PTGES2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)5.54585669
2lysine catabolic process (GO:0006554)5.54585669
3tricarboxylic acid cycle (GO:0006099)5.42699693
4NADH metabolic process (GO:0006734)5.16400062
5proline biosynthetic process (GO:0006561)5.04852581
6ribosomal small subunit biogenesis (GO:0042274)4.81646343
7negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.69490955
82-oxoglutarate metabolic process (GO:0006103)4.67239643
9fatty acid beta-oxidation (GO:0006635)4.65959438
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.60162134
11aspartate family amino acid catabolic process (GO:0009068)4.52598046
12regulation of translational fidelity (GO:0006450)4.50492555
13respiratory electron transport chain (GO:0022904)4.37909662
14Golgi transport vesicle coating (GO:0048200)4.31380381
15COPI coating of Golgi vesicle (GO:0048205)4.31380381
16regulation of mammary gland epithelial cell proliferation (GO:0033599)4.31366027
17oxidative phosphorylation (GO:0006119)4.31107711
18carnitine shuttle (GO:0006853)4.27878305
19electron transport chain (GO:0022900)4.24840809
20cellular ketone body metabolic process (GO:0046950)4.23129940
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.21426029
22L-phenylalanine metabolic process (GO:0006558)4.19732592
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.19732592
24fatty acid catabolic process (GO:0009062)4.17495541
25fatty acid oxidation (GO:0019395)4.17064561
26acetyl-CoA metabolic process (GO:0006084)4.16099239
27glyoxylate metabolic process (GO:0046487)4.11247543
28lipid oxidation (GO:0034440)4.10823302
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.05614919
30ATP synthesis coupled proton transport (GO:0015986)4.05090305
31energy coupled proton transport, down electrochemical gradient (GO:0015985)4.05090305
32fatty acid transmembrane transport (GO:1902001)4.02556626
33oxaloacetate metabolic process (GO:0006107)3.98207879
34short-chain fatty acid metabolic process (GO:0046459)3.97197609
35regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.95918806
36peptidyl-arginine omega-N-methylation (GO:0035247)3.85554782
37branched-chain amino acid catabolic process (GO:0009083)3.85121676
38monocarboxylic acid catabolic process (GO:0072329)3.77131035
39apoptotic process involved in morphogenesis (GO:0060561)3.71011168
40negative regulation of cell size (GO:0045792)3.69945214
41pentose-phosphate shunt (GO:0006098)3.69759256
42amino-acid betaine metabolic process (GO:0006577)3.69356386
43cysteine metabolic process (GO:0006534)3.69104113
44tricarboxylic acid metabolic process (GO:0072350)3.68285564
45regulation of acyl-CoA biosynthetic process (GO:0050812)3.67599983
46inner mitochondrial membrane organization (GO:0007007)3.67440591
47regulation of sequestering of triglyceride (GO:0010889)3.65480846
48L-phenylalanine catabolic process (GO:0006559)3.62254589
49erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.62254589
50carnitine metabolic process (GO:0009437)3.61999746
51ketone body metabolic process (GO:1902224)3.61909305
52DNA unwinding involved in DNA replication (GO:0006268)3.61341046
53kynurenine metabolic process (GO:0070189)3.61162718
54retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.57179618
55succinate metabolic process (GO:0006105)3.57015152
56sarcomere organization (GO:0045214)3.51563802
57branched-chain amino acid metabolic process (GO:0009081)3.51187360
58protein retention in ER lumen (GO:0006621)3.50796591
59serine family amino acid catabolic process (GO:0009071)3.50294777
60regulation of fatty acid oxidation (GO:0046320)3.49704871
61cell-substrate adherens junction assembly (GO:0007045)3.48787927
62focal adhesion assembly (GO:0048041)3.48787927
63regulation of coenzyme metabolic process (GO:0051196)3.48003180
64regulation of cofactor metabolic process (GO:0051193)3.48003180
65regulation of early endosome to late endosome transport (GO:2000641)3.47646471
66protein maturation by protein folding (GO:0022417)3.47561387
67ethanol oxidation (GO:0006069)3.47278703
68spliceosomal tri-snRNP complex assembly (GO:0000244)3.46646902
69proline metabolic process (GO:0006560)3.45787545
70amino-acid betaine transport (GO:0015838)3.45521989
71carnitine transport (GO:0015879)3.45521989
72biotin metabolic process (GO:0006768)3.44703486
73glucose catabolic process (GO:0006007)3.43198277
74galactose catabolic process (GO:0019388)3.42560201
75sulfur amino acid catabolic process (GO:0000098)3.42197801
76positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.41678321
77nucleobase-containing small molecule interconversion (GO:0015949)3.39188663
78adherens junction assembly (GO:0034333)3.36980191
79ncRNA 3-end processing (GO:0043628)3.36400556
80carnitine transmembrane transport (GO:1902603)3.36220837
81GDP-mannose metabolic process (GO:0019673)3.35187160
82activation of Rac GTPase activity (GO:0032863)3.34798825
83quinone biosynthetic process (GO:1901663)3.31920027
84ubiquinone biosynthetic process (GO:0006744)3.31920027
85alpha-linolenic acid metabolic process (GO:0036109)3.29675195
86NAD metabolic process (GO:0019674)3.28251099
87positive regulation of fatty acid oxidation (GO:0046321)3.28096205
88maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.27825236
89deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.27546144
90protein complex localization (GO:0031503)3.27298290
91mitochondrial fusion (GO:0008053)3.26322898
92carboxylic acid catabolic process (GO:0046395)3.24110215
93organic acid catabolic process (GO:0016054)3.24110215
94aromatic amino acid family catabolic process (GO:0009074)3.22098338
95positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.20212695
96formation of translation preinitiation complex (GO:0001731)3.19449673
97glucose 6-phosphate metabolic process (GO:0051156)3.18959292
98histone arginine methylation (GO:0034969)3.18244391
99protein localization to endosome (GO:0036010)3.16379811
100NADPH regeneration (GO:0006740)3.15382112
101dicarboxylic acid catabolic process (GO:0043649)3.15330031
102quaternary ammonium group transport (GO:0015697)3.14495324
103regulation of glucose import in response to insulin stimulus (GO:2001273)3.13801166
