PTGDR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)9.11506609
2negative regulation of cell killing (GO:0031342)9.11506609
3cellular response to interleukin-15 (GO:0071350)7.07249607
4response to interleukin-15 (GO:0070672)6.56510416
5regulation of B cell receptor signaling pathway (GO:0050855)6.28227801
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.09648026
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.08588961
8antigen processing and presentation of endogenous antigen (GO:0019883)5.61232725
9tolerance induction (GO:0002507)5.60250006
10neuronal action potential (GO:0019228)5.59498232
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.52286303
12negative regulation of dendrite morphogenesis (GO:0050774)5.13234978
13negative T cell selection (GO:0043383)5.01712480
14negative thymic T cell selection (GO:0045060)5.00885879
15urinary tract smooth muscle contraction (GO:0014848)5.00155975
16negative regulation of lymphocyte mediated immunity (GO:0002707)4.87847110
17regulation of natural killer cell mediated immunity (GO:0002715)4.79328125
18regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.79328125
19positive regulation of gamma-delta T cell activation (GO:0046645)4.79236267
20behavioral response to pain (GO:0048266)4.69208612
21regulation of T cell mediated cytotoxicity (GO:0001914)4.62457413
22regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.54017965
23regulation of platelet aggregation (GO:0090330)4.52831546
24regulation of leukocyte mediated cytotoxicity (GO:0001910)4.48971040
25positive regulation of T cell mediated cytotoxicity (GO:0001916)4.43756865
26negative regulation of T cell mediated immunity (GO:0002710)4.43488992
27regulation of gamma-delta T cell differentiation (GO:0045586)4.40072866
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.33890776
29negative regulation of homotypic cell-cell adhesion (GO:0034111)4.32349441
30neuron cell-cell adhesion (GO:0007158)4.23457268
31positive thymic T cell selection (GO:0045059)4.23321420
32interferon-gamma production (GO:0032609)4.19317397
33regulation of gamma-delta T cell activation (GO:0046643)4.19202366
34response to muramyl dipeptide (GO:0032495)4.17435487
35positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.17033895
36negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.16044719
37regulation of memory T cell differentiation (GO:0043380)4.13787879
38negative regulation of leukocyte mediated immunity (GO:0002704)4.11206368
39regulation of cell killing (GO:0031341)4.10265847
40cornea development in camera-type eye (GO:0061303)4.08105373
41positive regulation of natural killer cell mediated immunity (GO:0002717)4.03950514
42peripheral nervous system neuron development (GO:0048935)4.03458762
43leukocyte aggregation (GO:0070486)4.02511048
44presynaptic membrane assembly (GO:0097105)4.02171678
45negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.01054719
46membrane depolarization during action potential (GO:0086010)4.00338437
47negative regulation of innate immune response (GO:0045824)3.98011533
48neutrophil activation involved in immune response (GO:0002283)3.82632582
49positive regulation of synaptic transmission, GABAergic (GO:0032230)3.82031642
50mast cell activation (GO:0045576)3.81311355
51neutrophil activation (GO:0042119)3.80558169
52positive regulation of cell killing (GO:0031343)3.80522560
53leukocyte degranulation (GO:0043299)3.76861713
54regulation of alpha-beta T cell proliferation (GO:0046640)3.75841964
55negative regulation of dendrite development (GO:2000171)3.75392402
56activated T cell proliferation (GO:0050798)3.75343518
57antigen processing and presentation via MHC class Ib (GO:0002475)3.74168806
58positive T cell selection (GO:0043368)3.74035955
59natural killer cell activation (GO:0030101)3.67994798
60response to pain (GO:0048265)3.65695684
61thymic T cell selection (GO:0045061)3.65548735
62natural killer cell activation involved in immune response (GO:0002323)3.62429467
63positive regulation of alpha-beta T cell proliferation (GO:0046641)3.61840887
64positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.61482689
65* adenosine metabolic process (GO:0046085)3.59721979
66T cell migration (GO:0072678)3.54845782
67protein localization to synapse (GO:0035418)3.54773661
68regulation of mast cell degranulation (GO:0043304)3.54652250
69positive regulation of T cell mediated immunity (GO:0002711)3.53771382
70regulation of germinal center formation (GO:0002634)3.53622718
71bundle of His cell to Purkinje myocyte communication (GO:0086069)3.53011672
72negative regulation of synaptic transmission, GABAergic (GO:0032229)3.50588177
73negative regulation of T-helper cell differentiation (GO:0045623)3.50578367
74negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.50578367
75cellular extravasation (GO:0045123)3.49723134
76T cell selection (GO:0045058)3.47907579
77lymph node development (GO:0048535)3.47573447
78positive regulation of T cell cytokine production (GO:0002726)3.46529708
79mast cell activation involved in immune response (GO:0002279)3.46104473
80mast cell degranulation (GO:0043303)3.46104473
81regulation of T cell mediated immunity (GO:0002709)3.45116099
82regulation of regulatory T cell differentiation (GO:0045589)3.41620596
83negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.41489602
84presynaptic membrane organization (GO:0097090)3.40038946
85regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.38653989
86vocalization behavior (GO:0071625)3.36928171
87regulation of homotypic cell-cell adhesion (GO:0034110)3.30699436
88regulation of mast cell activation (GO:0033003)3.29420694
89granulocyte activation (GO:0036230)3.29029961
90regulation of mast cell activation involved in immune response (GO:0033006)3.27731713
91detection of calcium ion (GO:0005513)3.26232873
92action potential (GO:0001508)3.21841709
93cerebral cortex radially oriented cell migration (GO:0021799)3.20213409
94desmosome organization (GO:0002934)3.18797415
95regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.15374784
96postsynaptic membrane organization (GO:0001941)3.15141665
97cell migration in hindbrain (GO:0021535)3.13821279
98positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.11877069
99neuromuscular synaptic transmission (GO:0007274)3.08541042
100ionotropic glutamate receptor signaling pathway (GO:0035235)3.06502862
101negative regulation of adaptive immune response (GO:0002820)3.06374510
102glycosphingolipid biosynthetic process (GO:0006688)3.05214319
103megakaryocyte development (GO:0035855)3.03502761
104regulation of leukocyte mediated immunity (GO:0002703)3.02276904
105positive regulation of lymphocyte mediated immunity (GO:0002708)3.01934724
106regulation of lymphocyte mediated immunity (GO:0002706)3.01394761
107myeloid cell activation involved in immune response (GO:0002275)2.98414946
