PTCRA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)7.90400040
2thrombin receptor signaling pathway (GO:0070493)6.57462231
3regulation of platelet aggregation (GO:0090330)6.07987499
4regulation of platelet activation (GO:0010543)5.48453478
5blood coagulation, intrinsic pathway (GO:0007597)5.43567692
6adenosine receptor signaling pathway (GO:0001973)5.36445001
7leukocyte migration involved in inflammatory response (GO:0002523)5.34530669
8chaperone-mediated protein transport (GO:0072321)5.06282620
9platelet aggregation (GO:0070527)4.96824963
10negative regulation of homotypic cell-cell adhesion (GO:0034111)4.95098688
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.87062274
12positive regulation of mast cell activation (GO:0033005)4.86802194
13neutrophil activation (GO:0042119)4.82961810
14lipoxygenase pathway (GO:0019372)4.81983441
15positive regulation of endothelial cell differentiation (GO:0045603)4.69195929
16transcription elongation from RNA polymerase III promoter (GO:0006385)4.64401619
17termination of RNA polymerase III transcription (GO:0006386)4.64401619
18long-chain fatty acid biosynthetic process (GO:0042759)4.60060211
19negative regulation of platelet activation (GO:0010544)4.51154134
20granulocyte activation (GO:0036230)4.36608228
21central nervous system myelination (GO:0022010)4.28757505
22axon ensheathment in central nervous system (GO:0032291)4.28757505
23negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.24391459
24angiogenesis involved in wound healing (GO:0060055)4.22176707
25negative regulation of norepinephrine secretion (GO:0010700)4.16348476
26ribosomal small subunit assembly (GO:0000028)4.16160832
27positive regulation of macrophage differentiation (GO:0045651)4.13281374
28regulation of integrin-mediated signaling pathway (GO:2001044)4.09693387
29ribosomal small subunit biogenesis (GO:0042274)4.09102859
30G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.05937879
31negative regulation of heart rate (GO:0010459)4.04288070
32polyamine biosynthetic process (GO:0006596)4.00248758
33proteasome assembly (GO:0043248)3.97042439
34ribosomal large subunit biogenesis (GO:0042273)3.94846232
35low-density lipoprotein particle remodeling (GO:0034374)3.92670165
36purinergic nucleotide receptor signaling pathway (GO:0035590)3.85116533
37positive regulation of protein homodimerization activity (GO:0090073)3.81530062
38positive regulation of cAMP-mediated signaling (GO:0043950)3.78054983
39regulation of integrin activation (GO:0033623)3.76160074
40platelet degranulation (GO:0002576)3.70940479
41negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.70598462
42GPI anchor biosynthetic process (GO:0006506)3.69816042
43regulation of MHC class II biosynthetic process (GO:0045346)3.67739651
44regulation of homotypic cell-cell adhesion (GO:0034110)3.66095121
45megakaryocyte development (GO:0035855)3.66025449
467-methylguanosine mRNA capping (GO:0006370)3.63479600
47homotypic cell-cell adhesion (GO:0034109)3.62353667
48platelet activation (GO:0030168)3.59625835
49regulation of mast cell degranulation (GO:0043304)3.58711360
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.58309675
51purinergic receptor signaling pathway (GO:0035587)3.55769358
527-methylguanosine RNA capping (GO:0009452)3.54595692
53RNA capping (GO:0036260)3.54595692
54G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.54109111
55positive regulation of granulocyte differentiation (GO:0030854)3.53206192
56preassembly of GPI anchor in ER membrane (GO:0016254)3.48044959
57platelet formation (GO:0030220)3.46664400
58leukocyte degranulation (GO:0043299)3.45652703
59regulation of mast cell activation (GO:0033003)3.43151334
60positive regulation of mast cell activation involved in immune response (GO:0033008)3.42550447
61positive regulation of mast cell degranulation (GO:0043306)3.42550447
62positive regulation of receptor recycling (GO:0001921)3.41823735
63regulation of mast cell activation involved in immune response (GO:0033006)3.38874888
64positive regulation of systemic arterial blood pressure (GO:0003084)3.38181030
65GPI anchor metabolic process (GO:0006505)3.32330284
66fusion of sperm to egg plasma membrane (GO:0007342)3.29867305
67regulation of macrophage derived foam cell differentiation (GO:0010743)3.28716794
68positive regulation of Rho protein signal transduction (GO:0035025)3.27720628
69peptidyl-histidine modification (GO:0018202)3.26711479
70termination of RNA polymerase I transcription (GO:0006363)3.23662259
71transcription from RNA polymerase I promoter (GO:0006360)3.22246668
72nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20848190
73negative regulation of response to food (GO:0032096)3.19666454
74negative regulation of appetite (GO:0032099)3.19666454
75protein neddylation (GO:0045116)3.19662524
76maturation of 5.8S rRNA (GO:0000460)3.15304610
77mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.15187212
78negative regulation of erythrocyte differentiation (GO:0045647)3.14242153
79exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11304105
80maturation of SSU-rRNA (GO:0030490)3.10676904
81DNA deamination (GO:0045006)3.08900323
82transcription elongation from RNA polymerase I promoter (GO:0006362)3.08883087
83viral transcription (GO:0019083)3.08592528
84mannosylation (GO:0097502)3.08582686
85negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.06284920
86regulation of endothelial cell differentiation (GO:0045601)3.06043277
87negative regulation of neural precursor cell proliferation (GO:2000178)3.05641610
88regulation of lipoprotein metabolic process (GO:0050746)3.05025268
89myeloid cell activation involved in immune response (GO:0002275)3.04991420
90DNA ligation (GO:0006266)3.04757557
91keratinocyte development (GO:0003334)3.04008070
92regulation of cholesterol efflux (GO:0010874)3.03316273
93deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.03034302
94positive regulation of blood coagulation (GO:0030194)3.02866992
95positive regulation of hemostasis (GO:1900048)3.02866992
96detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.00901273
97termination of signal transduction (GO:0023021)2.99858967
98regulation of nuclear cell cycle DNA replication (GO:0033262)2.99827194
99regulation of Golgi to plasma membrane protein transport (GO:0042996)2.99650371
100regulation of norepinephrine secretion (GO:0014061)2.99484835
101beta-amyloid metabolic process (GO:0050435)2.97958214
102phagocytosis, engulfment (GO:0006911)2.96497222
103protein K6-linked ubiquitination (GO:0085020)2.95932857
104fatty acid elongation (GO:0030497)2.95197088
105isoprenoid biosynthetic process (GO:0008299)2.95080020
106termination of G-protein coupled receptor signaling pathway (GO:0038032)2.94633019
107translational termination (GO:0006415)2.94245275
108positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.93007172
109pyrimidine nucleoside catabolic process (GO:0046135)2.91372352
