PTH1R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)8.30198651
2drug transmembrane transport (GO:0006855)8.19823975
3aminoglycoside antibiotic metabolic process (GO:0030647)7.92660188
4drug transport (GO:0015893)6.90521140
5lysine catabolic process (GO:0006554)6.82404846
6lysine metabolic process (GO:0006553)6.82404846
7organic cation transport (GO:0015695)6.49247305
8phosphate ion transport (GO:0006817)6.46515894
9glyoxylate metabolic process (GO:0046487)5.90276321
10glomerular basement membrane development (GO:0032836)5.80650694
11glomerular visceral epithelial cell development (GO:0072015)5.54730882
12drug catabolic process (GO:0042737)5.49008778
13exogenous drug catabolic process (GO:0042738)5.47454159
14quaternary ammonium group transport (GO:0015697)5.43828580
15phosphate ion transmembrane transport (GO:0035435)5.28342491
16cysteine metabolic process (GO:0006534)5.20956849
17response to mercury ion (GO:0046689)5.16270944
18excretion (GO:0007588)5.14714687
19glomerular epithelial cell development (GO:0072310)4.85250570
20tricarboxylic acid metabolic process (GO:0072350)4.75766973
21renal absorption (GO:0070293)4.61938310
22vitamin D metabolic process (GO:0042359)4.58548543
23short-chain fatty acid metabolic process (GO:0046459)4.42113691
24aspartate family amino acid catabolic process (GO:0009068)4.39657224
25metanephric nephron tubule development (GO:0072234)4.31871664
26metanephric tubule development (GO:0072170)4.31871664
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.26647795
28L-phenylalanine metabolic process (GO:0006558)4.26647795
29cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.22920858
30L-phenylalanine catabolic process (GO:0006559)4.16385335
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.16385335
32nonribosomal peptide biosynthetic process (GO:0019184)4.14791851
33trivalent inorganic anion homeostasis (GO:0072506)4.08683593
34phosphate ion homeostasis (GO:0055062)4.08683593
35aromatic amino acid family catabolic process (GO:0009074)4.08638785
36branched-chain amino acid metabolic process (GO:0009081)4.07314648
37metanephric epithelium development (GO:0072207)4.06642635
38homocysteine metabolic process (GO:0050667)4.01681483
39metanephric nephron epithelium development (GO:0072243)4.01660067
40proline metabolic process (GO:0006560)3.97749214
41tryptophan catabolic process (GO:0006569)3.96895933
42indole-containing compound catabolic process (GO:0042436)3.96895933
43indolalkylamine catabolic process (GO:0046218)3.96895933
44amino-acid betaine transport (GO:0015838)3.96297613
45carnitine transport (GO:0015879)3.96297613
46serine family amino acid catabolic process (GO:0009071)3.96133640
47fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.95470545
48complement activation, alternative pathway (GO:0006957)3.95170119
49cellular response to vitamin D (GO:0071305)3.93178354
50cellular modified amino acid catabolic process (GO:0042219)3.86387307
51valine metabolic process (GO:0006573)3.82409414
52cardiac myofibril assembly (GO:0055003)3.76253933
53cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.73879679
54tryptophan metabolic process (GO:0006568)3.73050940
55ethanol oxidation (GO:0006069)3.72739178
56glutathione biosynthetic process (GO:0006750)3.70104819
572-oxoglutarate metabolic process (GO:0006103)3.66093737
58response to phenylpropanoid (GO:0080184)3.64852139
59toxin transport (GO:1901998)3.63713389
60modified amino acid transport (GO:0072337)3.62665221
61serine family amino acid metabolic process (GO:0009069)3.62528842
62amino-acid betaine metabolic process (GO:0006577)3.61671539
63keratan sulfate catabolic process (GO:0042340)3.54527550
64response to parathyroid hormone (GO:0071107)3.53867249
65glucuronate metabolic process (GO:0019585)3.51813597
66uronic acid metabolic process (GO:0006063)3.51813597
67fatty acid beta-oxidation (GO:0006635)3.51516010
68glucocorticoid biosynthetic process (GO:0006704)3.45309468
69cellular glucuronidation (GO:0052695)3.42081346
70epoxygenase P450 pathway (GO:0019373)3.41777848
714-hydroxyproline metabolic process (GO:0019471)3.41328687
72acetyl-CoA metabolic process (GO:0006084)3.38904469
73nephron tubule development (GO:0072080)3.38094262
74regulation of apoptotic process involved in morphogenesis (GO:1902337)3.37488874
75cell communication by electrical coupling (GO:0010644)3.37183023
76branched-chain amino acid catabolic process (GO:0009083)3.36869268
77regulation of cardioblast differentiation (GO:0051890)3.36401365
78glomerulus development (GO:0032835)3.31136189
79nephron epithelium morphogenesis (GO:0072088)3.29958302
80nephron tubule morphogenesis (GO:0072078)3.29958302
81fatty acid oxidation (GO:0019395)3.28819640
82myofibril assembly (GO:0030239)3.26924361
83fructose metabolic process (GO:0006000)3.26470766
84regulation of protein activation cascade (GO:2000257)3.25661032
85response to magnesium ion (GO:0032026)3.25354845
86cellular response to vitamin (GO:0071295)3.23992841
87regulation of complement activation (GO:0030449)3.22055425
88glycoside metabolic process (GO:0016137)3.21735946
89polyol transport (GO:0015791)3.21471506
90lipid oxidation (GO:0034440)3.21328565
91cellular ketone body metabolic process (GO:0046950)3.19704069
92carnitine metabolic process (GO:0009437)3.14234115
93cell migration involved in heart development (GO:0060973)3.13689825
94omega-hydroxylase P450 pathway (GO:0097267)3.13041836
95response to lead ion (GO:0010288)3.12722993
96chondrocyte development (GO:0002063)3.11374051
97collagen fibril organization (GO:0030199)3.10320527
98cellular amino acid catabolic process (GO:0009063)3.08730188
99peptide catabolic process (GO:0043171)3.05297368
