PTMAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)7.40048502
2behavioral response to nicotine (GO:0035095)7.03743234
3pyrimidine nucleobase catabolic process (GO:0006208)5.73865241
4maturation of SSU-rRNA (GO:0030490)5.11677197
5regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.99097171
6adaptation of signaling pathway (GO:0023058)4.86397095
7regulation of cilium movement (GO:0003352)4.59189210
8nucleobase catabolic process (GO:0046113)4.57551106
9regulation of microtubule-based movement (GO:0060632)4.42570248
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.32554349
11spinal cord motor neuron differentiation (GO:0021522)4.27830460
12short-term memory (GO:0007614)4.26794248
13adult walking behavior (GO:0007628)4.22506184
14neuronal action potential propagation (GO:0019227)4.20377452
15positive regulation of sodium ion transmembrane transporter activity (GO:2000651)4.17451727
16positive regulation of filopodium assembly (GO:0051491)4.03284581
17postsynaptic membrane organization (GO:0001941)4.01647847
18head development (GO:0060322)4.00464321
19inner ear receptor cell differentiation (GO:0060113)3.92568423
20calcium ion-dependent exocytosis (GO:0017156)3.89940646
21auditory behavior (GO:0031223)3.89787801
22positive regulation of sodium ion transmembrane transport (GO:1902307)3.88579831
23ncRNA catabolic process (GO:0034661)3.83416616
24regulation of calcium ion-dependent exocytosis (GO:0017158)3.79054385
25regulation of synapse maturation (GO:0090128)3.75612578
26ear development (GO:0043583)3.74432001
27establishment of mitochondrion localization (GO:0051654)3.74354601
28mitochondrion transport along microtubule (GO:0047497)3.62204449
29establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.62204449
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.58122509
31mechanosensory behavior (GO:0007638)3.57897930
32synaptic transmission, cholinergic (GO:0007271)3.55692699
33cerebral cortex radially oriented cell migration (GO:0021799)3.54760821
34photoreceptor cell maintenance (GO:0045494)3.50579375
35cell differentiation in spinal cord (GO:0021515)3.48550187
36positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.47890575
37neurofilament cytoskeleton organization (GO:0060052)3.43358821
38layer formation in cerebral cortex (GO:0021819)3.35466112
39adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.34519941
40regulation of dopamine secretion (GO:0014059)3.21575424
41cell-cell junction maintenance (GO:0045217)3.20889047
42response to pheromone (GO:0019236)3.20767293
43ribosomal small subunit biogenesis (GO:0042274)3.16464681
44regulation of filopodium assembly (GO:0051489)3.14039667
45membrane depolarization during action potential (GO:0086010)3.12283071
46dopamine receptor signaling pathway (GO:0007212)3.11907080
47mechanoreceptor differentiation (GO:0042490)3.11426888
48synapse assembly (GO:0007416)3.07378301
49transmission of nerve impulse (GO:0019226)3.06017701
50membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.05120381
51positive regulation of synapse maturation (GO:0090129)3.01402491
52embryonic skeletal joint morphogenesis (GO:0060272)3.01031167
53RNA localization (GO:0006403)2.99873927
54regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.92891229
55response to auditory stimulus (GO:0010996)2.89163389
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.86989281
57vocalization behavior (GO:0071625)2.84990559
58chaperone-mediated protein transport (GO:0072321)2.84873816
59post-embryonic morphogenesis (GO:0009886)2.82018124
60positive regulation of neurotransmitter transport (GO:0051590)2.81286907
61membrane repolarization during action potential (GO:0086011)2.79728028
62negative regulation of cytosolic calcium ion concentration (GO:0051481)2.78605379
63positive regulation of gastrulation (GO:2000543)2.78076352
64cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.77871193
65presynaptic membrane assembly (GO:0097105)2.77154128
66axoneme assembly (GO:0035082)2.74563164
67neuronal action potential (GO:0019228)2.74314513
68negative regulation of appetite (GO:0032099)2.73630194
