PTGER4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NIK/NF-kappaB signaling (GO:0038061)6.01374589
2antigen processing and presentation of endogenous antigen (GO:0019883)5.53335000
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.52295230
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.52295230
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.37809003
6positive regulation of gamma-delta T cell activation (GO:0046645)5.16176274
7regulation of interleukin-12 biosynthetic process (GO:0045075)4.72313232
8myeloid dendritic cell differentiation (GO:0043011)4.43558165
9myeloid dendritic cell activation (GO:0001773)4.37634372
10response to muramyl dipeptide (GO:0032495)4.22096537
11positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.20982394
12negative thymic T cell selection (GO:0045060)4.19655200
13neutrophil activation involved in immune response (GO:0002283)4.13302023
14negative T cell selection (GO:0043383)4.08184686
15positive regulation of natural killer cell differentiation (GO:0032825)4.00470956
16negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.98601769
17positive T cell selection (GO:0043368)3.92548636
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.77687315
19regulation of gamma-delta T cell activation (GO:0046643)3.76042978
20regulation of alpha-beta T cell proliferation (GO:0046640)3.69360519
21regulation of gamma-delta T cell differentiation (GO:0045586)3.69175723
22positive regulation of interleukin-2 production (GO:0032743)3.68420901
23positive regulation of antigen processing and presentation (GO:0002579)3.63172035
24positive regulation of granulocyte differentiation (GO:0030854)3.62564515
25interferon-gamma-mediated signaling pathway (GO:0060333)3.61798834
26neutrophil activation (GO:0042119)3.61699409
27regulation of T-helper 1 cell differentiation (GO:0045625)3.56382995
28regulation of dendritic cell antigen processing and presentation (GO:0002604)3.53868204
29dendritic cell differentiation (GO:0097028)3.50847037
30negative regulation of T cell mediated immunity (GO:0002710)3.50832996
31negative regulation of interleukin-12 production (GO:0032695)3.49917935
32granulocyte activation (GO:0036230)3.47029398
33T cell migration (GO:0072678)3.44823582
34positive regulation of alpha-beta T cell proliferation (GO:0046641)3.43828689
35positive regulation of tolerance induction (GO:0002645)3.43741361
36regulation of T cell tolerance induction (GO:0002664)3.42541726
37JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.42320613
38positive regulation of humoral immune response (GO:0002922)3.39994071
39response to type I interferon (GO:0034340)3.39114690
40type I interferon signaling pathway (GO:0060337)3.38664859
41cellular response to type I interferon (GO:0071357)3.38664859
42positive regulation of interleukin-12 production (GO:0032735)3.36806605
43immunoglobulin mediated immune response (GO:0016064)3.35448495
44positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.33718773
45positive regulation of B cell differentiation (GO:0045579)3.32064529
46regulation of RIG-I signaling pathway (GO:0039535)3.29329566
47cellular extravasation (GO:0045123)3.28654058
48regulation of antigen processing and presentation (GO:0002577)3.28209745
49regulation of isotype switching to IgG isotypes (GO:0048302)3.26003316
50thymic T cell selection (GO:0045061)3.24923441
51regulation of germinal center formation (GO:0002634)3.23585941
52regulation of regulatory T cell differentiation (GO:0045589)3.22819915
53negative regulation of erythrocyte differentiation (GO:0045647)3.22738028
54tolerance induction (GO:0002507)3.21388780
55response to interleukin-15 (GO:0070672)3.21262585
56regulation of B cell receptor signaling pathway (GO:0050855)3.20457624
57response to peptidoglycan (GO:0032494)3.17239773
58positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.16555516
59leukocyte aggregation (GO:0070486)3.16203637
60natural killer cell mediated immunity (GO:0002228)3.14824023
61natural killer cell mediated cytotoxicity (GO:0042267)3.14824023
62negative regulation of bone resorption (GO:0045779)3.14695530
63interferon-gamma production (GO:0032609)3.14479947
64natural killer cell differentiation (GO:0001779)3.10562207
65regulation of hypersensitivity (GO:0002883)3.10116942
66T cell selection (GO:0045058)3.09712869
67positive regulation of interferon-alpha production (GO:0032727)3.09053426
68cellular response to interleukin-15 (GO:0071350)3.08056822
69regulation of B cell differentiation (GO:0045577)3.07928224
70negative regulation of lymphocyte mediated immunity (GO:0002707)3.07512991
71negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.06849763
72regulation of tolerance induction (GO:0002643)3.06788980
73regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.06700514
74negative regulation of interleukin-1 beta production (GO:0032691)3.06160561
75negative regulation of innate immune response (GO:0045824)3.05678978
76mature B cell differentiation (GO:0002335)3.02762474
77regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.02187170
78regulation of interleukin-2 biosynthetic process (GO:0045076)3.02122421
79regulation of interleukin-12 production (GO:0032655)3.02036561
80positive regulation of isotype switching (GO:0045830)3.01200269
81regulation of alpha-beta T cell activation (GO:0046634)3.00836479
82negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.00193359
83negative regulation of T-helper cell differentiation (GO:0045623)3.00193359
84germinal center formation (GO:0002467)2.99907699
85negative regulation of cell killing (GO:0031342)2.99784844
86negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.99784844
87negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.99604005
88response to protozoan (GO:0001562)2.99046350
89regulation of interferon-alpha production (GO:0032647)2.98921050
90positive thymic T cell selection (GO:0045059)2.98153104
91T-helper 1 type immune response (GO:0042088)2.98107454
92cellular response to interferon-beta (GO:0035458)2.98069846
93natural killer cell activation (GO:0030101)2.98011670
94growth hormone receptor signaling pathway (GO:0060396)2.96088565
95antigen processing and presentation via MHC class Ib (GO:0002475)2.95877165
96positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.95474196
97regulation of T cell mediated cytotoxicity (GO:0001914)2.95048130
98regulation of necroptotic process (GO:0060544)2.95045384
99positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.94773244
100positive regulation of T cell cytokine production (GO:0002726)2.94628804
101positive regulation by symbiont of host defense response (GO:0052509)2.94274519
102modulation by symbiont of host defense response (GO:0052031)2.94274519
103modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.94274519
104modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.94274519
105positive regulation by organism of defense response of other organism involved in symbiotic interact2.94274519
106modulation by symbiont of host immune response (GO:0052553)2.94274519
107hepatocyte apoptotic process (GO:0097284)2.92883493
108detection of other organism (GO:0098543)2.92576100
109regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.92287902
110positive regulation of alpha-beta T cell differentiation (GO:0046638)2.91905253
111regulation of alpha-beta T cell differentiation (GO:0046637)2.91624927
112B cell mediated immunity (GO:0019724)2.90075937
113mature B cell differentiation involved in immune response (GO:0002313)2.90056068
114B cell receptor signaling pathway (GO:0050853)2.89570099
115mast cell activation (GO:0045576)2.89303937
116defense response to protozoan (GO:0042832)2.88371188
117lymphocyte migration (GO:0072676)2.87320587
118regulation of granulocyte differentiation (GO:0030852)2.87021315
119regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.86765326
120* CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.86519850
121* T-helper cell differentiation (GO:0042093)2.86519850
122lipopolysaccharide-mediated signaling pathway (GO:0031663)2.86128830
123negative regulation of interleukin-6 production (GO:0032715)2.86013321
124regulation of interleukin-2 production (GO:0032663)2.85832043
125regulation of immunoglobulin secretion (GO:0051023)2.84946839
126mucosal-associated lymphoid tissue development (GO:0048537)2.84768006
127Peyers patch development (GO:0048541)2.84768006
128negative regulation of leukocyte mediated immunity (GO:0002704)2.84624242
129regulation of response to interferon-gamma (GO:0060330)2.84516623
130T cell receptor signaling pathway (GO:0050852)2.84254152
131* alpha-beta T cell differentiation (GO:0046632)2.84155602
132positive regulation of alpha-beta T cell activation (GO:0046635)2.83919590
133regulation of T cell receptor signaling pathway (GO:0050856)2.83768861
134Arp2/3 complex-mediated actin nucleation (GO:0034314)2.83517630
135response to interferon-beta (GO:0035456)2.82142423
136positive regulation of macrophage differentiation (GO:0045651)2.81660649
137regulation of chronic inflammatory response (GO:0002676)2.81435344
138regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.80081497