100alpha-amino acid catabolic process (GO:1901606)3.03823275
101kynurenine metabolic process (GO:0070189)3.02983824
102renal tubule morphogenesis (GO:0061333)3.02726458
103glutamate metabolic process (GO:0006536)3.02408145
104vitamin transport (GO:0051180)3.02151186
105NADH metabolic process (GO:0006734)3.00919981
106regulation of plasminogen activation (GO:0010755)3.00381255
107nephron epithelium development (GO:0072009)2.99327558
108response to growth hormone (GO:0060416)2.98811988
109outflow tract septum morphogenesis (GO:0003148)2.97298685
110renal tubule development (GO:0061326)2.93864988
111aromatic amino acid family metabolic process (GO:0009072)2.91344214
112sulfur amino acid catabolic process (GO:0000098)2.90675196
113cardiac chamber formation (GO:0003207)2.90462421
114sodium-independent organic anion transport (GO:0043252)2.89576834
115response to water (GO:0009415)2.88373788
116peptide biosynthetic process (GO:0043043)2.88222765
117cellular response to epinephrine stimulus (GO:0071872)2.87855562
118serine family amino acid biosynthetic process (GO:0009070)2.87715803
119drug metabolic process (GO:0017144)2.87367568
120cardiac muscle contraction (GO:0060048)2.86460328
121cellular sodium ion homeostasis (GO:0006883)2.82523134
122triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.81190752
123negative regulation of cholesterol transport (GO:0032375)2.79617313
124negative regulation of sterol transport (GO:0032372)2.79617313
125regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.79062833
126ethanol metabolic process (GO:0006067)2.76967460
127adhesion of symbiont to host cell (GO:0044650)2.71922823
128virion attachment to host cell (GO:0019062)2.71922823
129regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.71631287
130cell volume homeostasis (GO:0006884)2.70035836
131negative regulation of catenin import into nucleus (GO:0035414)2.69141424
132negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.68953579
133sodium ion export (GO:0071436)2.68350121
134sarcomere organization (GO:0045214)2.63934334
135response to epinephrine (GO:0071871)2.62580629
136cytoskeletal anchoring at plasma membrane (GO:0007016)2.61767388
137regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.61011162
138positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.60770394
139adhesion of symbiont to host (GO:0044406)2.60195380
140cellular response to cadmium ion (GO:0071276)2.59106978
141membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.57948700
142regulation of actin filament-based movement (GO:1903115)2.57774114
143cGMP-mediated signaling (GO:0019934)2.57325046
144cell communication involved in cardiac conduction (GO:0086065)2.56939461
145ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.56443465
146cardiac muscle hypertrophy (GO:0003300)2.55662086
147opsonization (GO:0008228)2.49826490
148response to dietary excess (GO:0002021)2.48671034
149glucocorticoid metabolic process (GO:0008211)2.47573672
150cardiac ventricle formation (GO:0003211)2.46157189
151cardiac muscle tissue morphogenesis (GO:0055008)2.42413911
152synaptic vesicle docking involved in exocytosis (GO:0016081)2.42275823
153striated muscle hypertrophy (GO:0014897)2.40829715
154cellular response to monoamine stimulus (GO:0071868)2.40490107
155cellular response to catecholamine stimulus (GO:0071870)2.40490107
156positive regulation of triglyceride lipase activity (GO:0061365)2.36754470
157positive regulation of lipoprotein lipase activity (GO:0051006)2.36754470
158actin-myosin filament sliding (GO:0033275)2.35769319
159muscle filament sliding (GO:0030049)2.35769319
160regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.34946886
161blood coagulation, intrinsic pathway (GO:0007597)2.33344140
162oxaloacetate metabolic process (GO:0006107)2.32971588
163atrial septum morphogenesis (GO:0060413)2.32691757
164myelination in peripheral nervous system (GO:0022011)2.32389955
165peripheral nervous system axon ensheathment (GO:0032292)2.32389955
166regulation of the force of heart contraction (GO:0002026)2.31516041
167urea metabolic process (GO:0019627)2.31301550
168cardiac muscle hypertrophy in response to stress (GO:0014898)2.30541381
169muscle hypertrophy in response to stress (GO:0003299)2.30541381
170cardiac muscle adaptation (GO:0014887)2.30541381
171regulation of female receptivity (GO:0045924)2.30029102
172sodium ion homeostasis (GO:0055078)2.29711281
173fatty acid homeostasis (GO:0055089)2.28161186
174triglyceride homeostasis (GO:0070328)2.26985427
175acylglycerol homeostasis (GO:0055090)2.26985427
176regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.26591241
177muscle tissue morphogenesis (GO:0060415)2.25208182
178regulation of fibrinolysis (GO:0051917)2.23679044
179protein carboxylation (GO:0018214)2.23070041
180peptidyl-glutamic acid carboxylation (GO:0017187)2.23070041
181triglyceride catabolic process (GO:0019433)2.22570372

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.68221789
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.40459262
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.10708117
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.94837003
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.85063310
6EZH2_22144423_ChIP-Seq_EOC_Human3.71108143
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.63049265
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.41955995
9CLOCK_20551151_ChIP-Seq_293T_Human3.20827346
10LXR_22158963_ChIP-Seq_LIVER_Mouse3.07121334
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.69890811
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.63961107
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.63663545
