PTMAP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of mast cell activation (GO:0033004)5.98211803
2behavioral response to nicotine (GO:0035095)5.76599469
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.20623690
4ATP synthesis coupled proton transport (GO:0015986)5.20623690
5DNA deamination (GO:0045006)5.16323635
6response to pheromone (GO:0019236)5.06888482
7ribosomal small subunit assembly (GO:0000028)4.69207432
8mitochondrial respiratory chain complex I assembly (GO:0032981)4.51078641
9NADH dehydrogenase complex assembly (GO:0010257)4.51078641
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.51078641
11regulation of activation of Janus kinase activity (GO:0010533)4.22218008
12viral transcription (GO:0019083)4.21533739
13translational termination (GO:0006415)4.16028860
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.13112454
15chaperone-mediated protein transport (GO:0072321)3.89565132
16protein complex biogenesis (GO:0070271)3.83439775
17regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.75050405
18water-soluble vitamin biosynthetic process (GO:0042364)3.71697596
19positive regulation of T cell apoptotic process (GO:0070234)3.65712574
20protein neddylation (GO:0045116)3.63623680
21ribosomal small subunit biogenesis (GO:0042274)3.61108753
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.56353815
23exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.54990203
24nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.54631973
25translational elongation (GO:0006414)3.53644500
26protein targeting to ER (GO:0045047)3.52842249
27cotranslational protein targeting to membrane (GO:0006613)3.52523965
28mitochondrial respiratory chain complex assembly (GO:0033108)3.41801998
29rRNA modification (GO:0000154)3.39024748
30protein localization to endoplasmic reticulum (GO:0070972)3.38459099
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.36704952
32rRNA catabolic process (GO:0016075)3.36587220
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.34934336
34activated T cell proliferation (GO:0050798)3.24721726
35ribosomal large subunit biogenesis (GO:0042273)3.23567986
36GTP biosynthetic process (GO:0006183)3.23044973
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.22479507
38ncRNA 3-end processing (GO:0043628)3.21995611
39purine nucleoside triphosphate biosynthetic process (GO:0009145)3.13723361
40purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.12864624
41positive regulation of lymphocyte apoptotic process (GO:0070230)3.12789276
42ATP biosynthetic process (GO:0006754)3.09649777
43peptidyl-histidine modification (GO:0018202)3.08675982
44positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.08646979
45pyrimidine nucleobase catabolic process (GO:0006208)3.06692265
46maturation of SSU-rRNA (GO:0030490)3.02803380
47viral life cycle (GO:0019058)3.02562066
48cellular protein complex disassembly (GO:0043624)3.02254937
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.02201881
50electron transport chain (GO:0022900)3.02044762
51fucose catabolic process (GO:0019317)2.99603301
52L-fucose metabolic process (GO:0042354)2.99603301
53L-fucose catabolic process (GO:0042355)2.99603301
54preassembly of GPI anchor in ER membrane (GO:0016254)2.96667607
55respiratory electron transport chain (GO:0022904)2.95741511
56translation (GO:0006412)2.89212889
57rRNA methylation (GO:0031167)2.88026190
58cellular component biogenesis (GO:0044085)2.87807373
59pseudouridine synthesis (GO:0001522)2.87218732
60nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.86191874
61auditory receptor cell differentiation (GO:0042491)2.84152878
62regulation of isotype switching to IgG isotypes (GO:0048302)2.82841034
63regulation of transmission of nerve impulse (GO:0051969)2.82653417
64cytidine deamination (GO:0009972)2.81759906
65cytidine metabolic process (GO:0046087)2.81759906
66cytidine catabolic process (GO:0006216)2.81759906
67translational initiation (GO:0006413)2.81085322
68replication fork processing (GO:0031297)2.76588875
69negative regulation of B cell proliferation (GO:0030889)2.75015933
70ribonucleoside triphosphate biosynthetic process (GO:0009201)2.70848134
