PTGIS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)5.60106246
2regulation of apoptotic cell clearance (GO:2000425)5.51179568
3regulation of integrin activation (GO:0033623)5.19173750
4collagen fibril organization (GO:0030199)4.99414218
5type B pancreatic cell proliferation (GO:0044342)4.94907879
6kidney mesenchyme development (GO:0072074)4.79187084
7apoptotic cell clearance (GO:0043277)4.73744056
8sequestering of extracellular ligand from receptor (GO:0035581)4.71984522
9cell migration involved in heart development (GO:0060973)4.56974173
10keratan sulfate catabolic process (GO:0042340)4.54968434
11mesenchymal-epithelial cell signaling (GO:0060638)4.46525192
12axon extension involved in axon guidance (GO:0048846)4.31223641
13neuron projection extension involved in neuron projection guidance (GO:1902284)4.31223641
14bone trabecula formation (GO:0060346)4.20772079
15negative regulation of chondrocyte differentiation (GO:0032331)4.11051436
16paraxial mesoderm development (GO:0048339)4.05302516
17smooth muscle tissue development (GO:0048745)4.01081241
18endothelial cell chemotaxis (GO:0035767)4.00810797
19pericardium development (GO:0060039)3.93069691
20complement activation, alternative pathway (GO:0006957)3.91772489
21basement membrane organization (GO:0071711)3.80363077
22endothelial cell morphogenesis (GO:0001886)3.76988044
23positive regulation of gastrulation (GO:2000543)3.76436614
24regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.73119340
25cell proliferation involved in metanephros development (GO:0072203)3.72196042
26middle ear morphogenesis (GO:0042474)3.68363345
27extracellular fibril organization (GO:0043206)3.68344912
28mannose metabolic process (GO:0006013)3.67775469
29chondrocyte proliferation (GO:0035988)3.65149239
30endodermal cell differentiation (GO:0035987)3.65050378
31regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.61923934
32lymph vessel development (GO:0001945)3.59030847
33regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.58800295
34blood vessel maturation (GO:0001955)3.57367487
35positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.47111174
36tooth mineralization (GO:0034505)3.44910578
37virion attachment to host cell (GO:0019062)3.43572210
38adhesion of symbiont to host cell (GO:0044650)3.43572210
39regulation of SMAD protein import into nucleus (GO:0060390)3.41547296
40skin morphogenesis (GO:0043589)3.40902279
41endothelial tube morphogenesis (GO:0061154)3.38795557
42morphogenesis of an endothelium (GO:0003159)3.38795557
43cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.38522768
44regulation of endothelial cell differentiation (GO:0045601)3.37383697
45regulation of G0 to G1 transition (GO:0070316)3.36681482
46negative regulation of cartilage development (GO:0061037)3.29121051
47outer ear morphogenesis (GO:0042473)3.26686756
48collagen metabolic process (GO:0032963)3.26417414
49regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.22098640
50negative regulation of BMP signaling pathway (GO:0030514)3.19698817
51wound healing, spreading of epidermal cells (GO:0035313)3.17471274
52lung-associated mesenchyme development (GO:0060484)3.15905470
53collagen catabolic process (GO:0030574)3.15560772
54cardiac myofibril assembly (GO:0055003)3.14688705
55regulation of cardioblast differentiation (GO:0051890)3.13592214
56negative regulation of smooth muscle cell migration (GO:0014912)3.12194815
57fibril organization (GO:0097435)3.11890785
58dermatan sulfate biosynthetic process (GO:0030208)3.11352448
59ventricular cardiac muscle cell development (GO:0055015)3.11198535
60embryonic cranial skeleton morphogenesis (GO:0048701)3.08447350
61multicellular organismal macromolecule metabolic process (GO:0044259)3.07787293
62lipoxygenase pathway (GO:0019372)3.06512319
63positive regulation of endothelial cell differentiation (GO:0045603)3.04909611
64endocardial cushion development (GO:0003197)3.04790172
65positive regulation of mesenchymal cell proliferation (GO:0002053)3.04033330
66positive regulation of SMAD protein import into nucleus (GO:0060391)3.03989721
67negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.01359324
68opsonization (GO:0008228)3.01087983
69regulation of integrin-mediated signaling pathway (GO:2001044)3.00568885
70cell migration involved in sprouting angiogenesis (GO:0002042)2.99402384
71cell differentiation involved in metanephros development (GO:0072202)2.99005637
72positive regulation of cardiac muscle cell proliferation (GO:0060045)2.97495038
73peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.97294132
74peptidyl-proline hydroxylation (GO:0019511)2.95930773
75regulation of gastrulation (GO:0010470)2.95735303
76glomerular basement membrane development (GO:0032836)2.94999926
77regulation of chondrocyte differentiation (GO:0032330)2.93061489
78regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.92159766
79maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.91424496
80mesenchymal cell differentiation involved in kidney development (GO:0072161)2.91270316
81mesenchymal cell differentiation involved in renal system development (GO:2001012)2.91270316
82cardiac epithelial to mesenchymal transition (GO:0060317)2.90214862
83multicellular organismal catabolic process (GO:0044243)2.90056897
84multicellular organismal metabolic process (GO:0044236)2.89513378
85negative chemotaxis (GO:0050919)2.88902571
86organ induction (GO:0001759)2.87355460
87cell proliferation involved in kidney development (GO:0072111)2.86218622
88positive regulation of osteoblast proliferation (GO:0033690)2.86168518
89positive regulation of cardiac muscle tissue development (GO:0055025)2.85970010
90protein retention in ER lumen (GO:0006621)2.84314221
