PTK2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.18557596
2locomotory exploration behavior (GO:0035641)6.03881844
3synaptic vesicle maturation (GO:0016188)5.78807588
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.72678658
5regulation of B cell receptor signaling pathway (GO:0050855)5.35709296
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.21546764
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.20205889
8* positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.19348621
9antigen processing and presentation of endogenous antigen (GO:0019883)5.10655273
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.06153624
11regulation of neuronal synaptic plasticity (GO:0048168)5.00341222
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.97253004
13* regulation of glutamate receptor signaling pathway (GO:1900449)4.82186153
14synaptic vesicle exocytosis (GO:0016079)4.82092447
15regulation of long-term neuronal synaptic plasticity (GO:0048169)4.79722805
16positive regulation by symbiont of host defense response (GO:0052509)4.77492128
17modulation by symbiont of host defense response (GO:0052031)4.77492128
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.77492128
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.77492128
20positive regulation by organism of defense response of other organism involved in symbiotic interact4.77492128
21modulation by symbiont of host immune response (GO:0052553)4.77492128
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.72948874
23regulation of synapse structural plasticity (GO:0051823)4.70762837
24vocalization behavior (GO:0071625)4.70358000
25glutamate secretion (GO:0014047)4.67872476
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.63577668
27exploration behavior (GO:0035640)4.62247190
28B cell receptor signaling pathway (GO:0050853)4.57731987
29G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.57347348
30detection of other organism (GO:0098543)4.47216086
31detection of bacterium (GO:0016045)4.46280446
32* ionotropic glutamate receptor signaling pathway (GO:0035235)4.45539358
33regulation of gamma-delta T cell activation (GO:0046643)4.45003909
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.36069276
35regulation of synaptic vesicle exocytosis (GO:2000300)4.34068190
36neurotransmitter-gated ion channel clustering (GO:0072578)4.25103615
37macrophage activation involved in immune response (GO:0002281)4.23384006
38long-term memory (GO:0007616)4.21350045
39protein localization to synapse (GO:0035418)4.14098782
40regulation of synaptic vesicle transport (GO:1902803)4.10387952
41negative thymic T cell selection (GO:0045060)4.07288280
42synaptic transmission, glutamatergic (GO:0035249)4.05367660
43response to peptidoglycan (GO:0032494)4.05259372
44neutrophil activation involved in immune response (GO:0002283)4.04698890
45regulation of dendritic spine morphogenesis (GO:0061001)4.04663903
46* regulation of synaptic plasticity (GO:0048167)4.01925395
47positive thymic T cell selection (GO:0045059)4.00675197
48immunoglobulin mediated immune response (GO:0016064)4.00256202
49negative regulation of erythrocyte differentiation (GO:0045647)3.99643970
50negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.95208172
51negative regulation of cell killing (GO:0031342)3.95208172
52positive regulation of B cell differentiation (GO:0045579)3.94560616
53regulation of gamma-delta T cell differentiation (GO:0045586)3.92142862
54negative T cell selection (GO:0043383)3.89831672
55leukocyte aggregation (GO:0070486)3.89197970
56* regulation of excitatory postsynaptic membrane potential (GO:0060079)3.86466653
57negative regulation of lymphocyte mediated immunity (GO:0002707)3.84145416
58T cell migration (GO:0072678)3.81809150
59* glutamate receptor signaling pathway (GO:0007215)3.81498525
60neuronal action potential propagation (GO:0019227)3.79182166
61response to muramyl dipeptide (GO:0032495)3.78011926
62negative regulation of T cell mediated immunity (GO:0002710)3.77218835
63response to interleukin-15 (GO:0070672)3.75003298
64membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.70042827
65* regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.69821709
66neuron-neuron synaptic transmission (GO:0007270)3.68164476
67neurotransmitter secretion (GO:0007269)3.68147492
68regulation of ARF protein signal transduction (GO:0032012)3.68044315
69cellular extravasation (GO:0045123)3.64986364
70positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.63886829
71regulation of B cell differentiation (GO:0045577)3.61396561
72cellular response to type I interferon (GO:0071357)3.60850384
73type I interferon signaling pathway (GO:0060337)3.60850384
74interferon-gamma-mediated signaling pathway (GO:0060333)3.60522675
75response to type I interferon (GO:0034340)3.59360198
76negative regulation of interleukin-12 production (GO:0032695)3.59166802
77negative regulation of leukocyte mediated immunity (GO:0002704)3.56246336
78detection of external biotic stimulus (GO:0098581)3.56091152
79germinal center formation (GO:0002467)3.55508170
80positive regulation of synapse maturation (GO:0090129)3.51728703
81* regulation of postsynaptic membrane potential (GO:0060078)3.49146822
82thymic T cell selection (GO:0045061)3.48864218
83cellular potassium ion homeostasis (GO:0030007)3.48559667
84cellular response to interleukin-15 (GO:0071350)3.47208326
85dendritic spine morphogenesis (GO:0060997)3.45916099
86response to host immune response (GO:0052572)3.45136749
87response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.45136749
88regulation of interferon-beta biosynthetic process (GO:0045357)3.43058444
89positive regulation of fibroblast migration (GO:0010763)3.40782528
90neuromuscular process controlling balance (GO:0050885)3.40446266
91myeloid cell activation involved in immune response (GO:0002275)3.39678450
92* long-term synaptic potentiation (GO:0060291)3.38355535
93T cell selection (GO:0045058)3.38267010
94positive regulation of neurotransmitter secretion (GO:0001956)3.37434774
95positive regulation of dendritic spine morphogenesis (GO:0061003)3.37219881