110extracellular fibril organization (GO:0043206)2.89684192
111Arp2/3 complex-mediated actin nucleation (GO:0034314)2.89372089
112superoxide anion generation (GO:0042554)2.89263627
113negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.88798388
114deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.88498120
115histone H2B ubiquitination (GO:0033523)2.88136238
116autophagic vacuole fusion (GO:0000046)2.88118658
117presynaptic membrane assembly (GO:0097105)2.87214466
118pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.86136030
119regulation of myeloid leukocyte mediated immunity (GO:0002886)2.86089154
120mitochondrial calcium ion transport (GO:0006851)2.84286439
121cytochrome complex assembly (GO:0017004)2.84042852
122negative regulation of T-helper cell differentiation (GO:0045623)2.83613616
123negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.83613616
124microtubule polymerization or depolymerization (GO:0031109)2.83132416
125negative regulation of calcium ion transport into cytosol (GO:0010523)2.83037259
126cellular biogenic amine biosynthetic process (GO:0042401)2.82039053
127transcription initiation from RNA polymerase I promoter (GO:0006361)2.81298532
128tRNA methylation (GO:0030488)2.79729445
129negative regulation of heart contraction (GO:0045822)2.79681629
130DNA damage response, detection of DNA damage (GO:0042769)2.78717329
131regulation of leukocyte degranulation (GO:0043300)2.78634543
132positive regulation of immunoglobulin mediated immune response (GO:0002891)2.78061343
133positive regulation of B cell mediated immunity (GO:0002714)2.78061343
134negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.77175134
135negative regulation of cell killing (GO:0031342)2.77175134
136negative regulation of protein localization to cell surface (GO:2000009)2.75805140
137cyclooxygenase pathway (GO:0019371)2.75293881
138transcription-coupled nucleotide-excision repair (GO:0006283)2.74832978
139presynaptic membrane organization (GO:0097090)2.73428625
140high-density lipoprotein particle remodeling (GO:0034375)2.72838221
141rRNA modification (GO:0000154)2.72774375
142positive regulation of coagulation (GO:0050820)2.72609642
143microglial cell activation (GO:0001774)2.72220023
144telomere maintenance via semi-conservative replication (GO:0032201)2.72060282
145peptide catabolic process (GO:0043171)2.71985794
146microtubule depolymerization (GO:0007019)2.71828944
147phospholipid homeostasis (GO:0055091)2.71582092
148centriole assembly (GO:0098534)2.71424902
149respiratory chain complex IV assembly (GO:0008535)2.71252529
150regulation of mitochondrial translation (GO:0070129)2.70485347
151cotranslational protein targeting to membrane (GO:0006613)2.69638141
152negative regulation of chemokine production (GO:0032682)2.68933715
153membrane invagination (GO:0010324)2.68810416
154negative regulation of stress fiber assembly (GO:0051497)2.68605507
155vesicle targeting (GO:0006903)2.68098226
156protein targeting to mitochondrion (GO:0006626)2.67855954
157regulation of receptor recycling (GO:0001919)2.67606777
158centriole replication (GO:0007099)2.66269012
159SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.65846517
160protein targeting to ER (GO:0045047)2.62853035
161protein localization to endoplasmic reticulum (GO:0070972)2.62753589
162ribonucleoprotein complex biogenesis (GO:0022613)2.61986682
163V(D)J recombination (GO:0033151)2.60842567
164metallo-sulfur cluster assembly (GO:0031163)2.59758001
165iron-sulfur cluster assembly (GO:0016226)2.59758001
166deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.58697813
167protein complex biogenesis (GO:0070271)2.58663371
168cellular component biogenesis (GO:0044085)2.58635589
169energy homeostasis (GO:0097009)2.56660676
170negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.55526992
171CENP-A containing nucleosome assembly (GO:0034080)2.54551677
172C-terminal protein lipidation (GO:0006501)2.53930362
173regulation of development, heterochronic (GO:0040034)2.53122704
174regulation of timing of cell differentiation (GO:0048505)2.51922100
175DNA replication checkpoint (GO:0000076)2.51612881
176oligodendrocyte differentiation (GO:0048709)2.51298701
177positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.50551944
178pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.49305559
179DNA integration (GO:0015074)2.49132028
180establishment of protein localization to endoplasmic reticulum (GO:0072599)2.48356231
181telomere maintenance via recombination (GO:0000722)2.47592774
182establishment of protein localization to mitochondrion (GO:0072655)2.46622454
183positive regulation of viral transcription (GO:0050434)2.45315492
184negative regulation of myoblast differentiation (GO:0045662)2.44705121
185establishment of integrated proviral latency (GO:0075713)2.42667547
186cellular protein complex disassembly (GO:0043624)2.41740568
187spliceosomal complex assembly (GO:0000245)2.40054830
188translation (GO:0006412)2.39879304
189rRNA processing (GO:0006364)2.39054285
190negative regulation of transcription by competitive promoter binding (GO:0010944)2.38399589
191chromatin remodeling at centromere (GO:0031055)2.38140789
192negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.38063704
193DNA-templated transcription, elongation (GO:0006354)2.37495864
194dendritic cell chemotaxis (GO:0002407)2.37169188
195GMP metabolic process (GO:0046037)2.36805372
196DNA-templated transcription, termination (GO:0006353)2.36800408
197positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.35702738
198viral mRNA export from host cell nucleus (GO:0046784)2.35606834

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.23868159
2* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.44634450
3SCL_19346495_ChIP-Seq_HPC-7_Human4.29506973
4LYL1_20887958_ChIP-Seq_HPC-7_Mouse4.24671259
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.02289391
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.98114204
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.87347476
8RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.76050361
9E2F7_22180533_ChIP-Seq_HELA_Human3.53547550
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.49408805
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.19250306
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.15523194
13EST1_17652178_ChIP-ChIP_JURKAT_Human3.12884788
14LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.98645426
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.96708952
16GATA1_19941826_ChIP-Seq_K562_Human2.96643141
17* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.94117016
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.85206454
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83778773
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.74799388
21SPI1_23127762_ChIP-Seq_K562_Human2.74733142
22GATA1_19941827_ChIP-Seq_MEL_Mouse2.74249014