104cellular modified amino acid catabolic process (GO:0042219)3.12522695
105positive regulation of Cdc42 GTPase activity (GO:0043089)3.12030475
106alpha-amino acid catabolic process (GO:1901606)3.11713991
107maternal placenta development (GO:0001893)3.11533475
108mitotic chromosome condensation (GO:0007076)3.10716396
109cellular amino acid catabolic process (GO:0009063)3.09797773
110glycine metabolic process (GO:0006544)3.08740144
111regulation of triglyceride catabolic process (GO:0010896)3.07617190
112regulation of mitochondrial translation (GO:0070129)3.03642497
113coenzyme A biosynthetic process (GO:0015937)3.03131268
114triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.02498295
115coenzyme catabolic process (GO:0009109)3.01981292
116regulation of cholesterol biosynthetic process (GO:0045540)3.01368585
117serine family amino acid metabolic process (GO:0009069)3.01087925
118ventricular cardiac muscle cell action potential (GO:0086005)2.98943939
119indole-containing compound catabolic process (GO:0042436)2.98646411
120indolalkylamine catabolic process (GO:0046218)2.98646411
121tryptophan catabolic process (GO:0006569)2.98646411
122negative regulation of erythrocyte differentiation (GO:0045647)2.97936935
123cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.96784223
124peptidyl-arginine N-methylation (GO:0035246)2.94674257
125peptidyl-arginine methylation (GO:0018216)2.94674257
126positive regulation of fatty acid beta-oxidation (GO:0032000)2.93451392
127ubiquinone metabolic process (GO:0006743)2.92864562
128drug transmembrane transport (GO:0006855)2.92670962
129gluconeogenesis (GO:0006094)2.90980513
130viral transcription (GO:0019083)2.90870734
131coenzyme A metabolic process (GO:0015936)2.90332077
132dicarboxylic acid metabolic process (GO:0043648)2.90329714
133bundle of His cell to Purkinje myocyte communication (GO:0086069)2.89600776
134valine metabolic process (GO:0006573)2.87966482
135aldehyde catabolic process (GO:0046185)2.87264713
136cardiac muscle contraction (GO:0060048)2.87258360
137nucleoside diphosphate biosynthetic process (GO:0009133)2.86863095
138dicarboxylic acid biosynthetic process (GO:0043650)2.85624741
139regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.85602288
140hexose biosynthetic process (GO:0019319)2.81532012
141cellular protein complex localization (GO:0034629)2.81335664
142glutamate metabolic process (GO:0006536)2.81334416
143regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.81230822
144regulation of translational termination (GO:0006449)2.78976820
145ethanol metabolic process (GO:0006067)2.78052002
146ATP biosynthetic process (GO:0006754)2.77629946
147cytoskeletal anchoring at plasma membrane (GO:0007016)2.77257591
148monosaccharide biosynthetic process (GO:0046364)2.76800943
149negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.76684962
150ribonucleoprotein complex biogenesis (GO:0022613)2.75955241
151urea cycle (GO:0000050)2.75280001
152pinocytosis (GO:0006907)2.72902235
153regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.70862630
154glutamine family amino acid biosynthetic process (GO:0009084)2.64754148
155endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.64754073
156mitotic nuclear envelope reassembly (GO:0007084)2.63932566
157nuclear envelope reassembly (GO:0031468)2.63932566
158pentose metabolic process (GO:0019321)2.63342635
159barbed-end actin filament capping (GO:0051016)2.59989797
160rRNA transcription (GO:0009303)2.59873099
161modulation by symbiont of host cellular process (GO:0044068)2.59140829
1623-UTR-mediated mRNA stabilization (GO:0070935)2.59095912
163modulation by virus of host process (GO:0019054)2.58910241
164cell-substrate junction assembly (GO:0007044)2.58307467
165creatine metabolic process (GO:0006600)2.58110327
166glycolytic process (GO:0006096)2.57471217
167translational elongation (GO:0006414)2.56986975
168translational termination (GO:0006415)2.56915590
169mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.55263468
170folic acid metabolic process (GO:0046655)2.54473927
171heterochromatin organization (GO:0070828)2.54302704
172UV protection (GO:0009650)2.53089491
173DNA strand elongation involved in DNA replication (GO:0006271)2.52427107
174DNA strand elongation (GO:0022616)2.51275262
175nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.49157486
176pyrimidine nucleoside salvage (GO:0043097)2.48876865
177pyrimidine-containing compound salvage (GO:0008655)2.48876865
178activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.47956571
179intracellular estrogen receptor signaling pathway (GO:0030520)2.47720712
180negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.47252952
181regulation of glucocorticoid metabolic process (GO:0031943)2.46427486
182desmosome organization (GO:0002934)2.46088344
183adenine nucleotide transport (GO:0051503)2.45058564
184DNA replication initiation (GO:0006270)2.43599884
185regulation of cholesterol homeostasis (GO:2000188)2.43291287
186ribosome biogenesis (GO:0042254)2.42537592
187mitotic G1 DNA damage checkpoint (GO:0031571)2.42528779
188positive regulation of nuclease activity (GO:0032075)2.42514156
189modulation by virus of host morphology or physiology (GO:0019048)2.41731216
190mRNA stabilization (GO:0048255)2.41272063
191RNA stabilization (GO:0043489)2.41272063
192urea metabolic process (GO:0019627)2.39782753

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.59714392
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.31455475
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.27265667
4* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.07922980
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.98661675
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.56718134
7ZNF263_19887448_ChIP-Seq_K562_Human3.26793694
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.25669793
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.04577078
10* LXR_22158963_ChIP-Seq_LIVER_Mouse2.76461339
11MYC_22102868_ChIP-Seq_BL_Human2.59208307
12VDR_21846776_ChIP-Seq_THP-1_Human2.55774614
13E2F7_22180533_ChIP-Seq_HELA_Human2.48279611
