PTGS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of dendritic cell antigen processing and presentation (GO:0002604)4.84590570
2cell adhesion mediated by integrin (GO:0033627)4.77996117
3positive regulation of chemokine biosynthetic process (GO:0045080)4.74655596
4wound healing, spreading of epidermal cells (GO:0035313)4.55099531
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.50127313
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.50127313
7modulation by symbiont of host immune response (GO:0052553)4.50127313
8positive regulation by symbiont of host defense response (GO:0052509)4.50127313
9modulation by symbiont of host defense response (GO:0052031)4.50127313
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.50127313
11regulation of mononuclear cell migration (GO:0071675)4.30504963
12regulation of chronic inflammatory response (GO:0002676)4.19055199
13T-helper 1 type immune response (GO:0042088)4.15829621
14regulation of cytokine secretion involved in immune response (GO:0002739)3.97662290
15chronic inflammatory response (GO:0002544)3.92356087
16regulation of T-helper 2 cell differentiation (GO:0045628)3.82336637
17regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.82020047
18germinal center formation (GO:0002467)3.79410961
19response to peptidoglycan (GO:0032494)3.78949651
20regulation of chemokine biosynthetic process (GO:0045073)3.72473561
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.72331584
22response to protozoan (GO:0001562)3.71382352
23branching involved in labyrinthine layer morphogenesis (GO:0060670)3.70144166
24regulation of monocyte chemotaxis (GO:0090025)3.69770327
25defense response to protozoan (GO:0042832)3.68009717
26positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.67554610
27cellular response to interferon-alpha (GO:0035457)3.67445889
28chondrocyte proliferation (GO:0035988)3.66870495
29wound healing, spreading of cells (GO:0044319)3.61453399
30positive regulation of type 2 immune response (GO:0002830)3.61338109
31negative regulation of fatty acid transport (GO:2000192)3.60716761
32collagen fibril organization (GO:0030199)3.60010380
33lipopolysaccharide-mediated signaling pathway (GO:0031663)3.58952402
34regulation of podosome assembly (GO:0071801)3.55668617
35positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.54714558
36neutrophil activation involved in immune response (GO:0002283)3.51356034
37type I interferon signaling pathway (GO:0060337)3.50231727
38cellular response to type I interferon (GO:0071357)3.50231727
39positive regulation of T-helper cell differentiation (GO:0045624)3.46161929
40response to type I interferon (GO:0034340)3.45908993
41* positive regulation of acute inflammatory response (GO:0002675)3.44811441
42low-density lipoprotein particle clearance (GO:0034383)3.44061171
43regulation of interleukin-8 biosynthetic process (GO:0045414)3.43967925
44endodermal cell differentiation (GO:0035987)3.43520306
45regulation of T-helper cell differentiation (GO:0045622)3.36935927
46positive regulation of interferon-alpha production (GO:0032727)3.35593586
47positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.34641594
48positive regulation of endothelial cell apoptotic process (GO:2000353)3.34610061
49negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.33821754
50cellular response to lipopolysaccharide (GO:0071222)3.32172533
51positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.29777248
52regulation of membrane protein ectodomain proteolysis (GO:0051043)3.28261638
53regulation of interferon-alpha production (GO:0032647)3.26267691
54cellular response to molecule of bacterial origin (GO:0071219)3.25891509
55response to muramyl dipeptide (GO:0032495)3.25730048
56regulation of heterotypic cell-cell adhesion (GO:0034114)3.25200763
57regulation of vitamin D biosynthetic process (GO:0060556)3.24182023
58negative regulation of interleukin-12 production (GO:0032695)3.21621596
59* regulation of nitric oxide biosynthetic process (GO:0045428)3.20587682
60* positive regulation of heat generation (GO:0031652)3.17821219
61* regulation of NF-kappaB import into nucleus (GO:0042345)3.15060136
62macrophage activation involved in immune response (GO:0002281)3.14206599
63regulation of T-helper 1 cell differentiation (GO:0045625)3.14146283
64* regulation of fever generation (GO:0031620)3.10158420
65negative regulation of lipid storage (GO:0010888)3.09282652
66positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.09141372
67cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.08557039
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.07959824
69positive regulation of natural killer cell differentiation (GO:0032825)3.07008566
70negative regulation of growth of symbiont in host (GO:0044130)3.05956022
71negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.05956022
72modulation of growth of symbiont involved in interaction with host (GO:0044144)3.05956022
73regulation of growth of symbiont in host (GO:0044126)3.05956022
74regulation of interleukin-12 production (GO:0032655)3.05835852
75regulation of type 2 immune response (GO:0002828)3.05609495
76positive regulation of interleukin-17 production (GO:0032740)3.05581837
77positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.04714867
78positive regulation of chemokine production (GO:0032722)3.03979244
79negative regulation of nitric oxide biosynthetic process (GO:0045019)3.01723236