91inner ear receptor cell development (GO:0060119)2.82199723
92regulation of organ formation (GO:0003156)2.82043266
93venous blood vessel morphogenesis (GO:0048845)2.81886107
94regulation of complement activation (GO:0030449)2.81833644
95regulation of transforming growth factor beta2 production (GO:0032909)2.81741090
96regulation of non-canonical Wnt signaling pathway (GO:2000050)2.80810123
97ventricular septum development (GO:0003281)2.80536104
98negative regulation of cardiac muscle tissue growth (GO:0055022)2.79931331
99negative regulation of heart growth (GO:0061117)2.79931331
100regulation of chemokine-mediated signaling pathway (GO:0070099)2.79484348
101vasculature development (GO:0001944)2.79042828
102regulation of mesenchymal cell proliferation (GO:0010464)2.78287237
103dermatan sulfate metabolic process (GO:0030205)2.78122801
104trabecula formation (GO:0060343)2.77982713
105plasma membrane repair (GO:0001778)2.76693828
106lymphangiogenesis (GO:0001946)2.76174406
107chondroitin sulfate catabolic process (GO:0030207)2.74830115
108lung morphogenesis (GO:0060425)2.72873081
109mesonephros development (GO:0001823)2.71909943
110protein hydroxylation (GO:0018126)2.71368803
111retina vasculature morphogenesis in camera-type eye (GO:0061299)2.71158775
112regulation of cardiac muscle tissue development (GO:0055024)2.71108116
113regulation of endothelial cell chemotaxis (GO:2001026)2.71006579
114regulation of cardiac muscle cell differentiation (GO:2000725)2.70727286
115head development (GO:0060322)2.70546828
116extracellular matrix disassembly (GO:0022617)2.70498030
117ribosome assembly (GO:0042255)2.69894142
118chondrocyte development (GO:0002063)2.68982005
119regulation of plasminogen activation (GO:0010755)2.68296498
120notochord development (GO:0030903)2.67446410
121adhesion of symbiont to host (GO:0044406)2.67019582
122cell adhesion mediated by integrin (GO:0033627)2.65835788
123positive regulation of epithelial to mesenchymal transition (GO:0010718)2.65751722
124regulation of cartilage development (GO:0061035)2.65227613
125regulation of mitotic spindle organization (GO:0060236)2.63758989
126negative regulation of androgen receptor signaling pathway (GO:0060766)2.63378523
127extracellular matrix assembly (GO:0085029)2.63116410
128negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.62634336
129response to gravity (GO:0009629)2.62527767
130extracellular negative regulation of signal transduction (GO:1900116)2.61195409
131extracellular regulation of signal transduction (GO:1900115)2.61195409
132positive regulation of cell adhesion mediated by integrin (GO:0033630)2.60600230
133extracellular matrix organization (GO:0030198)2.60304970
134extracellular structure organization (GO:0043062)2.59855753
135positive regulation of cardiac muscle tissue growth (GO:0055023)2.57338853
136artery development (GO:0060840)2.55590172
137regulation of cardiac muscle tissue growth (GO:0055021)2.54658202
138blood vessel remodeling (GO:0001974)2.54012255
139substrate adhesion-dependent cell spreading (GO:0034446)2.51814711
140chronic inflammatory response (GO:0002544)2.51705133
141regulation of gene silencing by RNA (GO:0060966)2.50697198
142regulation of posttranscriptional gene silencing (GO:0060147)2.50697198
143regulation of gene silencing by miRNA (GO:0060964)2.50697198
144regulation of spindle organization (GO:0090224)2.49678677
145lung vasculature development (GO:0060426)2.47830726
146epithelial cell-cell adhesion (GO:0090136)2.47264529
147vascular endothelial growth factor signaling pathway (GO:0038084)2.45188251
148formation of translation preinitiation complex (GO:0001731)2.43922133
149* regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.43624437
150nucleobase biosynthetic process (GO:0046112)2.43262746
151mesenchyme development (GO:0060485)2.43092425
152regulation of tight junction assembly (GO:2000810)2.41870423
153metanephric mesenchyme development (GO:0072075)2.40905424
154nucleotide-sugar biosynthetic process (GO:0009226)2.40529001
155regulation of protein activation cascade (GO:2000257)2.39582833

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.77974288
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.68157410
3E2F7_22180533_ChIP-Seq_HELA_Human3.82649455
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.51788100
5CLOCK_20551151_ChIP-Seq_293T_Human3.07366403
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.00434072
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.59982640
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.59095671
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.49399000
10* EED_16625203_ChIP-ChIP_MESCs_Mouse2.48431524
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45940080
12* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.43150765
13* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.40524427
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.40413784
15GBX2_23144817_ChIP-Seq_PC3_Human2.38742061
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.33043100
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.24358395
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.23160298
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.22161250
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.21084412
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.19125768
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.15808902
23* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14993008
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06558883
25HIF1A_21447827_ChIP-Seq_MCF-7_Human2.01178972
26AR_21909140_ChIP-Seq_LNCAP_Human2.00004626
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.99500995
28* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.98530805
