:0003587)2.80281781
23Vertebral arch anomaly (HP:0008438)2.78417484
24Premature rupture of membranes (HP:0001788)2.76348910
25True hermaphroditism (HP:0010459)2.73992389
26Abnormality of the diencephalon (HP:0010662)2.66738866
27Thickened helices (HP:0000391)2.66472552
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.66190107
29Short 4th metacarpal (HP:0010044)2.66190107
30Spastic gait (HP:0002064)2.64960326
31Myokymia (HP:0002411)2.61908213
32Infantile muscular hypotonia (HP:0008947)2.61875748
33Polyphagia (HP:0002591)2.59708583
34Epileptic encephalopathy (HP:0200134)2.57986382
35Vitreoretinal degeneration (HP:0000655)2.57854554
36Bell-shaped thorax (HP:0001591)2.57700855
37Abnormality of the middle phalanges of the toes (HP:0010183)2.57279456
38Calcaneovalgus deformity (HP:0001848)2.56676098
39Hypoplastic pelvis (HP:0008839)2.53564524
40Abnormal auditory evoked potentials (HP:0006958)2.52116993
41Retinal dysplasia (HP:0007973)2.49462900
42Cutaneous syndactyly (HP:0012725)2.46009809
43Hepatoblastoma (HP:0002884)2.44803379
44Decreased lacrimation (HP:0000633)2.44550675
45Mixed hearing impairment (HP:0000410)2.43787011
46Atrophic scars (HP:0001075)2.43079611
47Cortical dysplasia (HP:0002539)2.42256794
48Onion bulb formation (HP:0003383)2.41309205
49Clumsiness (HP:0002312)2.41101303
50Hyperventilation (HP:0002883)2.38938624
51Abnormality of the phalanges of the 2nd finger (HP:0009541)2.38575578
52Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.37255522
53Dysmetria (HP:0001310)2.33924005
54Mild short stature (HP:0003502)2.33560380
55Trigonocephaly (HP:0000243)2.33093789
56Focal motor seizures (HP:0011153)2.31780373
57Buphthalmos (HP:0000557)2.31322574
58Abnormality of the 4th metacarpal (HP:0010012)2.30744779
59Intention tremor (HP:0002080)2.27901172
60Renal hypoplasia (HP:0000089)2.27794208
61Deformed tarsal bones (HP:0008119)2.23913249
62Aplasia/Hypoplasia of the sternum (HP:0006714)2.21869879
63Fibular hypoplasia (HP:0003038)2.21526047
64Anteriorly placed anus (HP:0001545)2.21483586
65Broad foot (HP:0001769)2.21252609
66Drooling (HP:0002307)2.20413456
67Optic nerve hypoplasia (HP:0000609)2.19637617
68Split foot (HP:0001839)2.19043073
69Myelomeningocele (HP:0002475)2.18871599
70Broad metatarsal (HP:0001783)2.17998665
71Hemivertebrae (HP:0002937)2.17607365
72Tibial bowing (HP:0002982)2.17079966
73Breech presentation (HP:0001623)2.16872168
74Hypoplasia of the iris (HP:0007676)2.16500770
75Shallow orbits (HP:0000586)2.16482551
76Atonic seizures (HP:0010819)2.15346404
77Ankle clonus (HP:0011448)2.11927897
78Turricephaly (HP:0000262)2.11747705
79Abnormality of dentin (HP:0010299)2.11551169
80Rib fusion (HP:0000902)2.10568378
81Neuroendocrine neoplasm (HP:0100634)2.10175592
82Heterochromia iridis (HP:0001100)2.09686446
83Genu recurvatum (HP:0002816)2.08417883
84Scanning speech (HP:0002168)2.08249026
85Absent septum pellucidum (HP:0001331)2.08026088
86Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.07937805
87Vertebral hypoplasia (HP:0008417)2.07937805
88Aplasia/Hypoplasia of the fibula (HP:0006492)2.07821778
89Soft skin (HP:0000977)2.07463129
90Oligodactyly (HP:0012165)2.05998513
91Gait imbalance (HP:0002141)2.05245039
92Abnormality of the lower motor neuron (HP:0002366)2.04723665
93Akinesia (HP:0002304)2.04601111
94Premature skin wrinkling (HP:0100678)2.03383794
95Cupped ear (HP:0000378)2.02980204
96White forelock (HP:0002211)2.02494529
97Adrenal hypoplasia (HP:0000835)2.00018915
98Omphalocele (HP:0001539)1.98921200