80positive regulation of monocyte chemotaxis (GO:0090026)2.97509374
81positive regulation of gamma-delta T cell activation (GO:0046645)2.97262902
82regulation of interferon-beta biosynthetic process (GO:0045357)2.96604347
83regulation of immunoglobulin secretion (GO:0051023)2.94474828
84regulation of macrophage cytokine production (GO:0010935)2.94098554
85apoptotic cell clearance (GO:0043277)2.93885085
86regulation of interleukin-6 production (GO:0032675)2.93305850
87immunoglobulin mediated immune response (GO:0016064)2.92736285
88regulation of antigen processing and presentation (GO:0002577)2.92091474
89positive regulation of interleukin-10 production (GO:0032733)2.91713199
90regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.91195979
91positive regulation of interferon-beta production (GO:0032728)2.89688037
92neutrophil mediated immunity (GO:0002446)2.88464218
93negative regulation of production of molecular mediator of immune response (GO:0002701)2.88236293
94cellular response to biotic stimulus (GO:0071216)2.87610409
95regulation of integrin activation (GO:0033623)2.87274338
96* regulation of heat generation (GO:0031650)2.87223800
97cellular extravasation (GO:0045123)2.86005483
98regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.85966577
99interferon-gamma-mediated signaling pathway (GO:0060333)2.84644243
100positive regulation of p38MAPK cascade (GO:1900745)2.84350364
101response to host immune response (GO:0052572)2.83155805
102response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.83155805
103positive regulation of toll-like receptor signaling pathway (GO:0034123)2.82647910
104positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.82429644
105positive regulation of macrophage cytokine production (GO:0060907)2.81970965
106* positive regulation of transcription factor import into nucleus (GO:0042993)2.81356172
107regulation of vitamin metabolic process (GO:0030656)2.80634404
108axon extension involved in axon guidance (GO:0048846)2.80272947
109neuron projection extension involved in neuron projection guidance (GO:1902284)2.80272947
110macrophage activation (GO:0042116)2.80028164
111detection of molecule of bacterial origin (GO:0032490)2.79042473
112cellular response to nicotine (GO:0071316)2.77869072
113cellular response to vitamin D (GO:0071305)2.77367412
114regulation of plasminogen activation (GO:0010755)2.77352192
115neutrophil activation (GO:0042119)2.77193062
116natural killer cell mediated cytotoxicity (GO:0042267)2.76913365
117natural killer cell mediated immunity (GO:0002228)2.76913365
118regulation of macrophage chemotaxis (GO:0010758)2.75631201
119negative regulation of interleukin-17 production (GO:0032700)2.74895985
120negative regulation of cytokine production involved in immune response (GO:0002719)2.72237785
121positive regulation of interleukin-6 production (GO:0032755)2.71933747
122regulation of interleukin-17 production (GO:0032660)2.71923353
123regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.71275451
124regulation of chemokine-mediated signaling pathway (GO:0070099)2.70338212
125positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.69900688
126negative regulation of organic acid transport (GO:0032891)2.69493082
127response to interferon-alpha (GO:0035455)2.69352991
128myeloid cell homeostasis (GO:0002262)2.68355697
129granulocyte activation (GO:0036230)2.66619474
130sequestering of extracellular ligand from receptor (GO:0035581)2.66564613
131skin morphogenesis (GO:0043589)2.65482753
132response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.64810752
133response to host (GO:0075136)2.64810752
134response to host defenses (GO:0052200)2.64810752
135positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.64362176
136positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.64080926
137regulation of interleukin-12 biosynthetic process (GO:0045075)2.60472071
138I-kappaB phosphorylation (GO:0007252)2.60383337
139positive regulation of cytokine biosynthetic process (GO:0042108)2.60154947
140NIK/NF-kappaB signaling (GO:0038061)2.60054940
141negative regulation of bone mineralization (GO:0030502)2.59980629
142regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.58594464
143positive regulation of macrophage activation (GO:0043032)2.56344626
144positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.55160866
145positive regulation of osteoblast proliferation (GO:0033690)2.55138945
146* positive regulation of NF-kappaB import into nucleus (GO:0042346)2.54796834
147regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.54638644
148substrate-dependent cell migration (GO:0006929)2.53321905
149* positive regulation of nitric oxide biosynthetic process (GO:0045429)2.53035843
150negative regulation of leukocyte chemotaxis (GO:0002689)2.52220697
151leukocyte aggregation (GO:0070486)2.51708541
152monocyte chemotaxis (GO:0002548)2.48676233
153respiratory burst (GO:0045730)2.48255171
154eosinophil chemotaxis (GO:0048245)2.48221486
155positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.47841551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.21786103
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.69344171
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.23833642
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.21241375
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.14687390