96positive T cell selection (GO:0043368)3.36092961
97sodium ion export (GO:0071436)3.35343839
98behavioral defense response (GO:0002209)3.35013493
99behavioral fear response (GO:0001662)3.35013493
100positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.34458167
101regulation of Rap GTPase activity (GO:0032317)3.34049272
102regulation of dendritic spine development (GO:0060998)3.33469426
103* positive regulation of membrane potential (GO:0045838)3.32759979
104activation of protein kinase A activity (GO:0034199)3.22116455
105response to histamine (GO:0034776)3.22110572
106regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.21207804
107dendritic spine organization (GO:0097061)3.20412698
108defense response to protozoan (GO:0042832)3.20142702
109response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.19756830
110response to host (GO:0075136)3.19756830
111response to host defenses (GO:0052200)3.19756830
112regulation of dendritic cell antigen processing and presentation (GO:0002604)3.16315180
113regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.15638570
114regulation of mast cell degranulation (GO:0043304)3.15563246
115proline transport (GO:0015824)3.14328513
116microglial cell activation (GO:0001774)3.13569845
117regulation of alpha-beta T cell proliferation (GO:0046640)3.13188406
118positive regulation of neurotransmitter transport (GO:0051590)3.13050889
119regulation of female receptivity (GO:0045924)3.11966337
120neutrophil activation (GO:0042119)3.11517828
121synaptic vesicle endocytosis (GO:0048488)3.10209189
122respiratory burst (GO:0045730)3.09776427
123detection of biotic stimulus (GO:0009595)3.09514095
124B cell mediated immunity (GO:0019724)3.09447779
125positive regulation of dendritic spine development (GO:0060999)3.07278336
126positive regulation of synaptic transmission, GABAergic (GO:0032230)3.07207101
127response to amphetamine (GO:0001975)3.06809466
128chemosensory behavior (GO:0007635)3.06301135
129prepulse inhibition (GO:0060134)3.05886992
130L-amino acid import (GO:0043092)3.05535345
131negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.05146315
132positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.04534338
133detection of molecule of bacterial origin (GO:0032490)3.03127252
134B cell homeostasis (GO:0001782)3.02498556
135regulation of vesicle fusion (GO:0031338)3.01587357
136regulation of myeloid leukocyte mediated immunity (GO:0002886)3.00650359
137long term synaptic depression (GO:0060292)3.00567308
138negative regulation of amino acid transport (GO:0051956)3.00512862
139response to protozoan (GO:0001562)2.99872016
140mast cell activation (GO:0045576)2.99333309
141positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.99166788
142fear response (GO:0042596)2.98160982
143regulation of leukocyte degranulation (GO:0043300)2.96469895
144gamma-aminobutyric acid signaling pathway (GO:0007214)2.93472758
145* regulation of synaptic transmission, glutamatergic (GO:0051966)2.93135465
146positive regulation of Rap GTPase activity (GO:0032854)2.92866998
147learning (GO:0007612)2.92602319
148macrophage activation (GO:0042116)2.92413843
149leukocyte degranulation (GO:0043299)2.91770922
150vesicle transport along microtubule (GO:0047496)2.90391264
151* regulation of synaptic transmission (GO:0050804)2.90287828
152regulation of glutamate secretion (GO:0014048)2.90243539
153* membrane depolarization (GO:0051899)2.89843301
154antigen receptor-mediated signaling pathway (GO:0050851)2.89563957
155granulocyte activation (GO:0036230)2.89419098
156regulation of neurotransmitter secretion (GO:0046928)2.88938099
157regulation of antigen processing and presentation (GO:0002577)2.87954803
158nerve growth factor signaling pathway (GO:0038180)2.87319912
159regulation of mast cell activation involved in immune response (GO:0033006)2.86641126
160mast cell degranulation (GO:0043303)2.85883043
161mast cell activation involved in immune response (GO:0002279)2.85883043
162negative regulation of synaptic transmission, GABAergic (GO:0032229)2.84478549
163positive regulation of granulocyte differentiation (GO:0030854)2.83785617
164* positive regulation of synaptic transmission (GO:0050806)2.82831921
165positive regulation of vesicle fusion (GO:0031340)2.82807673
166layer formation in cerebral cortex (GO:0021819)2.82748854
167tolerance induction (GO:0002507)2.82560734
168positive regulation of mast cell activation (GO:0033005)2.81360015
169regulation of T cell tolerance induction (GO:0002664)2.80816664
170adenosine receptor signaling pathway (GO:0001973)2.80791476
171serotonin metabolic process (GO:0042428)2.80478617
172transmission of nerve impulse (GO:0019226)2.80028841
173synaptic transmission, dopaminergic (GO:0001963)2.79754255
174negative regulation of toll-like receptor signaling pathway (GO:0034122)2.78723546
175regulation of regulated secretory pathway (GO:1903305)2.78135090
176visual learning (GO:0008542)2.77974936
177NIK/NF-kappaB signaling (GO:0038061)2.77895148
178regulation of tolerance induction (GO:0002643)2.77821502
179regulation of ARF GTPase activity (GO:0032312)2.76800409
180neurotransmitter transport (GO:0006836)2.76508307
181regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.75755603
182antigen processing and presentation via MHC class Ib (GO:0002475)2.75642197
183neuron cell-cell adhesion (GO:0007158)2.75060263
184regulation of neurotransmitter levels (GO:0001505)2.74935965
185lipopolysaccharide-mediated signaling pathway (GO:0031663)2.74894142
186negative regulation of innate immune response (GO:0045824)2.74185893
187CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.74115422
188dopamine receptor signaling pathway (GO:0007212)2.73756155
189cellular sodium ion homeostasis (GO:0006883)2.72993062
190gamma-aminobutyric acid transport (GO:0015812)2.72384559
191* positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.72047047
192positive regulation of type 2 immune response (GO:0002830)2.71678627
193cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.70255477