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.44979630
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37948588
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.30960331
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20779638
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.06110464
19* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.93008866
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.90594737
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.89849851
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86014563
23HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.82577666
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80899686
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77091573
26LXR_22292898_ChIP-Seq_THP-1_Human1.74455981
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73463912
28STAT3_1855785_ChIP-Seq_MESCs_Mouse1.72082670
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.71447862
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.67269716
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.65792031
32* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65738981
33* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.64113023
34* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.63213042
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.61712660
36KDM2B_26808549_Chip-Seq_DND41_Human1.56948349
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.56929095
38TCF7_22412390_ChIP-Seq_EML_Mouse1.55680432
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55587166
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.54600359
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49626589
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49353647
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.48173495
44PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.47159864
45* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.45946709
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45885751
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.43712200
48CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.42836693
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.42776203
50* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.42060381
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39399680
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.37756624
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36286669
54RACK7_27058665_Chip-Seq_MCF-7_Human1.34511827
55TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.33840477
56CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32824119
57* YY1_22570637_ChIP-Seq_MALME-3M_Human1.32297548
58KDM2B_26808549_Chip-Seq_K562_Human1.31289638
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30352718
60CTCF_27219007_Chip-Seq_Bcells_Human1.30347215
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29263143
62P68_20966046_ChIP-Seq_HELA_Human1.25848470
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.25034536
64CTCF_18555785_ChIP-Seq_MESCs_Mouse1.23095045
65TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22982458
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22107469
67* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.21811818
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21334580
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20886476
70CREB1_26743006_Chip-Seq_LNCaP_Human1.20803164
71* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20772462
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20145576
73BCL6_27268052_Chip-Seq_Bcells_Human1.19888237
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19241230
75E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18430194
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13592250
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13479586
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13425341
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.13304903
80NCOR1_26117541_ChIP-Seq_K562_Human1.12974060
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12811302
82CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12355694
83* FOXP1_21924763_ChIP-Seq_HESCs_Human1.12031047
84ATF3_27146783_Chip-Seq_COLON_Human1.11490122
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11447298
86BCOR_27268052_Chip-Seq_Bcells_Human1.10888130
87RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10299921
88CLOCK_20551151_ChIP-Seq_293T_Human1.09498619
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09156592
90* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.08862963
91* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08642950
92P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08241336
93EGR1_19374776_ChIP-ChIP_THP-1_Human1.08117886
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08001528
95MAF_26560356_Chip-Seq_TH1_Human1.07961622
96GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07702707
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07575562
98MAF_26560356_Chip-Seq_TH2_Human1.07369140
99* CTCF_26484167_Chip-Seq_Bcells_Mouse1.06744513
100VDR_24763502_ChIP-Seq_THP-1_Human1.04174927
101TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03833431
102PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03564752
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03435892
104* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02443738
105E2F1_20622854_ChIP-Seq_HELA_Human1.01560479
106ETS1_21867929_ChIP-Seq_TH2_Mouse0.99975798
107DCP1A_22483619_ChIP-Seq_HELA_Human0.99440588
108ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99003801
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97766400
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96344778
111SMC4_20622854_ChIP-Seq_HELA_Human0.95881429
112DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95821860
113* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95682825
114CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95323510
115UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94639057
116PHF8_20622854_ChIP-Seq_HELA_Human0.94276888
117TBX20_22328084_ChIP-Seq_HEART_Mouse0.94220411
