PTGES3L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.78477259
2muscle filament sliding (GO:0030049)5.14725976
3actin-myosin filament sliding (GO:0033275)5.14725976
4actin-mediated cell contraction (GO:0070252)4.71450457
5DNA deamination (GO:0045006)4.34251359
6regulation of skeletal muscle contraction (GO:0014819)4.32188901
7response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.28088704
8myofibril assembly (GO:0030239)4.19854518
9regulation of relaxation of muscle (GO:1901077)3.80217504
10cardiac myofibril assembly (GO:0055003)3.80088953
11negative regulation of protein localization to cell surface (GO:2000009)3.76696207
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.70909169
13mitochondrial respiratory chain complex I assembly (GO:0032981)3.70909169
14NADH dehydrogenase complex assembly (GO:0010257)3.70909169
15protein complex biogenesis (GO:0070271)3.67657122
16cardiac chamber formation (GO:0003207)3.67399900
17response to pheromone (GO:0019236)3.66357767
18sarcomere organization (GO:0045214)3.65587885
19skeletal muscle contraction (GO:0003009)3.56588889
20regulation of sarcomere organization (GO:0060297)3.55681776
21superoxide anion generation (GO:0042554)3.55033898
22kynurenine metabolic process (GO:0070189)3.52879625
23regulation of timing of cell differentiation (GO:0048505)3.49846588
24negative regulation of myoblast differentiation (GO:0045662)3.46439457
25L-fucose catabolic process (GO:0042355)3.44996921
26fucose catabolic process (GO:0019317)3.44996921
27L-fucose metabolic process (GO:0042354)3.44996921
28cellular ketone body metabolic process (GO:0046950)3.43367264
29mesenchymal cell differentiation involved in renal system development (GO:2001012)3.42825032
30mesenchymal cell differentiation involved in kidney development (GO:0072161)3.42825032
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.42136106
32mitochondrial respiratory chain complex assembly (GO:0033108)3.41205311
33heart process (GO:0003015)3.35211888
34heart contraction (GO:0060047)3.35211888
35cardiac muscle tissue morphogenesis (GO:0055008)3.31103222
36regulation of cilium movement (GO:0003352)3.30175105
37respiratory chain complex IV assembly (GO:0008535)3.29421159
38synaptic transmission, cholinergic (GO:0007271)3.29003820
39cardiac ventricle formation (GO:0003211)3.25821327
40actin filament-based movement (GO:0030048)3.20906574
41ubiquinone biosynthetic process (GO:0006744)3.20856453
42cerebral cortex radially oriented cell migration (GO:0021799)3.20643038
43neuronal action potential (GO:0019228)3.20162578
44platelet dense granule organization (GO:0060155)3.18963537
45indolalkylamine metabolic process (GO:0006586)3.18910533
46limb bud formation (GO:0060174)3.14114128
47regulation of development, heterochronic (GO:0040034)3.12509837
48protein neddylation (GO:0045116)3.11894738
49water-soluble vitamin biosynthetic process (GO:0042364)3.09920922
50L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.09018892
51ketone body metabolic process (GO:1902224)3.08478629
52adenosine metabolic process (GO:0046085)3.08460650
53detection of light stimulus involved in visual perception (GO:0050908)3.08281665
54detection of light stimulus involved in sensory perception (GO:0050962)3.08281665
55tryptophan catabolic process (GO:0006569)3.07387220
56indole-containing compound catabolic process (GO:0042436)3.07387220
57indolalkylamine catabolic process (GO:0046218)3.07387220
58detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.06962216
59striated muscle contraction (GO:0006941)3.06840079
60muscle tissue morphogenesis (GO:0060415)3.05036683
61adult heart development (GO:0007512)3.04701062
62regulation of myoblast differentiation (GO:0045661)2.99590475
63cytidine metabolic process (GO:0046087)2.97512741
64cytidine catabolic process (GO:0006216)2.97512741
65cytidine deamination (GO:0009972)2.97512741
66epithelial cilium movement (GO:0003351)2.97086672
67ubiquinone metabolic process (GO:0006743)2.96608460
68sarcoplasmic reticulum calcium ion transport (GO:0070296)2.96279460
69protein polyglutamylation (GO:0018095)2.93605995
70axoneme assembly (GO:0035082)2.93366328
71ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.91970222
72regulation of actin filament-based movement (GO:1903115)2.91139644
73regulation of action potential (GO:0098900)2.89786019
74protein-cofactor linkage (GO:0018065)2.88589469
75cytochrome complex assembly (GO:0017004)2.88445550
76daunorubicin metabolic process (GO:0044597)2.88167096
77polyketide metabolic process (GO:0030638)2.88167096
78doxorubicin metabolic process (GO:0044598)2.88167096
79negative regulation of telomere maintenance (GO:0032205)2.87577011
80energy coupled proton transport, down electrochemical gradient (GO:0015985)2.85177062
81ATP synthesis coupled proton transport (GO:0015986)2.85177062
82neuronal action potential propagation (GO:0019227)2.84933292
83regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.82004851
84regulation of cell communication by electrical coupling (GO:0010649)2.81755462
85piRNA metabolic process (GO:0034587)2.81132686
86somite development (GO:0061053)2.79327811
87membrane depolarization during action potential (GO:0086010)2.79078486
88regulation of rhodopsin mediated signaling pathway (GO:0022400)2.78956242
89negative regulation of skeletal muscle tissue development (GO:0048642)2.77113029
90preassembly of GPI anchor in ER membrane (GO:0016254)2.77039169
91negative regulation of cardiac muscle hypertrophy (GO:0010614)2.76522472
92membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.76065110
93mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.75703914
94actomyosin structure organization (GO:0031032)2.75602020
95negative regulation of cytosolic calcium ion concentration (GO:0051481)2.73603779
96cardiac muscle contraction (GO:0060048)2.73533669
97sperm motility (GO:0030317)2.72726009
98negative regulation of muscle hypertrophy (GO:0014741)2.71699514
99nonmotile primary cilium assembly (GO:0035058)2.70988712
100negative regulation of heart rate (GO:0010459)2.70939860
