PTER

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.85573505
2L-phenylalanine catabolic process (GO:0006559)6.85573505
3L-phenylalanine metabolic process (GO:0006558)6.55458715
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.55458715
5aromatic amino acid family catabolic process (GO:0009074)6.18515846
6glyoxylate metabolic process (GO:0046487)6.03947339
7lysine catabolic process (GO:0006554)5.95311991
8lysine metabolic process (GO:0006553)5.95311991
9cysteine metabolic process (GO:0006534)5.88052220
10drug transmembrane transport (GO:0006855)5.86824662
11urate metabolic process (GO:0046415)5.77936141
12indole-containing compound catabolic process (GO:0042436)5.53694213
13indolalkylamine catabolic process (GO:0046218)5.53694213
14tryptophan catabolic process (GO:0006569)5.53694213
15tryptophan metabolic process (GO:0006568)5.15545712
16synaptic vesicle maturation (GO:0016188)5.14294614
17kynurenine metabolic process (GO:0070189)5.08494252
18bile acid biosynthetic process (GO:0006699)4.89745891
19drug catabolic process (GO:0042737)4.80656943
20drug transport (GO:0015893)4.80527713
21cellular ketone body metabolic process (GO:0046950)4.79319984
22serine family amino acid catabolic process (GO:0009071)4.62372346
23short-chain fatty acid metabolic process (GO:0046459)4.56615189
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.56207664
25aspartate family amino acid catabolic process (GO:0009068)4.55815911
26glutamate metabolic process (GO:0006536)4.47981041
27homocysteine metabolic process (GO:0050667)4.46301655
28aromatic amino acid family metabolic process (GO:0009072)4.43703582
29sulfur amino acid catabolic process (GO:0000098)4.42475322
30exogenous drug catabolic process (GO:0042738)4.36520755
31amino-acid betaine metabolic process (GO:0006577)4.28304557
32phosphate ion transport (GO:0006817)4.26252206
33cellular modified amino acid catabolic process (GO:0042219)4.25553227
34alpha-amino acid catabolic process (GO:1901606)4.24870819
35synaptic vesicle docking involved in exocytosis (GO:0016081)4.23294750
36serine family amino acid metabolic process (GO:0009069)4.17278018
37ketone body metabolic process (GO:1902224)4.16999914
38alpha-linolenic acid metabolic process (GO:0036109)4.15827489
39phosphate ion transmembrane transport (GO:0035435)4.14610896
40response to mercury ion (GO:0046689)4.08928241
41cellular amino acid catabolic process (GO:0009063)4.07926683
42glutamate secretion (GO:0014047)4.03767817
43dicarboxylic acid biosynthetic process (GO:0043650)4.03516022
44bile acid metabolic process (GO:0008206)3.98786227
45acetyl-CoA metabolic process (GO:0006084)3.96328005
46urea metabolic process (GO:0019627)3.94762122
47urea cycle (GO:0000050)3.94762122
48tyrosine metabolic process (GO:0006570)3.90718637
49triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.90654666
50serine family amino acid biosynthetic process (GO:0009070)3.88638988
51oxaloacetate metabolic process (GO:0006107)3.83886154
52organic cation transport (GO:0015695)3.83329796
53indolalkylamine metabolic process (GO:0006586)3.82910191
54amine catabolic process (GO:0009310)3.76124457
55cellular biogenic amine catabolic process (GO:0042402)3.76124457
56benzene-containing compound metabolic process (GO:0042537)3.75182622
57coenzyme catabolic process (GO:0009109)3.69944966
58nitrogen cycle metabolic process (GO:0071941)3.69520509
592-oxoglutarate metabolic process (GO:0006103)3.66851915
60aldehyde catabolic process (GO:0046185)3.62095285
61organic acid catabolic process (GO:0016054)3.58170609
62carboxylic acid catabolic process (GO:0046395)3.58170609
63proteasome assembly (GO:0043248)3.57857658
64negative regulation of fibrinolysis (GO:0051918)3.53513604
65cellular glucuronidation (GO:0052695)3.53238381
66protein carboxylation (GO:0018214)3.51181695
67peptidyl-glutamic acid carboxylation (GO:0017187)3.51181695
68fatty acid beta-oxidation (GO:0006635)3.51069717
69fatty acid oxidation (GO:0019395)3.47270890
70pteridine-containing compound biosynthetic process (GO:0042559)3.46400848
71indole-containing compound metabolic process (GO:0042430)3.45521403
72high-density lipoprotein particle remodeling (GO:0034375)3.45095965
73synaptic vesicle exocytosis (GO:0016079)3.44972757
74quaternary ammonium group transport (GO:0015697)3.44810146
75regulation of fibrinolysis (GO:0051917)3.43545598
76branched-chain amino acid metabolic process (GO:0009081)3.42399383
77nonribosomal peptide biosynthetic process (GO:0019184)3.42294837
78lipid oxidation (GO:0034440)3.41428232
79glucuronate metabolic process (GO:0019585)3.38494170
80uronic acid metabolic process (GO:0006063)3.38494170
81deoxyribonucleotide biosynthetic process (GO:0009263)3.37384078
82complement activation, alternative pathway (GO:0006957)3.36232280
83monocarboxylic acid catabolic process (GO:0072329)3.36157412
84folic acid-containing compound biosynthetic process (GO:0009396)3.32819101
85branched-chain amino acid catabolic process (GO:0009083)3.32330437
86regulation of protein activation cascade (GO:2000257)3.31322948
87carnitine metabolic process (GO:0009437)3.31184011
88fatty acid catabolic process (GO:0009062)3.30864282
89ethanol oxidation (GO:0006069)3.28836234
90glutathione biosynthetic process (GO:0006750)3.28416227
91deoxyribose phosphate biosynthetic process (GO:0046385)3.27592023
922-deoxyribonucleotide biosynthetic process (GO:0009265)3.27592023
93very long-chain fatty acid metabolic process (GO:0000038)3.26650701
94negative regulation of cholesterol transport (GO:0032375)3.22404354
95negative regulation of sterol transport (GO:0032372)3.22404354
96aminoglycoside antibiotic metabolic process (GO:0030647)3.20345913
97valine metabolic process (GO:0006573)3.19097033
98drug metabolic process (GO:0017144)3.18452388
99flavonoid metabolic process (GO:0009812)3.18437719
100regulation of synaptic vesicle exocytosis (GO:2000300)3.16165098
101heme transport (GO:0015886)3.14105549
102glycine metabolic process (GO:0006544)3.13657070
103sodium ion export (GO:0071436)3.12633002
104small molecule catabolic process (GO:0044282)3.12135214
105deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.09472105
106arginine metabolic process (GO:0006525)3.08530532
107dicarboxylic acid metabolic process (GO:0043648)3.07078263
108regulation of complement activation (GO:0030449)3.07060631