99Hypoplastic ischia (HP:0003175)1.98682677
100Hammertoe (HP:0001765)1.98231860
101Partial duplication of the phalanx of hand (HP:0009999)1.98167846
102Partial duplication of thumb phalanx (HP:0009944)1.97051698
103Excessive salivation (HP:0003781)1.96598126
104Arterial tortuosity (HP:0005116)1.96410121
105Hypoplastic left heart (HP:0004383)1.95036884
106Anophthalmia (HP:0000528)1.93579494
107Patchy hypopigmentation of hair (HP:0011365)1.92682617
108Abnormal eating behavior (HP:0100738)1.92407789
109Short tibia (HP:0005736)1.91454111
110Pancreatic fibrosis (HP:0100732)1.90848733
111Broad-based gait (HP:0002136)1.88572521
112Short hallux (HP:0010109)1.88534389
113Ulnar claw (HP:0001178)1.87368548
114Hemiparesis (HP:0001269)1.86970495
115Follicular hyperkeratosis (HP:0007502)1.86895236
116Postaxial hand polydactyly (HP:0001162)1.86682901
117Recurrent corneal erosions (HP:0000495)1.86399158
118Bronchomalacia (HP:0002780)1.85928382
119Anencephaly (HP:0002323)1.84059200
120Lower limb muscle weakness (HP:0007340)1.82665809
121Aplasia/Hypoplasia of the tibia (HP:0005772)1.81109611
122Microglossia (HP:0000171)1.80919960
123Pachygyria (HP:0001302)1.80135744
124Increased serum pyruvate (HP:0003542)1.79120581
125Abnormality of glycolysis (HP:0004366)1.79120581
126Absent frontal sinuses (HP:0002688)1.79013232
127Autoamputation (HP:0001218)1.78569477
128Broad long bones (HP:0005622)1.78568712
129Oligodactyly (hands) (HP:0001180)1.76666966
130Relative macrocephaly (HP:0004482)1.76473345
131Congenital primary aphakia (HP:0007707)1.76230181
132Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75941588
133Action tremor (HP:0002345)1.75100306
134Specific learning disability (HP:0001328)1.74703973
135Focal seizures (HP:0007359)1.74693307
136High anterior hairline (HP:0009890)1.74505523
137Medial flaring of the eyebrow (HP:0010747)1.74147698
138Postaxial foot polydactyly (HP:0001830)1.72562646
139Mitral regurgitation (HP:0001653)1.72193002
140Nasolacrimal duct obstruction (HP:0000579)1.71574990
141Hyperglycinemia (HP:0002154)1.71456304
142Abnormality of the septum pellucidum (HP:0007375)1.71183613
143Vaginal atresia (HP:0000148)1.70864645
144Long clavicles (HP:0000890)1.70486408
145Partial agenesis of the corpus callosum (HP:0001338)1.70189220
146Septo-optic dysplasia (HP:0100842)1.69874563
147Renal dysplasia (HP:0000110)1.69758785
148Keratoconus (HP:0000563)1.69449769
149Increased corneal curvature (HP:0100692)1.69449769
150Morphological abnormality of the inner ear (HP:0011390)1.68056074
151Abnormality of the nasolacrimal system (HP:0000614)1.66886124
152Neonatal short-limb short stature (HP:0008921)1.66350842
153Preaxial foot polydactyly (HP:0001841)1.66018628
154Genital tract atresia (HP:0001827)1.65384610
155Narrow nasal bridge (HP:0000446)1.65368174
156Papillary thyroid carcinoma (HP:0002895)1.65145978
157Meningocele (HP:0002435)1.64911967
158Stridor (HP:0010307)1.64660218
159Morphological abnormality of the middle ear (HP:0008609)1.64597012
160Conical tooth (HP:0000698)1.64573187
161Leukodystrophy (HP:0002415)1.64012079
162Cutaneous finger syndactyly (HP:0010554)1.63990426
163Aplasia/Hypoplasia of the hallux (HP:0008362)1.63792256
164Widely spaced teeth (HP:0000687)1.63653257
165Chin dimple (HP:0010751)1.63044829
166Long nose (HP:0003189)1.62881072
167Symphalangism affecting the phalanges of the hand (HP:0009773)1.62292799
168Generalized tonic-clonic seizures (HP:0002069)1.62174924
169Abnormality of the 2nd finger (HP:0004100)1.60744495