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.97065141
30TCF3_18692474_ChIP-Seq_MEFs_Mouse1.95139328
31* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.94727384
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94302156
33EZH2_22144423_ChIP-Seq_EOC_Human1.93775797
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.90951304
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.90951304
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.90196090
37* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86446559
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.86168414
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83341517
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.83328055
41* PIAS1_25552417_ChIP-Seq_VCAP_Human1.82757445
42ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.78792900
43WT1_19549856_ChIP-ChIP_CCG9911_Human1.77908732
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.77324025
45TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76403049
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.74521557
47NRF2_20460467_ChIP-Seq_MEFs_Mouse1.74521557
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.73550811
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.68348784
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68056294
51ATF3_27146783_Chip-Seq_COLON_Human1.67151549
52TP53_16413492_ChIP-PET_HCT116_Human1.66450486
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65966484
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65866071
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65707700
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.65330394
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61719627
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61135967
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.56360023
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.55500550
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55070601
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.53905377
63KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.53905377
64KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.53905377
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.48642757
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47713070
67NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.47554310
68CJUN_26792858_Chip-Seq_BT549_Human1.47399334
69HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.45827119
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44564263
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.44125945
72MTF2_20144788_ChIP-Seq_MESCs_Mouse1.43528080
73* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42657193
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42393523
75JARID2_20064375_ChIP-Seq_MESCs_Mouse1.42162768
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.42034281
77TP53_18474530_ChIP-ChIP_U2OS_Human1.41805001
78XRN2_22483619_ChIP-Seq_HELA_Human1.41465514
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41389149
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41213633
81CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.40491852
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.40416818
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39959982
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39237810
85TBX3_20139965_ChIP-Seq_ESCs_Mouse1.37607386
86* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.37512233
87NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37364361
88ELK1_22589737_ChIP-Seq_MCF10A_Human1.37267671
89TBX3_20139965_ChIP-Seq_MESCs_Mouse1.37027078
90RACK7_27058665_Chip-Seq_MCF-7_Human1.35378153
91EST1_17652178_ChIP-ChIP_JURKAT_Human1.35063663
92* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34054629
93SMAD4_21799915_ChIP-Seq_A2780_Human1.33510654
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33028835
95TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.31918411
96BRD4_25478319_ChIP-Seq_HGPS_Human1.31838015
97P300_19829295_ChIP-Seq_ESCs_Human1.31796593
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.31638308
99TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31181671
100KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.30610561
101SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29891558
102E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29869431
103SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29532218
104BCAT_22108803_ChIP-Seq_LS180_Human1.29376131
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28976615
106VDR_22108803_ChIP-Seq_LS180_Human1.28306995
107MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.28245644
108JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.28112567
109* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27705231
110ISL1_27105846_Chip-Seq_CPCs_Mouse1.27339782
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27091442
112FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27043057
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25916951
114NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25110091
115SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.23610663
116UBF1/2_26484160_Chip-Seq_HMECs_Human1.23204596
117* EZH2_27294783_Chip-Seq_ESCs_Mouse1.22765379
118TP53_20018659_ChIP-ChIP_R1E_Mouse1.22545208
119CBX2_27304074_Chip-Seq_ESCs_Mouse1.21779875
120TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21321532
121AHR_22903824_ChIP-Seq_MCF-7_Human1.20465913
122KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20085344
123* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.20008006
124* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19702821
125GABP_17652178_ChIP-ChIP_JURKAT_Human1.18858344
126NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18664351
127SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18636937
128SALL1_21062744_ChIP-ChIP_HESCs_Human1.18347887
129RING1B_27294783_Chip-Seq_ESCs_Mouse1.17538518
130RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17268400
131TP53_22127205_ChIP-Seq_IMR90_Human1.15933503
132SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15789277
133EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.15461463
134ZNF274_21170338_ChIP-Seq_K562_Hela1.15417096
135SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14235788
136* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.13789249
137SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12951045
138SA1_22415368_ChIP-Seq_MEFs_Mouse1.12302581
139SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12231976
140SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12231976
141KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10459111
142SMC1_22415368_ChIP-Seq_MEFs_Mouse1.10260060
143EZH2_27294783_Chip-Seq_NPCs_Mouse1.09801455
144BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09560655
145ESR2_21235772_ChIP-Seq_MCF-7_Human1.09337662
146ARNT_22903824_ChIP-Seq_MCF-7_Human1.09304986
147TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09011446
148SMC3_22415368_ChIP-Seq_MEFs_Mouse1.07659661
149EP300_21415370_ChIP-Seq_HL-1_Mouse1.07361629
150PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07206738
151JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07011688
152ZNF263_19887448_ChIP-Seq_K562_Human1.06520904
153BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06496274
154KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06380385
155CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06200853
156PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04510690
157SMAD3_21741376_ChIP-Seq_EPCs_Human1.04290660
158OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04024100
159FUS_26573619_Chip-Seq_HEK293_Human1.03748847
160* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03662125
161KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03559777
162CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03370241
163KDM2B_26808549_Chip-Seq_REH_Human1.03275362
164SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03153602
165DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02370601
166P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01639918
167MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00918552
168BP1_19119308_ChIP-ChIP_Hs578T_Human1.00307061
169SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99480324
170ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98903278
171TBX20_22080862_ChIP-Seq_HEART_Mouse0.98636595
172TBX20_22328084_ChIP-Seq_HEART_Mouse0.98636595
173JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98378878
174TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97839981
175CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96946748
176MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95128317
177NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94176184
178KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93817791
179* STAT3_23295773_ChIP-Seq_U87_Human0.91877982
180STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90748829
181MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90131401
182SMAD3_21741376_ChIP-Seq_HESCs_Human0.90117762
183WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88838444
184NFE2_27457419_Chip-Seq_LIVER_Mouse0.88228700

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.16954557
2MP0005503_abnormal_tendon_morphology5.08482987
3MP0005275_abnormal_skin_tensile4.00690007
4MP0003705_abnormal_hypodermis_morpholog3.32485514
5MP0010368_abnormal_lymphatic_system3.08514470
6MP0004272_abnormal_basement_membrane2.87719046
7MP0001958_emphysema2.86040286
8MP0003279_aneurysm2.81890246
9MP0001542_abnormal_bone_strength2.50433877
10MP0006054_spinal_hemorrhage2.39415382
11MP0003566_abnormal_cell_adhesion2.33602640
12MP0005508_abnormal_skeleton_morphology2.16334092
13MP0010030_abnormal_orbit_morphology2.11390653
14MP0005023_abnormal_wound_healing2.08154589
15MP0002254_reproductive_system_inflammat1.93318523
16MP0005623_abnormal_meninges_morphology1.91578902
17MP0002108_abnormal_muscle_morphology1.77809266
18MP0001879_abnormal_lymphatic_vessel1.77476328
19MP0000751_myopathy1.73129011
20MP0000750_abnormal_muscle_regeneration1.72125726
21MP0000767_abnormal_smooth_muscle1.69383163
22MP0004084_abnormal_cardiac_muscle1.58887652
23MP0010386_abnormal_urinary_bladder1.58024460
24MP0003123_paternal_imprinting1.53396556
25MP0002060_abnormal_skin_morphology1.52793680
26MP0005257_abnormal_intraocular_pressure1.51757345
27MP0002295_abnormal_pulmonary_circulatio1.51252118
28MP0001299_abnormal_eye_distance/1.49696844
29MP0005390_skeleton_phenotype1.47440591
30MP0002282_abnormal_trachea_morphology1.35895753
31MP0005171_absent_coat_pigmentation1.34874314
32MP0002933_joint_inflammation1.32570500
33MP0004185_abnormal_adipocyte_glucose1.28859991
34MP0009250_abnormal_appendicular_skeleto1.27049814
35MP0009384_cardiac_valve_regurgitation1.24772128
36MP0003567_abnormal_fetal_cardiomyocyte1.23248493
37MP0001533_abnormal_skeleton_physiology1.21525729
38MP0003091_abnormal_cell_migration1.20692792
39MP0010352_gastrointestinal_tract_polyps1.20484800
40MP0000163_abnormal_cartilage_morphology1.18368200
41MP0000733_abnormal_muscle_development1.17379042
42MP0000749_muscle_degeneration1.16472335
43MP0003693_abnormal_embryo_hatching1.15437095
44MP0000516_abnormal_urinary_system1.14994027
45MP0005367_renal/urinary_system_phenotyp1.14994027
46MP0004858_abnormal_nervous_system1.14990736
47MP0000343_altered_response_to1.14521863