108regulation of sensory perception of pain (GO:0051930)2.97587252
109regulation of sensory perception (GO:0051931)2.97587252
110B cell receptor signaling pathway (GO:0050853)2.97230320
111dendritic cell chemotaxis (GO:0002407)2.97066249
112cellular defense response (GO:0006968)2.96991085
113regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.96351132
114regulation of myeloid leukocyte mediated immunity (GO:0002886)2.95522436
115positive regulation of cardiac muscle cell differentiation (GO:2000727)2.94297075
116positive regulation of cardiac muscle hypertrophy (GO:0010613)2.93204310
117positive regulation of muscle hypertrophy (GO:0014742)2.93204310
118natural killer cell differentiation (GO:0001779)2.93190426
119phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.92153719
120positive regulation of mast cell activation (GO:0033005)2.91849609
121regulation of B cell differentiation (GO:0045577)2.91488279
122RNA destabilization (GO:0050779)2.90980930
123T cell proliferation (GO:0042098)2.90508803
124neuronal action potential propagation (GO:0019227)2.90474670
125negative regulation of calcium ion transport into cytosol (GO:0010523)2.89002566
126positive regulation of macrophage differentiation (GO:0045651)2.88865125
127adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.88621665
128negative regulation of interleukin-1 beta production (GO:0032691)2.88121682
129regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.88094126
130negative regulation of alpha-beta T cell activation (GO:0046636)2.87935543
131detection of mechanical stimulus involved in sensory perception (GO:0050974)2.86404952
132regulation of T cell tolerance induction (GO:0002664)2.84794012
133positive regulation of leukocyte mediated immunity (GO:0002705)2.84547039
134positive regulation of amino acid transport (GO:0051957)2.83942773
135positive regulation of action potential (GO:0045760)2.83405590
136T cell receptor signaling pathway (GO:0050852)2.83384510
137positive regulation of tolerance induction (GO:0002645)2.82997743
138regulation of T-helper 1 type immune response (GO:0002825)2.82045964
139dendritic cell migration (GO:0036336)2.80986750
140positive regulation of interleukin-17 production (GO:0032740)2.80525866
141antigen receptor-mediated signaling pathway (GO:0050851)2.80321006
142positive regulation by symbiont of host defense response (GO:0052509)2.78286452
143modulation by symbiont of host defense response (GO:0052031)2.78286452
144modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.78286452
145modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.78286452
146positive regulation by organism of defense response of other organism involved in symbiotic interact2.78286452
147modulation by symbiont of host immune response (GO:0052553)2.78286452
148regulation of collateral sprouting (GO:0048670)2.77909176
149hepatocyte apoptotic process (GO:0097284)2.77619375
150membrane depolarization (GO:0051899)2.77541537
151glutamate receptor signaling pathway (GO:0007215)2.74868889
152acrosome reaction (GO:0007340)2.73660530
153regulation of synaptic transmission, GABAergic (GO:0032228)2.72965641
154regulation of synaptic transmission, glutamatergic (GO:0051966)2.72011706
155synaptic vesicle exocytosis (GO:0016079)2.69282539
156positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.69072234
157detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.65658630
158detection of temperature stimulus involved in sensory perception (GO:0050961)2.65658630
159sensory perception of pain (GO:0019233)2.63469267
160membrane assembly (GO:0071709)2.63159838
161response to ATP (GO:0033198)2.61808015
162neurofilament cytoskeleton organization (GO:0060052)2.61127863
163regulation of rhodopsin mediated signaling pathway (GO:0022400)2.60335249
164keratinocyte development (GO:0003334)2.59184195
165sympathetic nervous system development (GO:0048485)2.57475632
166positive regulation of cellular amide metabolic process (GO:0034250)2.57358307
167positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.56107719
168regulation of synaptic vesicle exocytosis (GO:2000300)2.54564889
169aggressive behavior (GO:0002118)2.53112377
170regulation of action potential (GO:0098900)2.53092342
171keratinocyte proliferation (GO:0043616)2.52599098
172potassium ion export (GO:0071435)2.51681924
173negative regulation of keratinocyte proliferation (GO:0010839)2.48971518
174purinergic nucleotide receptor signaling pathway (GO:0035590)2.48546777
175opioid receptor signaling pathway (GO:0038003)2.47843956
176potassium ion transmembrane transport (GO:0071805)2.47338833
177cellular potassium ion transport (GO:0071804)2.47338833
178rhodopsin mediated signaling pathway (GO:0016056)2.46708814
179regulation of glutamate receptor signaling pathway (GO:1900449)2.45968773
180detection of temperature stimulus (GO:0016048)2.44620753
181regulation of synapse assembly (GO:0051963)2.44553131
182modulation by virus of host process (GO:0019054)2.43973593
183retinal ganglion cell axon guidance (GO:0031290)2.42477282
184transmission of nerve impulse (GO:0019226)2.41751473
185neuron-neuron synaptic transmission (GO:0007270)2.40114631
186synaptic transmission, glutamatergic (GO:0035249)2.40049670
187multicellular organismal response to stress (GO:0033555)2.39343688
188dopamine receptor signaling pathway (GO:0007212)2.39124075
189calcium-mediated signaling using intracellular calcium source (GO:0035584)2.38415797
190potassium ion transport (GO:0006813)2.38030646
191positive regulation of synapse assembly (GO:0051965)2.37973373
192limb bud formation (GO:0060174)2.35192888
193regulation of neurotransmitter secretion (GO:0046928)2.34905811
194serotonin receptor signaling pathway (GO:0007210)2.33883100
195neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.32586240
196positive regulation of potassium ion transmembrane transport (GO:1901381)2.32166525
197negative regulation of platelet activation (GO:0010544)2.32049492
198regulation of cardiac muscle hypertrophy (GO:0010611)2.32015822
199negative regulation of protein localization to cell surface (GO:2000009)2.31996017
200regulation of membrane depolarization (GO:0003254)2.29867755

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.86473221
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.70806929
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.22764494
4RUNX_20019798_ChIP-Seq_JUKART_Human4.37428264
5GBX2_23144817_ChIP-Seq_PC3_Human4.05113511
6EZH2_22144423_ChIP-Seq_EOC_Human3.59187203
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.31942410
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.28264747
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.16387692
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.06867537
11* MYB_26560356_Chip-Seq_TH2_Human2.98088571
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.82994425
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.80228430