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.88735817
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.85751050
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.62416486
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.36224581
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.14704136
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.89366772
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.68887326
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.68389905
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.40123387
10* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.40027280
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.31507679
12IRF8_27001747_Chip-Seq_BMDM_Mouse3.22655388
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.16203900
14* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.93844145
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.89011661
16* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.86116805
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.85260967
18* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.84151259
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.83538051
20RUNX_20019798_ChIP-Seq_JUKART_Human2.68625738
21* MYB_26560356_Chip-Seq_TH2_Human2.52526558
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.37295292
23SCL_19346495_ChIP-Seq_HPC-7_Human2.36732416
24* MAF_26560356_Chip-Seq_TH1_Human2.34007510
25* SPI1_23547873_ChIP-Seq_NB4_Human2.13862300
26E2F7_22180533_ChIP-Seq_HELA_Human2.12433764
27* MYB_26560356_Chip-Seq_TH1_Human2.10990389
28* VDR_21846776_ChIP-Seq_THP-1_Human2.08303677
29MYC_22102868_ChIP-Seq_BL_Human2.07562725
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.03711357
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.97261779
32* VDR_24763502_ChIP-Seq_THP-1_Human1.94577224
33* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.94037786
34* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92492475
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91831426
36* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87378294
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.79432680
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.78144540
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.76872553
40UTX_26944678_Chip-Seq_JUKART_Human1.73486597
41* TCF7_22412390_ChIP-Seq_EML_Mouse1.73408535
42GATA3_27048872_Chip-Seq_THYMUS_Human1.57011883
43PU_27001747_Chip-Seq_BMDM_Mouse1.55547179
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55492819
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.49697424
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47895352
47SPI1_23127762_ChIP-Seq_K562_Human1.44904543
48* VDR_24787735_ChIP-Seq_THP-1_Human1.43220779
49MAF_26560356_Chip-Seq_TH2_Human1.42010134
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39936688
51GATA1_22025678_ChIP-Seq_K562_Human1.38257746
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36167365
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35471260
54* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33907961
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32547000
56* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27771876
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26842665
58* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26079831
59* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24820143
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24442085
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24391787
62* ELK3_25401928_ChIP-Seq_HUVEC_Human1.20494799
63GATA3_26560356_Chip-Seq_TH2_Human1.19368281
64* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17740324
65* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17699032
66* KDM2B_26808549_Chip-Seq_DND41_Human1.15659028
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15371257
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13471379
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11332614
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09653820
71* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09149665
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04304251
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03987700
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.02462019
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.02462019
76KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.02462019
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01741840
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01571921