6EGR1_19374776_ChIP-ChIP_THP-1_Human4.08274041
7* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.68836317
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.50208336
9RARG_19884340_ChIP-ChIP_MEFs_Mouse3.40564105
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.38395642
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.35614074
12SMAD_19615063_ChIP-ChIP_OVARY_Human3.07231898
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.00277457
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.83515906
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.69687379
16* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69000557
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.63479230
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.55865992
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.45924591
20CJUN_26792858_Chip-Seq_BT549_Human2.22275178
21TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.21493382
22* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.20198397
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14998751
24* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.13530542
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.10364880
26SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.09376147
27SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.09376147
28RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.03139483
29* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.93475409
30* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.93475409
31CLOCK_20551151_ChIP-Seq_293T_Human1.89221299
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.88907365
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.87050670
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.80333627
35JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.77810790
36BRD4_25478319_ChIP-Seq_HGPS_Human1.74046781
37ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.69593992
38* SOX2_20726797_ChIP-Seq_SW620_Human1.66592355
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.66425899
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.65308896
41VDR_24787735_ChIP-Seq_THP-1_Human1.65193322
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64016062
43JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62550973
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.60248608
45SPI1_23127762_ChIP-Seq_K562_Human1.59282086
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.59069588
47SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.57548007
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56875461
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.54742490
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.53668696
51PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53405939
52* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51191440
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.51094066
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46673447
55SCL_19346495_ChIP-Seq_HPC-7_Human1.44100150
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40054994
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.37888269
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35682456
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35321925
60TP53_18474530_ChIP-ChIP_U2OS_Human1.34794012
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31059414
62FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29730436
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24772253
64CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.24441013
65VDR_21846776_ChIP-Seq_THP-1_Human1.23028295
66SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22893118
67TCF7_22412390_ChIP-Seq_EML_Mouse1.22157836
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.18055220
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.18055220
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.18055220
71UBF1/2_26484160_Chip-Seq_HMECs_Human1.16977738
72GATA1_22025678_ChIP-Seq_K562_Human1.16064991
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15449490
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15409350
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13184297
76PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11975733
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11689221
78FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10170029
79ATF3_27146783_Chip-Seq_COLON_Human1.09733532
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09226201
81* PU_27001747_Chip-Seq_BMDM_Mouse1.08650689
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08343174
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07700008
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07124549
85VDR_24763502_ChIP-Seq_THP-1_Human1.06409628
86CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05831764
87KDM2B_26808549_Chip-Seq_DND41_Human1.05560926
88GATA1_19941826_ChIP-Seq_K562_Human1.05306697
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03583001
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02768126
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02134800
92* TP53_16413492_ChIP-PET_HCT116_Human1.01743394
93SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01392728
94P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99594682
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99315011