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.50229235
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.44396211
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.26830883
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.23741533
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.19711344
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.06611500
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.03895989
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.03441252
22CDX2_20551321_ChIP-Seq_CACO-2_Human1.98783297
23* EZH2_27294783_Chip-Seq_ESCs_Mouse1.96605079
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.93479718
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.89936486
26DROSHA_22980978_ChIP-Seq_HELA_Human1.89112253
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.88825495
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88061469
29ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.83149636
30* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78048725
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.77627707
32AR_21909140_ChIP-Seq_LNCAP_Human1.76513662
33SALL4_18804426_ChIP-ChIP_XEN_Mouse1.70451770
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.67111052
35ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.61275239
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.61003122
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.57782147
38ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.55463520
39EP300_21415370_ChIP-Seq_HL-1_Mouse1.49239541
40CTCF_27219007_Chip-Seq_Bcells_Human1.48855534
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.48192303
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.47489786
43LXR_22292898_ChIP-Seq_THP-1_Human1.47437783
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45930783
45* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.43756483
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43089828
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.42389422
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36936266
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35138367
50* TBX20_22328084_ChIP-Seq_HEART_Mouse1.34968994
51* TBX20_22080862_ChIP-Seq_HEART_Mouse1.34968994
52FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.34660448
53* RING1B_27294783_Chip-Seq_ESCs_Mouse1.34425744
54ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30589202
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28837288
56PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.28160656
57CJUN_26792858_Chip-Seq_BT549_Human1.25058285
58FOXA2_19822575_ChIP-Seq_HepG2_Human1.24701308
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24309628
60RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24309628
61RACK7_27058665_Chip-Seq_MCF-7_Human1.22755545
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21966053
63EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21072313
64PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20911208
65GATA4_25053715_ChIP-Seq_YYC3_Human1.20887263
66ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20800657
67NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20398245
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19740353
69SOX2_20726797_ChIP-Seq_SW620_Human1.18453461
70FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14083324
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13527690
72* RING1B_27294783_Chip-Seq_NPCs_Mouse1.13213857
73TP53_20018659_ChIP-ChIP_R1E_Mouse1.12620238
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12480837
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11879190
76RARB_27405468_Chip-Seq_BRAIN_Mouse1.11618071
77RXR_22108803_ChIP-Seq_LS180_Human1.11555632
78HNF4A_19822575_ChIP-Seq_HepG2_Human1.07920927
79MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07368217
80* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07116570
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06198172
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05844836
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05703954
84TET1_21490601_ChIP-Seq_MESCs_Mouse1.05630251
85P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03594869
86SMC4_20622854_ChIP-Seq_HELA_Human1.02671100
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02502442
88SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01791072
89SMAD3_21741376_ChIP-Seq_HESCs_Human1.01473051
90STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.00241858
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99279557
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98826731
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97774207
94CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97618166
95* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97530358
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96295022
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95963963
98SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95416762
99SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94946886
100PIAS1_25552417_ChIP-Seq_VCAP_Human0.94305896
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94176847
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93072685
103EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92912065
104EGR1_19032775_ChIP-ChIP_M12_Human0.91608761
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90183533
106ISL1_27105846_Chip-Seq_CPCs_Mouse0.89728245
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89444301
108SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.87892939
109* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.87353186
110CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87034634
111SA1_22415368_ChIP-Seq_MEFs_Mouse0.86977992
112CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86794474
113SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.86319126
114ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.86196538
115NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85635186
116NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85635186
117EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85304852
118TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.84614742
119ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84411157
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84224460
121OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84021475
122MYC_27129775_Chip-Seq_CORNEA_Mouse0.83924433
123GATA6_25053715_ChIP-Seq_YYC3_Human0.83356339
124SOX9_24532713_ChIP-Seq_HFSC_Mouse0.83174496
125KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83128905
126SMC3_22415368_ChIP-Seq_MEFs_Mouse0.82815507
127CSB_26484114_Chip-Seq_FIBROBLAST_Human0.82732563
128RAD21_21589869_ChIP-Seq_MESCs_Mouse0.82028498
129SMC1_22415368_ChIP-Seq_MEFs_Mouse0.81808133
130SMAD4_21741376_ChIP-Seq_HESCs_Human0.81632148
131* EZH2_27304074_Chip-Seq_ESCs_Mouse0.80760581
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.79820164
133P68_20966046_ChIP-Seq_HELA_Human0.79354081
134MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79264435
135CBX2_27304074_Chip-Seq_ESCs_Mouse0.79222970
136NR3C1_23031785_ChIP-Seq_PC12_Mouse0.79106788
137PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.79020611
138* TET1_21451524_ChIP-Seq_MESCs_Mouse0.78649088
139* KDM2B_26808549_Chip-Seq_K562_Human0.78266786
140TP53_23651856_ChIP-Seq_MEFs_Mouse0.77434917
141ELK3_25401928_ChIP-Seq_HUVEC_Human0.76819589
142REST_21632747_ChIP-Seq_MESCs_Mouse0.76356414
143TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75997285
144ATF3_27146783_Chip-Seq_COLON_Human0.75705278
145GBX2_23144817_ChIP-Seq_PC3_Human0.75371096
146DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.74414001

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.12537085
2MP0004043_abnormal_pH_regulation4.43386694
3MP0002139_abnormal_hepatobiliary_system4.15048361
4MP0005332_abnormal_amino_acid4.13216203
5MP0004019_abnormal_vitamin_homeostasis3.75593209
6MP0009643_abnormal_urine_homeostasis3.22121411
7MP0003195_calcinosis3.10839629
8MP0004272_abnormal_basement_membrane2.98121169
9MP0001958_emphysema2.80074436
10MP0005503_abnormal_tendon_morphology2.78759363
11MP0002138_abnormal_hepatobiliary_system2.66752738
12MP0002136_abnormal_kidney_physiology2.61411181
13MP0003283_abnormal_digestive_organ2.60945551
14MP0001756_abnormal_urination2.54454977
15MP0002837_dystrophic_cardiac_calcinosis2.43442284
16* MP0001765_abnormal_ion_homeostasis2.43309447
17MP0004859_abnormal_synaptic_plasticity2.15716985
18MP0005377_hearing/vestibular/ear_phenot2.10172915
19MP0003878_abnormal_ear_physiology2.10172915
20MP0004215_abnormal_myocardial_fiber2.08116085
21MP0003646_muscle_fatigue2.05037595
22MP0009384_cardiac_valve_regurgitation1.95664131
23* MP0005636_abnormal_mineral_homeostasis1.94999940
24MP0003252_abnormal_bile_duct1.94517134
25* MP0002896_abnormal_bone_mineralization1.93126055
26MP0008438_abnormal_cutaneous_collagen1.92827257
27MP0008875_abnormal_xenobiotic_pharmacok1.89089017
28* MP0000163_abnormal_cartilage_morphology1.86266584
29MP0004130_abnormal_muscle_cell1.83021095
30* MP0002115_abnormal_skeleton_extremities1.80375307
31MP0002282_abnormal_trachea_morphology1.78400922
32MP0005365_abnormal_bile_salt1.78278723
33MP0009250_abnormal_appendicular_skeleto1.70103336
34MP0003137_abnormal_impulse_conducting1.68911847
35MP0001542_abnormal_bone_strength1.68002482
36MP0003879_abnormal_hair_cell1.67372046
37MP0005085_abnormal_gallbladder_physiolo1.67192887
38MP0002249_abnormal_larynx_morphology1.66657227
39MP0005623_abnormal_meninges_morphology1.63239345
40MP0002089_abnormal_postnatal_growth/wei1.61601321
41MP0005330_cardiomyopathy1.57667382
42MP0003705_abnormal_hypodermis_morpholog1.55430347
43MP0006138_congestive_heart_failure1.52287971
44MP0002933_joint_inflammation1.45344961
45MP0004134_abnormal_chest_morphology1.43090694
46MP0002971_abnormal_brown_adipose1.37089446
47MP0008961_abnormal_basal_metabolism1.35133894
48MP0000230_abnormal_systemic_arterial1.34645690
49* MP0002113_abnormal_skeleton_development1.33840080
50MP0002972_abnormal_cardiac_muscle1.29137874
51MP0005666_abnormal_adipose_tissue1.29108975
52MP0003942_abnormal_urinary_system1.28684866
53MP0002135_abnormal_kidney_morphology1.26238588
54MP0000566_synostosis1.24499586
55MP0004087_abnormal_muscle_fiber1.24468787
56MP0010630_abnormal_cardiac_muscle1.23849676
57MP0005084_abnormal_gallbladder_morpholo1.22180665
58MP0005275_abnormal_skin_tensile1.21597363
59MP0001544_abnormal_cardiovascular_syste1.18436518
60MP0005385_cardiovascular_system_phenoty1.18436518
61MP0009780_abnormal_chondrocyte_physiolo1.17385897
62MP0003795_abnormal_bone_structure1.16721845
63MP0003806_abnormal_nucleotide_metabolis1.16438390
64MP0000534_abnormal_ureter_morphology1.15884951
65MP0005319_abnormal_enzyme/_coenzyme1.15867025
66MP0002108_abnormal_muscle_morphology1.15345912
67MP0005058_abnormal_lysosome_morphology1.15278819
68MP0002127_abnormal_cardiovascular_syste1.14987489
69MP0004085_abnormal_heartbeat1.13171260
70MP0000538_abnormal_urinary_bladder1.12789913
71MP0005620_abnormal_muscle_contractility1.12255952
72MP0003329_amyloid_beta_deposits1.10905425
73MP0003690_abnormal_glial_cell1.07069794
74MP0010030_abnormal_orbit_morphology1.06456459
75MP0003186_abnormal_redox_activity1.05252621