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.73296849
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.72862189
25* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.70687226
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.70225774
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64745077
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.54415036
29GATA2_19941826_ChIP-Seq_K562_Human2.50769937
30TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.50334850
31RUNX1_22412390_ChIP-Seq_EML_Mouse2.40764904
32GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.39346944
33IRF8_27001747_Chip-Seq_BMDM_Mouse2.37812402
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.37349417
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.36421116
36GATA1_22383799_ChIP-Seq_G1ME_Mouse2.36084163
37ETS1_20019798_ChIP-Seq_JURKAT_Human2.36070027
38SRY_22984422_ChIP-ChIP_TESTIS_Rat2.35996890
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30930664
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26800905
41IKZF1_21737484_ChIP-ChIP_HCT116_Human2.24757984
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.21301524
43PCGF2_27294783_Chip-Seq_ESCs_Mouse2.20099486
44GATA2_21666600_ChIP-Seq_HMVEC_Human2.17341399
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.15696817
46FLI1_27457419_Chip-Seq_LIVER_Mouse2.14396538
47RUNX_20019798_ChIP-Seq_JUKART_Human2.11779013
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03429524
49CREB1_15753290_ChIP-ChIP_HEK293T_Human2.01500231
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.94172459
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.93473678
52MYC_18555785_ChIP-Seq_MESCs_Mouse1.90460649
53IRF1_19129219_ChIP-ChIP_H3396_Human1.87900895
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77772236
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.77138876
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.75070456
57ELK4_26923725_Chip-Seq_MESODERM_Mouse1.71287642
58VDR_23849224_ChIP-Seq_CD4+_Human1.70545333
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66618044
60UTX_26944678_Chip-Seq_JUKART_Human1.66609859
61VDR_22108803_ChIP-Seq_LS180_Human1.65162816
62ELK1_19687146_ChIP-ChIP_HELA_Human1.64769143
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63570904
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62461775
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62341251
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.62047269
67GBX2_23144817_ChIP-Seq_PC3_Human1.61696617
68IRF8_22096565_ChIP-ChIP_GC-B_Human1.61612072
69GATA1_22025678_ChIP-Seq_K562_Human1.61179448
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61073395
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60799008
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.59338978
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58904411
74FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58506661
75SPI1_23547873_ChIP-Seq_NB4_Human1.58290666
76* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57389543
77FUS_26573619_Chip-Seq_HEK293_Human1.55295470
78TAF15_26573619_Chip-Seq_HEK293_Human1.54231315
79GATA1_19941827_ChIP-Seq_MEL86_Mouse1.52168067
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51980975
81MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50910184
82VDR_24763502_ChIP-Seq_THP-1_Human1.49160833
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48842334
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47836219
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46822305
86STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46004674
87EZH2_22144423_ChIP-Seq_EOC_Human1.45891587
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45832848
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45286628
90MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44638519
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44425294
92* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.44102853
93CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41758343
94PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40477475
95FOXP3_21729870_ChIP-Seq_TREG_Human1.39832510
96SUZ12_18555785_Chip-Seq_ESCs_Mouse1.36861426
97MYB_26560356_Chip-Seq_TH2_Human1.36738897
98NCOR1_26117541_ChIP-Seq_K562_Human1.32221179
99HTT_18923047_ChIP-ChIP_STHdh_Human1.31805656
100FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30922183
101GATA3_27048872_Chip-Seq_THYMUS_Human1.30866817
102STAT3_18555785_Chip-Seq_ESCs_Mouse1.30420627
103YY1_21170310_ChIP-Seq_MESCs_Mouse1.29921956
104SPI1_20517297_ChIP-Seq_HL60_Human1.29512238
105P300_18555785_Chip-Seq_ESCs_Mouse1.29204233
106FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26141777
107POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26031392
108NMYC_18555785_Chip-Seq_ESCs_Mouse1.24706252
109EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24609528
110RUNX1_27457419_Chip-Seq_LIVER_Mouse1.23813740
111ER_23166858_ChIP-Seq_MCF-7_Human1.23232802
112TCF7_22412390_ChIP-Seq_EML_Mouse1.22484230
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21667930
114KAP1_22055183_ChIP-Seq_ESCs_Mouse1.20855302
115KLF4_18555785_Chip-Seq_ESCs_Mouse1.20766507
116MAF_26560356_Chip-Seq_TH1_Human1.18304113
117NANOG_18555785_Chip-Seq_ESCs_Mouse1.17844919
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.17757708
119SMAD1_18555785_Chip-Seq_ESCs_Mouse1.17259347
120EZH2_27294783_Chip-Seq_NPCs_Mouse1.16688725
121KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.16213155
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14504694
123CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14072275
124ZFX_18555785_Chip-Seq_ESCs_Mouse1.14015567
125YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13700797
126ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13507726
127POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12244203
128RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11826761
129P53_22387025_ChIP-Seq_ESCs_Mouse1.11624966
130ETS1_22383799_ChIP-Seq_G1ME_Mouse1.11417887
131PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.11393698
132SOX2_18555785_Chip-Seq_ESCs_Mouse1.10838935
133FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10313384
134OCT4_18555785_Chip-Seq_ESCs_Mouse1.10076162
135HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09251908
136CMYC_18555785_Chip-Seq_ESCs_Mouse1.08971985
137EWS_26573619_Chip-Seq_HEK293_Human1.08396180
138TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08338328
139CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07497097
140STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06818839
141MYB_26560356_Chip-Seq_TH1_Human1.06555684
142KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06279318
143KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06279318
144KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06279318
145TTF2_22483619_ChIP-Seq_HELA_Human1.05368325