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01401214
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00408792
81GATA2_21666600_ChIP-Seq_HMVEC_Human0.99845677
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95590206
83SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95590206
84ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93597390
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93344970
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92600418
87GATA1_19941827_ChIP-Seq_MEL_Mouse0.90290914
88SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89512161
89SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87889464
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87862271
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86531879
92ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85714461
93BCL6_27268052_Chip-Seq_Bcells_Human0.85145659
94CIITA_25753668_ChIP-Seq_RAJI_Human0.84383527
95* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82719771
96STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82324672
97EGR1_19032775_ChIP-ChIP_M12_Human0.81879653
98* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81019782
99* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80255819
100RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79720811
101* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79120823
102SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.77611807
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76031012
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.75743613
105NCOR1_26117541_ChIP-Seq_K562_Human0.74333419
106HOXB4_20404135_ChIP-ChIP_EML_Mouse0.74189162
107FOXO3_23340844_ChIP-Seq_DLD1_Human0.72113794
108BCOR_27268052_Chip-Seq_Bcells_Human0.71174544
109PU.1_20513432_ChIP-Seq_Bcells_Mouse0.71041904
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70946176
111GATA2_19941826_ChIP-Seq_K562_Human0.70245894
112RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.69286316
113KDM2B_26808549_Chip-Seq_JURKAT_Human0.68822389
114GATA1_19941826_ChIP-Seq_K562_Human0.67343823
115RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.64753253

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.46171524
2MP0000685_abnormal_immune_system3.86048480
3MP0005671_abnormal_response_to3.41145829
4MP0009785_altered_susceptibility_to3.17150940
5MP0005387_immune_system_phenotype3.11646232
6MP0001790_abnormal_immune_system3.11646232
7* MP0002148_abnormal_hypersensitivity_rea3.03691387
8* MP0003436_decreased_susceptibility_to3.03305572
9* MP0005000_abnormal_immune_tolerance2.96247931
10MP0004510_myositis2.93245033
11MP0001800_abnormal_humoral_immune2.91450327
12MP0002254_reproductive_system_inflammat2.89200712
13MP0002138_abnormal_hepatobiliary_system2.77450958
14* MP0002452_abnormal_antigen_presenting2.69580543
15* MP0002723_abnormal_immune_serum2.63501569
16MP0005025_abnormal_response_to2.61580883
17* MP0002166_altered_tumor_susceptibility2.54799998
18MP0003763_abnormal_thymus_physiology2.49630929
19* MP0001819_abnormal_immune_cell2.47419822
20* MP0002420_abnormal_adaptive_immunity2.46634275
21* MP0002419_abnormal_innate_immunity2.44086229
22MP0003303_peritoneal_inflammation2.27625622
23* MP0002006_tumorigenesis2.25898744
24MP0001873_stomach_inflammation2.24443492
25MP0004947_skin_inflammation2.15000556
26MP0002405_respiratory_system_inflammati2.14086870
27* MP0002398_abnormal_bone_marrow2.10469522
28MP0010155_abnormal_intestine_physiology2.02420775
29* MP0000716_abnormal_immune_system1.99865549
30MP0006082_CNS_inflammation1.99126051
31MP0003300_gastrointestinal_ulcer1.96513662
32MP0001853_heart_inflammation1.96354787
33MP0002396_abnormal_hematopoietic_system1.93998205
34MP0005310_abnormal_salivary_gland1.90626209
35MP0003724_increased_susceptibility_to1.90582434
36MP0005464_abnormal_platelet_physiology1.73991557
37MP0009333_abnormal_splenocyte_physiolog1.72621907
38MP0001845_abnormal_inflammatory_respons1.72075210
39MP0000689_abnormal_spleen_morphology1.67796271
40MP0002722_abnormal_immune_system1.67583250
41MP0001348_abnormal_lacrimal_gland1.66172307
42* MP0002429_abnormal_blood_cell1.62773327
43MP0002163_abnormal_gland_morphology1.59297150
44MP0005397_hematopoietic_system_phenotyp1.54919799
45MP0001545_abnormal_hematopoietic_system1.54919799
46MP0003866_abnormal_defecation1.49402710
47MP0004808_abnormal_hematopoietic_stem1.47326769
48MP0003448_altered_tumor_morphology1.43241750
49MP0002277_abnormal_respiratory_mucosa1.43160072
50MP0000703_abnormal_thymus_morphology1.40143270
51* MP0001533_abnormal_skeleton_physiology1.39550327