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.79742744
15* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.75451945
16SCL_19346495_ChIP-Seq_HPC-7_Human2.71854093
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68397998
18TAF15_26573619_Chip-Seq_HEK293_Human2.67588894
19VDR_22108803_ChIP-Seq_LS180_Human2.58350802
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.56147154
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53781841
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52028366
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.47740400
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.47209864
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.47135691
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46740593
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45820467
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45577757
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.44495933
30JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38603254
31IRF8_27001747_Chip-Seq_BMDM_Mouse2.35288138
32* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33509644
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.29922693
34GATA3_27048872_Chip-Seq_THYMUS_Human2.29521696
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29403782
36RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27802821
37EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27802821
38BMI1_23680149_ChIP-Seq_NPCS_Mouse2.26000198
39ELF1_17652178_ChIP-ChIP_JURKAT_Human2.24777424
40MAF_26560356_Chip-Seq_TH1_Human2.21779052
41MYB_26560356_Chip-Seq_TH1_Human2.17140030
42RUNX1_22412390_ChIP-Seq_EML_Mouse2.12698072
43* UTX_26944678_Chip-Seq_JUKART_Human2.09225430
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08186227
45SPI1_23547873_ChIP-Seq_NB4_Human2.06646038
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05696792
47SMAD_19615063_ChIP-ChIP_OVARY_Human2.03415500
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02773208
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.99957722
50GATA3_26560356_Chip-Seq_TH2_Human1.99341781
51AR_21572438_ChIP-Seq_LNCaP_Human1.98913456
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.96967289
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.96761051
54P300_19829295_ChIP-Seq_ESCs_Human1.94558080
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.92603994
56MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91532222
57* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86253376
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.85550426
59* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85128219
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.83932981
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.82858745
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82483046
63SPI1_23127762_ChIP-Seq_K562_Human1.80303762
64SMAD4_21799915_ChIP-Seq_A2780_Human1.79716411
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.77273501
66* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76749120
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75267358
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72014295
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.71035951
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.69088052
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68530010
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66568225
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66310993
74GATA1_22025678_ChIP-Seq_K562_Human1.64095800
75BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64063661
76MAF_26560356_Chip-Seq_TH2_Human1.62700478
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60619118
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.60344357
79REST_21632747_ChIP-Seq_MESCs_Mouse1.59337206
80RNF2_27304074_Chip-Seq_NSC_Mouse1.58497690
81IGF1R_20145208_ChIP-Seq_DFB_Human1.53080121
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52864046
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49798197
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49360811
85GATA2_22383799_ChIP-Seq_G1ME_Mouse1.48426819
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47160753
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47160753
88VDR_24787735_ChIP-Seq_THP-1_Human1.46215098
89* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45736750
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45510667
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.42667537
92IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42059778
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42006532
94VDR_24763502_ChIP-Seq_THP-1_Human1.41844148
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.41311673
96GATA1_19941827_ChIP-Seq_MEL_Mouse1.39275211
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.38765791
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37291191
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37290422
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36891945
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35696147
102CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35299789
103E2F1_18555785_Chip-Seq_ESCs_Mouse1.35188181
104TP53_18474530_ChIP-ChIP_U2OS_Human1.34992721
105P53_22387025_ChIP-Seq_ESCs_Mouse1.33659585
106WT1_19549856_ChIP-ChIP_CCG9911_Human1.33281868
107PIAS1_25552417_ChIP-Seq_VCAP_Human1.32656090
108CMYC_18555785_Chip-Seq_ESCs_Mouse1.31201405
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30790411
110SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30543701
111* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.30321242
112PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29434335
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28517690
114GATA2_21666600_ChIP-Seq_HMVEC_Human1.28364245
115TCF7_22412390_ChIP-Seq_EML_Mouse1.27987267
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27865037
117RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27146504
118STAT3_23295773_ChIP-Seq_U87_Human1.25964438
119EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.25706739
120AR_25329375_ChIP-Seq_VCAP_Human1.24787495
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24532027
122VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.23571206
123PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22765912
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22250121
125PU_27001747_Chip-Seq_BMDM_Mouse1.22225672
126* AHR_22903824_ChIP-Seq_MCF-7_Human1.20344204
127CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20201996
128TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19920144
129NFE2_27457419_Chip-Seq_LIVER_Mouse1.19623269
130TAL1_26923725_Chip-Seq_HPCs_Mouse1.18550202
131PRDM14_20953172_ChIP-Seq_ESCs_Human1.18471383
132KDM2B_26808549_Chip-Seq_REH_Human1.17481396
133TCF4_23295773_ChIP-Seq_U87_Human1.17096711
134* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17068325
135NMYC_18555785_Chip-Seq_ESCs_Mouse1.16704402
136ER_23166858_ChIP-Seq_MCF-7_Human1.16638848
137CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16295596
138BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16232802
139* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15735949
140JUN_21703547_ChIP-Seq_K562_Human1.15625067
141P300_18555785_Chip-Seq_ESCs_Mouse1.15393203
142MYC_22102868_ChIP-Seq_BL_Human1.14120029
143STAT3_18555785_Chip-Seq_ESCs_Mouse1.13578975
144FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12768753
145TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11866639
146RUNX2_22187159_ChIP-Seq_PCA_Human1.10954339
147SOX2_18555785_Chip-Seq_ESCs_Mouse1.10762946
148BP1_19119308_ChIP-ChIP_Hs578T_Human1.10053960
149REST_18959480_ChIP-ChIP_MESCs_Mouse1.09887834
150RUNX1_27457419_Chip-Seq_LIVER_Mouse1.08590608
151NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08475607
152FUS_26573619_Chip-Seq_HEK293_Human1.08369660
153IRF1_19129219_ChIP-ChIP_H3396_Human1.07539573
154CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07374623
155DROSHA_22980978_ChIP-Seq_HELA_Human1.07341907
156SMAD3_21741376_ChIP-Seq_HESCs_Human1.06839384
157* ARNT_22903824_ChIP-Seq_MCF-7_Human1.06810654
158ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06577972
159STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06335624
160GATA1_19941826_ChIP-Seq_K562_Human1.06160534
161EZH2_27294783_Chip-Seq_NPCs_Mouse1.06054388
162CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04369290
163OCT4_18555785_Chip-Seq_ESCs_Mouse1.03334736
164ESR1_20079471_ChIP-ChIP_T-47D_Human1.02570725
165BCL6_27268052_Chip-Seq_Bcells_Human1.00177262
166ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00014278
167GATA2_19941826_ChIP-Seq_K562_Human0.99560693
168SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99005313
169KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95753008
170SMRT_27268052_Chip-Seq_Bcells_Human0.95283549
171SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95273812
172GATA3_26560356_Chip-Seq_TH1_Human0.95164680
173PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95037715
174CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94563430
175GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93537061
176KDM2B_26808549_Chip-Seq_DND41_Human0.93468092
177KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92504185
178STAT1_20625510_ChIP-Seq_HELA_Human0.90725602
179TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90397419
180VDR_21846776_ChIP-Seq_THP-1_Human0.86792557
181P300_27268052_Chip-Seq_Bcells_Human0.86629449
182CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85786857
183BCOR_27268052_Chip-Seq_Bcells_Human0.85631342
184RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.83415456
185KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81360581
186* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80881020
187SPI1_20517297_ChIP-Seq_HL60_Human0.77844751
188* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76562344
189TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.76516324
190PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75927528
191RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73622499
192NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.73068487
193SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.71095089
194ETS1_22383799_ChIP-Seq_G1ME_Mouse0.70692734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception6.16924218
2MP0002736_abnormal_nociception_after5.91369393
3MP0002735_abnormal_chemical_nociception5.90170003
4MP0001986_abnormal_taste_sensitivity4.31633835
5MP0003436_decreased_susceptibility_to4.06200391
6MP0001835_abnormal_antigen_presentation3.68599171
7MP0003763_abnormal_thymus_physiology3.56812482
8MP0002734_abnormal_mechanical_nocicepti3.24791253
9MP0005000_abnormal_immune_tolerance3.21408401
10MP0006276_abnormal_autonomic_nervous3.09786460
11MP0000685_abnormal_immune_system3.09317118
12MP0002733_abnormal_thermal_nociception3.07767576
13MP0000465_gastrointestinal_hemorrhage3.05218749
14MP0001800_abnormal_humoral_immune3.04674101
15MP0004270_analgesia2.97387799
16MP0003880_abnormal_central_pattern2.81074639
17MP0001970_abnormal_pain_threshold2.77617010
18MP0002723_abnormal_immune_serum2.75783111
19MP0001188_hyperpigmentation2.75021115
20MP0009785_altered_susceptibility_to2.70685596
21MP0001819_abnormal_immune_cell2.59845222
22MP0002420_abnormal_adaptive_immunity2.58573290
23MP0005025_abnormal_response_to2.51590349
24MP0002452_abnormal_antigen_presenting2.50619875
25MP0002419_abnormal_innate_immunity2.50613263
26MP0001790_abnormal_immune_system2.43476950
27MP0005387_immune_system_phenotype2.43476950
28MP0006082_CNS_inflammation2.41745636
29MP0001533_abnormal_skeleton_physiology2.40129221
30MP0005464_abnormal_platelet_physiology2.30454272
31MP0002398_abnormal_bone_marrow2.16514258
32MP0005646_abnormal_pituitary_gland2.15738969
33MP0002272_abnormal_nervous_system2.07834398
34MP0008260_abnormal_autophagy2.07721060
35MP0004859_abnormal_synaptic_plasticity2.05692284
36MP0002148_abnormal_hypersensitivity_rea2.05248911
37MP0001984_abnormal_olfaction2.05124567
38MP0000716_abnormal_immune_system2.05033587
39MP0004858_abnormal_nervous_system2.01673511
40* MP0002405_respiratory_system_inflammati2.01657950
41MP0000703_abnormal_thymus_morphology1.99136266
42MP0004947_skin_inflammation1.97690702
43MP0002722_abnormal_immune_system1.97194910
44MP0002067_abnormal_sensory_capabilities1.96543480
45MP0003635_abnormal_synaptic_transmissio1.93771411
46MP0002184_abnormal_innervation1.92726563
47MP0000689_abnormal_spleen_morphology1.89724160
48MP0001851_eye_inflammation1.87016088
49MP0010155_abnormal_intestine_physiology1.86307378
50MP0005075_abnormal_melanosome_morpholog1.79846324
51MP0003787_abnormal_imprinting1.77950756
52MP0003866_abnormal_defecation1.77378899
53MP0003183_abnormal_peptide_metabolism1.75776882
54MP0000566_synostosis1.75077048
55MP0001486_abnormal_startle_reflex1.71122318
56MP0003828_pulmonary_edema1.70267640
57MP0009745_abnormal_behavioral_response1.68987971
58MP0003303_peritoneal_inflammation1.66347816
59MP0001845_abnormal_inflammatory_respons1.64656678
60MP0002933_joint_inflammation1.63597365
61MP0002277_abnormal_respiratory_mucosa1.62591497
62MP0002429_abnormal_blood_cell1.60112625
63MP0002572_abnormal_emotion/affect_behav1.59627465
64MP0005171_absent_coat_pigmentation1.57759571
65MP0002166_altered_tumor_susceptibility1.55889770
66MP0002638_abnormal_pupillary_reflex1.51727444
67MP0002064_seizures1.51388938
68MP0002063_abnormal_learning/memory/cond1.49027288
69MP0000516_abnormal_urinary_system1.48910195
70MP0005367_renal/urinary_system_phenotyp1.48910195
71MP0005423_abnormal_somatic_nervous1.44592247
72MP0009333_abnormal_splenocyte_physiolog1.43914236