76MP0005508_abnormal_skeleton_morphology1.02349935
77MP0000751_myopathy1.00944170
78MP0004084_abnormal_cardiac_muscle1.00572389
79MP0000003_abnormal_adipose_tissue0.99132927
80MP0005584_abnormal_enzyme/coenzyme_acti0.97907453
81MP0005451_abnormal_body_composition0.97090608
82MP0003635_abnormal_synaptic_transmissio0.96242575
83MP0001270_distended_abdomen0.95918692
84MP0003279_aneurysm0.95731743
85MP0005369_muscle_phenotype0.95162164
86MP0001177_atelectasis0.94982457
87MP0002168_other_aberrant_phenotype0.93476336
88MP0005670_abnormal_white_adipose0.93197570
89MP0000013_abnormal_adipose_tissue0.91238987
90* MP0002998_abnormal_bone_remodeling0.90857207
91MP0004185_abnormal_adipocyte_glucose0.90841459
92MP0004510_myositis0.89395754
93MP0003880_abnormal_central_pattern0.88602519
94MP0001486_abnormal_startle_reflex0.87600367
95* MP0002109_abnormal_limb_morphology0.86833848
96MP0000759_abnormal_skeletal_muscle0.85581431
97MP0004270_analgesia0.85453160
98MP0009840_abnormal_foam_cell0.83279494
99MP0000750_abnormal_muscle_regeneration0.83243346
100MP0006054_spinal_hemorrhage0.82894279
101MP0000537_abnormal_urethra_morphology0.82757244
102MP0002928_abnormal_bile_duct0.81965944
103MP0004145_abnormal_muscle_electrophysio0.81395726
104MP0003567_abnormal_fetal_cardiomyocyte0.81301865
105MP0004885_abnormal_endolymph0.80646628
106MP0005595_abnormal_vascular_smooth0.79273651
107MP0005535_abnormal_body_temperature0.78671111
108MP0000767_abnormal_smooth_muscle0.78542154
109MP0000749_muscle_degeneration0.78114942
110MP0000462_abnormal_digestive_system0.77067720
111MP0009053_abnormal_anal_canal0.76052984
112MP0002064_seizures0.75729961
113MP0002106_abnormal_muscle_physiology0.75177044
114MP0001661_extended_life_span0.74923235
115MP0002063_abnormal_learning/memory/cond0.73944717
116MP0003941_abnormal_skin_development0.73550515
117MP0002932_abnormal_joint_morphology0.73165099
118MP0003300_gastrointestinal_ulcer0.71466451
119MP0002269_muscular_atrophy0.70455644
120MP0009115_abnormal_fat_cell0.69298115
121MP0002295_abnormal_pulmonary_circulatio0.68901008
122MP0005375_adipose_tissue_phenotype0.68668733
123MP0000639_abnormal_adrenal_gland0.68008053
124MP0003191_abnormal_cellular_cholesterol0.67092064
125MP0002118_abnormal_lipid_homeostasis0.66458303
126MP0002876_abnormal_thyroid_physiology0.65968959
127MP0003566_abnormal_cell_adhesion0.65748153
128MP0001879_abnormal_lymphatic_vessel0.65741565
129MP0004858_abnormal_nervous_system0.65106028
130MP0005390_skeleton_phenotype0.64695760
131MP0001915_intracranial_hemorrhage0.64634472
132MP0004484_altered_response_of0.64379621
133* MP0002116_abnormal_craniofacial_bone0.64027989
134MP0000747_muscle_weakness0.63446431
135MP0003123_paternal_imprinting0.62835754
136MP0010368_abnormal_lymphatic_system0.60506675
137MP0001299_abnormal_eye_distance/0.60432644
138MP0008775_abnormal_heart_ventricle0.57829232
139MP0000049_abnormal_middle_ear0.57310728
140MP0003385_abnormal_body_wall0.56867402
141MP0004036_abnormal_muscle_relaxation0.53884944
142MP0009672_abnormal_birth_weight0.53811340
143* MP0000432_abnormal_head_morphology0.53647717
144MP0003115_abnormal_respiratory_system0.53113504
145MP0010329_abnormal_lipoprotein_level0.52745979
146MP0003638_abnormal_response/metabolism_0.52049333
147MP0002111_abnormal_tail_morphology0.51639252

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)5.96188184
2Hypokalemic alkalosis (HP:0001949)5.58920431
3Metabolic alkalosis (HP:0200114)5.32235509
4Gout (HP:0001997)5.22687433
5Hypomagnesemia (HP:0002917)5.08752900
6Epiphyseal dysplasia (HP:0002656)5.06798290
7Polyuria (HP:0000103)4.94981291
8Hyperactive renin-angiotensin system (HP:0000841)4.84987801
9Complement deficiency (HP:0004431)4.82921954
10Abnormal urine output (HP:0012590)4.64322816
11Abnormality of chloride homeostasis (HP:0011422)4.50802681
12Abnormality of renal excretion (HP:0011036)4.37880059
13Abnormality of glutamine family amino acid metabolism (HP:0010902)4.32451169
14Abnormality of magnesium homeostasis (HP:0004921)4.29513746
15* Metaphyseal cupping (HP:0003021)4.23050707
16Proximal tubulopathy (HP:0000114)4.14204161
17Abnormal drinking behavior (HP:0030082)3.98241029
18Polydipsia (HP:0001959)3.98241029
19Increased purine levels (HP:0004368)3.93944640
20Hyperuricemia (HP:0002149)3.93944640
21* Delayed epiphyseal ossification (HP:0002663)3.89462265
22Premature rupture of membranes (HP:0001788)3.81208147
23Abnormality of complement system (HP:0005339)3.79612057
24Hydroxyprolinuria (HP:0003080)3.60558482
25Abnormality of proline metabolism (HP:0010907)3.60558482
26Alkalosis (HP:0001948)3.57794254
27Neonatal short-limb short stature (HP:0008921)3.57369764
28Hyperglycinuria (HP:0003108)3.54603351
29Irregular epiphyses (HP:0010582)3.50387682
30Tetany (HP:0001281)3.46459940
31Abnormality of renin-angiotensin system (HP:0000847)3.44606957
32Abnormality of purine metabolism (HP:0004352)3.41316763
33Cupped ribs (HP:0000887)3.24530490
34Renal salt wasting (HP:0000127)3.22632536
35Small epiphyses (HP:0010585)3.22189887
36Vitreoretinal degeneration (HP:0000655)3.19666207
37Hyperaldosteronism (HP:0000859)3.16359163
38Flat acetabular roof (HP:0003180)3.13555379
39Metaphyseal irregularity (HP:0003025)3.11786593
40Generalized aminoaciduria (HP:0002909)3.11734797
41Enlarged epiphyses (HP:0010580)3.11649860
42* Hypercalciuria (HP:0002150)3.11032699
43Sudden death (HP:0001699)2.99636948
44Genu varum (HP:0002970)2.97408017
45Mild short stature (HP:0003502)2.97110909
46Abnormality of monocarboxylic acid metabolism (HP:0010996)2.90416863
47Abnormality of glycine metabolism (HP:0010895)2.84009303
48Abnormality of serine family amino acid metabolism (HP:0010894)2.84009303