194positive regulation of interferon-alpha production (GO:0032727)2.69245412
195regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.68820357

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.24139571
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.50959618
3RARB_27405468_Chip-Seq_BRAIN_Mouse3.47286287
4* VDR_21846776_ChIP-Seq_THP-1_Human3.19185617
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.93879416
6IKZF1_21737484_ChIP-ChIP_HCT116_Human2.90552506
7* VDR_24763502_ChIP-Seq_THP-1_Human2.76537319
8DROSHA_22980978_ChIP-Seq_HELA_Human2.71951096
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.71591525
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70981215
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.63412702
12SCL_19346495_ChIP-Seq_HPC-7_Human2.62517049
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61000403
14GBX2_23144817_ChIP-Seq_PC3_Human2.59594220
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59329815
16MAF_26560356_Chip-Seq_TH1_Human2.55552250
17* REST_21632747_ChIP-Seq_MESCs_Mouse2.51338922
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.44855985
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.43687790
20* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40678210
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39463720
22MYB_26560356_Chip-Seq_TH2_Human2.38685741
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.36958312
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.34329353
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30332383
26MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29471638
27RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29084442
28EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29084442
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.28032563
30JARID2_20075857_ChIP-Seq_MESCs_Mouse2.25516227
31UTX_26944678_Chip-Seq_JUKART_Human2.19742508
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.18535775
33* SPI1_23547873_ChIP-Seq_NB4_Human2.17770975
34STAT4_19710469_ChIP-ChIP_TH1__Mouse2.17617259
35* REST_18959480_ChIP-ChIP_MESCs_Mouse2.12089188
36RUNX1_22412390_ChIP-Seq_EML_Mouse2.11425991
37MYB_26560356_Chip-Seq_TH1_Human2.09098445
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.07287949
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.03886486
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.02337455
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.00631148
42SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00610889
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.98156047
44MAF_26560356_Chip-Seq_TH2_Human1.91519870
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.84844868
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.84592328
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74603687
48GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.74408226
49* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.73021667
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.68773978
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.67210216
52EZH2_27304074_Chip-Seq_ESCs_Mouse1.64486097
53GATA1_22025678_ChIP-Seq_K562_Human1.63854992
54GATA3_27048872_Chip-Seq_THYMUS_Human1.62569924
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61125173
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60359565
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.60357601
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.56888799
59* VDR_24787735_ChIP-Seq_THP-1_Human1.50682964
60* GATA1_19941826_ChIP-Seq_K562_Human1.49876361
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45394951
62AR_21572438_ChIP-Seq_LNCaP_Human1.44190104
63EED_16625203_ChIP-ChIP_MESCs_Mouse1.41916783
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.40906096
65* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39213781
66* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39178679
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37442516
68KDM2B_26808549_Chip-Seq_K562_Human1.35134073
69GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33645646
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32934168
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.32662825
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31463472
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30198070
74* SPI1_23127762_ChIP-Seq_K562_Human1.29750288
75* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27511591
76KDM2B_26808549_Chip-Seq_DND41_Human1.27384974
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27379438
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26928611
79SMAD4_21799915_ChIP-Seq_A2780_Human1.26735082
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.26475537
81RUNX_20019798_ChIP-Seq_JUKART_Human1.25108411
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24560777
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23801348
84PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23189881
85IRF8_21731497_ChIP-ChIP_J774_Mouse1.20675335
86* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19353108
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19281788
88* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18189264
89* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17568480
90* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16081897
91* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14665166
92* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13628837
93LXR_22292898_ChIP-Seq_THP-1_Human1.12718588
94PU_27001747_Chip-Seq_BMDM_Mouse1.12710873
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12599932
96RXR_22108803_ChIP-Seq_LS180_Human1.12459532
97FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.12400886
98BCOR_27268052_Chip-Seq_Bcells_Human1.12191972
99ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11539317
100CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10981066
101BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10589832
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08990313
103BCL6_27268052_Chip-Seq_Bcells_Human1.08416745
104GATA3_26560356_Chip-Seq_TH2_Human1.08102800