73MP0009046_muscle_twitch1.37153039
74MP0003656_abnormal_erythrocyte_physiolo1.36840893
75MP0008789_abnormal_olfactory_epithelium1.36609052
76MP0002998_abnormal_bone_remodeling1.36019940
77MP0001501_abnormal_sleep_pattern1.35802892
78MP0003941_abnormal_skin_development1.33751496
79MP0006292_abnormal_olfactory_placode1.30648714
80MP0002102_abnormal_ear_morphology1.29967991
81MP0005310_abnormal_salivary_gland1.28210296
82MP0000778_abnormal_nervous_system1.27661176
83MP0009764_decreased_sensitivity_to1.27156009
84MP0002009_preneoplasia1.26581185
85MP0001440_abnormal_grooming_behavior1.25975914
86MP0005645_abnormal_hypothalamus_physiol1.25536092
87MP0004043_abnormal_pH_regulation1.24219703
88MP0002138_abnormal_hepatobiliary_system1.23932797
89MP0002751_abnormal_autonomic_nervous1.23168151
90MP0005394_taste/olfaction_phenotype1.20540148
91MP0005499_abnormal_olfactory_system1.20540148
92MP0002557_abnormal_social/conspecific_i1.19876512
93MP0009278_abnormal_bone_marrow1.17172040
94MP0003300_gastrointestinal_ulcer1.17132554
95MP0002876_abnormal_thyroid_physiology1.15296504
96MP0004142_abnormal_muscle_tone1.15153549
97MP0004381_abnormal_hair_follicle1.13703599
98MP0008469_abnormal_protein_level1.12569339
99MP0001905_abnormal_dopamine_level1.12473701
100MP0002006_tumorigenesis1.10682083
101MP0001346_abnormal_lacrimal_gland1.08239647
102MP0000858_altered_metastatic_potential1.06651134
103MP0005390_skeleton_phenotype1.06026329
104MP0004742_abnormal_vestibular_system1.05307091
105MP0010386_abnormal_urinary_bladder1.02674645
106MP0003136_yellow_coat_color1.02431750
107MP0004130_abnormal_muscle_cell1.02253132
108MP0000015_abnormal_ear_pigmentation1.01301522
109MP0010771_integument_phenotype1.00889507
110MP0001873_stomach_inflammation1.00038131
111MP0005379_endocrine/exocrine_gland_phen0.99771373
112MP0001270_distended_abdomen0.98158931
113MP0003195_calcinosis0.96886143
114MP0009250_abnormal_appendicular_skeleto0.96022138
115MP0003878_abnormal_ear_physiology0.95001729
116MP0005377_hearing/vestibular/ear_phenot0.95001729
117MP0000579_abnormal_nail_morphology0.93895443
118MP0003191_abnormal_cellular_cholesterol0.93619945
119MP0009763_increased_sensitivity_to0.93343460
120MP0000681_abnormal_thyroid_gland0.92668967
121MP0002882_abnormal_neuron_morphology0.92641264
122MP0005409_darkened_coat_color0.92546523
123MP0001529_abnormal_vocalization0.90198757
124MP0001853_heart_inflammation0.90007503
125MP0000538_abnormal_urinary_bladder0.89800618
126MP0002837_dystrophic_cardiac_calcinosis0.88799937
127MP0003315_abnormal_perineum_morphology0.88462167
128MP0000372_irregular_coat_pigmentation0.88165899
129MP0003638_abnormal_response/metabolism_0.87111493
130MP0000569_abnormal_digit_pigmentation0.87048306
131MP0005083_abnormal_biliary_tract0.86327797
132MP0002254_reproductive_system_inflammat0.85614349
133MP0000955_abnormal_spinal_cord0.85550594
134MP0004147_increased_porphyrin_level0.85257512
135MP0000249_abnormal_blood_vessel0.85223344
136MP0003252_abnormal_bile_duct0.84837045
137MP0000026_abnormal_inner_ear0.84668567
138MP0002752_abnormal_somatic_nervous0.84372786
139MP0003879_abnormal_hair_cell0.82814308
140MP0004811_abnormal_neuron_physiology0.81816319
141MP0002163_abnormal_gland_morphology0.80837402
142MP0000427_abnormal_hair_cycle0.80202208
143MP0001963_abnormal_hearing_physiology0.78558749
144MP0001765_abnormal_ion_homeostasis0.77500364
145MP0003724_increased_susceptibility_to0.73296139
146MP0003172_abnormal_lysosome_physiology0.72208933
147MP0002066_abnormal_motor_capabilities/c0.69389021
148MP0005397_hematopoietic_system_phenotyp0.69292571
149MP0001545_abnormal_hematopoietic_system0.69292571
150MP0009765_abnormal_xenobiotic_induced0.69031665
151MP0003795_abnormal_bone_structure0.66803027
152MP0001664_abnormal_digestion0.65736039
153MP0003938_abnormal_ear_development0.65516295
154MP0008872_abnormal_physiological_respon0.64913570
155MP0002653_abnormal_ependyma_morphology0.64839823
156MP0001663_abnormal_digestive_system0.64555834
157MP0002396_abnormal_hematopoietic_system0.64500166
158MP0008877_abnormal_DNA_methylation0.64402990
159MP0001502_abnormal_circadian_rhythm0.62733949
160MP0004885_abnormal_endolymph0.62149906
161MP0008569_lethality_at_weaning0.61877036
162MP0002095_abnormal_skin_pigmentation0.60152943
163MP0005167_abnormal_blood-brain_barrier0.60050794
164MP0002928_abnormal_bile_duct0.58886904
165MP0004484_altered_response_of0.58217685
166MP0001485_abnormal_pinna_reflex0.57904599
167MP0002233_abnormal_nose_morphology0.57622972
168MP0004883_abnormal_blood_vessel0.56581277
169MP0002019_abnormal_tumor_incidence0.56124073
170MP0003448_altered_tumor_morphology0.55778762
171MP0003690_abnormal_glial_cell0.55365160
172MP0008874_decreased_physiological_sensi0.55043964
173MP0000631_abnormal_neuroendocrine_gland0.54702515
174MP0005084_abnormal_gallbladder_morpholo0.54207612
175MP0002132_abnormal_respiratory_system0.53603329
176MP0000383_abnormal_hair_follicle0.52532142
177MP0005671_abnormal_response_to0.51874505
178MP0000537_abnormal_urethra_morphology0.51537103
179MP0009379_abnormal_foot_pigmentation0.50929739
180MP0005551_abnormal_eye_electrophysiolog0.50919469
181MP0003011_delayed_dark_adaptation0.50885182
182MP0006054_spinal_hemorrhage0.50220192
183MP0008873_increased_physiological_sensi0.50140355
184MP0003634_abnormal_glial_cell0.49875907
185MP0000049_abnormal_middle_ear0.49046733
186MP0005174_abnormal_tail_pigmentation0.48946771
187MP0005386_behavior/neurological_phenoty0.48077636
188MP0004924_abnormal_behavior0.48077636

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.65591721
2Abnormality of T cell number (HP:0011839)5.28656466
3Optic neuritis (HP:0100653)5.20440731
4Retrobulbar optic neuritis (HP:0100654)5.20440731
5Myositis (HP:0100614)5.13739136
6Orchitis (HP:0100796)4.93663647
7Eczematoid dermatitis (HP:0000976)4.86281925
8Severe combined immunodeficiency (HP:0004430)4.74522410
9Ulnar claw (HP:0001178)4.70237413
10Gastrointestinal infarctions (HP:0005244)4.69408592
11Elevated erythrocyte sedimentation rate (HP:0003565)4.66515712
12Febrile seizures (HP:0002373)4.56770415
13Abnormal hair whorl (HP:0010721)4.54924927
14Hypothermia (HP:0002045)4.42740171
15Focal motor seizures (HP:0011153)4.29307127
16Stomatitis (HP:0010280)4.26397547
17IgG deficiency (HP:0004315)4.24688167
18Abnormality of T cells (HP:0002843)4.19321738
19Keratoconjunctivitis (HP:0001096)3.93985128
20Recurrent fungal infections (HP:0002841)3.85549717
21Abnormality of eosinophils (HP:0001879)3.81204032
22Keratoconjunctivitis sicca (HP:0001097)3.72646822
23Combined immunodeficiency (HP:0005387)3.64847973
24Encephalitis (HP:0002383)3.64059860
25Recurrent bronchitis (HP:0002837)3.57759957
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.53579452
27Panhypogammaglobulinemia (HP:0003139)3.51026758
28Vasculitis (HP:0002633)3.47732587
29Pustule (HP:0200039)3.46415018
30Atonic seizures (HP:0010819)3.46180548