69negative regulation of response to food (GO:0032096)2.73630194
70synaptic vesicle maturation (GO:0016188)2.73184446
71neuromuscular process controlling posture (GO:0050884)2.73073008
72negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.72897286
73membrane repolarization (GO:0086009)2.71459110
74anterograde axon cargo transport (GO:0008089)2.71344108
75epithelial cilium movement (GO:0003351)2.70906158
76mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.70564962
77regulation of acrosome reaction (GO:0060046)2.69988126
78mitochondrion distribution (GO:0048311)2.69897770
79regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.67177702
80protein peptidyl-prolyl isomerization (GO:0000413)2.63158921
81positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.62901145
82positive regulation of potassium ion transmembrane transport (GO:1901381)2.61629937
83neuron fate commitment (GO:0048663)2.61143956
84positive regulation of protein homooligomerization (GO:0032464)2.57505498
85cell differentiation in hindbrain (GO:0021533)2.57186174
86cell junction maintenance (GO:0034331)2.55705542
87protein localization to synapse (GO:0035418)2.54758221
88neuromuscular synaptic transmission (GO:0007274)2.53442696
89regulation of action potential (GO:0098900)2.53316081
90regulation of respiratory system process (GO:0044065)2.53237919
91cerebellar Purkinje cell differentiation (GO:0021702)2.52618357
92spinal cord development (GO:0021510)2.48454395
93nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.48178878
94clathrin coat assembly (GO:0048268)2.47900553
95regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.46739679
96regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.46739679
97ATP synthesis coupled proton transport (GO:0015986)2.45897198
98energy coupled proton transport, down electrochemical gradient (GO:0015985)2.45897198
99membrane hyperpolarization (GO:0060081)2.44711533
100retina layer formation (GO:0010842)2.44573637

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.75906474
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.73981964
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.82805013
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.97601512
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.89923287
6REST_21632747_ChIP-Seq_MESCs_Mouse2.63323291
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.52999686
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.38475221
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37172142
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.32750247
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.28326614
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.18884387
13REST_18959480_ChIP-ChIP_MESCs_Mouse2.15317737
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.09017398
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08631846
16EZH2_27294783_Chip-Seq_ESCs_Mouse1.95274795
17SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95143821
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.94685530
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.94685530
20CBX2_27304074_Chip-Seq_ESCs_Mouse1.90896670
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.88722498
22VDR_22108803_ChIP-Seq_LS180_Human1.88311331
23IGF1R_20145208_ChIP-Seq_DFB_Human1.80830201
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79806643
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.76217494
26ZNF274_21170338_ChIP-Seq_K562_Hela1.72585402
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67097448
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63202123
29RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.62691053
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58971773
31SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.57336794
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.54123906
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51586624
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.50566812
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.42822679
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41395646
37RNF2_27304074_Chip-Seq_NSC_Mouse1.41392396