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.94220411
119ELF1_20517297_ChIP-Seq_JURKAT_Human0.93952221
120GABP_19822575_ChIP-Seq_HepG2_Human0.93059057
121KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92370842
122SA1_27219007_Chip-Seq_Bcells_Human0.92302930
123ESR2_21235772_ChIP-Seq_MCF-7_Human0.91327092
124* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89524930
125SPI1_20517297_ChIP-Seq_HL60_Human0.88944308
126CTCF_21964334_Chip-Seq_Bcells_Human0.88549434
127* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88263521
128RAD21_21589869_ChIP-Seq_MESCs_Mouse0.88154628
129OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87892404
130SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87438661
131TAF2_19829295_ChIP-Seq_ESCs_Human0.85558813
132CTCF_21964334_ChIP-Seq_BJAB-B_Human0.84774671
133MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.84549702
134MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.83918004
135* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83116288
136RAC3_21632823_ChIP-Seq_H3396_Human0.82478410
137ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81361604
138GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.81100037
139* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80786590
140TP63_22573176_ChIP-Seq_HFKS_Human0.80713163
141XRN2_22483619_ChIP-Seq_HELA_Human0.80553715
142* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.80000393
143RARA_24833708_ChIP-Seq_LIVER_Mouse0.79900264
144BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.79203592
145SMC3_22415368_ChIP-Seq_MEFs_Mouse0.76968115
146ELK3_25401928_ChIP-Seq_HUVEC_Human0.76934238
147HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76748226

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.61247057
2MP0002837_dystrophic_cardiac_calcinosis4.43839389
3MP0005360_urolithiasis4.38191577
4MP0002139_abnormal_hepatobiliary_system4.18278821
5MP0005085_abnormal_gallbladder_physiolo3.34300794
6MP0005365_abnormal_bile_salt3.31332318
7MP0003195_calcinosis3.28769004
8MP0010234_abnormal_vibrissa_follicle3.27348775
9MP0000751_myopathy3.21883013
10MP0004215_abnormal_myocardial_fiber2.84933029
11MP0003806_abnormal_nucleotide_metabolis2.75942298
12MP0006036_abnormal_mitochondrial_physio2.74757038
13MP0002877_abnormal_melanocyte_morpholog2.73641583
14MP0005330_cardiomyopathy2.71616969
15MP0008875_abnormal_xenobiotic_pharmacok2.52809012
16MP0000749_muscle_degeneration2.51501172
17MP0005332_abnormal_amino_acid2.41221833
18MP0004130_abnormal_muscle_cell2.40363412
19MP0005670_abnormal_white_adipose2.39308693
20MP0004858_abnormal_nervous_system2.38989448
21MP0008260_abnormal_autophagy2.34389438
22MP0004084_abnormal_cardiac_muscle2.33074302
23MP0001849_ear_inflammation2.28265676
24MP0005666_abnormal_adipose_tissue2.19389773
25MP0005076_abnormal_cell_differentiation2.14093132
26MP0009840_abnormal_foam_cell2.13486864
27MP0010329_abnormal_lipoprotein_level2.04722922
28MP0002796_impaired_skin_barrier2.01565059
29MP0000678_abnormal_parathyroid_gland2.00680181
30MP0006035_abnormal_mitochondrial_morpho1.99862233
31MP0002269_muscular_atrophy1.94325172
32MP0003137_abnormal_impulse_conducting1.92482655
33MP0004510_myositis1.92108924
34MP0003693_abnormal_embryo_hatching1.89481935
35MP0004036_abnormal_muscle_relaxation1.88854161
36MP0005083_abnormal_biliary_tract1.85176914
37MP0004087_abnormal_muscle_fiber1.84883853
38MP0004185_abnormal_adipocyte_glucose1.82685161
39MP0003111_abnormal_nucleus_morphology1.81438610
40MP0003221_abnormal_cardiomyocyte_apopto1.75601070
41MP0005501_abnormal_skin_physiology1.73469310
42MP0001348_abnormal_lacrimal_gland1.69673541
43MP0008775_abnormal_heart_ventricle1.67736040
44MP0003453_abnormal_keratinocyte_physiol1.66958196
45MP0002972_abnormal_cardiac_muscle1.66640134
46MP0001730_embryonic_growth_arrest1.64451644
47MP0000747_muscle_weakness1.63001216
48MP0003566_abnormal_cell_adhesion1.62516947
49MP0001666_abnormal_nutrient_absorption1.60846960
50MP0004019_abnormal_vitamin_homeostasis1.60410437
51MP0003252_abnormal_bile_duct1.58709211
52MP0002118_abnormal_lipid_homeostasis1.58158449
53MP0005319_abnormal_enzyme/_coenzyme1.55583050
54MP0000750_abnormal_muscle_regeneration1.55277125
55MP0005620_abnormal_muscle_contractility1.54798124
56MP0009278_abnormal_bone_marrow1.53378599
57MP0002089_abnormal_postnatal_growth/wei1.52844641
58MP0003186_abnormal_redox_activity1.52513225
59MP0004957_abnormal_blastocyst_morpholog1.52165638
60MP0005584_abnormal_enzyme/coenzyme_acti1.49990391
61MP0005451_abnormal_body_composition1.49873434
62MP0000733_abnormal_muscle_development1.49414270
63MP0003656_abnormal_erythrocyte_physiolo1.44117309
64MP0002106_abnormal_muscle_physiology1.43975480
65MP0001873_stomach_inflammation1.43621609
66MP0004484_altered_response_of1.42665614
67MP0001544_abnormal_cardiovascular_syste1.42266328
68MP0005385_cardiovascular_system_phenoty1.42266328
69MP0001661_extended_life_span1.38344957
70MP0000537_abnormal_urethra_morphology1.37248025
71MP0001764_abnormal_homeostasis1.34871859
72MP0004043_abnormal_pH_regulation1.34564062
73MP0009672_abnormal_birth_weight1.34185307
74MP0003123_paternal_imprinting1.33709012
75MP0002249_abnormal_larynx_morphology1.32980838
76MP0010030_abnormal_orbit_morphology1.32843210
77MP0009643_abnormal_urine_homeostasis1.30634016
78MP0005535_abnormal_body_temperature1.29814159
79MP0005375_adipose_tissue_phenotype1.29465221
80MP0009333_abnormal_splenocyte_physiolog1.29124642
81MP0003172_abnormal_lysosome_physiology1.25861335
82MP0000490_abnormal_crypts_of1.23707851
83MP0003329_amyloid_beta_deposits1.23597855
84MP0002971_abnormal_brown_adipose1.22758775
85MP0000759_abnormal_skeletal_muscle1.21887034
86MP0004145_abnormal_muscle_electrophysio1.20694730
87MP0003879_abnormal_hair_cell1.20531190
88MP0003077_abnormal_cell_cycle1.19814964
89MP0000858_altered_metastatic_potential1.19589597
90MP0000609_abnormal_liver_physiology1.19236763
91MP0000350_abnormal_cell_proliferation1.15603583
92MP0010630_abnormal_cardiac_muscle1.11094249
93MP0004947_skin_inflammation1.10404996
94MP0006138_congestive_heart_failure1.10220713
95MP0010094_abnormal_chromosome_stability1.10094618