170Facial hemangioma (HP:0000329)1.60533165
171Vascular tortuosity (HP:0004948)1.60508693
172Hypophosphatemic rickets (HP:0004912)1.59168034
173Pheochromocytoma (HP:0002666)1.58906894
174Spastic paraparesis (HP:0002313)1.58423239

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.95766022
2OXSR13.76262833
3CASK3.45789314
4EPHA42.84772992
5DDR22.53568962
6BCR2.53203379
7MOS2.40787823
8CDK192.39602234
9EPHB12.33099992
10TNIK2.26624348
11FGFR22.09484711
12PKN12.03530430
13SIK21.97356143
14WNK41.97290040
15MET1.91821930
16WNK11.89158170
17MARK11.79982753
18NTRK11.78421104
19PRPF4B1.77408228
20PBK1.75498362
21CSNK1A1L1.66186135
22MAPKAPK51.64000890
23ROCK21.58317096
24CSNK1G31.54672407
25PNCK1.51725929
26UHMK11.49250400
27LIMK11.48144835
28FGR1.44414823
29NEK61.42028052
30ICK1.41310510
31NTRK21.40659882
32CSNK1G21.40401321
33PAK61.39385841
34MKNK21.38559001
35CSNK1G11.29018720
36CAMK2B1.26823074
37RPS6KA41.26248637
38PAK31.21456481
39WNK31.19500338
40PHKG11.17385382
41PHKG21.17385382
42WEE11.14688925
43PLK21.14042206
44NEK21.10318389
45MAP4K21.07889136
46TYRO31.04387358
47MAPK131.03827182
48SGK2231.03214651
49SGK4941.03214651
50EPHB21.03091349
51YES11.01809632
52CLK11.01471718
53NTRK31.00381901
54CDK51.00327893
55PRKCE0.95734939
56CDK140.95371751
57CAMK2A0.95231539
58CAMK2D0.94693948
59LATS20.90679480
60CDK150.83422460
61PRKD30.82361011
62NEK90.80984630
63CDK180.80820524
64BMPR1B0.78765364
65DYRK20.78079506
66PKN20.77348395
67CAMK2G0.74822464
68MARK20.74535340
69ERBB40.73806783
70CDK11A0.72859165
71CAMK1G0.71613473
72ERBB20.71610073
73DMPK0.71554604
74MAP3K40.69291914
75ERBB30.68305718
76TESK20.67065503
77ROCK10.64998166
78PTK2B0.64484955
79PRKCQ0.61953558
80DAPK20.61255186
81PIK3CA0.61240886
82PRKD10.60959161
83PRKCG0.60003741
84LATS10.58152116
85MUSK0.57505493
86PRKCH0.57212608
87FYN0.55401924
88ADRBK10.54752390
89ARAF0.54692646
90PDGFRB0.54165732
91MAPK70.53390243
92PINK10.53323128
93PAK20.52699256
94BMX0.52322757
95CSNK1D0.52300453
96SIK10.51834666
97SGK20.51183635
98MAP2K70.50763310
99MST40.50299255
100PRKG10.49042954
101MINK10.46620884
102EPHA30.46358621
103MAP3K100.45813624
104DYRK1A0.45682956
105TRPM70.45424475
106STK110.44564506
107MAPK150.44405381
108CSNK1A10.43867666
109PDGFRA0.43827815
110LMTK20.43078426
111CAMKK10.42856204
112IRAK20.42314822
113TRIM280.41925906
114MKNK10.41644055
115KSR10.40903953
116FGFR10.39665247
117MAPK100.39393344
118BRD40.39372273
119PRKCZ0.38862889
120DYRK1B0.38822156
121BCKDK0.37574899
122PDPK10.37258662
123KSR20.36615455
124CDK30.35809179
125MAP3K90.34270254
126INSR0.32876004
127NUAK10.32498304
128PRKDC0.27122398
129RPS6KA30.25571113
130CDC70.25534046
131STK38L0.25263989
132PRKACB0.24814324

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.04160756
2Steroid biosynthesis_Homo sapiens_hsa001003.66639703
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.05750947
4Fatty acid elongation_Homo sapiens_hsa000623.02682635
5Axon guidance_Homo sapiens_hsa043602.21933377
6Ether lipid metabolism_Homo sapiens_hsa005652.21916291
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06377916
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.03477305
9Nicotine addiction_Homo sapiens_hsa050331.84748514
10GABAergic synapse_Homo sapiens_hsa047271.79794845
11Glutamatergic synapse_Homo sapiens_hsa047241.78914488
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.67302957
13Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.63076119
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.58241038