38ETV2_25802403_ChIP-Seq_MESCs_Mouse1.40277585
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33050671
40RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32986957
41MYC_19829295_ChIP-Seq_ESCs_Human1.31106791
42EWS_26573619_Chip-Seq_HEK293_Human1.30526611
43CTCF_27219007_Chip-Seq_Bcells_Human1.28956085
44GBX2_23144817_ChIP-Seq_PC3_Human1.28604432
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.27788362
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27741652
47GATA1_26923725_Chip-Seq_HPCs_Mouse1.27388777
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27256140
49DROSHA_22980978_ChIP-Seq_HELA_Human1.27053108
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26979877
51IRF1_19129219_ChIP-ChIP_H3396_Human1.25038399
52WDR5_24793694_ChIP-Seq_LNCAP_Human1.24669204
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23713875
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22061230
55CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21842186
56TP53_20018659_ChIP-ChIP_R1E_Mouse1.21017899
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20494204
58P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20456281
59TAF2_19829295_ChIP-Seq_ESCs_Human1.19690515
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19404484
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.19126674
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19063005
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.16890515
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10390487
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09406026
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08398297
67ERA_21632823_ChIP-Seq_H3396_Human1.08328112
68P300_19829295_ChIP-Seq_ESCs_Human1.08321397
69OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06203007
70RUNX2_22187159_ChIP-Seq_PCA_Human1.05056795
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04366984
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04105576
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03106454
74SOX2_21211035_ChIP-Seq_LN229_Human1.02109311
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02030373
76TP53_22573176_ChIP-Seq_HFKS_Human1.01503319
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00397822
78SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.99418995
79CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98598058
80SMAD4_21799915_ChIP-Seq_A2780_Human0.97380455
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97156103
82KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96999073
83OCT4_20526341_ChIP-Seq_ESCs_Human0.96929465
84SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96422748
85KLF4_19829295_ChIP-Seq_ESCs_Human0.94676805
86SMAD3_21741376_ChIP-Seq_ESCs_Human0.93725756
87TAL1_26923725_Chip-Seq_HPCs_Mouse0.92230870
88BCL6_27268052_Chip-Seq_Bcells_Human0.90739776
89SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89446910
90NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.89072770
91AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88296628
92RAC3_21632823_ChIP-Seq_H3396_Human0.88062556
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.87979266
94TCF4_23295773_ChIP-Seq_U87_Human0.86478542
95RXR_22108803_ChIP-Seq_LS180_Human0.86454345
96P68_20966046_ChIP-Seq_HELA_Human0.86173915
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85558286
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85458227
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85458227
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.85454005

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting3.29353665
2MP0006292_abnormal_olfactory_placode3.18805811
3MP0003787_abnormal_imprinting3.18538219
4MP0003879_abnormal_hair_cell3.06657585
5MP0001485_abnormal_pinna_reflex3.02877822
6MP0003122_maternal_imprinting2.93477415
7MP0004742_abnormal_vestibular_system2.79113473
8MP0002638_abnormal_pupillary_reflex2.56131053
9MP0004885_abnormal_endolymph2.55832751
10MP0008789_abnormal_olfactory_epithelium2.50601807
11MP0003878_abnormal_ear_physiology2.45236075
12MP0005377_hearing/vestibular/ear_phenot2.45236075