52MP0010352_gastrointestinal_tract_polyps1.38190734
53MP0002877_abnormal_melanocyte_morpholog1.36923279
54MP0000858_altered_metastatic_potential1.29402445
55* MP0008469_abnormal_protein_level1.28525842
56MP0009764_decreased_sensitivity_to1.26526376
57MP0005174_abnormal_tail_pigmentation1.26058123
58MP0005076_abnormal_cell_differentiation1.24742618
59MP0000569_abnormal_digit_pigmentation1.24610993
60MP0003656_abnormal_erythrocyte_physiolo1.20376343
61MP0009278_abnormal_bone_marrow1.17502985
62MP0000490_abnormal_crypts_of1.14007743
63MP0005166_decreased_susceptibility_to1.13562258
64MP0003453_abnormal_keratinocyte_physiol1.11856640
65* MP0002998_abnormal_bone_remodeling1.00107265
66MP0004381_abnormal_hair_follicle0.99655923
67* MP0002933_joint_inflammation0.99477936
68MP0008057_abnormal_DNA_replication0.98364384
69MP0000465_gastrointestinal_hemorrhage0.97177014
70MP0003091_abnormal_cell_migration0.85549824
71MP0001663_abnormal_digestive_system0.85432625
72MP0001501_abnormal_sleep_pattern0.85018554
73MP0001851_eye_inflammation0.83537520
74* MP0002009_preneoplasia0.83285543
75MP0001346_abnormal_lacrimal_gland0.82786573
76MP0009765_abnormal_xenobiotic_induced0.81667543
77MP0004883_abnormal_blood_vessel0.78851678
78MP0003566_abnormal_cell_adhesion0.78438940
79MP0005451_abnormal_body_composition0.76655706
80MP0001881_abnormal_mammary_gland0.76583412
81MP0008961_abnormal_basal_metabolism0.75005290
82MP0000343_altered_response_to0.74966114
83MP0001216_abnormal_epidermal_layer0.74550981
84MP0005164_abnormal_response_to0.74307003
85MP0005058_abnormal_lysosome_morphology0.74176539
86MP0003828_pulmonary_edema0.74027697
87MP0008004_abnormal_stomach_pH0.73212972
88* MP0002019_abnormal_tumor_incidence0.70786611
89MP0009763_increased_sensitivity_to0.69177483
90* MP0005390_skeleton_phenotype0.67964920
91MP0000604_amyloidosis0.67168177
92MP0002132_abnormal_respiratory_system0.66209122
93MP0000627_abnormal_mammary_gland0.66088984
94MP0000371_diluted_coat_color0.65528101
95MP0002136_abnormal_kidney_physiology0.64479439
96MP0009840_abnormal_foam_cell0.63976138
97MP0003191_abnormal_cellular_cholesterol0.63831579
98* MP0000249_abnormal_blood_vessel0.63819478
99MP0001191_abnormal_skin_condition0.63105495
100MP0008260_abnormal_autophagy0.62790118
101MP0005167_abnormal_blood-brain_barrier0.62522410
102MP0000767_abnormal_smooth_muscle0.61867831
103MP0001243_abnormal_dermal_layer0.61077172
104MP0003075_altered_response_to0.60444366
105MP0003172_abnormal_lysosome_physiology0.59579421
106MP0010307_abnormal_tumor_latency0.58484276
107MP0003183_abnormal_peptide_metabolism0.58250592
108MP0005379_endocrine/exocrine_gland_phen0.57971916
109MP0002095_abnormal_skin_pigmentation0.57814860
110MP0005075_abnormal_melanosome_morpholog0.56908390
111MP0004130_abnormal_muscle_cell0.55326693
112MP0001919_abnormal_reproductive_system0.54869194
113MP0008007_abnormal_cellular_replicative0.54772097
114* MP0003795_abnormal_bone_structure0.54751240
115* MP0000609_abnormal_liver_physiology0.54171273
116MP0002693_abnormal_pancreas_physiology0.53252908
117MP0003045_fibrosis0.51714602
118MP0001542_abnormal_bone_strength0.51313827
119MP0005023_abnormal_wound_healing0.51073268
120MP0003690_abnormal_glial_cell0.50997383
121MP0003279_aneurysm0.50583100
122MP0005535_abnormal_body_temperature0.49027745

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)5.02911818
2Eczematoid dermatitis (HP:0000976)4.90984703
3Recurrent abscess formation (HP:0002722)4.84190335
4Recurrent fungal infections (HP:0002841)4.67648006
5Recurrent bacterial skin infections (HP:0005406)4.64531758
6Elevated erythrocyte sedimentation rate (HP:0003565)4.64467168
7Optic neuritis (HP:0100653)4.62028295
8Retrobulbar optic neuritis (HP:0100654)4.62028295
9Orchitis (HP:0100796)4.58197980
10Recurrent viral infections (HP:0004429)4.46288085
11Chronic otitis media (HP:0000389)4.45292767
12Autoimmune thrombocytopenia (HP:0001973)4.20758750
13Thrombocytosis (HP:0001894)3.81922236
14Mediastinal lymphadenopathy (HP:0100721)3.75827024
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.69635625
16Vasculitis (HP:0002633)3.66969207
17Nasal polyposis (HP:0100582)3.54858348
18Arterial thrombosis (HP:0004420)3.53870274
19Increased IgM level (HP:0003496)3.51151860
20Abnormality of macrophages (HP:0004311)3.41589288
21Recurrent cutaneous fungal infections (HP:0011370)3.40838839
22Chronic mucocutaneous candidiasis (HP:0002728)3.40838839
23Recurrent skin infections (HP:0001581)3.39841626
24Abnormality of T cell number (HP:0011839)3.39652367
25Gastrointestinal infarctions (HP:0005244)3.27865919