15Morphine addiction_Homo sapiens_hsa050321.49065319
16Circadian entrainment_Homo sapiens_hsa047131.45684188
17Long-term depression_Homo sapiens_hsa047301.43936791
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40317731
19Serotonergic synapse_Homo sapiens_hsa047261.40242060
20Notch signaling pathway_Homo sapiens_hsa043301.40186223
21Sphingolipid metabolism_Homo sapiens_hsa006001.33990790
22Hedgehog signaling pathway_Homo sapiens_hsa043401.32347646
23Salivary secretion_Homo sapiens_hsa049701.30258657
24Adherens junction_Homo sapiens_hsa045201.29637010
25Basal cell carcinoma_Homo sapiens_hsa052171.25358603
26Sulfur metabolism_Homo sapiens_hsa009201.24539153
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.23246474
28ECM-receptor interaction_Homo sapiens_hsa045121.22964498
29Oxidative phosphorylation_Homo sapiens_hsa001901.22750803
30Cocaine addiction_Homo sapiens_hsa050301.21693225
31Renal cell carcinoma_Homo sapiens_hsa052111.21474826
32Propanoate metabolism_Homo sapiens_hsa006401.20807680
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16477899
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14511000
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11918998
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07752860
37Dopaminergic synapse_Homo sapiens_hsa047281.07481156
38Amphetamine addiction_Homo sapiens_hsa050311.06862716
39Tight junction_Homo sapiens_hsa045301.06401342
40Gastric acid secretion_Homo sapiens_hsa049711.06048145
41Renin secretion_Homo sapiens_hsa049241.05538784
42Melanogenesis_Homo sapiens_hsa049161.04902274
43Thyroid hormone synthesis_Homo sapiens_hsa049181.04065856
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02762558
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02561149
46Butanoate metabolism_Homo sapiens_hsa006501.02229281
47Alzheimers disease_Homo sapiens_hsa050101.01193480
48Wnt signaling pathway_Homo sapiens_hsa043101.00207049
49Gap junction_Homo sapiens_hsa045400.99552955
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96338728
51Cholinergic synapse_Homo sapiens_hsa047250.96080853
52Synaptic vesicle cycle_Homo sapiens_hsa047210.95465757
53Nitrogen metabolism_Homo sapiens_hsa009100.94955539
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91797616
55Ras signaling pathway_Homo sapiens_hsa040140.90168820
56Long-term potentiation_Homo sapiens_hsa047200.90020622
57Fatty acid biosynthesis_Homo sapiens_hsa000610.89676198
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.89489590
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.88713562
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87665760
61Collecting duct acid secretion_Homo sapiens_hsa049660.86737442
62Vibrio cholerae infection_Homo sapiens_hsa051100.86528613
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.86491430
64ErbB signaling pathway_Homo sapiens_hsa040120.85700737
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85229869
66Hippo signaling pathway_Homo sapiens_hsa043900.85205296
67Taste transduction_Homo sapiens_hsa047420.83826322
68MicroRNAs in cancer_Homo sapiens_hsa052060.82781365
69Ovarian steroidogenesis_Homo sapiens_hsa049130.80419771
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79507971
71Calcium signaling pathway_Homo sapiens_hsa040200.79135400
72Colorectal cancer_Homo sapiens_hsa052100.78272722
73Dorso-ventral axis formation_Homo sapiens_hsa043200.78210110
74Olfactory transduction_Homo sapiens_hsa047400.78095957
75Cardiac muscle contraction_Homo sapiens_hsa042600.77089059