146CBX2_27304074_Chip-Seq_ESCs_Mouse1.05128407
147TP63_19390658_ChIP-ChIP_HaCaT_Human1.04987730
148NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04870487
149CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04746745
150LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03804966
151* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03725017
152XRN2_22483619_ChIP-Seq_HELA_Human1.03080759
153HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02779248
154E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02418410
155MYC_18940864_ChIP-ChIP_HL60_Human1.02167775
156NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01291901
157MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00728899
158PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00441654
159PU_27001747_Chip-Seq_BMDM_Mouse0.99470407
160PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99286031
161GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99256583
162SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98977861
163RNF2_27304074_Chip-Seq_NSC_Mouse0.98820223
164SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98620520
165PU1_27457419_Chip-Seq_LIVER_Mouse0.98309513
166GATA3_26560356_Chip-Seq_TH2_Human0.97459794
167ESRRB_18555785_Chip-Seq_ESCs_Mouse0.96156007
168MYC_22102868_ChIP-Seq_BL_Human0.95696422
169STAT1_20625510_ChIP-Seq_HELA_Human0.94480468
170CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94460877
171CTCF_18555785_Chip-Seq_ESCs_Mouse0.94317007
172RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92822153
173TAL1_26923725_Chip-Seq_HPCs_Mouse0.91545835
174DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91284242
175EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90876629
176TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90101495
177VDR_24787735_ChIP-Seq_THP-1_Human0.88091462
178KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87275747
179ELK3_25401928_ChIP-Seq_HUVEC_Human0.87150686
180SOX2_16153702_ChIP-ChIP_HESCs_Human0.86855718
181CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86718266
182SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86406395
183DCP1A_22483619_ChIP-Seq_HELA_Human0.84437483
184KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83795734
185SALL4_22934838_ChIP-ChIP_CD34+_Human0.82478494
186CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82321231
187FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80693759
188BCL6_27268052_Chip-Seq_Bcells_Human0.79280223
189CTCF_21964334_ChIP-Seq_BJAB-B_Human0.77887919
190CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77771982
191RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77334378
192STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.77166799
193EGR1_23403033_ChIP-Seq_LIVER_Mouse0.76582944
194THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.75770910
195BCOR_27268052_Chip-Seq_Bcells_Human0.75116475
196NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72885675
197NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72885675

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology8.88619040
2MP0008004_abnormal_stomach_pH4.79230206
3MP0005409_darkened_coat_color4.09721212
4MP0003136_yellow_coat_color4.00485918
5MP0004381_abnormal_hair_follicle3.63866578
6MP0005171_absent_coat_pigmentation3.42346059
7MP0000465_gastrointestinal_hemorrhage3.38506233
8MP0003303_peritoneal_inflammation3.24174526
9MP0001188_hyperpigmentation3.23958945
10MP0004510_myositis2.79271498
11MP0006292_abnormal_olfactory_placode2.73171189
12MP0009379_abnormal_foot_pigmentation2.72247293
13MP0000015_abnormal_ear_pigmentation2.41057190
14MP0005075_abnormal_melanosome_morpholog2.38354694
15MP0001529_abnormal_vocalization2.33768135
16MP0005058_abnormal_lysosome_morphology2.31846587
17MP0005408_hypopigmentation2.27319011
18MP0003436_decreased_susceptibility_to2.26284546
19MP0000343_altered_response_to2.20514575
20MP0008057_abnormal_DNA_replication2.19639677
21MP0005083_abnormal_biliary_tract2.19058410
22MP0000566_synostosis2.17306625
23MP0001986_abnormal_taste_sensitivity2.11783492
24MP0008058_abnormal_DNA_repair2.03369298
25MP0002132_abnormal_respiratory_system1.98322882
26MP0003880_abnormal_central_pattern1.92449659
27MP0010155_abnormal_intestine_physiology1.91816966
28MP0003300_gastrointestinal_ulcer1.90005090
29MP0003566_abnormal_cell_adhesion1.88976205
30MP0003718_maternal_effect1.83688344
31MP0000920_abnormal_myelination1.81691833
32MP0000372_irregular_coat_pigmentation1.74299188
33MP0003941_abnormal_skin_development1.72146634
34* MP0002398_abnormal_bone_marrow1.69774784
35MP0004947_skin_inflammation1.69240378
36MP0003693_abnormal_embryo_hatching1.69025844
37MP0001800_abnormal_humoral_immune1.68273320
38MP0002723_abnormal_immune_serum1.68179502
39MP0001905_abnormal_dopamine_level1.67224696
40MP0010094_abnormal_chromosome_stability1.66634473
41MP0005397_hematopoietic_system_phenotyp1.66133922
42MP0001545_abnormal_hematopoietic_system1.66133922
43MP0001851_eye_inflammation1.65815666
44MP0009697_abnormal_copulation1.62029685
45MP0002419_abnormal_innate_immunity1.61002654
46MP0003950_abnormal_plasma_membrane1.60870504
47MP0003828_pulmonary_edema1.60038403
48MP0002095_abnormal_skin_pigmentation1.59696871
49MP0005174_abnormal_tail_pigmentation1.59185912
50MP0004742_abnormal_vestibular_system1.58448080
51MP0000230_abnormal_systemic_arterial1.56860988
52MP0002452_abnormal_antigen_presenting1.56071121
53MP0001533_abnormal_skeleton_physiology1.55889602
54MP0003111_abnormal_nucleus_morphology1.53207705
55MP0005167_abnormal_blood-brain_barrier1.52827781
56MP0005387_immune_system_phenotype1.52705585
57MP0001790_abnormal_immune_system1.52705585
58MP0008789_abnormal_olfactory_epithelium1.50703474
59MP0005025_abnormal_response_to1.50526108
60MP0002420_abnormal_adaptive_immunity1.49774956
61MP0001819_abnormal_immune_cell1.47494009
62MP0000685_abnormal_immune_system1.47238267
63MP0002638_abnormal_pupillary_reflex1.45838504
64MP0002938_white_spotting1.45564005
65MP0003638_abnormal_response/metabolism_1.45192458
66MP0005645_abnormal_hypothalamus_physiol1.44520902
67MP0009764_decreased_sensitivity_to1.42773866
68MP0003879_abnormal_hair_cell1.42231691
69MP0002277_abnormal_respiratory_mucosa1.40760762
70MP0001663_abnormal_digestive_system1.39101143
71MP0000858_altered_metastatic_potential1.37901070
72MP0005646_abnormal_pituitary_gland1.34734143
73MP0003786_premature_aging1.33698084
74MP0008932_abnormal_embryonic_tissue1.33369948
75MP0005084_abnormal_gallbladder_morpholo1.31202598
76MP0000689_abnormal_spleen_morphology1.30863467
77MP0001485_abnormal_pinna_reflex1.29150177
78MP0004084_abnormal_cardiac_muscle1.28073937
79MP0003866_abnormal_defecation1.27712147
80MP0004130_abnormal_muscle_cell1.26597480
81MP0002876_abnormal_thyroid_physiology1.26551915
82MP0001845_abnormal_inflammatory_respons1.25987825
83* MP0002429_abnormal_blood_cell1.24752806
84MP0008260_abnormal_autophagy1.24276645
85MP0001984_abnormal_olfaction1.23802085
86MP0001346_abnormal_lacrimal_gland1.23784976
87MP0009785_altered_susceptibility_to1.22646610
88MP0008007_abnormal_cellular_replicative1.22610136
89MP0000249_abnormal_blood_vessel1.21872557
90MP0009763_increased_sensitivity_to1.20913547
91* MP0000716_abnormal_immune_system1.20782678
92MP0004147_increased_porphyrin_level1.20585161
93MP0003763_abnormal_thymus_physiology1.20117722
94MP0005423_abnormal_somatic_nervous1.19185376
95MP0009278_abnormal_bone_marrow1.17340858
96MP0001486_abnormal_startle_reflex1.17278568
97* MP0002722_abnormal_immune_system1.17108537
98MP0008877_abnormal_DNA_methylation1.15044296
99MP0005551_abnormal_eye_electrophysiolog1.14033606
100MP0002272_abnormal_nervous_system1.13999920
101MP0003077_abnormal_cell_cycle1.13519212
102MP0003724_increased_susceptibility_to1.13431325
103MP0001879_abnormal_lymphatic_vessel1.13255423
104MP0001919_abnormal_reproductive_system1.13167486
105MP0002998_abnormal_bone_remodeling1.13001311
106MP0001186_pigmentation_phenotype1.12804340
107MP0002102_abnormal_ear_morphology1.11365052
108MP0005671_abnormal_response_to1.09359465
109MP0002751_abnormal_autonomic_nervous1.09180999
110MP0002148_abnormal_hypersensitivity_rea1.08884972
111MP0000762_abnormal_tongue_morphology1.08427705
112MP0008872_abnormal_physiological_respon1.07983308
113MP0003075_altered_response_to1.07085316
114MP0005394_taste/olfaction_phenotype1.04971754
115MP0005499_abnormal_olfactory_system1.04971754
116MP0004142_abnormal_muscle_tone1.04822518
117MP0004036_abnormal_muscle_relaxation1.04058407
118MP0005389_reproductive_system_phenotype1.04028329
119MP0002405_respiratory_system_inflammati1.03386695
120MP0008874_decreased_physiological_sensi1.02153023
121MP0000383_abnormal_hair_follicle1.01826701
122MP0003656_abnormal_erythrocyte_physiolo1.01426566
123MP0000490_abnormal_crypts_of0.98795168
124MP0002735_abnormal_chemical_nociception0.97575099
125MP0001963_abnormal_hearing_physiology0.97158662
126MP0004145_abnormal_muscle_electrophysio0.96570318
127MP0009765_abnormal_xenobiotic_induced0.94885101
128MP0002736_abnormal_nociception_after0.94014226
129MP0000613_abnormal_salivary_gland0.92865051
130MP0003938_abnormal_ear_development0.92572439
131MP0008775_abnormal_heart_ventricle0.92081670
132* MP0000703_abnormal_thymus_morphology0.90304846
133MP0009333_abnormal_splenocyte_physiolog0.90075461
134MP0006082_CNS_inflammation0.88667742
135MP0002733_abnormal_thermal_nociception0.87747247
136MP0000026_abnormal_inner_ear0.87291697
137MP0005310_abnormal_salivary_gland0.84867148
138MP0009642_abnormal_blood_homeostasis0.84573970
139MP0002163_abnormal_gland_morphology0.84521979
140MP0005381_digestive/alimentary_phenotyp0.83703186
141MP0010329_abnormal_lipoprotein_level0.82539557
142MP0002210_abnormal_sex_determination0.82015915
143MP0003453_abnormal_keratinocyte_physiol0.79691685
144MP0002752_abnormal_somatic_nervous0.79092700
145MP0003172_abnormal_lysosome_physiology0.78097287
146MP0005165_increased_susceptibility_to0.76445218
147MP0006054_spinal_hemorrhage0.76037790
148MP0001968_abnormal_touch/_nociception0.75909783
149MP0002075_abnormal_coat/hair_pigmentati0.75568584
150MP0005410_abnormal_fertilization0.75507800
151MP0002098_abnormal_vibrissa_morphology0.74758753
152MP0003315_abnormal_perineum_morphology0.74150568
153MP0002160_abnormal_reproductive_system0.73621412
154MP0001661_extended_life_span0.73486946
155MP0008995_early_reproductive_senescence0.72368003
156MP0003195_calcinosis0.71990485
157MP0001542_abnormal_bone_strength0.70953186
158MP0002877_abnormal_melanocyte_morpholog0.70407602
159MP0005253_abnormal_eye_physiology0.70146486
160MP0005023_abnormal_wound_healing0.68646287
161MP0010386_abnormal_urinary_bladder0.67421691
162MP0001835_abnormal_antigen_presentation0.67006556
163MP0004883_abnormal_blood_vessel0.66813984
164MP0003795_abnormal_bone_structure0.66568282
165MP0005666_abnormal_adipose_tissue0.65605594
166MP0001765_abnormal_ion_homeostasis0.65285104
167MP0005451_abnormal_body_composition0.65187511
168MP0005365_abnormal_bile_salt0.64703322
169MP0004957_abnormal_blastocyst_morpholog0.64511938
170MP0002233_abnormal_nose_morphology0.64418896
171MP0000778_abnormal_nervous_system0.63559899
172MP0001293_anophthalmia0.63409680
173MP0003448_altered_tumor_morphology0.62533761
174MP0003183_abnormal_peptide_metabolism0.62354792
175MP0001970_abnormal_pain_threshold0.62030013
176MP0004808_abnormal_hematopoietic_stem0.61835531
177MP0005535_abnormal_body_temperature0.61221145
178MP0001502_abnormal_circadian_rhythm0.60891517
179MP0002118_abnormal_lipid_homeostasis0.60549125
180MP0004782_abnormal_surfactant_physiolog0.60151884
181MP0005000_abnormal_immune_tolerance0.59989159
182MP0001286_abnormal_eye_development0.59985166
183MP0000647_abnormal_sebaceous_gland0.59719340
184MP0003937_abnormal_limbs/digits/tail_de0.59404000

Predicted human phenotypes

RankGene SetZ-score
1Abnormal platelet volume (HP:0011876)9.96188157
2Petechiae (HP:0000967)9.51460499
3Purpura (HP:0000979)9.30631560
4Epistaxis (HP:0000421)7.58082428
5Gingival bleeding (HP:0000225)6.22648460
6Hyperlipoproteinemia (HP:0010980)5.66157544
7Abnormal platelet function (HP:0011869)5.28567874
8Impaired platelet aggregation (HP:0003540)5.28567874
9Spontaneous hematomas (HP:0007420)4.79327077
10Parakeratosis (HP:0001036)4.47883470
11Duplicated collecting system (HP:0000081)4.30710366
12Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.08224912
13Abnormality of the renal collecting system (HP:0004742)3.85403235
14Conjunctival telangiectasia (HP:0000524)3.79586378
15Acanthocytosis (HP:0001927)3.58859672
16Poikilocytosis (HP:0004447)3.52108675
17Abnormality of macrophages (HP:0004311)3.51221199
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.49859724
19Abnormality of the vasculature of the conjunctiva (HP:0008054)3.42664451
203-Methylglutaconic aciduria (HP:0003535)3.36312393
21Dyschromatopsia (HP:0007641)3.34838977
22Chromosomal breakage induced by crosslinking agents (HP:0003221)3.32011876
23Abnormality of lateral ventricle (HP:0030047)3.26504232
24Bruising susceptibility (HP:0000978)3.17650658
25Stomatitis (HP:0010280)3.14349688
26Chromsome breakage (HP:0040012)3.13388052
27Renal Fanconi syndrome (HP:0001994)3.13235661
28Abnormality of the common coagulation pathway (HP:0010990)3.13211374
29Increased density of long bones (HP:0006392)3.07318328
30Abnormal pupillary function (HP:0007686)2.99364978
31Hepatosplenomegaly (HP:0001433)2.97024996
32Cerebral hypomyelination (HP:0006808)2.93924300
33Abnormality of the heme biosynthetic pathway (HP:0010472)2.93715156
34Eczematoid dermatitis (HP:0000976)2.90103473
35Increased IgM level (HP:0003496)2.87082574
36Birth length less than 3rd percentile (HP:0003561)2.83564895
37Congenital ichthyosiform erythroderma (HP:0007431)2.81411123
38Reticulocytopenia (HP:0001896)2.80221228
39Paralysis (HP:0003470)2.74057673
40Breast hypoplasia (HP:0003187)2.71693659