31Parakeratosis (HP:0001036)3.42107742
32Joint swelling (HP:0001386)3.39227543
33Pulmonary infiltrates (HP:0002113)3.38156166
34Arterial thrombosis (HP:0004420)3.37586001
35Leukocytosis (HP:0001974)3.36944911
36Recurrent bacterial skin infections (HP:0005406)3.36274537
37Aplasia cutis congenita (HP:0001057)3.35459418
38Upper limb muscle weakness (HP:0003484)3.33990478
39Recurrent abscess formation (HP:0002722)3.31107572
40Meningitis (HP:0001287)3.26503060
41Myokymia (HP:0002411)3.24352565
42Chin dimple (HP:0010751)3.21711020
43Mediastinal lymphadenopathy (HP:0100721)3.17905225
44Prolonged bleeding time (HP:0003010)3.16973095
45Hemoptysis (HP:0002105)3.14624507
46Submucous cleft hard palate (HP:0000176)3.13210226
47Chronic mucocutaneous candidiasis (HP:0002728)3.12817142
48Recurrent cutaneous fungal infections (HP:0011370)3.12817142
49Focal seizures (HP:0007359)3.11633265
50Granulocytopenia (HP:0001913)3.07917146
51Epileptic encephalopathy (HP:0200134)3.07907137
52Anorexia (HP:0002039)3.04913144
53Chest pain (HP:0100749)3.03588768
54Abnormality of T cell physiology (HP:0011840)2.98797309
55Thyroiditis (HP:0100646)2.97833401
56Abnormality of macrophages (HP:0004311)2.97633351
57Lip pit (HP:0100267)2.95333915
58Eosinophilia (HP:0001880)2.94470241
59Epistaxis (HP:0000421)2.93839234
60Hyperventilation (HP:0002883)2.88363885
61Dysautonomia (HP:0002459)2.87759322
62Septo-optic dysplasia (HP:0100842)2.83962776
63Stomach cancer (HP:0012126)2.83327709
64Spontaneous hematomas (HP:0007420)2.83164869
65Pulmonary embolism (HP:0002204)2.82149441
66Abnormality of the prostate (HP:0008775)2.81125468
67Dynein arm defect of respiratory motile cilia (HP:0012255)2.80953865
68Absent/shortened dynein arms (HP:0200106)2.80953865
69Alveolar cell carcinoma (HP:0006519)2.79361946
70Retinal dysplasia (HP:0007973)2.78029331
71Increased density of long bones (HP:0006392)2.68898780
72Obstructive lung disease (HP:0006536)2.67511349
73Chronic obstructive pulmonary disease (HP:0006510)2.67511349
74Nasolacrimal duct obstruction (HP:0000579)2.65074950
75White forelock (HP:0002211)2.63642799
76Abnormality of the lacrimal duct (HP:0011481)2.63642250
77Neoplasm of the tracheobronchial system (HP:0100552)2.62596087
78Gingival bleeding (HP:0000225)2.62567005
79Petechiae (HP:0000967)2.61448893
80Bradycardia (HP:0001662)2.60317041
81Gangrene (HP:0100758)2.60174433
82Vertigo (HP:0002321)2.59053521
83Abnormality of the nasolacrimal system (HP:0000614)2.58997389
84Steppage gait (HP:0003376)2.58363738
85Abnormality of B cell number (HP:0010975)2.56894780
86Recurrent skin infections (HP:0001581)2.56719203
87Progressive cerebellar ataxia (HP:0002073)2.52889450
88IgM deficiency (HP:0002850)2.51305696
89Glomerulopathy (HP:0100820)2.51051546
90Hypomagnesemia (HP:0002917)2.51029507
91Patchy hypopigmentation of hair (HP:0011365)2.50293088
92Abnormality of the pleura (HP:0002103)2.49491467
93Medial flaring of the eyebrow (HP:0010747)2.46874349
94Persistence of primary teeth (HP:0006335)2.45162063
95Nephrogenic diabetes insipidus (HP:0009806)2.44459003
96Chronic hepatic failure (HP:0100626)2.44065637
97Lymphopenia (HP:0001888)2.39655471
98Genital tract atresia (HP:0001827)2.37735989
99Abnormality of calcium-phosphate metabolism (HP:0100530)2.34299866
100Diplopia (HP:0000651)2.33703999
101Abnormality of binocular vision (HP:0011514)2.33703999
102Recurrent gram-negative bacterial infections (HP:0005420)2.31994340
103B lymphocytopenia (HP:0010976)2.30759385
104Recurrent viral infections (HP:0004429)2.30754960
105Vaginal atresia (HP:0000148)2.30434858
106Hypoplasia of the thymus (HP:0000778)2.28972890
107Abnormal autonomic nervous system physiology (HP:0012332)2.28881688
108Polyneuropathy (HP:0001271)2.26887702
109Prostate neoplasm (HP:0100787)2.26586679
110Abnormality of cells of the lymphoid lineage (HP:0012140)2.25058472
111Gait imbalance (HP:0002141)2.22765723
112Anhidrosis (HP:0000970)2.22491347
113Hemiplegia (HP:0002301)2.20871614
114Abnormality of secondary sexual hair (HP:0009888)2.19930706
115Abnormality of the axillary hair (HP:0100134)2.19930706
116Abnormality of pain sensation (HP:0010832)2.19558606
117Impaired pain sensation (HP:0007328)2.19558606
118Cutaneous finger syndactyly (HP:0010554)2.19501365
119Abnormality of the parathyroid morphology (HP:0011766)2.18488494
120Absent septum pellucidum (HP:0001331)2.17942756
121Renal cortical cysts (HP:0000803)2.17581694
122Abnormality of the right ventricle (HP:0001707)2.17055391
123Gastrointestinal stroma tumor (HP:0100723)2.16648391
124Failure to thrive in infancy (HP:0001531)2.15227592
125Dysostosis multiplex (HP:0000943)2.15161388
126Chronic otitis media (HP:0000389)2.14750795
127Optic nerve hypoplasia (HP:0000609)2.13980643
128Insidious onset (HP:0003587)2.13677188
129Termporal pattern (HP:0011008)2.13677188
130Inflammation of the large intestine (HP:0002037)2.13259014
131Keratitis (HP:0000491)2.13031702
132Congenital primary aphakia (HP:0007707)2.12448365
133Papilloma (HP:0012740)2.11619510
134Verrucae (HP:0200043)2.11619510
135True hermaphroditism (HP:0010459)2.11201075
136Bronchitis (HP:0012387)2.09818557
137Increased IgM level (HP:0003496)2.08844474
138Hypochromic anemia (HP:0001931)2.08469224
139Segmental peripheral demyelination/remyelination (HP:0003481)2.08340968
140Urticaria (HP:0001025)2.08146050
141Morphological abnormality of the middle ear (HP:0008609)2.07602914
142Abnormality of incisor morphology (HP:0011063)2.05723730
143Premature loss of primary teeth (HP:0006323)2.04437144
144Autoimmune hemolytic anemia (HP:0001890)2.04217548
145Abnormality of the pericardium (HP:0001697)2.03648340
146Osteomalacia (HP:0002749)2.03275610
147Xerostomia (HP:0000217)2.03061595
148Pancreatic fibrosis (HP:0100732)2.01781849
149Amaurosis fugax (HP:0100576)2.01766665
150Clumsiness (HP:0002312)2.01136921
151Increased corneal curvature (HP:0100692)2.01108864
152Keratoconus (HP:0000563)2.01108864
153Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.99915886
154Arthralgia (HP:0002829)1.99795201
155Abnormality of liposaccharide metabolism (HP:0010968)1.96985711
156Abnormality of glycosphingolipid metabolism (HP:0004343)1.96985711
157Abnormality of glycolipid metabolism (HP:0010969)1.96985711
158Fetal akinesia sequence (HP:0001989)1.96822696
159Exotropia (HP:0000577)1.96572730
160Gastrointestinal inflammation (HP:0004386)1.96305757
161Abnormal ciliary motility (HP:0012262)1.95995743
162Abnormality of the septum pellucidum (HP:0007375)1.95302875
163Abnormality of magnesium homeostasis (HP:0004921)1.93855258
164Absence seizures (HP:0002121)1.93762841
165Preaxial hand polydactyly (HP:0001177)1.92669658
166Hypoproteinemia (HP:0003075)1.92025802
167Abnormality of the nasal septum (HP:0000419)1.91946109
168Autoimmune thrombocytopenia (HP:0001973)1.91538249
169Polyphagia (HP:0002591)1.90258389
170Aplasia/Hypoplasia of the tibia (HP:0005772)1.89492330