96MP0002080_prenatal_lethality1.09802613
97MP0002822_catalepsy1.09201431
98MP0008932_abnormal_embryonic_tissue1.08651795
99MP0005623_abnormal_meninges_morphology1.08384960
100MP0005369_muscle_phenotype1.06949663
101MP0002909_abnormal_adrenal_gland1.06285456
102MP0004264_abnormal_extraembryonic_tissu1.05540255
103MP0005257_abnormal_intraocular_pressure1.03856190
104MP0003191_abnormal_cellular_cholesterol1.03744864
105MP0005084_abnormal_gallbladder_morpholo1.00203926
106MP0005165_increased_susceptibility_to0.99700133
107MP0004859_abnormal_synaptic_plasticity0.98550151
108MP0002332_abnormal_exercise_endurance0.98508224
109MP0001346_abnormal_lacrimal_gland0.98206933
110MP0005636_abnormal_mineral_homeostasis0.98046060
111MP0002078_abnormal_glucose_homeostasis0.97319209
112MP0005266_abnormal_metabolism0.96144172
113MP0010352_gastrointestinal_tract_polyps0.91386785
114MP0004085_abnormal_heartbeat0.91255823
115MP0000313_abnormal_cell_death0.91116581
116MP0005621_abnormal_cell_physiology0.90777038
117MP0005334_abnormal_fat_pad0.89147197
118MP0009379_abnormal_foot_pigmentation0.88696067
119MP0002060_abnormal_skin_morphology0.88281781
120MP0002396_abnormal_hematopoietic_system0.87474992
121MP0005409_darkened_coat_color0.87318426
122MP0003705_abnormal_hypodermis_morpholog0.86974894
123MP0004233_abnormal_muscle_weight0.86360486
124MP0000681_abnormal_thyroid_gland0.85886750
125MP0004808_abnormal_hematopoietic_stem0.83965234
126MP0008438_abnormal_cutaneous_collagen0.83352243
127MP0001727_abnormal_embryo_implantation0.82664926
128MP0003984_embryonic_growth_retardation0.82284843
129MP0001672_abnormal_embryogenesis/_devel0.81852266
130MP0005380_embryogenesis_phenotype0.81852266
131MP0008961_abnormal_basal_metabolism0.80532823
132MP0003075_altered_response_to0.80158551
133MP0000579_abnormal_nail_morphology0.79957704
134MP0002138_abnormal_hepatobiliary_system0.79724293
135MP0009931_abnormal_skin_appearance0.78896912
136MP0004147_increased_porphyrin_level0.78607642
137MP0000467_abnormal_esophagus_morphology0.77678289
138MP0000762_abnormal_tongue_morphology0.77237845
139MP0000604_amyloidosis0.75500254
140MP0000230_abnormal_systemic_arterial0.75279052
141MP0001216_abnormal_epidermal_layer0.74884344
142MP0005384_cellular_phenotype0.74340023
143MP0000013_abnormal_adipose_tissue0.74115530
144MP0005376_homeostasis/metabolism_phenot0.73524378
145MP0002088_abnormal_embryonic_growth/wei0.72984944
146MP0001756_abnormal_urination0.71607496
147MP0003011_delayed_dark_adaptation0.70667067
148MP0000462_abnormal_digestive_system0.69103146
149MP0002086_abnormal_extraembryonic_tissu0.68676087
150MP0000343_altered_response_to0.68528488
151MP0008874_decreased_physiological_sensi0.68058231
152MP0000477_abnormal_intestine_morphology0.67627586
153MP0004142_abnormal_muscle_tone0.67097433
154MP0001697_abnormal_embryo_size0.66927420
155MP0003828_pulmonary_edema0.65839086
156MP0001765_abnormal_ion_homeostasis0.64582111
157MP0009642_abnormal_blood_homeostasis0.64454044
158MP0005448_abnormal_energy_balance0.64324666
159MP0002970_abnormal_white_adipose0.60326061
160MP0003953_abnormal_hormone_level0.59473441
161MP0005058_abnormal_lysosome_morphology0.58375809
162MP0002876_abnormal_thyroid_physiology0.57426020
163MP0003567_abnormal_fetal_cardiomyocyte0.56355803
164MP0000598_abnormal_liver_morphology0.55939904
165MP0005452_abnormal_adipose_tissue0.54541742
166MP0000003_abnormal_adipose_tissue0.53042077
167MP0000358_abnormal_cell_content/0.50856298
168MP0003878_abnormal_ear_physiology0.49047108
169MP0005377_hearing/vestibular/ear_phenot0.49047108

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)4.40896885
2Hyperglycinuria (HP:0003108)4.19623619
3Hepatic necrosis (HP:0002605)4.18206317
4Abnormality of fatty-acid metabolism (HP:0004359)4.01102088
5Hyperammonemia (HP:0001987)3.95162271
6Ketosis (HP:0001946)3.88307320
7Ketoacidosis (HP:0001993)3.83886545
8Myoglobinuria (HP:0002913)3.81682038
9Hepatocellular necrosis (HP:0001404)3.79005177
10Distal lower limb muscle weakness (HP:0009053)3.73660524
11Abnormality of glycine metabolism (HP:0010895)3.73591015
12Abnormality of serine family amino acid metabolism (HP:0010894)3.73591015
13Dicarboxylic aciduria (HP:0003215)3.72677503
14Abnormality of dicarboxylic acid metabolism (HP:0010995)3.72677503
15Centrally nucleated skeletal muscle fibers (HP:0003687)3.72313980
16Acute encephalopathy (HP:0006846)3.65449937
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.63214475
18Abnormality of alanine metabolism (HP:0010916)3.63214475
19Hyperalaninemia (HP:0003348)3.63214475
20Hyperacusis (HP:0010780)3.59831492
21Abnormal mitochondria in muscle tissue (HP:0008316)3.57182770
22Cerebral edema (HP:0002181)3.54066849
23Hyperglycinemia (HP:0002154)3.53350067
24Distal lower limb amyotrophy (HP:0008944)3.52082852
25Myopathic facies (HP:0002058)3.49743051
26Rhabdomyolysis (HP:0003201)3.44496083
27Acute necrotizing encephalopathy (HP:0006965)3.40912963
28Achilles tendon contracture (HP:0001771)3.38886041
29Exercise-induced myalgia (HP:0003738)3.36950882
30Hypoglycemic coma (HP:0001325)3.28663768
31Increased connective tissue (HP:0009025)3.27833785
32Lactic acidosis (HP:0003128)3.27433335
33Increased serum pyruvate (HP:0003542)3.26992186
34Abnormality of glycolysis (HP:0004366)3.26992186
35Increased muscle lipid content (HP:0009058)3.24645305
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.22868476
37Mitochondrial inheritance (HP:0001427)3.20490666
38Ventricular tachycardia (HP:0004756)3.20319097
39Lethargy (HP:0001254)3.14564334
40Abnormality of aromatic amino acid family metabolism (HP:0004338)3.09480519
41Palpitations (HP:0001962)3.08426461
42Increased CSF lactate (HP:0002490)3.05835128
43Gout (HP:0001997)3.01019603
44Nausea (HP:0002018)2.99242053
45Metabolic acidosis (HP:0001942)2.94209122
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.88558091
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.88558091
48Abnormality of serum amino acid levels (HP:0003112)2.85911568
49Exercise-induced muscle cramps (HP:0003710)2.84912103
50Increased intramyocellular lipid droplets (HP:0012240)2.78994528