13MP0004859_abnormal_synaptic_plasticity2.38897982
14MP0005394_taste/olfaction_phenotype2.36620506
15MP0005499_abnormal_olfactory_system2.36620506
16MP0001986_abnormal_taste_sensitivity2.33172798
17MP0001529_abnormal_vocalization2.23990628
18MP0003635_abnormal_synaptic_transmissio2.21065130
19MP0002734_abnormal_mechanical_nocicepti2.19408522
20MP0008877_abnormal_DNA_methylation2.08587679
21MP0001968_abnormal_touch/_nociception2.00836521
22MP0009745_abnormal_behavioral_response2.00589119
23MP0006276_abnormal_autonomic_nervous1.98629180
24MP0004270_analgesia1.97841138
25MP0003121_genomic_imprinting1.96186443
26MP0002272_abnormal_nervous_system1.92341785
27MP0001984_abnormal_olfaction1.90096063
28MP0004145_abnormal_muscle_electrophysio1.85846682
29MP0005646_abnormal_pituitary_gland1.82635097
30MP0005423_abnormal_somatic_nervous1.81588044
31MP0005551_abnormal_eye_electrophysiolog1.81495597
32MP0003880_abnormal_central_pattern1.78433035
33MP0002876_abnormal_thyroid_physiology1.75670159
34MP0002163_abnormal_gland_morphology1.71473009
35MP0002063_abnormal_learning/memory/cond1.67255779
36MP0002067_abnormal_sensory_capabilities1.60521246
37MP0002822_catalepsy1.60215147
38MP0001970_abnormal_pain_threshold1.52267169
39MP0002837_dystrophic_cardiac_calcinosis1.52239306
40MP0004142_abnormal_muscle_tone1.51160038
41MP0002160_abnormal_reproductive_system1.49392203
42MP0002064_seizures1.47690556
43MP0002572_abnormal_emotion/affect_behav1.46380650
44MP0009046_muscle_twitch1.45257006
45MP0000631_abnormal_neuroendocrine_gland1.44015591
46MP0002557_abnormal_social/conspecific_i1.42518889
47MP0002736_abnormal_nociception_after1.40545433
48MP0002735_abnormal_chemical_nociception1.38193403
49MP0002733_abnormal_thermal_nociception1.34127166
50MP0004133_heterotaxia1.31331416
51MP0002882_abnormal_neuron_morphology1.29958682
52MP0001486_abnormal_startle_reflex1.29915105
53MP0000778_abnormal_nervous_system1.28961674
54MP0001293_anophthalmia1.27880795
55MP0003942_abnormal_urinary_system1.26578063
56MP0002752_abnormal_somatic_nervous1.24875429
57MP0004130_abnormal_muscle_cell1.22857112
58MP0001963_abnormal_hearing_physiology1.22632879
59MP0003646_muscle_fatigue1.21840879
60MP0005187_abnormal_penis_morphology1.21700513
61MP0000049_abnormal_middle_ear1.21534598
62MP0001440_abnormal_grooming_behavior1.19747504
63MP0004043_abnormal_pH_regulation1.18727743
64MP0003011_delayed_dark_adaptation1.17168992
65MP0001188_hyperpigmentation1.13016906
66MP0000955_abnormal_spinal_cord1.12514402
67MP0003195_calcinosis1.12296598
68MP0001348_abnormal_lacrimal_gland1.09399242
69MP0005389_reproductive_system_phenotype1.08349088
70MP0000026_abnormal_inner_ear1.04646504
71MP0008875_abnormal_xenobiotic_pharmacok0.99137490
72MP0010386_abnormal_urinary_bladder0.97032543
73MP0002909_abnormal_adrenal_gland0.95327267
74MP0000372_irregular_coat_pigmentation0.94562668
75MP0002751_abnormal_autonomic_nervous0.94124703
76MP0005195_abnormal_posterior_eye0.93033838
77MP0009379_abnormal_foot_pigmentation0.92656389
78MP0002229_neurodegeneration0.90820596
79MP0002184_abnormal_innervation0.90572368
80MP0001905_abnormal_dopamine_level0.90431240
81MP0000427_abnormal_hair_cycle0.89325195
82MP0002938_white_spotting0.88870265
83MP0002152_abnormal_brain_morphology0.87478341
84MP0005386_behavior/neurological_phenoty0.86874316
85MP0004924_abnormal_behavior0.86874316
86MP0002102_abnormal_ear_morphology0.85116463
87MP0005379_endocrine/exocrine_gland_phen0.84664905
88MP0004811_abnormal_neuron_physiology0.84514957
89MP0009384_cardiac_valve_regurgitation0.82193544
90MP0006072_abnormal_retinal_apoptosis0.81898915
91MP0005253_abnormal_eye_physiology0.81615156
92MP0001919_abnormal_reproductive_system0.80736702
93MP0005645_abnormal_hypothalamus_physiol0.76600097
94MP0009053_abnormal_anal_canal0.75016520
95MP0000230_abnormal_systemic_arterial0.74082652
96MP0002066_abnormal_motor_capabilities/c0.72747830
97MP0001765_abnormal_ion_homeostasis0.71016536
98MP0009250_abnormal_appendicular_skeleto0.69225290
99MP0003136_yellow_coat_color0.66596025
100MP0005410_abnormal_fertilization0.65458600

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.21460984