105* GATA2_19941826_ChIP-Seq_K562_Human1.07522770
106CIITA_25753668_ChIP-Seq_RAJI_Human1.06951508
107AR_19668381_ChIP-Seq_PC3_Human1.06526093
108CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05622130
109VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05607099
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05168102
111SOX2_21211035_ChIP-Seq_LN229_Gbm1.04347613
112RING1B_27294783_Chip-Seq_ESCs_Mouse1.03536980
113* AR_25329375_ChIP-Seq_VCAP_Human1.03500824
114E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03048242
115CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02880096
116KDM2B_26808549_Chip-Seq_JURKAT_Human1.02596698
117* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01852589
118PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01791867
119ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01721250
120TCF7_22412390_ChIP-Seq_EML_Mouse1.01278546
121SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99966995
122IRF8_27001747_Chip-Seq_BMDM_Mouse0.99144867
123P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99008239
124* NCOR1_26117541_ChIP-Seq_K562_Human0.98839697
125* PRDM14_20953172_ChIP-Seq_ESCs_Human0.98806276
126ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97625462
127ELF1_20517297_ChIP-Seq_JURKAT_Human0.97343414
128KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96790595
129* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95461496
130TP53_16413492_ChIP-PET_HCT116_Human0.95234187
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94228603
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92897710
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92535897
134CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92275826
135SA1_27219007_Chip-Seq_ERYTHROID_Human0.92225205
136P68_20966046_ChIP-Seq_HELA_Human0.92077747
137SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91548247
138SMAD3_21741376_ChIP-Seq_HESCs_Human0.90542830
139SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90316862
140CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89704185
141* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89325322
142NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89273898
143* GATA1_19941827_ChIP-Seq_MEL_Mouse0.88993492
144P300_19829295_ChIP-Seq_ESCs_Human0.88965365
145NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88730178
146* STAT3_23295773_ChIP-Seq_U87_Human0.88462945
147* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87806129
148* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87762262
149KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87274497
150STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.87224988
151SMAD3_21741376_ChIP-Seq_EPCs_Human0.87137308
152ARNT_22903824_ChIP-Seq_MCF-7_Human0.86971091
153MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86258611
154PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85303256
155GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85205664
156IRF8_22096565_ChIP-ChIP_GC-B_Human0.85137650
157* GATA2_21666600_ChIP-Seq_HMVEC_Human0.84491343
158MYC_22102868_ChIP-Seq_BL_Human0.83842265
159AHR_22903824_ChIP-Seq_MCF-7_Human0.83411103
160SMC4_20622854_ChIP-Seq_HELA_Human0.82184220
161TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80454405
162TCF4_23295773_ChIP-Seq_U87_Human0.80289720
163GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79411426

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity8.18741811
2MP0003880_abnormal_central_pattern4.82812528
3MP0002822_catalepsy4.26393853
4MP0003635_abnormal_synaptic_transmissio4.20269647
5MP0009745_abnormal_behavioral_response3.47956640
6MP0002063_abnormal_learning/memory/cond3.45176615
7MP0003724_increased_susceptibility_to3.24880406
8MP0002064_seizures3.06966094
9MP0004270_analgesia3.05383575
10MP0002572_abnormal_emotion/affect_behav2.66290715
11MP0001501_abnormal_sleep_pattern2.60796869
12MP0009785_altered_susceptibility_to2.48921617
13MP0001968_abnormal_touch/_nociception2.39092416
14MP0004510_myositis2.35354844
15MP0009046_muscle_twitch2.22531354
16MP0003075_altered_response_to2.16364949
17MP0002272_abnormal_nervous_system2.15238549
18MP0001486_abnormal_startle_reflex2.11762845
19MP0003329_amyloid_beta_deposits1.93582492
20MP0002736_abnormal_nociception_after1.93502100
21MP0004947_skin_inflammation1.91312732
22MP0010155_abnormal_intestine_physiology1.87454807
23MP0002735_abnormal_chemical_nociception1.87275832
24MP0008260_abnormal_autophagy1.83191401
25MP0005423_abnormal_somatic_nervous1.82770480
26MP0002405_respiratory_system_inflammati1.81255573
27MP0002909_abnormal_adrenal_gland1.81102235
28MP0008569_lethality_at_weaning1.79570585
29MP0002396_abnormal_hematopoietic_system1.78062488
30MP0001440_abnormal_grooming_behavior1.74209441
31MP0009780_abnormal_chondrocyte_physiolo1.72572674
32MP0000689_abnormal_spleen_morphology1.71911641
33MP0002722_abnormal_immune_system1.68629757
34MP0003879_abnormal_hair_cell1.68181727
35MP0003303_peritoneal_inflammation1.66768620
36MP0000569_abnormal_digit_pigmentation1.66122453
37* MP0001845_abnormal_inflammatory_respons1.64611176
38MP0009333_abnormal_splenocyte_physiolog1.64046142
39MP0002429_abnormal_blood_cell1.63403033
40MP0004811_abnormal_neuron_physiology1.63056351
41MP0001533_abnormal_skeleton_physiology1.62329167
42MP0002734_abnormal_mechanical_nocicepti1.62028926
43MP0003787_abnormal_imprinting1.61865850
44MP0003191_abnormal_cellular_cholesterol1.61774071
45MP0003866_abnormal_defecation1.60194280
46MP0009278_abnormal_bone_marrow1.58180892
47MP0002166_altered_tumor_susceptibility1.54635060
48MP0000703_abnormal_thymus_morphology1.54606755
49MP0003172_abnormal_lysosome_physiology1.50442117
50MP0000604_amyloidosis1.48750218
51MP0004858_abnormal_nervous_system1.47156935
52MP0005451_abnormal_body_composition1.46682871
53MP0001970_abnormal_pain_threshold1.46415345
54MP0010234_abnormal_vibrissa_follicle1.45317862
55MP0003633_abnormal_nervous_system1.42791468
56MP0008874_decreased_physiological_sensi1.38628337
57MP0005646_abnormal_pituitary_gland1.38097043
58MP0002733_abnormal_thermal_nociception1.36798132