48MP0002127_abnormal_cardiovascular_syste1.11127816
49MP0003950_abnormal_plasma_membrane1.09064174
50MP0002115_abnormal_skeleton_extremities1.08962608
51MP0002128_abnormal_blood_circulation1.04903045
52MP0002932_abnormal_joint_morphology1.04829209
53MP0002896_abnormal_bone_mineralization1.04762011
54MP0003115_abnormal_respiratory_system1.04340372
55MP0002249_abnormal_larynx_morphology1.03344691
56* MP0001614_abnormal_blood_vessel1.03136380
57MP0004957_abnormal_blastocyst_morpholog1.02862384
58MP0000049_abnormal_middle_ear1.02714927
59MP0003828_pulmonary_edema0.98733888
60MP0002113_abnormal_skeleton_development0.97664761
61MP0001915_intracranial_hemorrhage0.97361680
62MP0002233_abnormal_nose_morphology0.96734831
63MP0003937_abnormal_limbs/digits/tail_de0.96393393
64MP0002925_abnormal_cardiovascular_devel0.94963330
65MP0002938_white_spotting0.94839850
66MP0006138_congestive_heart_failure0.94750183
67MP0001175_abnormal_lung_morphology0.93314434
68MP0003448_altered_tumor_morphology0.93168950
69MP0000013_abnormal_adipose_tissue0.92392907
70MP0002998_abnormal_bone_remodeling0.92169622
71MP0005330_cardiomyopathy0.92078081
72MP0001544_abnormal_cardiovascular_syste0.91327694
73MP0005385_cardiovascular_system_phenoty0.91327694
74MP0001243_abnormal_dermal_layer0.90817916
75MP0005595_abnormal_vascular_smooth0.89476356
76MP0005369_muscle_phenotype0.88501073
77MP0002168_other_aberrant_phenotype0.88366633
78MP0000428_abnormal_craniofacial_morphol0.88165440
79MP0009780_abnormal_chondrocyte_physiolo0.87991267
80MP0003935_abnormal_craniofacial_develop0.87615412
81MP0003385_abnormal_body_wall0.87252916
82MP0005076_abnormal_cell_differentiation0.85824199
83MP0003111_abnormal_nucleus_morphology0.84335430
84MP0003942_abnormal_urinary_system0.84125600
85MP0002116_abnormal_craniofacial_bone0.83414239
86MP0001730_embryonic_growth_arrest0.83245453
87MP0008932_abnormal_embryonic_tissue0.83199273
88MP0003984_embryonic_growth_retardation0.82753692
89MP0005388_respiratory_system_phenotype0.81891393
90MP0002133_abnormal_respiratory_system0.81891393
91MP0003795_abnormal_bone_structure0.81532454
92MP0003724_increased_susceptibility_to0.81310734
93MP0004134_abnormal_chest_morphology0.81214925
94MP0005670_abnormal_white_adipose0.81199727
95MP0002088_abnormal_embryonic_growth/wei0.81183758
96MP0003283_abnormal_digestive_organ0.81166787
97MP0000462_abnormal_digestive_system0.80774634
98MP0004087_abnormal_muscle_fiber0.80652397
99MP0003755_abnormal_palate_morphology0.80241639
100MP0002109_abnormal_limb_morphology0.78608452
101MP0000266_abnormal_heart_morphology0.78239472
102MP0009053_abnormal_anal_canal0.78124659
103MP0009840_abnormal_foam_cell0.77520381
104MP0000432_abnormal_head_morphology0.77319282
105MP0002837_dystrophic_cardiac_calcinosis0.77138021
106MP0005380_embryogenesis_phenotype0.77074366
107MP0001672_abnormal_embryogenesis/_devel0.77074366
108MP0010630_abnormal_cardiac_muscle0.76466299
109MP0003646_muscle_fatigue0.76168769
110MP0003941_abnormal_skin_development0.75783178
111MP0002102_abnormal_ear_morphology0.75652137
112MP0000759_abnormal_skeletal_muscle0.72453138
113MP0003878_abnormal_ear_physiology0.71575096
114MP0005377_hearing/vestibular/ear_phenot0.71575096
115* MP0000249_abnormal_blood_vessel0.71373551
116MP0001348_abnormal_lacrimal_gland0.71110629
117MP0004036_abnormal_muscle_relaxation0.70998731
118MP0000534_abnormal_ureter_morphology0.70672897
119MP0002086_abnormal_extraembryonic_tissu0.70586711
120MP0008775_abnormal_heart_ventricle0.69644627
121MP0003718_maternal_effect0.69052413
122MP0005620_abnormal_muscle_contractility0.67737101
123MP0005197_abnormal_uvea_morphology0.67444265
124MP0001661_extended_life_span0.66004842
125MP0002114_abnormal_axial_skeleton0.62778937
126MP0000538_abnormal_urinary_bladder0.62730307
127MP0001177_atelectasis0.55358860
128* MP0000230_abnormal_systemic_arterial0.55353909
129MP0004133_heterotaxia0.55085574
130MP0004145_abnormal_muscle_electrophysio0.49538756
131MP0002697_abnormal_eye_size0.49532914
132MP0005164_abnormal_response_to0.48212859
133MP0000762_abnormal_tongue_morphology0.48068787
134MP0003938_abnormal_ear_development0.47575576
135MP0004233_abnormal_muscle_weight0.46931295
136MP0004215_abnormal_myocardial_fiber0.46165690
137MP0000467_abnormal_esophagus_morphology0.45156043

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.04672821
2Premature rupture of membranes (HP:0001788)6.39975551
3Shallow orbits (HP:0000586)4.80495567
4Cervical subluxation (HP:0003308)4.30591563
5Ankle contracture (HP:0006466)4.19169032
6Broad metatarsal (HP:0001783)4.12067911
7Systemic lupus erythematosus (HP:0002725)3.90598620
8Wrist flexion contracture (HP:0001239)3.89487635
9Cerebral aneurysm (HP:0004944)3.79583109
10Aortic dissection (HP:0002647)3.75781911
11Biconcave vertebral bodies (HP:0004586)3.50868424
12Soft skin (HP:0000977)3.45856927
13Vertebral compression fractures (HP:0002953)3.43976180
14Coronal craniosynostosis (HP:0004440)3.33047009
15Aortic regurgitation (HP:0001659)3.32173079
16Bowel diverticulosis (HP:0005222)3.21097020
17Spinal rigidity (HP:0003306)3.13824719
18Bladder diverticulum (HP:0000015)3.05344372
19Aortic aneurysm (HP:0004942)3.04730228
20Aortic valve stenosis (HP:0001650)3.01676314
21Broad ribs (HP:0000885)3.00392887
22Neonatal short-limb short stature (HP:0008921)2.96256391
23Wormian bones (HP:0002645)2.93076483
24Coxa vara (HP:0002812)2.91837163
25Increased connective tissue (HP:0009025)2.91492807
26Metaphyseal cupping (HP:0003021)2.84395958
27Abnormality of dentin (HP:0010299)2.81917918
28Short nail (HP:0001799)2.81494685
29Peritonitis (HP:0002586)2.81342576
30Type 1 muscle fiber predominance (HP:0003803)2.80079483
31Wide anterior fontanel (HP:0000260)2.76022794
32Pulmonary artery stenosis (HP:0004415)2.73943990