71ribonucleoprotein complex biogenesis (GO:0022613)2.69049035
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.68572835
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.68572835
74regulation of chronic inflammatory response (GO:0002676)2.68400687
75protein polyglutamylation (GO:0018095)2.67029938
76tRNA processing (GO:0008033)2.64734618
77somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64378003
78somatic hypermutation of immunoglobulin genes (GO:0016446)2.64378003
79negative regulation of phagocytosis (GO:0050765)2.63343349
80negative regulation of heart rate (GO:0010459)2.63150117
81phosphatidylserine acyl-chain remodeling (GO:0036150)2.62986937
82transcription elongation from RNA polymerase III promoter (GO:0006385)2.61833683
83termination of RNA polymerase III transcription (GO:0006386)2.61833683
84UTP biosynthetic process (GO:0006228)2.60877879
85resolution of meiotic recombination intermediates (GO:0000712)2.58839671
86piRNA metabolic process (GO:0034587)2.58608596
87negative regulation of organelle assembly (GO:1902116)2.58606131
88negative regulation of alpha-beta T cell activation (GO:0046636)2.58444385
89mast cell activation involved in immune response (GO:0002279)2.57574785
90mast cell degranulation (GO:0043303)2.57574785
91rRNA metabolic process (GO:0016072)2.56347865
92respiratory chain complex IV assembly (GO:0008535)2.54978669
93protein complex disassembly (GO:0043241)2.54099985
94maturation of 5.8S rRNA (GO:0000460)2.52604562
95organelle disassembly (GO:1903008)2.52544241
96nucleobase catabolic process (GO:0046113)2.51646378
97macromolecular complex disassembly (GO:0032984)2.51324898
98ncRNA catabolic process (GO:0034661)2.50684437
99pyrimidine ribonucleoside catabolic process (GO:0046133)2.49807439
100rRNA processing (GO:0006364)2.49744649

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.85499954
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.60988139
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.47885085
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.33203978
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.20875951
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.06315014
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.97666784
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.94322910
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.74750297
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69892424
11ZNF274_21170338_ChIP-Seq_K562_Hela2.50266878
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.43697997
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36376438
14IRF1_19129219_ChIP-ChIP_H3396_Human2.35484105
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21317961
16VDR_22108803_ChIP-Seq_LS180_Human2.17023856
17IGF1R_20145208_ChIP-Seq_DFB_Human2.12874465
18VDR_23849224_ChIP-Seq_CD4+_Human2.00360919
19FOXP3_21729870_ChIP-Seq_TREG_Human1.97345684
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.90010608
21ELK1_19687146_ChIP-ChIP_HELA_Human1.89921392
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73373724
23TP53_22573176_ChIP-Seq_HFKS_Human1.69587854
24EWS_26573619_Chip-Seq_HEK293_Human1.68035621
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57263761
26MYC_18940864_ChIP-ChIP_HL60_Human1.56525624
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.54623543
28TAF2_19829295_ChIP-Seq_ESCs_Human1.52070040
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51995062
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50749708
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49330508
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47058089
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43671600
34GATA3_21878914_ChIP-Seq_MCF-7_Human1.43592418
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43399487
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41758911
37EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.38675715
38ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35459910
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32546919
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.30944165