59MP0004924_abnormal_behavior1.35164928
60MP0005386_behavior/neurological_phenoty1.35164928
61MP0002067_abnormal_sensory_capabilities1.33843859
62MP0001545_abnormal_hematopoietic_system1.32361461
63MP0005397_hematopoietic_system_phenotyp1.32361461
64MP0005310_abnormal_salivary_gland1.30937038
65MP0000465_gastrointestinal_hemorrhage1.29584022
66MP0008961_abnormal_basal_metabolism1.28761644
67MP0002557_abnormal_social/conspecific_i1.26394454
68MP0004381_abnormal_hair_follicle1.24576158
69MP0001851_eye_inflammation1.23385284
70MP0008469_abnormal_protein_level1.23191162
71MP0005166_decreased_susceptibility_to1.16247795
72MP0001835_abnormal_antigen_presentation1.13858642
73MP0003183_abnormal_peptide_metabolism1.10524047
74MP0008872_abnormal_physiological_respon1.10021606
75MP0002066_abnormal_motor_capabilities/c1.09813585
76MP0002998_abnormal_bone_remodeling1.08978738
77MP0005167_abnormal_blood-brain_barrier1.08651871
78MP0001853_heart_inflammation1.08530075
79MP0003631_nervous_system_phenotype1.08465128
80MP0003656_abnormal_erythrocyte_physiolo1.07192135
81MP0002006_tumorigenesis1.06185091
82MP0005535_abnormal_body_temperature1.05350152
83MP0000858_altered_metastatic_potential1.04377872
84MP0002138_abnormal_hepatobiliary_system1.03576320
85MP0003690_abnormal_glial_cell1.03029281
86MP0001790_abnormal_immune_system1.01019041
87MP0005387_immune_system_phenotype1.01019041
88MP0003828_pulmonary_edema1.00209716
89MP0001905_abnormal_dopamine_level1.00168230
90MP0009764_decreased_sensitivity_to0.99789985
91MP0001502_abnormal_circadian_rhythm0.99755750
92MP0004885_abnormal_endolymph0.99597127
93MP0005671_abnormal_response_to0.97601941
94MP0004808_abnormal_hematopoietic_stem0.97052396
95MP0000955_abnormal_spinal_cord0.94417857
96MP0001800_abnormal_humoral_immune0.94280906
97MP0002184_abnormal_innervation0.94072977
98MP0002132_abnormal_respiratory_system0.93175329
99MP0005000_abnormal_immune_tolerance0.91240203
100MP0002882_abnormal_neuron_morphology0.89058702
101MP0002009_preneoplasia0.88034169
102MP0001984_abnormal_olfaction0.86668809
103MP0005464_abnormal_platelet_physiology0.86575620
104MP0000685_abnormal_immune_system0.85469565
105MP0002069_abnormal_eating/drinking_beha0.85220044
106MP0002723_abnormal_immune_serum0.82185727
107MP0003300_gastrointestinal_ulcer0.80674636
108MP0000778_abnormal_nervous_system0.80460608
109MP0004883_abnormal_blood_vessel0.79740839
110MP0005075_abnormal_melanosome_morpholog0.78979312
111MP0001348_abnormal_lacrimal_gland0.76790741
112* MP0002420_abnormal_adaptive_immunity0.76787191
113* MP0001819_abnormal_immune_cell0.76159110
114MP0005058_abnormal_lysosome_morphology0.75960886
115* MP0002452_abnormal_antigen_presenting0.75473744
116MP0001986_abnormal_taste_sensitivity0.75196599
117MP0000015_abnormal_ear_pigmentation0.73186828
118MP0003436_decreased_susceptibility_to0.71922047
119MP0001663_abnormal_digestive_system0.70637688
120MP0005409_darkened_coat_color0.70500485
121MP0009763_increased_sensitivity_to0.70204326
122MP0003045_fibrosis0.69523977
123MP0003091_abnormal_cell_migration0.69191632
124MP0001529_abnormal_vocalization0.68940442
125MP0002933_joint_inflammation0.66585911
126MP0004130_abnormal_muscle_cell0.65419236
127MP0000490_abnormal_crypts_of0.64929154
128MP0000920_abnormal_myelination0.64522431
129* MP0002419_abnormal_innate_immunity0.64211637
130MP0001873_stomach_inflammation0.63828347
131* MP0001765_abnormal_ion_homeostasis0.63823637
132MP0002152_abnormal_brain_morphology0.63635747
133MP0002090_abnormal_vision0.63560540
134MP0002398_abnormal_bone_marrow0.63409985
135MP0003448_altered_tumor_morphology0.62488929
136MP0001177_atelectasis0.61837259
137MP0002876_abnormal_thyroid_physiology0.61379302
138MP0005645_abnormal_hypothalamus_physiol0.60905186
139MP0002148_abnormal_hypersensitivity_rea0.59297356
140MP0009840_abnormal_foam_cell0.58118546
141MP0000716_abnormal_immune_system0.58060860
142MP0002229_neurodegeneration0.57001029
143MP0009765_abnormal_xenobiotic_induced0.56573794
144MP0008004_abnormal_stomach_pH0.55791623
145MP0005025_abnormal_response_to0.55360780
146MP0002019_abnormal_tumor_incidence0.54971723
147MP0004484_altered_response_of0.54080250
148MP0000249_abnormal_blood_vessel0.53887289
149MP0003763_abnormal_thymus_physiology0.53536623
150MP0005076_abnormal_cell_differentiation0.53504251
151MP0006082_CNS_inflammation0.52949419
152MP0005174_abnormal_tail_pigmentation0.52938218
153MP0002693_abnormal_pancreas_physiology0.52374553
154MP0003632_abnormal_nervous_system0.51931067
155MP0005164_abnormal_response_to0.50738691
156MP0005390_skeleton_phenotype0.50031418
157MP0000343_altered_response_to0.48385911

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.79935702
2Myokymia (HP:0002411)7.40244072
3Focal seizures (HP:0007359)5.56940789
4Eczematoid dermatitis (HP:0000976)5.53745381
5Recurrent bacterial skin infections (HP:0005406)4.92274652
6Visual hallucinations (HP:0002367)4.88800440
7Recurrent abscess formation (HP:0002722)4.81988646
8Myositis (HP:0100614)4.32002678
9Abnormality of macrophages (HP:0004311)4.29942080
10Meningitis (HP:0001287)4.23858319
11Epileptic encephalopathy (HP:0200134)4.19080248
12Abnormal delayed hypersensitivity skin test (HP:0002963)4.14326031
13Recurrent fungal infections (HP:0002841)4.00618603
14Febrile seizures (HP:0002373)3.93838873
15Orchitis (HP:0100796)3.92457796
16Retrobulbar optic neuritis (HP:0100654)3.87385158
17Optic neuritis (HP:0100653)3.87385158
18Atonic seizures (HP:0010819)3.84027454
19Absence seizures (HP:0002121)3.74414148
20Vasculitis (HP:0002633)3.72296768
21Elevated erythrocyte sedimentation rate (HP:0003565)3.68571008
22Recurrent cutaneous fungal infections (HP:0011370)3.67278965
23Chronic mucocutaneous candidiasis (HP:0002728)3.67278965
24Impaired vibration sensation in the lower limbs (HP:0002166)3.63425765
25Recurrent viral infections (HP:0004429)3.62231952
26Cellulitis (HP:0100658)3.61332517
27Gastrointestinal stroma tumor (HP:0100723)3.60887792
28Dialeptic seizures (HP:0011146)3.58894080
29Recurrent gram-negative bacterial infections (HP:0005420)3.56547501