33Abnormality of complement system (HP:0005339)2.72704260
34Mesomelia (HP:0003027)2.68466519
35Abnormality of the acetabulum (HP:0003170)2.67364208
36Blue sclerae (HP:0000592)2.62073659
37Increased corneal curvature (HP:0100692)2.60797090
38Keratoconus (HP:0000563)2.60797090
39Genu recurvatum (HP:0002816)2.57990572
40Atrophic scars (HP:0001075)2.56025293
41Glomerulonephritis (HP:0000099)2.55761805
42Spondylolisthesis (HP:0003302)2.53140579
43Striae distensae (HP:0001065)2.51115450
44Patent foramen ovale (HP:0001655)2.50964640
45Round ear (HP:0100830)2.48388594
46Osteolytic defects of the phalanges of the hand (HP:0009771)2.43779417
47Osteolytic defects of the hand bones (HP:0009699)2.43779417
48Beaking of vertebral bodies (HP:0004568)2.43750115
49Mild short stature (HP:0003502)2.43649632
50Joint stiffness (HP:0001387)2.41484143
51Fragile skin (HP:0001030)2.40415674
52Bronchomalacia (HP:0002780)2.39511008
53Mitral valve prolapse (HP:0001634)2.39423309
54Abnormality of the fetal cardiovascular system (HP:0010948)2.38900616
55Abnormal umbilical cord blood vessels (HP:0011403)2.38900616
56Single umbilical artery (HP:0001195)2.38900616
57Fused cervical vertebrae (HP:0002949)2.38462331
58Abnormal delivery (HP:0001787)2.38167636
59Dilatation of the ascending aorta (HP:0005111)2.37970679
60Platyspondyly (HP:0000926)2.37328955
61Hypoventilation (HP:0002791)2.36152669
62Abnormality of the umbilical cord (HP:0010881)2.34978562
63Redundant skin (HP:0001582)2.32092672
64Muscle fiber splitting (HP:0003555)2.31483688
65Flat cornea (HP:0007720)2.29376505
66Complement deficiency (HP:0004431)2.27135966
67Carpal bone hypoplasia (HP:0001498)2.26417672
68Mitral regurgitation (HP:0001653)2.26082105
69Ovoid vertebral bodies (HP:0003300)2.25821448
70Infantile muscular hypotonia (HP:0008947)2.25704447
71Vascular tortuosity (HP:0004948)2.24810623
72Ectopia lentis (HP:0001083)2.23737654
73Follicular hyperkeratosis (HP:0007502)2.23688211
74Spinal cord compression (HP:0002176)2.22455006
75Epiphyseal dysplasia (HP:0002656)2.22347142
76Breech presentation (HP:0001623)2.21424574
77Narrow nasal bridge (HP:0000446)2.15713794
78Small epiphyses (HP:0010585)2.15286643
79Joint laxity (HP:0001388)2.15064528
80Abnormality of the calcaneus (HP:0008364)2.11772417
81Hip contracture (HP:0003273)2.09110650
82Short hallux (HP:0010109)2.07765672
83Bulbous nose (HP:0000414)2.07744252
84Broad long bones (HP:0005622)2.06649452
85Morphological abnormality of the middle ear (HP:0008609)2.06524399
86Persistence of primary teeth (HP:0006335)2.01299483
87Flared iliac wings (HP:0002869)1.98528217
88Aneurysm (HP:0002617)1.97628916
89Irregular epiphyses (HP:0010582)1.96614757
90Aplasia/Hypoplasia of the hallux (HP:0008362)1.94224137
91Osteoarthritis (HP:0002758)1.93207469
92Increased variability in muscle fiber diameter (HP:0003557)1.93201086
93Hyperextensible skin (HP:0000974)1.91486101
94Ulnar bowing (HP:0003031)1.90739600
95Elbow flexion contracture (HP:0002987)1.89567959
96Delayed cranial suture closure (HP:0000270)1.88818835
97Absent epiphyses (HP:0010577)1.88190699
98Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.88190699
99Gingival overgrowth (HP:0000212)1.87881478
100Enlarged penis (HP:0000040)1.87791415
101Ulnar deviation of the wrist (HP:0003049)1.87679193
102Tarsal synostosis (HP:0008368)1.87124577
103Trismus (HP:0000211)1.86733484
104Slender build (HP:0001533)1.86636086
105Hematochezia (HP:0002573)1.85444015
106Breast hypoplasia (HP:0003187)1.85315061
107Limited hip movement (HP:0008800)1.84969625
108Abnormality of the distal phalanges of the toes (HP:0010182)1.84056754
109Metaphyseal dysplasia (HP:0100255)1.82596128
110Delayed closure of the anterior fontanelle (HP:0001476)1.82462566
111Camptodactyly of toe (HP:0001836)1.82046218
112Abnormality of skeletal muscle fiber size (HP:0012084)1.81920469
113Difficulty climbing stairs (HP:0003551)1.80913259
114Nonimmune hydrops fetalis (HP:0001790)1.80562197
115Broad phalanx (HP:0006009)1.80547150
116Arterial tortuosity (HP:0005116)1.80486291
117Cupped ribs (HP:0000887)1.79998759
118Inguinal hernia (HP:0000023)1.79671419
119Mildly elevated creatine phosphokinase (HP:0008180)1.79549277
120Tibial bowing (HP:0002982)1.79319277
121Rectal prolapse (HP:0002035)1.78889831
122Synostosis involving bones of the lower limbs (HP:0009138)1.78484859
123Synostosis involving bones of the feet (HP:0009140)1.78484859
124Hypoplasia of the odontoid process (HP:0003311)1.77897659
125Overgrowth (HP:0001548)1.77236130
126Abnormal cartilage morphology (HP:0002763)1.77098581
127Flat acetabular roof (HP:0003180)1.76727918
128Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76058241
129Hypoplasia of the iris (HP:0007676)1.75940863
130Knee flexion contracture (HP:0006380)1.75573161
131Subacute progressive viral hepatitis (HP:0006572)1.74753435
132Slender long bone (HP:0003100)1.74726442
133Turricephaly (HP:0000262)1.71944227
134Protruding ear (HP:0000411)1.71413413
135Thin bony cortex (HP:0002753)1.70258617
136Abnormality of the middle phalanges of the toes (HP:0010183)1.70237292
137Deviation of the hallux (HP:0010051)1.69725705
138Mitral stenosis (HP:0001718)1.68890703
139Disproportionate tall stature (HP:0001519)1.68685287
140Natal tooth (HP:0000695)1.67692244
141Renovascular hypertension (HP:0100817)1.67249796
142Broad finger (HP:0001500)1.61788546
143Abnormality of the anterior chamber (HP:0000593)1.61427974

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R3.48656875
2TRIB33.28351817
3BUB13.17095601
4LATS23.09336824
5STK38L3.09132291
6TTN2.93090609
7EPHA22.74984605
8DDR22.71245038
9NME22.49058282
10ADRBK22.34783443
11EPHB22.23761087
12GRK12.21982054
13MET2.21209803
14ERN12.12125781
15TGFBR22.04262560
16RPS6KA42.00127128
17LATS11.99887331
18KIT1.92352931
19STK241.90733898
20BMX1.76483844
21PDGFRB1.74717220
22MYLK1.73854139
23CDC42BPA1.70831897
24PAK41.70280418
25TIE11.69924961
26WEE11.67980331
27PKN21.62928918
28ADRBK11.61390333
29EIF2AK11.58997836
30PIM21.53995013
31RIPK11.53500243
32NLK1.52888682
33PDGFRA1.52638209
34FRK1.49448809
35STK31.45792399
36NTRK11.45613294
37WNK11.43211360
38TGFBR11.40091975
39PLK41.37737396
40AKT31.37392574
41ILK1.35316323
42MAP3K31.31821851
43PAK21.30815411
44PIK3CG1.26234577
45PAK31.25132615
46GRK51.24670019
47WNK31.23286365
48KDR1.22633528
49PIK3CA1.18788947
50PDK21.17621638
51BMPR1B1.17276845
52LRRK21.14633085
53NEK21.12556852
54WNK41.11149185
55INSRR1.11101367
56FLT31.08747657
57NEK91.08283879
58MAP3K71.07967830
59DAPK31.07846551
60CAMK1D1.07404196
61MAPK71.07056191
62MAP2K31.05807906
63MOS1.02285743
64PRKCE0.98289039
65STK100.97247271
66DYRK20.95912982
67TTK0.93653020
68PLK30.92263909
69PINK10.91696554
70TSSK60.91125487
71RPS6KA20.89637934
72FER0.89018018
73PAK10.86687220
74DMPK0.86211420
75PDK30.86112380
76PDK40.86112380
77CASK0.84815155
78PTK2B0.84596983
79FGFR10.83562797
80PLK10.83243375
81ZAK0.81237604
82PTK20.80363562
83PTK60.79227639
84MAP3K110.77987213
85CAMK10.76359202
86TAF10.76303338
87MAP3K80.75417397
88NUAK10.73881297
89MARK30.70575693
90LIMK10.69146315
91FGFR20.67904138
92MELK0.67085453
93TESK10.67022368
94ROCK10.65303108
95CDK70.63635566
96MTOR0.63569529
97NEK10.62701919
98TNIK0.61504010
99AURKB0.61296855
100ABL20.59663971
101EIF2AK30.59586991
102ERBB40.59165935
103MARK10.56457926
104BRAF0.55031287
105OBSCN0.54885844
106STK380.54263982
107CAMK1G0.53943522
108CDK80.53888942
109PNCK0.53419883
110MAP3K60.52974702
111PLK20.52495828
112PIM10.51622613
113MKNK20.51402122
114CDK40.50867635
115TAOK10.50042553
116BRSK20.49942544
117ACVR1B0.49225748
118TYRO30.48595619
119MAP2K20.48484705
120AURKA0.46953720
121PRKCI0.45965489
122PRKG10.45192796
123MAP4K20.44537468
124SGK2230.42848061
125SGK4940.42848061
126PRKD20.42300548
127ARAF0.40969414
128PRKD10.39982695
129PRKCH0.38310934
130TLK10.37395718
131MARK20.37106439
132FGFR40.35685389
133EPHB10.35283561
134MAP2K10.35037404
135PRKCG0.35026528
136IRAK30.34387314
137PRKD30.34130067
138TRPM70.33364364
139ALK0.32720968
140ERBB30.31904024
141ROCK20.31837524
142GSK3A0.31798267
143HIPK20.31122598
144CAMK2A0.30879135
145DAPK20.29707751
146RPS6KL10.28381287
147RPS6KC10.28381287
148RPS6KA60.27578590
149AKT20.25134447
150MAPKAPK30.24677913
151SRPK10.24401435
152EPHA30.24233532

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.56151248
2Staphylococcus aureus infection_Homo sapiens_hsa051503.17470719
3Other glycan degradation_Homo sapiens_hsa005112.81097990
4Proteasome_Homo sapiens_hsa030502.45587620
5RNA polymerase_Homo sapiens_hsa030202.37289490
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.32093238
7Focal adhesion_Homo sapiens_hsa045102.30782178
8Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.28022386
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23636955
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.19064477
11Malaria_Homo sapiens_hsa051442.15321946
12Complement and coagulation cascades_Homo sapiens_hsa046102.05576864
13Ribosome_Homo sapiens_hsa030102.05282357
14TGF-beta signaling pathway_Homo sapiens_hsa043502.04793455
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.01818010
16RNA transport_Homo sapiens_hsa030131.88563196
17Dilated cardiomyopathy_Homo sapiens_hsa054141.81456876
18Vascular smooth muscle contraction_Homo sapiens_hsa042701.80222775
19Proteoglycans in cancer_Homo sapiens_hsa052051.77059893
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.74129186
21Protein digestion and absorption_Homo sapiens_hsa049741.70842373
22Cell cycle_Homo sapiens_hsa041101.65272428
23Amoebiasis_Homo sapiens_hsa051461.64557423
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.59388342
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.58971115
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.57169351
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.56884760
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.56829259
29Selenocompound metabolism_Homo sapiens_hsa004501.54498865
30Hippo signaling pathway_Homo sapiens_hsa043901.53437976
31Adherens junction_Homo sapiens_hsa045201.53370964
32Small cell lung cancer_Homo sapiens_hsa052221.46759968
33Axon guidance_Homo sapiens_hsa043601.40031840
34DNA replication_Homo sapiens_hsa030301.34044736
35Bladder cancer_Homo sapiens_hsa052191.31938290
36PI3K-Akt signaling pathway_Homo sapiens_hsa041511.31595404
37Spliceosome_Homo sapiens_hsa030401.27617549
38* Arachidonic acid metabolism_Homo sapiens_hsa005901.25929318
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25120923
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24108267
41Basal cell carcinoma_Homo sapiens_hsa052171.22800776
42Pertussis_Homo sapiens_hsa051331.20097458
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.17592524
44Pyrimidine metabolism_Homo sapiens_hsa002401.17265667
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15771781
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12509128
47Prion diseases_Homo sapiens_hsa050201.12359064
48p53 signaling pathway_Homo sapiens_hsa041151.12183344
49Melanogenesis_Homo sapiens_hsa049161.07945949
50MicroRNAs in cancer_Homo sapiens_hsa052061.03876806
51Hedgehog signaling pathway_Homo sapiens_hsa043401.02812888
52Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01645446
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00024202
54HIF-1 signaling pathway_Homo sapiens_hsa040660.96619717
55Vitamin B6 metabolism_Homo sapiens_hsa007500.96339335
56HTLV-I infection_Homo sapiens_hsa051660.95209301
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93053279