41REST_21632747_ChIP-Seq_MESCs_Mouse1.28813659
42GABP_19822575_ChIP-Seq_HepG2_Human1.28182804
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25888940
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25105220
45NANOG_20526341_ChIP-Seq_ESCs_Human1.24063189
46ERA_21632823_ChIP-Seq_H3396_Human1.22497667
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.16440382
48FUS_26573619_Chip-Seq_HEK293_Human1.14064060
49HOXB7_26014856_ChIP-Seq_BT474_Human1.13669921
50TDRD3_21172665_ChIP-Seq_MCF-7_Human1.13541159
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13275535
52XRN2_22483619_ChIP-Seq_HELA_Human1.12454962
53ER_23166858_ChIP-Seq_MCF-7_Human1.12370709
54NCOR_22424771_ChIP-Seq_293T_Human1.12342612
55AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12156288
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.11809068
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11809068
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11305890
59CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08332474
60RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07595899
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.06909816
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05397672
63CBP_20019798_ChIP-Seq_JUKART_Human1.05397672
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05126116
65MYC_19829295_ChIP-Seq_ESCs_Human1.04072093
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.03753257
67YY1_22570637_ChIP-Seq_MALME-3M_Human1.03302238
68TTF2_22483619_ChIP-Seq_HELA_Human1.02413387
69SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02396303
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02177161
71BCL6_27268052_Chip-Seq_Bcells_Human1.01840225
72AR_20517297_ChIP-Seq_VCAP_Human1.01672579
73ERG_20517297_ChIP-Seq_VCAP_Human1.00247898
74BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99391048
75IRF8_22096565_ChIP-ChIP_GC-B_Human0.98975321
76E2F4_17652178_ChIP-ChIP_JURKAT_Human0.98823104
77CIITA_25753668_ChIP-Seq_RAJI_Human0.98769456
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96782218
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96040228
80GBX2_23144817_ChIP-Seq_PC3_Human0.95350229
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94271625
82CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93713945
83GATA3_26560356_Chip-Seq_TH2_Human0.92361382
84STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.91247492
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91179655
86PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91101523
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.89702236
88SOX2_19829295_ChIP-Seq_ESCs_Human0.89128113
89NANOG_19829295_ChIP-Seq_ESCs_Human0.89128113
90ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89116256
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88879504
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88786868
93PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.88637119
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87688147
95EZH2_27294783_Chip-Seq_ESCs_Mouse0.86874104
96EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86831368
97PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86588841
98CBX2_27304074_Chip-Seq_ESCs_Mouse0.86312944
99THAP11_20581084_ChIP-Seq_MESCs_Mouse0.85805437
100EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85094488

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.36600358
2MP0009379_abnormal_foot_pigmentation2.98714834
3MP0008877_abnormal_DNA_methylation2.80687527
4MP0003646_muscle_fatigue2.65935139
5MP0003787_abnormal_imprinting2.62014485
6MP0001348_abnormal_lacrimal_gland2.45667120
7MP0005671_abnormal_response_to2.45517641
8MP0001986_abnormal_taste_sensitivity2.27969681
9MP0001968_abnormal_touch/_nociception2.23001272
10MP0008875_abnormal_xenobiotic_pharmacok2.17177405
11MP0003878_abnormal_ear_physiology2.13897477
12MP0005377_hearing/vestibular/ear_phenot2.13897477
13MP0004142_abnormal_muscle_tone2.12649594
14MP0002736_abnormal_nociception_after2.03217451
15MP0008872_abnormal_physiological_respon2.02578279
16MP0005423_abnormal_somatic_nervous1.98081434
17MP0004145_abnormal_muscle_electrophysio1.88652165