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99267888
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98755945
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97950063
99P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97538641
100MYB_26560356_Chip-Seq_TH2_Human0.97531765
101GATA1_19941827_ChIP-Seq_MEL_Mouse0.97477025
102CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97201414
103EP300_21415370_ChIP-Seq_HL-1_Mouse0.96599697
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95821395
105EGR1_19032775_ChIP-ChIP_M12_Human0.95027664
106* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94134281
107SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93866017
108* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93078977
109MYB_26560356_Chip-Seq_TH1_Human0.92667081
110RUNX_20019798_ChIP-Seq_JUKART_Human0.91362216
111PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89902739
112GATA3_26560356_Chip-Seq_TH2_Human0.88873715
113CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88857581
114* TP63_23658742_ChIP-Seq_EP156T_Human0.88757684
115RUNX1_22412390_ChIP-Seq_EML_Mouse0.87243677
116UTX_26944678_Chip-Seq_JUKART_Human0.86193784
117GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86117461
118CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85351513
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84906260
120RXR_22108803_ChIP-Seq_LS180_Human0.84798531
121KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83122383
122LXR_22158963_ChIP-Seq_LIVER_Mouse0.82940890
123KDM2B_26808549_Chip-Seq_K562_Human0.82589600
124FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80966456
125TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.80821991
126WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.78847009
127GATA3_27048872_Chip-Seq_THYMUS_Human0.78231236
128TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78063247
129* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.77497409
130KLF5_25053715_ChIP-Seq_YYC3_Human0.76996529
131SOX9_24532713_ChIP-Seq_HFSC_Mouse0.73098098
132MAF_26560356_Chip-Seq_TH1_Human0.72593166
133SPI1_23547873_ChIP-Seq_NB4_Human0.72163812
134* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.70347456

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.82647523
2MP0005275_abnormal_skin_tensile3.07588941
3MP0003705_abnormal_hypodermis_morpholog2.94097653
4* MP0010352_gastrointestinal_tract_polyps2.69748952
5MP0009785_altered_susceptibility_to2.65254972
6* MP0003436_decreased_susceptibility_to2.53048948
7MP0003724_increased_susceptibility_to2.47305403
8MP0005503_abnormal_tendon_morphology2.44054694
9MP0006082_CNS_inflammation2.42199965
10* MP0001533_abnormal_skeleton_physiology2.32753010
11MP0003279_aneurysm2.29319174
12MP0003091_abnormal_cell_migration2.27172290
13MP0003566_abnormal_cell_adhesion2.26811965
14* MP0005023_abnormal_wound_healing2.22086214
15MP0002148_abnormal_hypersensitivity_rea2.12554092
16* MP0002419_abnormal_innate_immunity2.10312483
17MP0004947_skin_inflammation2.09903514
18MP0005451_abnormal_body_composition2.08261189
19MP0005623_abnormal_meninges_morphology2.08096230
20MP0001958_emphysema2.07909237
21MP0001348_abnormal_lacrimal_gland2.07520651
22MP0003448_altered_tumor_morphology2.07318898
23MP0001835_abnormal_antigen_presentation2.06443473
24MP0000343_altered_response_to2.02784336
25* MP0005000_abnormal_immune_tolerance2.01722438
26MP0004510_myositis2.00675042
27MP0005167_abnormal_blood-brain_barrier1.99128420
28MP0002933_joint_inflammation1.94133170
29MP0001853_heart_inflammation1.86085708
30MP0002998_abnormal_bone_remodeling1.85718713
31MP0002877_abnormal_melanocyte_morpholog1.81108876
32* MP0005390_skeleton_phenotype1.77277870
33MP0001790_abnormal_immune_system1.76312596
34MP0005387_immune_system_phenotype1.76312596
35MP0009840_abnormal_foam_cell1.74703184
36* MP0003303_peritoneal_inflammation1.72849544
37* MP0005025_abnormal_response_to1.65103063
38* MP0002332_abnormal_exercise_endurance1.64843152
39MP0003300_gastrointestinal_ulcer1.64482431
40* MP0005164_abnormal_response_to1.64468713
41MP0000685_abnormal_immune_system1.63759331
42MP0009278_abnormal_bone_marrow1.63338029
43MP0002254_reproductive_system_inflammat1.62894895
44MP0009764_decreased_sensitivity_to1.60872682
45MP0002295_abnormal_pulmonary_circulatio1.55449370
46MP0002282_abnormal_trachea_morphology1.54494394
47* MP0002452_abnormal_antigen_presenting1.54157131
48MP0001542_abnormal_bone_strength1.51889056
49MP0005257_abnormal_intraocular_pressure1.50239310
50MP0005076_abnormal_cell_differentiation1.50165494
51MP0001243_abnormal_dermal_layer1.46840459
52MP0000858_altered_metastatic_potential1.45547517
53MP0003656_abnormal_erythrocyte_physiolo1.44737421
54MP0003191_abnormal_cellular_cholesterol1.43609225
55MP0002405_respiratory_system_inflammati1.37924152
56MP0003453_abnormal_keratinocyte_physiol1.37734395
57MP0002896_abnormal_bone_mineralization1.35787743
58* MP0002723_abnormal_immune_serum1.34768880
59MP0001299_abnormal_eye_distance/1.33526892
60MP0005508_abnormal_skeleton_morphology1.33256829
61MP0003172_abnormal_lysosome_physiology1.30476666
62MP0002006_tumorigenesis1.26885046
63MP0003690_abnormal_glial_cell1.26418652
64MP0002060_abnormal_skin_morphology1.25003144
65* MP0001845_abnormal_inflammatory_respons1.24865491
66* MP0003075_altered_response_to1.24048521
67MP0004858_abnormal_nervous_system1.23930995
68* MP0003795_abnormal_bone_structure1.21181650