2Agitation (HP:0000713)3.97466493
3Broad distal phalanx of finger (HP:0009836)3.56179424
4Myokymia (HP:0002411)3.49416376
5Broad-based gait (HP:0002136)3.44756350
6Congenital stationary night blindness (HP:0007642)3.37140792
7Volvulus (HP:0002580)3.35823271
8Polyphagia (HP:0002591)3.31113857
9Limb dystonia (HP:0002451)3.25196641
10Retinal atrophy (HP:0001105)3.13844427
11Hyperthyroidism (HP:0000836)3.08674831
12Abnormality of midbrain morphology (HP:0002418)3.03816169
13Molar tooth sign on MRI (HP:0002419)3.03816169
14Bilateral microphthalmos (HP:0007633)3.01232770
15Abnormality of the renal cortex (HP:0011035)2.98793745
16Oligodactyly (hands) (HP:0001180)2.94433325
17Fetal akinesia sequence (HP:0001989)2.92811498
18Acute necrotizing encephalopathy (HP:0006965)2.91093256
19Hyperventilation (HP:0002883)2.85503477
20Polydipsia (HP:0001959)2.84785198
21Abnormal drinking behavior (HP:0030082)2.84785198
22Reticulocytopenia (HP:0001896)2.78741100
23Hepatocellular necrosis (HP:0001404)2.76908667
24Chronic hepatic failure (HP:0100626)2.74239269
25Focal seizures (HP:0007359)2.73441001
26Aplasia/Hypoplasia of the sternum (HP:0006714)2.69236114
27Morphological abnormality of the middle ear (HP:0008609)2.61951986
28Abnormality of the pubic bones (HP:0003172)2.60437613
29Abnormal mitochondria in muscle tissue (HP:0008316)2.59420454
30Absent rod-and cone-mediated responses on ERG (HP:0007688)2.59239233
31Hyperphosphatemia (HP:0002905)2.50861776
32Pendular nystagmus (HP:0012043)2.48290509
33Drooling (HP:0002307)2.47397809
34Amblyopia (HP:0000646)2.45844198
35Ectopic kidney (HP:0000086)2.45574346
36Increased CSF lactate (HP:0002490)2.40490110
37Mitochondrial inheritance (HP:0001427)2.39821148
38Restlessness (HP:0000711)2.37466088
39Pancreatic cysts (HP:0001737)2.36490606
40Cutaneous finger syndactyly (HP:0010554)2.35859100
41Abnormality of the renal medulla (HP:0100957)2.32701589
42Pancreatic fibrosis (HP:0100732)2.31789532
43Hepatic necrosis (HP:0002605)2.31483023
443-Methylglutaconic aciduria (HP:0003535)2.29855641
45Colon cancer (HP:0003003)2.29120514
46Protruding tongue (HP:0010808)2.28911969
47Nephronophthisis (HP:0000090)2.28908184
48Progressive macrocephaly (HP:0004481)2.28276341
49Anophthalmia (HP:0000528)2.25558689
50Excessive salivation (HP:0003781)2.24115500
51Gait imbalance (HP:0002141)2.23826606
52Abnormal rod and cone electroretinograms (HP:0008323)2.20558927
53Type II lissencephaly (HP:0007260)2.19463476
54Acute encephalopathy (HP:0006846)2.19462402
55Aplasia/Hypoplasia of the patella (HP:0006498)2.17423857
56Bifid tongue (HP:0010297)2.16199137
57Patellar aplasia (HP:0006443)2.15608330
58Vaginal atresia (HP:0000148)2.14065082
59Epileptic encephalopathy (HP:0200134)2.13365471
60Abnormality of DNA repair (HP:0003254)2.12215341
61Adrenal hypoplasia (HP:0000835)2.11601174
62Polyuria (HP:0000103)2.10348739
63Genital tract atresia (HP:0001827)2.06668404
64Abnormality of the aortic arch (HP:0012303)2.05359117
65Renal cortical cysts (HP:0000803)2.03289263
66Hemiplegia (HP:0002301)2.02282076
67Thyroid-stimulating hormone excess (HP:0002925)2.01270327
68Cutaneous syndactyly (HP:0012725)2.01128130
69Enlarged penis (HP:0000040)2.00423484
70Absent eyebrow (HP:0002223)1.96575674
71Retinitis pigmentosa (HP:0000510)1.95066294
72Abnormal respiratory epithelium morphology (HP:0012253)1.93618773
73Abnormal respiratory motile cilium morphology (HP:0005938)1.93618773
74Papilledema (HP:0001085)1.92858094
75Optic nerve coloboma (HP:0000588)1.92138206
76Oligodactyly (HP:0012165)1.91662100
77Decreased circulating renin level (HP:0003351)1.91294954
78Renal hypoplasia (HP:0000089)1.88561002
79Concave nail (HP:0001598)1.88147962
80Broad alveolar ridges (HP:0000187)1.86365291
81Medial flaring of the eyebrow (HP:0010747)1.86299925
82Pachygyria (HP:0001302)1.84934650
83Absent speech (HP:0001344)1.83072749
84Spastic tetraplegia (HP:0002510)1.81619938
85Optic disc pallor (HP:0000543)1.81265298
86X-linked dominant inheritance (HP:0001423)1.80539405
87Methylmalonic aciduria (HP:0012120)1.78918760
88Hypomagnesemia (HP:0002917)1.78499574
89Febrile seizures (HP:0002373)1.78049958