18MP0002163_abnormal_gland_morphology1.86092439
19MP0005646_abnormal_pituitary_gland1.74723464
20MP0000372_irregular_coat_pigmentation1.72929232
21MP0003880_abnormal_central_pattern1.69568026
22MP0001873_stomach_inflammation1.69401410
23MP0005551_abnormal_eye_electrophysiolog1.66989433
24MP0001485_abnormal_pinna_reflex1.62776197
25MP0000569_abnormal_digit_pigmentation1.61785270
26MP0002876_abnormal_thyroid_physiology1.58610463
27MP0002272_abnormal_nervous_system1.50496326
28MP0004885_abnormal_endolymph1.49459051
29MP0005174_abnormal_tail_pigmentation1.48483188
30MP0000685_abnormal_immune_system1.46300512
31MP0004742_abnormal_vestibular_system1.45569145
32MP0002102_abnormal_ear_morphology1.44302739
33MP0002277_abnormal_respiratory_mucosa1.43039182
34MP0004147_increased_porphyrin_level1.32953677
35MP0005075_abnormal_melanosome_morpholog1.31923823
36MP0003806_abnormal_nucleotide_metabolis1.30229617
37MP0008789_abnormal_olfactory_epithelium1.30051053
38MP0002735_abnormal_chemical_nociception1.29348568
39MP0003121_genomic_imprinting1.28815202
40MP0001835_abnormal_antigen_presentation1.26108681
41MP0005389_reproductive_system_phenotype1.24665703
42MP0001919_abnormal_reproductive_system1.24051584
43MP0002938_white_spotting1.22211043
44MP0002557_abnormal_social/conspecific_i1.21740750
45MP0000631_abnormal_neuroendocrine_gland1.21049618
46MP0004133_heterotaxia1.20778653
47MP0000015_abnormal_ear_pigmentation1.20103702
48MP0006072_abnormal_retinal_apoptosis1.19730724
49MP0003763_abnormal_thymus_physiology1.19212713
50MP0009046_muscle_twitch1.19126962
51MP0003283_abnormal_digestive_organ1.18550350
52MP0002638_abnormal_pupillary_reflex1.17082802
53MP0002733_abnormal_thermal_nociception1.16639143
54MP0001970_abnormal_pain_threshold1.15345096
55MP0006276_abnormal_autonomic_nervous1.15251770
56MP0009745_abnormal_behavioral_response1.15150575
57MP0005253_abnormal_eye_physiology1.14552573
58MP0006036_abnormal_mitochondrial_physio1.14234754
59MP0006035_abnormal_mitochondrial_morpho1.14189706
60MP0005387_immune_system_phenotype1.13563641
61MP0001790_abnormal_immune_system1.13563641
62MP0001905_abnormal_dopamine_level1.13279722
63MP0002095_abnormal_skin_pigmentation1.12815070
64MP0002160_abnormal_reproductive_system1.11245589
65MP0003122_maternal_imprinting1.11151077
66MP0005379_endocrine/exocrine_gland_phen1.10825410
67MP0001293_anophthalmia1.05812426
68MP0000049_abnormal_middle_ear1.05136964
69MP0005645_abnormal_hypothalamus_physiol1.03245074
70MP0001486_abnormal_startle_reflex1.01022606
71MP0003786_premature_aging0.99526030
72MP0005084_abnormal_gallbladder_morpholo0.97187170
73MP0002067_abnormal_sensory_capabilities0.97064105
74MP0001800_abnormal_humoral_immune0.93791055
75MP0002063_abnormal_learning/memory/cond0.92784505
76MP0008058_abnormal_DNA_repair0.92211127
77MP0003635_abnormal_synaptic_transmissio0.92190977
78MP0005410_abnormal_fertilization0.91574504
79MP0005499_abnormal_olfactory_system0.90557250
80MP0005394_taste/olfaction_phenotype0.90557250
81MP0001440_abnormal_grooming_behavior0.86047619
82MP0010386_abnormal_urinary_bladder0.84479049
83MP0003938_abnormal_ear_development0.84044446
84MP0001663_abnormal_digestive_system0.83626972
85MP0002138_abnormal_hepatobiliary_system0.82402821
86MP0002234_abnormal_pharynx_morphology0.82396451
87MP0002064_seizures0.82258972
88MP0002837_dystrophic_cardiac_calcinosis0.80666753
89MP0003123_paternal_imprinting0.78945247
90MP0003718_maternal_effect0.78692679
91MP0005195_abnormal_posterior_eye0.77442892
92MP0002572_abnormal_emotion/affect_behav0.77323340
93MP0002210_abnormal_sex_determination0.76296907
94MP0008775_abnormal_heart_ventricle0.74943418
95MP0003011_delayed_dark_adaptation0.73529053
96MP0003195_calcinosis0.72643682
97MP0001963_abnormal_hearing_physiology0.72628006
98MP0001929_abnormal_gametogenesis0.72312629
99MP0005408_hypopigmentation0.72083469
100MP0009764_decreased_sensitivity_to0.72047072

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.11001685
2Septo-optic dysplasia (HP:0100842)3.80389219
3Acute encephalopathy (HP:0006846)3.77303868
4Mitochondrial inheritance (HP:0001427)3.61186810