49Hypokalemia (HP:0002900)2.81125739
50Ventricular tachycardia (HP:0004756)2.77474240
51Hypoplastic ischia (HP:0003175)2.72697460
52Abnormality of aromatic amino acid family metabolism (HP:0004338)2.71239019
53Protuberant abdomen (HP:0001538)2.69550662
54Adrenal overactivity (HP:0002717)2.69188212
55Abnormality of urine glucose concentration (HP:0011016)2.64168779
56Glycosuria (HP:0003076)2.64168779
57Atrioventricular block (HP:0001678)2.62653984
58* Abnormal tarsal ossification (HP:0008369)2.61968864
59Ketoacidosis (HP:0001993)2.59967722
60Soft skin (HP:0000977)2.59616194
61Systemic lupus erythematosus (HP:0002725)2.58907621
62Vascular calcification (HP:0004934)2.56515760
63Myokymia (HP:0002411)2.53422518
64Atrial fibrillation (HP:0005110)2.52851121
65Shallow orbits (HP:0000586)2.50740947
66Coxa vara (HP:0002812)2.49533209
67Heart block (HP:0012722)2.47967993
68Flat capital femoral epiphysis (HP:0003370)2.47950974
69Renal tubular acidosis (HP:0001947)2.46012082
70Glomerulosclerosis (HP:0000096)2.44160025
71Abnormality of the ischium (HP:0003174)2.43561490
72Rickets (HP:0002748)2.43269305
73Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.42324335
74Abnormality of nucleobase metabolism (HP:0010932)2.42088518
75Abnormality of the vertebral endplates (HP:0005106)2.41798171
76Turricephaly (HP:0000262)2.40879724
77Cardiovascular calcification (HP:0011915)2.40544200
78Abnormal atrioventricular conduction (HP:0005150)2.40428226
79Hyperlipoproteinemia (HP:0010980)2.40091311
80Abnormal vertebral ossification (HP:0100569)2.39449614
81Aortic dissection (HP:0002647)2.38895851
82Focal segmental glomerulosclerosis (HP:0000097)2.38870258
83Osteoarthritis (HP:0002758)2.36728390
84Widely patent fontanelles and sutures (HP:0004492)2.36325974
85Ketosis (HP:0001946)2.36124240
86Cervical subluxation (HP:0003308)2.35537855
87Bundle branch block (HP:0011710)2.34570515
88Enlarged kidneys (HP:0000105)2.32853499
89Irregular vertebral endplates (HP:0003301)2.30165361
90Broad metatarsal (HP:0001783)2.26826393
91Primary atrial arrhythmia (HP:0001692)2.26488424
92* Platyspondyly (HP:0000926)2.26108940
93Coronal craniosynostosis (HP:0004440)2.26013074
94Abnormality of potassium homeostasis (HP:0011042)2.24712665
95Short femoral neck (HP:0100864)2.23808373
96Nephrolithiasis (HP:0000787)2.23768536
97Muscle fiber splitting (HP:0003555)2.23538953
98Tubular atrophy (HP:0000092)2.23275994
99Supraventricular tachycardia (HP:0004755)2.20981100
100Supraventricular arrhythmia (HP:0005115)2.19363158
101Right ventricular cardiomyopathy (HP:0011663)2.18403190
102Carpal bone hypoplasia (HP:0001498)2.17753791
103Fragile skin (HP:0001030)2.17077597
104Syncope (HP:0001279)2.15646413
105* Metaphyseal dysplasia (HP:0100255)2.15124744
106Ovoid vertebral bodies (HP:0003300)2.14651409
107Wide anterior fontanel (HP:0000260)2.14427266
108Chondrocalcinosis (HP:0000934)2.14062189
109Bladder diverticulum (HP:0000015)2.13814172
110Delayed CNS myelination (HP:0002188)2.12531850
111Vascular tortuosity (HP:0004948)2.12414919
112Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.10447084
113Abnormality of femoral epiphyses (HP:0006499)2.10447084
114Abnormality of the costochondral junction (HP:0000919)2.08854628
115Glomerulonephritis (HP:0000099)2.08269951
116Type 1 muscle fiber predominance (HP:0003803)2.07974306
117* Nephrocalcinosis (HP:0000121)2.07516228
118Abnormality of aspartate family amino acid metabolism (HP:0010899)2.05787036
119* Abnormality of carpal bone ossification (HP:0006257)2.05121359
120Aortic aneurysm (HP:0004942)2.04568929
121Abnormality of Sharpey fibers (HP:0100685)2.04380285
122Lipoatrophy (HP:0100578)2.03510056
123Protrusio acetabuli (HP:0003179)2.03235001
124Mitral valve prolapse (HP:0001634)2.02814680
125Hyperglycinemia (HP:0002154)2.02660950
126Beaking of vertebral bodies (HP:0004568)2.02066977
127Cerebral aneurysm (HP:0004944)2.01575061
128Hepatoblastoma (HP:0002884)1.98524915
129Abnormality of fatty-acid metabolism (HP:0004359)1.98299277
130Xanthomatosis (HP:0000991)1.98295721
131Infantile muscular hypotonia (HP:0008947)1.97963229
132Deep venous thrombosis (HP:0002625)1.97888156
133Hyporeflexia of lower limbs (HP:0002600)1.96970476
134Ectopia lentis (HP:0001083)1.96923754
135Malnutrition (HP:0004395)1.96513974
136Hypoalphalipoproteinemia (HP:0003233)1.95956750
137Neonatal onset (HP:0003623)1.95627893
138Abnormality of the epiphysis of the femoral head (HP:0010574)1.95587469
139Bell-shaped thorax (HP:0001591)1.94868101
140Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.94507617
141Abnormality of the middle phalanges of the toes (HP:0010183)1.94237200
142Flattened epiphyses (HP:0003071)1.94083573
143Increased variability in muscle fiber diameter (HP:0003557)1.93372811
144Facial shape deformation (HP:0011334)1.93199022
145Potter facies (HP:0002009)1.93199022
146* Hypophosphatemia (HP:0002148)1.93056930
147Hypoplasia of the odontoid process (HP:0003311)1.92445662
148Spinal cord compression (HP:0002176)1.88950366
149Disproportionate short-trunk short stature (HP:0003521)1.88483573
150Patent foramen ovale (HP:0001655)1.88412223
151* Lymphangioma (HP:0100764)1.86054219
152Aplasia involving bones of the extremities (HP:0009825)1.85576574
153Aplasia involving bones of the upper limbs (HP:0009823)1.85576574
154Aplasia of the phalanges of the hand (HP:0009802)1.85576574
155Atrophic scars (HP:0001075)1.85436343
156Ventricular arrhythmia (HP:0004308)1.84626972
157Prolonged partial thromboplastin time (HP:0003645)1.84017920
158Mitral stenosis (HP:0001718)1.83649347
159Action tremor (HP:0002345)1.82462662
160Arterial tortuosity (HP:0005116)1.81894054