90Bicornuate uterus (HP:0000813)1.77519167
91Abnormal eating behavior (HP:0100738)1.76441687
92Symphalangism affecting the phalanges of the hand (HP:0009773)1.73918581
93Generalized tonic-clonic seizures (HP:0002069)1.73475161
94Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72956556
95Left ventricular hypertrophy (HP:0001712)1.72551763
96True hermaphroditism (HP:0010459)1.71438798
97Tubular atrophy (HP:0000092)1.71297659
98Cupped ear (HP:0000378)1.71219157
99Congenital primary aphakia (HP:0007707)1.70637268
100Abnormal urine output (HP:0012590)1.70124095

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK27.04482394
2WNK35.64360790
3CASK5.50991790
4FRK3.96118467
5WNK43.08730948
6NEK22.77393313
7MARK12.23323193
8DYRK22.22337813
9TLK12.20777198
10PRKD32.00371048
11NTRK21.95797762
12CAMKK11.89653736
13EPHA31.89094199
14TNIK1.85751427
15MAP3K91.75979123
16NTRK31.60581312
17MAP2K71.40538158
18MAPK131.37016343
19IRAK31.35761416
20MAP3K41.20143361
21STK391.18114488
22PAK31.05603876
23STK111.03445527
24SGK4941.01523372
25SGK2231.01523372
26CDC70.99477543
27PRKCG0.96173408
28CAMKK20.95686106
29NTRK10.85879337
30PDK20.85299880
31NEK10.85242834
32MINK10.83514130
33PHKG20.81043490
34PHKG10.81043490
35RPS6KA20.79887498
36CDK50.78333446
37NME10.76463838
38IRAK40.76067039
39PRKCI0.75492519
40GRK10.74117062
41EEF2K0.73322377
42CDK190.72847695
43CCNB10.69400211
44MUSK0.67863793
45MAPKAPK30.63457319
46NUAK10.63238952
47BRSK10.63071879
48PNCK0.62963021
49MAP4K20.61829602
50ADRBK20.59075828
51DMPK0.57581309
52PLK40.54886627
53PKN10.54487415
54CSNK1G20.52020054
55TIE10.50439784
56CAMK10.49576523
57CSNK1G30.48944329
58IRAK10.45321364
59CSNK1E0.45154632
60STK380.43948380
61ABL20.43746234
62TYRO30.43065839
63STK40.42503094
64SGK20.42462513
65DAPK20.42351632
66CAMK1D0.42234205
67PRKACA0.40568162
68MKNK20.40465975
69MAPKAPK50.39818240
70WNK10.39757577
71PINK10.39733081
72MARK30.38720250
73CSNK1G10.38708607
74INSRR0.38529894
75BMPR1B0.37640818
76PLK20.37635498
77OXSR10.35776422
78ERBB20.35708465
79PAK60.34441309
80CSNK1A1L0.34405057
81RPS6KA50.33702468
82ALK0.32098951
83CAMK1G0.31939607
84PRKCA0.31375241
85CSNK1A10.31373134
86FES0.29683175
87PRKCZ0.29543465
88CSNK2A20.28578697
89MAPK120.28473625
90PTK2B0.26924009
91MAP3K110.26903359
92MATK0.26829785
93MAPK40.26782601
94ADRBK10.26233376
95PRKCE0.25860508
96PRKDC0.25531766
97PRKAA10.25448754
98MAPK90.25219296
99PRKAA20.24973901
100MAP2K40.24736951

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.98561880
2Oxidative phosphorylation_Homo sapiens_hsa001903.31290443
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.26040716
4Parkinsons disease_Homo sapiens_hsa050122.77337635
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.76796743
6Cardiac muscle contraction_Homo sapiens_hsa042602.69887085
7Ribosome_Homo sapiens_hsa030102.46789394
8GABAergic synapse_Homo sapiens_hsa047272.26423315
9Morphine addiction_Homo sapiens_hsa050322.26084552
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.22072909
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.06033171
12Phototransduction_Homo sapiens_hsa047441.96181090
13Huntingtons disease_Homo sapiens_hsa050161.92665773
14Dopaminergic synapse_Homo sapiens_hsa047281.91089027
15Alzheimers disease_Homo sapiens_hsa050101.89396569
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.83917036
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72049138
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.70241938
19Taste transduction_Homo sapiens_hsa047421.69543306
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.64313955
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63956592
22Synaptic vesicle cycle_Homo sapiens_hsa047211.54274116
23Circadian entrainment_Homo sapiens_hsa047131.51708456
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49845450
25Glutamatergic synapse_Homo sapiens_hsa047241.45988213
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43117495
27Olfactory transduction_Homo sapiens_hsa047401.41113394
28Protein export_Homo sapiens_hsa030601.39590904
29Regulation of autophagy_Homo sapiens_hsa041401.34741435