69MP0002139_abnormal_hepatobiliary_system1.18716708
70MP0004272_abnormal_basement_membrane1.18329878
71* MP0001800_abnormal_humoral_immune1.15902018
72MP0009384_cardiac_valve_regurgitation1.14453793
73MP0006054_spinal_hemorrhage1.13671959
74* MP0000716_abnormal_immune_system1.13247202
75MP0005058_abnormal_lysosome_morphology1.12904266
76MP0000733_abnormal_muscle_development1.12792640
77MP0000767_abnormal_smooth_muscle1.10726012
78* MP0001819_abnormal_immune_cell1.09880437
79MP0001501_abnormal_sleep_pattern1.09456573
80MP0003828_pulmonary_edema1.09287631
81* MP0002113_abnormal_skeleton_development1.07734991
82MP0002115_abnormal_skeleton_extremities1.07576820
83* MP0005166_decreased_susceptibility_to1.06680083
84* MP0002420_abnormal_adaptive_immunity1.06628771
85MP0003195_calcinosis1.05503352
86* MP0010155_abnormal_intestine_physiology1.05383821
87MP0008469_abnormal_protein_level1.05348961
88* MP0009763_increased_sensitivity_to1.04388932
89MP0000163_abnormal_cartilage_morphology1.02349736
90* MP0009765_abnormal_xenobiotic_induced0.99986888
91* MP0005464_abnormal_platelet_physiology0.99160503
92MP0010307_abnormal_tumor_latency0.98890831
93MP0005310_abnormal_salivary_gland0.96845467
94MP0005397_hematopoietic_system_phenotyp0.95821716
95MP0001545_abnormal_hematopoietic_system0.95821716
96MP0005671_abnormal_response_to0.94660692
97MP0000604_amyloidosis0.94022537
98* MP0002398_abnormal_bone_marrow0.93347242
99MP0008260_abnormal_autophagy0.91175103
100* MP0008004_abnormal_stomach_pH0.87629854
101MP0004134_abnormal_chest_morphology0.86847112
102MP0009250_abnormal_appendicular_skeleto0.86522667
103MP0009333_abnormal_splenocyte_physiolog0.84540760
104* MP0000249_abnormal_blood_vessel0.84117720
105* MP0002429_abnormal_blood_cell0.84071385
106MP0004808_abnormal_hematopoietic_stem0.81412704
107MP0000465_gastrointestinal_hemorrhage0.78742813
108MP0005197_abnormal_uvea_morphology0.74898241
109MP0004782_abnormal_surfactant_physiolog0.74684404
110* MP0002168_other_aberrant_phenotype0.73172692
111MP0001851_eye_inflammation0.73087289
112MP0000920_abnormal_myelination0.72876094
113* MP0002722_abnormal_immune_system0.72685328
114MP0000627_abnormal_mammary_gland0.72038671
115MP0005388_respiratory_system_phenotype0.71603203
116MP0002133_abnormal_respiratory_system0.71603203
117MP0004883_abnormal_blood_vessel0.70902994
118MP0010368_abnormal_lymphatic_system0.69601097
119* MP0001216_abnormal_epidermal_layer0.69318659
120MP0005165_increased_susceptibility_to0.69105773
121* MP0000689_abnormal_spleen_morphology0.68115037
122MP0003763_abnormal_thymus_physiology0.67984568
123MP0002138_abnormal_hepatobiliary_system0.67437086
124MP0005595_abnormal_vascular_smooth0.67365546
125* MP0005535_abnormal_body_temperature0.66965243
126MP0003806_abnormal_nucleotide_metabolis0.66832145
127* MP0001614_abnormal_blood_vessel0.65324702
128MP0002128_abnormal_blood_circulation0.63991618
129MP0003221_abnormal_cardiomyocyte_apopto0.62972043
130* MP0001663_abnormal_digestive_system0.62967941
131MP0003950_abnormal_plasma_membrane0.60436208
132MP0003646_muscle_fatigue0.59993256
133* MP0008874_decreased_physiological_sensi0.57914310

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.39562116
2Abnormality of glycolipid metabolism (HP:0010969)5.20666889
3Abnormality of liposaccharide metabolism (HP:0010968)5.20666889
4Abnormality of glycosphingolipid metabolism (HP:0004343)5.20666889
5Peritonitis (HP:0002586)4.77444208
6Keratoconjunctivitis sicca (HP:0001097)4.46130989
7Protrusio acetabuli (HP:0003179)4.36768348
8Cervical subluxation (HP:0003308)4.22637981
9Aortic dissection (HP:0002647)4.11721969
10Keratoconjunctivitis (HP:0001096)4.05573870
11Epiphyseal dysplasia (HP:0002656)4.00004622
12Aortic aneurysm (HP:0004942)3.56944340
13Gangrene (HP:0100758)3.53818893
14Increased density of long bones (HP:0006392)3.50265733
15Cupped ribs (HP:0000887)3.45468527
16Loss of speech (HP:0002371)3.43280816
17Vertebral compression fractures (HP:0002953)3.40955513
18Vacuolated lymphocytes (HP:0001922)3.36527006
19Dysostosis multiplex (HP:0000943)3.35894444
20Eczematoid dermatitis (HP:0000976)3.34425903
21Atrophic scars (HP:0001075)3.19709472
22Amyloidosis (HP:0011034)3.18754549
23Vasculitis (HP:0002633)3.18612854
24Papilledema (HP:0001085)3.10724788
25Gastrointestinal infarctions (HP:0005244)3.06971087
26Osteolytic defects of the hand bones (HP:0009699)3.05256806
27Osteolytic defects of the phalanges of the hand (HP:0009771)3.05256806
28Disinhibition (HP:0000734)3.04887151
29Systemic lupus erythematosus (HP:0002725)3.03119857
30Radial bowing (HP:0002986)3.02965296
31Pulmonary infiltrates (HP:0002113)3.01130535
32Hemoptysis (HP:0002105)3.01071457
33Dilatation of the ascending aorta (HP:0005111)2.97702890
34Flat acetabular roof (HP:0003180)2.94903870
35Neonatal short-limb short stature (HP:0008921)2.94295551
36Increased cerebral lipofuscin (HP:0011813)2.90739243
37Hypoplastic ischia (HP:0003175)2.90209914
38Neurofibrillary tangles (HP:0002185)2.85184538
39Arterial thrombosis (HP:0004420)2.83883184
40Absent frontal sinuses (HP:0002688)2.83837441
41Recurrent abscess formation (HP:0002722)2.79933631
42Abnormality of mucopolysaccharide metabolism (HP:0011020)2.78258373
43Abnormality of polysaccharide metabolism (HP:0011012)2.78258373
44Abnormality of glycosaminoglycan metabolism (HP:0004371)2.78258373
45Short nail (HP:0001799)2.78122754
46Osteoarthritis (HP:0002758)2.73243744
47Vitreoretinal degeneration (HP:0000655)2.73150791
48Genu recurvatum (HP:0002816)2.70444898
49Hematochezia (HP:0002573)2.70380987
50Anorexia (HP:0002039)2.68094850
51Episodic fever (HP:0001954)2.63132542
52Shallow orbits (HP:0000586)2.62759697
53Fused cervical vertebrae (HP:0002949)2.62036627
54Urinary glycosaminoglycan excretion (HP:0003541)2.61581244
55Mucopolysacchariduria (HP:0008155)2.61581244
56Nuclear cataract (HP:0100018)2.60466702
57Interstitial pulmonary disease (HP:0006530)2.60442138
58Recurrent gram-negative bacterial infections (HP:0005420)2.57994055
59Ulnar bowing (HP:0003031)2.57294933
60Coxa vara (HP:0002812)2.55805669
61Irregular epiphyses (HP:0010582)2.55169017
62Recurrent bacterial skin infections (HP:0005406)2.53640355
63Increased IgE level (HP:0003212)2.47852206
64Soft skin (HP:0000977)2.44100079
65Abnormality of the ischium (HP:0003174)2.43694338
66Abnormality of the pleura (HP:0002103)2.41956191
67Orchitis (HP:0100796)2.41628792
68Increased IgM level (HP:0003496)2.40245474
69Wormian bones (HP:0002645)2.40053211
70Elevated erythrocyte sedimentation rate (HP:0003565)2.39398731
71Myocardial infarction (HP:0001658)2.39026249
72Urticaria (HP:0001025)2.38037650
73Abnormality of the pericardium (HP:0001697)2.37469765
74Increased serum ferritin (HP:0003281)2.37247263
75Recurrent skin infections (HP:0001581)2.36508645
76Small epiphyses (HP:0010585)2.35281859
77Cerebral aneurysm (HP:0004944)2.33238021
78Parakeratosis (HP:0001036)2.32520124
79Fragile skin (HP:0001030)2.31852672
80Abnormality of the vertebral endplates (HP:0005106)2.31686711
81Polyneuropathy (HP:0001271)2.31639668
82Tibial bowing (HP:0002982)2.31563291
83Metaphyseal cupping (HP:0003021)2.31025593
84Autoimmune hemolytic anemia (HP:0001890)2.30366641
85Spinal cord compression (HP:0002176)2.29650281
86Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.29290892
87Gingivitis (HP:0000230)2.28775676
88Mitral valve prolapse (HP:0001634)2.28705588
89Mesomelia (HP:0003027)2.28086911
90Beaking of vertebral bodies (HP:0004568)2.27731394
91Stomatitis (HP:0010280)2.26306881
92Abnormality of the proximal phalanges of the hand (HP:0009834)2.25827461
93Tetraparesis (HP:0002273)2.25790811
94Bowed forearm bones (HP:0003956)2.25676629
95Bowing of the arm (HP:0006488)2.25676629
96Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.23042204
97Recurrent fungal infections (HP:0002841)2.22979734
98Glomerulopathy (HP:0100820)2.22341741
99Flat capital femoral epiphysis (HP:0003370)2.21257173
100Apathy (HP:0000741)2.21048752
101Spinal cord lesions (HP:0100561)2.20733594
102Syringomyelia (HP:0003396)2.20733594
103Encephalitis (HP:0002383)2.20455176
104Thin bony cortex (HP:0002753)2.20423201
105Vertigo (HP:0002321)2.20415612
106Leukocytosis (HP:0001974)2.19776689
107Abnormality of the acetabulum (HP:0003170)2.18655296
108Hypergammaglobulinemia (HP:0010702)2.18624495
109Keratitis (HP:0000491)2.18164696
110Abnormality of the endocardium (HP:0004306)2.18119372
111Increased neuronal autofluorescent lipopigment (HP:0002074)2.16497174
112Myositis (HP:0100614)2.16218004
113Platyspondyly (HP:0000926)2.15099674
114Obstructive lung disease (HP:0006536)2.14401631
115Chronic obstructive pulmonary disease (HP:0006510)2.14401631
116Mediastinal lymphadenopathy (HP:0100721)2.14349575
117Joint swelling (HP:0001386)2.12672981
118Overgrowth (HP:0001548)2.12638983
119T lymphocytopenia (HP:0005403)2.12351849
120Mutism (HP:0002300)2.12306565
121Blue sclerae (HP:0000592)2.10815161
122Ectopia lentis (HP:0001083)2.10417154
123Diminished motivation (HP:0000745)2.09944539
124Abnormality of macrophages (HP:0004311)2.09879313
125Recurrent viral infections (HP:0004429)2.09819434
126Acne (HP:0001061)2.08692483
127Abnormal vertebral ossification (HP:0100569)2.08322975
128Pulmonary embolism (HP:0002204)2.08038595
129Abnormality of the peritoneum (HP:0002585)2.06198851
130Abnormal foot bone ossification (HP:0010675)2.05855699
131Meningitis (HP:0001287)2.05467385
132Broad face (HP:0000283)2.05208367
133Abnormality of proline metabolism (HP:0010907)2.02817170
134Hydroxyprolinuria (HP:0003080)2.02817170
135Abnormality of T cell number (HP:0011839)2.02552021
136Flattened epiphyses (HP:0003071)2.01845747
137Cerebral inclusion bodies (HP:0100314)2.01205950
138Broad ribs (HP:0000885)2.01052429
139Optic neuritis (HP:0100653)2.00921039
140Retrobulbar optic neuritis (HP:0100654)2.00921039
141Axonal loss (HP:0003447)2.00441712
142Abnormality of the nasal septum (HP:0000419)2.00208056
143Limited elbow extension (HP:0001377)2.00193621
144Glomerulonephritis (HP:0000099)1.98703547
145Persistence of primary teeth (HP:0006335)1.98118408
146Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.97556168
147Abnormality of the odontoid process (HP:0003310)1.97249669
148Joint stiffness (HP:0001387)1.97102531
149Thoracolumbar scoliosis (HP:0002944)1.96709927
150Autoimmune thrombocytopenia (HP:0001973)1.96525466
151Abnormality of the calcaneus (HP:0008364)1.95839907
152Progressive neurologic deterioration (HP:0002344)1.92849193
153Abnormality of the frontal sinuses (HP:0002687)1.91986353
154Segmental peripheral demyelination/remyelination (HP:0003481)1.90657833
155Hypoplasia of the odontoid process (HP:0003311)1.88755401
156Aseptic necrosis (HP:0010885)1.88680902
157Spondylolisthesis (HP:0003302)1.88149685
158Ankle contracture (HP:0006466)1.87906908
159Ovoid vertebral bodies (HP:0003300)1.87741673
160Nausea (HP:0002018)1.87591444
161Biconcave vertebral bodies (HP:0004586)1.87367014
162Abnormality of the lumbar spine (HP:0100712)1.86432802
163Arthralgia (HP:0002829)1.86392925
164Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.85576111
165Basal ganglia calcification (HP:0002135)1.85151207
166Thick nail (HP:0001805)1.84823266
167Abnormal tarsal ossification (HP:0008369)1.84533817
168Abnormal ossification of hand bones (HP:0005921)1.83774997
169Chest pain (HP:0100749)1.83379073
170Abnormality of carpal bone ossification (HP:0006257)1.82218286
171Abnormality of the vasculature of the conjunctiva (HP:0008054)1.81876922
172Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.81553558
173Vertebral hypoplasia (HP:0008417)1.81553558
174Increased connective tissue (HP:0009025)1.81325672
175Abnormality of iron homeostasis (HP:0011031)1.81039804
176Amaurosis fugax (HP:0100576)1.80745091
177Asymmetric septal hypertrophy (HP:0001670)1.80255243
178Metaphyseal irregularity (HP:0003025)1.78119815
179Alveolar cell carcinoma (HP:0006519)1.76643476
180Neuronal loss in central nervous system (HP:0002529)1.76624519
181Malnutrition (HP:0004395)1.72865292
182Neoplasm of the tracheobronchial system (HP:0100552)1.72168561

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR23.83670631
2MAP3K143.61789688
3TTN3.34263019
4TBK13.09546268
5ERN12.89770226
6PBK2.88724238
7PIM22.56625143
8PRPF4B2.49225585
9BMPR22.45416717
10GRK72.45152845
11IRAK32.33752345
12MAP3K32.29670531
13EPHA22.11631167
14IRAK12.09246368
15IRAK22.03164836
16IKBKB2.01880579
17RPS6KA41.95540386
18RIPK41.79567213
19BMX1.79097640
20TESK11.76751976
21TYK21.73374498
22MAP4K11.73157536
23IKBKE1.69363360
24JAK31.68741721
25TRIB31.67904158
26PAK21.58420881
27BLK1.56738264
28CSK1.52836501
29EPHB11.48097992
30PIK3CG1.47705994
31CDC42BPA1.46468330
32MYLK1.46051883
33TRPM71.43983401
34JAK11.43674805
35MAP3K131.41803975
36CHUK1.38315779
37LATS11.37311086
38EPHA31.34548548
39MAP3K11.34326619
40STK31.30339020
41LRRK21.29424422
42PDGFRA1.27152918
43STK101.25359544
44ERBB31.23422862
45MOS1.23285967
46TAOK31.14375202
47ABL21.14000185
48IRAK41.08443532
49PLK21.08054985
50FGR1.06291563
51DMPK1.05126071
52PAK31.04900995
53KIT1.03683302
54LIMK11.02430236
55PTK21.01951966
56PIM10.98066667
57ERBB40.97283740
58RIPK10.96493961
59PRKG20.92313005
60EPHB20.92303905
61NEK90.91381052
62ARAF0.90003152
63PKN20.86444284
64MAP3K50.85042071
65FER0.84864116
66HCK0.83906430
67PTK60.82706297
68ADRBK20.82643234
69NUAK10.82236619
70LATS20.80449592
71PIK3CA0.78815563
72SIK30.74791129
73NME20.72827149
74FGFR30.72450980
75PDGFRB0.72013864
76MARK30.71051665
77MST1R0.70857555
78EGFR0.69719678
79MAP2K30.68891621
80ABL10.67578274
81CLK10.67283285
82SYK0.65030992
83INSR0.65013877
84MATK0.64926056
85MST40.64345586
86* LYN0.63239681
87MAP2K10.60508310
88PTK2B0.60366489
89MET0.57729345
90FGFR40.56456179
91TAOK10.56300642
92TAOK20.56119131
93RAF10.55570077
94PAK40.54798112
95STK38L0.54600041
96DAPK30.53861192
97DYRK30.53168427
98GSK3A0.52925009
99ZAP700.51109713
100CDK60.50939582
101TYRO30.50644907
102MAPK70.49357008
103TXK0.49154033
104MAPK40.47325804
105HIPK20.47138169
106CSF1R0.45357999
107MAPKAPK20.45043542
108FGFR10.44712814
109FRK0.44350333
110BTK0.43786755
111STK240.43022551
112ROCK10.43019160
113JAK20.42016531
114ACVR1B0.41899265
115PAK10.40949526
116LCK0.40262586
117TGFBR20.40244804
118KSR20.40172739
119EIF2AK20.39670840
120SIK10.38923303
121MELK0.38718480
122MAP3K110.38694691
123RPS6KC10.35127866
124RPS6KL10.35127866
125MAP2K60.34026657
126KSR10.33969543
127FES0.33587800
128DAPK20.32384179
129PDPK10.31717798
130PDK10.29746932
131AKT30.29365573
132MAP3K60.27514701
133MARK20.27084844
134RPS6KA60.26428974
135MAP3K90.26057028
136RPS6KA20.22013239
137PKN10.21951590
138MAP3K20.20832395
139TEC0.20677449
140PRKAA20.20275122
141RPS6KA10.20011503

Predicted pathways (KEGG)

RankGene SetZ-score
1Malaria_Homo sapiens_hsa051443.10806151
2* Leishmaniasis_Homo sapiens_hsa051402.92240525
3Graft-versus-host disease_Homo sapiens_hsa053322.73498914
4Legionellosis_Homo sapiens_hsa051342.56190666
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.42263925
6* TNF signaling pathway_Homo sapiens_hsa046682.38612201
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.30590267
8Pertussis_Homo sapiens_hsa051332.24520325
9Rheumatoid arthritis_Homo sapiens_hsa053232.22703147
10ECM-receptor interaction_Homo sapiens_hsa045122.17933375
11* NF-kappa B signaling pathway_Homo sapiens_hsa040642.11906093
12Salmonella infection_Homo sapiens_hsa051322.04759981
13Osteoclast differentiation_Homo sapiens_hsa043802.00656906
14Tuberculosis_Homo sapiens_hsa051521.84059656
15Amoebiasis_Homo sapiens_hsa051461.83940293
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82804465
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.81742357
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.76292412
19Shigellosis_Homo sapiens_hsa051311.73759610
20Other glycan degradation_Homo sapiens_hsa005111.73210428
21Toxoplasmosis_Homo sapiens_hsa051451.62351852
22Staphylococcus aureus infection_Homo sapiens_hsa051501.61001216
23Allograft rejection_Homo sapiens_hsa053301.60813880
24Phagosome_Homo sapiens_hsa041451.60088237
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59145137
26Type I diabetes mellitus_Homo sapiens_hsa049401.58871735
27African trypanosomiasis_Homo sapiens_hsa051431.57537744