161Thin ribs (HP:0000883)1.79358131
162Nephritis (HP:0000123)1.77628493
163Prolonged QT interval (HP:0001657)1.74694123
164Hyperextensible skin (HP:0000974)1.74653653
165Generalized muscle weakness (HP:0003324)1.72874160
166Ulnar bowing (HP:0003031)1.72310410
167Joint hemorrhage (HP:0005261)1.72119769
168Asymmetric septal hypertrophy (HP:0001670)1.68887356
169Round ear (HP:0100830)1.67352770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK48.84313641
2OXSR16.44285346
3WNK35.99557206
4STK394.49915908
5STK38L3.78323876
6BCKDK2.73908522
7DDR22.61599793
8NTRK32.19902902
9EPHA42.13023718
10PAK61.78212068
11TRIB31.75905478
12EPHB21.75666331
13DMPK1.70087811
14WNK11.69156087
15NTRK21.64004955
16LATS11.63083911
17MAP3K31.59134554
18NEK11.55533832
19TIE11.47892585
20MARK11.46727180
21LMTK21.43372701
22PDK21.40744914
23PDK31.38853568
24PDK41.38853568
25UHMK11.37688207
26FGFR21.31436079
27CAMK11.30638936
28SGK2231.27886447
29SGK4941.27886447
30AKT31.25162820
31MYLK1.24594460
32PAK41.24547974
33FGFR41.23745184
34OBSCN1.19409751
35DAPK21.19099603
36MARK21.13799894
37SIK11.11596402
38STK381.10736479
39MST41.06823316
40TGFBR21.06819678
41LATS21.05221399
42PHKG21.03179868
43PHKG11.03179868
44TESK10.98960488
45LRRK20.96980552
46CDC42BPA0.96593978
47PRKG20.94802865
48PDGFRA0.94543108
49ARAF0.94300754
50PRPF4B0.90380328
51MAP3K60.89931524
52GSK3A0.88225965
53GRK50.86605100
54CAMKK10.86402951
55DAPK30.84224577
56TYRO30.83465500
57ICK0.82109686
58NME10.77586637
59TGFBR10.77431062
60PTK60.76736664
61CAMK2B0.75800199
62CAMK2G0.74289624
63PTK20.74203537
64MST1R0.73307670
65PKN20.71012149
66MAPK70.70344470
67FER0.70004674
68SGK30.67977707
69CDK50.67020463
70RET0.66650422
71CAMK2D0.66193722
72STK240.64794808
73ROCK10.63505938
74EPHB10.61472169
75RIPK10.61372430
76PAK30.60740663
77CAMK2A0.60122305
78SGK20.59700216
79EEF2K0.59419711
80ERN10.59088758
81MAP3K70.58909996
82MINK10.57313975
83PIK3CA0.57214949
84MAP2K30.56695410
85ABL20.56608580
86STK30.56020115
87MUSK0.55071092
88PTK2B0.54688488
89DYRK1B0.54467216
90KDR0.53149061
91MAPK100.52932892
92MET0.52813023
93KSR20.49656562
94RPS6KA20.47424180
95PRKCI0.44991007
96NME20.43792602
97FLT30.42617881
98TAOK10.42267828
99RPS6KA30.42091762
100PRKCG0.41848249
101PINK10.41212351
102NEK90.40639286
103FGFR10.39487686
104SGK10.39130586
105PDPK10.37637488
106PRKAA10.37148062
107NTRK10.36148152
108PRKAA20.32196137
109PAK20.32084412
110MAPK120.31949285
111MAP3K110.29710187
112MTOR0.29208012
113MAPK110.28454093
114GRK60.26469141
115BMX0.25658504
116MAP2K10.22855210
117PRKCZ0.21302124
118PRKACG0.20657772
119AKT20.19682984
120PRKD20.17731604
121PRKD30.16966871
122MAP3K100.15277559
123IGF1R0.13742991
124ADRBK10.13385825
125PDK10.12817807
126PDGFRB0.12599906
127PRKCH0.11886330
128STK110.11723955
129KSR10.11270601
130INSR0.11219292
131SRC0.11045146
132STK100.10780723
133PRKACA0.09965024
134MAPK40.08331959
135PRKCD0.07882490
136ILK0.07770189
137TTN0.07304816
138PRKD10.07011353
139CAMK40.06826792
140ERBB20.06648171
141PRKCA0.06483211
142ROCK20.06006669
143PIM10.05792643

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.45467772
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.38820019
3Butanoate metabolism_Homo sapiens_hsa006503.23287327
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.10123459
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.09327311
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.09215112
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.94233349
8Propanoate metabolism_Homo sapiens_hsa006402.90124686
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.85666959
10Protein digestion and absorption_Homo sapiens_hsa049742.69207002
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.57661632
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.43286400
13Pyruvate metabolism_Homo sapiens_hsa006202.22857071
14Vitamin B6 metabolism_Homo sapiens_hsa007502.19460836
15ECM-receptor interaction_Homo sapiens_hsa045122.18371472
16Fatty acid degradation_Homo sapiens_hsa000712.16281496
17Peroxisome_Homo sapiens_hsa041462.12882284
18Tryptophan metabolism_Homo sapiens_hsa003802.07698214
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.91058820
20Vitamin digestion and absorption_Homo sapiens_hsa049771.86397706
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.85769746
22Sulfur metabolism_Homo sapiens_hsa009201.82864977
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70800222
24Dilated cardiomyopathy_Homo sapiens_hsa054141.65332002
25beta-Alanine metabolism_Homo sapiens_hsa004101.64889324
26Prion diseases_Homo sapiens_hsa050201.64054695
27Bile secretion_Homo sapiens_hsa049761.60537170
28Fatty acid metabolism_Homo sapiens_hsa012121.58746776
29Carbon metabolism_Homo sapiens_hsa012001.57412807
30Lysine degradation_Homo sapiens_hsa003101.54537429
31Arginine and proline metabolism_Homo sapiens_hsa003301.50290049
32Caffeine metabolism_Homo sapiens_hsa002321.48326469
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46826881
34Glutathione metabolism_Homo sapiens_hsa004801.46588206
35Collecting duct acid secretion_Homo sapiens_hsa049661.45768685
36Starch and sucrose metabolism_Homo sapiens_hsa005001.35971739
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.34782807
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.31290840
39Arginine biosynthesis_Homo sapiens_hsa002201.28229042
40PPAR signaling pathway_Homo sapiens_hsa033201.27256526
41Folate biosynthesis_Homo sapiens_hsa007901.25725448
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24281883
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22137488
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17140300