26Pulmonary infiltrates (HP:0002113)3.25612122
27Eosinophilia (HP:0001880)3.21282421
28Abnormality of the nasal mucosa (HP:0000433)3.18701117
29Stomach cancer (HP:0012126)3.18282385
30Recurrent bronchitis (HP:0002837)3.12036698
31Fatigue (HP:0012378)3.11853317
32Leukocytosis (HP:0001974)3.11633724
33Stomatitis (HP:0010280)3.06484042
34Periodontitis (HP:0000704)3.06397513
35Abnormality of T cells (HP:0002843)3.05456537
36Panhypogammaglobulinemia (HP:0003139)3.04951374
37Abnormality of T cell physiology (HP:0011840)3.00985358
38T lymphocytopenia (HP:0005403)2.99781559
39Autoimmune hemolytic anemia (HP:0001890)2.98730151
40Increased IgE level (HP:0003212)2.98566547
41Pustule (HP:0200039)2.98219232
42Meningitis (HP:0001287)2.97986339
43IgM deficiency (HP:0002850)2.91661022
44Agammaglobulinemia (HP:0004432)2.89149613
45Keratoconjunctivitis sicca (HP:0001097)2.87491114
46Granulocytopenia (HP:0001913)2.87135900
47Hypergammaglobulinemia (HP:0010702)2.85589475
48Recurrent gram-negative bacterial infections (HP:0005420)2.85169393
49Cellulitis (HP:0100658)2.79969767
50Hemoptysis (HP:0002105)2.75409735
51Abnormality of eosinophils (HP:0001879)2.74746117
52Inflammation of the large intestine (HP:0002037)2.74240112
53Chronic obstructive pulmonary disease (HP:0006510)2.72375868
54Obstructive lung disease (HP:0006536)2.72375868
55Colitis (HP:0002583)2.67228589
56Chronic diarrhea (HP:0002028)2.65511686
57Spontaneous hematomas (HP:0007420)2.64343203
58Hematochezia (HP:0002573)2.63300311
59Gastrointestinal inflammation (HP:0004386)2.63222046
60Myocardial infarction (HP:0001658)2.62918205
61Keratoconjunctivitis (HP:0001096)2.62192164
62Dysostosis multiplex (HP:0000943)2.58935612
63Severe combined immunodeficiency (HP:0004430)2.58123013
64Thyroiditis (HP:0100646)2.55667027
65Gingivitis (HP:0000230)2.53104989
66Abnormality of the fingertips (HP:0001211)2.52695281
67Encephalitis (HP:0002383)2.52235355
68Abnormality of cells of the lymphoid lineage (HP:0012140)2.48720985
69Pulmonary embolism (HP:0002204)2.47519463
70Abnormality of B cell number (HP:0010975)2.47452635
71B lymphocytopenia (HP:0010976)2.47452635
72Gingival bleeding (HP:0000225)2.47338199
73Chest pain (HP:0100749)2.47288220
74Abnormality of liposaccharide metabolism (HP:0010968)2.46608986
75Abnormality of glycosphingolipid metabolism (HP:0004343)2.46608986
76Abnormality of glycolipid metabolism (HP:0010969)2.46608986
77IgG deficiency (HP:0004315)2.43305002
78Interstitial pulmonary disease (HP:0006530)2.43245291
79IgA deficiency (HP:0002720)2.38613292
80Lymphopenia (HP:0001888)2.37423161
81Petechiae (HP:0000967)2.36392291
82Increased cerebral lipofuscin (HP:0011813)2.33376754
83Combined immunodeficiency (HP:0005387)2.30975014
84Osteolytic defects of the phalanges of the hand (HP:0009771)2.30752331
85Osteolytic defects of the hand bones (HP:0009699)2.30752331
86Epistaxis (HP:0000421)2.28566082
87Amaurosis fugax (HP:0100576)2.28430427
88Glomerulopathy (HP:0100820)2.26005448
89Peritonitis (HP:0002586)2.25948059
90Vacuolated lymphocytes (HP:0001922)2.25491426
91Basal ganglia calcification (HP:0002135)2.21308796
92Prostate neoplasm (HP:0100787)2.20988083
93Polycythemia (HP:0001901)2.17712420
94Joint swelling (HP:0001386)2.16931349
95Verrucae (HP:0200043)2.16728537
96Papilloma (HP:0012740)2.16728537
97Skin ulcer (HP:0200042)2.15632525
98Gastrointestinal stroma tumor (HP:0100723)2.14900719
99Episodic fever (HP:0001954)2.11845162
100Amyloidosis (HP:0011034)2.09521938
101Increased neuronal autofluorescent lipopigment (HP:0002074)2.09431495
102Osteomyelitis (HP:0002754)2.08786174
103Abnormality of the prostate (HP:0008775)2.07952560
104Acute myeloid leukemia (HP:0004808)2.07629797
105Anorexia (HP:0002039)2.06580222
106Spondylolisthesis (HP:0003302)2.05629624
107Alveolar cell carcinoma (HP:0006519)2.05299391
108Loss of speech (HP:0002371)2.03929696
109Gangrene (HP:0100758)2.02754625
110Chronic sinusitis (HP:0011109)2.02677291
111Arthralgia (HP:0002829)2.02641372
112Emphysema (HP:0002097)2.01588083
113Abnormality of the pleura (HP:0002103)2.00970952
114Papilledema (HP:0001085)2.00597143
115Albinism (HP:0001022)1.99795843
116Prolonged bleeding time (HP:0003010)1.98638402
117Hypoplasia of the thymus (HP:0000778)1.98085335
118Esophageal varix (HP:0002040)1.97713050
119Recurrent pneumonia (HP:0006532)1.96780663
120Vertebral compression fractures (HP:0002953)1.95328575
121Polyneuropathy (HP:0001271)1.94203468
122Urticaria (HP:0001025)1.94190052
123Neoplasm of the tracheobronchial system (HP:0100552)1.91946575

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.76982091