30Abnormality of the lower motor neuron (HP:0002366)3.54882215
31Recurrent skin infections (HP:0001581)3.54153233
32Annular pancreas (HP:0001734)3.51847705
33Panhypogammaglobulinemia (HP:0003139)3.51170985
34Chronic obstructive pulmonary disease (HP:0006510)3.47889348
35Obstructive lung disease (HP:0006536)3.47889348
36Papilledema (HP:0001085)3.47537773
37Stomatitis (HP:0010280)3.47150832
38Supranuclear gaze palsy (HP:0000605)3.46689624
39Action tremor (HP:0002345)3.40423080
40Encephalitis (HP:0002383)3.38765431
41Generalized tonic-clonic seizures (HP:0002069)3.38042091
42Colitis (HP:0002583)3.37194974
43Gastrointestinal infarctions (HP:0005244)3.32273427
44Depression (HP:0000716)3.27425449
45Inflammation of the large intestine (HP:0002037)3.26157080
46Poor eye contact (HP:0000817)3.24624504
47Gastrointestinal inflammation (HP:0004386)3.20558809
48Progressive cerebellar ataxia (HP:0002073)3.18875621
49Postural instability (HP:0002172)3.13674189
50Dysmetria (HP:0001310)3.11526202
51Abnormal social behavior (HP:0012433)3.06068936
52Impaired social interactions (HP:0000735)3.06068936
53Stereotypic behavior (HP:0000733)3.02765456
54Urticaria (HP:0001025)3.01205793
55Spontaneous hematomas (HP:0007420)2.94707916
56Lymphopenia (HP:0001888)2.91196507
57Gaze-evoked nystagmus (HP:0000640)2.90756110
58Anxiety (HP:0000739)2.90569853
59Urinary bladder sphincter dysfunction (HP:0002839)2.89082973
60Pulmonary infiltrates (HP:0002113)2.88744188
61Amblyopia (HP:0000646)2.88149595
62Keratoconjunctivitis sicca (HP:0001097)2.87018761
63Gingivitis (HP:0000230)2.86449019
64Broad-based gait (HP:0002136)2.83331555
65Prolonged bleeding time (HP:0003010)2.83150223
66Impaired smooth pursuit (HP:0007772)2.79461367
67T lymphocytopenia (HP:0005403)2.78606099
68Abnormality of T cells (HP:0002843)2.76782680
69Truncal ataxia (HP:0002078)2.75598925
70Ankle clonus (HP:0011448)2.74202912
71Recurrent sinusitis (HP:0011108)2.74006067
72Abnormality of cells of the lymphoid lineage (HP:0012140)2.73989663
73Osteomyelitis (HP:0002754)2.73474480
74Chest pain (HP:0100749)2.71011725
75Abnormality of T cell number (HP:0011839)2.70925415
76Pustule (HP:0200039)2.70105555
77Dysdiadochokinesis (HP:0002075)2.69907692
78Recurrent bronchitis (HP:0002837)2.68672841
79Hemiplegia (HP:0002301)2.67357138
80Mutism (HP:0002300)2.67285624
81Hyperventilation (HP:0002883)2.67140411
82Diplopia (HP:0000651)2.67073309
83Abnormality of binocular vision (HP:0011514)2.67073309
84Torticollis (HP:0000473)2.66883780
85Abnormality of T cell physiology (HP:0011840)2.66403911
86Abnormal eating behavior (HP:0100738)2.65034282
87Dysmetric saccades (HP:0000641)2.64616466
88Focal dystonia (HP:0004373)2.64285063
89Keratoconjunctivitis (HP:0001096)2.61204051
90Urinary urgency (HP:0000012)2.61176508
91IgM deficiency (HP:0002850)2.57988524
92Hemoptysis (HP:0002105)2.56702960
93Bradykinesia (HP:0002067)2.55616059
94Pointed chin (HP:0000307)2.54445407
95Slow saccadic eye movements (HP:0000514)2.50642241
96Impaired vibratory sensation (HP:0002495)2.46562585
97Granulocytopenia (HP:0001913)2.45202640
98Cerebral inclusion bodies (HP:0100314)2.44962501
99Epistaxis (HP:0000421)2.42862629
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.41514019
101Autoimmune hemolytic anemia (HP:0001890)2.39990090
102Progressive inability to walk (HP:0002505)2.38828616
103Hypochromic anemia (HP:0001931)2.38783999
104Increased IgM level (HP:0003496)2.38246265
105Abnormality of ocular smooth pursuit (HP:0000617)2.37410818
106Restrictive lung disease (HP:0002091)2.34077519
107Resting tremor (HP:0002322)2.33711681
108Viral hepatitis (HP:0006562)2.33047811
109Leukocytosis (HP:0001974)2.32608150
110Sepsis (HP:0100806)2.32376346
111Ankyloglossia (HP:0010296)2.31635333
112Abnormality of the periventricular white matter (HP:0002518)2.28001234
113Gingival bleeding (HP:0000225)2.27705161
114Intention tremor (HP:0002080)2.27582812
115Arterial thrombosis (HP:0004420)2.25934464
116Pulmonary embolism (HP:0002204)2.24598778
117Apathy (HP:0000741)2.24114009
118Emphysema (HP:0002097)2.23064576
119Craniofacial dystonia (HP:0012179)2.21987723
120Petechiae (HP:0000967)2.19668636
121Lower limb amyotrophy (HP:0007210)2.19253990
122Hypergammaglobulinemia (HP:0010702)2.19045507
123Hypochromic microcytic anemia (HP:0004840)2.18806113
124Abnormality of the fingertips (HP:0001211)2.18543264
125Lower limb asymmetry (HP:0100559)2.16084083
126Deep palmar crease (HP:0006191)2.15477675
127Neurofibrillary tangles (HP:0002185)2.15340904
128Chronic diarrhea (HP:0002028)2.14713578
129Scanning speech (HP:0002168)2.14643927
130Spastic gait (HP:0002064)2.14221271
131Episodic fever (HP:0001954)2.13943416
132Bundle branch block (HP:0011710)2.13740448
133Skin rash (HP:0000988)2.13633469
134Status epilepticus (HP:0002133)2.13559711
135Autoimmune thrombocytopenia (HP:0001973)2.13252530
136Genetic anticipation (HP:0003743)2.10182690
137Drooling (HP:0002307)2.08878310
138Excessive salivation (HP:0003781)2.08878310
139Abnormality of oral frenula (HP:0000190)2.08802425
140Skin ulcer (HP:0200042)2.07255224
141Global brain atrophy (HP:0002283)2.06792984
142Abnormality of the pleura (HP:0002103)2.04649412
143Spinal canal stenosis (HP:0003416)2.04177405
144Neuronal loss in central nervous system (HP:0002529)2.03335902
145Chronic otitis media (HP:0000389)2.02675766
146Diminished motivation (HP:0000745)2.01931757
147Recurrent lower respiratory tract infections (HP:0002783)1.99347529
148Inappropriate behavior (HP:0000719)1.98995240
149Recurrent pneumonia (HP:0006532)1.98980084
150Increased IgE level (HP:0003212)1.97235235
151Ocular albinism (HP:0001107)1.96835054
152Premature loss of primary teeth (HP:0006323)1.96167583
153Rapidly progressive (HP:0003678)1.95929239
154IgA deficiency (HP:0002720)1.95442264
155Abnormality of saccadic eye movements (HP:0000570)1.93520760
156Epileptiform EEG discharges (HP:0011182)1.92958193
157Gangrene (HP:0100758)1.92594353
158Increased cerebral lipofuscin (HP:0011813)1.91607111
159Ventricular fibrillation (HP:0001663)1.91451381
160Arthralgia (HP:0002829)1.88787731
161Amyloidosis (HP:0011034)1.87696923
162IgG deficiency (HP:0004315)1.87221406