5Molar tooth sign on MRI (HP:0002419)3.58996414
6Abnormality of midbrain morphology (HP:0002418)3.58996414
7Abnormal mitochondria in muscle tissue (HP:0008316)3.58330477
8Absent rod-and cone-mediated responses on ERG (HP:0007688)3.55478669
9Progressive macrocephaly (HP:0004481)3.44023644
10Pancreatic cysts (HP:0001737)3.39520046
11Increased CSF lactate (HP:0002490)3.36012080
123-Methylglutaconic aciduria (HP:0003535)3.35734422
13Congenital stationary night blindness (HP:0007642)3.25062326
14Pancreatic fibrosis (HP:0100732)3.24390830
15Aplasia/Hypoplasia of the spleen (HP:0010451)3.14995264
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.09046688
17Asplenia (HP:0001746)3.08867193
18Increased hepatocellular lipid droplets (HP:0006565)2.96605140
19Abnormality of the renal cortex (HP:0011035)2.96397479
20Bile duct proliferation (HP:0001408)2.96216085
21Abnormal biliary tract physiology (HP:0012439)2.96216085
22Lipid accumulation in hepatocytes (HP:0006561)2.91336351
23Nephronophthisis (HP:0000090)2.90818240
24Abnormal rod and cone electroretinograms (HP:0008323)2.88811068
25Chronic hepatic failure (HP:0100626)2.88066635
26Testicular atrophy (HP:0000029)2.83267000
27Abnormal drinking behavior (HP:0030082)2.75483908
28Polydipsia (HP:0001959)2.75483908
29Cerebral edema (HP:0002181)2.73947636
30Pendular nystagmus (HP:0012043)2.58809216
31IgG deficiency (HP:0004315)2.55732720
32Renal Fanconi syndrome (HP:0001994)2.55111423
33Hepatocellular necrosis (HP:0001404)2.53774483
34Supernumerary spleens (HP:0009799)2.52362762
35Colon cancer (HP:0003003)2.45596087
36True hermaphroditism (HP:0010459)2.44258058
37Abolished electroretinogram (ERG) (HP:0000550)2.41298413
38Absent septum pellucidum (HP:0001331)2.40987329
39Abnormality of the renal medulla (HP:0100957)2.40545461
40Reticulocytopenia (HP:0001896)2.39378292
41Tubular atrophy (HP:0000092)2.36130009
42Parakeratosis (HP:0001036)2.34617698
43Abnormality of cells of the erythroid lineage (HP:0012130)2.32466056
44Renal cortical cysts (HP:0000803)2.31253934
45Optic disc pallor (HP:0000543)2.29857113
46Increased serum lactate (HP:0002151)2.29786370
47Optic nerve hypoplasia (HP:0000609)2.27631062
48Medial flaring of the eyebrow (HP:0010747)2.25669028
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.24837332
50Hyperglycinemia (HP:0002154)2.23829688
51Agitation (HP:0000713)2.22047679
52Type II lissencephaly (HP:0007260)2.20886631
53Methylmalonic aciduria (HP:0012120)2.20323686
54Hepatic necrosis (HP:0002605)2.20281991
55Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.17988428
56Cystic liver disease (HP:0006706)2.15145848
57Macrocytic anemia (HP:0001972)2.14766682
58Dyschromatopsia (HP:0007641)2.14642268
59Lissencephaly (HP:0001339)2.13979203
60Methylmalonic acidemia (HP:0002912)2.13815695
61Abnormality of the pons (HP:0007361)2.13676242
62Abnormality of the labia minora (HP:0012880)2.11991579
63Sclerocornea (HP:0000647)2.11238580
64Stomatitis (HP:0010280)2.06330440
65Congenital hepatic fibrosis (HP:0002612)2.02663376
66Lactic acidosis (HP:0003128)2.02381971
67Rib fusion (HP:0000902)2.01150142
68Pachygyria (HP:0001302)2.00996531
69Growth hormone deficiency (HP:0000824)2.00745693
70Abnormality of the septum pellucidum (HP:0007375)1.96503625
71Lethargy (HP:0001254)1.95295951
72Abnormal number of erythroid precursors (HP:0012131)1.90220218
73Adrenal hypoplasia (HP:0000835)1.90108384
74Attenuation of retinal blood vessels (HP:0007843)1.86385720
75Postaxial foot polydactyly (HP:0001830)1.85565714
76Impulsivity (HP:0100710)1.84601986
77Decreased central vision (HP:0007663)1.84520679
78Increased intramyocellular lipid droplets (HP:0012240)1.84148808
79Exertional dyspnea (HP:0002875)1.82201677
80Dynein arm defect of respiratory motile cilia (HP:0012255)1.81239189
81Absent/shortened dynein arms (HP:0200106)1.81239189
82Absent thumb (HP:0009777)1.79640905
83Ketosis (HP:0001946)1.76781621
84Status epilepticus (HP:0002133)1.75808303
85Polyuria (HP:0000103)1.75461702
86Severe combined immunodeficiency (HP:0004430)1.74863471
87Sensory axonal neuropathy (HP:0003390)1.72160791
88Focal motor seizures (HP:0011153)1.71819600
89Tubulointerstitial nephritis (HP:0001970)1.69322560