101multicellular organism reproduction (GO:0032504)2.70396865
102tryptophan metabolic process (GO:0006568)2.70325343
103dopamine transport (GO:0015872)2.69733130
104L-methionine salvage (GO:0071267)2.67689282
105L-methionine biosynthetic process (GO:0071265)2.67689282
106amino acid salvage (GO:0043102)2.67689282
107positive regulation of protein homodimerization activity (GO:0090073)2.66465095
108pyrimidine nucleobase catabolic process (GO:0006208)2.66263242
109rhodopsin mediated signaling pathway (GO:0016056)2.63262163
110regulation of hexokinase activity (GO:1903299)2.63157024
111regulation of glucokinase activity (GO:0033131)2.63157024
112regulation of striated muscle contraction (GO:0006942)2.61601536
113amine catabolic process (GO:0009310)2.59538776
114cellular biogenic amine catabolic process (GO:0042402)2.59538776
115cornea development in camera-type eye (GO:0061303)2.59199991
116cardiac muscle hypertrophy (GO:0003300)2.57516675
117positive regulation of sodium ion transmembrane transport (GO:1902307)2.57109915
118DNA demethylation (GO:0080111)2.56862339
119negative regulation of mast cell activation (GO:0033004)2.55930004
120neuromuscular synaptic transmission (GO:0007274)2.55669570
121muscle atrophy (GO:0014889)2.54933573
122negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.52981817
123regulation of somitogenesis (GO:0014807)2.52551748
124electron transport chain (GO:0022900)2.52261930
125RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.51258811
126tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.51258811
127positive regulation of cardiac muscle cell differentiation (GO:2000727)2.51072184
128ganglion development (GO:0061548)2.49697211
129cilium or flagellum-dependent cell motility (GO:0001539)2.49289389
130mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.48932544
131reciprocal DNA recombination (GO:0035825)2.48166250
132reciprocal meiotic recombination (GO:0007131)2.48166250
133action potential (GO:0001508)2.47558236
134negative regulation of nitric-oxide synthase activity (GO:0051001)2.47285755
135G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47193704
136mannosylation (GO:0097502)2.46985550
137G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.46453772
138energy homeostasis (GO:0097009)2.46014069
139negative regulation of keratinocyte proliferation (GO:0010839)2.45391271
140negative regulation of homotypic cell-cell adhesion (GO:0034111)2.45237445
141respiratory electron transport chain (GO:0022904)2.44938304
142quinone biosynthetic process (GO:1901663)2.44812734
143indole-containing compound metabolic process (GO:0042430)2.44414252
144extracellular regulation of signal transduction (GO:1900115)2.44317242
145extracellular negative regulation of signal transduction (GO:1900116)2.44317242
146striated muscle hypertrophy (GO:0014897)2.44088671
147positive regulation of cardiac muscle cell proliferation (GO:0060045)2.43928932
148cell proliferation in forebrain (GO:0021846)2.43628124
149DNA methylation involved in gamete generation (GO:0043046)2.43579886
150acrosome reaction (GO:0007340)2.43499574
151positive regulation of cardiac muscle tissue development (GO:0055025)2.42170143
152otic vesicle formation (GO:0030916)2.41682963
153methionine biosynthetic process (GO:0009086)2.41346478
154phosphatidylinositol acyl-chain remodeling (GO:0036149)2.40953593
155keratinocyte development (GO:0003334)2.40850860
156axonemal dynein complex assembly (GO:0070286)2.40798093
157cardiac cell development (GO:0055006)2.40573101
158centriole assembly (GO:0098534)2.39675333
159positive regulation of action potential (GO:0045760)2.39620651
160regulation of skeletal muscle fiber development (GO:0048742)2.39471075
161cardiac muscle cell development (GO:0055013)2.39088750
162cellular response to gamma radiation (GO:0071480)2.38489169
163motile cilium assembly (GO:0044458)2.38319291
164regulation of cardiac muscle cell differentiation (GO:2000725)2.38303239
165sympathetic nervous system development (GO:0048485)2.35923029
166primary amino compound metabolic process (GO:1901160)2.35391541
167protein localization to cilium (GO:0061512)2.35261520
168mesonephros development (GO:0001823)2.34746414
169cell differentiation involved in metanephros development (GO:0072202)2.34309645
170female gonad development (GO:0008585)2.34228942
171cardiac right ventricle morphogenesis (GO:0003215)2.33620731
172muscle hypertrophy (GO:0014896)2.33505827
173atrial septum morphogenesis (GO:0060413)2.33091816
174DNA integration (GO:0015074)2.31187092
175regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.30968330
176neural crest cell development (GO:0014032)2.30251783
177eye photoreceptor cell differentiation (GO:0001754)2.29695843
178photoreceptor cell differentiation (GO:0046530)2.29695843
179pyrimidine ribonucleoside catabolic process (GO:0046133)2.28854709
180skeletal muscle adaptation (GO:0043501)2.28679925
181negative regulation of stem cell proliferation (GO:2000647)2.27568497
182positive regulation of cardiac muscle tissue growth (GO:0055023)2.26350122
183cell differentiation involved in kidney development (GO:0061005)2.25157736
184mesenchymal cell differentiation (GO:0048762)2.25153776
185kidney morphogenesis (GO:0060993)2.24039463
186negative regulation of striated muscle cell apoptotic process (GO:0010664)2.22791544
187nucleotide transmembrane transport (GO:1901679)2.21806529
188regulation of activation of Janus kinase activity (GO:0010533)2.21522192
189righting reflex (GO:0060013)2.21217181

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.81399867
2GBX2_23144817_ChIP-Seq_PC3_Human3.26699302
3EZH2_22144423_ChIP-Seq_EOC_Human3.18818771
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.92630815
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.81129845
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.66183527
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.63486448
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.39583509
9VDR_22108803_ChIP-Seq_LS180_Human2.38306549