41Abnormality of cells of the erythroid lineage (HP:0012130)2.71195774
42Obstructive lung disease (HP:0006536)2.70175016
43Chronic obstructive pulmonary disease (HP:0006510)2.70175016
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.65543863
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.65543863
46Acute necrotizing encephalopathy (HP:0006965)2.64280313
47Abnormal number of erythroid precursors (HP:0012131)2.61461581
48White forelock (HP:0002211)2.56361350
49Increased hepatocellular lipid droplets (HP:0006565)2.56144689
50Septo-optic dysplasia (HP:0100842)2.54770984
51Aplasia/Hypoplasia of the fovea (HP:0008060)2.53920239
52Hypoplasia of the fovea (HP:0007750)2.53920239
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.53288785
54Encephalitis (HP:0002383)2.52043633
55Patchy hypopigmentation of hair (HP:0011365)2.51846761
56Mitochondrial inheritance (HP:0001427)2.42731353
57Abnormality of secondary sexual hair (HP:0009888)2.41391953
58Abnormality of the axillary hair (HP:0100134)2.41391953
59Type I transferrin isoform profile (HP:0003642)2.33332858
60Erythroderma (HP:0001019)2.33217557
61Xanthomatosis (HP:0000991)2.32670429
62Exertional dyspnea (HP:0002875)2.32450480
63Abnormality of iron homeostasis (HP:0011031)2.31275251
64Conical tooth (HP:0000698)2.30943842
65Joint swelling (HP:0001386)2.30467867
66Recurrent abscess formation (HP:0002722)2.29145409
67Abnormality of the septum pellucidum (HP:0007375)2.26727799
68Episodic fever (HP:0001954)2.23977409
69Abnormality of renal resorption (HP:0011038)2.23318829
70Medial flaring of the eyebrow (HP:0010747)2.22520396
71Granulocytopenia (HP:0001913)2.20597775
72Eosinophilia (HP:0001880)2.19023281
73Aplasia cutis congenita (HP:0001057)2.18786463
74Stomach cancer (HP:0012126)2.17444957
75Recurrent bacterial skin infections (HP:0005406)2.16123502
76Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.15618257
77Increased serum ferritin (HP:0003281)2.15130113
78Aplasia/Hypoplasia involving the musculature (HP:0001460)2.14862397
79Absent septum pellucidum (HP:0001331)2.14466829
80Joint hemorrhage (HP:0005261)2.12223108
81Hyperthyroidism (HP:0000836)2.12130062
82Aplasia/hypoplasia of the uterus (HP:0008684)2.10500838
83Optic nerve hypoplasia (HP:0000609)2.09570666
84Macrocytic anemia (HP:0001972)2.08403205
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.07614661
86True hermaphroditism (HP:0010459)2.06184393
87Congenital primary aphakia (HP:0007707)2.05917281
88Gait imbalance (HP:0002141)2.05033746
89Prostate neoplasm (HP:0100787)2.03616806
90Ventricular fibrillation (HP:0001663)2.02950525
91Abnormal mitochondria in muscle tissue (HP:0008316)2.02625768
92Increased CSF lactate (HP:0002490)2.02459754
93Progressive macrocephaly (HP:0004481)2.00860984
94Prolonged bleeding time (HP:0003010)11.5539960
95Increased mean platelet volume (HP:0011877)10.3303542
96Menorrhagia (HP:0000132)10.3260266
97Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.99597736
98Ureteral duplication (HP:0000073)1.99382398
99Nephrogenic diabetes insipidus (HP:0009806)1.99076845
100Increased serum lactate (HP:0002151)1.98986710
101Dysostosis multiplex (HP:0000943)1.98922563
102Autoimmune hemolytic anemia (HP:0001890)1.98771782
103Lipid accumulation in hepatocytes (HP:0006561)1.98724875
104Abnormal auditory evoked potentials (HP:0006958)1.98598081
105Arterial thrombosis (HP:0004420)1.97758503
106Polycythemia (HP:0001901)1.96943961
107Acute encephalopathy (HP:0006846)1.95916296
108Duplication of thumb phalanx (HP:0009942)1.95104450
109Abnormality of transition element cation homeostasis (HP:0011030)1.94950340
110Congenital sensorineural hearing impairment (HP:0008527)1.94697686
111Abnormality of the fovea (HP:0000493)1.94590925
112Pancreatic fibrosis (HP:0100732)1.94186081
113Upper limb muscle weakness (HP:0003484)1.93965070
114Hepatocellular necrosis (HP:0001404)1.93259697
115Hypophosphatemic rickets (HP:0004912)1.92984933
116Type 2 muscle fiber atrophy (HP:0003554)1.92462980
117Congenital stationary night blindness (HP:0007642)1.91163406
118Pulmonary artery stenosis (HP:0004415)1.90953857
119Optic disc pallor (HP:0000543)1.90218867
120Abnormality of placental membranes (HP:0011409)1.89833147
121Amniotic constriction ring (HP:0009775)1.89833147
122Increased intramyocellular lipid droplets (HP:0012240)1.88278781
123Sensory axonal neuropathy (HP:0003390)1.87293199
124Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87161763
125Nausea (HP:0002018)1.86633957
126Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86318332
127Leukocytosis (HP:0001974)1.85859396
128Pancreatic cysts (HP:0001737)1.85713478
129Decreased central vision (HP:0007663)1.85570869
130Generalized aminoaciduria (HP:0002909)1.85458861
131Dysautonomia (HP:0002459)1.84214299
132Aplasia of the musculature (HP:0100854)1.83848830
133Elevated erythrocyte sedimentation rate (HP:0003565)1.83552926
134Microvesicular hepatic steatosis (HP:0001414)1.83384386
135Abnormality of the preputium (HP:0100587)1.83257365
136Absent/shortened dynein arms (HP:0200106)1.82848626
137Dynein arm defect of respiratory motile cilia (HP:0012255)1.82848626
138Myocardial infarction (HP:0001658)1.82129685
139Progressive external ophthalmoplegia (HP:0000590)1.81890390
140Basal ganglia calcification (HP:0002135)1.81517000
141Abnormality of the ileum (HP:0001549)1.81394394
142Retinal dysplasia (HP:0007973)1.81042934
143Absent radius (HP:0003974)1.80838401
144Male infertility (HP:0003251)1.80830588
145Meckel diverticulum (HP:0002245)1.80096700
146Long foot (HP:0001833)1.78246406
147Tinnitus (HP:0000360)1.76726982
148Atelectasis (HP:0100750)1.76697312
149Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76185470
150Aplasia involving forearm bones (HP:0009822)1.74613387
151Absent forearm bone (HP:0003953)1.74613387
152Panhypogammaglobulinemia (HP:0003139)1.74248833
153Patellar aplasia (HP:0006443)1.73465756
154Leukodystrophy (HP:0002415)1.72904108
155Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72473730
156Absent epiphyses (HP:0010577)1.72473730
157Chest pain (HP:0100749)1.70270028
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.69621460
159Triphalangeal thumb (HP:0001199)1.67614673
160Absent hand (HP:0004050)1.67405153
161Abnormality of the prostate (HP:0008775)1.67012275
162Abnormality of chromosome stability (HP:0003220)1.66928307
163Premature graying of hair (HP:0002216)1.66190969
164Exercise intolerance (HP:0003546)1.65938231
165Vertigo (HP:0002321)1.65342581
166Papillary thyroid carcinoma (HP:0002895)1.62619732
167Inflammation of the large intestine (HP:0002037)1.62406165
168Recurrent fungal infections (HP:0002841)1.60466254
169Diplopia (HP:0000651)1.57768690
170Abnormality of binocular vision (HP:0011514)1.57768690
171Mucosal telangiectasiae (HP:0100579)1.57144285
172Increased IgE level (HP:0003212)1.52264998
173Pulmonary embolism (HP:0002204)1.52121453
174Distal lower limb amyotrophy (HP:0008944)1.52055322