163Eosinophilia (HP:0001880)1.86250378
164Psychosis (HP:0000709)1.85223681
165Obstructive sleep apnea (HP:0002870)1.85111377
166Anorexia (HP:0002039)1.84473919
167Polygenic inheritance (HP:0010982)1.84431896
168Memory impairment (HP:0002354)1.84332055
169Decreased circulating renin level (HP:0003351)1.84012225
170Microcytic anemia (HP:0001935)1.83995304
171Generalized myoclonic seizures (HP:0002123)1.83785275
172Iris hypopigmentation (HP:0007730)1.83646818
173Incomplete penetrance (HP:0003829)1.83436925
174Rigidity (HP:0002063)1.83310688
175Fatigue (HP:0012378)1.83222113
176Dementia (HP:0000726)1.76009118
177Mediastinal lymphadenopathy (HP:0100721)1.75672942
178Verrucae (HP:0200043)1.73736163
179Papilloma (HP:0012740)1.73736163
180Inability to walk (HP:0002540)1.72587337
181Agammaglobulinemia (HP:0004432)1.71398072
182Hemiparesis (HP:0001269)1.71127692
183Dyskinesia (HP:0100660)1.70373301
184Deeply set eye (HP:0000490)1.69809642
185Spastic tetraparesis (HP:0001285)1.69505790
186EEG with generalized epileptiform discharges (HP:0011198)1.67665054
187Insomnia (HP:0100785)1.67327868

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.76859202
2NTRK34.67080199
3MAP3K93.98187722
4RIPK43.77761632
5MAP3K133.37445656
6KSR22.98808429
7DAPK22.74645680
8ERN12.48770186
9BLK2.44969367
10TYK22.41691715
11FES2.40275748
12ARAF2.21321347
13IRAK42.17359155
14PRKD32.11927510
15MINK12.07143842
16DAPK11.97775490
17CAMKK11.93943062
18MAP2K31.92318204
19PRPF4B1.90205293
20KSR11.87429076
21SIK21.82114900
22BTK1.81332834
23CSK1.74562769
24PAK61.69898553
25MAP3K41.67203712
26MAP3K121.63041682
27RAF11.60144409
28ZAP701.56752792
29MAP3K21.42816343
30CDK51.39874054
31MAP4K11.35937658
32MAP2K71.35001037
33TAOK31.33097045
34CSF1R1.28440553
35MAP3K111.26053498
36BMPR21.25347791
37PRKCH1.24402398
38NTRK21.20940582
39TAOK11.19098459
40MAP2K41.18064639
41PDK11.16769710
42ITK1.16432394
43* LYN1.15316577
44SMG11.13502252
45GRK61.11345804
46CAMK11.09623358
47NTRK11.08376971
48STK381.07777408
49LCK1.05687709
50MAP3K11.03813656
51TNIK1.03367209
52MAP3K71.02350715
53TEC0.98663956
54IKBKB0.94735381
55PRKCG0.92832172
56EPHB10.92161990
57PLK20.91900766
58PDPK10.90406259
59SGK30.89127955
60GRK50.87444477
61FGFR30.87386916
62TYRO30.87386241
63SIK30.86688845
64CDK190.86408238
65MAP3K30.86226380
66ALK0.84851947
67CDK120.83321458
68FGFR40.81887032
69TNK20.80413013
70FGR0.78706029
71* SYK0.78040848
72JAK10.77349418
73MATK0.77176030
74MARK30.74181108
75SGK20.74022413
76HIPK20.72298537
77STK110.71048575
78SGK10.70442666
79RET0.70138549
80CAMK2A0.69032152
81CAMK2B0.68867219
82CAMKK20.67860178
83MARK20.63774786
84TESK20.62846323
85IRAK20.62586063
86SGK2230.60712462
87SGK4940.60712462
88MAPK110.60608049
89MOS0.60023873
90PIM10.59238425
91PRKCQ0.59021565
92STK100.58281566
93YES10.56555245
94DMPK0.56137190
95MARK10.55971489
96TXK0.54748940
97CDK180.54695466
98CAMK40.54517438
99* HCK0.54431702
100MAP3K100.54110593
101TRIB30.52880712
102CDK150.51806440
103PRKD20.51399146
104MAP2K10.48999137
105* FYN0.48704932
106LRRK20.45625611
107IKBKE0.45349128
108CDK11A0.44887532
109RIPK10.44095920
110NME10.43997293
111EEF2K0.43990931
112CDK140.43783957
113DAPK30.42623351
114CAMK1G0.42541139
115MAPK40.42443269
116IRAK10.41884182
117JAK20.41415852
118CDK40.41250722
119MAP2K60.40641921
120RPS6KA30.40592143
121SIK10.39245609
122MAP3K140.38645452
123WNK10.37626811
124PINK10.36216772
125PRKCZ0.35824392
126MAP3K50.34651884
127MAPK100.34393206
128MAPK130.34357002
129DYRK1A0.34081009
130MAPK120.33212136
131UHMK10.33108104
132RPS6KC10.31894590
133RPS6KL10.31894590
134MAPK70.30897290
135LMTK20.30078013
136PRKCB0.28097390
137CLK10.27955869
138TAOK20.27698080
139KIT0.26944931
140PRKCA0.24757999
141JAK30.24212389
142TBK10.23755757
143CDC42BPA0.23638881

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.92396866
2Long-term potentiation_Homo sapiens_hsa047202.90484916
3Allograft rejection_Homo sapiens_hsa053302.88477891
4Nicotine addiction_Homo sapiens_hsa050332.81674080
5Graft-versus-host disease_Homo sapiens_hsa053322.70623530
6Autoimmune thyroid disease_Homo sapiens_hsa053202.64173412
7Circadian entrainment_Homo sapiens_hsa047132.58375732
8Synaptic vesicle cycle_Homo sapiens_hsa047212.57757916
9Amphetamine addiction_Homo sapiens_hsa050312.47506643
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.35826498
11Glutamatergic synapse_Homo sapiens_hsa047242.28738580
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.21859340
13Morphine addiction_Homo sapiens_hsa050322.19231354
14Staphylococcus aureus infection_Homo sapiens_hsa051502.14329968
15Salivary secretion_Homo sapiens_hsa049702.11117226
16Asthma_Homo sapiens_hsa053102.08929696
17GABAergic synapse_Homo sapiens_hsa047272.01116231
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.95365049
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.94970790
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.91287093
21Dopaminergic synapse_Homo sapiens_hsa047281.90401548
22Gastric acid secretion_Homo sapiens_hsa049711.85731503
23Cholinergic synapse_Homo sapiens_hsa047251.81459470
24Oxytocin signaling pathway_Homo sapiens_hsa049211.72561865
25Antigen processing and presentation_Homo sapiens_hsa046121.70210560
26Insulin secretion_Homo sapiens_hsa049111.67206346
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.62735288
28Renin secretion_Homo sapiens_hsa049241.61610463
29Viral myocarditis_Homo sapiens_hsa054161.58791162
30Acute myeloid leukemia_Homo sapiens_hsa052211.57188829
31Influenza A_Homo sapiens_hsa051641.57066780
32Measles_Homo sapiens_hsa051621.56897905
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.53081078
34* Calcium signaling pathway_Homo sapiens_hsa040201.53045546
35Toxoplasmosis_Homo sapiens_hsa051451.50621786
36Long-term depression_Homo sapiens_hsa047301.45139046
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.44818961
38Cocaine addiction_Homo sapiens_hsa050301.43040382
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42378410
40Hematopoietic cell lineage_Homo sapiens_hsa046401.42094703
41Glioma_Homo sapiens_hsa052141.39242162