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.34123847
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.31791331
12PCGF2_27294783_Chip-Seq_NPCs_Mouse2.30713787
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26514404
14SUZ12_27294783_Chip-Seq_NPCs_Mouse2.17150603
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07977996
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.07361371
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.06820607
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03762399
19NFE2_27457419_Chip-Seq_LIVER_Mouse2.03256475
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98028682
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.95213982
22EZH2_27294783_Chip-Seq_NPCs_Mouse1.89727852
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87628830
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81748843
25EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.80710761
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75074657
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.74244265
28E2F1_18555785_Chip-Seq_ESCs_Mouse1.73823159
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72962064
30TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.71679167
31STAT3_18555785_Chip-Seq_ESCs_Mouse1.71478164
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70961567
33SUZ12_18555785_Chip-Seq_ESCs_Mouse1.70924100
34P53_22387025_ChIP-Seq_ESCs_Mouse1.68882794
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.68759761
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.66837998
37P300_19829295_ChIP-Seq_ESCs_Human1.65899026
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.64725045
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63952813
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62986858
41TP53_22573176_ChIP-Seq_HFKS_Human1.62055629
42EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.61688144
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.61225963
44RNF2_27304074_Chip-Seq_NSC_Mouse1.59720374
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59427795
46NMYC_18555785_Chip-Seq_ESCs_Mouse1.59426867
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.55398142
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.55042540
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53673916
50KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.53660304
51P300_18555785_Chip-Seq_ESCs_Mouse1.50599172
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.50363201
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50222874
54CMYC_18555785_Chip-Seq_ESCs_Mouse1.49762397
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49634705
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49634705
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49448502
58SOX2_18555785_Chip-Seq_ESCs_Mouse1.48656759
59OCT4_18555785_Chip-Seq_ESCs_Mouse1.48045151
60ZFX_18555785_Chip-Seq_ESCs_Mouse1.47677269
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47576057
62NANOG_19829295_ChIP-Seq_ESCs_Human1.47478764
63SOX2_19829295_ChIP-Seq_ESCs_Human1.47478764
64EP300_21415370_ChIP-Seq_HL-1_Mouse1.46977929
65RUNX1_27457419_Chip-Seq_LIVER_Mouse1.46188188
66CBP_20019798_ChIP-Seq_JUKART_Human1.45798668
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45798668
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.43845997
69TAF15_26573619_Chip-Seq_HEK293_Human1.43546214
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.43404690
71CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43223920
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42845715
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41985620
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.39567592
75SMAD4_21799915_ChIP-Seq_A2780_Human1.39044771
76RNF2_27304074_Chip-Seq_ESCs_Mouse1.37806947
77IRF1_19129219_ChIP-ChIP_H3396_Human1.37768947
78PU1_27457419_Chip-Seq_LIVER_Mouse1.36477910
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.36372240
80BCAT_22108803_ChIP-Seq_LS180_Human1.36245783
81AR_25329375_ChIP-Seq_VCAP_Human1.35946525
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35796762
83TP53_18474530_ChIP-ChIP_U2OS_Human1.35457687
84FUS_26573619_Chip-Seq_HEK293_Human1.35277460
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34980243
86ER_23166858_ChIP-Seq_MCF-7_Human1.34511762
87ESRRB_18555785_Chip-Seq_ESCs_Mouse1.32996901
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32110240
89MYC_18940864_ChIP-ChIP_HL60_Human1.32101011
90KLF4_18555785_Chip-Seq_ESCs_Mouse1.31925874
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31126438
92TAL1_26923725_Chip-Seq_HPCs_Mouse1.30955522
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30587514
94EST1_17652178_ChIP-ChIP_JURKAT_Human1.30252553
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30139241
96STAT3_23295773_ChIP-Seq_U87_Human1.29388607
97IGF1R_20145208_ChIP-Seq_DFB_Human1.28446843
98OCT4_21477851_ChIP-Seq_ESCs_Mouse1.28345199
99GATA3_21878914_ChIP-Seq_MCF-7_Human1.26953007
100REST_21632747_ChIP-Seq_MESCs_Mouse1.26921318
101NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26874871
102FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26429699
103FOXA1_25329375_ChIP-Seq_VCAP_Human1.26429699
104SMAD1_18555785_Chip-Seq_ESCs_Mouse1.26030220
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25846789
106LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25809074
107CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25656214
108SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.24573887
109ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24273355
110TCF4_23295773_ChIP-Seq_U87_Human1.23481810
111CTCF_18555785_Chip-Seq_ESCs_Mouse1.22930035
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22245342
113AR_21572438_ChIP-Seq_LNCaP_Human1.22044494
114NCOR_22424771_ChIP-Seq_293T_Human1.21516364
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21304851
116AR_20517297_ChIP-Seq_VCAP_Human1.19719547
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18960221
118PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17721858
119SALL1_21062744_ChIP-ChIP_HESCs_Human1.17698607
120EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17198454
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16988500
122SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16281285
123CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16153423
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14582359
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14582359
126PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12302899
127TCF4_22108803_ChIP-Seq_LS180_Human1.11538723
128NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10792258
129CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10372785
130HOXB7_26014856_ChIP-Seq_BT474_Human1.10281342
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08558121
132SMAD4_21741376_ChIP-Seq_EPCs_Human1.06366246
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06283196
134MYC_19829295_ChIP-Seq_ESCs_Human1.06249671
135NANOG_20526341_ChIP-Seq_ESCs_Human1.06105188
136FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06071868
137MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05303456
138FLI1_21867929_ChIP-Seq_TH2_Mouse1.04535039
139RUNX2_22187159_ChIP-Seq_PCA_Human1.04250304
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04163874
141SRF_21415370_ChIP-Seq_HL-1_Mouse1.03682378
142EWS_26573619_Chip-Seq_HEK293_Human1.03312202
143FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02228771
144HTT_18923047_ChIP-ChIP_STHdh_Human1.02047743
145KDM2B_26808549_Chip-Seq_REH_Human1.01623292
146VDR_23849224_ChIP-Seq_CD4+_Human1.01514699
147CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01221390
148LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01216154
149TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00248962
150REST_18959480_ChIP-ChIP_MESCs_Mouse0.99918303
151SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98973066
152AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97817902
153PRDM14_20953172_ChIP-Seq_ESCs_Human0.97691869
154ELK1_19687146_ChIP-ChIP_HELA_Human0.97555079
155OCT4_20526341_ChIP-Seq_ESCs_Human0.97450089
156FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97103505

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.59013044
2MP0000749_muscle_degeneration3.22568603
3MP0003136_yellow_coat_color3.03350659
4MP0003941_abnormal_skin_development2.98046370
5MP0003646_muscle_fatigue2.96843981
6MP0002102_abnormal_ear_morphology2.77172104
7MP0001188_hyperpigmentation2.76495988
8MP0000751_myopathy2.55644825
9MP0008877_abnormal_DNA_methylation2.55271459
10MP0006292_abnormal_olfactory_placode2.48102508
11MP0005451_abnormal_body_composition2.29525336
12MP0001968_abnormal_touch/_nociception2.25626727
13MP0005171_absent_coat_pigmentation2.23889519
14MP0004145_abnormal_muscle_electrophysio2.21453648
15MP0005503_abnormal_tendon_morphology2.19397984
16MP0005551_abnormal_eye_electrophysiolog2.12160295
17MP0002837_dystrophic_cardiac_calcinosis1.99205897
18MP0004084_abnormal_cardiac_muscle1.96692085
19MP0004142_abnormal_muscle_tone1.96398901
20MP0003950_abnormal_plasma_membrane1.94613200
21MP0004036_abnormal_muscle_relaxation1.88661836
22MP0004147_increased_porphyrin_level1.88501940
23MP0004215_abnormal_myocardial_fiber1.88348016
24MP0002277_abnormal_respiratory_mucosa1.86871164
25MP0005620_abnormal_muscle_contractility1.82178815
26MP0006072_abnormal_retinal_apoptosis1.80239542
27MP0002972_abnormal_cardiac_muscle1.78023518
28MP0004381_abnormal_hair_follicle1.73611985
29MP0003195_calcinosis1.72630237
30MP0008872_abnormal_physiological_respon1.72017043
31MP0009745_abnormal_behavioral_response1.70415659
32MP0008875_abnormal_xenobiotic_pharmacok1.68472307
33MP0009046_muscle_twitch1.67130795
34MP0003828_pulmonary_edema1.66511092
35MP0004484_altered_response_of1.65645901
36MP0002106_abnormal_muscle_physiology1.64150555
37MP0000049_abnormal_middle_ear1.61748241
38MP0005369_muscle_phenotype1.59938706
39MP0002272_abnormal_nervous_system1.58573396
40MP0003011_delayed_dark_adaptation1.58193565
41MP0005646_abnormal_pituitary_gland1.57928010
42MP0005330_cardiomyopathy1.55639240
43MP0002127_abnormal_cardiovascular_syste1.52101182
44MP0005409_darkened_coat_color1.51354445
45MP0001529_abnormal_vocalization1.49539681
46MP0002163_abnormal_gland_morphology1.49298162
47MP0001984_abnormal_olfaction1.47832808
48MP0004130_abnormal_muscle_cell1.47636479
49MP0009250_abnormal_appendicular_skeleto1.46651669
50MP0003137_abnormal_impulse_conducting1.46632560
51MP0004043_abnormal_pH_regulation1.45898575
52MP0006036_abnormal_mitochondrial_physio1.45264153
53MP0002638_abnormal_pupillary_reflex1.44301008
54MP0005379_endocrine/exocrine_gland_phen1.44250787
55MP0002249_abnormal_larynx_morphology1.43366113
56MP0009697_abnormal_copulation1.40894030
57MP0000762_abnormal_tongue_morphology1.38492800
58MP0000569_abnormal_digit_pigmentation1.36259335
59MP0002653_abnormal_ependyma_morphology1.32529749
60MP0000026_abnormal_inner_ear1.30456641
61MP0004510_myositis1.29437418
62MP0002108_abnormal_muscle_morphology1.24333825
63MP0008775_abnormal_heart_ventricle1.23520723
64MP0000015_abnormal_ear_pigmentation1.23232495
65MP0000750_abnormal_muscle_regeneration1.22219987
66MP0004742_abnormal_vestibular_system1.21065622
67MP0004133_heterotaxia1.20507437
68MP0001501_abnormal_sleep_pattern1.19648062
69MP0000427_abnormal_hair_cycle1.18749062
70MP0002938_white_spotting1.18541130
71MP0005645_abnormal_hypothalamus_physiol1.18036647
72MP0002572_abnormal_emotion/affect_behav1.17517495
73MP0004885_abnormal_endolymph1.14754472
74MP0000759_abnormal_skeletal_muscle1.14465064
75MP0001986_abnormal_taste_sensitivity1.13830006
76MP0002733_abnormal_thermal_nociception1.12751490
77MP0005257_abnormal_intraocular_pressure1.12710330
78MP0005670_abnormal_white_adipose1.12379869
79MP0004087_abnormal_muscle_fiber1.12233112
80MP0002234_abnormal_pharynx_morphology1.11790761
81MP0002067_abnormal_sensory_capabilities1.10896958
82MP0005377_hearing/vestibular/ear_phenot1.10528053