90Oligodactyly (hands) (HP:0001180)1.68857251
91Decreased activity of mitochondrial respiratory chain (HP:0008972)1.68488633
92Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.68488633
93Respiratory failure (HP:0002878)1.67509969
94Exercise intolerance (HP:0003546)1.66953598
95Hypoplasia of the pons (HP:0012110)1.66714356
96Leukodystrophy (HP:0002415)1.66667514
97Severe visual impairment (HP:0001141)1.64079462
98Constricted visual fields (HP:0001133)1.63359717
99Prostate neoplasm (HP:0100787)1.62418816
100Increased muscle lipid content (HP:0009058)1.61696340

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.95395825
2MAP4K23.60851245
3WNK42.82637864
4ADRBK22.61116511
5NUAK12.58585828
6VRK22.58183471
7LIMK12.55086794
8BCKDK2.37794544
9STK392.33878057
10ZAK2.31851449
11FES2.19527105
12MAP4K12.10559908
13DYRK22.09412825
14GRK12.02062461
15MST41.99382458
16TAF11.80687211
17CAMKK21.73347420
18OXSR11.71944774
19MAP3K111.69455884
20CDK81.59569751
21TLK11.49557951
22TRIM281.42706022
23PINK11.37652316
24CDC71.36546052
25FRK1.33538620
26CASK1.32119593
27BRSK11.24326508
28TIE11.22833667
29NEK11.20496674
30VRK11.18653559
31EIF2AK31.17087138
32SRPK11.12698122
33CAMKK11.07632704
34MAP2K71.07577798
35CDK191.05712722
36TNK20.99032884
37PAK30.98129261
38TNIK0.95596047
39TYRO30.94112769
40STK160.93948225
41PNCK0.93379911
42EPHA40.90521023
43PRKCQ0.88891652
44IKBKB0.86687325
45NME10.84455346
46CDC42BPA0.80654219
47LMTK20.78906950
48MAPKAPK50.78397661
49CAMK10.75327754
50BMPR1B0.72651640
51CSNK1G20.72125240
52PLK30.72116506
53PRKCG0.71637032
54PTK60.71525591
55AURKA0.68679284
56MKNK10.68554758
57GRK50.66939298
58TAOK30.61276770
59CSNK1G30.59917332
60ADRBK10.58424525
61ATR0.57314507
62KDR0.57029165
63CSNK2A20.56809286
64INSRR0.55575722
65PHKG20.53835707
66PHKG10.53835707
67CSNK1A1L0.52071636
68PRKCI0.51958826
69PLK40.51081358
70MKNK20.50590708
71EIF2AK20.50031107
72CSNK1A10.49311893
73PLK10.49252578
74DAPK10.47742719
75HIPK20.47187077
76KIT0.46940858
77MAPKAPK30.46701820
78SYK0.46329000
79EIF2AK10.44478952
80NME20.44398673
81CSNK2A10.44098734
82DYRK30.44091008
83LYN0.43324869
84RPS6KA50.43215677
85MAPK130.42813569
86BRSK20.42504756
87DAPK20.42240714
88WNK30.41413107
89ALK0.40384560
90PRKACA0.40031308
91CSNK1E0.39428627
92ITK0.39300590
93DAPK30.38499218
94LRRK20.34870236
95AURKB0.34466538
96PRKCA0.33240261
97PLK20.32814975
98CAMK1D0.31273250
99PIK3CA0.31095675
100CLK10.30352062

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.89134278
2Oxidative phosphorylation_Homo sapiens_hsa001903.21579606
3Parkinsons disease_Homo sapiens_hsa050122.72947078
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.50567006
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.42102329
6Proteasome_Homo sapiens_hsa030502.37832274
7Homologous recombination_Homo sapiens_hsa034402.33351681
8Linoleic acid metabolism_Homo sapiens_hsa005912.29125330
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.26609269
10RNA polymerase_Homo sapiens_hsa030202.09941986
11Asthma_Homo sapiens_hsa053102.09180046
12Protein export_Homo sapiens_hsa030602.08364275
13Caffeine metabolism_Homo sapiens_hsa002321.94085840
14Allograft rejection_Homo sapiens_hsa053301.90998848
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.89791887
16Autoimmune thyroid disease_Homo sapiens_hsa053201.89022369
17Primary immunodeficiency_Homo sapiens_hsa053401.83222577
18Huntingtons disease_Homo sapiens_hsa050161.81898405
19Basal transcription factors_Homo sapiens_hsa030221.80645952
20RNA degradation_Homo sapiens_hsa030181.79184711
21Cardiac muscle contraction_Homo sapiens_hsa042601.73830173
22Phototransduction_Homo sapiens_hsa047441.71153998
23Alzheimers disease_Homo sapiens_hsa050101.65699902
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65566345
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62447118
26Fanconi anemia pathway_Homo sapiens_hsa034601.57895040
27Propanoate metabolism_Homo sapiens_hsa006401.55570892
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54433349
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44525520
30Pyrimidine metabolism_Homo sapiens_hsa002401.41059137