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37202122
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36009289
44* GnRH signaling pathway_Homo sapiens_hsa049121.35432029
45Herpes simplex infection_Homo sapiens_hsa051681.32654979
46B cell receptor signaling pathway_Homo sapiens_hsa046621.32144767
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28527285
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27780853
49cAMP signaling pathway_Homo sapiens_hsa040241.26180416
50Type II diabetes mellitus_Homo sapiens_hsa049301.20382128
51Nitrogen metabolism_Homo sapiens_hsa009101.19022669
52Other glycan degradation_Homo sapiens_hsa005111.16608626
53Serotonergic synapse_Homo sapiens_hsa047261.16089100
54Taste transduction_Homo sapiens_hsa047421.11484973
55Jak-STAT signaling pathway_Homo sapiens_hsa046301.10771583
56VEGF signaling pathway_Homo sapiens_hsa043701.10404521
57Malaria_Homo sapiens_hsa051441.10339909
58* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09393870
59Collecting duct acid secretion_Homo sapiens_hsa049661.07696037
60Estrogen signaling pathway_Homo sapiens_hsa049151.07448296
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07033257
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05358533
63cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04364024
64Hepatitis C_Homo sapiens_hsa051601.04310396
65Gap junction_Homo sapiens_hsa045401.03988554
66* Hepatitis B_Homo sapiens_hsa051611.01449008
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.98713934
68ErbB signaling pathway_Homo sapiens_hsa040120.98230930
69African trypanosomiasis_Homo sapiens_hsa051430.97919575
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.97046633
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95009859
72Phagosome_Homo sapiens_hsa041450.94007406
73T cell receptor signaling pathway_Homo sapiens_hsa046600.92375119
74Chronic myeloid leukemia_Homo sapiens_hsa052200.91768275
75Osteoclast differentiation_Homo sapiens_hsa043800.91565919
76Non-small cell lung cancer_Homo sapiens_hsa052230.90026442
77* Phospholipase D signaling pathway_Homo sapiens_hsa040720.88916094
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87711069
79Choline metabolism in cancer_Homo sapiens_hsa052310.87563520
80Pancreatic cancer_Homo sapiens_hsa052120.86834274
81* Chemokine signaling pathway_Homo sapiens_hsa040620.85526620
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.84860667
83Apoptosis_Homo sapiens_hsa042100.84608155
84Dorso-ventral axis formation_Homo sapiens_hsa043200.83129238
85* Leukocyte transendothelial migration_Homo sapiens_hsa046700.82395818
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80601327
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80287950
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79827567
89Epstein-Barr virus infection_Homo sapiens_hsa051690.79715232
90Melanogenesis_Homo sapiens_hsa049160.79553325
91Legionellosis_Homo sapiens_hsa051340.79331616
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79089897
93MAPK signaling pathway_Homo sapiens_hsa040100.75819505
94Type I diabetes mellitus_Homo sapiens_hsa049400.74793172
95Tuberculosis_Homo sapiens_hsa051520.73976227
96Pancreatic secretion_Homo sapiens_hsa049720.73873808
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70709669
98Renal cell carcinoma_Homo sapiens_hsa052110.70482682
99Inositol phosphate metabolism_Homo sapiens_hsa005620.67980940
100Rap1 signaling pathway_Homo sapiens_hsa040150.67371314
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.66871140
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66720855
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66635779
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66508188
105Thyroid hormone synthesis_Homo sapiens_hsa049180.66069496
106Platelet activation_Homo sapiens_hsa046110.65826547
107mTOR signaling pathway_Homo sapiens_hsa041500.63478913
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63354910
109Endocytosis_Homo sapiens_hsa041440.61470886
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61420844
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60630710
112Viral carcinogenesis_Homo sapiens_hsa052030.60286757
113Glucagon signaling pathway_Homo sapiens_hsa049220.59775180
114Leishmaniasis_Homo sapiens_hsa051400.59771614
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58189463
116Oocyte meiosis_Homo sapiens_hsa041140.57762718
117HTLV-I infection_Homo sapiens_hsa051660.56809364
118Axon guidance_Homo sapiens_hsa043600.56693749
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55077419
120Primary immunodeficiency_Homo sapiens_hsa053400.54050535
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.52739504
122Prion diseases_Homo sapiens_hsa050200.52301296
123Vibrio cholerae infection_Homo sapiens_hsa051100.51152379
124Ras signaling pathway_Homo sapiens_hsa040140.50489188
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50408616
126Lysosome_Homo sapiens_hsa041420.46228579
127Salmonella infection_Homo sapiens_hsa051320.46159051
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45805216
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44882316
130Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44717992
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44403176
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.43775601
133FoxO signaling pathway_Homo sapiens_hsa040680.43485286
134Prolactin signaling pathway_Homo sapiens_hsa049170.43248928
135Rheumatoid arthritis_Homo sapiens_hsa053230.39949365
136Shigellosis_Homo sapiens_hsa051310.39945533
137Colorectal cancer_Homo sapiens_hsa052100.39631141
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39276542
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38458130
140Dilated cardiomyopathy_Homo sapiens_hsa054140.37805912
141HIF-1 signaling pathway_Homo sapiens_hsa040660.37276713
142Bile secretion_Homo sapiens_hsa049760.36738150
143Endometrial cancer_Homo sapiens_hsa052130.35028732
144TNF signaling pathway_Homo sapiens_hsa046680.34124290
145Pertussis_Homo sapiens_hsa051330.33373221

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