45Selenocompound metabolism_Homo sapiens_hsa004501.16129158
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14658091
47Nitrogen metabolism_Homo sapiens_hsa009101.10880033
48Other glycan degradation_Homo sapiens_hsa005111.09776188
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07289044
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.06973671
51Renin-angiotensin system_Homo sapiens_hsa046141.04935957
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02771301
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99900999
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96893750
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94740934
56* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92999687
57Biosynthesis of amino acids_Homo sapiens_hsa012300.92063355
58Focal adhesion_Homo sapiens_hsa045100.91172201
59Circadian entrainment_Homo sapiens_hsa047130.89853368
60Mineral absorption_Homo sapiens_hsa049780.89663495
61GABAergic synapse_Homo sapiens_hsa047270.87795156
62Phenylalanine metabolism_Homo sapiens_hsa003600.87048434
63Insulin secretion_Homo sapiens_hsa049110.82829174
64Renin secretion_Homo sapiens_hsa049240.81323194
65Synaptic vesicle cycle_Homo sapiens_hsa047210.80959058
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80272109
67Histidine metabolism_Homo sapiens_hsa003400.79533010
68Morphine addiction_Homo sapiens_hsa050320.79250338
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.79073426
70Ovarian steroidogenesis_Homo sapiens_hsa049130.77976118
71Amphetamine addiction_Homo sapiens_hsa050310.73324740
72Long-term potentiation_Homo sapiens_hsa047200.71565755
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70069708
74Fructose and mannose metabolism_Homo sapiens_hsa000510.68067259
75Glutamatergic synapse_Homo sapiens_hsa047240.67586905
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.67071286
77Thyroid hormone synthesis_Homo sapiens_hsa049180.66652948
78Hedgehog signaling pathway_Homo sapiens_hsa043400.66298382
79Glycerolipid metabolism_Homo sapiens_hsa005610.65531366
80Melanogenesis_Homo sapiens_hsa049160.64911478
81Cocaine addiction_Homo sapiens_hsa050300.62905731
82cAMP signaling pathway_Homo sapiens_hsa040240.59606275
83Glucagon signaling pathway_Homo sapiens_hsa049220.59214040
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58541203
85Chemical carcinogenesis_Homo sapiens_hsa052040.57825726
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.56823629
87Nicotine addiction_Homo sapiens_hsa050330.56738957
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.55371346
89Gap junction_Homo sapiens_hsa045400.52368513
90Tight junction_Homo sapiens_hsa045300.52124479
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.51039732
92Calcium signaling pathway_Homo sapiens_hsa040200.50071065
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50068369
94Oxidative phosphorylation_Homo sapiens_hsa001900.49851460
95Steroid biosynthesis_Homo sapiens_hsa001000.49805931
96Oxytocin signaling pathway_Homo sapiens_hsa049210.49366886
97Linoleic acid metabolism_Homo sapiens_hsa005910.48506797
98Dopaminergic synapse_Homo sapiens_hsa047280.47734468
99Metabolic pathways_Homo sapiens_hsa011000.47057323
100Fatty acid elongation_Homo sapiens_hsa000620.46559472
101Retinol metabolism_Homo sapiens_hsa008300.45163437
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45061158
103Cholinergic synapse_Homo sapiens_hsa047250.43496075
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43355917
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.42412328
106Insulin signaling pathway_Homo sapiens_hsa049100.42329997
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42150054
108Fatty acid biosynthesis_Homo sapiens_hsa000610.41937317
109Fat digestion and absorption_Homo sapiens_hsa049750.41011982
110Sphingolipid metabolism_Homo sapiens_hsa006000.39658241
111Small cell lung cancer_Homo sapiens_hsa052220.38391923
112Lysosome_Homo sapiens_hsa041420.36803751
113Bladder cancer_Homo sapiens_hsa052190.36775895
114Galactose metabolism_Homo sapiens_hsa000520.35693207
115Basal cell carcinoma_Homo sapiens_hsa052170.35390508
116Pentose phosphate pathway_Homo sapiens_hsa000300.35388642
117Amoebiasis_Homo sapiens_hsa051460.34336327
118Vibrio cholerae infection_Homo sapiens_hsa051100.33657179
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.32327598
120Arachidonic acid metabolism_Homo sapiens_hsa005900.32176985
121Sulfur relay system_Homo sapiens_hsa041220.29644021
122Hippo signaling pathway_Homo sapiens_hsa043900.29330183
123Insulin resistance_Homo sapiens_hsa049310.24523839
124Tyrosine metabolism_Homo sapiens_hsa003500.24385757
125Complement and coagulation cascades_Homo sapiens_hsa046100.24122812
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.23732143
127Gastric acid secretion_Homo sapiens_hsa049710.23382018
128Parkinsons disease_Homo sapiens_hsa050120.23260643
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21902376
130Proteoglycans in cancer_Homo sapiens_hsa052050.21173655
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.19836002
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.16443226
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.15274295
134Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.14212910
135Cardiac muscle contraction_Homo sapiens_hsa042600.12659878
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.12605632
137AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.11785630
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11707934
139AMPK signaling pathway_Homo sapiens_hsa041520.11221290
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.07949987

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