83MP0003878_abnormal_ear_physiology1.10528053
84MP0002132_abnormal_respiratory_system1.10238292
85MP0002064_seizures1.09255973
86MP0001905_abnormal_dopamine_level1.08672625
87MP0005423_abnormal_somatic_nervous1.07972572
88MP0000230_abnormal_systemic_arterial1.06672724
89MP0001970_abnormal_pain_threshold1.06532299
90MP0000372_irregular_coat_pigmentation1.05134923
91MP0005084_abnormal_gallbladder_morpholo1.03402960
92MP0001346_abnormal_lacrimal_gland1.01997814
93MP0002332_abnormal_exercise_endurance1.01058275
94MP0004134_abnormal_chest_morphology1.00051686
95MP0005386_behavior/neurological_phenoty0.99098596
96MP0004924_abnormal_behavior0.99098596
97MP0002148_abnormal_hypersensitivity_rea0.98503719
98MP0000631_abnormal_neuroendocrine_gland0.97877003
99MP0006138_congestive_heart_failure0.97831767
100MP0004085_abnormal_heartbeat0.97219605
101MP0002557_abnormal_social/conspecific_i0.96252968
102MP0010386_abnormal_urinary_bladder0.95878949
103MP0000383_abnormal_hair_follicle0.94214123
104MP0005385_cardiovascular_system_phenoty0.92726093
105MP0001544_abnormal_cardiovascular_syste0.92726093
106MP0003635_abnormal_synaptic_transmissio0.92064551
107MP0003698_abnormal_male_reproductive0.91981017
108MP0003787_abnormal_imprinting0.91737571
109MP0006276_abnormal_autonomic_nervous0.91134018
110MP0005174_abnormal_tail_pigmentation0.90466777
111MP0001486_abnormal_startle_reflex0.90417833
112MP0002063_abnormal_learning/memory/cond0.89536626
113MP0003385_abnormal_body_wall0.88796305
114MP0005167_abnormal_blood-brain_barrier0.87330310
115MP0002734_abnormal_mechanical_nocicepti0.87099582
116MP0005389_reproductive_system_phenotype0.86810716
117MP0003938_abnormal_ear_development0.86524506
118MP0003121_genomic_imprinting0.85401914
119MP0005508_abnormal_skeleton_morphology0.85166416
120MP0008058_abnormal_DNA_repair0.84017744
121MP0002933_joint_inflammation0.83948605
122MP0008789_abnormal_olfactory_epithelium0.82952417
123MP0002160_abnormal_reproductive_system0.81828436
124MP0002752_abnormal_somatic_nervous0.80797203
125MP0003315_abnormal_perineum_morphology0.80416167
126MP0005266_abnormal_metabolism0.80299623
127MP0005410_abnormal_fertilization0.80280867
128MP0003937_abnormal_limbs/digits/tail_de0.80149489
129MP0003122_maternal_imprinting0.78761898
130MP0003724_increased_susceptibility_to0.78574835
131MP0006035_abnormal_mitochondrial_morpho0.78347777
132MP0000678_abnormal_parathyroid_gland0.78328936
133MP0002184_abnormal_innervation0.78190825
134MP0003880_abnormal_central_pattern0.77988879
135MP0008995_early_reproductive_senescence0.77262392
136MP0001963_abnormal_hearing_physiology0.77201062
137MP0001879_abnormal_lymphatic_vessel0.77125498
138MP0002928_abnormal_bile_duct0.76975029
139MP0002229_neurodegeneration0.76726370
140MP0005332_abnormal_amino_acid0.76294784
141MP0002095_abnormal_skin_pigmentation0.75384496
142MP0008260_abnormal_autophagy0.74992514
143MP0005075_abnormal_melanosome_morpholog0.74322355
144MP0010630_abnormal_cardiac_muscle0.74313456
145MP0005195_abnormal_posterior_eye0.73915457
146MP0001929_abnormal_gametogenesis0.73083894
147MP0008004_abnormal_stomach_pH0.71524773
148MP0002177_abnormal_outer_ear0.71284796
149MP0001485_abnormal_pinna_reflex0.70163496
150MP0002736_abnormal_nociception_after0.69936146
151MP0003755_abnormal_palate_morphology0.68190532
152MP0002735_abnormal_chemical_nociception0.68134896
153MP0002876_abnormal_thyroid_physiology0.67070025
154MP0003279_aneurysm0.66523970
155MP0000613_abnormal_salivary_gland0.65892966
156MP0010030_abnormal_orbit_morphology0.65693626
157MP0005253_abnormal_eye_physiology0.65076214
158MP0000343_altered_response_to0.63150044
159MP0005595_abnormal_vascular_smooth0.63111002
160MP0004782_abnormal_surfactant_physiolog0.62942328
161MP0005248_abnormal_Harderian_gland0.62359163
162MP0000767_abnormal_smooth_muscle0.62313909

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.11201408
2Muscle hypertrophy of the lower extremities (HP:0008968)4.46169921
3Calf muscle hypertrophy (HP:0008981)4.39261276
4Chromsome breakage (HP:0040012)4.28169168
5Pancreatic cysts (HP:0001737)3.85664844
6Pancreatic fibrosis (HP:0100732)3.68651863
7Duplicated collecting system (HP:0000081)3.62027542
8Molar tooth sign on MRI (HP:0002419)3.55649168
9Abnormality of midbrain morphology (HP:0002418)3.55649168
10Exercise-induced myalgia (HP:0003738)3.54747780
11Congenital stationary night blindness (HP:0007642)3.49995633
12Abnormality of the calf musculature (HP:0001430)3.39930218
13Exercise-induced muscle cramps (HP:0003710)3.23515570
14Nephronophthisis (HP:0000090)3.20548348
15Distal lower limb muscle weakness (HP:0009053)3.19625699
16Atrial fibrillation (HP:0005110)3.18898515
17Abnormality of the renal collecting system (HP:0004742)3.16189948
18Ventricular tachycardia (HP:0004756)3.03805293
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.00819395
20Dynein arm defect of respiratory motile cilia (HP:0012255)2.97684777
21Absent/shortened dynein arms (HP:0200106)2.97684777
22Sudden death (HP:0001699)2.96339185
23Type II lissencephaly (HP:0007260)2.96096290
24Abnormality of the renal cortex (HP:0011035)2.95938149
25Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.93014045
26Muscle fiber inclusion bodies (HP:0100299)2.92806299
27Nemaline bodies (HP:0003798)2.92347462
28Primary atrial arrhythmia (HP:0001692)2.86385588
29Subaortic stenosis (HP:0001682)2.84399081
30Abnormality of the left ventricular outflow tract (HP:0011103)2.84399081
31Upper limb muscle weakness (HP:0003484)2.76804657
32Attenuation of retinal blood vessels (HP:0007843)2.71333612
33Supraventricular tachycardia (HP:0004755)2.70583406
34Duplication of thumb phalanx (HP:0009942)2.67772174
35Abnormality of the renal medulla (HP:0100957)2.66063521
36Supraventricular arrhythmia (HP:0005115)2.60554520
37Increased CSF lactate (HP:0002490)2.57623777
38Aplasia cutis congenita (HP:0001057)2.57033143
39Hepatic necrosis (HP:0002605)2.55644871
40Medial flaring of the eyebrow (HP:0010747)2.54240959
41Lipoatrophy (HP:0100578)2.53165566