31Mismatch repair_Homo sapiens_hsa034301.36600599
32One carbon pool by folate_Homo sapiens_hsa006701.34603842
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33808889
34Graft-versus-host disease_Homo sapiens_hsa053321.33367672
35Nicotine addiction_Homo sapiens_hsa050331.32678330
36Sulfur relay system_Homo sapiens_hsa041221.30917599
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30298504
38Nucleotide excision repair_Homo sapiens_hsa034201.29296326
39Nitrogen metabolism_Homo sapiens_hsa009101.26754132
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26350278
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14863246
42Ether lipid metabolism_Homo sapiens_hsa005651.13674233
43Arachidonic acid metabolism_Homo sapiens_hsa005901.12883033
44Type I diabetes mellitus_Homo sapiens_hsa049401.09976928
45DNA replication_Homo sapiens_hsa030301.06225319
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04928565
47Peroxisome_Homo sapiens_hsa041461.03897556
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99920246
49Regulation of autophagy_Homo sapiens_hsa041400.93728098
50Olfactory transduction_Homo sapiens_hsa047400.92952242
51Purine metabolism_Homo sapiens_hsa002300.91238361
52Steroid biosynthesis_Homo sapiens_hsa001000.90686653
53Butanoate metabolism_Homo sapiens_hsa006500.89367483
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89338461
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.85096149
56Non-homologous end-joining_Homo sapiens_hsa034500.84335296
57RNA transport_Homo sapiens_hsa030130.84266259
58Sulfur metabolism_Homo sapiens_hsa009200.80599595
59Spliceosome_Homo sapiens_hsa030400.79454516
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79172695
61Antigen processing and presentation_Homo sapiens_hsa046120.77230980
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76683372
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75872263
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73805136
65Base excision repair_Homo sapiens_hsa034100.69076246
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67964981
67Fat digestion and absorption_Homo sapiens_hsa049750.67732884
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.64473262
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64433444
70Metabolic pathways_Homo sapiens_hsa011000.63133597
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.61162726
72Tryptophan metabolism_Homo sapiens_hsa003800.56326502
73Retinol metabolism_Homo sapiens_hsa008300.56131135
74Chemical carcinogenesis_Homo sapiens_hsa052040.55823822
75Morphine addiction_Homo sapiens_hsa050320.55156755
76Hematopoietic cell lineage_Homo sapiens_hsa046400.54161644
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52282291
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47036803
79Rheumatoid arthritis_Homo sapiens_hsa053230.45096168
80Folate biosynthesis_Homo sapiens_hsa007900.44182762
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42604477
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.41606800
83Systemic lupus erythematosus_Homo sapiens_hsa053220.40608386
84Taste transduction_Homo sapiens_hsa047420.39905578
85Glutathione metabolism_Homo sapiens_hsa004800.39579485
86Glycerolipid metabolism_Homo sapiens_hsa005610.39527095
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39104126
88beta-Alanine metabolism_Homo sapiens_hsa004100.38189023
89GABAergic synapse_Homo sapiens_hsa047270.35432034
90Selenocompound metabolism_Homo sapiens_hsa004500.35427677
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.34519568
92Ovarian steroidogenesis_Homo sapiens_hsa049130.32465184
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31896968
94Viral myocarditis_Homo sapiens_hsa054160.31711147
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31329899
96Salivary secretion_Homo sapiens_hsa049700.30491582
97Vitamin digestion and absorption_Homo sapiens_hsa049770.30337954
98Glutamatergic synapse_Homo sapiens_hsa047240.24965899
99T cell receptor signaling pathway_Homo sapiens_hsa046600.24832501
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.23840545

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