58One carbon pool by folate_Homo sapiens_hsa006700.92381585
59Pathways in cancer_Homo sapiens_hsa052000.92151198
60Nucleotide excision repair_Homo sapiens_hsa034200.90613970
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.90172023
62Tryptophan metabolism_Homo sapiens_hsa003800.90026112
63Base excision repair_Homo sapiens_hsa034100.89655034
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88259150
65Melanoma_Homo sapiens_hsa052180.88119975
66Calcium signaling pathway_Homo sapiens_hsa040200.87123847
67Purine metabolism_Homo sapiens_hsa002300.85622090
68Phototransduction_Homo sapiens_hsa047440.84213429
69Prostate cancer_Homo sapiens_hsa052150.80309924
70Mismatch repair_Homo sapiens_hsa034300.80192851
71Epstein-Barr virus infection_Homo sapiens_hsa051690.79256890
72Lysosome_Homo sapiens_hsa041420.78572188
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78124794
74Tight junction_Homo sapiens_hsa045300.76103260
75Ras signaling pathway_Homo sapiens_hsa040140.75969076
76Folate biosynthesis_Homo sapiens_hsa007900.75744376
77Retinol metabolism_Homo sapiens_hsa008300.73633615
78Linoleic acid metabolism_Homo sapiens_hsa005910.73106855
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72917705
80Viral myocarditis_Homo sapiens_hsa054160.72841898
81Legionellosis_Homo sapiens_hsa051340.69735352
82Galactose metabolism_Homo sapiens_hsa000520.69495406
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68860590
84Rap1 signaling pathway_Homo sapiens_hsa040150.68816380
85Ether lipid metabolism_Homo sapiens_hsa005650.68785297
86Nitrogen metabolism_Homo sapiens_hsa009100.67413120
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66930073
88Gap junction_Homo sapiens_hsa045400.66392725
89Chronic myeloid leukemia_Homo sapiens_hsa052200.65710990
90Oxytocin signaling pathway_Homo sapiens_hsa049210.64487136
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62139800
92Homologous recombination_Homo sapiens_hsa034400.61485060
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61375617
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61349999
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61063406
96Caffeine metabolism_Homo sapiens_hsa002320.60675452
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59574664
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.59240002
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58884060
100cAMP signaling pathway_Homo sapiens_hsa040240.57553085
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56920284
102MAPK signaling pathway_Homo sapiens_hsa040100.56465569
103Insulin secretion_Homo sapiens_hsa049110.56462817
104Leishmaniasis_Homo sapiens_hsa051400.56259696
105Apoptosis_Homo sapiens_hsa042100.54558168
106Lysine degradation_Homo sapiens_hsa003100.53538305
107Wnt signaling pathway_Homo sapiens_hsa043100.53373039
108Phagosome_Homo sapiens_hsa041450.52323236
109Cardiac muscle contraction_Homo sapiens_hsa042600.51677254
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51189317
111Glutathione metabolism_Homo sapiens_hsa004800.51008193
112Renin secretion_Homo sapiens_hsa049240.49873312
113Platelet activation_Homo sapiens_hsa046110.49736073
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49092797
115Dorso-ventral axis formation_Homo sapiens_hsa043200.48025124
116Cocaine addiction_Homo sapiens_hsa050300.48015479
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.47595254
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47477746
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46617498
120Taste transduction_Homo sapiens_hsa047420.46378795
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45688037
122Chemical carcinogenesis_Homo sapiens_hsa052040.44993376
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44344088
124Notch signaling pathway_Homo sapiens_hsa043300.44226736
125Circadian entrainment_Homo sapiens_hsa047130.44073561
126Tyrosine metabolism_Homo sapiens_hsa003500.43524557
127Thyroid cancer_Homo sapiens_hsa052160.43428939
128Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43284325
129Toxoplasmosis_Homo sapiens_hsa051450.43131922
130Morphine addiction_Homo sapiens_hsa050320.41209928
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41079837
132Renal cell carcinoma_Homo sapiens_hsa052110.40834103
133Oocyte meiosis_Homo sapiens_hsa041140.40775444
134Mineral absorption_Homo sapiens_hsa049780.40200514
135Viral carcinogenesis_Homo sapiens_hsa052030.39612521
136Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39032152
137Glutamatergic synapse_Homo sapiens_hsa047240.38349946
138N-Glycan biosynthesis_Homo sapiens_hsa005100.36859819
139Protein export_Homo sapiens_hsa030600.36758079
140TNF signaling pathway_Homo sapiens_hsa046680.36158752
141Serotonergic synapse_Homo sapiens_hsa047260.35357944
142FoxO signaling pathway_Homo sapiens_hsa040680.34327901
143Propanoate metabolism_Homo sapiens_hsa006400.33896853
144Ovarian steroidogenesis_Homo sapiens_hsa049130.33704034
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.33680200
146Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33179489
147ABC transporters_Homo sapiens_hsa020100.32236223
148Basal transcription factors_Homo sapiens_hsa030220.31288996
149Shigellosis_Homo sapiens_hsa051310.30046047
150Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29727472
151Histidine metabolism_Homo sapiens_hsa003400.29658064
152Vitamin digestion and absorption_Homo sapiens_hsa049770.29631692
153Fructose and mannose metabolism_Homo sapiens_hsa000510.29518750
154Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29375326
155Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28922449
156Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27404373

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