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.57481327
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.57407568
30Focal adhesion_Homo sapiens_hsa045101.56047125
31Measles_Homo sapiens_hsa051621.50654511
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.47345868
33Proteoglycans in cancer_Homo sapiens_hsa052051.47284338
34Hematopoietic cell lineage_Homo sapiens_hsa046401.43967070
35Influenza A_Homo sapiens_hsa051641.43316097
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34428672
37Apoptosis_Homo sapiens_hsa042101.31852793
38* Small cell lung cancer_Homo sapiens_hsa052221.21719591
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.21706109
40Asthma_Homo sapiens_hsa053101.19595489
41Bladder cancer_Homo sapiens_hsa052191.17025143
42Hepatitis B_Homo sapiens_hsa051611.15143701
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.08484322
44Chemokine signaling pathway_Homo sapiens_hsa040621.04614164
45Chronic myeloid leukemia_Homo sapiens_hsa052201.04081731
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.03811405
47Antigen processing and presentation_Homo sapiens_hsa046121.02983826
48TGF-beta signaling pathway_Homo sapiens_hsa043501.01575295
49Herpes simplex infection_Homo sapiens_hsa051680.97603266
50Lysosome_Homo sapiens_hsa041420.94862968
51* MicroRNAs in cancer_Homo sapiens_hsa052060.94343503
52Viral myocarditis_Homo sapiens_hsa054160.92943523
53B cell receptor signaling pathway_Homo sapiens_hsa046620.92393786
54Prion diseases_Homo sapiens_hsa050200.91805385
55Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88818792
56HIF-1 signaling pathway_Homo sapiens_hsa040660.88010076
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87920194
58Protein digestion and absorption_Homo sapiens_hsa049740.85657101
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.82747492
60Hepatitis C_Homo sapiens_hsa051600.82245041
61Adherens junction_Homo sapiens_hsa045200.81419448
62p53 signaling pathway_Homo sapiens_hsa041150.81286509
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81202683
64Platelet activation_Homo sapiens_hsa046110.80268428
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.78514061
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78380050
67Pancreatic cancer_Homo sapiens_hsa052120.77755821
68PI3K-Akt signaling pathway_Homo sapiens_hsa041510.75772762
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.70230708
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69949422
71Type II diabetes mellitus_Homo sapiens_hsa049300.68456741
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64260576
73Dilated cardiomyopathy_Homo sapiens_hsa054140.62653484
74Viral carcinogenesis_Homo sapiens_hsa052030.61586730
75Acute myeloid leukemia_Homo sapiens_hsa052210.59581930
76HTLV-I infection_Homo sapiens_hsa051660.58212844
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57635124
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57009498
79Complement and coagulation cascades_Homo sapiens_hsa046100.56354174
80Mineral absorption_Homo sapiens_hsa049780.55858170
81Melanoma_Homo sapiens_hsa052180.55571615
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55311565
83Prolactin signaling pathway_Homo sapiens_hsa049170.53627137
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52659892
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50957338
86Sphingolipid metabolism_Homo sapiens_hsa006000.49452111
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.48145481
88Renal cell carcinoma_Homo sapiens_hsa052110.47197570
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46989260
90Autoimmune thyroid disease_Homo sapiens_hsa053200.46380999
91Rap1 signaling pathway_Homo sapiens_hsa040150.46294702
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46207448
93T cell receptor signaling pathway_Homo sapiens_hsa046600.45496810
94MAPK signaling pathway_Homo sapiens_hsa040100.45126040
95Epstein-Barr virus infection_Homo sapiens_hsa051690.42970873
96Prostate cancer_Homo sapiens_hsa052150.42453310
97Notch signaling pathway_Homo sapiens_hsa043300.41423485
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39326830
99Dorso-ventral axis formation_Homo sapiens_hsa043200.39116899
100* VEGF signaling pathway_Homo sapiens_hsa043700.38398936
101Glioma_Homo sapiens_hsa052140.38250455
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.37508814
103Hippo signaling pathway_Homo sapiens_hsa043900.34955773
104ErbB signaling pathway_Homo sapiens_hsa040120.34153779
105* Pathways in cancer_Homo sapiens_hsa052000.33360042
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.32920042
107GnRH signaling pathway_Homo sapiens_hsa049120.32865216
108FoxO signaling pathway_Homo sapiens_hsa040680.32126269
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31574664
110Insulin resistance_Homo sapiens_hsa049310.30913627
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27489324
112mTOR signaling pathway_Homo sapiens_hsa041500.24759054
113Endocytosis_Homo sapiens_hsa041440.24195884
114Primary immunodeficiency_Homo sapiens_hsa053400.24071955
115Fatty acid biosynthesis_Homo sapiens_hsa000610.22255010
116Non-small cell lung cancer_Homo sapiens_hsa052230.21620131
117Galactose metabolism_Homo sapiens_hsa000520.21513989
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.16138265
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16097625

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