42Congenital malformation of the right heart (HP:0011723)2.50697353
43Double outlet right ventricle (HP:0001719)2.50697353
44Acute encephalopathy (HP:0006846)2.48648877
45Pulmonary artery stenosis (HP:0004415)2.48515480
46Abnormal rod and cone electroretinograms (HP:0008323)2.47856333
47Hypoplastic left heart (HP:0004383)2.45293966
48Hypoplastic heart (HP:0001961)2.43113362
49Hepatocellular necrosis (HP:0001404)2.42488996
50Prolonged QT interval (HP:0001657)2.42288839
51Renal cortical cysts (HP:0000803)2.36597817
52EMG: myopathic abnormalities (HP:0003458)2.36010215
53Abolished electroretinogram (ERG) (HP:0000550)2.33621288
54Polydipsia (HP:0001959)2.32947276
55Abnormal drinking behavior (HP:0030082)2.32947276
56Distal arthrogryposis (HP:0005684)2.32937858
57Acute necrotizing encephalopathy (HP:0006965)2.32738155
58Septo-optic dysplasia (HP:0100842)2.32541383
59Congenital sensorineural hearing impairment (HP:0008527)2.32179441
60Muscle fiber splitting (HP:0003555)2.30789314
61Cystic liver disease (HP:0006706)2.30492331
62Abnormal ciliary motility (HP:0012262)2.28788750
63Chronic hepatic failure (HP:0100626)2.27992317
64Tubular atrophy (HP:0000092)2.27630654
65Abnormality of alanine metabolism (HP:0010916)2.26708913
66Hyperalaninemia (HP:0003348)2.26708913
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26708913
68Abnormal respiratory motile cilium morphology (HP:0005938)2.25974323
69Abnormal respiratory epithelium morphology (HP:0012253)2.25974323
70Pendular nystagmus (HP:0012043)2.22884884
71White forelock (HP:0002211)2.21393146
72Inability to walk (HP:0002540)2.20952180
73Type 1 muscle fiber predominance (HP:0003803)2.19965575
74True hermaphroditism (HP:0010459)2.17874840
75Aplasia of the musculature (HP:0100854)2.17062044
76Lipid accumulation in hepatocytes (HP:0006561)2.14534143
77Gait imbalance (HP:0002141)2.14330929
78Abnormality of incisor morphology (HP:0011063)2.13375972
79Hyperventilation (HP:0002883)2.11768702
80Decreased central vision (HP:0007663)2.10365978
81Large for gestational age (HP:0001520)2.09193774
82Optic disc pallor (HP:0000543)2.08998343
83Lissencephaly (HP:0001339)2.07234203
84Abnormal respiratory motile cilium physiology (HP:0012261)2.06959435
85Broad-based gait (HP:0002136)2.06559152
86Abnormality of the preputium (HP:0100587)2.04641367
87Prostate neoplasm (HP:0100787)2.03812428
88Absent phalangeal crease (HP:0006109)2.03359323
89Sclerocornea (HP:0000647)2.01983824
90Dilated cardiomyopathy (HP:0001644)2.01349577
91Febrile seizures (HP:0002373)2.00918354
92Patchy hypopigmentation of hair (HP:0011365)2.00915421
93Congenital hepatic fibrosis (HP:0002612)1.99950469
94Congenital primary aphakia (HP:0007707)1.99306657
95Cerebellar dysplasia (HP:0007033)1.99214689
96Decreased electroretinogram (ERG) amplitude (HP:0000654)1.98968242
97Increased hepatocellular lipid droplets (HP:0006565)1.97354644
98Syncope (HP:0001279)1.96577850
99Meckel diverticulum (HP:0002245)1.96442238
100Methylmalonic acidemia (HP:0002912)1.95882712
101Severe muscular hypotonia (HP:0006829)1.94076488
102Aplasia/Hypoplasia of the uvula (HP:0010293)1.93659753
103Nephrogenic diabetes insipidus (HP:0009806)1.93200646
104Pachygyria (HP:0001302)1.92820180
105Keratoconus (HP:0000563)1.92507140
106Increased corneal curvature (HP:0100692)1.92507140
107Muscle fiber atrophy (HP:0100295)1.92403588
108Increased serum lactate (HP:0002151)1.92121851
109Weak cry (HP:0001612)1.91690795
110Renal Fanconi syndrome (HP:0001994)1.91371130
111Nephroblastoma (Wilms tumor) (HP:0002667)1.91079300
112Exercise intolerance (HP:0003546)1.90252414
113Left ventricular hypertrophy (HP:0001712)1.87660379
114Congenital, generalized hypertrichosis (HP:0004540)1.87563191
115Adrenal hypoplasia (HP:0000835)1.87333864
116Anomalous pulmonary venous return (HP:0010772)1.87255932
117Abnormality of the ileum (HP:0001549)1.86733455
118Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86425572
119Optic neuritis (HP:0100653)1.86319504
120Retrobulbar optic neuritis (HP:0100654)1.86319504
121Lactic acidosis (HP:0003128)1.86213259
122Anencephaly (HP:0002323)1.85963546
123Ectopic kidney (HP:0000086)1.85401206
124Progressive macrocephaly (HP:0004481)1.84935319
125Embryonal renal neoplasm (HP:0011794)1.84479990
126Hyperglycinuria (HP:0003108)1.84096566
127Neck muscle weakness (HP:0000467)1.84047644
128Hypoplasia of the fovea (HP:0007750)1.84047462
129Aplasia/Hypoplasia of the fovea (HP:0008060)1.84047462
1303-Methylglutaconic aciduria (HP:0003535)1.83816701
131Increased intramyocellular lipid droplets (HP:0012240)1.83077646
132Limb dystonia (HP:0002451)1.82220571
133Optic nerve hypoplasia (HP:0000609)1.82001630
134Progressive inability to walk (HP:0002505)1.81640749
135Abnormal mitochondria in muscle tissue (HP:0008316)1.81502964
136Aplasia/Hypoplasia of the tongue (HP:0010295)1.80661392
137Abnormality of DNA repair (HP:0003254)1.79449859
138Hypothermia (HP:0002045)1.79444580
139Atelectasis (HP:0100750)1.78302617
140Concave nail (HP:0001598)1.78198651
141Aplasia/Hypoplasia of the tibia (HP:0005772)1.76275449
142Polyuria (HP:0000103)1.75645147
143Abnormal biliary tract physiology (HP:0012439)1.75492761
144Bile duct proliferation (HP:0001408)1.75492761
145Steppage gait (HP:0003376)1.74501281
146Mitochondrial inheritance (HP:0001427)1.73862075
147Bony spicule pigmentary retinopathy (HP:0007737)1.73535091
148Abnormality of the dental pulp (HP:0006479)1.72285434
149Tubulointerstitial nephritis (HP:0001970)1.71546946
150Cerebral edema (HP:0002181)1.71276698
151Abnormal finger flexion creases (HP:0006143)1.71070502
152Ketosis (HP:0001946)1.70517007
153Parakeratosis (HP:0001036)1.70367126
154Type 2 muscle fiber atrophy (HP:0003554)1.70332275
155Morphological abnormality of the middle ear (HP:0008609)1.69273112
156Distal lower limb amyotrophy (HP:0008944)1.69017169
157Fetal akinesia sequence (HP:0001989)1.68775023
158Abnormality of the labia minora (HP:0012880)1.68617217
159Preauricular pit (HP:0004467)1.68245351
160Periauricular skin pits (HP:0100277)1.68245351