171Conical tooth (HP:0000698)1.89324250
172Dialeptic seizures (HP:0011146)1.89139444
173Tubulointerstitial nephritis (HP:0001970)1.89054718
174Abnormal respiratory motile cilium morphology (HP:0005938)1.88394167
175Abnormal respiratory epithelium morphology (HP:0012253)1.88394167
176Cupped ear (HP:0000378)1.86062651
177Generalized tonic-clonic seizures (HP:0002069)1.85011490
178Short tibia (HP:0005736)1.84977884
179Nasal speech (HP:0001611)1.84037042
180Abnormality of the corticospinal tract (HP:0002492)1.81746869
181Anosmia (HP:0000458)1.81744483
182Aqueductal stenosis (HP:0002410)1.81346845
183Absent speech (HP:0001344)1.81059210
184Congenital malformation of the right heart (HP:0011723)1.79776268
185Double outlet right ventricle (HP:0001719)1.79776268
186Action tremor (HP:0002345)1.77725229
187Congenital sensorineural hearing impairment (HP:0008527)1.77186634
188Cutaneous syndactyly (HP:0012725)1.76453654
189Aplasia/Hypoplasia of the lens (HP:0008063)1.74855834
190Decreased central vision (HP:0007663)1.74040525
191Curly hair (HP:0002212)1.70664566
192Popliteal pterygium (HP:0009756)1.70236400
193Hip dysplasia (HP:0001385)1.70049418
194Abnormality of midbrain morphology (HP:0002418)1.69758536
195Molar tooth sign on MRI (HP:0002419)1.69758536
196Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.69438100
197Protruding tongue (HP:0010808)1.69371198
198Esotropia (HP:0000565)1.69327262
199Poor coordination (HP:0002370)1.65996278

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.93532295
2SIK34.74319509
3GRK64.36394747
4MAP4K13.52548866
5BMPR1B3.14139090
6MAP3K123.01365704
7RIPK42.81856337
8IKBKE2.70202323
9NTRK32.69849965
10MAP2K22.54334794
11JAK12.49414777
12IKBKB2.10157635
13TBK12.08432034
14GRK52.07120176
15CSK1.99952683
16ZAP701.95013992
17MUSK1.93492178
18TNIK1.91777816
19SIK21.80756170
20MAPK131.78239179
21BTK1.75288602
22MARK31.75215702
23BLK1.73325340
24MAP4K21.66726144
25CDK81.56471971
26SYK1.54781771
27BMPR21.54423815
28YES11.51799006
29MAP2K71.51764361
30KIT1.51452852
31AKT31.51363303
32LCK1.50733559
33TLK11.48973962
34EPHB21.48830668
35TXK1.48369951
36HCK1.46047823
37STK161.45027400
38ARAF1.42694240
39SGK21.41785182
40BCR1.41699735
41PRPF4B1.40505811
42PLK21.39569070
43ITK1.37226321
44TESK21.34097317
45TYK21.34018001
46TNK21.30954286
47LYN1.30745865
48IRAK11.26800625
49MAP3K141.26468855
50EPHA41.25905610
51ADRBK21.19947830
52SGK4941.18125556
53SGK2231.18125556
54MINK11.17816324
55PIM11.09067970
56ERBB31.06786181
57NTRK21.06529508
58PRKCE1.01432587
59PIM20.98243599
60NTRK10.97512002
61NME10.95940380
62CDK40.95490841
63INSRR0.94676138
64LMTK20.92466823
65MKNK20.90396467
66EPHB10.89886028
67CSF1R0.87546961
68BRAF0.84725664
69IRAK40.84153786
70STK240.83832649
71MAP3K130.79362322
72EPHA30.79017235
73TRPM70.78037008
74LIMK10.77093211
75MST40.76629538
76MAPK70.75056542
77CAMKK20.72330172
78GRK70.71753542
79PDK10.71490584
80TAOK10.71291927
81STK390.70884700
82MAP2K40.70755945
83MAP2K30.70454898
84FGFR20.69321989
85IRAK20.68693324
86MARK10.67569045
87ADRBK10.67290281
88FES0.67253031
89CHUK0.67052888
90ERN10.66629494
91CAMK2A0.66000839
92JAK20.65806054
93KDR0.65212934
94NEK60.64769273
95CDK50.64059586
96STK100.64031780
97PAK60.63454615
98PRKCG0.62076269
99MARK20.61789933
100FYN0.60047045
101PRKCQ0.58703921
102WNK40.57437592
103DAPK20.55306382
104NUAK10.54154054
105FRK0.53038463
106KSR20.52895002
107MAP3K20.52472642
108PIK3CG0.52170277
109STK380.51914524
110CDK30.51832844
111RPS6KA20.51785467
112PKN10.51193420
113SGK30.50730278
114RPS6KA60.49946443
115RAF10.49686751
116MAPK110.48802193
117CDK60.48160413
118FGR0.47966315
119GRK10.47770799
120RPS6KL10.47006278
121RPS6KC10.47006278
122MAP3K70.46345946
123DYRK20.45307072
124FER0.44945717
125PRKD20.44671638
126MST1R0.44230860
127EIF2AK20.42971091
128TEC0.42551639
129IGF1R0.42045609
130INSR0.42001072
131JAK30.41666985
132PRKACA0.41611256
133MAPKAPK20.41414497
134ZAK0.41137399
135PTK2B0.41047559
136ACVR1B0.39492117
137PIK3CA0.38811396
138MAP2K60.38601417
139TGFBR20.38199573
140MAP3K90.36935589
141ABL10.36656507
142MAPK120.36122242
143UHMK10.36035032
144MAP3K40.35919726
145SGK10.34976753
146RET0.34467938
147MAPK40.34217571
148MAPKAPK30.33873857
149MAPK30.33567499
150MATK0.32688672
151RPS6KA10.32176414
152CAMK2G0.31667182
153MAP2K10.31485654
154TAOK30.31339891
155OXSR10.31085423
156PRKCD0.30396939
157PRKCH0.30135956
158DYRK1A0.29974028
159ROCK10.29081346
160CAMKK10.27336140
161MAP3K30.27057412

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.77010343
2Nicotine addiction_Homo sapiens_hsa050332.80187024
3Taste transduction_Homo sapiens_hsa047422.61191338
4Leishmaniasis_Homo sapiens_hsa051402.49900822
5B cell receptor signaling pathway_Homo sapiens_hsa046622.42363914
6Osteoclast differentiation_Homo sapiens_hsa043802.39700627
7Synaptic vesicle cycle_Homo sapiens_hsa047212.38504151
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.38241360
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.18610024
10Serotonergic synapse_Homo sapiens_hsa047262.12604384
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.06004646
12Olfactory transduction_Homo sapiens_hsa047402.05957858
13Morphine addiction_Homo sapiens_hsa050322.03166670
14* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.99741803
15Glutamatergic synapse_Homo sapiens_hsa047241.99351561
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.98055035
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.94401099
18Antigen processing and presentation_Homo sapiens_hsa046121.93380796
19Measles_Homo sapiens_hsa051621.91078916
20Malaria_Homo sapiens_hsa051441.90517638
21Collecting duct acid secretion_Homo sapiens_hsa049661.84723575
22Circadian entrainment_Homo sapiens_hsa047131.78557680
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.73290295
24Insulin secretion_Homo sapiens_hsa049111.68493082
25GABAergic synapse_Homo sapiens_hsa047271.64403901
26Phototransduction_Homo sapiens_hsa047441.62763095
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.57487782
28TNF signaling pathway_Homo sapiens_hsa046681.55904000
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.54620815
30Staphylococcus aureus infection_Homo sapiens_hsa051501.52973175
31Allograft rejection_Homo sapiens_hsa053301.52498176
32Salivary secretion_Homo sapiens_hsa049701.50992469
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.50402851
34Autoimmune thyroid disease_Homo sapiens_hsa053201.46797802
35Dopaminergic synapse_Homo sapiens_hsa047281.44588065
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.44076130
37Herpes simplex infection_Homo sapiens_hsa051681.43949159
38Acute myeloid leukemia_Homo sapiens_hsa052211.43162561
39Cholinergic synapse_Homo sapiens_hsa047251.42891018
40Regulation of autophagy_Homo sapiens_hsa041401.42234672
41Rheumatoid arthritis_Homo sapiens_hsa053231.40853215
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38575435