51Xanthomatosis (HP:0000991)2.78837207
52Vertebral compression fractures (HP:0002953)2.73633423
53Increased serum lactate (HP:0002151)2.72668912
54Generalized aminoaciduria (HP:0002909)2.71491713
55Stridor (HP:0010307)2.71132478
56Ragged-red muscle fibers (HP:0003200)2.70432706
57Abnormal gallbladder physiology (HP:0012438)2.68655893
58Cholecystitis (HP:0001082)2.68655893
59Delayed CNS myelination (HP:0002188)2.68311177
60Progressive macrocephaly (HP:0004481)2.64989774
61Muscle fiber inclusion bodies (HP:0100299)2.62811316
62Right ventricular cardiomyopathy (HP:0011663)2.62263923
63Calf muscle hypertrophy (HP:0008981)2.61913898
64Muscle fiber splitting (HP:0003555)2.61193675
65Vomiting (HP:0002013)2.59640712
66Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.59129092
67Nemaline bodies (HP:0003798)2.59091249
68Hypoalphalipoproteinemia (HP:0003233)2.58455798
69Round ear (HP:0100830)2.57508058
70Intrahepatic cholestasis (HP:0001406)2.57384255
71Atrioventricular block (HP:0001678)2.57093208
72CNS demyelination (HP:0007305)2.54895748
73Insomnia (HP:0100785)2.54201309
74Lower limb amyotrophy (HP:0007210)2.52618544
75Abnormality of glutamine family amino acid metabolism (HP:0010902)2.50744596
76Syncope (HP:0001279)2.50733824
77Respiratory failure (HP:0002878)2.49441643
78Trismus (HP:0000211)2.46989283
79Muscle hypertrophy of the lower extremities (HP:0008968)2.44299810
80Lipoatrophy (HP:0100578)2.42789057
81Abnormality of skeletal muscle fiber size (HP:0012084)2.41185537
82Hypolipoproteinemia (HP:0010981)2.40401477
83Dilated cardiomyopathy (HP:0001644)2.40267199
84Upper limb amyotrophy (HP:0009129)2.39261841
85Distal upper limb amyotrophy (HP:0007149)2.39261841
86Type 1 muscle fiber predominance (HP:0003803)2.39120472
87Bulbar palsy (HP:0001283)2.38826072
88Heart block (HP:0012722)2.37902100
89Mildly elevated creatine phosphokinase (HP:0008180)2.37817328
90Increased purine levels (HP:0004368)2.37413347
91Hyperuricemia (HP:0002149)2.37413347
92Atrial fibrillation (HP:0005110)2.35391272
93Methylmalonic aciduria (HP:0012120)2.35020752
94Bundle branch block (HP:0011710)2.34724854
95Abnormal atrioventricular conduction (HP:0005150)2.34512322
96Supraventricular tachycardia (HP:0004755)2.32172547
97Abnormality of the calf musculature (HP:0001430)2.31199912
98Hypobetalipoproteinemia (HP:0003563)2.30972793
99Supraventricular arrhythmia (HP:0005115)2.30689999
100Asymmetric septal hypertrophy (HP:0001670)2.30500354
101Primary atrial arrhythmia (HP:0001692)2.30133122
102Exercise intolerance (HP:0003546)2.29792321
103Reticulocytosis (HP:0001923)2.26019922
104Abnormality of purine metabolism (HP:0004352)2.24391670
105Increased variability in muscle fiber diameter (HP:0003557)2.24109944
106Progressive muscle weakness (HP:0003323)2.23425339
107Proximal tubulopathy (HP:0000114)2.23191796
108Microvesicular hepatic steatosis (HP:0001414)2.23110243
109Ulnar bowing (HP:0003031)2.22829959
110Broad face (HP:0000283)2.19607961
111Abnormality of the Achilles tendon (HP:0005109)2.16330292
112Oligomenorrhea (HP:0000876)2.15395884
113Generalized amyotrophy (HP:0003700)2.12292786
114Ventricular arrhythmia (HP:0004308)2.11545347
115Athetosis (HP:0002305)2.11450059
116Hyperlipoproteinemia (HP:0010980)2.11297913
117Deep venous thrombosis (HP:0002625)2.10911374
118Lipid accumulation in hepatocytes (HP:0006561)2.10777011
119Conjunctival hamartoma (HP:0100780)2.09552246
120Abnormality of urine glucose concentration (HP:0011016)2.08765373
121Glycosuria (HP:0003076)2.08765373
122Abnormality of monocarboxylic acid metabolism (HP:0010996)2.07614241
123Muscle stiffness (HP:0003552)2.06152879
124Late onset (HP:0003584)2.06031491
125Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.04952141
126EMG: myopathic abnormalities (HP:0003458)2.03827460
127Prolonged QT interval (HP:0001657)2.03736236
128Premature rupture of membranes (HP:0001788)2.03684492
129Hyporeflexia of lower limbs (HP:0002600)2.03283261
130Difficulty climbing stairs (HP:0003551)2.01171986
131Pheochromocytoma (HP:0002666)2.00544869
132Progressive external ophthalmoplegia (HP:0000590)2.00331967
133Flat acetabular roof (HP:0003180)1.99925938
134Testicular atrophy (HP:0000029)1.97730418
135Long palpebral fissure (HP:0000637)1.92667089
136Broad distal phalanx of finger (HP:0009836)1.91925744
137Dysmetric saccades (HP:0000641)1.91911208
138Hyperparathyroidism (HP:0000843)1.91692284
139Abnormality of the tricuspid valve (HP:0001702)1.91255438
140Truncus arteriosus (HP:0001660)1.90738123
141Fragile skin (HP:0001030)1.89100947
142Foot dorsiflexor weakness (HP:0009027)1.87957048
143Hyperthyroidism (HP:0000836)1.87888961
144Diaphragmatic weakness (HP:0009113)1.87769289
145Protrusio acetabuli (HP:0003179)1.83978105
146Abnormality of reticulocytes (HP:0004312)1.83754829
147Selective tooth agenesis (HP:0001592)1.81608263
148Neck muscle weakness (HP:0000467)1.81599971
149J-shaped sella turcica (HP:0002680)1.81441232
150Elbow flexion contracture (HP:0002987)1.81366110
151Cholelithiasis (HP:0001081)1.80907493
152Multiple enchondromatosis (HP:0005701)1.80398613
153Hypokinesia (HP:0002375)1.78567827
154Spinal rigidity (HP:0003306)1.78496825
155Cerebral aneurysm (HP:0004944)1.78244413
156Hemorrhage of the eye (HP:0011885)1.77687125
157Metaphyseal cupping (HP:0003021)1.76205345
158Cellulitis (HP:0100658)1.73906517
159Back pain (HP:0003418)1.73499013
160Overriding aorta (HP:0002623)1.73491719
161Axonal loss (HP:0003447)1.72710490
162Abnormality of the umbilical cord (HP:0010881)1.72471889
163Premature skin wrinkling (HP:0100678)1.72449730
164Rough bone trabeculation (HP:0100670)1.70333168
165Colitis (HP:0002583)1.69091293
166Abnormality of the foot musculature (HP:0001436)1.67060425
167Abnormality of the thoracic spine (HP:0100711)1.65920711
168Aplasia/Hypoplasia of the sacrum (HP:0008517)1.65347900
169Patellar dislocation (HP:0002999)1.62496480
170Short nail (HP:0001799)1.62438644
171Obstructive sleep apnea (HP:0002870)1.62362110
172Abnormality of the distal phalanges of the toes (HP:0010182)1.62232014
173Easy fatigability (HP:0003388)1.61919471
174Growth hormone excess (HP:0000845)1.61777581
175Polygenic inheritance (HP:0010982)1.61773483
176Thin bony cortex (HP:0002753)1.60685854
177Pointed chin (HP:0000307)1.60050392
178Elfin facies (HP:0004428)1.59681225
179Hypertensive crisis (HP:0100735)1.56528864
180Spinal cord compression (HP:0002176)1.55232347
181Hand muscle atrophy (HP:0009130)1.55151146
182Cupped ribs (HP:0000887)1.54611811
183Biconcave vertebral bodies (HP:0004586)1.53389318
184Ankle clonus (HP:0011448)1.53333680
185Hypercalcemia (HP:0003072)1.52892312

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.19575303
2TRIB34.21039379
3SMG13.80751722
4IRAK33.14147487
5PHKG13.05627358
6PHKG23.05627358
7PKN22.91044271
8NME22.87750670
9MAPKAPK32.82137697
10TTN2.75768735
11PRPF4B2.63300688
12LMTK22.63008834
13EEF2K2.62366679
14NEK12.58779298
15ICK2.40192518
16PDK42.33407381
17PDK32.33407381
18TLK12.33117050
19OBSCN2.23039820
20PINK12.22172895
21MAP3K112.12777184
22MYLK1.90370684
23NME11.85075543
24TESK21.81197436
25TESK11.68318345
26MAP2K41.64493178
27EPHA41.63730607
28MAP3K101.61659660
29DAPK31.57267725
30MUSK1.49069986
31ARAF1.45545889
32MAPK121.41592779
33TAOK21.39836863
34MAP3K91.36258737
35CDK121.34929729
36WNK41.30475340
37VRK21.29788728
38ABL21.29358209
39MAP3K61.28753206
40RIPK11.28610431
41PRKD31.26677501
42EPHA21.26675669
43PAK41.26142372
44RPS6KB21.24436938
45ILK1.21218756
46PDK21.19624528
47AKT21.15339377
48DAPK11.10970111
49MAP3K51.09215505
50BUB11.07808249
51MST1R1.06762141
52MAPK111.03944042
53PIM21.03582819
54IRAK21.01957202
55SCYL21.01230846
56MINK10.96261949
57MAP3K80.94394083
58PTK60.91842094
59MAP3K130.91090344
60MAP3K120.90425255
61MTOR0.89514189
62DMPK0.88899241
63LATS20.85678045
64EIF2AK10.83104873
65CAMK2D0.82078806
66MARK10.81203146
67CAMK2G0.80375914
68STK38L0.77609914
69PTK20.77389375
70MAP2K70.75939657
71CDK70.74192679
72NEK90.71044072
73BMX0.70887924
74MAP2K60.70773460
75EPHB20.70541805
76PRKAA10.69868008
77MAP3K40.69186161
78DAPK20.69016077
79MAP2K20.68983150
80BRAF0.67575725
81MAP2K10.66532625
82MAP3K70.63557230
83MET0.61478205
84PRKAA20.59952563
85KDR0.59915533
86PRKD20.58397827
87FGFR40.58099778
88CDK40.57814484
89ERN10.57569853
90PRKCI0.57302196
91MAP3K30.57047009
92FLT30.56367489
93MARK20.56211698
94STK380.54830698
95PDPK10.54531334
96RPS6KA20.54048141
97MAP4K10.53720645
98SIK10.53621194
99NTRK10.52782789
100IRAK40.51698380
101CDK80.50700776
102PRKACG0.50309877
103UHMK10.49918898
104RAF10.48714192
105PBK0.48652402
106AURKA0.47813856
107RPS6KC10.47384148
108RPS6KL10.47384148
109MAPK40.47031146
110STK240.45797048
111CAMKK10.45453491
112PRKCZ0.44639704
113CAMK2A0.43488587
114WNK30.42646055
115MAP2K30.41837770
116PRKD10.41572251
117PRKG20.41478431
118TAOK10.41149677
119PRKCG0.40676275
120PDK10.40316493
121CDC70.40188962
122KSR20.39771391
123ROCK10.39383000
124RPS6KA40.38365617
125PAK30.37531151
126BRSK10.37373215
127CDK11A0.37337339
128PRKACA0.37336317
129PAK10.37178520
130PAK20.36860914
131ALK0.36857054
132CDK50.35816130
133STK40.35349058
134TBK10.35239754
135CHEK20.34874427
136SIK20.33521380
137CAMK10.33174438
138LIMK10.32770402
139PAK60.32460748
140CAMK2B0.31764886
141PDGFRA0.31712355
142DYRK20.31227599
143STK110.30497346
144MAP3K10.28316985
145LRRK20.27036473
146CDC42BPA0.26729617
147FER0.26409461

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.03748924
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.80026472
3Fatty acid degradation_Homo sapiens_hsa000713.32873553
4Propanoate metabolism_Homo sapiens_hsa006403.22730567
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.05573841
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.03341588
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.94930682
8Butanoate metabolism_Homo sapiens_hsa006502.60156113
9Oxidative phosphorylation_Homo sapiens_hsa001902.52481156
10Parkinsons disease_Homo sapiens_hsa050122.47635730
11DNA replication_Homo sapiens_hsa030302.47145343
12Fatty acid metabolism_Homo sapiens_hsa012122.46477584
13Carbon metabolism_Homo sapiens_hsa012002.43552205
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28030743
15Pyruvate metabolism_Homo sapiens_hsa006202.27013145
16Other glycan degradation_Homo sapiens_hsa005112.11192216
17Primary bile acid biosynthesis_Homo sapiens_hsa001202.09419488
18Arginine biosynthesis_Homo sapiens_hsa002201.99430142
19Tryptophan metabolism_Homo sapiens_hsa003801.93369475
20beta-Alanine metabolism_Homo sapiens_hsa004101.90572487
21Peroxisome_Homo sapiens_hsa041461.88940323
22Cardiac muscle contraction_Homo sapiens_hsa042601.86994601
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.85797067
24Sulfur relay system_Homo sapiens_hsa041221.77580351
25PPAR signaling pathway_Homo sapiens_hsa033201.72588940
26Base excision repair_Homo sapiens_hsa034101.71365836
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.67805277
28Alzheimers disease_Homo sapiens_hsa050101.64800023
29Nitrogen metabolism_Homo sapiens_hsa009101.60697323
30Biosynthesis of amino acids_Homo sapiens_hsa012301.56293290
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53099309
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.52186530
33Chronic myeloid leukemia_Homo sapiens_hsa052201.51374162
34Huntingtons disease_Homo sapiens_hsa050161.49826343
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.46213779
36Acute myeloid leukemia_Homo sapiens_hsa052211.42349097
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.41674501
38Non-small cell lung cancer_Homo sapiens_hsa052231.41582170
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.37923620
40Thyroid cancer_Homo sapiens_hsa052161.28775565
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27971478
42VEGF signaling pathway_Homo sapiens_hsa043701.20850816
43Sulfur metabolism_Homo sapiens_hsa009201.20011600
44Fatty acid elongation_Homo sapiens_hsa000621.19522318
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19434643
46Folate biosynthesis_Homo sapiens_hsa007901.18719056
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16894923
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16631628
49Fat digestion and absorption_Homo sapiens_hsa049751.14852626
50Starch and sucrose metabolism_Homo sapiens_hsa005001.12517045
51Arginine and proline metabolism_Homo sapiens_hsa003301.12050752