161Conical tooth (HP:0000698)1.67721225
162Male pseudohermaphroditism (HP:0000037)1.67657748
163Aplasia/Hypoplasia of the spleen (HP:0010451)1.67390521
164Abnormality of molar morphology (HP:0011070)1.67381160
165Abnormality of molar (HP:0011077)1.67381160
166Increased muscle lipid content (HP:0009058)1.66365968
167Myotonia (HP:0002486)1.66345387
168Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.65870915
169Rimmed vacuoles (HP:0003805)1.65836003
170Abnormality of the pulmonary veins (HP:0011718)1.65834667
171Abnormal EKG (HP:0003115)1.64625313
172Abnormality of renal resorption (HP:0011038)1.64611045

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.27650740
2FRK4.12487816
3ZAK3.76333692
4CASK3.65726408
5MAP4K23.35349242
6TAOK32.91309583
7INSRR2.56514602
8STK162.50903372
9NUAK12.30721944
10IRAK32.19560830
11PIK3CA2.11348411
12NEK62.10706020
13MUSK2.02288377
14GRK11.97816862
15STK38L1.97261857
16MKNK21.95873753
17MYLK1.93029210
18TXK1.89629676
19TLK11.85147844
20TNIK1.85064274
21BCKDK1.83544657
22TIE11.74893849
23EIF2AK21.73939895
24ACVR1B1.72499040
25STK241.69101047
26IRAK41.63396557
27BMPR21.61280496
28MAP3K141.57732147
29BMPR1B1.53790706
30PIK3CG1.53495990
31GRK71.53142796
32MAP3K41.52864265
33PKN11.51327530
34PHKG21.47759968
35PHKG11.47759968
36PINK11.47309439
37YES11.44944225
38MARK11.42223277
39TRPM71.42022986
40ADRBK21.37982952
41DAPK21.36922243
42MAPK131.33225575
43MAP2K71.24363496
44IRAK11.19794223
45TTN1.17722638
46DMPK1.17044803
47MKNK11.15779798
48PLK41.12871359
49OXSR11.08960962
50PAK31.08681093
51PDK21.06635399
52MAPKAPK31.02883101
53BLK1.02180045
54PRPF4B1.01941993
55ERBB31.00090011
56IRAK20.98575663
57NME10.98200022
58LATS10.97727005
59TRIM280.97686834
60EPHA30.96648389
61SGK20.92606123
62PBK0.91979835
63SIK30.91038120
64PRKCE0.91019769
65SRPK10.90711037
66CDK30.87935463
67TGFBR10.87019685
68CAMKK20.83088255
69EPHB20.81220630
70STK390.81114600
71AKT30.79293693
72CSNK1G20.76329562
73TEC0.74659901
74CDK80.74071340
75MAPK120.72819439
76PRKCG0.71951214
77PLK20.71130473
78CSNK1G30.70793721
79IKBKB0.69694829
80BRSK20.68311048
81PTK2B0.67640966
82CSNK1G10.66432867
83MAP2K40.65328334
84MAPK70.62517356
85CDC42BPA0.62245779
86NME20.60549519
87ROCK10.60452339
88BCR0.59133438
89CCNB10.58838806
90WNK40.58181103
91PNCK0.57435213
92CAMK10.57244678
93NTRK20.56248898
94MAPKAPK50.56055422
95PRKG10.53183989
96WNK10.52183590
97PIM20.51801736
98STK40.48862627
99VRK20.48407332
100PRKAA20.48266809
101DYRK20.48097134
102RIPK40.47671986
103CAMK2A0.47645121
104SGK2230.46898784
105SGK4940.46898784
106NLK0.45322719
107SYK0.44692708
108CAMK2D0.42866878
109TAOK20.41583600
110GRK50.41392207
111IKBKE0.40980977
112PRKAA10.40886470
113PRKACA0.40808077
114CSNK1A1L0.40679478
115ITK0.40458649
116CLK10.40376752
117MINK10.39792721
118MAPK150.39334448
119PRKCQ0.38857112
120PRKD20.38418500
121VRK10.38072506
122NTRK30.36205588
123CSNK1A10.36152676
124EPHA40.35826676
125TNK20.34914515
126STK30.34829300
127PLK30.34209136
128MAP3K70.34079078
129PRKCA0.33962125
130KIT0.33820139
131SGK10.33720161
132DYRK1A0.33370003
133PDK40.33307410
134PDK30.33307410
135MAP2K10.32094644
136MST40.31431657
137PRKACB0.30791562
138NEK90.30142262
139FLT30.29922097
140CDK190.29801760
141RPS6KA50.29382064
142WNK30.29153074
143TAF10.28922769
144CAMK40.28844965
145NEK10.28677513
146CSNK1D0.28325076
147ADRBK10.27069832
148LYN0.26765500
149JAK30.26758203
150MAP2K60.26160903

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042603.01953043
2Oxidative phosphorylation_Homo sapiens_hsa001902.97664007
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.89285909
4Nitrogen metabolism_Homo sapiens_hsa009102.69006170
5Fanconi anemia pathway_Homo sapiens_hsa034602.49621926
6Parkinsons disease_Homo sapiens_hsa050122.45852538
7Dilated cardiomyopathy_Homo sapiens_hsa054142.42686261
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13620202
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.05869631
10Butanoate metabolism_Homo sapiens_hsa006502.05382966
11Alzheimers disease_Homo sapiens_hsa050102.05020647
12Huntingtons disease_Homo sapiens_hsa050161.95395717
13Autoimmune thyroid disease_Homo sapiens_hsa053201.93996582
14Caffeine metabolism_Homo sapiens_hsa002321.83340155
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77024034
16Arachidonic acid metabolism_Homo sapiens_hsa005901.74271809
17Phototransduction_Homo sapiens_hsa047441.67075100
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66626724
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.66494531
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.66010899
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64978535
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.64156124
23Allograft rejection_Homo sapiens_hsa053301.61035873
24Propanoate metabolism_Homo sapiens_hsa006401.58171437
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.58134768
26Selenocompound metabolism_Homo sapiens_hsa004501.58035821
27Tryptophan metabolism_Homo sapiens_hsa003801.57021940
28Graft-versus-host disease_Homo sapiens_hsa053321.56992993
29Sphingolipid metabolism_Homo sapiens_hsa006001.48723247
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46455874
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.44678703
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44225048
33Rheumatoid arthritis_Homo sapiens_hsa053231.38865251
34One carbon pool by folate_Homo sapiens_hsa006701.37804302
35Basal transcription factors_Homo sapiens_hsa030221.35303536
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.33759053
37Peroxisome_Homo sapiens_hsa041461.32788282
38Asthma_Homo sapiens_hsa053101.26809833
39Calcium signaling pathway_Homo sapiens_hsa040201.23901563
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.21506332
41Homologous recombination_Homo sapiens_hsa034401.21222104
42Nicotine addiction_Homo sapiens_hsa050331.15084849
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11777697
44Taste transduction_Homo sapiens_hsa047421.10139682
45Malaria_Homo sapiens_hsa051441.06994363