43Calcium signaling pathway_Homo sapiens_hsa040201.37141956
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36276553
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.35958254
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35501365
47Long-term potentiation_Homo sapiens_hsa047201.33516310
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.32554728
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30669217
50Tuberculosis_Homo sapiens_hsa051521.28190524
51Asthma_Homo sapiens_hsa053101.27989422
52Melanoma_Homo sapiens_hsa052181.26554680
53Platelet activation_Homo sapiens_hsa046111.25175619
54Viral myocarditis_Homo sapiens_hsa054161.25049505
55Non-small cell lung cancer_Homo sapiens_hsa052231.24431247
56Axon guidance_Homo sapiens_hsa043601.22726254
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21620157
58Long-term depression_Homo sapiens_hsa047301.20755319
59Graft-versus-host disease_Homo sapiens_hsa053321.20615804
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19474835
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17138186
62Toxoplasmosis_Homo sapiens_hsa051451.16616057
63Legionellosis_Homo sapiens_hsa051341.15083995
64Apoptosis_Homo sapiens_hsa042101.13780578
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13155003
66African trypanosomiasis_Homo sapiens_hsa051431.12802159
67Leukocyte transendothelial migration_Homo sapiens_hsa046701.05211534
68Amphetamine addiction_Homo sapiens_hsa050311.03553181
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03424578
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.01811788
71Type I diabetes mellitus_Homo sapiens_hsa049401.00653398
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99000563
73Mineral absorption_Homo sapiens_hsa049780.95729202
74Influenza A_Homo sapiens_hsa051640.95072837
75Phagosome_Homo sapiens_hsa041450.91508651
76Hepatitis B_Homo sapiens_hsa051610.90790010
77Oxytocin signaling pathway_Homo sapiens_hsa049210.90658915
78Renin-angiotensin system_Homo sapiens_hsa046140.90484272
79Shigellosis_Homo sapiens_hsa051310.90228091
80Renin secretion_Homo sapiens_hsa049240.89863777
81ErbB signaling pathway_Homo sapiens_hsa040120.88997505
82Ras signaling pathway_Homo sapiens_hsa040140.87701763
83Cardiac muscle contraction_Homo sapiens_hsa042600.86120043
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.85216550
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84868518
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84476399
87Oxidative phosphorylation_Homo sapiens_hsa001900.83845880
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83725857
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82137512
90Hepatitis C_Homo sapiens_hsa051600.80625143
91Viral carcinogenesis_Homo sapiens_hsa052030.80033353
92Gastric acid secretion_Homo sapiens_hsa049710.79650340
93Prolactin signaling pathway_Homo sapiens_hsa049170.78811504
94Hematopoietic cell lineage_Homo sapiens_hsa046400.77906930
95Melanogenesis_Homo sapiens_hsa049160.75590192
96cAMP signaling pathway_Homo sapiens_hsa040240.75267167
97Choline metabolism in cancer_Homo sapiens_hsa052310.75162442
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75159538
99Pertussis_Homo sapiens_hsa051330.71603460
100GnRH signaling pathway_Homo sapiens_hsa049120.69902967
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69650532
102Chemokine signaling pathway_Homo sapiens_hsa040620.69584164
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68936787
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67387338
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.67131451
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66503032
107Alzheimers disease_Homo sapiens_hsa050100.66473455
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65682906
109Glioma_Homo sapiens_hsa052140.64955313
110Endocytosis_Homo sapiens_hsa041440.63981570
111Rap1 signaling pathway_Homo sapiens_hsa040150.63668273
112Salmonella infection_Homo sapiens_hsa051320.63653646
113Pancreatic secretion_Homo sapiens_hsa049720.62548466
114Vibrio cholerae infection_Homo sapiens_hsa051100.60757780
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60437097
116Ether lipid metabolism_Homo sapiens_hsa005650.57803036
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.57146092
118Sphingolipid metabolism_Homo sapiens_hsa006000.57100819
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.56826084
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55555478
121HTLV-I infection_Homo sapiens_hsa051660.55413685
122Nitrogen metabolism_Homo sapiens_hsa009100.55223834
123Insulin resistance_Homo sapiens_hsa049310.55213367
124Other glycan degradation_Homo sapiens_hsa005110.54544960
125MAPK signaling pathway_Homo sapiens_hsa040100.54429777
126Inositol phosphate metabolism_Homo sapiens_hsa005620.54150325
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.53594557
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.52623065
129Dorso-ventral axis formation_Homo sapiens_hsa043200.52276278
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.52163621
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49563101
132Epstein-Barr virus infection_Homo sapiens_hsa051690.48169490
133FoxO signaling pathway_Homo sapiens_hsa040680.48026087
134Linoleic acid metabolism_Homo sapiens_hsa005910.47971592
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47544084
136Lysosome_Homo sapiens_hsa041420.47369315
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46125229
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45920614
139Thyroid hormone synthesis_Homo sapiens_hsa049180.42823434
140Glycerolipid metabolism_Homo sapiens_hsa005610.42634676
141T cell receptor signaling pathway_Homo sapiens_hsa046600.42444319
142Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42321413
143Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41835568
144Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41343253
145Gap junction_Homo sapiens_hsa045400.41047356
146Hedgehog signaling pathway_Homo sapiens_hsa043400.40245158
147Neurotrophin signaling pathway_Homo sapiens_hsa047220.39515583
148Arachidonic acid metabolism_Homo sapiens_hsa005900.38705284
149Type II diabetes mellitus_Homo sapiens_hsa049300.38205479
150Pancreatic cancer_Homo sapiens_hsa052120.38192056
151Chronic myeloid leukemia_Homo sapiens_hsa052200.37924224
152Endometrial cancer_Homo sapiens_hsa052130.37789814
153Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37274852
154VEGF signaling pathway_Homo sapiens_hsa043700.36078369
155Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35958908
156ABC transporters_Homo sapiens_hsa020100.32954696
157Colorectal cancer_Homo sapiens_hsa052100.30887739
158Notch signaling pathway_Homo sapiens_hsa043300.29786025
159Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26818296
160Prostate cancer_Homo sapiens_hsa052150.25002408

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