76Prion diseases_Homo sapiens_hsa050200.76974219
77cAMP signaling pathway_Homo sapiens_hsa040240.76768936
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76329681
79Parkinsons disease_Homo sapiens_hsa050120.75350397
80Insulin secretion_Homo sapiens_hsa049110.74112905
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.73980041
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73685232
83Folate biosynthesis_Homo sapiens_hsa007900.72629688
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72095083
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72003815
86Linoleic acid metabolism_Homo sapiens_hsa005910.71842195
87Phototransduction_Homo sapiens_hsa047440.71342351
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71068449
89Oxytocin signaling pathway_Homo sapiens_hsa049210.70327276
90Dilated cardiomyopathy_Homo sapiens_hsa054140.68963387
91Endometrial cancer_Homo sapiens_hsa052130.68143397
92Protein export_Homo sapiens_hsa030600.67999899
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67659450
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66679282
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66634636
96Fatty acid metabolism_Homo sapiens_hsa012120.65541805
97Focal adhesion_Homo sapiens_hsa045100.65471635
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63802850
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.63272203
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63164317
101Pancreatic secretion_Homo sapiens_hsa049720.62497572
102Histidine metabolism_Homo sapiens_hsa003400.61515972
103Protein digestion and absorption_Homo sapiens_hsa049740.60908088
104Malaria_Homo sapiens_hsa051440.60533276
105Endocytosis_Homo sapiens_hsa041440.60437861
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59867766
107Vitamin B6 metabolism_Homo sapiens_hsa007500.59434828
108Rap1 signaling pathway_Homo sapiens_hsa040150.58423930
109GnRH signaling pathway_Homo sapiens_hsa049120.58332122
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56389549
111Choline metabolism in cancer_Homo sapiens_hsa052310.55644648
112Rheumatoid arthritis_Homo sapiens_hsa053230.55282840
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55155349
114Arginine and proline metabolism_Homo sapiens_hsa003300.54839497
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54564372
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53972605
117Melanoma_Homo sapiens_hsa052180.53533592
118PPAR signaling pathway_Homo sapiens_hsa033200.53408004
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53291699
120Pathways in cancer_Homo sapiens_hsa052000.53093213
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52993369
122Glioma_Homo sapiens_hsa052140.52710918
123Alcoholism_Homo sapiens_hsa050340.52197153
124Circadian rhythm_Homo sapiens_hsa047100.52160511
125Mineral absorption_Homo sapiens_hsa049780.51906543
126Estrogen signaling pathway_Homo sapiens_hsa049150.50513856
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49225038
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48886102
129Biosynthesis of amino acids_Homo sapiens_hsa012300.48543311
130MAPK signaling pathway_Homo sapiens_hsa040100.47775687
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47157463
132TGF-beta signaling pathway_Homo sapiens_hsa043500.46723799
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43549808
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43239815
135Oocyte meiosis_Homo sapiens_hsa041140.42319563

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