2JAK33.77877353
3MAP4K13.72576748
4TYK23.33045734
5IKBKB3.22687347
6TBK13.07560638
7TXK2.84657999
8IKBKE2.72910015
9MAP3K132.62184754
10CHUK2.37957839
11IRAK42.35979565
12PRPF4B2.34869163
13KIT2.16890302
14JAK12.10204605
15IRAK32.02495331
16RIPK42.01600653
17ZAP701.97090083
18STK101.79807430
19BLK1.68368151
20PIM21.68357534
21FGFR41.64341780
22MST41.60681574
23FGFR31.49068412
24BTK1.48646168
25SYK1.45832461
26PIM11.44394610
27EPHB11.42644256
28TEC1.39680778
29TESK21.37642928
30CSF1R1.37572836
31LCK1.36914442
32FLT31.32132381
33NLK1.29797781
34ITK1.28300702
35TNK21.25290333
36TGFBR21.20415899
37LRRK21.20328725
38JAK21.18160678
39RPS6KA41.15704455
40MAPK71.14075496
41CSK1.13888402
42ERN11.13160976
43GRK71.11566399
44HCK1.08996420
45CAMKK21.08631475
46TGFBR11.08098507
47GRK61.07984519
48MAP2K31.07791429
49MAP3K101.07691101
50EPHA31.05818338
51EEF2K0.95752601
52PTK60.89317990
53NME20.86843965
54SIK30.85564044
55STK40.84294043
56IRAK10.82497388
57MAP3K30.82420666
58MAPK150.82263784
59NEK90.79653735
60BMPR20.78972379
61TAOK20.76811156
62SIK20.75310992
63MAPKAPK20.74597917
64TRPM70.73496928
65LYN0.72802772
66PIK3CG0.72673765
67MAPK110.70424333
68CAMKK10.68678291
69TAOK30.68647116
70PDK10.66623464
71MARK30.66195667
72BRD40.65060841
73PRKCQ0.64634433
74CDK90.64537293
75MAPK120.64204691
76RPS6KC10.63976897
77RPS6KL10.63976897
78TRIB30.63840561
79MAPK40.58521050
80TAOK10.57900100
81STK240.56023500
82PRKAA20.55648435
83CDK40.54561445
84CDK60.53800331
85MATK0.53186242
86TTN0.51151417
87CLK10.50577284
88ABL10.50113139
89BMX0.49435461
90MAP3K110.46449552
91RPS6KA50.43734594
92PKN20.43443461
93FES0.42735603
94KDR0.41772670
95ADRBK20.40724672
96PRKCD0.40537779
97RPS6KA20.40341539
98EIF2AK20.39955954
99MAP3K10.39409863
100STK30.37640756
101HIPK20.37604969
102CDC42BPA0.37604713
103PASK0.37364821
104CDK120.36895977
105RPS6KA10.35843259
106MAP2K20.34705335
107MARK20.34019067
108EGFR0.33751341
109PDPK10.33618838
110FYN0.33033368
111MOS0.32741390
112MAP3K50.32320878
113PDGFRB0.32036687
114RPS6KB20.31605459
115RAF10.31509488
116MAP3K80.30956038
117BMPR1B0.30603711
118RPS6KA60.29963513
119DYRK1B0.29957774
120PRKG20.29474733
121RET0.27138881
122MAP2K60.26561998
123MELK0.26492364
124MAP3K70.25379145
125PKN10.25344564
126MAPK30.24545838
127INSR0.24134697
128IGF1R0.23786185
129FGR0.22187394
130IRAK20.22078227

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.29526904
2NF-kappa B signaling pathway_Homo sapiens_hsa040643.04609353
3Graft-versus-host disease_Homo sapiens_hsa053322.89513797
4Leishmaniasis_Homo sapiens_hsa051402.88628367
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.73731275
6Primary immunodeficiency_Homo sapiens_hsa053402.62083153
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.58827006
8Measles_Homo sapiens_hsa051622.47195221
9Osteoclast differentiation_Homo sapiens_hsa043802.34354266
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.23177016
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.20123889
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.17931341
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.05967341
14TNF signaling pathway_Homo sapiens_hsa046681.99877831
15Autoimmune thyroid disease_Homo sapiens_hsa053201.97310756
16Toxoplasmosis_Homo sapiens_hsa051451.95133636
17Antigen processing and presentation_Homo sapiens_hsa046121.92844043
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.90362060
19B cell receptor signaling pathway_Homo sapiens_hsa046621.90212839
20Legionellosis_Homo sapiens_hsa051341.83746368
21T cell receptor signaling pathway_Homo sapiens_hsa046601.78535696
22Herpes simplex infection_Homo sapiens_hsa051681.75416837
23Type I diabetes mellitus_Homo sapiens_hsa049401.73985283
24Influenza A_Homo sapiens_hsa051641.70272556
25Hematopoietic cell lineage_Homo sapiens_hsa046401.67767395
26Apoptosis_Homo sapiens_hsa042101.63749799
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.62894094
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.53344624
29Viral myocarditis_Homo sapiens_hsa054161.52206507
30Pertussis_Homo sapiens_hsa051331.51092008
31Tuberculosis_Homo sapiens_hsa051521.50958155
32Asthma_Homo sapiens_hsa053101.49832752
33Shigellosis_Homo sapiens_hsa051311.49593993
34Chemokine signaling pathway_Homo sapiens_hsa040621.48537488
35Malaria_Homo sapiens_hsa051441.48032917
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38354487
37Acute myeloid leukemia_Homo sapiens_hsa052211.35315495
38Hepatitis B_Homo sapiens_hsa051611.30010439
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25000730