52Pentose phosphate pathway_Homo sapiens_hsa000301.11147039
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.07957951
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.07143305
55Fructose and mannose metabolism_Homo sapiens_hsa000511.06529291
56Pancreatic cancer_Homo sapiens_hsa052121.06016414
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.02588781
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.96074672
59Glioma_Homo sapiens_hsa052140.95609166
60Fatty acid biosynthesis_Homo sapiens_hsa000610.94880228
61Endometrial cancer_Homo sapiens_hsa052130.94832373
62Galactose metabolism_Homo sapiens_hsa000520.93728682
63Bile secretion_Homo sapiens_hsa049760.92236040
64Notch signaling pathway_Homo sapiens_hsa043300.90803619
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89755601
66Vibrio cholerae infection_Homo sapiens_hsa051100.89406577
67Phenylalanine metabolism_Homo sapiens_hsa003600.86639357
68Spliceosome_Homo sapiens_hsa030400.85561585
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84616014
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83338726
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81984876
72Histidine metabolism_Homo sapiens_hsa003400.81389933
73Mismatch repair_Homo sapiens_hsa034300.81136501
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.78958039
75Glutathione metabolism_Homo sapiens_hsa004800.78050850
76N-Glycan biosynthesis_Homo sapiens_hsa005100.76152426
77mTOR signaling pathway_Homo sapiens_hsa041500.75128010
78B cell receptor signaling pathway_Homo sapiens_hsa046620.73252978
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72959520
80* Metabolic pathways_Homo sapiens_hsa011000.72584958
81Selenocompound metabolism_Homo sapiens_hsa004500.70994318
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.70222615
83ErbB signaling pathway_Homo sapiens_hsa040120.69523624
84Glycerolipid metabolism_Homo sapiens_hsa005610.69253304
85Viral carcinogenesis_Homo sapiens_hsa052030.68798587
86Proteasome_Homo sapiens_hsa030500.66421072
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64691384
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64381398
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64025201
90Small cell lung cancer_Homo sapiens_hsa052220.63291602
91Dilated cardiomyopathy_Homo sapiens_hsa054140.61880604
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.60806467
93Chemical carcinogenesis_Homo sapiens_hsa052040.60284696
94Cell cycle_Homo sapiens_hsa041100.60263554
95Apoptosis_Homo sapiens_hsa042100.60233266
96Tyrosine metabolism_Homo sapiens_hsa003500.59826171
97Long-term potentiation_Homo sapiens_hsa047200.56169859
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55817906
99Renal cell carcinoma_Homo sapiens_hsa052110.54401638
100Vitamin digestion and absorption_Homo sapiens_hsa049770.54377361
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53701010
102Shigellosis_Homo sapiens_hsa051310.52082195
103GnRH signaling pathway_Homo sapiens_hsa049120.51911244
104HTLV-I infection_Homo sapiens_hsa051660.51611260
105Complement and coagulation cascades_Homo sapiens_hsa046100.50626743
106HIF-1 signaling pathway_Homo sapiens_hsa040660.49255011
107Retinol metabolism_Homo sapiens_hsa008300.49082909
108Lysosome_Homo sapiens_hsa041420.47982461
109mRNA surveillance pathway_Homo sapiens_hsa030150.47564613
110Insulin signaling pathway_Homo sapiens_hsa049100.46758286
111Hepatitis C_Homo sapiens_hsa051600.46483325
112Nucleotide excision repair_Homo sapiens_hsa034200.46441146
113Proteoglycans in cancer_Homo sapiens_hsa052050.45275129
114Colorectal cancer_Homo sapiens_hsa052100.44846453
115Endocytosis_Homo sapiens_hsa041440.44571314
116Alcoholism_Homo sapiens_hsa050340.41695791
117Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41549311
118Inositol phosphate metabolism_Homo sapiens_hsa005620.41334800
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40303591
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39672984
121Glucagon signaling pathway_Homo sapiens_hsa049220.39020941
122Epstein-Barr virus infection_Homo sapiens_hsa051690.38605376
123Focal adhesion_Homo sapiens_hsa045100.38328856
124AMPK signaling pathway_Homo sapiens_hsa041520.36217183
125Hepatitis B_Homo sapiens_hsa051610.35693275
126Insulin resistance_Homo sapiens_hsa049310.35294076
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34582167
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.34483704
129ABC transporters_Homo sapiens_hsa020100.33842552
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.33642356
131Estrogen signaling pathway_Homo sapiens_hsa049150.33622198
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33136129
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31896957
134Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30945377
135Lysine degradation_Homo sapiens_hsa003100.30752801
136Vitamin B6 metabolism_Homo sapiens_hsa007500.25878809
137Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.25461286
138Ribosome_Homo sapiens_hsa030100.22406456
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.22402303
140Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16714523
141Synaptic vesicle cycle_Homo sapiens_hsa047210.16473359
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.15937697
143Prion diseases_Homo sapiens_hsa050200.14706702
144Regulation of autophagy_Homo sapiens_hsa041400.14444110
145Pyrimidine metabolism_Homo sapiens_hsa002400.14413946
146Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12677368
147One carbon pool by folate_Homo sapiens_hsa006700.09333274
148Collecting duct acid secretion_Homo sapiens_hsa049660.08872806
149Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08572055
150Central carbon metabolism in cancer_Homo sapiens_hsa052300.04144669
151Bladder cancer_Homo sapiens_hsa052190.03913225
152Steroid biosynthesis_Homo sapiens_hsa001000.03363730
153Longevity regulating pathway - mammal_Homo sapiens_hsa042110.00563163
154Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0164478
155Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0001830

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