109triglyceride homeostasis (GO:0070328)3.07035721
110acylglycerol homeostasis (GO:0055090)3.07035721
111regulation of bile acid biosynthetic process (GO:0070857)3.06316941
112glutathione derivative metabolic process (GO:1901685)3.05769967
113glutathione derivative biosynthetic process (GO:1901687)3.05769967
114cellular potassium ion homeostasis (GO:0030007)3.05117263
115response to phenylpropanoid (GO:0080184)3.04041280
116neurotransmitter secretion (GO:0007269)3.02862378
117water-soluble vitamin biosynthetic process (GO:0042364)3.00880125
118sleep (GO:0030431)3.00614208
119regulation of oxidative phosphorylation (GO:0002082)2.90762118
120mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.89514811
121nucleobase-containing small molecule interconversion (GO:0015949)2.89078709
122regulation of short-term neuronal synaptic plasticity (GO:0048172)2.83203242
123regulation of cellular amino acid metabolic process (GO:0006521)2.82127108
124regulation of synaptic vesicle transport (GO:1902803)2.81747671
125tricarboxylic acid cycle (GO:0006099)2.79656360
126ADP metabolic process (GO:0046031)2.77581269
127positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.76828082
128negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.75515642
129maturation of 5.8S rRNA (GO:0000460)2.73653316
130positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.66213801
131energy coupled proton transport, down electrochemical gradient (GO:0015985)2.66207253
132ATP synthesis coupled proton transport (GO:0015986)2.66207253
133tetrahydrofolate metabolic process (GO:0046653)2.64300140
134NADH metabolic process (GO:0006734)2.62808037
135deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.61861963
136pseudouridine synthesis (GO:0001522)2.58063460
137dicarboxylic acid catabolic process (GO:0043649)2.57321653
138respiratory chain complex IV assembly (GO:0008535)2.57105372
139regulation of isotype switching to IgG isotypes (GO:0048302)2.56175781
140ribosome assembly (GO:0042255)2.54965797
141mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.54709732
142purine nucleoside diphosphate metabolic process (GO:0009135)2.53886999
143purine ribonucleoside diphosphate metabolic process (GO:0009179)2.53886999
144pteridine-containing compound metabolic process (GO:0042558)2.53554080
145membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.53235368
146nucleotide transmembrane transport (GO:1901679)2.52780073
147regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.52490276
148respiratory electron transport chain (GO:0022904)2.52397601
149vesicle docking involved in exocytosis (GO:0006904)2.48108706
150DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.48043521
151L-methionine salvage (GO:0071267)2.46981997
152L-methionine biosynthetic process (GO:0071265)2.46981997
153amino acid salvage (GO:0043102)2.46981997
154electron transport chain (GO:0022900)2.45071582
155negative regulation of ligase activity (GO:0051352)2.45060778
156negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.45060778
157response to interferon-beta (GO:0035456)2.44121363
158signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.43566551
159intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.43566551
160regulation of B cell receptor signaling pathway (GO:0050855)2.43510845
161neurotransmitter uptake (GO:0001504)2.43382700
162polyketide metabolic process (GO:0030638)2.43066216
163doxorubicin metabolic process (GO:0044598)2.43066216
164daunorubicin metabolic process (GO:0044597)2.43066216
165L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.42623987
166signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.41683090
167signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.41683090
168signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.41683090
169positive regulation of vesicle fusion (GO:0031340)2.41277944
170nucleoside diphosphate biosynthetic process (GO:0009133)2.41079827
171hepatocyte apoptotic process (GO:0097284)2.40664987
172positive regulation of prostaglandin secretion (GO:0032308)2.39420101
173ribonucleoside diphosphate metabolic process (GO:0009185)2.39150882
174detection of calcium ion (GO:0005513)2.38817042
175positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.38427332
176oxidative phosphorylation (GO:0006119)2.37907760
177DNA deamination (GO:0045006)2.36661057
178protoporphyrinogen IX biosynthetic process (GO:0006782)2.35387197
179ATP hydrolysis coupled proton transport (GO:0015991)2.35346138
180energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.35346138
181positive regulation of ligase activity (GO:0051351)2.34882411
182anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.34028898
183neurotransmitter transport (GO:0006836)2.33158896
184regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.33132124
185signal transduction involved in DNA integrity checkpoint (GO:0072401)2.31977534
186signal transduction involved in DNA damage checkpoint (GO:0072422)2.31977534
187regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.31242354
188regulation of cellular amine metabolic process (GO:0033238)2.29362027
189chaperone-mediated protein transport (GO:0072321)2.29122394
190vesicle docking (GO:0048278)2.28658234
191cytochrome complex assembly (GO:0017004)2.27039811

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.61862595
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.50826931
3E2F7_22180533_ChIP-Seq_HELA_Human4.85930561
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.38312869
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.28042128
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.05229918
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.99138563
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.79894741
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.42654109
10IRF8_22096565_ChIP-ChIP_GC-B_Human3.41055166
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.20377757
12ELF1_17652178_ChIP-ChIP_JURKAT_Human3.13905529
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.12303544
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.04825536
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.95977826
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.91951146
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.81647413
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.79060529
19GBX2_23144817_ChIP-Seq_PC3_Human2.59007537
20CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.47383779
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.33843518
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.25771959
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16550796
24CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.07088920
25VDR_23849224_ChIP-Seq_CD4+_Human1.99923788
26EZH2_22144423_ChIP-Seq_EOC_Human1.97116711
27* ELK1_19687146_ChIP-ChIP_HELA_Human1.95243948
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94830860
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.92854567
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.92284180
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.92205305
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.87108913
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77573097
34* FOXP3_21729870_ChIP-Seq_TREG_Human1.77415259
35ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.71532165
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70800595
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70331495
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68790206
39TAF15_26573619_Chip-Seq_HEK293_Human1.67484293
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66221967
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.66125071
42SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.66018382
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.63399928
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61710325
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61498726
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59532584
47TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.57838943
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54301823
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51731393
50MTF2_20144788_ChIP-Seq_MESCs_Mouse1.49978816
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.49665846
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48260477
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46304748
54MYC_18555785_ChIP-Seq_MESCs_Mouse1.43753021
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42202244
56JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40717273
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40376732
58FOXA2_19822575_ChIP-Seq_HepG2_Human1.39534220
59HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.39499181
60VDR_22108803_ChIP-Seq_LS180_Human1.38777781
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38540636
62SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.37534904
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.34789993
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.34789993
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34567527
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.33226352
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32792936
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32321359
69MYB_26560356_Chip-Seq_TH2_Human1.32150962
70GATA3_26560356_Chip-Seq_TH2_Human1.30670963
71SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28232445
72SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26540262
73MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26066381
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26052643
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26052643
76HTT_18923047_ChIP-ChIP_STHdh_Human1.25934371
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24827673
78JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24427383
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23822591
80EED_16625203_ChIP-ChIP_MESCs_Mouse1.22081306
81* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21443586
82AR_21909140_ChIP-Seq_LNCAP_Human1.20185810
83HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19617032
84ELF5_23300383_ChIP-Seq_T47D_Human1.18170894
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17673873
86SALL4_22934838_ChIP-ChIP_CD34+_Human1.17321532
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17038961
88* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15461891
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15004057
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.13847468
91GATA1_22025678_ChIP-Seq_K562_Human1.13209327
92* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13200487
93DCP1A_22483619_ChIP-Seq_HELA_Human1.13064183
94* P300_19829295_ChIP-Seq_ESCs_Human1.12530000
95HNF4A_19822575_ChIP-Seq_HepG2_Human1.11798089
96SMAD4_21799915_ChIP-Seq_A2780_Human1.10593085
97* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10275058
98SCL_19346495_ChIP-Seq_HPC-7_Human1.10243483
99DROSHA_22980978_ChIP-Seq_HELA_Human1.09982031
100* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08012637
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07839824
102SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07663359
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07217888
104CRX_20693478_ChIP-Seq_RETINA_Mouse1.06632906
105SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05693065
106MYC_19030024_ChIP-ChIP_MESCs_Mouse1.05454795
107SPI1_23547873_ChIP-Seq_NB4_Human1.04505003
108* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04440856
109MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03316990
110AR_21572438_ChIP-Seq_LNCaP_Human1.02497164
111* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.01951248
112REST_21632747_ChIP-Seq_MESCs_Mouse1.01545941
113* SOX2_18555785_Chip-Seq_ESCs_Mouse1.01226644
114STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01113334
115* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00703914
116TFEB_21752829_ChIP-Seq_HELA_Human1.00605269
117* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99958366
118THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99413027
119GATA3_26560356_Chip-Seq_TH1_Human0.99315756
120* KLF4_18555785_Chip-Seq_ESCs_Mouse0.98193231
121EZH2_27294783_Chip-Seq_ESCs_Mouse0.98005289
122GATA2_21666600_ChIP-Seq_HMVEC_Human0.97896938
123* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97103514
124FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96956838
125FOXA1_25329375_ChIP-Seq_VCAP_Human0.96956838
126* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96916537
127PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96412278
128RARB_27405468_Chip-Seq_BRAIN_Mouse0.96108830
129LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95632928
130NFE2_27457419_Chip-Seq_LIVER_Mouse0.94335534
131REST_18959480_ChIP-ChIP_MESCs_Mouse0.94014981
132STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93964929
133* CBP_21632823_ChIP-Seq_H3396_Human0.93623711
134RXR_22108803_ChIP-Seq_LS180_Human0.93596442
135SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93213175
136GATA3_27048872_Chip-Seq_THYMUS_Human0.92919233
137* STAT3_18555785_Chip-Seq_ESCs_Mouse0.92827455
138* OCT4_18555785_Chip-Seq_ESCs_Mouse0.92599419
139EZH2_27304074_Chip-Seq_ESCs_Mouse0.92320408
140* CTCF_18555785_Chip-Seq_ESCs_Mouse0.92283319
141STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.92200027
142TP53_22573176_ChIP-Seq_HFKS_Human0.91623067
143AR_25329375_ChIP-Seq_VCAP_Human0.90908001
144E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90472297
145BCAT_22108803_ChIP-Seq_LS180_Human0.90413167
146SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90393236
147NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90260532
148RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90219169
149* E2F1_18555785_Chip-Seq_ESCs_Mouse0.90031308
150ESR2_21235772_ChIP-Seq_MCF-7_Human0.89766352
151MYC_19079543_ChIP-ChIP_MESCs_Mouse0.89517592
152* GATA6_21074721_ChIP-Seq_CACO-2_Human0.89311972
153RBPJ_21746931_ChIP-Seq_IB4_Human0.89291762
154OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88473598
155UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88407555
156SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88065533
157* NMYC_18555785_Chip-Seq_ESCs_Mouse0.87638108
158FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87442710
159TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86739733
160SMAD3_21741376_ChIP-Seq_EPCs_Human0.85355333
161ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85228926
162NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.84906608
163ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84751458
164PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84571767
165SMAD4_21741376_ChIP-Seq_EPCs_Human0.83539960
166POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83278368
167AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80889161
168CLOCK_20551151_ChIP-Seq_293T_Human0.80516812
169ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80427226
170SOX2_21211035_ChIP-Seq_LN229_Gbm0.80105060
171PRDM14_20953172_ChIP-Seq_ESCs_Human0.79942431
172THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79863087
173SMAD3_21741376_ChIP-Seq_HESCs_Human0.79534385
174SMAD4_21741376_ChIP-Seq_HESCs_Human0.78977075
175AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78786039
176CDX2_20551321_ChIP-Seq_CACO-2_Human0.78760427
177CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.76258095
178TP53_18474530_ChIP-ChIP_U2OS_Human0.76137022
179ER_23166858_ChIP-Seq_MCF-7_Human0.75601247
180ARNT_22903824_ChIP-Seq_MCF-7_Human0.75498826
181NR3C1_21868756_ChIP-Seq_MCF10A_Human0.75054218
182EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.74566899
183ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74248523
184TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.73513673
185* NANOG_19829295_ChIP-Seq_ESCs_Human0.72884726
186* SOX2_19829295_ChIP-Seq_ESCs_Human0.72884726
187KDM2B_26808549_Chip-Seq_REH_Human0.72181264
188EP300_21415370_ChIP-Seq_HL-1_Mouse0.71793713
189KLF5_20875108_ChIP-Seq_MESCs_Mouse0.70777888
190STAT3_23295773_ChIP-Seq_U87_Human0.70226452

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.70848495
2MP0002139_abnormal_hepatobiliary_system6.78515450
3MP0005085_abnormal_gallbladder_physiolo4.82132909
4MP0005365_abnormal_bile_salt4.64954337
5MP0008875_abnormal_xenobiotic_pharmacok4.37283661
6MP0005332_abnormal_amino_acid3.68140279
7MP0003195_calcinosis3.56183128
8MP0004019_abnormal_vitamin_homeostasis3.19199035
9MP0003252_abnormal_bile_duct3.12186336
10MP0003806_abnormal_nucleotide_metabolis3.09528089
11MP0004043_abnormal_pH_regulation2.84366759
12MP0010329_abnormal_lipoprotein_level2.43458116
13MP0002138_abnormal_hepatobiliary_system2.30935408
14MP0004859_abnormal_synaptic_plasticity2.21705934
15MP0009643_abnormal_urine_homeostasis2.05376036
16MP0008057_abnormal_DNA_replication1.96472642
17MP0003880_abnormal_central_pattern1.95655013
18MP0001666_abnormal_nutrient_absorption1.88532171
19MP0005636_abnormal_mineral_homeostasis1.83919133
20MP0001765_abnormal_ion_homeostasis1.79943542
21MP0003329_amyloid_beta_deposits1.78809446
22MP0005083_abnormal_biliary_tract1.77936296
23MP0001835_abnormal_antigen_presentation1.75657782
24MP0005584_abnormal_enzyme/coenzyme_acti1.72788954
25MP0002118_abnormal_lipid_homeostasis1.71655615
26MP0002006_tumorigenesis1.70979824
27MP0003191_abnormal_cellular_cholesterol1.64746648
28MP0009840_abnormal_foam_cell1.58656648
29MP0000569_abnormal_digit_pigmentation1.56610095
30MP0002148_abnormal_hypersensitivity_rea1.53219639
31MP0010094_abnormal_chromosome_stability1.51185583
32MP0005319_abnormal_enzyme/_coenzyme1.50808574
33MP0000685_abnormal_immune_system1.43409742
34MP0002876_abnormal_thyroid_physiology1.42669130
35MP0008058_abnormal_DNA_repair1.42353818
36MP0005464_abnormal_platelet_physiology1.40821635
37MP0001764_abnormal_homeostasis1.37857237
38MP0003763_abnormal_thymus_physiology1.37525190
39MP0001756_abnormal_urination1.37085253
40MP0000604_amyloidosis1.36718811
41MP0002166_altered_tumor_susceptibility1.34565438
42MP0005451_abnormal_body_composition1.33514086
43MP0003866_abnormal_defecation1.32800834
44MP0010234_abnormal_vibrissa_follicle1.30061530
45MP0000609_abnormal_liver_physiology1.29468882
46MP0005000_abnormal_immune_tolerance1.27817619
47MP0005165_increased_susceptibility_to1.27801891
48MP0005671_abnormal_response_to1.27593762
49MP0003186_abnormal_redox_activity1.26986981
50MP0002396_abnormal_hematopoietic_system1.25844421
51MP0003868_abnormal_feces_composition1.24597819
52MP0010386_abnormal_urinary_bladder1.23688396
53MP0003635_abnormal_synaptic_transmissio1.21509657
54MP0009785_altered_susceptibility_to1.21385070
55MP0002136_abnormal_kidney_physiology1.20131400
56MP0005535_abnormal_body_temperature1.17415924
57MP0002064_seizures1.15014358
58MP0005410_abnormal_fertilization1.14585416
59MP0009745_abnormal_behavioral_response1.14230571
60MP0006036_abnormal_mitochondrial_physio1.13637926
61MP0008569_lethality_at_weaning1.12747999
62MP0003045_fibrosis1.11879878
63MP0002693_abnormal_pancreas_physiology1.11306048
64MP0003786_premature_aging1.11292887
65MP0004885_abnormal_endolymph1.09975930
66MP0005084_abnormal_gallbladder_morpholo1.09747075
67MP0004270_analgesia1.09249012
68MP0002063_abnormal_learning/memory/cond1.06521266
69MP0001800_abnormal_humoral_immune1.04814272
70MP0002398_abnormal_bone_marrow1.04594423
71MP0003690_abnormal_glial_cell1.02991308
72MP0004145_abnormal_muscle_electrophysio1.02577675
73MP0002452_abnormal_antigen_presenting1.02226813
74MP0005423_abnormal_somatic_nervous0.99507094
75MP0002420_abnormal_adaptive_immunity0.99012483
76MP0002723_abnormal_immune_serum0.98761378
77MP0001819_abnormal_immune_cell0.96630018
78MP0003011_delayed_dark_adaptation0.95307945
79MP0008007_abnormal_cellular_replicative0.95031061
80MP0000920_abnormal_myelination0.92646811
81MP0002736_abnormal_nociception_after0.91221958
82MP0001968_abnormal_touch/_nociception0.91190990
83MP0001845_abnormal_inflammatory_respons0.90561545
84MP0004957_abnormal_blastocyst_morpholog0.89896180
85MP0008873_increased_physiological_sensi0.88080795
86MP0000230_abnormal_systemic_arterial0.87678453
87MP0000689_abnormal_spleen_morphology0.87036849
88MP0008877_abnormal_DNA_methylation0.86916860
89MP0001440_abnormal_grooming_behavior0.86745366
90MP0001970_abnormal_pain_threshold0.86144379
91MP0003111_abnormal_nucleus_morphology0.85160181
92MP0004782_abnormal_surfactant_physiolog0.84555112
93MP0005058_abnormal_lysosome_morphology0.84335261
94MP0004947_skin_inflammation0.83377421
95MP0010678_abnormal_skin_adnexa0.83178562
96MP0001881_abnormal_mammary_gland0.82874676
97MP0000716_abnormal_immune_system0.80798691
98MP0003075_altered_response_to0.80650659
99MP0001986_abnormal_taste_sensitivity0.80096375
100MP0002572_abnormal_emotion/affect_behav0.79798197
101MP0003633_abnormal_nervous_system0.79699827
102MP0001790_abnormal_immune_system0.79295774
103MP0005387_immune_system_phenotype0.79295774
104MP0001661_extended_life_span0.78344948
105MP0001486_abnormal_startle_reflex0.78303198
106MP0008874_decreased_physiological_sensi0.76111827
107MP0009642_abnormal_blood_homeostasis0.76033338
108MP0002272_abnormal_nervous_system0.75156133
109MP0009697_abnormal_copulation0.74962923
110MP0002837_dystrophic_cardiac_calcinosis0.74411792
111MP0002822_catalepsy0.71668525
112MP0008872_abnormal_physiological_respon0.68642364
113MP0003631_nervous_system_phenotype0.67043515
114MP0009780_abnormal_chondrocyte_physiolo0.66620728
115MP0002078_abnormal_glucose_homeostasis0.66516327
116MP0009046_muscle_twitch0.66049257
117MP0004147_increased_porphyrin_level0.65922565
118MP0006035_abnormal_mitochondrial_morpho0.65871257
119MP0000538_abnormal_urinary_bladder0.65699907
120MP0003656_abnormal_erythrocyte_physiolo0.64146977
121MP0003638_abnormal_response/metabolism_0.63337455
122MP0000598_abnormal_liver_morphology0.63091351
123MP0004142_abnormal_muscle_tone0.62946245
124MP0003879_abnormal_hair_cell0.62941090
125MP0001958_emphysema0.62641221
126MP0009764_decreased_sensitivity_to0.62093667
127MP0002067_abnormal_sensory_capabilities0.61933346
128MP0005376_homeostasis/metabolism_phenot0.61293176
129MP0002168_other_aberrant_phenotype0.61268282
130MP0002735_abnormal_chemical_nociception0.60829478
131MP0002069_abnormal_eating/drinking_beha0.60733365
132MP0005647_abnormal_sex_gland0.57859805
133MP0001501_abnormal_sleep_pattern0.56985487
134MP0002928_abnormal_bile_duct0.54900870
135MP0002229_neurodegeneration0.54494586
136MP0005646_abnormal_pituitary_gland0.54286057
137MP0001177_atelectasis0.54062790
138MP0008961_abnormal_basal_metabolism0.53761782
139MP0005551_abnormal_eye_electrophysiolog0.52149963
140MP0002066_abnormal_motor_capabilities/c0.51821496
141MP0003172_abnormal_lysosome_physiology0.51127611
142MP0001905_abnormal_dopamine_level0.50976761
143MP0008469_abnormal_protein_level0.50881816
144MP0005166_decreased_susceptibility_to0.50708836
145MP0005595_abnormal_vascular_smooth0.50440909
146MP0002734_abnormal_mechanical_nocicepti0.50004937
147MP0002971_abnormal_brown_adipose0.49818065
148MP0000747_muscle_weakness0.48103614

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.54847175
2Gout (HP:0001997)5.06695578
3Intrahepatic cholestasis (HP:0001406)4.80085950
4Abnormality of glutamine family amino acid metabolism (HP:0010902)4.65912128
5Increased circulating renin level (HP:0000848)4.55955059
6Hyperglycinuria (HP:0003108)4.49407664
7Deep venous thrombosis (HP:0002625)4.39416929
8Ketosis (HP:0001946)4.31940586
9Abnormality of serine family amino acid metabolism (HP:0010894)4.26990625
10Abnormality of glycine metabolism (HP:0010895)4.26990625
11Xanthomatosis (HP:0000991)4.23750887
12Hypokalemic alkalosis (HP:0001949)4.14180747
13Metabolic alkalosis (HP:0200114)4.13939262
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.99389473
15Abnormality of aspartate family amino acid metabolism (HP:0010899)3.95164625
16Ketoacidosis (HP:0001993)3.94556868
17Hyperglycinemia (HP:0002154)3.89484897
18Hyperammonemia (HP:0001987)3.83174603
19Abnormality of purine metabolism (HP:0004352)3.78679759
20Hypomagnesemia (HP:0002917)3.74388945
21Hyperactive renin-angiotensin system (HP:0000841)3.72917344
22Proximal tubulopathy (HP:0000114)3.70493340
23Increased purine levels (HP:0004368)3.68346031
24Hyperuricemia (HP:0002149)3.68346031
25Alkalosis (HP:0001948)3.67721514
26Hypobetalipoproteinemia (HP:0003563)3.61236092
27Prolonged partial thromboplastin time (HP:0003645)3.59448896
28Abnormality of sulfur amino acid metabolism (HP:0004339)3.43253521
29Polyuria (HP:0000103)3.41409749
30Delayed CNS myelination (HP:0002188)3.41058863
31Abnormal urine output (HP:0012590)3.37487322
32Abnormality of fatty-acid metabolism (HP:0004359)3.28639037
33Abnormality of nucleobase metabolism (HP:0010932)3.22572456
34Hyperlipoproteinemia (HP:0010980)3.21554656
35Abnormality of chloride homeostasis (HP:0011422)3.17271587
36Abnormality of renal excretion (HP:0011036)3.15773171
37Abnormality of magnesium homeostasis (HP:0004921)3.13493265
38Increased hepatocellular lipid droplets (HP:0006565)3.06967316
39Vascular calcification (HP:0004934)3.05409969
40Generalized aminoaciduria (HP:0002909)3.02524205
41Papilledema (HP:0001085)3.01119342
42Glycosuria (HP:0003076)3.00945068
43Abnormality of urine glucose concentration (HP:0011016)3.00945068
44Metabolic acidosis (HP:0001942)2.97782920
45Febrile seizures (HP:0002373)2.96182877
46Hyperventilation (HP:0002883)2.95154600
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.94315042
48Autoimmune hemolytic anemia (HP:0001890)2.92578446
49Complement deficiency (HP:0004431)2.90407601
50Lipid accumulation in hepatocytes (HP:0006561)2.84830383
51Joint hemorrhage (HP:0005261)2.83624640
52Increased CSF lactate (HP:0002490)2.82950846
53Renal Fanconi syndrome (HP:0001994)2.81462231
54Mitochondrial inheritance (HP:0001427)2.80634633
55Abnormality of B cell number (HP:0010975)2.77723519
56Abnormality of methionine metabolism (HP:0010901)2.76802976
57Lethargy (HP:0001254)2.72960667
58Fat malabsorption (HP:0002630)2.72197084
59Polydipsia (HP:0001959)2.71031636
60Abnormal drinking behavior (HP:0030082)2.71031636
61Cardiovascular calcification (HP:0011915)2.70320054
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.69365202
63Dicarboxylic aciduria (HP:0003215)2.69365202
64Focal seizures (HP:0007359)2.68966996
65Abnormality of serum amino acid levels (HP:0003112)2.66642968
66Increased serum lactate (HP:0002151)2.64252728
67Epidermoid cyst (HP:0200040)2.63962354
68Confusion (HP:0001289)2.63230806
69Hypolipoproteinemia (HP:0010981)2.62717752
70Acute necrotizing encephalopathy (HP:0006965)2.61703574
713-Methylglutaconic aciduria (HP:0003535)2.60639819
72Fatigue (HP:0012378)2.59080869
73Abnormality of renin-angiotensin system (HP:0000847)2.58042819
74Hypoglycemic seizures (HP:0002173)2.56764898
75Vomiting (HP:0002013)2.56120731
76Hyperphosphaturia (HP:0003109)2.55922392
77Hyperaldosteronism (HP:0000859)2.55882512
78B lymphocytopenia (HP:0010976)2.55567846
79Progressive macrocephaly (HP:0004481)2.54810799
80Cerebral edema (HP:0002181)2.54660043
81Delusions (HP:0000746)2.54420359
82Hypoglycemic coma (HP:0001325)2.53875533
83Abnormality of the common coagulation pathway (HP:0010990)2.50012676
84Malnutrition (HP:0004395)2.49110237
85Rickets (HP:0002748)2.46884371
86Hepatocellular necrosis (HP:0001404)2.46167089
87Epileptic encephalopathy (HP:0200134)2.43597128
88Conjugated hyperbilirubinemia (HP:0002908)2.43196660
89Increased intramyocellular lipid droplets (HP:0012240)2.42833774
90Abnormal mitochondria in muscle tissue (HP:0008316)2.38385573
91Enlarged kidneys (HP:0000105)2.38103514
92Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.37262679
93Aplastic anemia (HP:0001915)2.34876860
94Irritability (HP:0000737)2.34412658
95Renal salt wasting (HP:0000127)2.33419151
96Panhypogammaglobulinemia (HP:0003139)2.33364681
97Tetany (HP:0001281)2.32738089
98Sensorimotor neuropathy (HP:0007141)2.32213145
99Palpitations (HP:0001962)2.31855154
100Hydroxyprolinuria (HP:0003080)2.30715380
101Abnormality of proline metabolism (HP:0010907)2.30715380
102Hyperbilirubinemia (HP:0002904)2.28481991
103Neonatal onset (HP:0003623)2.27497684
104Atonic seizures (HP:0010819)2.27314092
105Renal tubular acidosis (HP:0001947)2.27132471
106Hypophosphatemic rickets (HP:0004912)2.25229829
107Microvesicular hepatic steatosis (HP:0001414)2.24830937
108Visual hallucinations (HP:0002367)2.24337662
109Nephrolithiasis (HP:0000787)2.23666433
110Hypoalphalipoproteinemia (HP:0003233)2.23154570
111Severe combined immunodeficiency (HP:0004430)2.22397317
112Abnormal urine phosphate concentration (HP:0012599)2.22130595
113CNS demyelination (HP:0007305)2.21439791
114Impaired vibration sensation in the lower limbs (HP:0002166)2.20442949
115Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.19898790
116Hepatocellular carcinoma (HP:0001402)2.19002876
117Hepatic necrosis (HP:0002605)2.17073663
118Symptomatic seizures (HP:0011145)2.16459122
119Spontaneous abortion (HP:0005268)2.14125611
120Abnormality of T cell physiology (HP:0011840)2.12423537
121Agammaglobulinemia (HP:0004432)2.10508974
122Abnormality of pyrimidine metabolism (HP:0004353)2.10357850
123Methylmalonic aciduria (HP:0012120)2.10267372
124Abnormal delayed hypersensitivity skin test (HP:0002963)2.09788569
125Status epilepticus (HP:0002133)2.09717374
126Acute encephalopathy (HP:0006846)2.09001252
127Tetraplegia (HP:0002445)2.08850925
128Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.08671487
129Decreased activity of mitochondrial respiratory chain (HP:0008972)2.08671487
130Focal motor seizures (HP:0011153)2.08097198
131Mutism (HP:0002300)2.06729234
132Slow saccadic eye movements (HP:0000514)2.06609784
133Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05961748
134Lactic acidosis (HP:0003128)2.04896708
135Hyperinsulinemic hypoglycemia (HP:0000825)2.03055441
136Metaphyseal dysplasia (HP:0100255)2.02975306
137Pancreatic islet-cell hyperplasia (HP:0004510)2.02973513
138Increased muscle lipid content (HP:0009058)2.02858278
139Hypoproteinemia (HP:0003075)2.01678709
140Steatorrhea (HP:0002570)2.01441146
141Cholecystitis (HP:0001082)1.99723965
142Abnormal gallbladder physiology (HP:0012438)1.99723965
143Abnormality of T cell number (HP:0011839)1.98907450
144Progressive microcephaly (HP:0000253)1.98612237
145Cerebral hypomyelination (HP:0006808)1.97780427
146Sensory axonal neuropathy (HP:0003390)1.95837136
147Thyroiditis (HP:0100646)1.94139451
148Hypophosphatemia (HP:0002148)1.89072261
149Combined immunodeficiency (HP:0005387)1.88969181
150Choreoathetosis (HP:0001266)1.88692265
151Exercise intolerance (HP:0003546)1.87145746
152Abnormal enzyme/coenzyme activity (HP:0012379)1.86861218
153Absence seizures (HP:0002121)1.86505837
154Abnormality of T cells (HP:0002843)1.85743488
155Diplopia (HP:0000651)1.85087790
156Abnormality of binocular vision (HP:0011514)1.85087790
157Myokymia (HP:0002411)1.83960233
158Abnormality of glycolysis (HP:0004366)1.83415091
159Increased serum pyruvate (HP:0003542)1.83415091
160Leukodystrophy (HP:0002415)1.83361151
161Abnormality of complement system (HP:0005339)1.83231987
162Hypercholesterolemia (HP:0003124)1.81592320
163Anxiety (HP:0000739)1.79670898
164Neuronal loss in central nervous system (HP:0002529)1.79080164
165Respiratory failure (HP:0002878)1.77844293
166Conjunctival hamartoma (HP:0100780)1.76670316
167Impaired vibratory sensation (HP:0002495)1.76390286
168Acute hepatic failure (HP:0006554)1.76220905
169Gaze-evoked nystagmus (HP:0000640)1.74675081
170Reduced antithrombin III activity (HP:0001976)1.73113379
171Exertional dyspnea (HP:0002875)1.72537893
172Abnormality of the prostate (HP:0008775)1.72283548
173T lymphocytopenia (HP:0005403)1.71176654
174Abnormality of renal resorption (HP:0011038)1.71067743
175Dialeptic seizures (HP:0011146)1.70436754
176IgG deficiency (HP:0004315)1.69789708
177Pancytopenia (HP:0001876)1.69740523
178Posterior subcapsular cataract (HP:0007787)1.67144535
179Abnormality of the basal ganglia (HP:0002134)1.65537183
180Action tremor (HP:0002345)1.65212628
181Generalized tonic-clonic seizures (HP:0002069)1.64377879
182Tongue fasciculations (HP:0001308)1.63266161
183Hypokinesia (HP:0002375)1.63138258
184Cerebral hemorrhage (HP:0001342)1.63008441
185Recurrent viral infections (HP:0004429)1.62337701
186Bundle branch block (HP:0011710)1.61411493

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OXSR15.23891175
2WNK44.94706718
3WNK34.61975882
4MST44.32111621
5EPHA43.82982442
6BCKDK3.59629651
7STK393.22612813
8NTRK32.98452614
9TESK12.79774502
10EIF2AK32.75621067
11MAP2K42.39888113
12NUAK12.19879156
13DAPK22.13439688
14CAMKK22.12938522
15EIF2AK12.08505612
16MAP2K61.98688231
17MAP3K41.98477822
18CCNB11.85440737
19VRK21.82757380
20SGK4941.76557762
21SGK2231.76557762
22SCYL21.67899937
23BUB11.66892124
24KSR21.61425709
25MAP3K91.52390356
26MAP2K71.49673797
27PHKG21.47697414
28PHKG11.47697414
29MST1R1.41914323
30MAP3K131.41819272
31MINK11.36069580
32PAK61.31287266
33ALK1.26585307
34PBK1.24548986
35NME21.24358273
36PINK11.23073647
37PTK2B1.22009192
38RIPK41.21910647
39CASK1.19875191
40MAP3K121.18807094
41CDK81.18551088
42KSR11.17550457
43STK38L1.15262024
44ERBB41.15026315
45TXK1.12437845
46MAP3K71.09894921
47PLK21.06067380
48ARAF1.05967708
49STK381.05748806
50SGK21.04663495
51DAPK11.04363310
52GRK61.03825814
53ABL21.03383252
54PDK31.01933833
55PDK41.01933833
56PAK31.01153149
57PRKCG0.98911277
58NTRK10.98816558
59FGFR40.97844233
60CAMK2B0.97350009
61STK240.94344442
62CAMK2A0.93749964
63SIK20.92064238
64EIF2AK20.91296259
65STK160.90735750
66PLK30.90720712
67PDPK10.90278548
68WNK10.87288906
69SGK30.85789297
70NEK60.82928432
71MAP3K140.81338348
72MAP3K20.79484125
73SGK10.79008284
74TBK10.78545907
75BMPR20.78063877
76CAMK2G0.78004041
77GRK50.77979216
78NEK10.77691447
79PDK10.77199103
80TAF10.76419492
81MAPK120.75858701
82PRKCZ0.73759601
83SYK0.73737839
84CDK50.73323801
85ERBB30.70098354
86INSRR0.69999285
87MAPK110.67881310
88FGFR20.65723409
89FES0.65631150
90TRPM70.65478557
91MAP3K60.65110179
92RAF10.64306376
93IKBKE0.62891833
94MARK10.61798674
95FRK0.61183228
96SIK30.61082825
97TESK20.60596147
98CDK190.60152025
99MUSK0.59991830
100ZAK0.58501432
101SIK10.57069608
102TLK10.57025888
103RPS6KB20.55999807
104CAMKK10.55801415
105PDK20.55011554
106PRKCQ0.54791450
107TNK20.54595403
108FER0.54121913
109FGR0.54002120
110ITK0.53432335
111RET0.53068664
112TEC0.52801866
113BMPR1B0.51681497
114BRSK10.51581278
115JAK10.51345954
116CAMK2D0.50296555
117MET0.49001233
118NME10.48972412
119MAP3K10.47042851
120LATS20.46103405
121PKN10.45231877
122VRK10.44691046
123PRKACG0.44555033
124PRKAA20.44539257
125EPHB10.44020489
126CAMK10.41897374
127GSK3A0.41580327
128MAP2K10.41580275
129PRKCI0.41408419
130IKBKB0.40965358
131TSSK60.40789931
132STK110.40781248
133PRKD30.40776389
134MAP3K110.40499186
135CSNK1G20.40497005
136PRKCA0.39592662
137PNCK0.39259252
138ERN10.39222953
139TRIM280.37372522
140TAOK30.35742245
141PIK3CG0.33722524
142PRKACA0.33689804
143PTK20.33076113
144JAK20.32868803
145MAPKAPK50.32739573
146NTRK20.32728694
147SRPK10.32221098
148TNIK0.31931299
149STK30.31900632
150PRPF4B0.31854340
151JAK30.30639497
152CDK140.29327244
153DAPK30.28117438
154MAPKAPK30.27288484
155PRKCH0.26431278
156ACVR1B0.25489582
157UHMK10.25355722
158CDK180.23772734

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.67643138
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.42817262
3Nitrogen metabolism_Homo sapiens_hsa009103.29554720
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.15936983
5One carbon pool by folate_Homo sapiens_hsa006703.08563301
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.90367124
7Butanoate metabolism_Homo sapiens_hsa006502.87407962
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.86347882
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.82433972
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.67485843
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.65131919
12Arginine biosynthesis_Homo sapiens_hsa002202.55750030
13Propanoate metabolism_Homo sapiens_hsa006402.48902493
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.40103592
15Tryptophan metabolism_Homo sapiens_hsa003802.34352261
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28349743
17Fatty acid degradation_Homo sapiens_hsa000712.24375494
18Peroxisome_Homo sapiens_hsa041462.22064832
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.02078713
20Type I diabetes mellitus_Homo sapiens_hsa049401.89486458
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.89270279
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.87678151
23Graft-versus-host disease_Homo sapiens_hsa053321.84975803
24Pyruvate metabolism_Homo sapiens_hsa006201.80251374
25Protein export_Homo sapiens_hsa030601.80235871
26DNA replication_Homo sapiens_hsa030301.76406634
27Fatty acid metabolism_Homo sapiens_hsa012121.75382914
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.73626879
29Bile secretion_Homo sapiens_hsa049761.72427113
30beta-Alanine metabolism_Homo sapiens_hsa004101.64252903
31Complement and coagulation cascades_Homo sapiens_hsa046101.63703844
32Sulfur metabolism_Homo sapiens_hsa009201.61847230
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61657871
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.58825389
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.58174307
36Histidine metabolism_Homo sapiens_hsa003401.57654890
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54117785
38Allograft rejection_Homo sapiens_hsa053301.54085707
39PPAR signaling pathway_Homo sapiens_hsa033201.51521351
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48156923
41Non-homologous end-joining_Homo sapiens_hsa034501.46824133
42Fatty acid elongation_Homo sapiens_hsa000621.45329815
43Chemical carcinogenesis_Homo sapiens_hsa052041.44623551
44Autoimmune thyroid disease_Homo sapiens_hsa053201.43191285
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40573393
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.40344338
47Primary immunodeficiency_Homo sapiens_hsa053401.33511376
48Mismatch repair_Homo sapiens_hsa034301.31979351
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27101210
50Carbon metabolism_Homo sapiens_hsa012001.26393543
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.26307105
52Phenylalanine metabolism_Homo sapiens_hsa003601.22798261
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22172833
54Vitamin digestion and absorption_Homo sapiens_hsa049771.21930305
55Intestinal immune network for IgA production_Homo sapiens_hsa046721.18120529
56Steroid biosynthesis_Homo sapiens_hsa001001.17008371
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16683781
58Retinol metabolism_Homo sapiens_hsa008301.15454155
59Starch and sucrose metabolism_Homo sapiens_hsa005001.13690859
60Nucleotide excision repair_Homo sapiens_hsa034201.12801009
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12262019
62Cysteine and methionine metabolism_Homo sapiens_hsa002701.12164073
63Pancreatic secretion_Homo sapiens_hsa049721.06529106
64Biosynthesis of amino acids_Homo sapiens_hsa012301.05134681
65Arginine and proline metabolism_Homo sapiens_hsa003301.04599644
66Rheumatoid arthritis_Homo sapiens_hsa053231.04537474
67Drug metabolism - other enzymes_Homo sapiens_hsa009831.03340124
68Homologous recombination_Homo sapiens_hsa034401.02070066
69Selenocompound metabolism_Homo sapiens_hsa004501.01279501
70Tyrosine metabolism_Homo sapiens_hsa003500.99268677
71Glutathione metabolism_Homo sapiens_hsa004800.98731865
72Antigen processing and presentation_Homo sapiens_hsa046120.93593632
73Collecting duct acid secretion_Homo sapiens_hsa049660.92514109
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91326761
75Asthma_Homo sapiens_hsa053100.88323054
76Folate biosynthesis_Homo sapiens_hsa007900.86146912
77Oocyte meiosis_Homo sapiens_hsa041140.85427687
78Purine metabolism_Homo sapiens_hsa002300.83517386
79Pyrimidine metabolism_Homo sapiens_hsa002400.81465452
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79161832
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76507335
82Glycerolipid metabolism_Homo sapiens_hsa005610.76222673
83Staphylococcus aureus infection_Homo sapiens_hsa051500.73532465
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73484962
85RNA polymerase_Homo sapiens_hsa030200.72804728
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72756710
87Lysine degradation_Homo sapiens_hsa003100.71799777
88Olfactory transduction_Homo sapiens_hsa047400.70235350
89RNA degradation_Homo sapiens_hsa030180.68769200
90Caffeine metabolism_Homo sapiens_hsa002320.68387998
91ABC transporters_Homo sapiens_hsa020100.66331230
92Nicotine addiction_Homo sapiens_hsa050330.65036552
93Circadian rhythm_Homo sapiens_hsa047100.63812559
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61170449
95Huntingtons disease_Homo sapiens_hsa050160.59013074
96Oxidative phosphorylation_Homo sapiens_hsa001900.55998455
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51979817
98Synaptic vesicle cycle_Homo sapiens_hsa047210.51900809
99Phototransduction_Homo sapiens_hsa047440.50363151
100Metabolic pathways_Homo sapiens_hsa011000.49280832
101Base excision repair_Homo sapiens_hsa034100.48601935
102Fat digestion and absorption_Homo sapiens_hsa049750.47897779
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47832054
104Dopaminergic synapse_Homo sapiens_hsa047280.45948468
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.45491017
106Vitamin B6 metabolism_Homo sapiens_hsa007500.44804161
107Sulfur relay system_Homo sapiens_hsa041220.44524141
108Calcium signaling pathway_Homo sapiens_hsa040200.44331087
109Vibrio cholerae infection_Homo sapiens_hsa051100.44029855
110GABAergic synapse_Homo sapiens_hsa047270.43431591
111Oxytocin signaling pathway_Homo sapiens_hsa049210.42577181
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42383854
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38979120
114RNA transport_Homo sapiens_hsa030130.38585098
115Pentose phosphate pathway_Homo sapiens_hsa000300.36180797
116Gastric acid secretion_Homo sapiens_hsa049710.35072582
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33891538
118Glutamatergic synapse_Homo sapiens_hsa047240.33698707
119Ether lipid metabolism_Homo sapiens_hsa005650.33136920
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31700085
121Thyroid hormone synthesis_Homo sapiens_hsa049180.27945535
122Alzheimers disease_Homo sapiens_hsa050100.26921670
123Epstein-Barr virus infection_Homo sapiens_hsa051690.25845818
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.25781933
125Mineral absorption_Homo sapiens_hsa049780.25170967
126Salivary secretion_Homo sapiens_hsa049700.24714512
127Parkinsons disease_Homo sapiens_hsa050120.24029602
128Long-term potentiation_Homo sapiens_hsa047200.23810247
129Fructose and mannose metabolism_Homo sapiens_hsa000510.23111379
130Amphetamine addiction_Homo sapiens_hsa050310.22218122
131Circadian entrainment_Homo sapiens_hsa047130.22207346
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.17516899
133Glucagon signaling pathway_Homo sapiens_hsa049220.15437204
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14736829
135Prion diseases_Homo sapiens_hsa050200.14634407
136Cardiac muscle contraction_Homo sapiens_hsa042600.13891850
137Fatty acid biosynthesis_Homo sapiens_hsa000610.12794115
138Protein digestion and absorption_Homo sapiens_hsa049740.12296386
139Morphine addiction_Homo sapiens_hsa050320.11605052
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.09411389
141Insulin secretion_Homo sapiens_hsa049110.09134191
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.07869607
143Renin secretion_Homo sapiens_hsa049240.06718020
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.06291887
145alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.05247389
146Aldosterone synthesis and secretion_Homo sapiens_hsa049250.04140943

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