175Increased cerebral lipofuscin (HP:0011813)1.51104636
176Thrombophlebitis (HP:0004418)1.49076149
177Gastrointestinal inflammation (HP:0004386)1.49011446
178Meningitis (HP:0001287)1.48124322
179Cerebral ischemia (HP:0002637)1.47587318
180T lymphocytopenia (HP:0005403)1.46357156
181Hypertriglyceridemia (HP:0002155)1.45464717
182Microcytic anemia (HP:0001935)1.44858765
183Myositis (HP:0100614)1.44803215
184Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.44474142
185Muscle fibrillation (HP:0010546)1.44169224
186Vasculitis (HP:0002633)1.43323358
187Retrobulbar optic neuritis (HP:0100654)1.41954392
188Optic neuritis (HP:0100653)1.41954392
189Hemorrhage of the eye (HP:0011885)1.41044423
190Thyroid-stimulating hormone excess (HP:0002925)1.40733183
191Increased neuronal autofluorescent lipopigment (HP:0002074)1.40173725
192Hypergammaglobulinemia (HP:0010702)1.39478660
193Transitional cell carcinoma of the bladder (HP:0006740)1.38220772
194Autoimmune thrombocytopenia (HP:0001973)1.37674744
195Orchitis (HP:0100796)1.37198045
196Arthralgia (HP:0002829)1.35575065

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.87568513
2BMX3.96406975
3CASK3.12467963
4MYLK2.89456575
5PBK2.88384767
6IRAK32.58314536
7ZAP702.49342859
8PLK42.43885045
9GRK62.43587948
10SYK2.40785741
11PTK2B2.37159988
12STK162.32146461
13ZAK2.31036179
14CDK192.26851332
15SRPK12.26357981
16BMPR1B2.12689088
17FGR2.07219401
18CSF1R2.06599533
19TAOK32.05641045
20MST42.05344085
21GRK52.04628391
22IRAK42.01208196
23BUB11.87650116
24AKT31.87029520
25MKNK21.86927892
26EIF2AK11.86485595
27VRK11.83601290
28PRPF4B1.81895670
29IRAK11.80587288
30PKN11.74311794
31TXK1.73860509
32MAP2K31.73331166
33FES1.73190742
34ILK1.69522046
35HCK1.67448537
36STK391.66587095
37IRAK21.65117864
38EIF2AK31.63458323
39MKNK11.60676709
40TNIK1.57797285
41OXSR11.57368677
42PIK3CG1.51927014
43TNK21.50725351
44NEK61.42175649
45ADRBK21.35906428
46PINK11.35716062
47CSK1.34374479
48BMPR21.34334772
49LYN1.34304085
50TAOK11.33213758
51PIM21.29214660
52YES11.28395485
53MAP4K11.28368753
54TAOK21.28117194
55BCR1.24356544
56WEE11.23669889
57DAPK31.21196214
58MAP3K31.18427643
59MATK1.13528076
60EIF2AK21.13431585
61PAK11.13391294
62NME21.07758339
63TSSK61.07344498
64TRPM71.05758048
65MAPK131.05467927
66MAP3K111.04320150
67MARK31.02124117
68CLK11.00759031
69TLK10.99927792
70ARAF0.99637084
71MARK10.98796715
72MAPKAPK30.97750871
73NLK0.96320757
74STK30.95655086
75SIK30.95589846
76ITK0.94993214
77LMTK20.94991676
78BRAF0.94951110
79STK240.94832498
80ACVR1B0.94480003
81MAPK150.94137877
82CCNB10.91935715
83MAP3K50.89111773
84DYRK20.88916339
85PLK30.88322323
86RPS6KA50.87047669
87BLK0.82121348
88ATR0.77437107
89MAP2K70.77406023
90GRK10.77027395
91BRSK10.76869368
92PDK10.75519890
93EPHB10.74662459
94MAPK120.72430312
95CSNK1G30.72161091
96LCK0.71942763
97CDK30.71284619
98MAPKAPK50.70639626
99RET0.70597155
100ADRBK10.69348906
101TESK20.68461315
102MAPK70.68303357
103CSNK1A1L0.67759250
104DAPK20.65200959
105TTK0.64883643
106MUSK0.64369291
107NUAK10.62402545
108PLK10.61997041
109JAK20.61796217
110AURKA0.61617869
111PDPK10.61503641
112CAMK2B0.59620748
113GRK70.59060855
114SGK4940.58238573
115SGK2230.58238573
116PRKD10.57941446
117BTK0.57677794
118CAMKK20.56899667
119EPHA30.55102037
120JAK30.54807145
121INSRR0.54632149
122MAP3K140.54390920
123FYN0.54212901
124EPHA20.53645979
125PDGFRB0.53401238
126TEC0.53332416
127PNCK0.53286526
128BRSK20.50387944
129MAP3K10.48402514
130PLK20.48150233
131CSNK1G10.47704758
132ERBB20.46818062
133IKBKB0.46754630
134JAK10.46619107
135CDC70.46565504
136EPHB20.46134314
137PRKCE0.45310385
138CHEK20.44523615
139HIPK20.42976072
140CDK70.42239352
141PIM10.42222434
142PRKACG0.41285049
143CAMK2D0.40601917
144STK40.40212652
145AURKB0.39795818
146LIMK10.38426545
147DAPK10.37525029
148ROCK20.37494041
149CSNK2A10.37381372
150PRKCQ0.37099215
151RPS6KB20.36080764
152MAPK110.35573136
153PRKD20.35565540
154RAF10.34909560
155MAP3K120.34595525
156BRD40.34289851
157CHEK10.33898351
158UHMK10.33679600
159ATM0.32613287
160PRKCD0.30401872
161MARK20.29753115
162CDK140.29276128
163DYRK1B0.29177585
164MAP2K10.27605932
165PRKG10.24782223
166PRKCB0.23187220
167PKN20.22784729
168CDC42BPA0.22315708
169TYK20.20056472
170TRIM280.19921339
171SRC0.16798294

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046114.93203476
2Ribosome_Homo sapiens_hsa030103.91763488
3RNA polymerase_Homo sapiens_hsa030203.77137508
4Proteasome_Homo sapiens_hsa030503.15153563
5Oxidative phosphorylation_Homo sapiens_hsa001902.78276958
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.71403428
7DNA replication_Homo sapiens_hsa030302.43406850
8Fanconi anemia pathway_Homo sapiens_hsa034602.32347622
9Mismatch repair_Homo sapiens_hsa034302.25816821
10Pyrimidine metabolism_Homo sapiens_hsa002402.21217195
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20163666
12Protein export_Homo sapiens_hsa030602.14868125
13Steroid biosynthesis_Homo sapiens_hsa001002.14461522
14Parkinsons disease_Homo sapiens_hsa050122.05977397
15Homologous recombination_Homo sapiens_hsa034402.05044134
16Spliceosome_Homo sapiens_hsa030402.04980421
17Chemokine signaling pathway_Homo sapiens_hsa040622.00016015
18Non-homologous end-joining_Homo sapiens_hsa034501.88538607
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.87018849
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.83933904
21Basal transcription factors_Homo sapiens_hsa030221.81685608
22Vitamin B6 metabolism_Homo sapiens_hsa007501.76500978
23ECM-receptor interaction_Homo sapiens_hsa045121.70684886
24B cell receptor signaling pathway_Homo sapiens_hsa046621.67660075
25Huntingtons disease_Homo sapiens_hsa050161.67165422
26Purine metabolism_Homo sapiens_hsa002301.65858603
27Osteoclast differentiation_Homo sapiens_hsa043801.63150836
28Alzheimers disease_Homo sapiens_hsa050101.55128712
29Ether lipid metabolism_Homo sapiens_hsa005651.49617164
30Arachidonic acid metabolism_Homo sapiens_hsa005901.47253215
31Gap junction_Homo sapiens_hsa045401.47005946
32Sphingolipid metabolism_Homo sapiens_hsa006001.46656761
33Fatty acid elongation_Homo sapiens_hsa000621.44982850
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44694322
35Nucleotide excision repair_Homo sapiens_hsa034201.44279623
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.42823097
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40520053
38Staphylococcus aureus infection_Homo sapiens_hsa051501.39664743
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.37229797
40Shigellosis_Homo sapiens_hsa051311.34607854
41Base excision repair_Homo sapiens_hsa034101.34161095
42Vascular smooth muscle contraction_Homo sapiens_hsa042701.32498078
43RNA degradation_Homo sapiens_hsa030181.30530764
44Endocytosis_Homo sapiens_hsa041441.30036712
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26093362
46Phototransduction_Homo sapiens_hsa047441.22964737
47Linoleic acid metabolism_Homo sapiens_hsa005911.22525083
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21428957
49Autoimmune thyroid disease_Homo sapiens_hsa053201.21378487
50Graft-versus-host disease_Homo sapiens_hsa053321.17739703
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.17021476
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16661484
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14035993
54Primary immunodeficiency_Homo sapiens_hsa053401.13888554
55Nitrogen metabolism_Homo sapiens_hsa009101.12153662
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10567434
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09446459
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09260857
59Pancreatic cancer_Homo sapiens_hsa052121.09233699
60Leishmaniasis_Homo sapiens_hsa051401.07074152
61Cell cycle_Homo sapiens_hsa041101.06302587
62RNA transport_Homo sapiens_hsa030131.05263071
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04272177
64Phospholipase D signaling pathway_Homo sapiens_hsa040721.02612668
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01938226
66Non-small cell lung cancer_Homo sapiens_hsa052231.00636956
67Rheumatoid arthritis_Homo sapiens_hsa053230.96741216
68Allograft rejection_Homo sapiens_hsa053300.95340982
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94347671
70Tuberculosis_Homo sapiens_hsa051520.88763901
71Glycerolipid metabolism_Homo sapiens_hsa005610.88641123
72Viral carcinogenesis_Homo sapiens_hsa052030.87889128
73Endometrial cancer_Homo sapiens_hsa052130.85496042
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.85281896
75Pancreatic secretion_Homo sapiens_hsa049720.83784969
76Acute myeloid leukemia_Homo sapiens_hsa052210.83377098
77Hematopoietic cell lineage_Homo sapiens_hsa046400.81099844
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80869840
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78631512
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.74588840
81Rap1 signaling pathway_Homo sapiens_hsa040150.74458820
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74305469
83Serotonergic synapse_Homo sapiens_hsa047260.73371875
84Thyroid cancer_Homo sapiens_hsa052160.73082873
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70779030
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70133659
87Salmonella infection_Homo sapiens_hsa051320.69363035
88Apoptosis_Homo sapiens_hsa042100.69264735
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69003080
90Choline metabolism in cancer_Homo sapiens_hsa052310.67675129
91p53 signaling pathway_Homo sapiens_hsa041150.66974392
92Collecting duct acid secretion_Homo sapiens_hsa049660.66770816
93Lysosome_Homo sapiens_hsa041420.65314813
94Glutathione metabolism_Homo sapiens_hsa004800.65078055
95Olfactory transduction_Homo sapiens_hsa047400.65005954
96Epstein-Barr virus infection_Homo sapiens_hsa051690.63794425
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63299686
98Chronic myeloid leukemia_Homo sapiens_hsa052200.63137393
99Toxoplasmosis_Homo sapiens_hsa051450.62802309
100Sulfur relay system_Homo sapiens_hsa041220.60855956
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60744822
102VEGF signaling pathway_Homo sapiens_hsa043700.60649576
103Focal adhesion_Homo sapiens_hsa045100.60484155
104Folate biosynthesis_Homo sapiens_hsa007900.60470293
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59686496
106Vitamin digestion and absorption_Homo sapiens_hsa049770.59298231
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58981386
108Metabolic pathways_Homo sapiens_hsa011000.58643431
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58236472
110Viral myocarditis_Homo sapiens_hsa054160.57794219
111Glioma_Homo sapiens_hsa052140.57345731
112Small cell lung cancer_Homo sapiens_hsa052220.57305158
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.57213053
114Nicotine addiction_Homo sapiens_hsa050330.56449068
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56403543
116One carbon pool by folate_Homo sapiens_hsa006700.55776940
117Histidine metabolism_Homo sapiens_hsa003400.54584237
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.54008665
119Ras signaling pathway_Homo sapiens_hsa040140.53460446
120Renin-angiotensin system_Homo sapiens_hsa046140.52087789
121Legionellosis_Homo sapiens_hsa051340.51794507
122Sulfur metabolism_Homo sapiens_hsa009200.51579343
123Amoebiasis_Homo sapiens_hsa051460.51550226
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.49963049
125Circadian entrainment_Homo sapiens_hsa047130.47872223
126Arginine and proline metabolism_Homo sapiens_hsa003300.47009898
127Renal cell carcinoma_Homo sapiens_hsa052110.46246973
128Melanoma_Homo sapiens_hsa052180.45291785
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45224841
130Systemic lupus erythematosus_Homo sapiens_hsa053220.45222696
131Asthma_Homo sapiens_hsa053100.45094399
132Type I diabetes mellitus_Homo sapiens_hsa049400.45004123
133Axon guidance_Homo sapiens_hsa043600.44745860
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44368429
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44299086
136Hepatitis B_Homo sapiens_hsa051610.43716178
137Retinol metabolism_Homo sapiens_hsa008300.41905778
138TNF signaling pathway_Homo sapiens_hsa046680.41306206
139Measles_Homo sapiens_hsa051620.40276347
140Steroid hormone biosynthesis_Homo sapiens_hsa001400.40059551
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38382987
142Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37690244
143Cardiac muscle contraction_Homo sapiens_hsa042600.37001957
144Prostate cancer_Homo sapiens_hsa052150.36938944
145Calcium signaling pathway_Homo sapiens_hsa040200.36836754
146Glycosaminoglycan degradation_Homo sapiens_hsa005310.36225762
147Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33657689
148NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33385067
149Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33272335
150African trypanosomiasis_Homo sapiens_hsa051430.30636414
151Mineral absorption_Homo sapiens_hsa049780.29871778
152Alcoholism_Homo sapiens_hsa050340.29532854
153Morphine addiction_Homo sapiens_hsa050320.29055653
154Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28784193
155RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28585797
156Phagosome_Homo sapiens_hsa041450.26154372
157Taste transduction_Homo sapiens_hsa047420.25943469
158T cell receptor signaling pathway_Homo sapiens_hsa046600.25440998
159Malaria_Homo sapiens_hsa051440.25165011
160Other glycan degradation_Homo sapiens_hsa005110.24751267
161Regulation of autophagy_Homo sapiens_hsa041400.23622133
162mRNA surveillance pathway_Homo sapiens_hsa030150.22000388
163Pertussis_Homo sapiens_hsa051330.21680837
164Ovarian steroidogenesis_Homo sapiens_hsa049130.21326118
165Herpes simplex infection_Homo sapiens_hsa051680.20061264
166Long-term depression_Homo sapiens_hsa047300.19704066

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