46GABAergic synapse_Homo sapiens_hsa047271.03694203
47Sulfur metabolism_Homo sapiens_hsa009201.02767111
48Ether lipid metabolism_Homo sapiens_hsa005651.01910644
49Non-homologous end-joining_Homo sapiens_hsa034500.95347955
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95278307
51Basal cell carcinoma_Homo sapiens_hsa052170.94576537
52Viral myocarditis_Homo sapiens_hsa054160.94127313
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93651377
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92284286
55Serotonergic synapse_Homo sapiens_hsa047260.92088329
56Measles_Homo sapiens_hsa051620.91878956
57Insulin secretion_Homo sapiens_hsa049110.91697029
58Protein export_Homo sapiens_hsa030600.91200383
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89936020
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.89219872
61Purine metabolism_Homo sapiens_hsa002300.88487916
62Hematopoietic cell lineage_Homo sapiens_hsa046400.86740983
63ECM-receptor interaction_Homo sapiens_hsa045120.85749715
64Chemical carcinogenesis_Homo sapiens_hsa052040.83661931
65beta-Alanine metabolism_Homo sapiens_hsa004100.83654435
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83542346
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82414605
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82203996
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81133883
70RNA polymerase_Homo sapiens_hsa030200.80942523
71Morphine addiction_Homo sapiens_hsa050320.79853278
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.79777258
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78639041
74Linoleic acid metabolism_Homo sapiens_hsa005910.78480639
75Fatty acid elongation_Homo sapiens_hsa000620.77653173
76Circadian rhythm_Homo sapiens_hsa047100.75941680
77Ovarian steroidogenesis_Homo sapiens_hsa049130.72219351
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72195535
79Glutamatergic synapse_Homo sapiens_hsa047240.70764020
80ABC transporters_Homo sapiens_hsa020100.70689076
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70589398
82RNA degradation_Homo sapiens_hsa030180.70510367
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70121964
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70003191
85Metabolic pathways_Homo sapiens_hsa011000.68865735
86Regulation of autophagy_Homo sapiens_hsa041400.68161733
87Other glycan degradation_Homo sapiens_hsa005110.67794503
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67430390
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67357353
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.65774078
91Hedgehog signaling pathway_Homo sapiens_hsa043400.64884418
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64612742
93Salivary secretion_Homo sapiens_hsa049700.61125682
94Primary immunodeficiency_Homo sapiens_hsa053400.60414613
95Phagosome_Homo sapiens_hsa041450.60191215
96Retinol metabolism_Homo sapiens_hsa008300.60077831
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.59270998
98Axon guidance_Homo sapiens_hsa043600.56538500
99Proteasome_Homo sapiens_hsa030500.56494159
100Fatty acid degradation_Homo sapiens_hsa000710.56075515
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55696090
102Wnt signaling pathway_Homo sapiens_hsa043100.55603378
103Oxytocin signaling pathway_Homo sapiens_hsa049210.54261385
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.54144469
105Ribosome_Homo sapiens_hsa030100.54134573
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54091995
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53761938
108Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52799180
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51378131
110Olfactory transduction_Homo sapiens_hsa047400.51267094
111Fat digestion and absorption_Homo sapiens_hsa049750.50954526
112Glycerolipid metabolism_Homo sapiens_hsa005610.50143421
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49118246
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47521140
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47475025
116Type I diabetes mellitus_Homo sapiens_hsa049400.46613887
117Herpes simplex infection_Homo sapiens_hsa051680.46414992
118Fatty acid metabolism_Homo sapiens_hsa012120.46323843
119Melanoma_Homo sapiens_hsa052180.45872651
120Dopaminergic synapse_Homo sapiens_hsa047280.45806548
121Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45783068
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43953029
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43389533
124Ras signaling pathway_Homo sapiens_hsa040140.42484615
125African trypanosomiasis_Homo sapiens_hsa051430.39457290
126p53 signaling pathway_Homo sapiens_hsa041150.39028541
127Vitamin digestion and absorption_Homo sapiens_hsa049770.38989518
128TNF signaling pathway_Homo sapiens_hsa046680.38888337
129Collecting duct acid secretion_Homo sapiens_hsa049660.38774168
130Nucleotide excision repair_Homo sapiens_hsa034200.38505158
131Amphetamine addiction_Homo sapiens_hsa050310.38409740
132Protein digestion and absorption_Homo sapiens_hsa049740.38358526
133Base excision repair_Homo sapiens_hsa034100.37068849
134Circadian entrainment_Homo sapiens_hsa047130.36513140
135Pyrimidine metabolism_Homo sapiens_hsa002400.36371415
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36304697
137Sulfur relay system_Homo sapiens_hsa041220.36087992
138Leishmaniasis_Homo sapiens_hsa051400.35580058
139Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35190151
140Arginine and proline metabolism_Homo sapiens_hsa003300.35100804
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34448188
142TGF-beta signaling pathway_Homo sapiens_hsa043500.33954762
143Steroid biosynthesis_Homo sapiens_hsa001000.33734801
144Influenza A_Homo sapiens_hsa051640.33664821
145cAMP signaling pathway_Homo sapiens_hsa040240.33636479
146Mineral absorption_Homo sapiens_hsa049780.32867813
147Long-term depression_Homo sapiens_hsa047300.32314335
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.31433187

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