40Staphylococcus aureus infection_Homo sapiens_hsa051501.21366789
41Salmonella infection_Homo sapiens_hsa051321.18111982
42Rheumatoid arthritis_Homo sapiens_hsa053231.14185568
43Chronic myeloid leukemia_Homo sapiens_hsa052201.12281171
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12155242
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10862588
46Small cell lung cancer_Homo sapiens_hsa052221.09315321
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05403682
48Hepatitis C_Homo sapiens_hsa051601.05054518
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.04441767
50Prolactin signaling pathway_Homo sapiens_hsa049171.00967597
51Epstein-Barr virus infection_Homo sapiens_hsa051690.99876391
52Pancreatic cancer_Homo sapiens_hsa052120.89551458
53African trypanosomiasis_Homo sapiens_hsa051430.89165824
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88654991
55p53 signaling pathway_Homo sapiens_hsa041150.87273898
56Viral carcinogenesis_Homo sapiens_hsa052030.85599120
57Platelet activation_Homo sapiens_hsa046110.85472044
58HTLV-I infection_Homo sapiens_hsa051660.84766326
59Ribosome_Homo sapiens_hsa030100.78949432
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76323167
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.71472511
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.63321745
63Other glycan degradation_Homo sapiens_hsa005110.63209199
64Amoebiasis_Homo sapiens_hsa051460.53256055
65VEGF signaling pathway_Homo sapiens_hsa043700.53090615
66MicroRNAs in cancer_Homo sapiens_hsa052060.48829682
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48624663
68Notch signaling pathway_Homo sapiens_hsa043300.47067311
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46148757
70Lysosome_Homo sapiens_hsa041420.45808330
71HIF-1 signaling pathway_Homo sapiens_hsa040660.45176151
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44681743
73* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43850009
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42665219
75Phagosome_Homo sapiens_hsa041450.41301420
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.41017294
77Non-small cell lung cancer_Homo sapiens_hsa052230.39919145
78MAPK signaling pathway_Homo sapiens_hsa040100.39864473
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39776386
80Proteoglycans in cancer_Homo sapiens_hsa052050.39741653
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39436875
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39263665
83Renal cell carcinoma_Homo sapiens_hsa052110.39076380
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38370285
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36704526
86Insulin resistance_Homo sapiens_hsa049310.34421648
87FoxO signaling pathway_Homo sapiens_hsa040680.34376730
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34126946
89Systemic lupus erythematosus_Homo sapiens_hsa053220.32478409
90Colorectal cancer_Homo sapiens_hsa052100.32375456
91mTOR signaling pathway_Homo sapiens_hsa041500.32174096
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32051555
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31676169
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.31079302
95* Pathways in cancer_Homo sapiens_hsa052000.31005303
96Arachidonic acid metabolism_Homo sapiens_hsa005900.29420296
97Choline metabolism in cancer_Homo sapiens_hsa052310.28111550
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.27769791
99Renin-angiotensin system_Homo sapiens_hsa046140.27569381
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26982753
101Base excision repair_Homo sapiens_hsa034100.26854857
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.26296445
103GnRH signaling pathway_Homo sapiens_hsa049120.26048466
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25563986
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24542643
106Regulation of autophagy_Homo sapiens_hsa041400.23723714
107Prostate cancer_Homo sapiens_hsa052150.23243077
108Dorso-ventral axis formation_Homo sapiens_hsa043200.22930477
109Endocytosis_Homo sapiens_hsa041440.22720062
110Type II diabetes mellitus_Homo sapiens_hsa049300.21217789
111Prion diseases_Homo sapiens_hsa050200.21073940
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20612073
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20245294
114Inositol phosphate metabolism_Homo sapiens_hsa005620.17313227
115Caffeine metabolism_Homo sapiens_hsa002320.16815368
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16138255
117DNA replication_Homo sapiens_hsa030300.15724863

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »