PTEN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of glucokinase activity (GO:0033131)4.74601779
2regulation of hexokinase activity (GO:1903299)4.74601779
3negative regulation of protein oligomerization (GO:0032460)4.45036461
4water-soluble vitamin biosynthetic process (GO:0042364)4.38499549
5lactate metabolic process (GO:0006089)4.30543280
6regulation of type B pancreatic cell apoptotic process (GO:2000674)4.26948449
7positive regulation of protein autophosphorylation (GO:0031954)3.69234170
8endocrine pancreas development (GO:0031018)3.68509403
9kidney morphogenesis (GO:0060993)3.59925666
10positive regulation of fatty acid beta-oxidation (GO:0032000)3.56878988
11nitric oxide mediated signal transduction (GO:0007263)3.42523343
12protein K11-linked deubiquitination (GO:0035871)3.42445348
13insulin secretion (GO:0030073)3.41773818
14protein prenylation (GO:0018342)3.40557884
15prenylation (GO:0097354)3.40557884
16signal peptide processing (GO:0006465)3.31347525
17keratinocyte development (GO:0003334)3.30326860
18insulin-like growth factor receptor signaling pathway (GO:0048009)3.29710823
19fucose catabolic process (GO:0019317)3.26028254
20L-fucose metabolic process (GO:0042354)3.26028254
21L-fucose catabolic process (GO:0042355)3.26028254
22urea metabolic process (GO:0019627)3.24708316
23urea cycle (GO:0000050)3.24708316
24negative regulation of acute inflammatory response (GO:0002674)3.24012664
25regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.23641026
26positive regulation of cardiac muscle hypertrophy (GO:0010613)3.22327172
27positive regulation of muscle hypertrophy (GO:0014742)3.22327172
28platelet dense granule organization (GO:0060155)3.22324207
29alpha-linolenic acid metabolic process (GO:0036109)3.20453385
30dicarboxylic acid biosynthetic process (GO:0043650)3.20406226
31positive regulation of insulin secretion (GO:0032024)3.16387589
32regulation of fatty acid beta-oxidation (GO:0031998)3.13637919
33proline transport (GO:0015824)3.08977626
34complement activation, alternative pathway (GO:0006957)3.08118288
35tyrosine metabolic process (GO:0006570)3.06414760
36negative regulation of cytosolic calcium ion concentration (GO:0051481)3.04792480
37positive regulation of peptide hormone secretion (GO:0090277)3.04663969
38cytochrome complex assembly (GO:0017004)3.03771703
39regulation of protein glycosylation (GO:0060049)3.03012230
40cytoplasmic mRNA processing body assembly (GO:0033962)3.02779996
41DNA deamination (GO:0045006)3.02211942
42locomotory exploration behavior (GO:0035641)3.02024213
43positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.00814630
44adaptation of signaling pathway (GO:0023058)2.99428011
45magnesium ion transport (GO:0015693)2.98879577
46respiratory chain complex IV assembly (GO:0008535)2.98442142
47phospholipid homeostasis (GO:0055091)2.98306744
48detection of calcium ion (GO:0005513)2.97288282
49dopamine transport (GO:0015872)2.95199302
50xenobiotic catabolic process (GO:0042178)2.93629596
51growth hormone receptor signaling pathway (GO:0060396)2.91252198
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.91173042
53positive regulation of lipid catabolic process (GO:0050996)2.90941196
54positive regulation of peptide secretion (GO:0002793)2.90377794
55response to pheromone (GO:0019236)2.88631174
56regulation of protein autophosphorylation (GO:0031952)2.88178253
57positive regulation of fatty acid oxidation (GO:0046321)2.86633080
58neural tube formation (GO:0001841)2.85376652
59neutral lipid catabolic process (GO:0046461)2.82875322
60acylglycerol catabolic process (GO:0046464)2.82875322
61positive regulation of respiratory burst (GO:0060267)2.81358228
62protein localization to endosome (GO:0036010)2.81041508
63regulation of protein activation cascade (GO:2000257)2.80403683
64triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.80008193
65positive regulation of glycoprotein biosynthetic process (GO:0010560)2.78891556
66regulation of ARF protein signal transduction (GO:0032012)2.76908267
67triglyceride catabolic process (GO:0019433)2.76158066
68cell wall macromolecule catabolic process (GO:0016998)2.75826170
69negative regulation of protein autophosphorylation (GO:0031953)2.75570944
70layer formation in cerebral cortex (GO:0021819)2.74205215
71retrograde transport, vesicle recycling within Golgi (GO:0000301)2.71845898
72alanine transport (GO:0032328)2.70989931
73protein localization to cilium (GO:0061512)2.70736586
74protein localization to Golgi apparatus (GO:0034067)2.70612853
75nitrogen cycle metabolic process (GO:0071941)2.69889382
76regulation of complement activation (GO:0030449)2.68859252
77tryptophan metabolic process (GO:0006568)2.68752262
78negative regulation of execution phase of apoptosis (GO:1900118)2.64867112
79cell wall macromolecule metabolic process (GO:0044036)2.63856032
80protein carboxylation (GO:0018214)2.63568185
81peptidyl-glutamic acid carboxylation (GO:0017187)2.63568185
82protein targeting to Golgi (GO:0000042)2.62050296
83synaptic vesicle maturation (GO:0016188)2.61988387
84epithelial cell fate commitment (GO:0072148)2.61970695
85negative regulation of cAMP-mediated signaling (GO:0043951)2.61275437
86glutamate secretion (GO:0014047)2.59501356
87axoneme assembly (GO:0035082)2.58777460
88negative regulation of fibrinolysis (GO:0051918)2.57531028
89histamine secretion (GO:0001821)2.57260027
90regulation of short-term neuronal synaptic plasticity (GO:0048172)2.56538482
91negative regulation of sodium ion transport (GO:0010766)2.55481220
92low-density lipoprotein particle clearance (GO:0034383)2.54899230
93* inositol phosphate catabolic process (GO:0071545)2.53136921
94activation of protein kinase A activity (GO:0034199)2.52236637
95positive regulation of glycolytic process (GO:0045821)2.51698576
96positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.51379976
97indolalkylamine metabolic process (GO:0006586)2.49867691
98establishment of protein localization to Golgi (GO:0072600)2.49705452
99cellular ketone body metabolic process (GO:0046950)2.48578407
100negative regulation of cell killing (GO:0031342)2.48185575
101negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.48185575
102nucleobase catabolic process (GO:0046113)2.47708168
103negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.47561124
104regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.46279309
105negative regulation of gluconeogenesis (GO:0045721)2.45997577
106positive regulation of actin filament depolymerization (GO:0030836)2.45008979
107positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.43945260
108early endosome to late endosome transport (GO:0045022)2.43601006
109cellular response to growth hormone stimulus (GO:0071378)2.43145620
110clathrin coat assembly (GO:0048268)2.41791794
111peptidyl-threonine phosphorylation (GO:0018107)2.41770115
112regulation of triglyceride catabolic process (GO:0010896)2.40625953
113fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.40045176
114detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.39813858
115glucocorticoid receptor signaling pathway (GO:0042921)2.38863784
116cyclic nucleotide catabolic process (GO:0009214)2.38621054
117positive regulation of hormone secretion (GO:0046887)2.38423099
118peptidyl-threonine modification (GO:0018210)2.38406797
119mitotic sister chromatid cohesion (GO:0007064)2.37904429
120germ cell migration (GO:0008354)2.37196327
121positive regulation of histone deacetylation (GO:0031065)2.37172459
122regulation of protein polyubiquitination (GO:1902914)2.37012734
123negative regulation of protein activation cascade (GO:2000258)2.36254158
124* polyol catabolic process (GO:0046174)2.36241729
125regulation of glycolytic process (GO:0006110)2.35375362
126RNA destabilization (GO:0050779)2.35101522
127high-density lipoprotein particle remodeling (GO:0034375)2.35072292
128negative regulation of complement activation (GO:0045916)2.34958106
129indole-containing compound catabolic process (GO:0042436)2.34646918
130indolalkylamine catabolic process (GO:0046218)2.34646918
131tryptophan catabolic process (GO:0006569)2.34646918
132epoxygenase P450 pathway (GO:0019373)2.34347896
133reverse cholesterol transport (GO:0043691)2.33845290
134piRNA metabolic process (GO:0034587)2.33582754
135pancreas development (GO:0031016)2.33268698
136ovulation from ovarian follicle (GO:0001542)2.33212863
137positive regulation of cellular carbohydrate metabolic process (GO:0010676)2.33212760
138bile acid biosynthetic process (GO:0006699)2.32737366
139DNA double-strand break processing (GO:0000729)2.32638160
140fatty acid transmembrane transport (GO:1902001)2.32048711
141L-phenylalanine catabolic process (GO:0006559)2.31924681
142erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.31924681
143acylglycerol homeostasis (GO:0055090)2.31602602
144triglyceride homeostasis (GO:0070328)2.31602602
145regulation of neurotransmitter uptake (GO:0051580)2.29598999
146positive regulation of meiosis (GO:0045836)2.29513779
147regulation of insulin secretion (GO:0050796)2.29347654
148positive regulation of nitric-oxide synthase activity (GO:0051000)2.29166103
149regulation of energy homeostasis (GO:2000505)2.29060259
150negative regulation of hormone biosynthetic process (GO:0032353)2.29025981
151homocysteine metabolic process (GO:0050667)2.27640834
152regulation of fibrinolysis (GO:0051917)2.27588914
153reflex (GO:0060004)2.27564621
154glutamate metabolic process (GO:0006536)2.27561731
155regulation of synaptic vesicle exocytosis (GO:2000300)2.26327439
156regulation of clathrin-mediated endocytosis (GO:2000369)2.25921099
157negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.25904737
158regulation of memory T cell differentiation (GO:0043380)2.25640914
159Golgi to endosome transport (GO:0006895)2.25488673
160lipoprotein transport (GO:0042953)2.25140374
161positive regulation of carbohydrate metabolic process (GO:0045913)2.25079665
162aromatic amino acid family catabolic process (GO:0009074)2.24635138
163zinc ion transport (GO:0006829)2.24325643
164valine metabolic process (GO:0006573)2.24224488
165establishment of nucleus localization (GO:0040023)2.24213085
166regulation of Rac protein signal transduction (GO:0035020)2.24093963
167intra-Golgi vesicle-mediated transport (GO:0006891)2.23598723
168photoreceptor cell maintenance (GO:0045494)2.23530111
169thyroid hormone metabolic process (GO:0042403)2.23268623
170regulation of cAMP-dependent protein kinase activity (GO:2000479)2.23196464
171dendrite morphogenesis (GO:0048813)2.22793436
172regulation of lipid catabolic process (GO:0050994)2.22703009
173phospholipid efflux (GO:0033700)2.22665781
174cellular response to ethanol (GO:0071361)2.22289256
175regulation of cardiac muscle hypertrophy (GO:0010611)2.22133608
176preassembly of GPI anchor in ER membrane (GO:0016254)2.21913997
177cerebellar Purkinje cell differentiation (GO:0021702)2.21795130
178microglial cell activation (GO:0001774)2.21469538
179regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.20980141
180regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.19409702
181inositol phosphate-mediated signaling (GO:0048016)2.19267311
182positive regulation of glycogen biosynthetic process (GO:0045725)2.19020623
183catecholamine transport (GO:0051937)2.18312764
184detection of light stimulus involved in sensory perception (GO:0050962)2.17969968
185kynurenine metabolic process (GO:0070189)2.17737124
186ketone body metabolic process (GO:1902224)2.16716506
187plasma lipoprotein particle clearance (GO:0034381)2.16394313
188synaptic vesicle docking involved in exocytosis (GO:0016081)2.15681023
189regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.15510985
190regulation of sequestering of triglyceride (GO:0010889)2.15179486
191G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.14309330
192mitochondrion distribution (GO:0048311)2.13944674

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.19841588
2ZFP57_27257070_Chip-Seq_ESCs_Mouse2.77735182
3ZNF274_21170338_ChIP-Seq_K562_Hela2.52542018
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.51343251
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.44825351
6* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.38880562
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.32302375
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.31394474
9IGF1R_20145208_ChIP-Seq_DFB_Human2.26143068
10* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.24570595
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.23456097
12* BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.11822752
13FUS_26573619_Chip-Seq_HEK293_Human2.10463661
14VDR_22108803_ChIP-Seq_LS180_Human2.07155126
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.06445078
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.06097137
17GBX2_23144817_ChIP-Seq_PC3_Human2.01418510
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.92129669
19EWS_26573619_Chip-Seq_HEK293_Human1.90556957
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.85672720
21ER_23166858_ChIP-Seq_MCF-7_Human1.85162854
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83616751
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79529768
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76827959
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.76665701
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75849146
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.74010405
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69801281
29TAF15_26573619_Chip-Seq_HEK293_Human1.69672653
30EZH2_27294783_Chip-Seq_NPCs_Mouse1.65442322
31TP53_16413492_ChIP-PET_HCT116_Human1.64073832
32* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63226136
33ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.63017371
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60370080
35PPARA_22158963_ChIP-Seq_LIVER_Mouse1.59664300
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59176332
37NANOG_18555785_Chip-Seq_ESCs_Mouse1.57844009
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56728009
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.56679320
40CLOCK_20551151_ChIP-Seq_293T_Human1.55331643
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.54778100
42CBP_20019798_ChIP-Seq_JUKART_Human1.53954592
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53954592
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.52229419
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.50229838
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.49916416
47EZH2_22144423_ChIP-Seq_EOC_Human1.49726565
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.48738736
49SMAD4_21799915_ChIP-Seq_A2780_Human1.48471207
50AR_21572438_ChIP-Seq_LNCaP_Human1.48056974
51AHR_22903824_ChIP-Seq_MCF-7_Human1.47826439
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.47340135
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.46101597
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.44534414
55EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.44157855
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.42916518
57STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.41672525
58P53_22387025_ChIP-Seq_ESCs_Mouse1.41634195
59ESR1_20079471_ChIP-ChIP_T-47D_Human1.40060155
60CDX2_22108803_ChIP-Seq_LS180_Human1.39048235
61BCAT_22108803_ChIP-Seq_LS180_Human1.38119402
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37951198
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37951198
64IRF8_22096565_ChIP-ChIP_GC-B_Human1.37788135
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37118327
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.37061734
67TCF4_18268006_ChIP-ChIP_LS174T_Human1.34715390
68CRX_20693478_ChIP-Seq_RETINA_Mouse1.34369878
69P300_19829295_ChIP-Seq_ESCs_Human1.33729059
70CMYC_18555785_Chip-Seq_ESCs_Mouse1.32807993
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32596374
72FOXA2_19822575_ChIP-Seq_HepG2_Human1.32431116
73* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31331957
74NANOG_19829295_ChIP-Seq_ESCs_Human1.29661837
75SOX2_19829295_ChIP-Seq_ESCs_Human1.29661837
76RUNX_20019798_ChIP-Seq_JUKART_Human1.29221374
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.29079372
78FLI1_21867929_ChIP-Seq_TH2_Mouse1.28097996
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27326910
80RXR_22108803_ChIP-Seq_LS180_Human1.26571755
81SUZ12_18555785_Chip-Seq_ESCs_Mouse1.25985986
82FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.25366615
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24594120
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.24449498
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.24154578
86* SOX2_21211035_ChIP-Seq_LN229_Gbm1.24026396
87STAT3_23295773_ChIP-Seq_U87_Human1.23771106
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22989173
89CTNNB1_20460455_ChIP-Seq_HCT116_Human1.21919511
90OCT4_21477851_ChIP-Seq_ESCs_Mouse1.21056855
91AR_25329375_ChIP-Seq_VCAP_Human1.19391154
92P300_18555785_Chip-Seq_ESCs_Mouse1.19382451
93SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.19277123
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18619047
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18248911
96NOTCH1_21737748_ChIP-Seq_TLL_Human1.17061969
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16862063
98* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16773015
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14396765
100RUNX2_22187159_ChIP-Seq_PCA_Human1.14350999
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14285855
102PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14110858
103GATA1_22025678_ChIP-Seq_K562_Human1.11512917
104TP53_18474530_ChIP-ChIP_U2OS_Human1.10918031
105FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10731877
106PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10623895
107IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10365893
108FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10332078
109FOXA1_25329375_ChIP-Seq_VCAP_Human1.10332078
110TP53_22573176_ChIP-Seq_HFKS_Human1.09996346
111SOX2_18555785_Chip-Seq_ESCs_Mouse1.09861185
112CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09848663
113RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09540523
114PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09509968
115* FOXO3_23340844_ChIP-Seq_DLD1_Human1.09318912
116WT1_19549856_ChIP-ChIP_CCG9911_Human1.09303937
117GATA2_21666600_ChIP-Seq_HMVEC_Human1.08676631
118OCT4_18555785_Chip-Seq_ESCs_Mouse1.08513484
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07800038
120TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06311575
121SMAD4_21741376_ChIP-Seq_EPCs_Human1.06160732
122* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06065898
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06019745
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06011644
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06011644
126SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05529013
127TCF4_23295773_ChIP-Seq_U87_Human1.05503184
128* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04065204
129FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03983764
130TAL1_26923725_Chip-Seq_HPCs_Mouse1.03904985
131GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03547655
132VDR_24787735_ChIP-Seq_THP-1_Human1.03255606
133NMYC_18555785_Chip-Seq_ESCs_Mouse1.03008305
134FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01847877
135NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01707706
136CJUN_26792858_Chip-Seq_BT549_Human1.01086087
137* RARB_27405468_Chip-Seq_BRAIN_Mouse1.00717336
138DROSHA_22980978_ChIP-Seq_HELA_Human1.00069000
139VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99870847
140AR_19668381_ChIP-Seq_PC3_Human0.98685958
141* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98447837
142* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97458006
143FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95151811
144* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94952592
145PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94540983
146* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94276184
147CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93478887
148TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91990696
149YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91781000
150SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91355036
151TCF4_22108803_ChIP-Seq_LS180_Human0.90933188
152* BRD4_25478319_ChIP-Seq_HGPS_Human0.90429286
153SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90417656
154SMAD3_21741376_ChIP-Seq_EPCs_Human0.90344918
155* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89897187
156TRIM28_21343339_ChIP-Seq_HEK293_Human0.89277401
157AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88330843
158* TP63_23658742_ChIP-Seq_EP156T_Human0.88094112
159TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88007164
160* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87889162
161* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86904234
162IRF8_27001747_Chip-Seq_BMDM_Mouse0.86824890

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.91269649
2MP0003195_calcinosis3.84283549
3MP0005360_urolithiasis3.80288033
4MP0008438_abnormal_cutaneous_collagen3.56802147
5MP0005365_abnormal_bile_salt3.19852954
6MP0000569_abnormal_digit_pigmentation3.19727675
7MP0003300_gastrointestinal_ulcer3.14271296
8MP0008877_abnormal_DNA_methylation3.14174142
9MP0009780_abnormal_chondrocyte_physiolo3.12485078
10MP0003705_abnormal_hypodermis_morpholog3.05402974
11MP0005085_abnormal_gallbladder_physiolo3.04948065
12MP0005379_endocrine/exocrine_gland_phen2.87753625
13MP0003252_abnormal_bile_duct2.83290790
14MP0002009_preneoplasia2.62748731
15MP0002163_abnormal_gland_morphology2.59536287
16MP0010329_abnormal_lipoprotein_level2.58714470
17MP0005275_abnormal_skin_tensile2.43498955
18MP0002102_abnormal_ear_morphology2.40254210
19MP0004859_abnormal_synaptic_plasticity2.36646168
20MP0004130_abnormal_muscle_cell2.33061366
21MP0005075_abnormal_melanosome_morpholog2.22185453
22MP0000372_irregular_coat_pigmentation2.21920477
23MP0006072_abnormal_retinal_apoptosis2.18085718
24MP0005645_abnormal_hypothalamus_physiol2.10925038
25MP0003303_peritoneal_inflammation2.10473362
26* MP0002166_altered_tumor_susceptibility2.07802078
27MP0005174_abnormal_tail_pigmentation2.06645074
28MP0002877_abnormal_melanocyte_morpholog2.04580800
29MP0008875_abnormal_xenobiotic_pharmacok1.98072420
30MP0005076_abnormal_cell_differentiation1.96426613
31MP0003122_maternal_imprinting1.95777804
32MP0003045_fibrosis1.92740757
33MP0003121_genomic_imprinting1.90671576
34MP0000015_abnormal_ear_pigmentation1.87954463
35MP0000013_abnormal_adipose_tissue1.87907266
36MP0005646_abnormal_pituitary_gland1.87599091
37* MP0002693_abnormal_pancreas_physiology1.85958356
38MP0003724_increased_susceptibility_to1.84481997
39MP0005551_abnormal_eye_electrophysiolog1.75379760
40MP0002837_dystrophic_cardiac_calcinosis1.73444320
41* MP0001944_abnormal_pancreas_morphology1.71109718
42MP0005253_abnormal_eye_physiology1.70023623
43MP0009046_muscle_twitch1.69921014
44MP0003172_abnormal_lysosome_physiology1.67286841
45MP0001986_abnormal_taste_sensitivity1.66526303
46MP0009697_abnormal_copulation1.62325511
47MP0003868_abnormal_feces_composition1.62303008
48MP0003191_abnormal_cellular_cholesterol1.61310536
49MP0003283_abnormal_digestive_organ1.58974830
50MP0001177_atelectasis1.53533482
51MP0005666_abnormal_adipose_tissue1.52500249
52MP0002876_abnormal_thyroid_physiology1.52254957
53MP0010386_abnormal_urinary_bladder1.50146142
54MP0004185_abnormal_adipocyte_glucose1.47677582
55MP0005084_abnormal_gallbladder_morpholo1.43716572
56MP0002638_abnormal_pupillary_reflex1.40567816
57MP0008775_abnormal_heart_ventricle1.35508676
58MP0003635_abnormal_synaptic_transmissio1.34365357
59* MP0000609_abnormal_liver_physiology1.34007079
60MP0001968_abnormal_touch/_nociception1.31327108
61MP0000003_abnormal_adipose_tissue1.30876922
62* MP0002006_tumorigenesis1.30330871
63MP0005375_adipose_tissue_phenotype1.30212921
64MP0005187_abnormal_penis_morphology1.27771375
65MP0006054_spinal_hemorrhage1.27572641
66MP0005670_abnormal_white_adipose1.26770095
67MP0003011_delayed_dark_adaptation1.26721196
68MP0004885_abnormal_endolymph1.26497078
69MP0008872_abnormal_physiological_respon1.25661190
70MP0002909_abnormal_adrenal_gland1.24984194
71MP0002254_reproductive_system_inflammat1.24679576
72MP0005334_abnormal_fat_pad1.22942431
73MP0008961_abnormal_basal_metabolism1.22659542
74* MP0002118_abnormal_lipid_homeostasis1.21359031
75MP0002138_abnormal_hepatobiliary_system1.21292440
76MP0001501_abnormal_sleep_pattern1.20771627
77MP0003646_muscle_fatigue1.20417561
78MP0003279_aneurysm1.20090545
79MP0003091_abnormal_cell_migration1.19392441
80MP0002063_abnormal_learning/memory/cond1.14251207
81* MP0005220_abnormal_exocrine_pancreas1.10941339
82MP0001879_abnormal_lymphatic_vessel1.10757901
83MP0004215_abnormal_myocardial_fiber1.10442555
84MP0009115_abnormal_fat_cell1.09232993
85MP0001666_abnormal_nutrient_absorption1.07840437
86MP0005535_abnormal_body_temperature1.07143720
87* MP0010352_gastrointestinal_tract_polyps1.07132110
88MP0008874_decreased_physiological_sensi1.06493615
89MP0004883_abnormal_blood_vessel1.05476478
90MP0000230_abnormal_systemic_arterial1.03157697
91MP0002168_other_aberrant_phenotype1.00751300
92MP0004808_abnormal_hematopoietic_stem0.99349896
93MP0004270_analgesia0.99126323
94MP0002272_abnormal_nervous_system0.97929756
95MP0001835_abnormal_antigen_presentation0.96135564
96MP0004381_abnormal_hair_follicle0.95113458
97* MP0000427_abnormal_hair_cycle0.94812675
98MP0001764_abnormal_homeostasis0.94107647
99* MP0002078_abnormal_glucose_homeostasis0.94005989
100MP0002971_abnormal_brown_adipose0.90963838
101MP0005503_abnormal_tendon_morphology0.89845349
102MP0001765_abnormal_ion_homeostasis0.89380722
103MP0005464_abnormal_platelet_physiology0.89148701
104MP0004043_abnormal_pH_regulation0.89120172
105MP0003183_abnormal_peptide_metabolism0.88964425
106MP0002095_abnormal_skin_pigmentation0.88188263
107* MP0001756_abnormal_urination0.87752245
108MP0002133_abnormal_respiratory_system0.87191358
109MP0005388_respiratory_system_phenotype0.87191358
110MP0002277_abnormal_respiratory_mucosa0.87146950
111MP0000639_abnormal_adrenal_gland0.86777529
112* MP0010307_abnormal_tumor_latency0.85891105
113MP0000631_abnormal_neuroendocrine_gland0.85609433
114* MP0003633_abnormal_nervous_system0.85397655
115MP0005408_hypopigmentation0.83620135
116* MP0002060_abnormal_skin_morphology0.83272821
117MP0004142_abnormal_muscle_tone0.81427066
118MP0005584_abnormal_enzyme/coenzyme_acti0.80596436
119MP0005636_abnormal_mineral_homeostasis0.79687285
120MP0005448_abnormal_energy_balance0.78228583
121MP0001919_abnormal_reproductive_system0.77240576
122MP0000604_amyloidosis0.76903466
123* MP0003953_abnormal_hormone_level0.76116176
124MP0002896_abnormal_bone_mineralization0.75878331
125* MP0002928_abnormal_bile_duct0.75148058
126MP0002735_abnormal_chemical_nociception0.74761392
127MP0001486_abnormal_startle_reflex0.74578841
128MP0003690_abnormal_glial_cell0.74218259
129MP0002938_white_spotting0.74206391
130MP0002557_abnormal_social/conspecific_i0.72482887
131MP0004134_abnormal_chest_morphology0.72348562
132MP0005167_abnormal_blood-brain_barrier0.71855697
133MP0003787_abnormal_imprinting0.71232777
134MP0000685_abnormal_immune_system0.71219918
135MP0005310_abnormal_salivary_gland0.71151941
136MP0005171_absent_coat_pigmentation0.71069265
137* MP0009745_abnormal_behavioral_response0.71023495
138MP0004085_abnormal_heartbeat0.70926061
139MP0006036_abnormal_mitochondrial_physio0.70431170
140* MP0004924_abnormal_behavior0.69717484
141* MP0005386_behavior/neurological_phenoty0.69717484
142MP0003828_pulmonary_edema0.68517957
143MP0000613_abnormal_salivary_gland0.68298311
144MP0010368_abnormal_lymphatic_system0.68021667
145MP0005332_abnormal_amino_acid0.67795813
146MP0004019_abnormal_vitamin_homeostasis0.67714988
147MP0001440_abnormal_grooming_behavior0.67280489
148MP0002736_abnormal_nociception_after0.67068531
149MP0000371_diluted_coat_color0.66926757
150MP0002734_abnormal_mechanical_nocicepti0.66804384
151* MP0005389_reproductive_system_phenotype0.65969365
152MP0004484_altered_response_of0.65899224
153* MP0004811_abnormal_neuron_physiology0.65812225
154MP0002090_abnormal_vision0.65617950
155MP0005248_abnormal_Harderian_gland0.65240087
156* MP0000598_abnormal_liver_morphology0.65171360
157MP0005164_abnormal_response_to0.64912074
158MP0001915_intracranial_hemorrhage0.63587937
159MP0001324_abnormal_eye_pigmentation0.63129592
160MP0009703_decreased_birth_body0.62963901
161MP0009643_abnormal_urine_homeostasis0.62518590
162MP0002970_abnormal_white_adipose0.61792786
163MP0000249_abnormal_blood_vessel0.59014317
164MP0003566_abnormal_cell_adhesion0.58294787
165MP0001958_emphysema0.57263818
166* MP0010234_abnormal_vibrissa_follicle0.56424260
167MP0009278_abnormal_bone_marrow0.56375316
168MP0002295_abnormal_pulmonary_circulatio0.54777034

Predicted human phenotypes

RankGene SetZ-score
1Ketoacidosis (HP:0001993)4.33182049
2Hypothermia (HP:0002045)4.31102327
3Hypoglycemic seizures (HP:0002173)4.15830990
4Hyperinsulinemic hypoglycemia (HP:0000825)4.00414287
5Hypoglycemic coma (HP:0001325)3.77064943
6Papilledema (HP:0001085)3.71487023
7Deep venous thrombosis (HP:0002625)3.54014511
8Abnormality of endocrine pancreas physiology (HP:0012093)3.44970143
9Abnormality of the pancreatic islet cells (HP:0006476)3.44970143
10Ketosis (HP:0001946)3.26590017
11Complement deficiency (HP:0004431)3.22121791
12Large for gestational age (HP:0001520)3.20284753
13Mitral stenosis (HP:0001718)3.20134140
14Subacute progressive viral hepatitis (HP:0006572)3.19680164
15Methylmalonic acidemia (HP:0002912)3.18747226
16Pancreatic cysts (HP:0001737)3.12459906
17Epidermoid cyst (HP:0200040)3.10840322
18Hemiparesis (HP:0001269)3.01937122
19Abnormality of the renal cortex (HP:0011035)2.97295122
20Myocardial infarction (HP:0001658)2.93183988
21Pancreatic fibrosis (HP:0100732)2.91750585
22Hypomagnesemia (HP:0002917)2.88327358
23Abnormality of vitamin B metabolism (HP:0004340)2.87794933
24Gaze-evoked nystagmus (HP:0000640)2.85342146
25Renal cortical cysts (HP:0000803)2.77616212
26Abnormal rod and cone electroretinograms (HP:0008323)2.73911585
27Abnormality of the common coagulation pathway (HP:0010990)2.71288142
28Symptomatic seizures (HP:0011145)2.69915441
29Stomatitis (HP:0010280)2.69325019
30Congenital stationary night blindness (HP:0007642)2.59360735
31Xanthomatosis (HP:0000991)2.58050841
32Hypochromic microcytic anemia (HP:0004840)2.54942557
33Absent frontal sinuses (HP:0002688)2.53702115
34True hermaphroditism (HP:0010459)2.53542340
35Arterial tortuosity (HP:0005116)2.53399462
36Medial flaring of the eyebrow (HP:0010747)2.52244894
37Methylmalonic aciduria (HP:0012120)2.51562460
38Attenuation of retinal blood vessels (HP:0007843)2.48246508
39Abnormal drinking behavior (HP:0030082)2.48148617
40Polydipsia (HP:0001959)2.48148617
41Spontaneous hematomas (HP:0007420)2.47673142
42Metaphyseal dysplasia (HP:0100255)2.47487271
43Intrahepatic cholestasis (HP:0001406)2.45446514
44Insidious onset (HP:0003587)2.45243372
45Termporal pattern (HP:0011008)2.45243372
46Vascular tortuosity (HP:0004948)2.44174172
47Pancreatic islet-cell hyperplasia (HP:0004510)2.43037076
48Hypoalphalipoproteinemia (HP:0003233)2.42825898
49Nephronophthisis (HP:0000090)2.40492424
50Aortic aneurysm (HP:0004942)2.39095126
51Mitral valve prolapse (HP:0001634)2.38445673
52Cerebral aneurysm (HP:0004944)2.36209383
53Abnormality of the fingertips (HP:0001211)2.35569077
54Intestinal atresia (HP:0011100)2.34529353
55Hypoplasia of the fovea (HP:0007750)2.33871852
56Aplasia/Hypoplasia of the fovea (HP:0008060)2.33871852
57Congenital sensorineural hearing impairment (HP:0008527)2.32145020
58Drooling (HP:0002307)2.30063753
59Excessive salivation (HP:0003781)2.30063753
60Abnormality of the renal medulla (HP:0100957)2.29073127
61Molar tooth sign on MRI (HP:0002419)2.27923757
62Abnormality of midbrain morphology (HP:0002418)2.27923757
63Tongue fasciculations (HP:0001308)2.27625832
64* Macroorchidism (HP:0000053)2.26239948
65Skin nodule (HP:0200036)2.24150300
66Hyperlipoproteinemia (HP:0010980)2.23068454
67Resting tremor (HP:0002322)2.22787027
68Abnormality of monocarboxylic acid metabolism (HP:0010996)2.21694883
69Generalized hypopigmentation of hair (HP:0011358)2.21626493
70Prominent metopic ridge (HP:0005487)2.19907819
71Abnormality of complement system (HP:0005339)2.19580232
72Albinism (HP:0001022)2.19177227
73Action tremor (HP:0002345)2.18329196
74Hypolipoproteinemia (HP:0010981)2.15638203
75Striae distensae (HP:0001065)2.15329014
76Hypobetalipoproteinemia (HP:0003563)2.14710353
77Widely spaced teeth (HP:0000687)2.14653931
78Abnormality of the metopic suture (HP:0005556)2.13984462
79Abolished electroretinogram (ERG) (HP:0000550)2.13923988
80Abnormal albumin level (HP:0012116)2.13867532
81Hypoalbuminemia (HP:0003073)2.13867532
82Agitation (HP:0000713)2.13244151
83Volvulus (HP:0002580)2.13119270
84Muscle fibrillation (HP:0010546)2.13085103
85Ankyloglossia (HP:0010296)2.12380840
86Fair hair (HP:0002286)2.10755896
87Disproportionate short-trunk short stature (HP:0003521)2.09762947
88Hyperventilation (HP:0002883)2.09316577
89EEG with generalized epileptiform discharges (HP:0011198)2.09232921
90Dilatation of the ascending aorta (HP:0005111)2.08657032
91Abnormality of the vitamin B12 metabolism (HP:0004341)2.08155971
92Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.07973561
93Inappropriate behavior (HP:0000719)2.07688882
94Insulin-resistant diabetes mellitus (HP:0000831)2.07182461
95Progressive inability to walk (HP:0002505)2.05875537
96Papillary thyroid carcinoma (HP:0002895)2.05863999
97Abnormal pancreas size (HP:0012094)2.05682122
98Hepatocellular carcinoma (HP:0001402)2.05046556
99Hypsarrhythmia (HP:0002521)2.04925296
100Aneurysm (HP:0002617)2.04475748
101Epileptiform EEG discharges (HP:0011182)2.04468524
102Cellulitis (HP:0100658)2.03585559
103Viral hepatitis (HP:0006562)2.03522494
104Agammaglobulinemia (HP:0004432)2.02910188
105Absent rod-and cone-mediated responses on ERG (HP:0007688)1.99284679
106Abnormality of the fovea (HP:0000493)1.99016352
107Late onset (HP:0003584)1.98324430
108Hypoproteinemia (HP:0003075)1.98098131
109Increased CSF protein (HP:0002922)1.97365880
110Tubular atrophy (HP:0000092)1.95079637
111Constricted visual fields (HP:0001133)1.91146334
112Abnormality of vitamin metabolism (HP:0100508)1.90322766
113Focal seizures (HP:0007359)1.88509997
114Dysmetric saccades (HP:0000641)1.88054417
115Abnormality of aromatic amino acid family metabolism (HP:0004338)1.87849849
116Overgrowth (HP:0001548)1.87801499
117Chronic hepatic failure (HP:0100626)1.86023852
118* Verrucae (HP:0200043)1.85822401
119* Papilloma (HP:0012740)1.85822401
120Prolonged partial thromboplastin time (HP:0003645)1.83709722
121Downturned corners of mouth (HP:0002714)1.83267272
122Visual hallucinations (HP:0002367)1.83015144
123Joint hemorrhage (HP:0005261)1.82639973
124Coarse hair (HP:0002208)1.82319726
125Impaired social interactions (HP:0000735)1.82264906
126Abnormal social behavior (HP:0012433)1.82264906
127Polyuria (HP:0000103)1.81830823
128Protrusio acetabuli (HP:0003179)1.81201013
129Abnormality of magnesium homeostasis (HP:0004921)1.81042208
130Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80794771
131Osteolytic defects of the phalanges of the hand (HP:0009771)1.80655709
132Osteolytic defects of the hand bones (HP:0009699)1.80655709
133Increased corneal curvature (HP:0100692)1.80426796
134Keratoconus (HP:0000563)1.80426796
135Abnormality of glutamine family amino acid metabolism (HP:0010902)1.80361043
136Recurrent gram-negative bacterial infections (HP:0005420)1.80356607
137Aortic dissection (HP:0002647)1.80260585
138Abnormality of oral frenula (HP:0000190)1.79422184
139Calf muscle hypertrophy (HP:0008981)1.79208718
140Increased mean platelet volume (HP:0011877)1.77776691
141Muscular hypotonia of the trunk (HP:0008936)1.77068687
142Aplasia/Hypoplasia of the macula (HP:0008059)1.76313423
143Oligomenorrhea (HP:0000876)1.75554361
144Increased circulating renin level (HP:0000848)1.75544122
145Type I diabetes mellitus (HP:0100651)1.74947392
146Narrow palate (HP:0000189)1.74404972
147Metabolic alkalosis (HP:0200114)1.73575008
148Cystic liver disease (HP:0006706)1.72465886
149* Furrowed tongue (HP:0000221)1.72342086
150Focal motor seizures (HP:0011153)1.71657872
151Rectal prolapse (HP:0002035)1.71507077
152Acanthocytosis (HP:0001927)1.71472655
153Truncal obesity (HP:0001956)1.71157424
154Congenital, generalized hypertrichosis (HP:0004540)1.70976589
155Congenital primary aphakia (HP:0007707)1.70336829
156Abnormality of the intrinsic pathway (HP:0010989)1.70148024
157Absent speech (HP:0001344)1.69632910
158Atonic seizures (HP:0010819)1.68340812
159Colitis (HP:0002583)1.68335026
160Episodic fever (HP:0001954)1.67486290
161Abnormality of urine glucose concentration (HP:0011016)1.66938897
162Glycosuria (HP:0003076)1.66938897
163Gait imbalance (HP:0002141)1.66737448
164* Thyroiditis (HP:0100646)1.66537089
165Exotropia (HP:0000577)1.65805245
166Osteomyelitis (HP:0002754)1.65585099
167* Hematochezia (HP:0002573)1.65433683
168Heterotopia (HP:0002282)1.65355435
169Febrile seizures (HP:0002373)1.64968401
170Decreased circulating renin level (HP:0003351)1.64597595
171Absence seizures (HP:0002121)1.64400093
172Bony spicule pigmentary retinopathy (HP:0007737)1.64381889
173Aplasia/Hypoplasia affecting the retina (HP:0008061)1.63697110
174Broad ribs (HP:0000885)1.63648058
175Urinary bladder sphincter dysfunction (HP:0002839)1.62842075
176Hyperglycemia (HP:0003074)1.62321864
177Palpebral edema (HP:0100540)1.62289191
178Abnormality of methionine metabolism (HP:0010901)1.62008577
179Abnormal platelet volume (HP:0011876)1.61644616
180Long toe (HP:0010511)1.61605117
181Postural instability (HP:0002172)1.61275778
182Blue irides (HP:0000635)1.61235123
183Poor eye contact (HP:0000817)1.61205752
184Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.61171887
185Impaired vibration sensation in the lower limbs (HP:0002166)1.61132159
186Abnormality of the lower motor neuron (HP:0002366)1.60947182
187Hemorrhage of the eye (HP:0011885)1.60676745
188Spontaneous abortion (HP:0005268)1.59289213
189Hypoplasia of the thymus (HP:0000778)1.57617011
190Peritonitis (HP:0002586)1.57332361
191Gastrointestinal infarctions (HP:0005244)1.56161812
192Pigmentary retinal degeneration (HP:0001146)1.56130682

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B2.88126206
2MST42.76529624
3MAP4K22.74355852
4BMPR1B2.73372575
5CAMK1D2.51683340
6WNK32.40226104
7EIF2AK32.36153767
8MAP3K22.34943353
9TRIM282.33603053
10CAMK1G2.32241926
11MAP3K42.19812024
12PKN22.16307403
13SIK12.11905173
14GRK12.09549039
15PINK12.06835129
16NLK2.03863493
17MAP3K92.00114236
18SGK21.97707637
19LATS11.97245969
20SGK31.94331689
21RIPK41.88065981
22ADRBK21.87655115
23MAP3K101.84999714
24TNIK1.81983686
25SCYL21.81160172
26OXSR11.77516916
27NTRK31.76515419
28MAP2K41.76247669
29TRIB31.64368273
30SIK21.60983285
31RET1.60412105
32STK391.60037438
33KSR21.50504634
34EPHA41.48778393
35RIPK11.46415115
36FES1.43531184
37STK38L1.41550052
38DAPK21.37843475
39JAK11.36968476
40CASK1.35982618
41EEF2K1.35290950
42CSNK1G11.34348467
43GRK61.32163094
44PRKCH1.31324488
45CAMKK11.31090046
46PDGFRA1.29464666
47INSRR1.28823513
48PHKG11.28783969
49PHKG21.28783969
50ERBB31.27071847
51MINK11.26995479
52STK241.26966872
53MARK11.23994618
54PRKCE1.20054565
55BMPR21.16789154
56CDK61.16614031
57KSR11.15973847
58MKNK21.09923394
59IRAK11.08762229
60MAPK131.08355981
61PTK61.06095892
62CSNK1G31.05920634
63AKT31.05807560
64RPS6KB11.04312763
65PLK21.03979388
66PDK11.01951569
67NUAK11.00283509
68YES10.99004259
69* FGFR30.96467046
70CDK90.95819602
71SGK4940.94978469
72SGK2230.94978469
73TEC0.94358802
74TGFBR20.92954551
75PIK3CA0.90444353
76SGK10.89687718
77ADRBK10.88754361
78PDGFRB0.87815169
79STK30.87699393
80MAP2K70.85761784
81LMTK20.84236637
82CSNK1A1L0.83533470
83MAP3K120.83205440
84TXK0.81970904
85JAK20.81864830
86CAMKK20.79961854
87* FRK0.79693825
88MAP2K60.77617876
89MST1R0.76768286
90PRKAA20.75557224
91NEK90.74645755
92PIK3CG0.74291114
93KIT0.73954470
94CSF1R0.73475507
95MAP3K130.73407679
96ALK0.72950085
97DMPK0.72720371
98MAPK120.72480226
99BCR0.71714514
100LATS20.71607599
101WNK40.71511486
102EIF2AK10.70937270
103RPS6KA20.70734729
104PAK30.70704077
105MAP3K70.70485330
106MAP2K10.69844493
107TRPM70.68587375
108FER0.67916898
109MAPK70.67693115
110PRKAA10.67610941
111MAP3K140.66337718
112TNK20.65096157
113IKBKB0.65065023
114TYK20.64640812
115PTK2B0.64346622
116ERN10.62308551
117PRKD30.61318903
118CDK50.61012339
119PASK0.60839049
120PDPK10.59640414
121MUSK0.59096505
122STK380.58804106
123HIPK20.58663769
124ZAK0.57964283
125FGFR40.57736450
126TAOK30.57291264
127HCK0.56057048
128TTN0.55914675
129ITK0.55710770
130NTRK10.55667165
131SYK0.55188534
132TAF10.54404302
133IKBKE0.54299408
134TIE10.53650884
135PRKCG0.53052894
136PAK60.52957623
137GRK50.52778763
138PRKCQ0.52513809
139TGFBR10.52158538
140IRAK40.51913098
141NTRK20.51709230
142MAPK40.45996098
143WNK10.45744031
144ABL10.45326038
145CSNK1G20.45318051
146RPS6KA30.45315815
147MAP3K60.44730739
148EPHA30.44232571
149FLT30.44088734
150CDK120.43931886
151* STK110.43792660
152STK40.43411546
153MELK0.42606388
154TLK10.42209036
155CAMK2D0.42124740
156PRKCI0.40955334
157PRKG10.38811325
158EGFR0.37507490
159CSNK1D0.36300671
160PRKACA0.35674187
161CSNK1A10.34365666
162BRSK20.34322848
163CAMK2A0.33116606
164GSK3A0.32510775
165DYRK1A0.32004572
166EIF2AK20.31552159

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.60036184
2Nitrogen metabolism_Homo sapiens_hsa009103.30125093
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.05613291
4Protein export_Homo sapiens_hsa030602.95586887
5Type I diabetes mellitus_Homo sapiens_hsa049402.18843351
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.05741966
7Phototransduction_Homo sapiens_hsa047442.03823212
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.91425480
9Arginine biosynthesis_Homo sapiens_hsa002201.91411111
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90263384
11Collecting duct acid secretion_Homo sapiens_hsa049661.88969953
12Regulation of autophagy_Homo sapiens_hsa041401.85905452
13Vitamin B6 metabolism_Homo sapiens_hsa007501.72604825
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.67985594
15Sulfur metabolism_Homo sapiens_hsa009201.63276580
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62818417
17Long-term potentiation_Homo sapiens_hsa047201.50341358
18Olfactory transduction_Homo sapiens_hsa047401.50133134
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.47894825
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.46146298
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44267046
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.43393420
23Complement and coagulation cascades_Homo sapiens_hsa046101.43364554
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42285697
25Type II diabetes mellitus_Homo sapiens_hsa049301.42089753
26Ether lipid metabolism_Homo sapiens_hsa005651.40714401
27Renin secretion_Homo sapiens_hsa049241.37177912
28Peroxisome_Homo sapiens_hsa041461.35937930
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31676005
30* Glioma_Homo sapiens_hsa052141.30635647
31PPAR signaling pathway_Homo sapiens_hsa033201.28848135
32Linoleic acid metabolism_Homo sapiens_hsa005911.25686317
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21733631
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20424415
35Caffeine metabolism_Homo sapiens_hsa002321.18559742
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17290624
37Dorso-ventral axis formation_Homo sapiens_hsa043201.17277519
38Bile secretion_Homo sapiens_hsa049761.15980454
39Fatty acid elongation_Homo sapiens_hsa000621.13603200
40B cell receptor signaling pathway_Homo sapiens_hsa046621.12416746
41Staphylococcus aureus infection_Homo sapiens_hsa051501.10129569
42Non-small cell lung cancer_Homo sapiens_hsa052231.09979807
43Circadian entrainment_Homo sapiens_hsa047131.08848135
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08747878
45Estrogen signaling pathway_Homo sapiens_hsa049151.08747315
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07082883
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04833534
48* mTOR signaling pathway_Homo sapiens_hsa041501.04392456
49Dopaminergic synapse_Homo sapiens_hsa047281.04377037
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04255657
51Amphetamine addiction_Homo sapiens_hsa050311.03722762
52Circadian rhythm_Homo sapiens_hsa047101.01817362
53Fatty acid biosynthesis_Homo sapiens_hsa000611.01505808
54Selenocompound metabolism_Homo sapiens_hsa004501.01417917
55Glucagon signaling pathway_Homo sapiens_hsa049221.00187154
56* Insulin resistance_Homo sapiens_hsa049310.99899971
57Morphine addiction_Homo sapiens_hsa050320.98893759
58Butanoate metabolism_Homo sapiens_hsa006500.98509759
59* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97879993
60Salivary secretion_Homo sapiens_hsa049700.97026526
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95889901
62Cholinergic synapse_Homo sapiens_hsa047250.94902672
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92180822
64GABAergic synapse_Homo sapiens_hsa047270.91856803
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90690010
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90610138
67Glutamatergic synapse_Homo sapiens_hsa047240.90282524
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88965487
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88531220
70Insulin signaling pathway_Homo sapiens_hsa049100.87346143
71GnRH signaling pathway_Homo sapiens_hsa049120.86934912
72* Endometrial cancer_Homo sapiens_hsa052130.86931706
73Tryptophan metabolism_Homo sapiens_hsa003800.86694862
74Gastric acid secretion_Homo sapiens_hsa049710.86681713
75Platelet activation_Homo sapiens_hsa046110.85112744
76Serotonergic synapse_Homo sapiens_hsa047260.84944421
77AMPK signaling pathway_Homo sapiens_hsa041520.84739944
78Oxytocin signaling pathway_Homo sapiens_hsa049210.83636401
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.83254419
80Fatty acid degradation_Homo sapiens_hsa000710.83051809
81Non-homologous end-joining_Homo sapiens_hsa034500.82592281
82Insulin secretion_Homo sapiens_hsa049110.81583228
83Pancreatic cancer_Homo sapiens_hsa052120.81111337
84Thyroid hormone synthesis_Homo sapiens_hsa049180.80614959
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80222285
86Chemical carcinogenesis_Homo sapiens_hsa052040.79758712
87Sphingolipid metabolism_Homo sapiens_hsa006000.79648270
88Mineral absorption_Homo sapiens_hsa049780.78549969
89Taste transduction_Homo sapiens_hsa047420.78403000
90Retinol metabolism_Homo sapiens_hsa008300.76776434
91Ovarian steroidogenesis_Homo sapiens_hsa049130.76624416
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76096426
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.75265638
94Lysine degradation_Homo sapiens_hsa003100.73607973
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73281739
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72694116
97Basal transcription factors_Homo sapiens_hsa030220.72478091
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72444710
99cAMP signaling pathway_Homo sapiens_hsa040240.72310645
100Chronic myeloid leukemia_Homo sapiens_hsa052200.72246477
101ErbB signaling pathway_Homo sapiens_hsa040120.71923823
102Glycerolipid metabolism_Homo sapiens_hsa005610.71346117
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70908064
104Nicotine addiction_Homo sapiens_hsa050330.69638052
105Fatty acid metabolism_Homo sapiens_hsa012120.69209966
106Long-term depression_Homo sapiens_hsa047300.69118615
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.68733809
108Folate biosynthesis_Homo sapiens_hsa007900.68371295
109beta-Alanine metabolism_Homo sapiens_hsa004100.68316632
110* Focal adhesion_Homo sapiens_hsa045100.68289253
111Choline metabolism in cancer_Homo sapiens_hsa052310.68029423
112* FoxO signaling pathway_Homo sapiens_hsa040680.66981573
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.65472753
114Synaptic vesicle cycle_Homo sapiens_hsa047210.64947393
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64865100
116Oxidative phosphorylation_Homo sapiens_hsa001900.64462905
117Propanoate metabolism_Homo sapiens_hsa006400.64116057
118Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64009042
119ABC transporters_Homo sapiens_hsa020100.63800658
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62540723
121Proteoglycans in cancer_Homo sapiens_hsa052050.62212051
122Adherens junction_Homo sapiens_hsa045200.62035078
123Osteoclast differentiation_Homo sapiens_hsa043800.61612116
124Rheumatoid arthritis_Homo sapiens_hsa053230.61309838
125Arachidonic acid metabolism_Homo sapiens_hsa005900.61241710
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.60788441
127RNA degradation_Homo sapiens_hsa030180.60745716
128Chemokine signaling pathway_Homo sapiens_hsa040620.60648700
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60397431
130Starch and sucrose metabolism_Homo sapiens_hsa005000.60072152
131Gap junction_Homo sapiens_hsa045400.59843472
132VEGF signaling pathway_Homo sapiens_hsa043700.59718806
133Cocaine addiction_Homo sapiens_hsa050300.56914587
134Prolactin signaling pathway_Homo sapiens_hsa049170.56651048
135Renal cell carcinoma_Homo sapiens_hsa052110.55929887
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55257542
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.54876962
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53971303
139AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53754691
140* Prostate cancer_Homo sapiens_hsa052150.52707211
141Amoebiasis_Homo sapiens_hsa051460.52680988
142Colorectal cancer_Homo sapiens_hsa052100.51452857
143Toxoplasmosis_Homo sapiens_hsa051450.49803171
144Legionellosis_Homo sapiens_hsa051340.49164330
145Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48847206
146Melanogenesis_Homo sapiens_hsa049160.48470584
147Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47803386
148Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47661972
149MAPK signaling pathway_Homo sapiens_hsa040100.46895012
150Pancreatic secretion_Homo sapiens_hsa049720.45646721
151Jak-STAT signaling pathway_Homo sapiens_hsa046300.44340607
152Asthma_Homo sapiens_hsa053100.43349335
153Calcium signaling pathway_Homo sapiens_hsa040200.39137562
154Fanconi anemia pathway_Homo sapiens_hsa034600.38510562
155Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37802485
156Autoimmune thyroid disease_Homo sapiens_hsa053200.37773321
157Glycerophospholipid metabolism_Homo sapiens_hsa005640.37753644
158Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37360378
159Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35453683
160Allograft rejection_Homo sapiens_hsa053300.35298350
161Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32498738

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