30Cholinergic synapse_Homo sapiens_hsa047251.31872576
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31280269
32Axon guidance_Homo sapiens_hsa043601.30976533
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30568893
34ABC transporters_Homo sapiens_hsa020101.28997416
35RNA degradation_Homo sapiens_hsa030181.28059668
36Nitrogen metabolism_Homo sapiens_hsa009101.23430098
37Insulin secretion_Homo sapiens_hsa049111.22539193
38Steroid biosynthesis_Homo sapiens_hsa001001.20153709
39Serotonergic synapse_Homo sapiens_hsa047261.17688420
40Collecting duct acid secretion_Homo sapiens_hsa049661.16186339
41Sulfur relay system_Homo sapiens_hsa041221.15630670
42One carbon pool by folate_Homo sapiens_hsa006701.11423144
43RNA polymerase_Homo sapiens_hsa030201.10869398
44Fatty acid metabolism_Homo sapiens_hsa012121.05896919
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.04928263
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02236456
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01272695
48Basal transcription factors_Homo sapiens_hsa030221.00200412
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99914394
50Sulfur metabolism_Homo sapiens_hsa009200.98108916
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.94619756
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94098843
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92025614
54Peroxisome_Homo sapiens_hsa041460.89708721
55Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85544865
56Oxytocin signaling pathway_Homo sapiens_hsa049210.85532016
57Caffeine metabolism_Homo sapiens_hsa002320.84825621
58Linoleic acid metabolism_Homo sapiens_hsa005910.80827255
59Amphetamine addiction_Homo sapiens_hsa050310.78222905
60Phenylalanine metabolism_Homo sapiens_hsa003600.78062471
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75896170
62Butanoate metabolism_Homo sapiens_hsa006500.73656037
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68365686
64Calcium signaling pathway_Homo sapiens_hsa040200.66595374
65Retinol metabolism_Homo sapiens_hsa008300.62257999
66Fat digestion and absorption_Homo sapiens_hsa049750.58113104
67Cocaine addiction_Homo sapiens_hsa050300.53969542
68Metabolic pathways_Homo sapiens_hsa011000.53180438
69Fanconi anemia pathway_Homo sapiens_hsa034600.51839822
70cAMP signaling pathway_Homo sapiens_hsa040240.51460721
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48992410
72Dilated cardiomyopathy_Homo sapiens_hsa054140.48836185
73Ether lipid metabolism_Homo sapiens_hsa005650.48156583
74Bile secretion_Homo sapiens_hsa049760.47307268
75Basal cell carcinoma_Homo sapiens_hsa052170.46999864
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45825201
77Arginine and proline metabolism_Homo sapiens_hsa003300.43784701
78Chemical carcinogenesis_Homo sapiens_hsa052040.43190280
79Ovarian steroidogenesis_Homo sapiens_hsa049130.42534871
80Base excision repair_Homo sapiens_hsa034100.41936202
81MAPK signaling pathway_Homo sapiens_hsa040100.41429519
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39988848
83PPAR signaling pathway_Homo sapiens_hsa033200.37821505
84Salivary secretion_Homo sapiens_hsa049700.37194871
85Renin secretion_Homo sapiens_hsa049240.36373155
86Selenocompound metabolism_Homo sapiens_hsa004500.35838946
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35621562
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35272900
89Fatty acid degradation_Homo sapiens_hsa000710.35051206
90Gastric acid secretion_Homo sapiens_hsa049710.34565310
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32592630
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32260730
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.32151380
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31218667
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.30072609
96Glycerolipid metabolism_Homo sapiens_hsa005610.29099617
97Ras signaling pathway_Homo sapiens_hsa040140.28948820
98Tryptophan metabolism_Homo sapiens_hsa003800.28788364
99Alcoholism_Homo sapiens_hsa050340.28180020
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28159928

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